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JPWO2022047193A5 - - Google Patents

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JPWO2022047193A5
JPWO2022047193A5 JP2023513613A JP2023513613A JPWO2022047193A5 JP WO2022047193 A5 JPWO2022047193 A5 JP WO2022047193A5 JP 2023513613 A JP2023513613 A JP 2023513613A JP 2023513613 A JP2023513613 A JP 2023513613A JP WO2022047193 A5 JPWO2022047193 A5 JP WO2022047193A5
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histotripsy
cavitation
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ヒストトリプシシステム用の送受信駆動電子機器であって、
送信モードで超音波パルスを送信し、受信モードで超音波反射および／または音響キャビテーション放射を受信するように構成された少なくとも１つのトランスデューサ要素と、
前記受信モード中に前記送受信駆動電子機器における電流を測定するように構成された電流検知抵抗器と、
前記少なくとも１つのトランスデューサ要素および前記電流検知抵抗器に電気的に結合されたバイパス回路であって、前記電流検知抵抗器をバイパスするために、前記送信モード中にオンに切り替えられ、前記電流検知抵抗器が前記電流を測定することを可能にするために、前記受信モード中にオフに切り替えられるように構成されたバイパス回路と、
前記電流検知抵抗器および低感度抵抗器に電気的に結合された利得調整回路であって、前記電流検知抵抗器がオンに切り替えられ、前記低感度抵抗器がオフに切り替えられる高感度設定において動作するように構成され、前記電流検知抵抗器および前記低感度抵抗器がオンに切り替えられる低感度設定で動作するようにさらに構成される、利得調整回路と
を備える、送受信駆動電子機器。 A transmitter/receiver driver electronics for a Histotripsy system, comprising:
at least one transducer element configured to transmit ultrasonic pulses in a transmit mode and to receive ultrasonic reflections and/or acoustic cavitation radiation in a receive mode;
a current sense resistor configured to measure a current in the transmit/receive driver electronics during the receive mode;
a bypass circuit electrically coupled to the at least one transducer element and the current sense resistor, the bypass circuit being configured to be switched on during the transmit mode to bypass the current sense resistor and to be switched off during the receive mode to allow the current sense resistor to measure the current;
and a gain adjustment circuit electrically coupled to the current sensing resistor and the low sensitivity resistor, the gain adjustment circuit being configured to operate at a high sensitivity setting where the current sensing resistor is switched on and the low sensitivity resistor is switched off, and further configured to operate at a low sensitivity setting where the current sensing resistor and the low sensitivity resistor are switched on. 前記少なくとも１つのトランスデューサ要素に電気的に結合された駆動変圧器をさらに備える、請求項１に記載の送受信駆動電子機器。 The transmit/receive driving electronics of claim 1, further comprising a driving transformer electrically coupled to the at least one transducer element. 前記バイパス回路はさらに、一対のバイパストランジスタを備える、請求項１に記載の送受信駆動電子機器。 The transmission/reception driving electronic device according to claim 1, wherein the bypass circuit further comprises a pair of bypass transistors. 前記バイパス回路はさらに、一対のバイパスダイオードを備える、請求項１に記載の送受信駆動電子機器。 The transmitter/receiver driving electronic device according to claim 1, wherein the bypass circuit further comprises a pair of bypass diodes. 前記利得調整回路はさらに、一対のトランジスタを備える、請求項１に記載の送受信駆動電子機器。 The transmission/reception driving electronic device according to claim 1, wherein the gain adjustment circuit further comprises a pair of transistors. 前記電流検知抵抗器は、前記低感度抵抗器よりも高い抵抗を有する、請求項１に記載の送受信駆動電子機器。 The transmit/receive driver electronic device of claim 1, wherein the current sensing resistor has a higher resistance than the low sensitivity resistor. 前記電流検知抵抗器は、約２００オームの抵抗を有し、前記低感度抵抗器は、約５オームの抵抗を有する、請求項１に記載の送受信駆動電子機器。 The transmit/receive driver electronic device of claim 1, wherein the current sensing resistor has a resistance of about 200 ohms and the low sensitivity resistor has a resistance of about 5 ohms. ヒストトリプシシステム用の送受信駆動電子機器であって、
