PE20010634A1 - Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen - Google Patents
Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienenInfo
- Publication number
- PE20010634A1 PE20010634A1 PE2000001064A PE0010642000A PE20010634A1 PE 20010634 A1 PE20010634 A1 PE 20010634A1 PE 2000001064 A PE2000001064 A PE 2000001064A PE 0010642000 A PE0010642000 A PE 0010642000A PE 20010634 A1 PE20010634 A1 PE 20010634A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- imidazo
- cycloalkyl
- butyl
- alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- -1 BUTYL Chemical group 0.000 abstract 8
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 241000347391 Umbrina cirrosa Species 0.000 abstract 1
- ZHZZWIQPCAMTIM-UHFFFAOYSA-N [C]1=CC=CC2=CC=CC=C12 Chemical class [C]1=CC=CC2=CC=CC=C12 ZHZZWIQPCAMTIM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical group C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A IMIDAZO-3-ILAMINAS BICICLICAS SUSTITUIDAS DE FORMULA I, DONDE X E Y SON CH, N, X E Y NO SON N A LA VEZ; R1 ES BUTILO, (CH2)nCN, FENILO, CICLOALQUILO C4-C8, CH2CH2R, CH2Ra, 1,1,3,3-TETRAMETILBUTILO, ENTRE OTROS; n ES 4-6; R ES 4-MORFOLINO; Ra ES H, OH, ALQUILO C1-C8, FENILO, ENTRE OTROS; R2 ES H, CORb; Rb ES ALQUILO C1-C4, CICLOALQUILO C3-C8, CH2CH2CO(ORc); Rc ES ALQUILO C1-C4, ADAMANTILO, FENILO, 1-NAFTILO, TIAZOLILO, CH2CH2Rd, ENTRE OTROS; Rd ES FENILO, CONHRe; Re ES ALQUILO C1-C8, CICLOALQUILO C3-C8, FENILO; R3 ES METILO, ETILO, BUTILO, CICLOALQUILO C3-C8, ENTRE OTROS; CON LA CONDICION QUE R3 NO ES n-PROPILO, CICLOHEXILO, FENILO; CUANDO R1 ES t-BUTILO, n-PROPILO, n-BUTILO, CH2CH2R, ENTRE OTROS Y R2 ES H, CO-METILO Y R2 NO ES H CUANDO R1 ES BENCILO Y R3 ES METILO O R1 ES CH2COBUTILO Y R3 ES FENILO. SON COMPUESTOS PREFERIDOS (6-ISOCIANO-HEXIL)-2-PIRIDIN-2-IL-IMIDAZO[1,3-a]PIRIDIN-3-IL)AMINA, (2-FURAN-2-IL-IMIDAZO[1,2-a]PIRIDIN-3-IL)-(6-ISOCIANO-HEXIL)-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DEL DOLOR
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19948434A DE19948434A1 (de) | 1999-10-08 | 1999-10-08 | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
| DE1999148438 DE19948438B4 (de) | 1999-10-08 | 1999-10-08 | Bicyclische Imidazo-3-aminderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010634A1 true PE20010634A1 (es) | 2001-07-07 |
Family
ID=26055218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001064A PE20010634A1 (es) | 1999-10-08 | 2000-10-06 | Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6638933B2 (es) |
| EP (1) | EP1218382B1 (es) |
| JP (1) | JP2003511451A (es) |
| KR (1) | KR100756592B1 (es) |
| CN (1) | CN1257169C (es) |
| AR (1) | AR025962A1 (es) |
| AT (1) | ATE258554T1 (es) |
| AU (1) | AU779197B2 (es) |
| BR (1) | BR0014818A (es) |
| CA (1) | CA2382919C (es) |
| CO (1) | CO5251378A1 (es) |
| CZ (1) | CZ20021210A3 (es) |
| DE (1) | DE50005155D1 (es) |
| DK (1) | DK1218382T3 (es) |
| ES (1) | ES2213611T3 (es) |
| HK (1) | HK1047747B (es) |
| HU (1) | HUP0203052A3 (es) |
| NO (1) | NO322754B1 (es) |
| NZ (2) | NZ518390A (es) |
| PE (1) | PE20010634A1 (es) |
| PL (1) | PL355206A1 (es) |
| PT (1) | PT1218382E (es) |
| RU (1) | RU2264402C2 (es) |
| SK (1) | SK286788B6 (es) |
| UY (1) | UY26372A1 (es) |
| WO (1) | WO2001027111A2 (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077605A1 (en) * | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| DE10043845A1 (de) * | 2000-09-06 | 2002-03-14 | Gruenenthal Gmbh | Verfahren zur Messung der Aktivität der NO-Synthase |
| EP1854798A3 (en) | 2000-09-19 | 2007-11-28 | Bristol-Myers Squibb Company | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| WO2002048146A2 (de) * | 2000-12-13 | 2002-06-20 | Basf Aktiengesellschaft | Verwendung von substituierten imidazoazinen, neue imidazoazine, verfahren zu deren herstellung, sowie sie enthaltende mittel |
| US20040087548A1 (en) | 2001-02-27 | 2004-05-06 | Salvati Mark E. | Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| PL206962B1 (pl) | 2001-12-19 | 2010-10-29 | Bristol Myers Squibb Co | Związek heterocykliczny o budowie skondensowanej |
| DE102004021716A1 (de) * | 2004-04-30 | 2005-12-01 | Grünenthal GmbH | Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen |
| AU2005251408A1 (en) * | 2004-06-09 | 2005-12-22 | Oncalis Ag | Protein kinase inhibitors |
| US7923041B2 (en) * | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| PT1863818E (pt) * | 2005-03-23 | 2010-04-09 | Hoffmann La Roche | Derivados de acetilenil-pirazolo-pirimidina como antagonistas de mglur2 |
| US7566716B2 (en) * | 2005-05-20 | 2009-07-28 | Array Biopharma Inc. | Imidazopyrazines as Raf inhibitor compounds |
| EP1901748B1 (en) * | 2005-06-09 | 2010-09-08 | Oncalis AG | Angiogenesis inhibitors |
| CA2620223A1 (en) | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
| AU2006331363B2 (en) * | 2005-12-27 | 2012-07-05 | F. Hoffmann-La Roche Ag | Aryl-isoxazol-4-yl-imidazo[1, 5-a]pyridine derivatives |
| EP1979350A1 (en) * | 2006-01-17 | 2008-10-15 | F.Hoffmann-La Roche Ag | Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine useful for the treatment of alzheimer's disease via gaba receptors |
| EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
| DE602007006010D1 (de) * | 2006-05-31 | 2010-06-02 | Galapagos Nv | Triazolopyrazinverbindungen zur behandlung von degenerations- und entzündungskrankheiten |
| WO2008016648A2 (en) * | 2006-08-01 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions and methods |
| US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| EA017925B1 (ru) * | 2006-08-02 | 2013-04-30 | Цитокинетикс, Инкорпорэйтед | ПРОИЗВОДНЫЕ 1Н-ИМИДАЗО[4,5-b]ПИРАЗИНА |
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| EP1974729A1 (en) * | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
| US7851484B2 (en) * | 2007-03-30 | 2010-12-14 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| GB0708188D0 (en) * | 2007-04-27 | 2007-06-06 | Merck Sharp & Dohme | Therapeutic compounds |
| BRPI0911659B8 (pt) * | 2008-04-15 | 2021-05-25 | Eisai R&D Man Co Ltd | composto 3-fenilpirazolo[5,1-b]tiazol e composição farmacêutica compreendendo o mesmo |
| AU2009268406A1 (en) * | 2008-07-10 | 2010-01-14 | Southern Research Institute | 5-Quinolinone and Imidazopyridine compounds and use thereof |
| WO2010032195A1 (en) * | 2008-09-16 | 2010-03-25 | Csir | Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors |
| SG10202007719TA (en) | 2008-12-05 | 2020-09-29 | Takeda Vaccines Inc | Compositions, methods and uses for inducing viral growth |
| AR078521A1 (es) * | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
| KR101951220B1 (ko) | 2011-07-13 | 2019-02-22 | 싸이토키네틱스, 인코포레이티드 | 조합 als 치료법 |
| RU2015118985A (ru) | 2012-11-14 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Производные имидазопиридина |
| AU2014231009B2 (en) * | 2013-03-14 | 2017-10-05 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| US10653681B2 (en) | 2016-03-16 | 2020-05-19 | Recurium Ip Holdings, Llc | Analgesic compounds |
| AU2018258588B2 (en) * | 2017-04-28 | 2022-06-02 | Dana-Farber Cancer Institute, Inc. | Inhibitors of TRIM33 and methods of use |
| WO2019070943A1 (en) * | 2017-10-04 | 2019-04-11 | Dana-Farber Cancer Institute, Inc. | SMALL MOLECULE INHIBITION OF SALL4 TRANSCRIPTION FACTOR AND USES THEREOF |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3269604D1 (en) | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| EP0266890A1 (en) * | 1986-10-07 | 1988-05-11 | Yamanouchi Pharmaceutical Co. Ltd. | Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them |
| RU2043716C1 (ru) * | 1989-06-23 | 1995-09-20 | Такеда Кемикал Индастриз Лтд. | Амидное производное и фунгицидный состав на его основе |
| NZ238863A (en) * | 1990-07-19 | 1993-03-26 | Janssen Pharmaceutica Nv | Substituted thiazolyl and pyridinyl derivatives |
| TW274551B (es) * | 1991-04-16 | 1996-04-21 | Takeda Pharm Industry Co Ltd | |
| DE4327027A1 (de) * | 1993-02-15 | 1994-08-18 | Bayer Ag | Imidazoazine |
| WO1996033195A1 (fr) * | 1995-04-21 | 1996-10-24 | Shinnippon Pharmaceutical Inc. | IMIDAZO[1,2-a]PYRIDINES DE FUSION |
| AU2001270297A1 (en) * | 2000-06-30 | 2002-01-14 | Neurogen Corporation | 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands |
-
2000
- 2000-09-18 EP EP00967692A patent/EP1218382B1/de not_active Expired - Lifetime
- 2000-09-18 JP JP2001530329A patent/JP2003511451A/ja not_active Withdrawn
- 2000-09-18 CN CNB008159866A patent/CN1257169C/zh not_active Expired - Fee Related
- 2000-09-18 PL PL00355206A patent/PL355206A1/xx not_active IP Right Cessation
- 2000-09-18 NZ NZ518390A patent/NZ518390A/en unknown
- 2000-09-18 PT PT00967692T patent/PT1218382E/pt unknown
- 2000-09-18 AT AT00967692T patent/ATE258554T1/de active
- 2000-09-18 SK SK436-2002A patent/SK286788B6/sk not_active IP Right Cessation
- 2000-09-18 WO PCT/EP2000/009096 patent/WO2001027111A2/de active IP Right Grant
- 2000-09-18 RU RU2002110102/04A patent/RU2264402C2/ru not_active IP Right Cessation
- 2000-09-18 NZ NZ518439A patent/NZ518439A/en unknown
- 2000-09-18 HU HU0203052A patent/HUP0203052A3/hu unknown
- 2000-09-18 ES ES00967692T patent/ES2213611T3/es not_active Expired - Lifetime
- 2000-09-18 KR KR1020027004516A patent/KR100756592B1/ko not_active Expired - Fee Related
- 2000-09-18 CZ CZ20021210A patent/CZ20021210A3/cs unknown
- 2000-09-18 DE DE50005155T patent/DE50005155D1/de not_active Expired - Lifetime
- 2000-09-18 CA CA002382919A patent/CA2382919C/en not_active Expired - Fee Related
- 2000-09-18 DK DK00967692T patent/DK1218382T3/da active
- 2000-09-18 BR BR0014818-0A patent/BR0014818A/pt not_active Application Discontinuation
- 2000-09-18 AU AU77771/00A patent/AU779197B2/en not_active Ceased
- 2000-10-05 AR ARP000105254A patent/AR025962A1/es unknown
- 2000-10-05 CO CO00075814A patent/CO5251378A1/es not_active Application Discontinuation
- 2000-10-05 UY UY26372A patent/UY26372A1/es not_active Application Discontinuation
- 2000-10-06 PE PE2000001064A patent/PE20010634A1/es not_active Application Discontinuation
-
2002
- 2002-04-03 NO NO20021565A patent/NO322754B1/no not_active IP Right Cessation
- 2002-04-08 US US10/117,333 patent/US6638933B2/en not_active Expired - Fee Related
- 2002-12-28 HK HK02109382.5A patent/HK1047747B/zh not_active IP Right Cessation
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| FC | Refusal |