PE20020667A1 - Derivados de piperazina como ligandos del receptor 5ht2 - Google Patents
Derivados de piperazina como ligandos del receptor 5ht2Info
- Publication number
- PE20020667A1 PE20020667A1 PE2001001247A PE2001001247A PE20020667A1 PE 20020667 A1 PE20020667 A1 PE 20020667A1 PE 2001001247 A PE2001001247 A PE 2001001247A PE 2001001247 A PE2001001247 A PE 2001001247A PE 20020667 A1 PE20020667 A1 PE 20020667A1
- Authority
- PE
- Peru
- Prior art keywords
- aryl
- piperazine
- cycloalkyl
- aralkyl
- alkyl
- Prior art date
Links
- 108091005479 5-HT2 receptors Proteins 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- DVAFBRQCRKGRDW-UHFFFAOYSA-N piperazine-1-carbothioic s-acid Chemical compound SC(=O)N1CCNCC1 DVAFBRQCRKGRDW-UHFFFAOYSA-N 0.000 abstract 2
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 229940086609 Lipase inhibitor Drugs 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 abstract 1
- 229960001243 orlistat Drugs 0.000 abstract 1
- 201000002859 sleep apnea Diseases 0.000 abstract 1
Classifications
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
SE REFIERE A DERIVADOS DE PIPERAZINA DE FORMULA I DONDE R1 Y R2 SON H, ALQUILO, CICLOALQUILO, ARILO, ARALQUILO O FORMAN UN ANILLO CARBOCICLICO DE 3-8 MIEMBROS OPCIONALMENTE SUSTITUIDO POR ALQUILO; R3 Y R4 SON H, ALQUILO, CICLOALQUILO, ARILO, ARALQUILO; A1 ES O, S; A1 ES O, A2 ES FENILO SIN SUSTITUIR UNO DE R1, R2, R3, R4 NO ES H; A2 ES ARILO, HETEROARILO, CICLOALQUILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO, CICLOALQUILO, ARILO, ARALQUILO, ALCOXILO, ENTRE OTROS; n ES 1-2; m ES 0-1; EXCEPTO EL COMPUESTO ESTER (4-NITROFENIL)-METILICO DEL ACIDO 2 METIL-1-PIPERAZINACARBOXILICO ESTER (4-(TRIFLUOROMETIL)FENIL)METILICO DEL ACIDO 1-PIPERAZINA CARBOXILICO. SON COMPUESTOS PREFERIDOS PIPERAZINA-1-TIOCARBOXILATO DE S-4-[(2-PROPILAMINO)-CARBONIL]OXIBENCILO; PIPERAZINA-1-TIOCARBOXILATO DE S-4-[(BENCILAMINO)-CARBONIL]OXIBENCILO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. TAMBIEN SE REFIERE AL USO CON UN INHIBIDOR DE LIPASAS COMO ORLISTAT. LOS COMPUESTOS SON LIGANDOS DEL RECEPTOR 5HT2 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE TRASTORNOS ALIMENTARIOS, DIABETES, SISTEMA NERVIOSO CENTRAL, CARDIOVASCULARES, GASTROINTESTINALES, APNEA DEL SUENO, OBESIDAD
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0030710.8A GB0030710D0 (en) | 2000-12-15 | 2000-12-15 | Piperazine derivatives |
Publications (1)
Publication Number | Publication Date |
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PE20020667A1 true PE20020667A1 (es) | 2002-07-27 |
Family
ID=9905222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PE2001001247A PE20020667A1 (es) | 2000-12-15 | 2001-12-13 | Derivados de piperazina como ligandos del receptor 5ht2 |
Country Status (19)
Country | Link |
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US (2) | US20020143020A1 (es) |
EP (1) | EP1343775B1 (es) |
JP (1) | JP4047724B2 (es) |
KR (1) | KR100623833B1 (es) |
CN (1) | CN1277824C (es) |
AR (1) | AR035517A1 (es) |
AT (1) | ATE397595T1 (es) |