超音波トランスデューサアレイと、
前記超音波トランスデューサアレイに結合され、１つまたは複数のヒストトリプシパルスを生成するために、前記超音波トランスデューサアレイに最大数千ボルトを提供するように構成された高電圧送信電子機器と、
前記超音波トランスデューサアレイに結合され、送信された１つまたは複数のヒストトリプシパルスからの入力電圧信号を受信するように構成された第１の受信電子機器であって、前記入力電圧信号を、９０～９９％減衰させるように構成された、第１の受信電子機器と、
１Ｖを超えるすべての減衰された入力電圧信号を圧縮するように構成された第２の受信電子機器と、
前記減衰された入力電圧信号を電圧シフトするように構成された第３の受信電子機器と、
ＡＤＣ変換のために、前記第３の受信電子機器から、前記電圧シフトされた減衰された入力電圧信号を受信するように構成されたアナログデジタル変換器と
を備える、送受信駆動電子機器。 A transmitter/receiver driver electronics for a Histotripsy system, comprising:
an ultrasonic transducer array;
high voltage transmit electronics coupled to the ultrasound transducer array and configured to provide up to several thousand volts to the ultrasound transducer array to generate one or more histotripsy pulses;
a first receive electronics coupled to the ultrasonic transducer array and configured to receive an input voltage signal from one or more transmitted histotripsy-pulses, the first receive electronics configured to attenuate the input voltage signal by 90-99%;
second receiving electronics configured to compress all attenuated input voltage signals above 1 V;
a third receiver electronics configured to voltage shift the attenuated input voltage signal;
and an analog-to-digital converter configured to receive the voltage-shifted, attenuated input voltage signal from the third receive electronics for ADC conversion. 前記第１の電子機器は、分圧器を備える、請求項８に記載の送受信駆動電子機器。 The transmit/receive driving electronic device according to claim 8, wherein the first electronic device comprises a voltage divider. 前記分圧器は、容量性分圧器を備える、請求項９に記載の送受信駆動電子機器。 The transmit/receive driving electronic device of claim 9, wherein the voltage divider comprises a capacitive voltage divider. 前記容量性分圧器は、前記超音波トランスデューサアレイの第１のトランスデューサ要素と並列の、第１のコンデンサおよび第２のコンデンサを備える、請求項１０に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 10, wherein the capacitive voltage divider comprises a first capacitor and a second capacitor in parallel with a first transducer element of the ultrasonic transducer array. 前記第２の受信電子機器は、ダイオード抵抗分圧器を備える、請求項８に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 8, wherein the second receive electronics comprises a diode resistor divider. 前記第３の受信電子機器は、前記減衰された入力電圧信号を、前記アナログデジタル変換器のための適切な電圧範囲に電圧シフトするように構成される、請求項８に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 8, wherein the third receive electronics is configured to voltage shift the attenuated input voltage signal to a suitable voltage range for the analog-to-digital converter. 送信駆動電子機器は、送信専用ヒストトリプシ駆動システムを含む既存のヒストトリプシシステムに後付けされるように構成された別個の回路構成基板を備える、請求項８に記載の送受信駆動電子機器。 The transmit/receive driving electronics of claim 8, wherein the transmit driving electronics comprises a separate circuit configuration board configured to be retrofitted to an existing Histotripsy system, including a transmit-only Histotripsy driving system. 前記送信駆動電子機器は、前記送信専用ヒストトリプシ駆動システムに並列に追加され、送信専用電子機器に影響を与えることなく、信号を受動的に受信するように構成される、請求項１４に記載の送受信駆動電子機器。 The transmit/receive drive electronics of claim 14, wherein the transmit drive electronics are added in parallel to the transmit-only histotripsy drive system and are configured to passively receive signals without affecting the transmit-only electronics. 前記送信された１つまたは複数のヒストトリプシパルス、受信された入力電圧信号、および前記ＡＤＣ変換の時間クロックを同期させて、各ヒストトリプシパルス送信後に適切な時間ウィンドウを取得するようにさらに構成される、請求項８に記載の送受信駆動電子機器。 The transmit/receive driving electronics of claim 8, further configured to synchronize the time clocks of the transmitted one or more histotripsipulses, the received input voltage signal, and the ADC conversion to obtain an appropriate time window after each histotripsipulse transmission. 前記アナログデジタル変換器に結合され、単一のクロックを用いて前記送受信駆動電子機器の送受信動作を制御するように構成された、１つまたは複数のフィールドプログラマブルゲートアレイ（ＦＰＧＡ）基板をさらに備える、請求項８に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 8, further comprising one or more field programmable gate array (FPGA) boards coupled to the analog-to-digital converter and configured to control the transmit/receive operation of the transmit/receive driver electronics using a single clock. 前記１つまたは複数のＦＰＧＡは、受信信号のデータ負荷を低減するように構成されたソフトウェアまたはファームウェアを含む、請求項１７に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 17, wherein the one or more FPGAs include software or firmware configured to reduce the data load of a received signal. 前記１つまたは複数のＦＰＧＡは、前記アナログデジタル変換器からの入力データを人為的にダウンサンプルするように構成される、請求項１７に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 17, wherein the one or more FPGAs are configured to artificially downsample input data from the analog-to-digital converter. 前記１つまたは複数のＦＰＧＡは、信号対ノイズ比（ＳＮＲ）を高めるために、受信信号をオーバサンプルおよび平均化するように構成される、請求項１７に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 17, wherein the one or more FPGAs are configured to oversample and average received signals to increase signal-to-noise ratio (SNR). キャビテーション検出のために送受信ヒストトリプシシステムを使用する方法であって、
送信電子機器およびヒストトリプシ治療トランスデューサアレイを用いて、高電圧ヒストトリプシ治療パルスを標的組織に送信して、前記標的組織にキャビテーションを生成するステップと、
受信電子機器および前記ヒストトリプシ治療トランスデューサアレイを用いて、前記キャビテーションから低電圧音響キャビテーション放射信号を受信するステップと、
処置の進行を監視するために、前記受信した音響キャビテーション放射信号を処理するステップと
を備える、方法。 1. A method of using a transmit/receive histotripsy system for cavitation detection, comprising:
transmitting high voltage Histotripsy therapy pulses to a target tissue using transmit electronics and a Histotripsy therapy transducer array to generate cavitation in the target tissue;
receiving a low voltage acoustic cavitation radiation signal from said cavitation using receiving electronics and said histotripsy therapy transducer array;
and processing the received acoustic cavitation radiation signals to monitor progress of treatment. 前記送信されたパルスによって生成されるキャビテーションの３Ｄマップをリアルタイムで生成するステップをさらに含む、請求項２１に記載の方法。 22. The method of claim 21, further comprising generating in real time a 3D map of the cavitation produced by the transmitted pulses. 収差補正のために送受信ヒストトリプシシステムを使用する方法であって、
複数のトランスデューサ要素を有するヒストトリプシ治療トランスデューサアレイを用いて、ヒストトリプシ治療パルスを標的組織に送信して、前記標的組織にキャビテーションを生成するステップと、
前記ヒストトリプシ治療トランスデューサアレイを用いて、前記キャビテーションから音響キャビテーション放射信号を受信するステップと、
前記受信した音響キャビテーション放射信号に基づいて、前記キャビテーションから超音波トランスデューサアレイの各トランスデューサ要素までの移動時間を計算するステップと、
後続のヒストトリプシ治療パルスが、前記標的組織に同時に到着するように、前記計算された移動時間に基づいて、前記複数のトランスデューサ要素のうちの少なくとも１つのトランスデューサ要素のための送信時間遅延を調整するステップと
を備える、方法。 1. A method of using a transmit/receive histotripsy system for aberration correction, comprising the steps of:
transmitting a Histotripsy therapy pulse to a target tissue to generate cavitation in the target tissue using a Histotripsy therapy transducer array having a plurality of transducer elements;
receiving an acoustic cavitation radiation signal from the cavitation using the histotripsy therapy transducer array;
calculating a travel time from the cavitation to each transducer element of an ultrasonic transducer array based on the received acoustic cavitation radiation signals;
and adjusting a transmit time delay for at least one transducer element of the plurality of transducer elements based on the calculated travel time such that subsequent histotripsy therapy pulses arrive at the target tissue simultaneously. 前記移動時間を計算するステップは、前記音響キャビテーション放射にエンコードされた情報を使用するステップを含む、請求項２３に記載の方法。 24. The method of claim 23, wherein calculating the travel time includes using information encoded in the acoustic cavitation radiation. 前記情報は、キャビテーション膨張から生成される前記音響キャビテーション放射の開始時間を備える、請求項２４に記載の方法。 25. The method of claim 24, wherein the information comprises a start time of the acoustic cavitation radiation generated from a cavitation expansion. 前記情報は、キャビテーション崩壊から生成される前記音響キャビテーション放射の開始時間を備える、請求項２４に記載の方法。 25. The method of claim 24, wherein the information comprises a start time of the acoustic cavitation radiation generated from cavitation collapse. 前記情報は、キャビテーション崩壊からのピーク時間を備える、請求項２４に記載の方法。 25. The method of claim 24, wherein the information comprises a peak time from cavitation collapse. 既存の送信専用ヒストトリプシシステムの１つまたは複数のトランスデューサ要素に後付けされるように構成された受信駆動回路であって、
第１のトランスデューサ要素に電気的に結合されるように構成された分圧器であって、前記第１のトランスデューサ要素によって受信された電圧信号を減衰するように構成された、分圧器と、
前記分圧器に電気的に結合されたダイオード抵抗分圧器であって、所定の電圧を超える信号を圧縮するために、非線形減衰を提供するように構成され、前記受信された信号をアナログデジタル変換器にＡＣ結合するようにさらに構成された、ダイオード抵抗分圧器と
を備える、受信駆動回路。 1. A receive driver circuit configured to be retrofitted to one or more transducer elements of an existing transmit-only histotripsy system, comprising:
a voltage divider configured to be electrically coupled to a first transducer element, the voltage divider configured to attenuate a voltage signal received by the first transducer element;
a diode resistor divider electrically coupled to the voltage divider, the diode resistor divider configured to provide nonlinear attenuation to compress signals above a predetermined voltage, and further configured to AC couple the received signal to an analog-to-digital converter. 前記分圧器および前記ダイオード抵抗分圧器は、第１の回路構成基板に配置されるように構成され、別個の第２の回路構成基板に配置された高電圧ヒストトリプシ駆動電子機器に電気的に結合されるように構成される、請求項２８に記載の受信駆動回路。 The receiver driver circuit of claim 28, wherein the voltage divider and the diode resistor divider are configured to be disposed on a first circuit board and are configured to be electrically coupled to high voltage histotripsy drive electronics disposed on a separate second circuit board. 前記受信駆動回路および高電圧ヒストトリプシ駆動電子機器は、単一の回路構成基板に配置される、請求項２８に記載の受信駆動回路。 The receiver driver circuit of claim 28, wherein the receiver driver circuit and the high voltage histotripsy driver electronics are disposed on a single circuit configuration board. 送受信ヒストトリプシシステムであって、
トランスデューサ要素と、
前記トランスデューサ要素に結合され、ヒストトリプシパルスを前記トランスデューサ要素に供給するように構成された送信電子機器と、
前記トランスデューサ要素に結合された非線形コンプレッサ受信電子機器であって、第１の電圧信号を第１の減衰で圧縮するように構成され、第２の電圧信号を第２の減衰で圧縮するようにさらに構成され、前記第１の電圧信号は、前記第２の電圧信号よりも高く、前記第１の減衰は、前記第２の減衰よりも高い、非線形コンプレッサ受信電子機器と
を備える、送受信ヒストトリプシシステム。 A transmission and reception histotripsy system, comprising:
A transducer element;
transmit electronics coupled to the transducer elements and configured to provide histotripsy pulses to the transducer elements;
and non-linear compressor receive electronics coupled to the transducer element, the non-linear compressor receive electronics configured to compress a first voltage signal with a first attenuation and further configured to compress a second voltage signal with a second attenuation, the first voltage signal being higher than the second voltage signal, the first attenuation being higher than the second attenuation. ヒストトリプシシステム用の送受信駆動電子機器であって、
トランスデューサ要素と、
