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PE20021046A1 - Sulfonilguanidina que tiene afinidad al punto de fijacion de gabapentina - Google Patents

Sulfonilguanidina que tiene afinidad al punto de fijacion de gabapentina

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Publication number
PE20021046A1
PE20021046A1 PE2001000971A PE2001000971A PE20021046A1 PE 20021046 A1 PE20021046 A1 PE 20021046A1 PE 2001000971 A PE2001000971 A PE 2001000971A PE 2001000971 A PE2001000971 A PE 2001000971A PE 20021046 A1 PE20021046 A1 PE 20021046A1
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PE
Peru
Prior art keywords
alkyl
heteroaryl
cycloalkyl
aryl
amino
Prior art date
Application number
PE2001000971A
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English (en)
Inventor
Boris Chizh
Matthias Gerlach
Heinz Uragg
Corinna Maul
Claudia-Katharina Putz
Michael Haurand
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10048716A external-priority patent/DE10048716A1/de
Priority claimed from DE10112068A external-priority patent/DE10112068A1/de
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20021046A1 publication Critical patent/PE20021046A1/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
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    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/64—X and Y being nitrogen atoms, e.g. N-sulfonylguanidine
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)

Abstract

SE REFIERE AL USO Y A LOS COMPUESTOS DE SULFONILGUANIDINA DE FORMULA (R1)SO2-N=C(NH2)-NR2R3 Y R1SO2-NH-C=NH-NR3R2, DONDE R1 ES ALQUILO C1-C10, CICLOALQUILO C3-C8, ALQUILENO BICICLICO, ARILO, HETEROARILO, R2 ES ALQUILO C1-C10. CICLOALQUILO C3-C8, ARILO, HETEROARILO, NR4R5; SO2R6, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C18, CICLOALQUILO C3-C8, ARILO, HETEROARILO O JUNTOS FORMAN (CH2)2O(CH2)2, (CH2)2NR7(CH2)2; R6 ES ALQUILO C1-C18, CICLOALQUILO C3-C8, ARILO, HETEROARILO; R3 ES H, ALQUILO C1-C10, CICLOALQUILO C3-C8, ARILO, HETEROARILO; R2 Y R3 FORMAN JUNTOS (CH2)(CH2)nCH2, (CH2)2O(CH2)2, (CH2)2NR8(CH2)2; n ES 2-3; R8 ES ALQUILO C1-C18, CICLOALQUILO C3-C8, ALQUENILO BICICLICO, ARILO, HETEROARILO; R7 ES ALQUILO C1-C18, CICLOALQUILO C3-C8, ARILO, HETEROARILO. SON COMPUESTOS PREFERIDOS N-{AMINO-[PIRIDIN-2-ILMETIL-AMINO]METILEN}-4-METILBENCENOSULFONAMIDA; N-[AMINO-(BENCILAMINO-METILEN)]-4-METILBENCENOSULFONAMIDA; QUINOLIN-8-SULFONAMINO-[(PIRIDIN-2-ILMETIL)-AMINO]-METILENAMIDA, ENTRE OTROS. LOS COMPUESTOS TIENEN AFINIDAD AL PUNTO DE FIJACION DE LA GABAPENTINA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DOLOR NEUROPATICO, EPILEPSIA, MIGRANAS, HIPERALGESIA, ALODINIA, DESORDENES POSTMENOPAUSICOS, ESCLEROSIS LATERAL AMIOTROFICA
PE2001000971A 2000-09-30 2001-09-28 Sulfonilguanidina que tiene afinidad al punto de fijacion de gabapentina PE20021046A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10048716A DE10048716A1 (de) 2000-09-30 2000-09-30 Sulfonylguanidine
DE10112068A DE10112068A1 (de) 2001-03-12 2001-03-12 Sulfonylguanidine

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PE20021046A1 true PE20021046A1 (es) 2002-12-14

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EP (1) EP1320520B1 (es)
JP (1) JP4034651B2 (es)
AR (1) AR034160A1 (es)
AT (1) ATE509008T1 (es)
AU (2) AU9385201A (es)
CA (1) CA2424107A1 (es)
HU (1) HUP0303731A3 (es)
MX (1) MXPA03002668A (es)
NZ (1) NZ525252A (es)
PE (1) PE20021046A1 (es)
PL (1) PL207739B1 (es)
WO (1) WO2002030881A1 (es)

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DE60202270T2 (de) * 2001-03-22 2005-05-19 Solvay Pharmaceuticals B.V. 4,5-dihydro-1h-pyrazolderivate mit cb1-antagonistischer wirkung
DK1572173T3 (da) 2002-12-13 2010-06-14 Warner Lambert Co Alpha-2-delta-ligand til behandling af symptomer i den nedre urinvej
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
AU2004271800A1 (en) 2003-09-12 2005-03-24 Pfizer Inc. Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
US20050090549A1 (en) * 2003-10-23 2005-04-28 Medtronic, Inc. Intrathecal gabapentin for treatment of pain
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US20080085900A1 (en) 2008-04-10
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HUP0303731A3 (en) 2006-02-28
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AR034160A1 (es) 2004-02-04
US7671074B2 (en) 2010-03-02
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