JPS61186308A - Composition for oral cavity - Google Patents
Composition for oral cavityInfo
- Publication number
- JPS61186308A JPS61186308A JP2608185A JP2608185A JPS61186308A JP S61186308 A JPS61186308 A JP S61186308A JP 2608185 A JP2608185 A JP 2608185A JP 2608185 A JP2608185 A JP 2608185A JP S61186308 A JPS61186308 A JP S61186308A
- Authority
- JP
- Japan
- Prior art keywords
- aluminum lactate
- composition
- ascorbic acid
- oral
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 210000000214 mouth Anatomy 0.000 title abstract description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 46
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 claims abstract description 40
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 23
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 23
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 23
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 159000000000 sodium salts Chemical class 0.000 claims description 10
- 239000000606 toothpaste Substances 0.000 abstract description 17
- 229940034610 toothpaste Drugs 0.000 abstract description 16
- 208000028169 periodontal disease Diseases 0.000 abstract description 10
- 235000019606 astringent taste Nutrition 0.000 abstract description 5
- 235000010378 sodium ascorbate Nutrition 0.000 abstract description 4
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 abstract description 4
- 229960005055 sodium ascorbate Drugs 0.000 abstract description 4
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 210000004195 gingiva Anatomy 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 102000001554 Hemoglobins Human genes 0.000 description 10
- 108010054147 Hemoglobins Proteins 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 7
- 238000007796 conventional method Methods 0.000 description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 201000001245 periodontitis Diseases 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 208000025157 Oral disease Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 229960000686 benzalkonium chloride Drugs 0.000 description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 208000030194 mouth disease Diseases 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 229940085605 saccharin sodium Drugs 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 2
- 229910000393 dicalcium diphosphate Inorganic materials 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 239000002324 mouth wash Substances 0.000 description 2
- 229940051866 mouthwash Drugs 0.000 description 2
- 235000015927 pasta Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- -1 Polyoxyethylene monostearate Polymers 0.000 description 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
- 208000014151 Stomatognathic disease Diseases 0.000 description 1
- 208000026062 Tissue disease Diseases 0.000 description 1
- 208000008312 Tooth Loss Diseases 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
褒吸Δ立黙
本発明は、口腔用組成物に関し、さらに詳しくは、歯肉
組織および口腔粘膜に対する乳酸アルミニウムの収れん
作用により、口腔内疾患、特に歯槽膿漏の治療等に好ま
しい効果を与える乳酸アルミニウムを含有する口腔用組
成物に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a composition for oral cavity, and more specifically, the astringent action of aluminum lactate on gingival tissue and oral mucosa can be used to treat oral diseases, especially pyorrhea, etc. The present invention relates to an oral composition containing aluminum lactate that has a favorable effect on the oral cavity.
従来技術
一般に、歯科領域における二人疾患には、う蝕と歯周組
織疾患とがある。このうち歯周疾患は、その罹患状況お
よび歯牙喪失状態についての報告、並びに我が国の歯科
疾患実態調査報告等からも明らかなごとく、う蝕に匹敵
するほど高い罹患率を示しており、さらに歯牙に対する
影智もきわめて大きい。かかる歯周疾患は、いくつかの
要因が複合して生ずるものであり、さらにその発生にあ
たっては該疾患に対しての抵抗性に関する個人差なども
関連性を有し、極めて複雑な因子により発現するが、こ
れら各種の要因の中で最も重要なものは局部的因子であ
る口腔内の清浄度であると考えられている。BACKGROUND OF THE INVENTION In general, two diseases in the dental field are dental caries and periodontal tissue diseases. Of these, periodontal disease has a morbidity rate comparable to that of dental caries, as is clear from reports on its morbidity and tooth loss status, as well as reports on the actual state of dental diseases in Japan. Kagechi is also extremely large. Such periodontal diseases are caused by a combination of several factors, and their occurrence is also related to individual differences in resistance to the disease, and is caused by extremely complex factors. However, the most important factor among these various factors is considered to be the local factor, the cleanliness of the oral cavity.
