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PE20001641A1 - Ligandos de receptores de melanocortina - Google Patents

Ligandos de receptores de melanocortina

Info

Publication number
PE20001641A1
PE20001641A1 PE2000000267A PE0002672000A PE20001641A1 PE 20001641 A1 PE20001641 A1 PE 20001641A1 PE 2000000267 A PE2000000267 A PE 2000000267A PE 0002672000 A PE0002672000 A PE 0002672000A PE 20001641 A1 PE20001641 A1 PE 20001641A1
Authority
PE
Peru
Prior art keywords
alkyl
alkine
halo
melanocurtain
acilo
Prior art date
Application number
PE2000000267A
Other languages
English (en)
Inventor
Feng Wang
Frank Hallock Ebetino
Russell James Sheldon
Adam Wieslaw Mazur
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20001641A1 publication Critical patent/PE20001641A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68Melanocyte-stimulating hormone [MSH]
    • C07K14/685Alpha-melanotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68Melanocyte-stimulating hormone [MSH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)

Abstract

SE REFIERE A UN PEPTIDO CICLICO DE FORMULA I, DONDE: m, n, q SON 0-4; p ES 0-5; X ES H, HALO, N(R8)SO2R8", SO2R8", SO2-NR8R8`, (CH2)r-PO2HR14, DIFERENTES A E, -(CH2)-m; r ES 0-10; R14 ES OH, H, ALQUILO, ENTRE OTROS; R8 Y R8' SON H, ALQUILO, ACILO, ENTRE OTROS; R8" ES H, ALQUILO, HETEROALQUILO, ENTRE OTROS; O DOS MITADES DE X PUEDE FORMAR ENTRE SI UN ANILLO CONDENSADO CON FENILO; E ES H, HALO, NR13R13', NR13SO2R13", (CH2)rPO2HR15; R15 ES OH, H, ALQUILO, ENTRE OTROS; CUANDO X ES H, E NO ES H, R13 Y R13' SON H, ALQUILO, ACILO, ENTRE OTROS, R13" ES H, ALQUILO, HETEROALQUILO, ENTRE OTROS; Z ES H, OH, HALO, TIOL, OR9, NR9R9', ENTRE OTROS; R9 Y R9' SON H, ALQUILO, ACILO, ENTRE OTROS; DE SNR2C(=NR3)NR4R5, IMIDAZOL, NR4R5; R2 Y R3 SON H, ALQUILO, ALQUENO, ALQUINO O R2 Y R3 O R2 Y R4 O R3 Y R4 O R4 Y R5 JUNTOS SE UNEN PARA FORMAR UN HETEROCICLOALQUILO, HETEROARILO; O R4 Y R5 SON H, ALQUILO, ALQUENO, ALQUINO; R1 Y R1' SON H ALQUILO, ARILO, HETEROARILO, ENTRE OTROS; G ES UN ARILO BICICLICO, HETEROARILOBICICLICO; R11 ES H, ALQUILO, ALQUENO, ARILO, ENTRE OTROS; W ES CH2, CO; M' ES N, CH; B SE ENLAZA A M' Y W Y FORMA UN ANILLO. LOS ANALOGOS DE PEPTIDOS CICLICOS SON DE LOS RECEPTORES DE MELANOCORTINA DE PREFERENCIA PO LOS RECEPTORES MC-4, MC-3
PE2000000267A 1999-03-29 2000-03-29 Ligandos de receptores de melanocortina PE20001641A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12667399P 1999-03-29 1999-03-29

Publications (1)

Publication Number Publication Date
PE20001641A1 true PE20001641A1 (es) 2001-02-07

Family

ID=22426131

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000267A PE20001641A1 (es) 1999-03-29 2000-03-29 Ligandos de receptores de melanocortina

Country Status (34)

Country Link
US (2) US6613874B1 (es)
EP (1) EP1165613B1 (es)
JP (1) JP2002542159A (es)
KR (2) KR100519201B1 (es)
CN (1) CN1249086C (es)
AR (1) AR023201A1 (es)
AT (1) ATE393783T1 (es)
AU (1) AU763510B2 (es)
BR (1) BR0009497A (es)
CA (1) CA2368431C (es)
CO (1) CO5170531A1 (es)
CZ (1) CZ20013407A3 (es)
DE (1) DE60038734T2 (es)
DK (1) DK1165613T3 (es)
ES (1) ES2304345T3 (es)
HK (1) HK1044954B (es)
HU (1) HUP0202203A3 (es)
ID (1) ID30262A (es)
IL (1) IL145406A0 (es)
MA (1) MA25403A1 (es)
MX (1) MXPA01009881A (es)
MY (1) MY126585A (es)
NO (1) NO20014568L (es)
NZ (1) NZ514141A (es)
PE (1) PE20001641A1 (es)
PL (1) PL350095A1 (es)
PT (1) PT1165613E (es)
RU (1) RU2213098C2 (es)
SA (1) SA00210192B1 (es)
SK (1) SK13082001A3 (es)
TR (1) TR200102765T2 (es)
TW (1) TWI250990B (es)
WO (1) WO2000058361A1 (es)
ZA (1) ZA200107411B (es)

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KR20020008143A (ko) 2002-01-29
WO2000058361A1 (en) 2000-10-05
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IL145406A0 (en) 2002-06-30
EP1165613A1 (en) 2002-01-02
CA2368431A1 (en) 2000-10-05
MY126585A (en) 2006-10-31
HUP0202203A3 (en) 2003-09-29
TR200102765T2 (tr) 2002-05-21
TWI250990B (en) 2006-03-11
US6951916B2 (en) 2005-10-04
DE60038734T2 (de) 2009-07-02
ATE393783T1 (de) 2008-05-15
JP2002542159A (ja) 2002-12-10
KR20050009722A (ko) 2005-01-25
KR100558131B1 (ko) 2006-03-10
BR0009497A (pt) 2002-01-15
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DK1165613T3 (da) 2008-08-25
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MA25403A1 (fr) 2002-04-01
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AU4017900A (en) 2000-10-16
US20040023859A1 (en) 2004-02-05
CA2368431C (en) 2006-01-24
RU2213098C2 (ru) 2003-09-27
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ZA200107411B (en) 2002-05-29
ID30262A (id) 2001-11-15
CO5170531A1 (es) 2002-06-27
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AU763510B2 (en) 2003-07-24
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EP1165613B1 (en) 2008-04-30
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