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LV10086B - Hiv-inhibiting benzeneacetamide derivatives - Google Patents

Hiv-inhibiting benzeneacetamide derivatives Download PDF

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Publication number
LV10086B
LV10086B LVP-92-231A LV920231A LV10086B LV 10086 B LV10086 B LV 10086B LV 920231 A LV920231 A LV 920231A LV 10086 B LV10086 B LV 10086B
Authority
LV
Latvia
Prior art keywords
hydrogen
formula
nitro
halogen
pans
Prior art date
Application number
LVP-92-231A
Other languages
English (en)
Latvian (lv)
Other versions
LV10086A (lv
Inventor
Georges Henri Paul Van Daele
Marc Gustaaf Celine Verdonck
Jean-Paul R M A Bosmans
Paul Adriaan Jan Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of LV10086A publication Critical patent/LV10086A/xx
Publication of LV10086B publication Critical patent/LV10086B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
LVP-92-231A 1990-07-10 1992-11-27 Hiv-inhibiting benzeneacetamide derivatives LV10086B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP90201857 1990-07-10
EP91200646 1991-03-22
PCT/EP1991/001254 WO1992000952A1 (fr) 1990-07-10 1991-07-04 Derives de benzeneacetamide inhibiteurs du vih

Publications (2)

Publication Number Publication Date
LV10086A LV10086A (lv) 1994-05-10
LV10086B true LV10086B (en) 1995-02-20

Family

ID=26125946

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-92-231A LV10086B (en) 1990-07-10 1992-11-27 Hiv-inhibiting benzeneacetamide derivatives

Country Status (42)

Country Link
US (2) US5684049A (fr)
EP (1) EP0538301B1 (fr)
JP (1) JPH0819068B2 (fr)
KR (1) KR0183446B1 (fr)
CN (2) CN1028990C (fr)
AP (1) AP311A (fr)
AT (1) ATE144765T1 (fr)
AU (1) AU643056B2 (fr)
BG (1) BG61809B1 (fr)
CA (1) CA2084508A1 (fr)
CZ (1) CZ279901B6 (fr)
DE (1) DE69122963T2 (fr)
DK (1) DK0538301T3 (fr)
DZ (1) DZ1514A1 (fr)
ES (1) ES2095942T3 (fr)
FI (1) FI930070A0 (fr)
GR (1) GR3021829T3 (fr)
HR (1) HRP930485A2 (fr)
HU (2) HUT64013A (fr)
IE (1) IE75693B1 (fr)
IL (3) IL98756A (fr)
LT (1) LT3602B (fr)
LV (1) LV10086B (fr)
MA (1) MA22208A1 (fr)
MX (1) MX9100100A (fr)
MY (1) MY108580A (fr)
NO (1) NO303777B1 (fr)
NZ (1) NZ238763A (fr)
OA (1) OA09770A (fr)
PH (1) PH30977A (fr)
PL (1) PL167076B1 (fr)
PT (1) PT98259B (fr)
RO (1) RO112855B1 (fr)
RU (1) RU2087465C1 (fr)
SG (1) SG48829A1 (fr)
SI (1) SI9111204A (fr)
SK (1) SK279639B6 (fr)
TN (1) TNSN91056A1 (fr)
TW (1) TW204337B (fr)
WO (1) WO1992000952A1 (fr)
YU (1) YU120491A (fr)
ZA (1) ZA915334B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0620809B1 (fr) * 1991-12-30 1997-03-05 Janssen Pharmaceutica N.V. DERIVES DE BENZENEMETHANAMINE A SUBSTITUTION $g(a)
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
EP0577945B1 (fr) * 1992-07-06 1996-08-14 American Cyanamid Company o-Nitrophenyl cyclopropyl cétone, intermédiaire pour herbicides et procédé pour sa préparation
JP2669937B2 (ja) * 1993-02-22 1997-10-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノート シヤツプ ジドブジンに対するｈｉｖ−１株の耐性を逆転させる方法
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
GB9403408D0 (en) * 1994-02-23 1994-04-13 Wellcome Found Therapeutic benzonitriles
GB9403449D0 (en) * 1994-02-23 1994-04-13 Wellcome Found Therapeutic benzonitriles
IL112739A0 (en) * 1994-02-23 1995-05-26 Wellcome Found Ayrlthiobenzonitrile compounds, their preparation and pharmaceutical compositions containing them
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
EP0872233A1 (fr) * 1997-04-14 1998-10-21 Janssen Pharmaceutica N.V. Médicaments antirétroviraux à biodisponibilité améliorée
YU9600A (sh) * 1997-08-22 2002-03-18 F. Hoffmann-La Roche Ag. Derivati n-alkanoilfenilalanina
DE69932820T4 (de) * 1998-06-19 2008-06-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thiolester und ihre anwendungen
AP1639A (en) 1999-09-24 2006-07-24 Janssen Pharmaceutica Nv Pharmaceutical compositions of antiviral compounds and processes for preparation.
KR100785675B1 (ko) * 2000-08-11 2007-12-14 니뽄 다바코 산교 가부시키가이샤 칼슘 수용체 길항약
MXPA06012252A (es) * 2004-04-23 2006-12-15 Hoffmann La Roche Compuestos no nucleosidos que inhiben la transcriptasa inversa.
US7625949B2 (en) 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
EP2061756B1 (fr) * 2006-06-08 2013-09-25 Bristol-Myers Squibb Company 2-aminocarbonylphenylamino-2-phenyl comme inhibiteurs de facteur viia utiles en tant qu'anticoagulants
RU2449985C2 (ru) * 2010-03-31 2012-05-10 Федеральное государственное унитарное предприятие "Российский научный центр "Прикладная химия" Способ получения n,n-диметилацетамида
CN102675212B (zh) * 2012-05-09 2014-11-05 昆明理工大学 N-取代苯基-2-((1h-苯并咪唑-2-基)巯基)乙酰胺类衍生物及其用途
CN104000807B (zh) * 2014-05-28 2016-05-18 中山大学 苯基-酰胺类化合物在制备抗hiv-1病毒药物中的应用
CN105367437B (zh) * 2015-10-12 2017-08-01 湖北文理学院 一种2‑芳氨基乙酰胺类化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1423430A (en) * 1973-03-29 1976-02-04 Wyeth John & Brother Ltd Thioamides
US4246429A (en) * 1978-06-23 1981-01-20 Janssen Pharmaceutica, N.V. Novel α-amino-phenylacetic acid derivatives
CH637828A5 (en) * 1978-11-15 1983-08-31 Koehler Franz Dr Chemie Kg Cytostatics
EP0620809B1 (fr) * 1991-12-30 1997-03-05 Janssen Pharmaceutica N.V. DERIVES DE BENZENEMETHANAMINE A SUBSTITUTION $g(a)

Also Published As

Publication number Publication date
SI9111204A (en) 1995-04-30
CN1033142C (zh) 1996-10-30
DE69122963D1 (de) 1996-12-05
DZ1514A1 (fr) 2004-09-13
CA2084508A1 (fr) 1992-01-11
RU2087465C1 (ru) 1997-08-20
AP311A (en) 1994-02-01
MA22208A1 (fr) 1992-04-01
NO930047L (no) 1993-01-07
HU9300032D0 (en) 1993-04-28
IL98756A (en) 1996-06-18
ATE144765T1 (de) 1996-11-15
AU643056B2 (en) 1993-11-04
NO303777B1 (no) 1998-08-31
SG48829A1 (en) 1998-05-18
NO930047D0 (no) 1993-01-07
NZ238763A (en) 1993-10-26
CN1058958A (zh) 1992-02-26
AU8212091A (en) 1992-02-04
OA09770A (fr) 1993-11-30
CN1028990C (zh) 1995-06-21
SK279639B6 (sk) 1999-01-11
PT98259B (pt) 1998-12-31
IL111924A (en) 1996-12-05
TNSN91056A1 (fr) 1992-10-25
LT3602B (en) 1995-12-27
FI930070A7 (fi) 1993-01-08
LV10086A (lv) 1994-05-10
DK0538301T3 (da) 1996-11-25
JPH0819068B2 (ja) 1996-02-28
GR3021829T3 (en) 1997-02-28
SK210291A3 (en) 1995-07-11
BG97265A (bg) 1994-03-24
YU120491A (sh) 1994-06-10
EP0538301A1 (fr) 1993-04-28
US5684049A (en) 1997-11-04
HUT64013A (en) 1993-11-29
IL111924A0 (en) 1995-03-15
EP0538301B1 (fr) 1996-10-30
ZA915334B (en) 1993-03-31
FI930070A0 (fi) 1993-01-08
MX9100100A (es) 1992-02-28
CZ279901B6 (cs) 1995-08-16
TW204337B (fr) 1993-04-21
HU211873A9 (en) 1995-12-28
US5556886A (en) 1996-09-17
PL297608A1 (fr) 1992-07-13
JPH05507931A (ja) 1993-11-11
AP9100288A0 (en) 1991-07-31
WO1992000952A1 (fr) 1992-01-23
IL98756A0 (en) 1992-07-15
IE912208A1 (en) 1992-01-15
DE69122963T2 (de) 1997-03-13
RO112855B1 (ro) 1998-01-30
CS210291A3 (en) 1992-02-19
LTIP848A (en) 1995-02-27
PH30977A (en) 1997-12-23
CN1107835A (zh) 1995-09-06
MY108580A (en) 1996-10-31
IE75693B1 (en) 1997-09-10
BG61809B1 (bg) 1998-06-30
ES2095942T3 (es) 1997-03-01
PT98259A (pt) 1992-04-30
KR0183446B1 (ko) 1999-05-15
PL167076B1 (pl) 1995-07-31
HRP930485A2 (en) 1996-06-30

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