PE20011185A1 - Derivados de pirrolidin y piperidin - Google Patents
Derivados de pirrolidin y piperidinInfo
- Publication number
- PE20011185A1 PE20011185A1 PE2001000354A PE2001000354A PE20011185A1 PE 20011185 A1 PE20011185 A1 PE 20011185A1 PE 2001000354 A PE2001000354 A PE 2001000354A PE 2001000354 A PE2001000354 A PE 2001000354A PE 20011185 A1 PE20011185 A1 PE 20011185A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrrolidin
- phenyl
- piperidin
- phenol
- butyl
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title abstract 3
- -1 4-PHENYL-BUTYL Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 210000004556 brain Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIRROLIDIN Y PIPERIDIN DE FORMULA I DONDE Ar1 ES PIRIDILO, FENILO CON OH, ALQUILO, HALOGENO, GRUPO a, ENTRE OTROS; DONDE Z1 ES ANILLO HETEROCICLICO DE 5 MIEMBROS; R1 ES H, OH, OXO; Ar2 ES PIRIDILO, FENILO CON OH, ALQUILO, HALOGENO, ENTRE OTROS; Q ES S, SO, SO2; X ES UN ENLACE, -CH(OH)-, -(CH2)n-; A ES UN ENLACE, -(CHR)m-; R ES H, HALOGENO, OH, m ES 2-3; Y ES -(CR2)m, -O-, -C=C-, PIPERIDIN-1-ILO, PIRROLIDIN-1-ILO, C4-C6-CICLOALQUILO, ENTRE OTROS; B ES UN ENLACE, -O-, -(CHR)m; n ES 1-2; m ES 1-3. SON COMPUESTOS PREFERIDOS (S)-4-[1-(4-FENIL-BUTIL)-PIRROLIDIN-3-IL-SULFANIL]-FENOL, (RS)-4-[1-(4-FENIL-BUTIL)-PIRROLIDIN-3-IL-SULFANIL]-FENOL, (R)-4-[1-(4-FENIL-BUTIL)-PIRROLIDIN-3-IL-SULFANIL]-FENOL,(2R,3S) o (2S,3S)-4-[1-(2-HIDROXI-4-FENIL-BUTIL)-PIRROLIDIN-3-IL-SULFANIL]-FENOL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION. LOS DERIVADOS DE PIRROLIDIN Y PIPERIDIN ACTUAN COMO BLOQUEADORES ESPECIFICOS DEL SUBTIPO DE RECEPTORES DEL N-METIL-D-ASPARTATO (NMDA) Y SON UTILES PARA EL TRATAMIENTO DE NEURODEGENERACION CAUSADAS POR TRAUMA, CRISIS CEREBRALES, ALZHEIMER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00108610 | 2000-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011185A1 true PE20011185A1 (es) | 2001-11-14 |
Family
ID=8168522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000354A PE20011185A1 (es) | 2000-04-20 | 2001-04-18 | Derivados de pirrolidin y piperidin |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6451819B2 (es) |
| EP (1) | EP1278728B1 (es) |
| JP (1) | JP4219590B2 (es) |
| KR (1) | KR100501606B1 (es) |
| CN (1) | CN1178911C (es) |
| AR (1) | AR028343A1 (es) |
| AT (1) | ATE274494T1 (es) |
| AU (2) | AU7394201A (es) |
| BR (1) | BR0110112A (es) |
| CA (1) | CA2404464C (es) |
| DE (1) | DE60105144T2 (es) |
| ES (1) | ES2225553T3 (es) |
| MX (1) | MXPA02010261A (es) |
| PE (1) | PE20011185A1 (es) |
| PT (1) | PT1278728E (es) |
| TR (1) | TR200402442T4 (es) |
| WO (1) | WO2001081303A1 (es) |
| ZA (1) | ZA200208015B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID27178A (id) * | 1998-04-01 | 2001-03-08 | Nortran Pharmaceuticals Inc | Senyawa aminosikloheksil eter dan penggunaannya |
| US6979685B1 (en) * | 1999-02-12 | 2005-12-27 | Cardiome Pharma Corp. | Cycloalkyl amine compounds and uses thereof |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7199147B2 (en) | 2001-06-12 | 2007-04-03 | Dainippon Sumitomo Pharma Co., Ltd. | Rho kinase inhibitors |
| US6885903B2 (en) * | 2001-07-10 | 2005-04-26 | General Electric Company | Method and system for tracking repair of components |
| EP1467986A1 (en) * | 2002-01-17 | 2004-10-20 | Eli Lilly And Company | Aza-cyclic compounds as modulators of acetylcholine receptors |
| US7005432B2 (en) * | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
| GB2410480B (en) * | 2002-10-31 | 2006-05-31 | Fabio Pedrini | Vehicle-mounted equipment carrier |
