PE20000879A1 - METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO - Google Patents
METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICOInfo
- Publication number
- PE20000879A1 PE20000879A1 PE1999000315A PE00031599A PE20000879A1 PE 20000879 A1 PE20000879 A1 PE 20000879A1 PE 1999000315 A PE1999000315 A PE 1999000315A PE 00031599 A PE00031599 A PE 00031599A PE 20000879 A1 PE20000879 A1 PE 20000879A1
- Authority
- PE
- Peru
- Prior art keywords
- acid
- lactam
- crystallize
- alcoxy
- glycin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
- 150000003952 β-lactams Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- WDLWHQDACQUCJR-ZAMMOSSLSA-N (6r,7r)-7-[[(2r)-2-azaniumyl-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(e)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)/C=C/C)C(O)=O)=CC=C(O)C=C1 WDLWHQDACQUCJR-ZAMMOSSLSA-N 0.000 abstract 1
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 229960003022 amoxicillin Drugs 0.000 abstract 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 1
- 229960000723 ampicillin Drugs 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 abstract 1
- 229960005361 cefaclor Drugs 0.000 abstract 1
- OLVCFLKTBJRLHI-AXAPSJFSSA-N cefamandole Chemical compound CN1N=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)[C@H](O)C=3C=CC=CC=3)[C@H]2SC1 OLVCFLKTBJRLHI-AXAPSJFSSA-N 0.000 abstract 1
- 229960003012 cefamandole Drugs 0.000 abstract 1
- RTXOFQZKPXMALH-GHXIOONMSA-N cefdinir Chemical compound S1C(N)=NC(C(=N\O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 RTXOFQZKPXMALH-GHXIOONMSA-N 0.000 abstract 1
- 229960003719 cefdinir Drugs 0.000 abstract 1
- GPRBEKHLDVQUJE-VINNURBNSA-N cefotaxime Chemical compound N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C(O)=O)=O)C(=O)/C(=N/OC)C1=CSC(N)=N1 GPRBEKHLDVQUJE-VINNURBNSA-N 0.000 abstract 1
- 229960004261 cefotaxime Drugs 0.000 abstract 1
- 229960002580 cefprozil Drugs 0.000 abstract 1
- 229960001668 cefuroxime Drugs 0.000 abstract 1
- JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 abstract 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 abstract 1
- 229940106164 cephalexin Drugs 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- RPBAFSBGYDKNRG-NJBDSQKTSA-N epicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CCC=CC1 RPBAFSBGYDKNRG-NJBDSQKTSA-N 0.000 abstract 1
- 229960002457 epicillin Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004679 hydroxides Chemical class 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN METODO PARA CRISTALIZAR UNA ß-LACTAMA DE FORMULA I, QUE COMPRENDE LA CRISTALIZACION DE UNA ß-LACTAMA A PARTIR DE UNA SOLUCION DE ACIDO NITRICO DE pH 0.5 A 2; A UNA CONCENTRACION MAYOR DE 0,4 moles/L; MEDIANTE LA ADICION DE UNA SOLUCION ALCALINA DE AMONIACO O SAL DE HIDROXIDO; DONDE: R0 ES H, ALCOXI C1-C3; R1 ES H, DERIVADO DE ACIDO ORGANICO; Y ES CH2, O, S; Z ES UN GRUPO a, -CH2-C(-R2)=, -CH=C(R2)-, -CH2-C(=CH2)-; R2 ES H, OH, HALOGENO, ALCOXI C1-C3, ALQUILO C1-C5, CICLOALQUILO C5-C8; EL NUCLEO ß-LACTAMICO SE UNE A UN AMINOACIDO POR LA CADENA LATERAL QUE PUEDE SER D-(-)-FENILGLICINA, D-(-)-4-HIDROXIFENILGLICINA, D-(-)-2,5-DIHIDROXIFENILGLICINA, ACIDO 2-TIENILACETICO, ACIDO 2-(2-AMINO-4-TIAZOLIL)-2-METOXIIMINOACETICO, ENTRE OTROS; LA ß-LACTAMA PUEDE SER AMOXICILINA, AMPICILINA, CEFALEXINA, CEFACLOR, CEFADROXIL, CEFADRINA, EPICILINA, CEFAMANDOL, CEFOTAXIME, CEFDINIR, CEFPROZIL, CEFUROXIM, CEFEPIME, CEFIBUTEN, LORACARBEF Y SE PUEDE OBTENER DE MANERA ENZIMATICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98201398 | 1998-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000879A1 true PE20000879A1 (es) | 2000-09-23 |
Family
ID=8233663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000315A PE20000879A1 (es) | 1998-04-29 | 1999-04-16 | METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1075479A1 (es) |
| KR (1) | KR20010043038A (es) |
| CN (1) | CN1298408A (es) |
| AU (1) | AU3539599A (es) |
| BR (1) | BR9910085A (es) |
| ID (1) | ID26418A (es) |
| PE (1) | PE20000879A1 (es) |
| TR (1) | TR200003131T2 (es) |
| WO (1) | WO1999055710A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110005727A (ko) | 2002-08-13 | 2011-01-18 | 산도즈 아게 | 세프디니르 중간체 |
| US7534781B2 (en) * | 2003-03-21 | 2009-05-19 | Dsm Ip Assets B.V. | Crystalline amoxicillin trihydrate powder |
| CA2520083A1 (en) * | 2003-03-24 | 2004-10-07 | Acs Dobfar S.P.A. | Novel crystal of 7-[2-[(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) and method for preparation thereof |
| MX2007006018A (es) | 2004-11-30 | 2007-06-07 | Astellas Pharma Inc | Suspension farmaceutica oral novedosa de cristal de cefdinir. |
| BRPI0711924B1 (pt) * | 2006-05-19 | 2023-11-28 | Centrient Pharmaceuticals Netherlands B.V. | Processo para a preparação de cefadroxil monoidratado em forma de cristal |
| CN103145733B (zh) * | 2013-03-20 | 2014-02-26 | 四川省惠达药业有限公司 | 一种阿莫西林化合物及该化合物和克拉维酸钾的药物组合物 |
| CN104059086B (zh) * | 2014-06-19 | 2016-04-13 | 河南牧翔动物药业有限公司 | 一种阿莫西林晶体及其制备方法 |
| CN104830523B (zh) * | 2015-05-15 | 2018-01-09 | 湖北民族学院 | 一种高品质植物油的无公害生产装置及生产植物油的方法 |
| CN106397455B (zh) * | 2016-08-30 | 2018-08-31 | 山东罗欣药业集团恒欣药业有限公司 | 一种抗感染药物头孢布烯晶体化合物及其组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE465649A (es) * | 1944-06-19 | |||
| JPS6379888A (ja) * | 1986-09-24 | 1988-04-09 | Tanabe Seiyaku Co Ltd | ペニシリン誘導体の安定型水和物 |
| RU2024851C1 (ru) * | 1992-07-22 | 1994-12-15 | Шорманов Владимир Камбулатович | СПОСОБ ОПРЕДЕЛЕНИЯ 6-(D-α -АМИНОФЕНИЛАЦЕТАМИДО)-ПЕНИЦИЛЛАНОВОЙ КИСЛОТЫ НАТРИЕВОЙ СОЛИ |
| BE1009264A3 (nl) * | 1995-03-31 | 1997-01-07 | Dsm Nv | Werkwijze voor de winning van ampicilline. |
| AU1234999A (en) * | 1997-11-10 | 1999-05-31 | Gist-Brocades B.V. | Crystallization of beta-lactam compounds |
-
1999
- 1999-04-16 PE PE1999000315A patent/PE20000879A1/es not_active Application Discontinuation
- 1999-04-27 BR BR9910085-1A patent/BR9910085A/pt not_active Application Discontinuation
- 1999-04-27 EP EP99917236A patent/EP1075479A1/en not_active Withdrawn
- 1999-04-27 KR KR1020007011901A patent/KR20010043038A/ko not_active Application Discontinuation
- 1999-04-27 ID IDW20002187A patent/ID26418A/id unknown
- 1999-04-27 CN CN99805572A patent/CN1298408A/zh active Pending
- 1999-04-27 WO PCT/NL1999/000246 patent/WO1999055710A1/en not_active Application Discontinuation
- 1999-04-27 AU AU35395/99A patent/AU3539599A/en not_active Abandoned
- 1999-04-27 TR TR2000/03131T patent/TR200003131T2/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3539599A (en) | 1999-11-16 |
| EP1075479A1 (en) | 2001-02-14 |
| BR9910085A (pt) | 2000-12-26 |
| WO1999055710A1 (en) | 1999-11-04 |
| KR20010043038A (ko) | 2001-05-25 |
| TR200003131T2 (tr) | 2001-01-22 |
| CN1298408A (zh) | 2001-06-06 |
| ID26418A (id) | 2000-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |