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PE20000325A1 - Derivados de 2-ariletil-(piperidin-4-ilmetil)amina - Google Patents

Derivados de 2-ariletil-(piperidin-4-ilmetil)amina

Info

Publication number
PE20000325A1
PE20000325A1 PE1999000155A PE00015599A PE20000325A1 PE 20000325 A1 PE20000325 A1 PE 20000325A1 PE 1999000155 A PE1999000155 A PE 1999000155A PE 00015599 A PE00015599 A PE 00015599A PE 20000325 A1 PE20000325 A1 PE 20000325A1
Authority
PE
Peru
Prior art keywords
alkyl
piperidin
amine
haloalkyl
cycloalkyl
Prior art date
Application number
PE1999000155A
Other languages
English (en)
Inventor
Hans Maag
David Bruce Repke
Robin Douglas Clark
Michael Patrick Dillon
Sharathchandra Surendra Hegde
Clara Jeou Jen Lin
Iii Ralph New Harris
Joan Marie Caroon
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20000325A1 publication Critical patent/PE20000325A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA I, DONDE: R1 ES H, ALQUILO, ALQUILOXI, HALOGENO, HALOALQUILO, AMINO; R2 ES ALQUILO, ALQUILOXILO, HALOGENO, HALOALQUILO, -O(CH2)pX, -NR7R8, -NR6COR9, ENTRE OTROS; p ES 0-6; X ES HALOALQUILO, ARILO; O R1 Y R2 FORMAN UN ANILLO MONOCICLICO DE 5-6 MIEMBROS; R3 Y R4 SON ALQUILO, ALQUENILO, CICLOALQUILO; R5 ES H, -COR9, -COOR7, -CONR7R8, -CO(CH2)nCOR9, -CO(CH2)nSO2R9, -CO(CH2)nCONR7R8, -CSR9, -SO2NR6(CH2)nCOOR7, ENTRE OTROS; R6 Y R7 SON H o ALQUILO, R8 ES H, ALQUILO, CICLOALQUILO, ARILO, HETEROARILO; R9 ES ALQUILO, CICLOALQUILO, ARILALQUILO, ARILO, HETEROCICLO, HETEROARILO, ENTRE OTROS; n ES 1-6. SON COMPUESTOS PREFERIDOS N-[2-(2,3-DIHIDROBENZOFURAN-5-IL)-1-METILETIL]-N-ETIL-(1-METANSULFONIL-PIPERIDIN-4-ILMETIL)AMINA; N-[2-(2,3-DIHIDROBENZOFURAN-5-IL)-1-METILETIL]-N-PROPIL-(1-METANSULFONIL-PIPERIDIN-4-[ILMETIL]AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES ANTAGONISTA DEL RECEPTOR MUSCARINICO Y PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNOS GASTROINTESTINALES, DEL TRACTO GENITOURINARIO, DEL TRACTO RESPIRATORIO, SISTEMA CARDIOVASCULAR, SISTEMA NERVIOSO CENTRAL
PE1999000155A 1998-02-27 1999-02-23 Derivados de 2-ariletil-(piperidin-4-ilmetil)amina PE20000325A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7611398P 1998-02-27 1998-02-27
US10909798P 1998-11-19 1998-11-19

Publications (1)

Publication Number Publication Date
PE20000325A1 true PE20000325A1 (es) 2000-05-08

Family

ID=26757679

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000155A PE20000325A1 (es) 1998-02-27 1999-02-23 Derivados de 2-ariletil-(piperidin-4-ilmetil)amina

Country Status (27)

Country Link
US (1) US6319920B1 (es)
EP (1) EP1058680B1 (es)
JP (1) JP3523198B2 (es)
KR (1) KR100384906B1 (es)
CN (1) CN1143848C (es)
AR (1) AR015523A1 (es)
AT (1) ATE400554T1 (es)
AU (1) AU753255B2 (es)
BR (1) BR9909253A (es)
CA (1) CA2321198C (es)
CO (1) CO4990939A1 (es)
DE (1) DE69939053D1 (es)
ES (1) ES2310032T3 (es)
HK (1) HK1036623A1 (es)
HR (1) HRP20000544A2 (es)
HU (1) HUP0100760A3 (es)
IL (1) IL137936A0 (es)
MA (1) MA26610A1 (es)
MY (1) MY133445A (es)
NO (1) NO317106B1 (es)
NZ (1) NZ506317A (es)
PE (1) PE20000325A1 (es)
PL (1) PL194037B1 (es)
RU (1) RU2220138C2 (es)
TR (1) TR200002481T2 (es)
WO (1) WO1999043657A1 (es)
YU (1) YU53100A (es)

