KR101732082B1 - valves of the heart for a ventricular assist device - Google Patents

Abstract

The present invention introduces the concept of reversing the inside and outside of the valve, thereby providing a heart valve that is simple to manufacture, high in durability and flexibility, and excellent in effectiveness. Specifically, the heart valves 100, 200 and the support 300 include valve plates 100, 200 that are configured such that the valve inner wall portions 101, 201 are located on the outer side and the valve outer skin 102, And the grooves 110 and 210 are located in the plate-membrane endothelium portions 101 and 201 of the plate membranes 100 and 200, respectively.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a heart valve for a ventricular assist device,

The present invention relates to a heart valve for a ventricular assist device, and more particularly, to a heart valve which is easy to manufacture and has an excellent effect by introducing the concept of reversing the inside and outside of the valve.

The number of patients with heart disease is increasing year by year. Although it may be possible to slow or improve the progression of the disease by performing a steady and continuous treatment of the patient with heart disease, a considerable number of patients have end-stage heart disease. Currently, cardiac transplantation is virtually the only treatment for patients with end-stage heart disease, but donors are reported to be only about 10% of patients.

The ventricular assist device (VAD) has been proposed as an effective alternative to a variety of heart diseases, as well as patients waiting for donors. It also helps to reduce the mortality rate from heart diseases It is helpful.

The ventricular assist device is a kind of cardiopulmonary bypass device which is inserted into the body while pumping the blood through a separate power source. Patients who are waiting for a donor and those who are transplanted with a heart, as well as patients who need a function before a heart transplant are also used for patients with heart failure who are substantially unable to perform surgical treatment including medical treatment or open heart surgery.

One of the two tubes connected to the pump acting as a pump among the various types of ventricular assist devices is a left ventricular assist device (LVAD), which connects the left ventricle and the other to the aorta, thereby extracting a portion of the blood in the left ventricle and delivering it to the aorta. (RVAD), bi-axial assist device (BiLAD), etc., and may be classified into a hydraulic type or a mechanical type depending on the power source.

Generally, ventricular assist devices use two heart valves, one on the inlet side and the other on the outlet side (see FIG. 7).

These heart valves require various functions. It is natural that the flow of the flow should be controlled only in one direction so that the blood does not flow backward. Durability is needed so that the blood flows more than a dozen times a minute and can be firmly supported. In addition, the flexibility of the material itself is also required so that the blood can flow constantly without being clumped or clumped.

The heart valves are classified into a bi-leaflet valve or a tri-leaflet valve depending on the type thereof. FIG. 1A shows a conventional tri-leaf valve. A flexible material member formed of a tri-leaf type valve is firmly fixed to a support of the type shown in FIG. 1B.

Except for the support used herein, the material of the valve part may vary. The conventional heart valve can be classified into mechanical valve using special alloy, tissue valve using mainly pig valve, polymer valve made of polymer, and the like. However, each valve has pros and cons.

Mechanical valves have good durability but there is a problem that the blood coagulates on the surface. To solve this problem, there is a problem that the anticoagulant should be continuously administered, and the valve is opened and the noise is generated at the moment of closing.

In the case of the tissue valve, the most natural operation was performed. However, there was a problem that a rejection reaction could occur with respect to a specific blood, a problem that the durability was low, and therefore, a heart valve had to be replaced every 10 years.

Polymeric valve membranes have been researched recently because they have the advantage that they can be formed relatively freely compared with mechanical valves and tissue valves, and that they have better durability than tissue valve membranes.

However, it is very difficult to eject in the form of a desired valve film even in a polymer valve film. It is difficult to directly obtain an injection molded article having a complicated shape as shown in FIG. 1A, but the durability is lowered when the respective leaflets are separately molded and fused. Accordingly, it is recognized that the polymer film has a high degree of freedom but a high degree of manufacturing difficulty, and further, some errors that may occur during manufacturing may be fatal to the user.

Further, the rigidity of the polymer itself is low. A separate support as shown in FIG. 1B is indispensable, and the rigidity or flexibility varies depending on how the polymer film is connected to the support.

(Patent Document 1) US 11 / 775,043

(Patent Document 2) US 11 / 700,922

(Patent Document 3) KR 10-1037077

(Patent Document 4) KR 10-0033339

SUMMARY OF THE INVENTION The present invention has been made to solve the above problems.

A method of providing a heart valve using a polymer valve having advantages, which is a disadvantage of a polymer valve, and which can overcome manufacturing difficulties, and a heart valve manufactured by the method are proposed.

At the same time, we propose a heart valve that can be used without any long-term replacement due to its high durability, and can solve the problem of coagulation of blood due to its flexibility and flexibility in connection with the support

Furthermore, we propose a heart valve that can produce any kind of valve, whether it is a bifurcated valve or a trilobal valve in the same manufacturing line by varying the number of grooves.

One embodiment of the present invention for solving the above problems is a heart valve including valve plates 100 and 200 and a support 300. The valve plates 100 and 200 are formed by the plate- In which the grooves 110 and 210 are located on the plate inner wall portions 101 and 201 of the plate membranes 100 and 200 and in which the outer wall portions 102 and 202 of the plate membranes 100 and 200 are located on the inner side, Valve.

The grooves 110 and 210 are formed downward from the top of the plate films 100 and 200 but do not extend to the bottom of the plate films 100 and 200, It is preferable that the thickness is reduced but the thickness of the lower portion is not reduced.

The valve plates 100 and 200 may be bi-leaflet valves or a bi-leaflet valve in a second configuration in which the valve inner wall portions 101 and 201 are located on the inner side and the outer valve skin membranes 102 and 202 are located on the outer sides. Preferably in the form of a tri-leaflet valve.

In addition, it is preferable that the plate films 100 and 200 have a circular shape in the lower part in the second form and a plurality of leaflets 130 and 230 are exposed in the upper part and slits 140 and 240 are formed therebetween .

The portion of the upper portion of the plate 100 in which the grooves 110 and 210 are not provided is the portion of the plates 130 and 230 in the second form of the plate 100, .

It is preferable that the support 300 has a U-shaped plate inserting portion 307 formed therein and the plate films 100 and 200 are inserted into the plate inserting portion 307 and fixed.

The U-shaped end portions 150 and 250 are formed by folding the lower ends of the plate membranes 100 and 200 of the second embodiment outward by a predetermined length and the U-shaped end portions 150 , 250 are inserted.

The outer end surface of the U-shaped end portion 150 and 250 is formed in a radial shape and protrudes radially outward. The U-shaped end portion 150 and the U-shaped end portion 150 are formed so as to contact the radially outer end surface of the support 300 below the protruded outer end surface. The distal ends 150 and 250 are preferably inserted into the support 300.

It is preferable that the fixing ring insertion portions 157 and 257 are formed inside the U-shaped end portions 150 and 250 and the fixing ring 400 is inserted into the fixing ring insertion portions 157 and 257.

A plurality of seam holes 305 are radially disposed on the inner surface of the support 300 and a seam 500 for connecting the plurality of seam holes 305 to the plate membrane endothelium 101, ) Is further preferably provided.

In addition, the plate films 100 and 200 have a fixing table insertion slot 120 and 220 at corners thereof and a plurality of fixing plates 310 are disposed on the supporting plate 300, May be inserted into the fixing groove insertion grooves (120, 220).

The fixed plate insertion grooves 120 and 220 in the second form of the plate films 100 and 200 are formed in the grooves 110 and 210 in the first form of the plate films 100 and 200 .

In addition, it is preferable that the second shape of the plate 100, 200 is formed by inverting the first and second shapes of the plate 100, 200 so that the inside and the outside of the plate 100 are reversed.

In the case where the valve plate 100 is a bipartite valve plate in the second mode, the grooves 110 are two, and when the valve plate 200 is a triple valve plate in the second mode, It is preferable to have three.

According to the invention, it is possible to provide a heart valve comprising the desired form, i. E. Leaf or trilobal valve, in a very simple manner.

In particular, it is not necessary to inject the film in the form of a complicated shape, and since it is integrally formed, a separate welding process is not required, and the durability is high.

In addition, it is possible to have a shape of the valve sufficiently by injecting a circular valve film without a separate support and inverting it.

Of course, a more solid structure can be achieved by adding a support. The present invention is simple, robust, and natural to connect with the support. In addition, flexibility with respect to the support is high, and thus the problem of blood coagulation is solved.

As a result, it is possible to provide the most similar and rigid valve, heart valve and ventricular assist device to a real heart valve.

