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PE20001565A1 - Inhibidores de metaloproteasa conteniendo alquenil y alquinil - Google Patents

Inhibidores de metaloproteasa conteniendo alquenil y alquinil

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Publication number
PE20001565A1
PE20001565A1 PE2000000232A PE0002322000A PE20001565A1 PE 20001565 A1 PE20001565 A1 PE 20001565A1 PE 2000000232 A PE2000000232 A PE 2000000232A PE 0002322000 A PE0002322000 A PE 0002322000A PE 20001565 A1 PE20001565 A1 PE 20001565A1
Authority
PE
Peru
Prior art keywords
alkyl
alkenyl
alkinyl
compound
containing alkenyl
Prior art date
Application number
PE2000000232A
Other languages
English (en)
Inventor
Biswanath De
Michael George Natchus
Neil Gregory Almstead
Stanislaw Pikul
Menyan Cheng
Roger Gunnard Bookland
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20001565A1 publication Critical patent/PE20001565A1/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P19/00—Drugs for skeletal disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE X ES OH, NHOH; W ES S,O,N(R33), (R33)C=C(R33`), N=C(R33),N=N; R33 Y R33' SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R1 ES CR6R6 R34 DONDE ES 0-4; R6 Y R6' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; R34 ES H, OH, ALCOXI, ALQUILO, ENTRE OTROS; R2 ES -(CR7R7')m-R35 DONDE m ES 0-4; R7 Y R7' SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R35 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; R3 ES (CR8R8')n-R9; n ES 0-4; R8 Y R8' SON H, ALQUILO, ALQUENILO, ALQUINILO, ARILO, ENTRE OTROS; R4 ES (CR10R10')z-A'-(CR10''R10''')o-R11, A' ES O, S, SO2; z Y o SON 0-4; R10, R10', R10'', R10''' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; R11 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; R5 Y R5' SON H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; k ES 0-4; A ES (R12)C=C(R12'), C­C; R12 Y R12' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; G ES H, (CR14R14')p-R15, ENTRE OTROS; p ES 0-4; R14 Y R14' SON H, ALQUILO, ALQUENILO, ENTRE OTROS; Z ES CICLOALQUILO, HETEROCICLOALQUILO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES ACIDO 2-{[4'-FLUORO-(1,1'-BIFENIL)-4-IL]-SULFONIL}-AMINO-5-FENILPEN-4-TINOICO, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR DE METALOPROTEASAS POR LO QUE PUEDEN SER UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, CANCER, DESORDENES CARDIOVASCULARES, CUTANEOS, OCULARES
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