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PE20000356A1 - FORMA VI DE 5,6-DICLORO-2-(ISOPROPILAMINO)-1-(ß-L-RIBOFURANOSIL)-1H-BENCIMIDAZOL - Google Patents

FORMA VI DE 5,6-DICLORO-2-(ISOPROPILAMINO)-1-(ß-L-RIBOFURANOSIL)-1H-BENCIMIDAZOL

Info

Publication number
PE20000356A1
PE20000356A1 PE1999000264A PE00026499A PE20000356A1 PE 20000356 A1 PE20000356 A1 PE 20000356A1 PE 1999000264 A PE1999000264 A PE 1999000264A PE 00026499 A PE00026499 A PE 00026499A PE 20000356 A1 PE20000356 A1 PE 20000356A1
Authority
PE
Peru
Prior art keywords
ribofuranosil
isopropylamine
dichloro
benzimidazole
refers
Prior art date
Application number
PE1999000264A
Other languages
English (en)
Inventor
Barry Howard Carter
Lian-Feng Huang
Anne Hodgson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20000356A1 publication Critical patent/PE20000356A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UNA FORMA CRISTALINA VI DEL COMPUESTO ANTIVIRAL 5,6-DICLORO-2-(ISOPROPILAMINO)-1-(ß-L-RIBOFURANOSIL)-1H-BENCIMIDAZOL CONOCIDO COMO 1263 W94, CARACTERIZADA POR SU PATRON DE DIFRACCION DE RAYOS X. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE LA FORMA VI Y LA FORMA AMORFA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE LA CRISTALIZACION DE 5,6-DICLORO-2-(ISOPROPILAMINO)-1-ß-L-RIBOFURANOSIL-1H-BENCIMIDAZOL EN SOLUCION ACUOSA. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE INFECCIONES VIRALES CAUSADAS POR EL VIRUS DEL HERPES
PE1999000264A 1998-04-07 1999-04-05 FORMA VI DE 5,6-DICLORO-2-(ISOPROPILAMINO)-1-(ß-L-RIBOFURANOSIL)-1H-BENCIMIDAZOL PE20000356A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9807355.4A GB9807355D0 (en) 1998-04-07 1998-04-07 Antiviral compound

Publications (1)

Publication Number Publication Date
PE20000356A1 true PE20000356A1 (es) 2000-04-26

Family

ID=10829933

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000264A PE20000356A1 (es) 1998-04-07 1999-04-05 FORMA VI DE 5,6-DICLORO-2-(ISOPROPILAMINO)-1-(ß-L-RIBOFURANOSIL)-1H-BENCIMIDAZOL

Country Status (40)

Country Link
US (1) US6482939B1 (es)
EP (1) EP1070078B1 (es)
JP (1) JP2002510702A (es)
KR (1) KR100573635B1 (es)
CN (1) CN1222534C (es)
AP (1) AP2000001946A0 (es)
AR (1) AR014973A1 (es)
AT (1) ATE231517T1 (es)
AU (1) AU753527B2 (es)
BG (1) BG104909A (es)
BR (2) BRPI9909471B8 (es)
CA (1) CA2327495C (es)
CO (1) CO5011057A1 (es)
DE (1) DE69905025T2 (es)
DK (1) DK1070078T3 (es)
EA (1) EA002953B1 (es)
EE (1) EE04121B1 (es)
EG (1) EG24597A (es)
ES (1) ES2191429T3 (es)
GB (1) GB9807355D0 (es)
GE (1) GEP20022840B (es)
HK (1) HK1032060A1 (es)
HR (1) HRP20000670B1 (es)
HU (1) HUP0101549A3 (es)
ID (1) ID26573A (es)
IL (2) IL138559A0 (es)
IS (1) IS5634A (es)
MA (1) MA26617A1 (es)
NO (1) NO316896B1 (es)
NZ (1) NZ507012A (es)
OA (1) OA11534A (es)
PE (1) PE20000356A1 (es)
PL (1) PL194752B1 (es)
PT (1) PT1070078E (es)
SI (1) SI1070078T1 (es)
SK (1) SK283735B6 (es)
TR (1) TR200002847T2 (es)
WO (1) WO1999051617A2 (es)
YU (1) YU58600A (es)
ZA (1) ZA200005197B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
EP2265115B1 (en) * 2008-03-12 2012-11-28 Janssen Pharmaceutica, N.V. Combinations of hydroxypyrion compounds and silver compounds
US8541391B2 (en) * 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
WO2023105483A1 (en) * 2021-12-10 2023-06-15 Assembly Biosciences, Inc. Crystalline forms of a 5-aminopyrazole compound useful for treating hbv
TW202430155A (zh) 2022-10-12 2024-08-01 日商武田藥品工業股份有限公司 病毒抑制劑、其合成及其中間體
WO2024246841A2 (en) 2023-05-31 2024-12-05 Takeda Pharmaceutical Company Limited Maribavir compositions and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399987A (en) 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
AU5447094A (en) 1992-10-21 1994-05-09 Regents Of The University Of Michigan, The Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB2319961A (en) * 1996-12-07 1998-06-10 Glaxo Group Ltd Pharmaceutical composition for treatment of restenosis
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound

Also Published As

Publication number Publication date
HUP0101549A2 (hu) 2001-10-28
CN1304413A (zh) 2001-07-18
GEP20022840B (en) 2002-11-25
AR014973A1 (es) 2001-04-11
DE69905025T2 (de) 2003-10-16
BRPI9909471B1 (pt) 2018-11-21
OA11534A (en) 2004-05-06
SK283735B6 (sk) 2003-12-02
JP2002510702A (ja) 2002-04-09
HK1032060A1 (en) 2001-07-06
AU753527B2 (en) 2002-10-17
BR9909471A (pt) 2000-12-19
SI1070078T1 (en) 2003-08-31
AP2000001946A0 (en) 2000-12-31
EE200000585A (et) 2002-04-15
DK1070078T3 (da) 2003-05-19
CN1222534C (zh) 2005-10-12
US6482939B1 (en) 2002-11-19
ES2191429T3 (es) 2003-09-01
NO20005003L (no) 2000-12-06
NO20005003D0 (no) 2000-10-04
MA26617A1 (fr) 2004-12-20
GB9807355D0 (en) 1998-06-03
HRP20000670A2 (en) 2000-12-31
PT1070078E (pt) 2003-06-30
IS5634A (is) 2000-09-22
EG24597A (en) 2009-12-14
PL343712A1 (en) 2001-08-27
EP1070078B1 (en) 2003-01-22
EA200000909A1 (ru) 2001-06-25
EA002953B1 (ru) 2002-12-26
DE69905025D1 (de) 2003-02-27
BG104909A (bg) 2001-06-29
CA2327495A1 (en) 1999-10-14
HRP20000670B1 (en) 2004-04-30
EE04121B1 (et) 2003-08-15
PL194752B1 (pl) 2007-07-31
KR20010074473A (ko) 2001-08-04
YU58600A (sh) 2003-04-30
SK14822000A3 (sk) 2001-07-10
KR100573635B1 (ko) 2006-04-26
WO1999051617A2 (en) 1999-10-14
CO5011057A1 (es) 2001-02-28
HUP0101549A3 (en) 2003-07-28
BRPI9909471B8 (pt) 2021-05-25
ZA200005197B (en) 2001-09-27
IL138559A (en) 2006-12-31
WO1999051617A3 (en) 1999-12-09
ID26573A (id) 2001-01-18
EP1070078A2 (en) 2001-01-24
IL138559A0 (en) 2001-10-31
NZ507012A (en) 2003-06-30
TR200002847T2 (tr) 2001-01-22
ATE231517T1 (de) 2003-02-15
NO316896B1 (no) 2004-06-14
AU3703899A (en) 1999-10-25
CA2327495C (en) 2009-01-20

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed
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