| WO2004099137A1 (en) * | 2003-05-02 | 2004-11-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| US7345086B2 (en) * | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| WO2005018635A2 (en) * | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| GB0325956D0 (en) * | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| WO2005113011A2 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| EP1868598B1 (en) * | 2004-11-08 | 2014-04-23 | Cardiome Pharma Corp. | A new dosing regimen for ion channel modulating compounds for treating acute atrial fibrillation in a human |
| RU2499598C2 (ru) * | 2008-03-27 | 2013-11-27 | Евотек Интернациональ Гмбх | Способы лечения нарушений с применением селективного антагониста nr2b-подтипа nmda рецепторов |
| AU2009323766B2 (en) | 2008-12-02 | 2016-10-06 | Wave Life Sciences Ltd. | Method for the synthesis of phosphorus atom modified nucleic acids |
| RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
| JP5868324B2 (ja) * | 2010-09-24 | 2016-02-24 | 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ | 不斉補助基 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | キラル制御 |
| CN104684923B (zh) | 2012-07-13 | 2018-09-28 | 株式会社新日本科学 | 手性核酸佐剂 |
| JP6268157B2 (ja) | 2012-07-13 | 2018-01-24 | 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ | 不斉補助基 |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| AU2015207773B2 (en) | 2014-01-16 | 2021-06-17 | Wave Life Sciences Ltd. | Chiral design |
| ES2940904T3 (es) * | 2014-07-10 | 2023-05-12 | SpecGx LLC | Procedimiento para preparar fenilalcanos sustituidos |
| WO2024099403A1 (zh) * | 2022-11-10 | 2024-05-16 | 北京普祺医药科技股份有限公司 | 一种具有软药性质的硫醚类化合物、药物组合物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL74140A (en) * | 1984-04-10 | 1988-05-31 | Robins Co Inc A H | Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them |
| ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
| US6015824A (en) * | 1998-02-10 | 2000-01-18 | Hoffmann-La Roche Ag | Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders |
| TWI254043B (en) * | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
-
2001
- 2001-04-11 AU AU7394201A patent/AU7394201A/xx active Pending
- 2001-04-11 KR KR10-2002-7014043A patent/KR100501606B1/ko not_active Expired - Fee Related
- 2001-04-11 DE DE60105144T patent/DE60105144T2/de not_active Expired - Fee Related
- 2001-04-11 AT AT01940321T patent/ATE274494T1/de not_active IP Right Cessation
- 2001-04-11 WO PCT/EP2001/004171 patent/WO2001081303A1/en active IP Right Grant
- 2001-04-11 MX MXPA02010261A patent/MXPA02010261A/es active IP Right Grant
- 2001-04-11 JP JP2001578398A patent/JP4219590B2/ja not_active Expired - Fee Related
- 2001-04-11 AU AU2001273942A patent/AU2001273942B2/en not_active Ceased
- 2001-04-11 BR BR0110112-9A patent/BR0110112A/pt not_active IP Right Cessation
- 2001-04-11 TR TR2004/02442T patent/TR200402442T4/xx unknown
- 2001-04-11 CA CA002404464A patent/CA2404464C/en not_active Expired - Fee Related
- 2001-04-11 ES ES01940321T patent/ES2225553T3/es not_active Expired - Lifetime
- 2001-04-11 PT PT01940321T patent/PT1278728E/pt unknown
- 2001-04-11 CN CNB018083099A patent/CN1178911C/zh not_active Expired - Fee Related
- 2001-04-11 EP EP01940321A patent/EP1278728B1/en not_active Expired - Lifetime
- 2001-04-12 US US09/833,450 patent/US6451819B2/en not_active Expired - Fee Related
- 2001-04-18 AR ARP010101809A patent/AR028343A1/es unknown
- 2001-04-18 PE PE2001000354A patent/PE20011185A1/es not_active Application Discontinuation
-
2002
