PE20010165A1 - Derivados de 1-trifluorometil-4-hidroxi-7-piperidinil-aminometilcromano como antagonistas de la sustancia p - Google Patents
Derivados de 1-trifluorometil-4-hidroxi-7-piperidinil-aminometilcromano como antagonistas de la sustancia pInfo
- Publication number
- PE20010165A1 PE20010165A1 PE2000000472A PE0004722000A PE20010165A1 PE 20010165 A1 PE20010165 A1 PE 20010165A1 PE 2000000472 A PE2000000472 A PE 2000000472A PE 0004722000 A PE0004722000 A PE 0004722000A PE 20010165 A1 PE20010165 A1 PE 20010165A1
- Authority
- PE
- Peru
- Prior art keywords
- hydroxy
- aminometilcromano
- piperidinyl
- derivatives
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 108090000189 Neuropeptides Proteins 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000022821 personality disease Diseases 0.000 abstract 1
- 208000019899 phobic disease Diseases 0.000 abstract 1
- 208000028173 post-traumatic stress disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Endocrinology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
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Abstract
SE REFIERE A DERIVADOS DE 1-TRIFLUOROMETIL-4-HIDROXI-7-PIPERIDINIL-AMINOMETILCROMANO DE FORMULA I, DONDE: R1 ES UN ALQUILO C1-C6, R2 ES H, ALQUILO C1-C6, HALOALQUILO C1-C6, FENILO; R3 ES H, HALO; R4 Y R5 SON H, ALQUILO C1-C6, HALOALQUILO C1-C6. UN COMPUESTO PREFERIDO ES (2S,3S)-3-(6-METOXI-4-HIDROXI-1-METILO-1-TRIFLUOROMETILISOCROMAN-7-IL)METILAMINO-2-FENIL]PIPERIDINA. LOS DERIVADOS DE 1-TRIFLUROMETIL-4-HIDROXI-7-PIPERIDINIL-AMINOMETILCROMANO SON ANTAGONISTAS DE NEUROPEPTIDOS, SUSTANCIA P POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNO DEPRESIVO GRAVE, DEPRESION PEDIATRICA, TRASTORNO DE ANSIEDAD, TRASTORNO OBSESIVO-COMPULSIVO, TRASTORNO DE PANICO, FOBIAS, TRASTORNO DEL ESTRES POSTRAUMATICO, TRASTORNO DE PERSONALIDAD
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13539999P | 1999-05-21 | 1999-05-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010165A1 true PE20010165A1 (es) | 2001-02-20 |
Family
ID=22467939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000472A PE20010165A1 (es) | 1999-05-21 | 2000-05-19 | Derivados de 1-trifluorometil-4-hidroxi-7-piperidinil-aminometilcromano como antagonistas de la sustancia p |
Country Status (49)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW426667B (en) * | 1997-11-19 | 2001-03-21 | Pfizer | Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists |
| ATE257477T1 (de) * | 1999-10-18 | 2004-01-15 | Pfizer Prod Inc | Verfahren zur herstellung von zyklischen piperidinylaminomethyl-trifluoromethyl- etherderivaten |
| DE10311984A1 (de) * | 2003-03-12 | 2004-09-23 | Freie Universität Berlin | Verwendung von NEP-assoziierten Molekülen zur Behandlung von nichtimmunogenen-nichthypertensiven Zivilisationskrankheiten |
| US7122700B2 (en) * | 2004-07-30 | 2006-10-17 | Xerox Corporation | Arylamine processes |
| US7868016B2 (en) * | 2005-07-13 | 2011-01-11 | Baxter International Inc. | Pharmaceutical formulations of endo-N-(9-methyl-9-azabicyclo[3,3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride |
| WO2009109001A1 (en) * | 2008-03-04 | 2009-09-11 | Adelaide Research & Innovation Pty Ltd | Method for preventing and/or treating a disease, condition or state associated with reduced dopaminergic neuron function |
| KR101728175B1 (ko) | 2008-06-25 | 2017-04-18 | 어레이 바이오파마 인크. | 6-치환 페녹시크로만 카르복실릭 애시드 유도체 |
| CN117343036A (zh) * | 2023-03-20 | 2024-01-05 | 江苏联环药业股份有限公司 | 异苯并二氢吡喃类化合物及其药物组合物和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| GB9317987D0 (en) * | 1993-08-26 | 1993-10-13 | Glaxo Group Ltd | Chemical compounds |
| KR19980703354A (ko) * | 1995-03-27 | 1998-10-15 | 나카토미히로타카 | 피페리딘 유도체 |
| RU2156250C2 (ru) * | 1995-04-24 | 2000-09-20 | Новартис Аг | Производные хромона, способ их получения и фармацевтическая композиция |
| US6180647B1 (en) * | 1995-07-07 | 2001-01-30 | Pfizer Inc. | Substituted benzolactam compounds as substance P antagonists |
| TW340842B (en) * | 1995-08-24 | 1998-09-21 | Pfizer | Substituted benzylaminopiperidine compounds |
| TW426667B (en) * | 1997-11-19 | 2001-03-21 | Pfizer | Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists |
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2000
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