すなわち、該歯周疾患の機構は、まず歯肉の乳頭部及び
辺縁部の充面が起って腫脹などを生じ、歯肉表面が腫れ
るような状態を呈し、軟らかく出血しやすくなり、さら
に歯肉の炎症が拡大して、ついには歯槽膿漏に至る経路
をたどるのが普通である。従って、歯周疾患の予防には
、その初期症状である単純性乳頭、辺縁性歯肉炎の発生
を阻止することが肝要であって、このために日常生活に
おいては、歯口清掃を適切に行なうことが大切である。In other words, the mechanism of periodontal disease is that the gingival papilla and margins first become full and swell, causing the gingival surface to become swollen, become soft and easily bleed, and then become soft and bleed easily. Usually, the inflammation spreads and eventually leads to alveolar pyorrhea. Therefore, in order to prevent periodontal disease, it is important to prevent the occurrence of the early symptoms of periodontal disease, such as simple papillary and marginal gingivitis. It is important to do it.
かかる目的のため、歯周疾患の予防に効果のある口腔用
組成物を用いて歯口清掃を行なうことは有効かつ合理的
なことであり、このような用途に適した種々の薬剤を配
合した口腔用組成物が提案されている。For this purpose, it is effective and rational to perform oral cleaning using oral compositions that are effective in preventing periodontal diseases, and it is effective and rational to perform oral cleaning using oral compositions that are effective in preventing periodontal diseases. Oral compositions have been proposed.
これら口腔用組成物に含有される薬剤のうち、乳酸アル
ミニウムあるいはアルミニウムアラントイネートなどの
アルミニウム化合物は、口腔内疾患、特に歯肉の引き締
め、あるいは、歯槽膿漏等の歯周疾患の予防および治療
に効果的であることが広く認められており、歯周疾患の
予防、治療を目的として、乳酸アルミニウムを配合した
歯磨等が既に知られている。Among the drugs contained in these oral compositions, aluminum compounds such as aluminum lactate or aluminum allantoinate are effective for the prevention and treatment of oral diseases, especially gingival tightening, and periodontal diseases such as pyorrhea. It is widely acknowledged to be effective, and toothpastes containing aluminum lactate are already known for the purpose of preventing and treating periodontal diseases.
しかしながら、乳酸アルミニウムの歯肉に対する収れん
作用は十分ではなく、乳酸アルミニウムを用いてアルミ
ニウムアラントイネートと同等の収れん性を得るには、
約１０倍量もの配合が必要である。However, the astringent effect of aluminum lactate on the gingiva is not sufficient, and in order to obtain the same astringency as aluminum allantoinate using aluminum lactate,
It is necessary to mix about 10 times the amount.
発明の概要
本発明者らは、かかる口腔用組成物中の乳酸アルミニウ
ムの歯肉に対する収れん性を強化すべく鋭意検討を行な
った結果、乳酸アルミニウムを含有する口腔用組成物に
アスコルビン酸またはそのナトリウム塩を添加すると意
外にも乳酸アルミニウムの収れん性が著しく増強される
ことを見出し本発明を完成するに至った。Summary of the Invention The present inventors have conducted intensive studies to enhance the astringent properties of aluminum lactate in oral compositions for the gingiva, and have found that ascorbic acid or its sodium salt is added to oral compositions containing aluminum lactate. The present inventors have unexpectedly discovered that the astringency of aluminum lactate is significantly enhanced when aluminum lactate is added, and have completed the present invention.
すなわち、本発明は、乳酸アルミニウムを含有する口腔
用組成物において、アスコルビン酸またはそのナトリウ
ム塩を配合したことを特徴とする口腔用組成物を提供す
るものである。That is, the present invention provides an oral composition containing aluminum lactate, which is characterized in that it contains ascorbic acid or its sodium salt.