- 2002-10-04 ZA ZA200208015A patent/ZA200208015B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1278728B1 (en) | 2004-08-25 |
| AU7394201A (en) | 2001-11-07 |
| WO2001081303A1 (en) | 2001-11-01 |
| EP1278728A1 (en) | 2003-01-29 |
| ZA200208015B (en) | 2004-02-10 |
| DE60105144T2 (de) | 2005-09-08 |
| JP2003531190A (ja) | 2003-10-21 |
| AR028343A1 (es) | 2003-05-07 |
| KR20030013387A (ko) | 2003-02-14 |
| ATE274494T1 (de) | 2004-09-15 |
| AU2001273942B2 (en) | 2005-09-01 |
| ES2225553T3 (es) | 2005-03-16 |
| CA2404464A1 (en) | 2001-11-01 |
| BR0110112A (pt) | 2003-02-11 |
| KR100501606B1 (ko) | 2005-07-18 |
| JP4219590B2 (ja) | 2009-02-04 |
| TR200402442T4 (tr) | 2004-12-21 |
| CN1178911C (zh) | 2004-12-08 |
| DE60105144D1 (de) | 2004-09-30 |
| MXPA02010261A (es) | 2003-04-25 |
| PT1278728E (pt) | 2004-10-29 |
| CN1425002A (zh) | 2003-06-18 |
| CA2404464C (en) | 2008-03-11 |
| US6451819B2 (en) | 2002-09-17 |
| US20010047031A1 (en) | 2001-11-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20011185A1 (es) | Derivados de pirrolidin y piperidin | |
| ES507142A0 (es) | Un procedimiento para la preparacion del enantiomero (-) de la n-metil-3-(2metilfenoxi)-3-fenilpropilamina. | |
| ES2104733T3 (es) | Derivados de indol. | |
| EE200300029A (et) | Fosfonaatnukleotiidanaloogide eelravimid ning meetodid nende valimiseks ning valmistamiseks | |
| CO4700472A1 (es) | Pirimidindiona, pirimidintriona, triacindiona, tetrahidroquinazolindion como antagonistas alfa 1 adrenoreceptores | |
| CY1107974T1 (el) | Παραγωγα κινολινης και κιναζολινης εχοντα συναφεια προς τους υποδοχεις τυπου 5ht1 | |
| DK0640592T3 (da) | N-acylerede tricycliske azaheteroringe anvendelige som vasopressin-antagonister | |
| DOP2002000433A (es) | 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituidas y su uso | |
| PT1919475E (pt) | Derivados de tetrahidro-â-carbolino-sulfonamida de como ligandos de 5-ht6 | |
| NZ544244A (en) | Dual NK1/NK3 antagonists for treating schizophrenia | |
| PE109598A1 (es) | Pirrolcarboxamidas condensadas, utiles como ligandos de receptores cerebrales gaba | |
| ECSP088326A (es) | Derivados de benzotiazol ciclobutil amina y su uso como ligandos de los receptores 3 de histamina | |
| ES2170735B2 (es) | Metodo para la preparacion de citalopram. | |
| NO20023978L (no) | 8,8A-dihydro-indeno(1,2-D)tiazolderivater, substituert i posisjon 8A, en fremgangsmåte for deres fremstilling og deresanvendelse som legemidler, for eksempel anoreksimidler | |
| NZ528997A (en) | Sulfonamides | |
| NO20054135L (no) | Kipolinon/benzoksazin derivater og anvendelser derav | |
| DE69933885D1 (de) | Triphenylbutenderivate zur behandlung von neurologischen störungen | |
| ES2152278T3 (es) | Compuestos de ciclopentadienilmagnesio puenteados y procesos para su preparacion y su aplicacion para la preparacion de metalocenos. | |
| ECSP024377A (es) | Derivados de benzo (g) quinolina | |
| CO5011066A1 (es) | Compuestos de triazina | |
| SV2004001419A (es) | Procedimientos para la preparacion de derivados biciclicos sustituidos para el tratamiento del crecimiento celular anormal" ref.pc23005 | |
| IE872090L (en) | 1,4-dihydropyridines | |
| DE602004003737D1 (de) | Verfahren zur Herstellung von disubstituierten 9-Alkylidenfluorenen und deren Derivaten. | |
| DE60100811D1 (de) | Crf rezeptor-antagonisten und darauf bezogene methoden | |
| YU74601A (sh) | POSTUPAK ZA DOBIJANJE (S-(R*,S*)]-p-[[[1-OkSO-3-(4-PIPERIDINIL)PROPIL]-3-PIPERIDINIL]KARBONIL]AMINO]-3-PIPERIDINPROPIONSKE KISELINE I NJENIH DERIVATA |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |