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PE20030496A1 - 2,5-diamidoindoles sustituidos y su utilizacion - Google Patents

2,5-diamidoindoles sustituidos y su utilizacion

Info

Publication number
PE20030496A1
PE20030496A1 PE2002000947A PE2002000947A PE20030496A1 PE 20030496 A1 PE20030496 A1 PE 20030496A1 PE 2002000947 A PE2002000947 A PE 2002000947A PE 2002000947 A PE2002000947 A PE 2002000947A PE 20030496 A1 PE20030496 A1 PE 20030496A1
Authority
PE
Peru
Prior art keywords
cycloalkyl
dimethylbutanoyl
indol
aryl
amino
Prior art date
Application number
PE2002000947A
Other languages
English (en)
Inventor
Michael Brands
Jens-Kerim Erguden
Dirk Heimbach
Jorg Keldenich
Hanno Wild
Christian Schoder
Stephan Siegel
Johannes-Peter Stasch
Stefan Weigand
Thomas Krahn
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20030496A1 publication Critical patent/PE20030496A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE 2,5-DIAMIDOINDOLES SUSTITUIDOS DE FORMULA I DONDE R1 ES ALQUILO, ALQUENILO, (CH2)nG; G ES CICLOALQUILO, HETEROCICLO; n ES 0-4; R2 ES ALQUILO, CICLOALQUILO(CH2)m, HETEROCICLILO(CH2)m, ARILO(CH2)m, ENTRE OTROS; m ES 0-4; R3 ES CICLOALQUILO(CH2)o, HETEROCICLO(CH2)o, ARILO(CH2)o, ENTRE OTROS; o ES 0-4; R4 ES H, ALQUILO, CICLOALQUILO(CH2)p, HETEROCICLILO(CH2)p, ARILO(CH2)p, HETEROARILO(CH2)p; p ES 0-4. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS AMIDA DEL ACIDO 1-(2,6-DIFLUOROBENCIL)-5-[(3,3-DIMETILBUTANOIL)AMINO]-N-(3-METILFENIL)-1H-INDOL-2-CARBOXILICO; AMIDA DEL ACIDO 1-(2,6-DIFLUOROBENCIL)-5-[(3,3-DIMETILBUTANOIL)AMINO]-N-FENIL-1H-INDOL-2-CARBOXILICO; AMIDA DEL ACIDO 5-[(3,3-DIMETILBUTANOIL)AMINO]-1-(2-FLUOROBENCIL)-N-(3-PIRIDINIL)-1H-INDOL-2-CARBOXILICO, ENTRE OTROS. LOS COMPUESTOS SON INHIBIDORES DE ECE Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, INFARTO DE MIOCARDIO, ANGINA DE PECHO, INSUFICIENCIA CARDIACA
PE2002000947A 2001-09-27 2002-09-26 2,5-diamidoindoles sustituidos y su utilizacion PE20030496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10147672A DE10147672A1 (de) 2001-09-27 2001-09-27 Substituierte 2,5-Diamidoindole und ihre Verwendung

Publications (1)

Publication Number Publication Date
PE20030496A1 true PE20030496A1 (es) 2003-07-13

Family

ID=7700491

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000947A PE20030496A1 (es) 2001-09-27 2002-09-26 2,5-diamidoindoles sustituidos y su utilizacion

Country Status (9)

Country Link
US (1) US7045544B2 (es)
EP (1) EP1432415B1 (es)
JP (1) JP2005508340A (es)
CA (1) CA2461919A1 (es)
DE (2) DE10147672A1 (es)
ES (1) ES2256530T3 (es)
PE (1) PE20030496A1 (es)
UY (1) UY27451A1 (es)
WO (1) WO2003028719A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
AU2003303217A1 (en) * 2002-12-20 2004-07-14 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
EP1479677A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
FR2888847B1 (fr) 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
FR2903985B1 (fr) * 2006-07-24 2008-09-05 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2910473B1 (fr) * 2006-12-26 2009-02-13 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.
EP2078711A1 (en) * 2007-12-28 2009-07-15 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
BRPI0912267A2 (pt) 2008-05-23 2015-10-13 Amira Pharmaceuticals Inc sal farmaceuticamente aceitável, composição farmacêutica, artigo de fabricação, métodos para tratar asma, rinite alérgica, doença, lesões gástricas e dor, métodos para prevenir broncoconstrição e rinite alérgica, uso de um sal farmaceuticamente aceitável, e, processo para a preparação de um sal farmaceuticamente aceitável.
JP2022513310A (ja) * 2018-10-02 2022-02-07 ディスク・メディスン，インコーポレイテッド マトリプターゼ２阻害剤及びその使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0563475B1 (en) 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
FR2745571B1 (fr) * 1996-03-04 1998-06-19 Inst Nat Sante Rech Med Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
ATE271041T1 (de) 1997-05-22 2004-07-15 Scripps Research Inst Analoga von duocarmycin and cc-1065
CA2316172C (en) * 1997-12-24 2010-02-02 Aventis Pharma Deutschland Gmbh Indole derivatives as inhibitors of factor xa

Also Published As

Publication number Publication date
DE10147672A1 (de) 2003-04-10
EP1432415A1 (de) 2004-06-30
US7045544B2 (en) 2006-05-16
US20050038101A1 (en) 2005-02-17
EP1432415B1 (de) 2005-12-28
ES2256530T3 (es) 2006-07-16
UY27451A1 (es) 2003-04-30
WO2003028719A1 (de) 2003-04-10
JP2005508340A (ja) 2005-03-31
DE50205466D1 (de) 2006-02-02
CA2461919A1 (en) 2003-04-10

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