したがって、本発明によれば、乳酸アルミニウムの歯肉
における収れん性を増強した優れた口腔用組成物が得ら
れ、その使用により口腔内疾患、特に歯槽膿漏の治療等
に好ましい効果を示す。Therefore, according to the present invention, an excellent oral composition in which the astringency of aluminum lactate in the gums is enhanced is obtained, and its use shows favorable effects in the treatment of oral diseases, particularly alveolar pyorrhea.
乳酸アルミニウムの収れん性を増強させるものとしては
他にラウリル硫酸ナトリウム、塩化ベンザルコニウム等
もあるが、これらはいずれもそれ自身収れん作用を有し
、乳酸アルミニウムとの組み合わせによる効果は単なる
相加効果でしかない。There are other substances that enhance the astringency of aluminum lactate, such as sodium lauryl sulfate and benzalkonium chloride, but these all have astringent effects themselves, and the effect when combined with aluminum lactate is merely an additive effect. It's just that.
これに反して、アスコルビン酸またはそのナトリウム塩
はそれ自身に全く収れん作用がなく、従ってこれらと乳
酸アルミニウムとの組み合わせにより全く新たな収れん
活性増強効果が生じたものである。On the other hand, ascorbic acid or its sodium salt itself has no astringent action at all, and therefore, the combination of these and aluminum lactate produces a completely new astringent activity-enhancing effect.
発明の詳説
つぎに、本発明組成物にて配合されるアスコルビン酸ま
たはそのナトリウム塩、およびこれら以外の添加剤につ
いて、これら添加剤が乳酸アルミニウムの歯肉収れん活
性を増強する効果について試験した結果を第１表に示す
。DETAILED DESCRIPTION OF THE INVENTION Next, we will present the results of tests on ascorbic acid or its sodium salt and other additives blended in the composition of the present invention to determine their effect on enhancing the gingival astringent activity of aluminum lactate. It is shown in Table 1.
各添加剤の収れん活性は奥田ら（薬学雑誌牲、１１４３
（１９７６） ；９７．１２６７（１９７？））の方法
に従い、ヘモグロビンに対する吸着作用を用いて下記の
ように測定した。The astringent activity of each additive was determined by Okuda et al.
(1976) ; 97.1267 (197?)), and was measured as follows using the adsorption effect on hemoglobin.
ヘモグロビン溶液の調製：
クエン酸ナトリウムを添加したヒト新鮮血に水を加えて
溶血液を得、５７８ｎｍの吸光度が０．９５〜１．０５
になるよう調製した。Preparation of hemoglobin solution: Add water to fresh human blood to which sodium citrate has been added to obtain hemolysate, and the absorbance at 578 nm is 0.95-1.05.
It was prepared so that
ヘモグロビン吸着作用の測定：
ヘモグロビン溶液２ ｘＱ、乳酸アルミニウム水溶液１
ｍＱ、試料溶液１１（２（アスコルビン酸等）、０．
２Ｍリン酸緩衝液（ｐＨ６，０） １ ｍＱをまぜて攪
拌し、１時間放置後１２．０００ｒＮ＋ ｌ Ｏ分間遠
心分離し、上清の吸光度を５７８ｎｍで測定した。該吸
光度と、ヘモグロビン無添加における同様の吸光度との
差をΔＯＤｓとする。乳酸アルミニウムおよび試料が無
添加の時の吸光度（ＯＤｃ）に対する前記ΔＯＤｓの割
合を試料添加時の上清ヘモグロビン量（Ｈｓ）とした。Measurement of hemoglobin adsorption effect: Hemoglobin solution 2 x Q, aluminum lactate aqueous solution 1
mQ, sample solution 11 (2 (ascorbic acid, etc.), 0.
1 mQ of 2M phosphate buffer (pH 6,0) was mixed and stirred, left to stand for 1 hour, centrifuged for 12,000 rN + 1 O, and the absorbance of the supernatant was measured at 578 nm. The difference between this absorbance and a similar absorbance without the addition of hemoglobin is defined as ΔODs. The ratio of ΔODs to the absorbance (ODc) when aluminum lactate and the sample were not added was taken as the amount of supernatant hemoglobin (Hs) when the sample was added.
上記において試料を精製水にかえた以外、全く同様にし
て乳酸アルミニウム単独の場合の上清ヘモグロビン量Ｈ
Ｌ（ＨＬ＝Δ０ＤＬ１０ＤＣＸＩ ＯＯ）を得た。Supernatant hemoglobin amount H when using aluminum lactate alone in the same manner as above except that the sample was changed to purified water
L (HL=Δ0DL10DCXIOO) was obtained.
収れん活性の算出：
収れん活性の増強度は、乳酸アルミニウムのヘモグロビ
ン吸着量（１０Ｇ−ＨＬ）を１００％とし、これに対す
る各試料のヘモグロビン吸着量（１００−Ｈｓ）を％で
表わした。Calculation of astringent activity: The degree of enhancement of astringent activity was expressed as a percentage of the hemoglobin adsorption amount (100-Hs) of each sample relative to the hemoglobin adsorption amount (10G-HL) of aluminum lactate as 100%.
増強度（％）＝１００−Ｈ８×１ｏ。Enhancement degree (%) = 100-H8 x 1o.
０Ｏ−ＨＬ
＊・・・乳酸アルミニウム１．０％即ちヘモグロビン吸
着量５３％に対しての増強度を示す。0O-HL *...Indicates the degree of enhancement with respect to aluminum lactate 1.0%, ie, hemoglobin adsorption amount 53%.
第１表より明らかなごとく、増強度が１００％以上を示
すものにはアスコルビン酸またはそのナトリウム塩、ラ
ウリル硫酸ナトリウム、塩化ベンザルコニウム等がある
が、このうちラウリル硫酸ナトリウムおよび塩化ベンザ
ルコニウムは、単独でも１００％を超えており、相加効
果を示すにすぎない。これらに反し、アスコルビン酸ま
たはそのナトリウム塩は単独では収れん作用がほとんど
ないにもかかられらず、乳酸アルミニウムとの組み合わ
せによって、収れん活性の増強効果が発現する。As is clear from Table 1, ascorbic acid or its sodium salt, sodium lauryl sulfate, benzalkonium chloride, etc. exhibit an enhancement degree of 100% or more, but among these, sodium lauryl sulfate and benzalkonium chloride are , alone exceeds 100%, indicating only an additive effect. On the other hand, ascorbic acid or its sodium salt alone has almost no astringent action, but when combined with aluminum lactate, an astringent activity-enhancing effect is expressed.
しかして、本発明の口腔内組成物には、アスコルビン酸
またはそのナトリウム塩が用いられる。Therefore, ascorbic acid or its sodium salt is used in the oral composition of the present invention.
また、これらは、混合して配合してもよい。Moreover, these may be mixed and blended.
本発明口腔用組成物における乳酸アルミニウムの含有量
は練歯磨組成物の場合には、組成物全体に対してＱ、１
〜２重量％であるのが好ましい。乳酸アルミニウムの含
有量が０．１重量％未満では充分な収れん効果が発揮さ
れず、一方、２重量％を超えると使用時の味が悪化し、
使用感が耐えがたく好ましくない。In the case of a toothpaste composition, the content of aluminum lactate in the oral composition of the present invention is Q, 1
Preferably it is 2% by weight. If the content of aluminum lactate is less than 0.1% by weight, a sufficient astringent effect will not be exhibited, while if it exceeds 2% by weight, the taste during use will deteriorate,
The feeling of use is unbearable and undesirable.
アスコルビン酸またはそのナトリウム塩の配合量は、乳
酸アルミニウムの含有量に対して３〜５０重量％である
のが好ましい。かかる配合量が３重量％未満では、収れ
ん効果は充分でなく、一方、５０重量％を超えると粘度
等の性状安定性に対して問題が生じ好ましくない。The blending amount of ascorbic acid or its sodium salt is preferably 3 to 50% by weight based on the content of aluminum lactate. If the blending amount is less than 3% by weight, the astringent effect will not be sufficient, while if it exceeds 50% by weight, problems will occur with respect to property stability such as viscosity, which is not preferable.
本発明の口腔用組成物は、その種類に応じて、通常、口
腔用組成物に使用される公知の他の成分をいずれも使用
することができる。例えば、練歯磨の場合には、湿潤剤
として、グリセリン、ソルビトールなどが用いられる。The oral composition of the present invention may contain any other known components that are normally used in oral compositions, depending on the type. For example, in the case of toothpaste, glycerin, sorbitol, etc. are used as humectants.
その配合量は、製品の形状に応じて種々変化し、特に制
限されるものではない。さらに、研磨剤、粘結剤、発泡
剤、香料、甘味料など通常、歯磨に使用されるものを通
常の使用割合で配合してよい。The blending amount varies depending on the shape of the product and is not particularly limited. Furthermore, abrasives, binders, foaming agents, fragrances, sweeteners, and other substances commonly used in toothpaste may be blended in the usual proportions.
したがって、本発明口腔用組成物は、練歯磨あるいは水
分を配合しない粉歯磨とすることもでき得るほか、含囃
剤、チューインガム、錠剤、トローチなどの製品とする
こともできる。これらの場合、それぞれ製品基材は、通
常の有効基剤が用いられてよく、これらを常法に従い、
処理して、口腔用組成物を得る。Therefore, the oral composition of the present invention can be used as a toothpaste or a powdered toothpaste that does not contain water, and can also be used as a product such as a mouthwash, chewing gum, tablet, or troche. In these cases, a usual effective base may be used as the product base, and these are processed according to a conventional method.
Processing yields an oral composition.
実施例
つぎに、本発明を実施例により、さらに詳しく説明する
。なお、％とあるは、全て重量％を意味する。EXAMPLES Next, the present invention will be explained in more detail with reference to examples. In addition, all % means weight %.
実施例１
つぎの処方により、常法に従って乳酸アルミニウムおよ
びアスコルビン酸を配合した練歯磨を調製した。Example 1 A toothpaste containing aluminum lactate and ascorbic acid was prepared according to the following recipe according to a conventional method.
成 分 配合量（％）炭酸カル
シウム ３５０ソルビトール
３０．０グリセリン
８．０カラギーナン ２
．０サツカリンナトリウム ０．１香料
１．０乳酸アルミニ
ウム １．０アスコルビン酸
０．４ラウリル硫酸ナトリウム
１２水 １００％
に調整一方、対照として上記組成においてアスコルビン
酸と乳酸アルミニウムの代わりに同量の水を配合した練
歯磨を調製する。Ingredients Amount (%) Calcium carbonate 350 Sorbitol
30.0 Glycerin
8.0 carrageenan 2
．． 0 Saccharin sodium 0.1 Fragrance 1.0 Aluminum lactate 1.0 Ascorbic acid
0.4 Sodium lauryl sulfate
12 water 100%
On the other hand, as a control, a toothpaste containing the same amount of water in place of ascorbic acid and aluminum lactate in the above composition was prepared.
得られた歯磨について試験例と同様にして収れん活性を
測定し、アスコルビン酸の増強度（％）を求めたところ
１８５％と大きな増強効果が認められた。The astringent activity of the obtained toothpaste was measured in the same manner as in the test example, and the degree of enhancement (%) of ascorbic acid was determined, and a large enhancement effect of 185% was observed.
比較例１
アスコルビン酸の代わりに同量の水を用いた以外、実施
例１と同様にして練歯磨を調製した。増強度を実施例１
と同様にして測定したところ、１３４％であった。Comparative Example 1 A toothpaste was prepared in the same manner as in Example 1, except that the same amount of water was used instead of ascorbic acid. Example 1 of enhancement degree
When measured in the same manner as above, it was 134%.
実施例２ つぎの処方により、常法に従って練歯磨を製造した。Example 2 A toothpaste was manufactured according to a conventional method using the following formulation.
成 分 配合量（％）第ニリン酸
カルシウム ４５，０ソルビトール
２５．０カラギーナン
１．０Ｎ−ラウロイルサルコシンナトリウム
０．５サツカリンナトリウム ０．１乳
酸アルミニウム ２．０アスコルビ
ン酸 １．０香料
０．９ラウリル硫酸ナトリウム
０．７水 １
００に調整得られた練歯磨の収れん活性の増強度を実施
例１と同様にして測定したところ、１５７％であった。Ingredients Amount (%) Calcium diphosphate 45,0 Sorbitol
25.0 carrageenan
1.0N-Lauroylsarcosine sodium
0.5 Saccharin sodium 0.1 Aluminum lactate 2.0 Ascorbic acid 1.0 Fragrance
0.9 Sodium lauryl sulfate
0.7 water 1
The degree of enhancement of the astringent activity of the obtained toothpaste was measured in the same manner as in Example 1, and was found to be 157%.
実施例３ つぎの処方により、常法に従って練歯磨を製造した。Example 3 A toothpaste was manufactured according to a conventional method using the following formulation.
成 分 配合量（％）第ニリン酸
カルシウム ４０．０ソルビトール
２０．０グリセリン
１０．０カラギーナン １
．０ラウリル硫酸ナトリウム １．２サツ
カリンナトリウム ０．２アスコルビン
酸 ０．０５乳酸アルミニウム
０．５香料
１．０水 １０
０％に調整得られた練歯磨の収れん活性の増強度を実施
例１と同様にして測定したところ、１６２％であった。Ingredients Amount (%) Calcium diphosphate 40.0 Sorbitol
20.0 Glycerin
10.0 carrageenan 1
．． 0 Sodium lauryl sulfate 1.2 Sodium saccharin 0.2 Ascorbic acid 0.05 Aluminum lactate
0.5 fragrance
1.0 water 10
The degree of enhancement of the astringent activity of the obtained toothpaste adjusted to 0% was measured in the same manner as in Example 1, and was found to be 162%.
実施例４
つぎの処方により、常法に従ってマウスウォッシュを製
造した。Example 4 A mouthwash was manufactured according to a conventional method using the following formulation.
成 分 配合量（％）エチルアル
コール ２５．０グリセリン
５．０アスコルビン酸
０．０３乳酸アルミニウム １
．０サツカリンナトリウム ０．０５香
料 １．０水
１００％に調整得られた練歯磨
の収れん活性の増強度を実施例１と同様にして測定した
ところ、１３７％であった。Ingredients Amount (%) Ethyl alcohol 25.0 Glycerin
5.0 ascorbic acid
0.03 aluminum lactate 1
．． 0 Saccharin Sodium 0.05 Flavor 1.0 Water
The degree of enhancement of astringent activity of the obtained toothpaste adjusted to 100% was measured in the same manner as in Example 1, and was found to be 137%.
実施例５ つぎの処方により、常法に従って水歯磨を製造した。Example 5 A water dentifrice was manufactured according to the conventional method using the following formulation.
成 分 配合１ｋ（％）ラウリ
ル硫酸ナトリウム ３エチルアルコール
５メチルセルロース
２サツカリンナトリウム ０．１アス
コルビン酸ナトリウム ０．０５乳酸アルミ
ニウム ０．１香料
０．３水
１００％に調整得られた練歯磨の収れん活性の増強
度を実施例１と同様にして測定したところ、１７３％で
あった。Ingredients: 1k (%) Sodium lauryl sulfate 3 Ethyl alcohol
5 methylcellulose
2 Sacchulin sodium 0.1 Sodium ascorbate 0.05 Aluminum lactate 0.1 Flavor
0.3 water
The degree of enhancement of astringent activity of the obtained toothpaste adjusted to 100% was measured in the same manner as in Example 1, and was found to be 173%.
実施例６
つぎの処方により、常法に従って口腔用パスタを製造し
た。Example 6 Oral pasta was produced according to the conventional method using the following recipe.
成 分 配合量（％）ポリオキシ
エチレン
モノステアレート ３ソルビタンモ
ノオレエート ２セチルアルコール
５プロピレングリコール １５
ヒドロキシエチル
セルロース ５サツカリンナト
リウム ０．２香料
０．３乳酸アルミニウム
１．５アスコルビン酸 ０．
４５水 １００％に調整
得られた口腔用パスタの収れん活性増強度は１７７％で
あった。Ingredients Amount (%) Polyoxyethylene monostearate 3 Sorbitan monooleate 2 Cetyl alcohol
5 Propylene glycol 15
Hydroxyethyl cellulose 5 Satucharin sodium 0.2 Fragrance
0.3 aluminum lactate
1.5 Ascorbic acid 0.
The degree of astringent activity enhancement of the obtained oral pasta adjusted to 100% water was 177%.
Claims (3)
て、アスコルビン酸またはそのナトリウム塩を配合した
ことを特徴とする口腔用組成物。(1) An oral composition containing aluminum lactate, which is characterized in that it contains ascorbic acid or its sodium salt.
て０．１〜２重量％である前記第１項の口腔用組成物。(2) The oral composition according to item 1 above, wherein the content of aluminum lactate is 0.1 to 2% by weight based on the total weight of the composition.
が、乳酸アルミニウムの含有量に対して３〜５０重量％
である前記第１項または第２項の口腔用組成物。(3) The blending amount of ascorbic acid or its sodium salt is 3 to 50% by weight based on the content of aluminum lactate.
The oral composition according to item 1 or 2 above.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2608185A JPH0635374B2 (en) | 1985-02-12 | 1985-02-12 | Oral composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2608185A JPH0635374B2 (en) | 1985-02-12 | 1985-02-12 | Oral composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61186308A true JPS61186308A (en) | 1986-08-20 |
| JPH0635374B2 JPH0635374B2 (en) | 1994-05-11 |
Family
ID=12183677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2608185A Expired - Lifetime JPH0635374B2 (en) | 1985-02-12 | 1985-02-12 | Oral composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0635374B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2633634A1 (en) * | 1988-07-01 | 1990-01-05 | Showa Denko Kk | ABRASIVE COMPOSITION AND METHOD FOR POLISHING A PLASTIC ARTICLE |
| JP2002302429A (en) * | 2001-04-03 | 2002-10-18 | Nippon Zettoc Co Ltd | Oral composition |
| JP2002335721A (en) * | 2001-05-23 | 2002-11-26 | Yanmar Agricult Equip Co Ltd | Planting part of rice transplanter |
| WO2010074025A1 (en) * | 2008-12-24 | 2010-07-01 | ライオン株式会社 | Dentifrice composition |
-
1985
- 1985-02-12 JP JP2608185A patent/JPH0635374B2/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2633634A1 (en) * | 1988-07-01 | 1990-01-05 | Showa Denko Kk | ABRASIVE COMPOSITION AND METHOD FOR POLISHING A PLASTIC ARTICLE |
| JP2002302429A (en) * | 2001-04-03 | 2002-10-18 | Nippon Zettoc Co Ltd | Oral composition |
| JP2002335721A (en) * | 2001-05-23 | 2002-11-26 | Yanmar Agricult Equip Co Ltd | Planting part of rice transplanter |
| WO2010074025A1 (en) * | 2008-12-24 | 2010-07-01 | ライオン株式会社 | Dentifrice composition |
| JP2014144989A (en) * | 2008-12-24 | 2014-08-14 | Lion Corp | Dentifrice composition, oral antiinflammatory agent and halitosis improvement agent |
| JP5589849B2 (en) * | 2008-12-24 | 2014-09-17 | ライオン株式会社 | Dentifrice composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0635374B2 (en) | 1994-05-11 |
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