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Publication number Priority date Publication date Assignee Title
WO1998052944A1 (en) * 1997-05-19 1998-11-26 Sugen, Inc. Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders
KR100544000B1 (ko) 2000-05-25 2006-01-20 에프. 호프만-라 로슈 아게 치환된 1-아미노알킬-락탐 및 무스카린성 수용체길항제로서의 용도
NZ522410A (en) 2000-05-25 2004-09-24 F Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
EP1453805B1 (en) 2001-12-03 2010-12-22 F. Hoffmann-La Roche AG 4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists
DE60224221T2 (de) 2001-12-03 2008-12-11 F. Hoffmann-La Roche Ag Aminotetralinderivate, antagonisten von muscarinrezeptoren
WO2003103659A1 (ja) * 2002-06-07 2003-12-18 山之内製薬株式会社 過活動膀胱治療剤
JP2006502985A (ja) 2002-07-08 2006-01-26 ランバクシー ラボラトリーズ リミテッド ムスカリン性受容体拮抗剤として有用な３，６−二置換アザビシクロ［３．１．０］ヘキサン誘導体
TWI295669B (en) * 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
CN100364990C (zh) * 2002-10-30 2008-01-30 施万制药 取代的4-氨基-1-(吡啶甲基)哌啶和相关化合物
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
ATE368456T1 (de) * 2002-12-20 2007-08-15 Dynogen Pharmaceuticals Inc Behandlung nicht-schmerzhafter blasenstörungen mit modulatoren von alpha-2-delta- calciumkanaluntereinheiten
BRPI0408608A (pt) * 2003-03-21 2006-03-07 Dynogen Pharmaceuticals Inc uso de moduladores da subunidade (alfa)2(delta) de canal de cálcio e moduladores de músculo liso para tratamento de sintoma de um distúrbio do trato urinário inferior
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
CA2522071A1 (en) 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
US7368463B2 (en) * 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
US7214439B2 (en) * 2003-12-19 2007-05-08 Millennium Cell, Inc. Triborohydride salts as hydrogen storage materials and preparation thereof
CN101663270B (zh) 2007-04-24 2013-07-17 施万制药 可用作蕈毒碱受体拮抗剂的季铵化合物
DE102007020492A1 (de) * 2007-04-30 2008-11-06 Grünenthal GmbH Substituierte Sulfonamid-Derivate
EP3170807B1 (en) * 2015-11-23 2019-12-11 Frau Pharma S.r.l. New method for synthesis of fenfluramine
SI25272A (sl) 2016-09-23 2018-03-30 Univerza V Ljubljani Disubstituirani azetidini, pirolidini, piperidini in azepani kot zaviralci monoamin oksidaze B za zdravljenje nevrodegenerativnih bolezni
CN112824378A (zh) * 2019-11-20 2021-05-21 珠海润都制药股份有限公司 一种盐酸坦索罗辛的制备方法

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Publication number Priority date Publication date Assignee Title
DE68924751T2 (de) 1988-09-26 1996-04-11 Smithkline Beecham Farma Azacyclische Verbindungen, verwendbar als Arzneimittel.
MY110227A (en) 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
FR2681320B1 (fr) 1991-09-12 1994-01-14 Synthelabo Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
FR2681325B1 (fr) 1991-09-16 1993-12-17 Fabre Medicament Pierre Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
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AU7145996A (en) * 1995-10-13 1997-04-30 Banyu Pharmaceutical Co., Ltd. Substituted heteroaromatic derivatives

Also Published As

Publication number Publication date
CO4990939A1 (es) 2000-12-26
CA2321198C (en) 2009-11-17
HUP0100760A2 (hu) 2001-08-28
MA26610A1 (fr) 2004-12-20
AU2835399A (en) 1999-09-15
PL194037B1 (pl) 2007-04-30
HRP20000544A2 (en) 2001-02-28
EP1058680A1 (en) 2000-12-13
PL342692A1 (en) 2001-07-02
US6319920B1 (en) 2001-11-20
EP1058680B1 (en) 2008-07-09
TR200002481T2 (tr) 2000-11-21
NO317106B1 (no) 2004-08-09
CN1295563A (zh) 2001-05-16
CN1143848C (zh) 2004-03-31
CA2321198A1 (en) 1999-09-02
HUP0100760A3 (en) 2002-12-28
NO20004261L (no) 2000-08-25
KR100384906B1 (ko) 2003-05-23
YU53100A (sh) 2003-04-30
IL137936A0 (en) 2001-10-31
NZ506317A (en) 2003-08-29
NO20004261D0 (no) 2000-08-25
ATE400554T1 (de) 2008-07-15
MY133445A (en) 2007-11-30
DE69939053D1 (de) 2008-08-21
ES2310032T3 (es) 2008-12-16
AR015523A1 (es) 2001-05-02
KR20010041321A (ko) 2001-05-15
HK1036623A1 (en) 2002-01-11
AU753255B2 (en) 2002-10-10
BR9909253A (pt) 2000-11-28
JP2002504543A (ja) 2002-02-12
JP3523198B2 (ja) 2004-04-26
WO1999043657A1 (en) 1999-09-02
RU2220138C2 (ru) 2003-12-27

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