AU (1) | AU2962602A (es) |
BR (1) | BR0116201A (es) |
CA (1) | CA2430601C (es) |
DE (1) | DE60134338D1 (es) |
ES (1) | ES2306736T3 (es) |
GB (1) | GB0030710D0 (es) |
MX (1) | MXPA03005270A (es) |
PA (1) | PA8534801A1 (es) |
PE (1) | PE20020667A1 (es) |
UY (1) | UY27075A1 (es) |
WO (1) | WO2002048124A2 (es) |
ZA (1) | ZA200304346B (es) |
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- 2000-12-15 GB GBGB0030710.8A patent/GB0030710D0/en not_active Ceased
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2001
- 2001-12-06 WO PCT/EP2001/014343 patent/WO2002048124A2/en active IP Right Grant
- 2001-12-06 BR BR0116201-2A patent/BR0116201A/pt not_active IP Right Cessation
- 2001-12-06 AT AT01990522T patent/ATE397595T1/de not_active IP Right Cessation
- 2001-12-06 CN CNB018206115A patent/CN1277824C/zh not_active Expired - Fee Related
- 2001-12-06 JP JP2002549655A patent/JP4047724B2/ja not_active Expired - Fee Related
- 2001-12-06 DE DE60134338T patent/DE60134338D1/de not_active Expired - Lifetime
- 2001-12-06 ES ES01990522T patent/ES2306736T3/es not_active Expired - Lifetime
- 2001-12-06 EP EP01990522A patent/EP1343775B1/en not_active Expired - Lifetime
- 2001-12-06 MX MXPA03005270A patent/MXPA03005270A/es unknown
- 2001-12-06 KR KR1020037008003A patent/KR100623833B1/ko not_active Expired - Fee Related
- 2001-12-06 AU AU2962602A patent/AU2962602A/xx active Pending
- 2001-12-06 CA CA002430601A patent/CA2430601C/en not_active Expired - Fee Related
- 2001-12-07 US US10/010,058 patent/US20020143020A1/en not_active Abandoned
- 2001-12-12 AR ARP010105788A patent/AR035517A1/es not_active Application Discontinuation
- 2001-12-12 PA PA20018534801A patent/PA8534801A1/es unknown
- 2001-12-13 PE PE2001001247A patent/PE20020667A1/es not_active Application Discontinuation
- 2001-12-14 UY UY27075A patent/UY27075A1/es not_active Application Discontinuation
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2003
- 2003-06-03 ZA ZA200304346A patent/ZA200304346B/en unknown
-
2004
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Also Published As
Publication number | Publication date |
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JP2004519438A (ja) | 2004-07-02 |
MXPA03005270A (es) | 2003-09-25 |
AR035517A1 (es) | 2004-06-02 |
ZA200304346B (en) | 2004-09-03 |
WO2002048124A3 (en) | 2003-06-05 |
UY27075A1 (es) | 2002-07-31 |
JP4047724B2 (ja) | 2008-02-13 |
KR100623833B1 (ko) | 2006-09-18 |
CN1533382A (zh) | 2004-09-29 |
ATE397595T1 (de) | 2008-06-15 |
AU2962602A (en) | 2002-06-24 |
EP1343775B1 (en) | 2008-06-04 |
ES2306736T3 (es) | 2008-11-16 |
BR0116201A (pt) | 2004-03-02 |
GB0030710D0 (en) | 2001-01-31 |
US20040235859A1 (en) | 2004-11-25 |
US7022707B2 (en) | 2006-04-04 |
KR20030072563A (ko) | 2003-09-15 |
WO2002048124A2 (en) | 2002-06-20 |
CN1277824C (zh) | 2006-10-04 |
DE60134338D1 (de) | 2008-07-17 |
CA2430601A1 (en) | 2002-06-20 |
US20020143020A1 (en) | 2002-10-03 |
PA8534801A1 (es) | 2002-08-26 |
CA2430601C (en) | 2008-05-06 |
EP1343775A2 (en) | 2003-09-17 |
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