PE20030527A1 - Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen - Google Patents
Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienenInfo
- Publication number
- PE20030527A1 PE20030527A1 PE2002001030A PE2002001030A PE20030527A1 PE 20030527 A1 PE20030527 A1 PE 20030527A1 PE 2002001030 A PE2002001030 A PE 2002001030A PE 2002001030 A PE2002001030 A PE 2002001030A PE 20030527 A1 PE20030527 A1 PE 20030527A1
- Authority
- PE
- Peru
- Prior art keywords
- dimethylamino
- phenol
- propyl
- ethyl
- methyl
- Prior art date
Links
- KWTWDQCKEHXFFR-UHFFFAOYSA-N 3-[1-(dimethylamino)-2-methylpentan-3-yl]phenol Chemical compound CN(C)CC(C)C(CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-UHFFFAOYSA-N 0.000 title abstract 2
- 239000007935 oral tablet Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 230000003111 delayed effect Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229920001600 hydrophobic polymer Polymers 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
DONDE DICHA FORMULACION SE ENCUENTRA EN UNA MATRIZ CON LIBERACION RETARDADA DE SUSTANCIA ACTIVA, LA CUAL CONTIENE 1% A 80% DE UNO O VARIOS POLIMEROS HIDROFILOS O HIDROFOBOS COMO FORMADORES DE MATRIZ FARMACEUTICAMENTE ACEPTABLES Y QUE PRESENTA IN VITRO UNA VELOCIDAD DE LIBERACION MEDIDA CON APLICACION DEL METODO PADDLE pH. Eur. DE 75 REVOLUCIONES/min EN UN TAMPON A pH 6,8 A 37 °C CON DETECCION ESPECTROMETRICA UV. TENIENDO LOS SIGUIENTES PORCENTAJES DE LIBERACION DE 3-(3-DIMETILAMINO-1-ETIL-2-METIL-PROPIL) FENOL, MEDIDOS EN RELACION AL 100% DEL PESO DE LA SUSTANCIA ACTIVA : a)DE 3% A 35% DESPUES DE 0,5 h; b)5% A 50% DESPUES DE 1 h; c)10% A 75% DESPUES DE 2 h; d)15% A 82% DESPUES DE 3 h; e)39% A 97% DESPUES DE 6 h; f)MAS DE 50% DESPUES DE 12 h; g)MAS DE 70% DESPUES DE 18 h; h)MAS DE 80% DESPUES DE 24 h
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10152469A DE10152469A1 (de) | 2001-10-24 | 2001-10-24 | 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)phenol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung |
| DE2002148309 DE10248309A1 (de) | 2002-10-16 | 2002-10-16 | 3-(3- Dimethylamino-1-ethyl-2-methyl-propyl) phenol enthaltendes Arzeimittel mit verzögerter Wirkstofffreisetzung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030527A1 true PE20030527A1 (es) | 2003-07-26 |
Family
ID=26010444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001030A PE20030527A1 (es) | 2001-10-24 | 2002-10-18 | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US20050058706A1 (es) |
| EP (1) | EP1439829B1 (es) |
| JP (2) | JP4758064B2 (es) |
| KR (1) | KR100958045B1 (es) |
| CN (1) | CN100402021C (es) |
| AR (1) | AR036943A1 (es) |
| AT (1) | ATE303802T1 (es) |
| AU (1) | AU2002349001C1 (es) |
| BR (1) | BRPI0213653B8 (es) |
| CA (1) | CA2464578C (es) |
| CO (1) | CO5570662A2 (es) |
| CY (1) | CY2012022I2 (es) |
| DE (1) | DE50204198D1 (es) |
| DK (1) | DK1439829T3 (es) |
| EC (1) | ECSP045102A (es) |
| ES (1) | ES2248622T3 (es) |
| HK (1) | HK1068539A1 (es) |
| HU (1) | HU230161B1 (es) |
| IL (2) | IL161587A0 (es) |
| MX (1) | MXPA04003742A (es) |
| MY (1) | MY127797A (es) |
| NO (2) | NO331896B1 (es) |
| NZ (1) | NZ532999A (es) |
| PE (1) | PE20030527A1 (es) |
| PL (1) | PL216535B1 (es) |
| PT (1) | PT1439829E (es) |
| SI (1) | SI1439829T1 (es) |
| WO (2) | WO2003035054A1 (es) |
| ZA (1) | ZA200403928B (es) |
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|---|---|---|---|---|
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| PT1685829E (pt) | 2002-11-22 | 2008-05-15 | Gruenenthal Gmbh | Utilização de (1rs,3rs,6rs)-6-dimetilaminometil-1-(3-metoxifenil) ciclo-hexano-1,3-diol para tratamento da dor inflamatória |
| DE102005005446A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE102004020220A1 (de) * | 2004-04-22 | 2005-11-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| US20070048228A1 (en) * | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| US20070183980A1 (en) * | 2003-08-06 | 2007-08-09 | Elisabeth Arkenau-Maric | Dosage form that is safeguarded from abuse |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| DE10361596A1 (de) * | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| ES2291780T3 (es) | 2004-06-28 | 2008-03-01 | Grunenthal Gmbh | Formas cristalinas del clorhidrato de (-)-(1r,2r)-3-(3-dimetilamino-1-etil-2-metilpropil)fenol. |
| PL1786403T3 (pl) * | 2004-07-01 | 2013-10-31 | Gruenenthal Gmbh | Doustna postać dawki zabezpieczona przed nadużywaniem zawierająca (1R, 2R)-3-(3-dimetyloamino-1-etylo0-2-metylo-propylo)fenol |
| DE102004032103A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| ES2356093T3 (es) * | 2006-04-28 | 2011-04-04 | Grünenthal GmbH | Combinación farmacéutica que comprende 3-(3-dimetilamino-1-etil-2-metilpropil)fenol y paracetamol. |
| SI2012763T1 (sl) * | 2006-04-28 | 2011-06-30 | Gruenenthal Gmbh | Farmacevtska kombinacija, ki obsega 3-(3-dimetilamino-1-etil-2-metil- propil)-fenol in NSAID |
| CN101091725A (zh) * | 2006-06-23 | 2007-12-26 | 天津天士力制药股份有限公司 | 一种中药颗粒及其制备方法 |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| DE102007011485A1 (de) * | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| EP1985292A1 (en) * | 2007-04-23 | 2008-10-29 | Grünenthal GmbH | Titration of tapentadol |
| DE102007019417A1 (de) | 2007-04-23 | 2008-11-13 | Grünenthal GmbH | Tapentadol zur Schmerzbehandlung bei Arthrose |
| EP2596784B1 (en) * | 2007-11-23 | 2016-12-21 | Grünenthal GmbH | Tapentadol compositions |
| HUE047275T2 (hu) * | 2007-12-07 | 2020-04-28 | Gruenenthal Gmbh | (1R,2R)-3-(3-dimetil-amino-1-etil-2-metil-propil)-fenol kristályos módosításait tartalmazó gyógyszerek |
| MX2010008138A (es) | 2008-01-25 | 2010-08-10 | Gruenenthal Gmbh | Forma de dosis farmaceutica. |
| PL2273983T3 (pl) | 2008-05-09 | 2017-01-31 | Grünenthal GmbH | Sposób wytwarzania pośredniego preparatu proszkowego i końcowej stałej postaci dawkowania z zastosowaniem etapu zestalania rozpyłowego |
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| NZ596667A (en) | 2009-07-22 | 2013-09-27 | Gruenenthal Chemie | Hot-melt extruded controlled release dosage form |
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| US9884022B2 (en) | 2010-04-07 | 2018-02-06 | Lupin Limited | Controlled release pharmaceutical compositions of tapentadol |
| US20130116333A1 (en) * | 2010-05-05 | 2013-05-09 | Ratiopharm Gmbh | Solid tapentadol in non-crystalline form |
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| HUE029952T2 (en) | 2010-06-30 | 2017-04-28 | Gruenenthal Gmbh | Tapentadol for use in the treatment of irritable bowel syndrome |
