PE20020143A1 - Carboxamidas heterociclicas como agentes antivirales - Google Patents
Carboxamidas heterociclicas como agentes antiviralesInfo
- Publication number
- PE20020143A1 PE20020143A1 PE2001000673A PE2001000673A PE20020143A1 PE 20020143 A1 PE20020143 A1 PE 20020143A1 PE 2001000673 A PE2001000673 A PE 2001000673A PE 2001000673 A PE2001000673 A PE 2001000673A PE 20020143 A1 PE20020143 A1 PE 20020143A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- hydroxy
- optionally substituted
- nr10r11
- Prior art date
Links
- 150000003857 carboxamides Chemical class 0.000 title abstract 2
- 239000003443 antiviral agent Substances 0.000 title 1
- 101100212791 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) YBL068W-A gene Proteins 0.000 abstract 3
- CIEWGZJDEDBECJ-UHFFFAOYSA-N 1-chloro-4-methylbenzene Chemical class [CH2]C1=CC=C(Cl)C=C1 CIEWGZJDEDBECJ-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 abstract 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 abstract 1
- 101100134929 Gallus gallus COR9 gene Proteins 0.000 abstract 1
- 208000009889 Herpes Simplex Diseases 0.000 abstract 1
- 208000007514 Herpes zoster Diseases 0.000 abstract 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 abstract 1
- HSLNGLRJQKTINZ-UHFFFAOYSA-N N-[(4-chlorophenyl)methyl]-5-hydroxy-3-(morpholin-4-ylmethyl)quinoline-6-carboxamide Chemical compound C1=C2C(O)=C(C(=O)NCC=3C=CC(Cl)=CC=3)C=CC2=NC=C1CN1CCOCC1 HSLNGLRJQKTINZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A DERIVADOS DE CARBOXAMIDAS HETEROCICLICAS DE FORMULA I, DONDE X ES Cl, Br, F, CN, NO2; G ES ALQUILO C3-C7 OPCIONALMENTE SUSTITUIDO CON OH; ALQUILO C1-C7 SUSTITUIDO CON NR1R2, 4-TETRAHIDROPIRANO; R1 ES ALQUILO C2-C7 SUSTITUIDO CON ALCOXI C1-C4, ARILO, HETEROARILO; R2 ES H, ALQUILO C1-C7 O R1 Y R2 JUNTO CON N FORMAN MORFOLINA OPCIONALMENTE SUSTITUIDO CON ARILO, ALQUILO C1-C7; W ES UN GRUPO w; B ES CR5, C ES CR6, N; B Y C NO SON N; R4 ES H, HALOGENO, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON HALOGENO; R5 ES H, HALO, OR12, SR12, ALQUILO C1-C7, CICLOALQUILO C3-C8 OPCIONALMENTE SUSTITUIDOS CON OR12, NR10R11; COR9; R6 ES H, HALO, ARILO, HET, R7; R7 ES OR12, SR12, ALQUILO C1-C7, NR10R11, ENTRE OTROS; R8 ES H, ALQUILO C1-C7, OR12, SR12; R9 ES ALQUILO C1-C7, NR10R11, ARILO; R10 Y R11 SON H, ARILO, ALQUILO C1-C7, ENTRE OTROS; R12 ES H, ARILO, HET, ENTRE OTROS; m ES 1-2; UTILIZANDOSE DE 0,1mg/Kg A 300mg/Kg. SON COMPUESTOS PREFERIDOS N-(4-CLOROBENCIL)-5-HIDROXI-3-(TETRAHIDRO-2H-PIRAN-4-ILMETIL)-6-ISOQUINOLINCARBOXAMIDA; N-(4-CLOROBENCIL)-5-HIDROXI-3-(3-HIDROXI-1-PROPINIL)-6-ISOQUINOLINCARBOXAMIDA; N-(4-CLOROBENCIL)-5-HIDROXI-3-(4-MORFOLINILMETIL)-6-QUINOLINCARBOXAMIDA. LOS COMPUESTOS SON INHIBIDORES DE POLIMERASA DEL ADN Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE INFECCIONES CON VIRUS HERPES SIMPLEX, VIRUS DE VARICELA ZOSTER, CITOMEGALOVIRUS, VIRUS DE EPSTEIN-BARR
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21755600P | 2000-07-12 | 2000-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020143A1 true PE20020143A1 (es) | 2002-02-15 |
Family
ID=22811560
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000673A PE20020143A1 (es) | 2000-07-12 | 2001-07-06 | Carboxamidas heterociclicas como agentes antivirales |
| PE2001000676A PE20020256A1 (es) | 2000-07-12 | 2001-07-09 | Carboxamidas heterociclicas como agentes antivirales |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000676A PE20020256A1 (es) | 2000-07-12 | 2001-07-09 | Carboxamidas heterociclicas como agentes antivirales |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6730682B2 (es) |
| EP (2) | EP1363907A2 (es) |
| JP (2) | JP2004502769A (es) |
| AR (2) | AR030244A1 (es) |
| AU (2) | AU2001269698A1 (es) |
| PE (2) | PE20020143A1 (es) |
| WO (2) | WO2002004422A2 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60138635D1 (de) | 2000-10-12 | 2009-06-18 | Merck & Co Inc | Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase |
| JP2004517860A (ja) | 2000-10-12 | 2004-06-17 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類 |
| WO2002030426A1 (en) | 2000-10-12 | 2002-04-18 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors |
| EP1375486B1 (en) | 2001-03-01 | 2008-10-15 | Shionogi & Co., Ltd. | Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity |
| AR036256A1 (es) | 2001-08-17 | 2004-08-25 | Merck & Co Inc | Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento |
| ATE370948T1 (de) | 2002-01-17 | 2007-09-15 | Merck & Co Inc | Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen |
| DE60323743D1 (en) | 2002-03-15 | 2008-11-06 | Merck & Co Inc | N-(substituierte benzyl)-8-hydroxy-1,6-naphthyridin-7- carbonsäureamide als hiv-integrase-hemmer |
| AU2003302029B8 (en) * | 2002-11-20 | 2006-08-17 | Japan Tobacco Inc. | 4-oxoquinoline compound and utilization thereof as HIV integrase inhibitor |
| DE10319612A1 (de) | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| DE10320780A1 (de) * | 2003-05-09 | 2005-01-20 | Bayer Healthcare Ag | Heterocyclyl-substituierte Dihydrochinazoline |
| WO2004106334A2 (en) * | 2003-05-28 | 2004-12-09 | Pfizer Products Inc. | Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation |
| DE10352499A1 (de) * | 2003-11-11 | 2005-06-09 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline II |
| DE102004022672A1 (de) * | 2004-05-07 | 2005-11-24 | Bayer Healthcare Ag | Substituierte Azachinazoline |
| US7531554B2 (en) * | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| GB0428475D0 (en) * | 2004-12-30 | 2005-02-02 | 4 Aza Bioscience Nv | Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
| JP2008531709A (ja) | 2005-03-01 | 2008-08-14 | ワイス | シンノリン化合物および肝臓ｘ受容体調節物質としてのそれらの使用 |
| DE102005027517A1 (de) * | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Verfahren zur Herstellung von Dihydrochinazolinen |
| AU2006261607A1 (en) * | 2005-06-24 | 2006-12-28 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis C. |
| EA017861B9 (ru) * | 2006-03-06 | 2014-05-30 | Джапан Тобакко Инк. | Способ получения 4-оксохинолинового соединения |
| US8338435B2 (en) * | 2006-07-20 | 2012-12-25 | Gilead Sciences, Inc. | Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections |
| TW200840584A (en) * | 2006-12-26 | 2008-10-16 | Gilead Sciences Inc | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| WO2008077650A1 (en) * | 2006-12-26 | 2008-07-03 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| US8143394B2 (en) * | 2006-12-26 | 2012-03-27 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| WO2010002998A1 (en) * | 2008-07-03 | 2010-01-07 | Gilead Sciences, Inc. | 2,4,6-TRISUBSTITUTED PYRIDO (3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS |
| EP3317277B1 (en) | 2015-07-01 | 2021-01-20 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| WO2017058242A1 (en) * | 2015-10-02 | 2017-04-06 | United Technologies Corporation | Universal power electronic cell for distributed generation |
| US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| DE202018006413U1 (de) | 2017-08-09 | 2020-04-23 | Sharkninja Operating Llc | Kochgerät und Komponenten davon |
| KR102672512B1 (ko) | 2018-09-12 | 2024-06-10 | 노파르티스 아게 | 항바이러스 피리도피라진디온 화합물 |
| CA3155287A1 (en) | 2019-09-26 | 2021-04-01 | Novartis Ag | Antiviral pyrazolopyridinone compounds |
| WO2021126902A1 (en) * | 2019-12-20 | 2021-06-24 | Merck Sharp & Dohme Corp. | Amido-substituted heterocyclic compounds and methods of use thereof for the treatment of herpes viruses |
| TW202334134A (zh) | 2021-10-28 | 2023-09-01 | 香港商英矽智能科技知識產權有限公司 | 含脯胺醯羥化酶結構域之蛋白質(phd)抑制劑及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0733729A (ja) | 1993-07-26 | 1995-02-03 | Kirin Brewery Co Ltd | Ｎ−シアノ−ｎ′−置換−アリールカルボキシイミダミド化合物の製造法 |
| JPH08301849A (ja) | 1995-05-01 | 1996-11-19 | Takeda Chem Ind Ltd | ヘテロ環化合物およびその製造法 |
| PT841929E (pt) | 1995-08-02 | 2003-09-30 | Darwin Discovery Ltd | Quinolonas e sua utilizacao terapeutica |
| JPH11510156A (ja) | 1995-08-02 | 1999-09-07 | カイロサイエンス・リミテッド | キノロン類およびその医療上の使用 |
| GB9605437D0 (en) | 1996-03-15 | 1996-05-15 | Iaf Biochem Int | Cytomegalovirus inhibiting compounds |
| US5945431A (en) | 1996-03-15 | 1999-08-31 | Biochem Therapeutics Incorporated | Cytomegalovirus inhibiting compounds |
| US6310211B1 (en) | 1996-09-10 | 2001-10-30 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| US5932618A (en) | 1996-11-04 | 1999-08-03 | Signal Pharmaceuticals, Inc. | Anti-viral agents and methods relating to the use thereof |
| NZ502548A (en) | 1997-08-25 | 2002-06-28 | Neurogen Corp | Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands |
| RU2220960C2 (ru) | 1997-12-22 | 2004-01-10 | Фармация Энд Апджон Компани | 4-гидрокси-3-хинолинкарбоксамиды и гидразиды, фармацевтическая композиция и способ лечения на их основе |
| JP2000256323A (ja) | 1999-01-08 | 2000-09-19 | Japan Tobacco Inc | ２−オキソキノリン化合物及びその医薬用途 |
| US6248736B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents |
| US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| PT1159279E (pt) | 1999-03-09 | 2003-02-28 | Upjohn Co | 4-oxo-4,7-di-hidrotieno¬2,3-b|piridino-5-carboxamidas como agentes antivirais |
-
2001
- 2001-06-22 US US09/887,620 patent/US6730682B2/en not_active Expired - Fee Related
- 2001-06-25 AU AU2001269698A patent/AU2001269698A1/en not_active Abandoned
- 2001-06-25 AU AU2001269697A patent/AU2001269697A1/en not_active Abandoned
- 2001-06-25 WO PCT/US2001/016491 patent/WO2002004422A2/en not_active Application Discontinuation
- 2001-06-25 JP JP2002509308A patent/JP2004502769A/ja active Pending
- 2001-06-25 EP EP01948225A patent/EP1363907A2/en not_active Withdrawn
- 2001-06-25 EP EP01948224A patent/EP1299360A2/en not_active Withdrawn
- 2001-06-25 JP JP2002509289A patent/JP2004502758A/ja active Pending
- 2001-06-25 WO PCT/US2001/016492 patent/WO2002004443A2/en not_active Application Discontinuation
- 2001-07-05 AR ARP010103210A patent/AR030244A1/es not_active Application Discontinuation
- 2001-07-05 AR ARP010103209A patent/AR030243A1/es not_active Application Discontinuation
- 2001-07-06 PE PE2001000673A patent/PE20020143A1/es not_active Application Discontinuation
- 2001-07-09 PE PE2001000676A patent/PE20020256A1/es not_active Application Discontinuation
-
2004
- 2004-03-29 US US10/812,229 patent/US20040180910A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002004443A3 (en) | 2003-09-12 |
| AR030243A1 (es) | 2003-08-13 |
| AU2001269697A1 (en) | 2002-01-21 |
| JP2004502769A (ja) | 2004-01-29 |
| US20040180910A1 (en) | 2004-09-16 |
| US20020019397A1 (en) | 2002-02-14 |
| WO2002004422A2 (en) | 2002-01-17 |
| WO2002004422A3 (en) | 2002-06-20 |
| AR030244A1 (es) | 2003-08-13 |
| JP2004502758A (ja) | 2004-01-29 |
| AU2001269698A1 (en) | 2002-01-21 |
| EP1299360A2 (en) | 2003-04-09 |
| EP1363907A2 (en) | 2003-11-26 |
| PE20020256A1 (es) | 2002-03-23 |
| WO2002004443A2 (en) | 2002-01-17 |
| US6730682B2 (en) | 2004-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |