PE20001641A1 - Ligandos de receptores de melanocortina - Google Patents
Ligandos de receptores de melanocortinaInfo
- Publication number
- PE20001641A1 PE20001641A1 PE2000000267A PE0002672000A PE20001641A1 PE 20001641 A1 PE20001641 A1 PE 20001641A1 PE 2000000267 A PE2000000267 A PE 2000000267A PE 0002672000 A PE0002672000 A PE 0002672000A PE 20001641 A1 PE20001641 A1 PE 20001641A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alkine
- halo
- melanocurtain
- acilo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
- C07K14/685—Alpha-melanotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pregnancy & Childbirth (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
Abstract
SE REFIERE A UN PEPTIDO CICLICO DE FORMULA I, DONDE: m, n, q SON 0-4; p ES 0-5; X ES H, HALO, N(R8)SO2R8", SO2R8", SO2-NR8R8`, (CH2)r-PO2HR14, DIFERENTES A E, -(CH2)-m; r ES 0-10; R14 ES OH, H, ALQUILO, ENTRE OTROS; R8 Y R8' SON H, ALQUILO, ACILO, ENTRE OTROS; R8" ES H, ALQUILO, HETEROALQUILO, ENTRE OTROS; O DOS MITADES DE X PUEDE FORMAR ENTRE SI UN ANILLO CONDENSADO CON FENILO; E ES H, HALO, NR13R13', NR13SO2R13", (CH2)rPO2HR15; R15 ES OH, H, ALQUILO, ENTRE OTROS; CUANDO X ES H, E NO ES H, R13 Y R13' SON H, ALQUILO, ACILO, ENTRE OTROS, R13" ES H, ALQUILO, HETEROALQUILO, ENTRE OTROS; Z ES H, OH, HALO, TIOL, OR9, NR9R9', ENTRE OTROS; R9 Y R9' SON H, ALQUILO, ACILO, ENTRE OTROS; DE SNR2C(=NR3)NR4R5, IMIDAZOL, NR4R5; R2 Y R3 SON H, ALQUILO, ALQUENO, ALQUINO O R2 Y R3 O R2 Y R4 O R3 Y R4 O R4 Y R5 JUNTOS SE UNEN PARA FORMAR UN HETEROCICLOALQUILO, HETEROARILO; O R4 Y R5 SON H, ALQUILO, ALQUENO, ALQUINO; R1 Y R1' SON H ALQUILO, ARILO, HETEROARILO, ENTRE OTROS; G ES UN ARILO BICICLICO, HETEROARILOBICICLICO; R11 ES H, ALQUILO, ALQUENO, ARILO, ENTRE OTROS; W ES CH2, CO; M' ES N, CH; B SE ENLAZA A M' Y W Y FORMA UN ANILLO. LOS ANALOGOS DE PEPTIDOS CICLICOS SON DE LOS RECEPTORES DE MELANOCORTINA DE PREFERENCIA PO LOS RECEPTORES MC-4, MC-3
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12667399P | 1999-03-29 | 1999-03-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20001641A1 true PE20001641A1 (es) | 2001-02-07 |
Family
ID=22426131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000267A PE20001641A1 (es) | 1999-03-29 | 2000-03-29 | Ligandos de receptores de melanocortina |
Country Status (34)
Country | Link |
---|---|
US (2) | US6613874B1 (es) |
EP (1) | EP1165613B1 (es) |
JP (1) | JP2002542159A (es) |
KR (2) | KR100519201B1 (es) |
CN (1) | CN1249086C (es) |
AR (1) | AR023201A1 (es) |
AT (1) | ATE393783T1 (es) |
AU (1) | AU763510B2 (es) |
BR (1) | BR0009497A (es) |
CA (1) | CA2368431C (es) |
CO (1) | CO5170531A1 (es) |
CZ (1) | CZ20013407A3 (es) |
DE (1) | DE60038734T2 (es) |
DK (1) | DK1165613T3 (es) |
ES (1) | ES2304345T3 (es) |
HK (1) | HK1044954B (es) |
HU (1) | HUP0202203A3 (es) |
ID (1) | ID30262A (es) |
IL (1) | IL145406A0 (es) |
MA (1) | MA25403A1 (es) |
MX (1) | MXPA01009881A (es) |
MY (1) | MY126585A (es) |
NO (1) | NO20014568L (es) |
NZ (1) | NZ514141A (es) |
PE (1) | PE20001641A1 (es) |
PL (1) | PL350095A1 (es) |
PT (1) | PT1165613E (es) |
RU (1) | RU2213098C2 (es) |
SA (1) | SA00210192B1 (es) |
SK (1) | SK13082001A3 (es) |
TR (1) | TR200102765T2 (es) |
TW (1) | TWI250990B (es) |
WO (1) | WO2000058361A1 (es) |
ZA (1) | ZA200107411B (es) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002064091A2 (en) | 2001-02-13 | 2002-08-22 | Palatin Technologies, Inc. | Melanocortin metallopeptides for treatment of sexual dysfunction |
US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
JP2003505435A (ja) | 1999-06-04 | 2003-02-12 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン−4受容体ゴニストとしての置換ピペリジン |
US7235625B2 (en) | 1999-06-29 | 2007-06-26 | Palatin Technologies, Inc. | Multiple agent therapy for sexual dysfunction |
WO2001052880A1 (en) * | 2000-01-18 | 2001-07-26 | Merck & Co., Inc. | Cyclic peptides as potent and selective melanocortin-4 receptor antagonists |
AU8402601A (en) | 2000-08-30 | 2002-03-13 | Hoffmann La Roche | Selective cyclic peptides |
CA2420045A1 (en) * | 2000-09-27 | 2002-04-04 | The Procter & Gamble Company | Melanocortin receptor ligands |
US7345144B2 (en) * | 2001-07-11 | 2008-03-18 | Palatin Technologies, Inc. | Cyclic peptides for treatment of cachexia |
US7342089B2 (en) * | 2001-07-11 | 2008-03-11 | Palatin Technologies, Inc. | Cyclic peptides for treatment for cachexia |
CA2453515A1 (en) | 2001-07-11 | 2003-01-23 | Palatin Technologies, Inc. | Linear and cyclic melanocortin receptor-specific peptides |
US20030195187A1 (en) * | 2002-02-04 | 2003-10-16 | Chiron Corporation | Guanidino compounds |
US7034004B2 (en) * | 2002-05-07 | 2006-04-25 | University Of Florida | Peptides and methods for the control of obesity |
US7323462B2 (en) | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
EP1644022A1 (en) * | 2003-06-19 | 2006-04-12 | Eli Lilly And Company | Uses of melanocortin-3 receptor (mc3r) agonist peptides |
KR20060014444A (ko) * | 2003-06-19 | 2006-02-15 | 일라이 릴리 앤드 캄파니 | 멜라노코르틴 수용체 4 (mc4) 작용제 및 그의 용도 |
CN101497654A (zh) * | 2003-09-30 | 2009-08-05 | 诺沃挪第克公司 | 黑皮素受体激动剂 |
AU2015201062B2 (en) * | 2003-11-05 | 2017-03-09 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides and uses thereof |
ES2586387T3 (es) * | 2003-11-05 | 2016-10-14 | Dana-Farber Cancer Institute, Inc. | Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular |
BRPI0506864A (pt) | 2004-01-21 | 2007-05-29 | Novo Nordisk As | método para conjugar peptìdeos, peptìdeo conjugado, composto e sais, pró-drogas e solvatos farmaceuticamente aceitáveis destes, composição farmacêutica, uso de um composto, e, método para tratamento de doença |
US6974187B2 (en) * | 2004-01-28 | 2005-12-13 | Tachi-S Co., Ltd. | Vehicle seat structure |
US20070123453A1 (en) * | 2004-03-29 | 2007-05-31 | Heiman Mark L | Uses of melanocortin-4 receptor (mc4r) agonist peptides administered by continuous infusion |
WO2006041769A2 (en) * | 2004-10-05 | 2006-04-20 | Merck & Co., Inc. | Methods for the treatment of substance abuse and addiction |
WO2006060873A1 (en) * | 2004-12-09 | 2006-06-15 | Prince Henry's Institute Of Medical Research | Method for restoring reproductive function |
WO2006073772A1 (en) * | 2005-01-05 | 2006-07-13 | Eli Lilly And Company | Polyethylene glycol linked mc4r or mc3r agonist peptides |
WO2006073771A2 (en) * | 2005-01-05 | 2006-07-13 | Eli Lilly And Company | Polyethylene glycol linked mc4r or mc3r agonist peptides |
US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
US7754691B1 (en) | 2005-07-07 | 2010-07-13 | Palatin Technologies, Inc. | Linear melanocortin receptor-specific peptides for cachexia |