前記トランスデューサ要素に電気的に結合された２次変圧器コイルと、
前記２次変圧器コイルに隣接して配置された１次変圧器コイルであって、前記２次変圧器コイルを介して前記トランスデューサ要素において超音波パルスを生成するように構成された、１次変圧器コイルと、
前記２次変圧器コイルに隣接して配置された第３の変圧器コイルであって、前記トランスデューサ要素によって受信された電圧信号を、所定量減衰させるように構成された、第３の変圧器コイルと
を備える、送受信駆動電子機器。 A transmitter/receiver driver electronics for a Histotripsy system, comprising:
A transducer element;
a secondary transformer coil electrically coupled to the transducer element;
a primary transformer coil disposed adjacent to the secondary transformer coil and configured to generate ultrasonic pulses at the transducer elements via the secondary transformer coil;
a third transformer coil disposed adjacent to the secondary transformer coil, the third transformer coil configured to attenuate a voltage signal received by the transducer element by a predetermined amount. 前記第３の変圧器コイルは、前記受信された電圧信号を、９０～９９％減衰させるように構成される、請求項３２に記載の送受信駆動電子機器。 The transceiver driver electronic device of claim 32, wherein the third transformer coil is configured to attenuate the received voltage signal by 90 to 99%. 前記第３の変圧器コイルは、前記２次変圧器コイルよりも約７～１０倍少ない巻線で巻かれる、請求項３３に記載の送受信駆動電子機器。 The transceiver driver electronic device of claim 33, wherein the third transformer coil is wound with approximately 7 to 10 times fewer turns than the secondary transformer coil. 前記第３の変圧器コイルは、超音波パルスの送信中に飽和するように構成される、請求項３２に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 32, wherein the third transformer coil is configured to saturate during transmission of an ultrasonic pulse. 前記第３の変圧器コイルは、超音波パルスの送信中に飽和するように構成されるように、特別に選択されたコア材料およびサイズを有する信号変圧器に結合される、請求項３５に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 35, wherein the third transformer coil is coupled to a signal transformer having a specially selected core material and size so as to be configured to saturate during transmission of an ultrasonic pulse. ヒストトリプシシステムの送受信駆動電子機器であって、
超音波トランスデューサアレイと、
前記超音波トランスデューサアレイに結合され、１つまたは複数のヒストトリプシパルスを送信して、標的組織にキャビテーションを生成するように構成された送信電子機器と、
前記キャビテーションから音響キャビテーション放射を受信するように構成された受信電子機器と、
前記１つまたは複数のヒストトリプシパルスの送信中に、前記送信電子機器のみを有効化するように構成された送受信スイッチであって、受信信号を減衰させることなく送信信号を遮断するために、前記１つまたは複数のヒストトリプシパルスの送信後、所定の時間において、前記受信電子機器のみを有効化するようにさらに構成された、送受信スイッチと
を備える、送受信駆動電子機器。 A transmitter/receiver driving electronic device for a Histotripsy system, comprising:
an ultrasonic transducer array;
transmit electronics coupled to the ultrasound transducer array and configured to transmit one or more histotripsy pulses to generate cavitation in a target tissue;
receiving electronics configured to receive acoustic cavitation radiation from the cavitation;
a transmit/receive switch configured to enable only the transmit electronics during transmission of the one or more Histotripsy-pulses, and further configured to enable only the receive electronics at a predetermined time after transmission of the one or more Histotripsy-pulses to block a transmit signal without attenuating a receive signal. 前記受信電子機器の受信感度を最大化するために、その振幅に基づいて前記受信信号の選択された部分を増幅または減衰するために、異なる線形利得が、前記送受信スイッチに続く、請求項３７に記載の送受信駆動電子機器。 The transmit/receive driver electronics of claim 37, wherein different linear gains follow the transmit/receive switch to amplify or attenuate selected portions of the receive signal based on its amplitude to maximize the receive sensitivity of the receive electronics.
JP2023513613A 2020-08-27 2021-08-27 Ultrasonic transducer with transmitting and receiving functions for histotripsy Pending JP2023540482A (en)

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