| JP5968884B2 (ja) | 2010-07-23 | 2016-08-10 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ３−（３−ジメチルアミノ−１−エチル−２−メチル−プロピル）−フェノールの塩または共結晶 |
| WO2012028319A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
| EP2611425B1 (en) | 2010-09-02 | 2014-07-02 | Grünenthal GmbH | Tamper resistant dosage form comprising an anionic polymer |
| CN107088226A (zh) | 2011-03-04 | 2017-08-25 | 格吕伦塔尔有限公司 | 他喷他多的胃肠外给药 |
| EA025194B1 (ru) | 2011-03-04 | 2016-11-30 | Грюненталь Гмбх | Полутвёрдая фармацевтическая композиция на водной основе, содержащая тапентадол |
| MX388963B (es) | 2011-03-04 | 2025-03-20 | Gruenenthal Gmbh | Formulacion farmaceutica acuosa de tapentadol para administracion oral |
| PT2694050T (pt) | 2011-04-05 | 2019-11-22 | Gruenenthal Gmbh | Tapentadol para uso no tratamento da dor associada à neuralgia trigeminal |
| DK2694049T3 (da) | 2011-04-05 | 2019-01-02 | Gruenenthal Gmbh | Tapentadol til forebyggelse af kronificering af smerte |
| PT2701693T (pt) | 2011-04-29 | 2017-11-16 | Gruenenthal Gmbh | Tapentadol para prevenção e tratamento de depressão e ansiedade |
| US8895623B2 (en) * | 2011-07-29 | 2014-11-25 | Gruenenthal Gmbh | Intrathecal or epidural administration of 3-[(1S,25)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol |
| NO2736495T3 (es) | 2011-07-29 | 2018-01-20 | ||
| US20130028972A1 (en) | 2011-07-29 | 2013-01-31 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
| EP2606879A1 (en) | 2011-12-21 | 2013-06-26 | Hexal AG | Multiple unit pellet tablet formulation comprising an opioid |
| CA2864949A1 (en) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
| EP2838512B1 (en) | 2012-04-18 | 2018-08-22 | Grünenthal GmbH | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| JP6445537B2 (ja) | 2013-05-29 | 2018-12-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形 |
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| EP2845625A1 (en) | 2013-09-04 | 2015-03-11 | Grünenthal GmbH | Tapentadol for use in the treatment of fibromyalgia and chronic fatigue syndrome |
| WO2015071248A1 (en) | 2013-11-15 | 2015-05-21 | Synthon B.V. | Abuse-proofed extended release pharmaceutical composition comprising tapentadol |
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| MX2017013637A (es) | 2015-04-24 | 2018-03-08 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteraciones con liberacion inmediata y resistencia contra la extraccion por solventes. |
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| CN109996533A (zh) | 2016-09-23 | 2019-07-09 | 格吕伦塔尔有限公司 | 用于肠胃外施用他喷他多的稳定制剂 |
| WO2018153947A1 (en) | 2017-02-23 | 2018-08-30 | Grünenthal GmbH | Tapentadol as local anesthetic |
| EP3630074B1 (en) * | 2017-05-29 | 2023-10-25 | Grünenthal GmbH | Multiparticulate oral dosage form providing prolonged release of tapentadol |
| EP3875079A1 (en) | 2020-03-02 | 2021-09-08 | Grünenthal GmbH | Dosage form providing prolonged release of tapentadol phosphoric acid salt |
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| PL3875077T3 (pl) | 2020-03-02 | 2024-03-11 | Grünenthal GmbH | Postać dawkowania zapewniająca przedłużone uwalnianie soli kwasu fosforowego tapentadolu |
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