CN119119190A (zh) | 2005-07-08 | 2024-12-13 | 益普生制药股份有限公司 | 黑皮质素受体配体 |
CN101528250A (zh) * | 2005-07-08 | 2009-09-09 | 研究及应用科学协会股份有限公司 | 黑皮质素受体的配体 |
WO2007077112A1 (en) * | 2005-12-30 | 2007-07-12 | F. Hoffmann-La Roche Ag | Methods for the synthesis of arginine-containing peptides |
AU2007255366B2 (en) | 2006-06-09 | 2013-07-18 | Synact Pharma Aps | Phenyl pyrrole aminoguanidine derivatives |
US7981998B2 (en) | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
US7960506B2 (en) | 2006-12-14 | 2011-06-14 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
EP2952522B1 (en) | 2007-01-31 | 2019-10-30 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
EP2564862B1 (en) | 2007-02-23 | 2017-08-02 | Aileron Therapeutics, Inc. | Substituted amino acids for preparing triazole linked macrocyclic peptides |
BRPI0809366B8 (pt) | 2007-03-28 | 2021-05-25 | Harvard College | polipeptídeo substancialmente alfa-helicoidal, método para fabricação do mesmo, aminoácido e composição farmacêutica |
CA2689016C (en) | 2007-05-25 | 2014-08-12 | Ipsen Pharma S.A.S. | Melanocortin receptor ligands modified with hydantoin |
WO2009099677A2 (en) * | 2008-02-08 | 2009-08-13 | Aileron Therapeutics, Inc. | Therapeutic peptidomimetic macrocycles |
WO2009126292A2 (en) * | 2008-04-08 | 2009-10-15 | Aileron Therapeutics, Inc. | Biologically active peptidomimetic macrocycles |
US20110144303A1 (en) * | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
EP2300036B1 (en) | 2008-06-09 | 2017-04-05 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptides for treatment of sexual dysfunction |
US20090305960A1 (en) * | 2008-06-09 | 2009-12-10 | Palatin Technologies, Inc | Melanocortin Receptor-Specific Peptides for Treatment of Obesity / 669 |
EP2356139A4 (en) * | 2008-07-23 | 2013-01-09 | Harvard College | LIGURE COMBINED POLYPEPTIDES |
CN104961795A (zh) | 2008-09-22 | 2015-10-07 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
CN102256615A (zh) | 2009-01-14 | 2011-11-23 | 爱勒让治疗公司 | 拟肽大环化合物 |
UY32690A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Péptidos específicos para receptores de melanocortina |
WO2010144344A2 (en) | 2009-06-08 | 2010-12-16 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptides |
WO2010144341A2 (en) | 2009-06-08 | 2010-12-16 | Palatin Technologies, Inc. | Lactam-bridged melanocortin receptor-specific peptides |
EP2453908B1 (en) | 2009-07-13 | 2018-03-14 | President and Fellows of Harvard College | Bifunctional stapled polypeptides and uses thereof |
US20130072439A1 (en) | 2009-09-22 | 2013-03-21 | Huw M. Nash | Peptidomimetic macrocycles |
RU2012125033A (ru) * | 2009-11-16 | 2014-01-20 | Ипсен Фарма С.А.С. | СПОСОБ СИНТЕЗА Ас-Arg-ЦИКЛО(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2 |
CA2781402C (en) | 2009-11-23 | 2017-03-21 | Palatin Technologies, Inc. | Melanocortin-1 receptor-specific cyclic peptides |
CN102712674A (zh) | 2009-11-23 | 2012-10-03 | 帕拉丁科技公司 | 黑皮质素-1受体-特异性的线性肽 |
CN101824415A (zh) * | 2010-03-31 | 2010-09-08 | 华东师范大学 | 黑素皮质1型受体基因的snp及其应用 |
WO2012021876A2 (en) | 2010-08-13 | 2012-02-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
US8957026B2 (en) | 2010-09-22 | 2015-02-17 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