Figure 1 shows a heart valve according to the prior art.
Fig. 2 shows a first embodiment and a second embodiment of the bibulous valve according to the present invention.
Fig. 3 shows a first type and a second type of triple valve type valve according to the present invention.
FIGS. 4A and 4B illustrate a first embodiment of a heart valve having a bifurcated valve according to the present invention as an exploded view and a perspective view, and FIGS. 4C and 4D show a heart valve having a bifurcated valve according to the present invention. The first embodiment is shown as an exploded view and a perspective view.
FIG. 5A shows a second embodiment of a heart valve having a bifurcated valve according to the present invention, and FIG. 5B shows a second embodiment of a heart valve having a valve according to the present invention.
6 is a flowchart illustrating a method for manufacturing a heart valve according to the present invention.
FIG. 7 is a flowchart illustrating an operation method of a ventricular assist device to which a heart valve according to the present invention is applied.

For the sake of explanation, the upper side will be referred to as an upper side and the lower side as a lower side in Figs. 2 to 5 with reference to the drawings.

In the art, a heart valve serves as a kind of valve, so that a valve and a valve are used in combination. In this specification, the valve is one of the members constituting a heart valve. .

Hereinafter, the present invention will be described in detail with reference to the drawings.

1. Description of Heart Valve

The heart valve includes valve plates (100, 200) and a support (300).

FIG. 2 shows a heart valve including a bifurcated valve 100, and FIG. 3 shows a heart valve including a triphasic valve 200.

Any of the biocompatible polymers having elasticity can be used as the material of the valve plates 100 and 200. In one embodiment, it may be biocompatible silicone or medical silicone.

The top view of FIG. 2 shows a first form of bibulous valve 100.

The bibulous valve plate 100 is cylindrically extruded in the same manner as the first embodiment, and then inverted inward and outward to a second configuration shown in the lower part of FIG. 2, wherein the support 300 is fixed to be a heart valve . That is, in the second embodiment, it is in the form of a bifurcated valve. Accordingly, in the upper drawing of Fig. 2, the reference numeral 101 shown outside is the endothelium of the plate, and the reference numeral 102 shown inside is the outer skin of the valve.

The manufacturer ejects the leaf blade valve 100 in the form shown in the upper drawing of Fig.

That is, the plate-membrane endothelium 101 is located outside, and the outer membrane 102 of the valve is positioned so as to be located inside. The plate-membrane endothelium 101 is provided with two grooves 110.

The groove 110 starts from the upper portion of the bibulous plate 100 and does not reach the lower portion but ends at the middle portion.

In one embodiment, as shown in the upper diagram of FIG. 2, the grooves 110 may start at a portion of the upper portion of the bi-layer valve 100, but may be semi- . In another embodiment, not shown, the grooves 110 start at a portion of the upper portion of the bifilar plate 100, but may be slightly reduced in thickness and terminated in the middle.

Importantly, since the groove 110 starts from the upper portion but does not reach the lower portion, the thickness of the groove is reduced at the upper portion of the bifurcated valve plate 100 where the groove 110 is located, but there is no decrease in thickness at the lower portion.

When the bioredimental valve 100 manufactured in this manner is turned over so that the manufacturer changes the inside and outside, the second type is shown in the lower view of FIG. The plate endothelial portion 101 of the bibulous plate 100 is now positioned inward and the outer plate skin 102 is exposed to the outside.

At this time, in the process of reversing the inside and outside of the leaf spring plate 100, one part of the upper part having a reduced thickness due to the grooves 110 is naturally bent and gathered due to the elasticity of the material, The part will remain straight. As will be described later, the gathered portion is the fixed plate insertion groove 120, and the portion where the straight line is maintained is the leaflet 130.

Since the grooves 110 are not yet reached, there is no narrowed portion, and a constant lower portion maintains its original shape.

2, when the two-leaf type valve plate 100 is injected into the first shape as shown in the upper drawing of FIG. 2 and then inverted so that the inside and the outside of the valve plate are reversed, As shown in FIG.

The second type as shown in the lower view of FIG. 2 is in the form of a valve which can be used as a heart valve. As described above in the prior art, direct injection of a valve in such a complicated form is difficult, After the valve is injected in a first easy-to-cylindrical form, it is turned over so as to change the inside and the outside.

Therefore, the injection of the valve can be easily and easily performed, and the complicated form of the valve can be reproduced in addition to the process of reversing the inside and the outside. Furthermore, the durability is excellent because the leaflets are formed integrally without being separated.

Due to this process, the following structure is formed and revealed in the second embodiment of the leaf blade-type plate 100.

The lower part of the double leaf type valve 100 is circular. So that it can be hermetically connected to the circular support 300.

Two opposing leaflets 130 are formed and exposed on the upper side of the leaf blade 100, and a slit 140 is formed therebetween. Due to this, it can be opened only under certain conditions, and can be closed naturally by elasticity, so that one-way blood transfer is possible. As a result, the leaflet 130 is a portion in which the groove 110 is absent in the first embodiment.

The corners of the leaf valve 100 are portions where the grooves 110 are located in a portion where the thickness is relatively thin and warped in the process of being turned upside down. In the second embodiment, which will be described later with reference to FIG. 5A, the corresponding corner portion is used as the fixing member insertion groove 120. The fixing member 310 provided on the supporting member 300 may be inserted in a shape corresponding to the shape of the fixing member 310 so that the biasing member 100 and the supporting member 300 are firmly fixed.

Since it is naturally formed by elasticity, flexibility is high. This solves the problem of blood clotting, which usually occurs in mechanical valves.

In addition, in the first embodiment described later, the U-shaped distal end portion 150 is folded outward once again, and in the second embodiment described later, fixing can be performed using the fixing table 310, Durability problems or frequent replacement problems are solved.

The triple valve type film 200 is manufactured by the same process by changing only the number of the grooves 201. In other words, if the number of the grooves is two, it becomes a bifurcated valve, and if three, it becomes a triple valve.

The top view of FIG. 3 shows a first form of the tri-leaf valve 200.

That is, the triple valve type film 200 is also injected in the same shape as the first type, then inverted so that the inside and the outside of the triple valve type film 200 are reversed to form the second type shown in the lower drawing of FIG.

The grooves 210 also start from the top of the triple leaf type valve 200 and do not extend to the bottom of the triple valve type valve 200 but terminate at the middle point. However, unlike the leaf type valve 100, The shape of the triple-leaf type valve 200 may be any one of the three types without any decrease in the thickness of the triple-leaf type valve 200,

When the manufacturer of the tri-leaf type valve 200 manufactured in this manner is turned over so as to change its inside and out, the valve of the second type as shown in the lower view of FIG. 3 is obtained. Due to the difference in thickness, the shape shown in the lower drawing of Fig. 3 is formed.

Also, the bottom of the tri-leaf valve 200 is circular and can be sealingly connected to the support 300.

Three leaflets 230 are formed on the triple leaf type plate 200, and a slit 240 is formed in the center between the leaflets 230.

Three sides where the grooves 210 are located in the side of the triple-leaf type valve 200, that is, the first type, are naturally bent to form corners and used as the fixing table insertion grooves 220 in the second embodiment described later in FIG. 5B . The fixing plate 310 provided on the supporting member 300 is inserted therein, thereby firmly fixing the triple valve type plate 200 and the supporting member 300.

2. Description of Heart Valve Manufacturing Method

6, the valve 100, 200 is injected (S410), the valve is inverted (S420), and the support 300 is secured (S430) to manufacture a heart valve .

All heart valves manufactured in this manner within the scope of the claims will be included in the scope of protection of the present invention, but two exemplary methods thereof, namely the first embodiment shown in Figs. 4A to 4D, The second embodiment shown in Figs. 5A to 5B will be described in detail.

(1) First Embodiment

FIGS. 4A to 4B show a heart valve using the bifurcated valve 100, and FIGS. 4C to 4D show a heart valve using the triple valve valve 200, but they are manufactured by the same method and will be described together.

First, the valve plates 100 and 200 are injected in a first form shown in the upper drawing of FIGS. 2 and 3, that is, in a cylindrical form so that the grooves 110 and 210 are exposed outside (S410).

In another embodiment, after the complete cylinder is injected, a separate process may be added to form grooves 110 and 210 to form the first form of the valve 100, 200.

Next, the second shape is formed by inverting the inside and outside of the valve plates 100 and 200 (S420). As a result, the outer skin 102, 202 is exposed and the slits 140, 240 are formed by separating the leaflets 130, 230.

The process of reversing the inside and outside of the valve plates 100 and 200 is preferably carried out automatically by using a separate mechanical equipment to improve the productivity.

Next, the lower end portions of the plate membranes 100, 200 of the second form are folded outward by a predetermined length to form the U-shaped end portions 150, 250. Since it is U-shaped, the fixing ring insertion portions 157 and 257 are formed on the inner side. The folding length, that is, the predetermined height of the U-shaped end portions 150, 250, may be appropriate for the seam 500.

A support 300 having a U-shape is prepared. Due to the shape, the valve insertion portion 307 is formed on the inner side. The support 300 may be made of a biocompatible or non-toxic metal to a polymeric material and thus performs a fixing function. Also, as will be described below, a plurality of seam holes 305 may be provided radially on the inner surface for embodiments using the seam 500.

The U-shaped end portions 150 and 250 are now inserted into the valve insert 307 of the support 300 so that the support 300 will wrap around the U-shaped end portions 150 and 250.

In another embodiment, the valve 100, 200 in the unfolded state, i.e., the second form shown in the lower view of Figures 2 and 3, but not the U-shaped end 150, 250, have.

In another embodiment, as shown in the detailed cross-sectional views of FIGS. 4B and 4D, the outer end face of the U-shaped end portions 150, 250, that is, the lower face of the second type of valves 100, 200, And may be inserted such that the radially outer end surface of the support 300 abuts below the protruded outer end surface. This makes it possible to more firmly fix the plate 100, 200 and the support 300.

Meanwhile, the fixing ring 400 is inserted and fixed to the fixing ring insertion portions 157 and 257 inside the U-shaped distal end portions 150 and 250. The retaining ring 400 is preferably a biocompatible or non-toxic metal to polymeric material as an O-ring.

In other embodiments, the U-shaped end portions 150, 250 and the support 300 may be rigidly secured without the retaining ring 400. [

Although only the various embodiments described may function as a heart valve, in yet another embodiment seam 500 may be added to further enhance durability. That is, the inner surface of the support 300 may further include a seam 500 passing through the plurality of seam holes 305 positioned radially and connecting the endothelial sections 101 and 201 to the supporter 300. The seam 500 may be a medical room. Such a seam 500 will not be visible outside of the manufactured heart valve and will only be visible from the inside.

Thereby, as shown in the detailed cross-sectional views shown in Figs. 4B and 4D, the U-shaped distal end portions 150, 250 of the support 300, the valve plates 100, 200, the stationary ring 400 The U-shaped end portions 150 and 250, and the support body 300 are sequentially positioned.

(2) Second Embodiment

As in the first embodiment, the valve plates 100 and 200 are injected in a first form, i.e., a cylindrical form (S410). After the complete cylinder is injected, a separate process may be added to form grooves 110 and 210 to form the first form of the valve 100, 200.

Next, the second shape is formed by inverting the inside and outside of the valve plates 100 and 200 (S420). As a result, the outer skin 102, 202 is exposed and the slits 140, 240 are formed by separating the leaflets 130, 230. In addition, the fixing rod insertion grooves 120 and 220 are formed at the corner portions.

The support 300 is prepared. The support 300 prepared in the second embodiment is different from the support in the first embodiment in that a separate fixing table 310 is formed. Two for the leaf valve 100 and three for the three valve valve 200 are prepared.

The support 300 is fixed to the plate films 100 and 200 so that the fixing table 310 is inserted into the fixing table insertion grooves 120 and 220 formed in the second mode.

3. Description of how the ventricular assist device works

The operation principle of the ventricular assist device to which the heart valve according to the present invention is applied will be described with reference to FIG. Although the bipartite valve 100 is shown in the figure, the same principle applies to the triple valve 200 as well.

Two heart valves are provided at the inlet and two at the outlet.

The inlet, the first heart valve, the second heart valve and the outlet are sealingly connected to the flexible conduit (3).

The two heart valves and the conduit 3 portion therebetween are surrounded by the chamber 1 and a pumping tube 2 connected to a pump (not shown) is provided at one side of the chamber 1.

As shown in FIG. 7 (a), when the air inside the chamber 1 is discharged by the pumping tube 2, the conduit 3 expands as the negative pressure is formed.

As a result, the first heart valve at the inlet side is opened and the blood flows through it. At the same time, in the case of the second heart valve located at the outlet side, no backwash occurs because it is further compressed.

Then, as shown in Fig. 7 (b), when air is supplied to the inside of the chamber 1 by the pumping tube 2, a positive pressure is formed.

Conversely, the first heart valve at the inlet side is squeezed and the second heart valve at the outlet side is opened to allow blood to pass through.

This process is repeated, and blood movement is performed.

While the present invention has been described with reference to exemplary embodiments thereof, it will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention as defined by the following claims. It will be appreciated that embodiments are possible. Accordingly, the scope of protection of the present invention should be determined by the claims.

1: chamber
2: pumping pipe
3: conduit
100: The valve (leaf valve)
200: valve (triple valve)
101, 201:
102, 202: external skin of the valve
110, 120: Home
120, 220: Fixture insertion groove
130, 230: leaflet
140, 240: slit
150, 250: U-shaped end
157, 257: fixed ring insertion portion
300: support
305: Seam hole
307:
310:
400: stationary ring
500: Seam

Claims (15)

A heart valve comprising a valve (100, 200) and a support (300)
The valve plates 100 and 200 are cylindrically shaped in the first configuration in which the plate inner membrane 101 and 201 are located on the outer side and the outer membrane 102 and 202 are located on the inner side,
The grooves 110 and 210 are located in the plate-membrane endothelium portions 101 and 201 of the plate membranes 100 and 200,
The grooves 110 and 210 are formed downward from the upper part of the plate 100, 200,
Heart valve.
The method according to claim 1,
The thicknesses of the upper portions of the valve plates 100 and 200 are decreased by the grooves 110 and 210,
Heart valve.
The method according to claim 1,
The valve plates 100 and 200 may be bi-leaflet valves or triple valves in the second configuration in which the valve inner membrane 101 and 201 are located on the inner side and the outer membrane 102 and 202 are located on the outer side, In the form of a tri-leaflet valve,
Heart valve.
The method of claim 3,
The valve plates 100 and 200 have a circular shape in the lower part and a plurality of leaflets 130 and 230 in the upper part and slits 140 and 240 are formed therebetween.
Heart valve.
5. The method of claim 4,
A portion of the upper portion of the valve plate 100 or 200 in the upper portion without the grooves 110 and 210 is the portion of the leaflets 130 and 230 in the second form of the valve plate 100 or 200,
Heart valve.
The method of claim 3,
The supporter 300 has a U-shaped plate inserting portion 307 formed therein and the plate films 100 and 200 are inserted into the plate inserting portion 307,
Heart valve.
The method according to claim 6,
The lower ends of the valve plates 100 and 200 of the second embodiment are folded outward by a predetermined length to form the U-shaped end portions 150 and 250,
The U-shaped distal end (150, 250) is inserted into the valve insert 307,
Heart valve.
8. The method of claim 7,
The U-shaped distal end (150, 250) has an outer end surface formed to be radially projected radially outward, and the U-shaped distal end 150, 250 are inserted into the support 300,
Heart valve.
8. The method of claim 7,
Wherein the fixing ring insertion portions 157 and 257 are formed inside the U-shaped end portions 150 and 250 and the fixing ring 400 is inserted into the fixing ring insertion portions 157 and 257,
Heart valve.
10. The method of claim 9,
A plurality of seam holes 305 are radially positioned on the inner surface of the support 300 and a seam 500 connecting the plurality of seam holes 305 to the plate membrane endothelium 101, Further,
Heart valve.
The method of claim 3,
In the second form of the plate 100, 200, the fixing plate insertion grooves 120, 220 are located at the corners,
A plurality of fixing bars 310 are located on the support 300 and the fixing bars 310 can be inserted into the fixing bar insertion grooves 120,
Heart valve.
12. The method of claim 11,
The fixing table insertion grooves 120 and 220 in the second form of the plate films 100 and 200 are formed in the grooves 110 and 210 in the first form of the plate films 100 and 200,
Heart valve.
The method of claim 3,
Wherein the first and second shapes of the valve plates (100, 200) are reversed so that the first and second valve plates (100, 200)
Heart valve.
The method of claim 3,
In the case where the valve plate 100 is a bipartite valve plate in the second mode, the grooves 110 are two, and when the valve plate 200 is a triple-leaf type valve in the second mode, ,
Heart valve.
A heart valve comprising a heart valve according to any one of claims 1 to 14,
Ventricular assist device.

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