CA2825098C (en) | 2011-01-27 | 2020-03-10 | Universite De Montreal | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators |
WO2012174423A1 (en) | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Stabilized polypeptides as regulators of rab gtpase function |
JP6342808B2 (ja) | 2011-10-18 | 2018-06-13 | エイルロン セラピューティクス,インコーポレイテッド | ペプチドミメティック大環状化合物 |
AU2013221433B2 (en) | 2012-02-15 | 2018-01-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
RU2642299C2 (ru) | 2012-02-15 | 2018-01-24 | Эйлерон Терапьютикс, Инк. | P53 пептидомиметические макроциклы |
CA2925035C (en) | 2012-09-26 | 2021-05-25 | President And Fellows Of Harvard College | Proline-locked stapled peptides and uses thereof |
BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
KR102637496B1 (ko) | 2013-03-13 | 2024-02-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스테이플드 및 스티치드 폴리펩티드 및 그의 용도 |
AU2014278005B2 (en) | 2013-06-14 | 2018-11-22 | President And Fellows Of Harvard College | Stabilized polypeptide insulin receptor modulators |
EP3145523A4 (en) | 2014-05-21 | 2018-02-21 | President and Fellows of Harvard College | Ras inhibitory peptides and uses thereof |
MX2017003797A (es) | 2014-09-24 | 2017-06-15 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
CN112972378A (zh) | 2014-09-24 | 2021-06-18 | 艾瑞朗医疗公司 | 拟肽大环化合物及其制剂 |
BR112017019738A2 (pt) | 2015-03-20 | 2018-05-29 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
WO2017044633A1 (en) | 2015-09-10 | 2017-03-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
CN110681362B (zh) * | 2019-09-26 | 2020-09-11 | 浙江大学 | 以羧基和吲哚基为功能基团的混合模式层析介质 |
US11590209B2 (en) | 2020-01-21 | 2023-02-28 | Palatin Technologies, Inc. | Use of bremelanotide in patients with controlled hypertension |
US11932628B2 (en) | 2021-01-04 | 2024-03-19 | Regents Of The University Of Minnesota | Selective small molecule peptidomimetic melanocortin ligands |
KR20240024818A (ko) | 2021-06-21 | 2024-02-26 | 신액트 파마 에이피에스 | 페닐 피롤 아미노구아니딘 염 및 제형 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5462927A (en) | 1985-04-30 | 1995-10-31 | The Administrators Of The Tulane Educational Fund | Peptides aiding nerve regeneration |
DE3851002T2 (de) | 1987-05-22 | 1995-02-02 | University Patents, Inc., Westport, Conn. | Lineare und zyklische Analoge von alpha-MSH-Fragmenten mit ausserordentlicher Wirkung. |
WO1989002897A1 (en) | 1987-09-24 | 1989-04-06 | The Administrators Of The Tulane Educational Fund | Therapeutic peptides |
ZA908610B (en) | 1989-11-03 | 1991-08-28 | Univ Tulane | Peptides aiding nerve regeneration |
ATE140236T1 (de) | 1991-02-15 | 1996-07-15 | Takeda Chemical Industries Ltd | Endothelin antagoniste |
ATE155486T1 (de) | 1991-08-13 | 1997-08-15 | Takeda Chemical Industries Ltd | Zyklische peptide und ihre verwendung |
RU2096415C1 (ru) * | 1991-09-30 | 1997-11-20 | Дзе Дюпон Мерк Фармасьютикал Компани | Циклические пептиды или их фармацевтически приемлемые соли, фармацевтическая композиция |
EP0552417B1 (en) | 1991-11-19 | 1999-07-07 | Takeda Chemical Industries, Ltd. | Cyclic peptides and use thereof |
EP0547317A1 (en) | 1991-12-19 | 1993-06-23 | Takeda Chemical Industries, Ltd. | Endothelin antagonists |
DE9203901U1 (de) | 1992-03-24 | 1992-07-16 | Croon & Lucke Maschinenfabrik Gmbh, 7947 Mengen | Gestell zum Lagern von flächigen Werkstücken |
US5569741A (en) | 1992-07-27 | 1996-10-29 | Biomeasure, Inc. | Cyclic octapeptide neuromedin B receptor antagonists |
CA2118588A1 (en) | 1992-07-27 | 1994-02-03 | David H. Coy | Neuromedin b receptor antagonists |
AU673731B2 (en) | 1993-06-03 | 1996-11-21 | Banyu Pharmaceutical Co., Ltd. | Novel endothelin antagonistic peptide |
EP0714909A1 (en) | 1994-12-01 | 1996-06-05 | Takeda Chemical Industries, Ltd. | Composition for prophylaxis or treatment of pulmonary circulatory diseases |
US6054556A (en) * | 1995-04-10 | 2000-04-25 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Melanocortin receptor antagonists and agonists |
US5731408A (en) * | 1995-04-10 | 1998-03-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Peptides having potent antagonist and agonist bioactivities at melanocortin receptors |
AU5514396A (en) | 1995-04-28 | 1996-11-18 | Takeda Chemical Industries Ltd. | Cyclic pentapeptide lh-rh receptor antagonists |
US5817750A (en) | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
US6362164B1 (en) | 1996-06-11 | 2002-03-26 | Novartis Ag | Combination of a somatostatin analogue and a rapamycin |
CA2258487A1 (en) | 1996-06-25 | 1997-12-31 | Nisshin Flour Milling Co., Ltd. | Cyclic depsipeptides and drugs containing the same as the active ingredient |
EP0815870A3 (en) | 1996-06-27 | 2000-05-03 | Takeda Chemical Industries, Ltd. | Composition for prohylaxis or treatment of cerebral infarction |
US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
IT1288388B1 (it) | 1996-11-19 | 1998-09-22 | Angeletti P Ist Richerche Bio | Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia |
AU5348098A (en) | 1996-12-17 | 1998-07-15 | Quadrant Holdings Cambridge Limited | Melanocortins |
SE9700620D0 (sv) * | 1997-02-21 | 1997-02-21 | Wapharm Ab | Cykliska peptider med selektivitet för MSH-receptor subtyper |
GB9827500D0 (en) | 1998-12-14 | 1999-02-10 | Wapharm Ab | Compounds for control of eating, growth and body weight |
-
2000
- 2000-03-21 MX MXPA01009881A patent/MXPA01009881A/es active IP Right Grant
- 2000-03-21 KR KR10-2001-7012436A patent/KR100519201B1/ko not_active Expired - Fee Related
- 2000-03-21 IL IL14540600A patent/IL145406A0/xx unknown
- 2000-03-21 ES ES00919500T patent/ES2304345T3/es not_active Expired - Lifetime
- 2000-03-21 AU AU40179/00A patent/AU763510B2/en not_active Ceased
- 2000-03-21 PL PL00350095A patent/PL350095A1/xx not_active Application Discontinuation
- 2000-03-21 CA CA002368431A patent/CA2368431C/en not_active Expired - Fee Related
- 2000-03-21 HU HU0202203A patent/HUP0202203A3/hu unknown
- 2000-03-21 BR BR0009497-8A patent/BR0009497A/pt not_active IP Right Cessation
- 2000-03-21 EP EP00919500A patent/EP1165613B1/en not_active Expired - Lifetime
- 2000-03-21 NZ NZ514141A patent/NZ514141A/xx unknown
- 2000-03-21 DE DE60038734T patent/DE60038734T2/de not_active Expired - Fee Related
- 2000-03-21 RU RU2001128890/04A patent/RU2213098C2/ru not_active IP Right Cessation
- 2000-03-21 TR TR2001/02765T patent/TR200102765T2/xx unknown
- 2000-03-21 KR KR1020047019303A patent/KR100558131B1/ko not_active Expired - Fee Related
- 2000-03-21 ID IDW00200102111A patent/ID30262A/id unknown
- 2000-03-21 PT PT00919500T patent/PT1165613E/pt unknown
- 2000-03-21 SK SK1308-2001A patent/SK13082001A3/sk unknown
- 2000-03-21 CZ CZ20013407A patent/CZ20013407A3/cs unknown
- 2000-03-21 WO PCT/US2000/007473 patent/WO2000058361A1/en not_active Application Discontinuation
- 2000-03-21 DK DK00919500T patent/DK1165613T3/da active
- 2000-03-21 AT AT00919500T patent/ATE393783T1/de not_active IP Right Cessation
- 2000-03-21 JP JP2000608653A patent/JP2002542159A/ja active Pending
- 2000-03-21 CN CNB008057540A patent/CN1249086C/zh not_active Expired - Fee Related
- 2000-03-27 MY MYPI20001220A patent/MY126585A/en unknown
- 2000-03-28 CO CO00022068A patent/CO5170531A1/es not_active Application Discontinuation
- 2000-03-28 TW TW089105726A patent/TWI250990B/zh not_active IP Right Cessation
- 2000-03-29 US US09/537,789 patent/US6613874B1/en not_active Expired - Fee Related
- 2000-03-29 AR ARP000101405A patent/AR023201A1/es active IP Right Grant
- 2000-03-29 PE PE2000000267A patent/PE20001641A1/es not_active Application Discontinuation
- 2000-06-26 SA SA00210192A patent/SA00210192B1/ar unknown
-
2001
- 2001-09-07 ZA ZA200107411A patent/ZA200107411B/xx unknown
- 2001-09-20 NO NO20014568A patent/NO20014568L/no not_active Application Discontinuation
- 2001-09-26 MA MA26340A patent/MA25403A1/fr unknown
-
2002
- 2002-06-24 HK HK02104687.8A patent/HK1044954B/zh not_active IP Right Cessation
-
2003
- 2003-07-02 US US10/612,104 patent/US6951916B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20001641A1 (es) | Ligandos de receptores de melanocortina | |
PE20021087A1 (es) | Ligandos receptores de melanocortina | |
DE60135764D1 (de) | Stickstoffhaltige, fünfgliedrige ringverbindungen | |
PT1299409E (pt) | Compostos organicos | |
ATE299499T1 (de) | Gastrin und cholecystokinin rezeptor ligande | |
CO5280060A1 (es) | Aminoacidos biciclicos como agentes farmaceuticos | |
SE9301911D0 (sv) | New peptide derivatives | |
MEP61208A (en) | Novel compounds having inhibitory activity against sodium-dependant transporter | |
EA200300428A1 (ru) | Антагонисты метаботропных рецепторов глутамата | |
ATE268806T1 (de) | Lichtemittierende dendrimere | |
DK1260512T3 (da) | Hidtil ukendte, cykliske amidderivater | |
EA199800051A1 (ru) | Производные бензамида и их применение в качестве антагонистов вазопрессина | |
PE20021094A1 (es) | Derivados de ciclohexano-1,4-diamina sustituidos | |
DE69740158D1 (de) | Verbindungen die die aktivität von calcium-rezeptoren beeinflussen | |
PE20020406A1 (es) | 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6-DISUSTITUIDAS COMO INHIBIDORES DE LAS PROTEINAS CINASAS | |
EP1468990A4 (en) | PIPERAZINE DERIVATIVE | |
EA200200731A1 (ru) | Производные фенилпиперазинила | |
ATE352555T1 (de) | Perindopril | |
DK1078928T3 (da) | Pyridinderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse | |
DE50311208D1 (de) | Verfahren zur Herstellung von Polyhalogenalkylaryl-Verbindungen | |
DE60136476D1 (de) | -stickstoffhaltigen zyklischen polyaminen und deren verbindungen | |
PE20021046A1 (es) | Sulfonilguanidina que tiene afinidad al punto de fijacion de gabapentina | |
UA41300C2 (uk) | Аналоги гормонів-антагоністів lhrh і спосіб їх отримання | |
ATE198599T1 (de) | Guanidinium-verbindungen, pharmazeutische präparate davon und ihre verwendungen | |
EA200200807A1 (ru) | Аминокислотные соединения и их применение в качестве ингибиторов nep, ace и ece |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |