JP2006271939A - Prefilled syringe - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a prefilled syringe capable of reliably discharging the contents stored in a plurality of storage chambers without being ventilated with the outside air and then discharging them, and easily manufacturing the outer cylinder.
SOLUTION: An outer cylinder 12 having a discharge portion 11, a plunger gasket 15 and a plurality of partitioning gaskets 16X, 16Y disposed therein, and a discharge chamber 18 adjacent to the discharge portion 11 side and a plurality of mixing portions are provided. A plurality of mixing chambers 19a and 19b in which components are stored are partitioned, and when the intermediate partition gasket 16Y reaches the mixing region L1, the mixing means 30 communicates between the plurality of mixing chambers 19a and 19b. When the front partition gasket 16X reaches the discharge region L2, the mixing passage 31 and the discharge passage 25 of the opening / closing means 20 communicating between the mixing storage chamber 19a and the discharge chamber 18 are provided. After the mixing channel 31 is opened, the discharge channel 25 is opened.
[Selection] Figure 1

Description

  In the present invention, a plurality of storage chambers are partitioned by a plurality of partitioning gaskets arranged in an outer cylinder, a plurality of mixed components that are mixed and discharged in use in these storage chambers, and dissolved and discharged in use. The present invention relates to a prefilled syringe suitable for isolating and containing a solid drug and a solution to be stored.

  Conventionally, in the case of injections and infusions for administering multiple components to patients, components that are prone to degradation or alteration at an early stage when mixed are stored separately and mixed immediately before use. For example, it is stored as a solid drug that is stable and easy to store for a long time, and is mixed with a solution or dispersion at the time of use to prepare an injection or infusion. Many are administered to patients.

  In order to facilitate the mixing operation at the time of use and prevent mistakes in preparation, the inside of the outer cylinder is divided into a plurality of storage chambers by partition gaskets, and a solid medicine or a chemical solution is stored in one storage chamber. A number of two-chambered prefilled syringes have been proposed in which a solution, a dispersion, other chemicals, and the like are housed in the housing chamber (see, for example, Patent Document 1 below).

  When these prefilled syringes are moved to a predetermined mixing area by pressing the plunger during use to partition the plurality of storage chambers, for example, both sides of the partitioning gasket are formed by vertical grooves provided in the outer cylinder. A flow path communicating between the storage chambers is formed, and the solution, dispersion liquid, chemical solution, or the like in one storage chamber can be transferred and mixed into the other storage chamber by this flow path. And if a plunger is further pressed after mixing, it is possible to discharge the liquid mixture obtained by mixing from a discharge part.

  However, in such a prefilled syringe, the mixing unit is operated by moving the partition gasket while discharging the gas in the storage chamber adjacent to the discharging unit with the discharging unit being opened at the time of mixing. The accommodation chamber adjacent to the outside and the outside are communicated with each other so as to be able to ventilate, and it is easy for outside air to enter the accommodation chamber, and the contained components are easily contacted with the outside air and easily deteriorated by bacteria, oxygen, and the like. Further, since a part of the storage chamber and the stored item at the tip of the discharge part can be easily discharged to the outside, the discharge amount is easily changed, and the mixing operation is troublesome.

  Therefore, in Patent Document 2 below, only gas is stored in a storage chamber adjacent to the discharge portion in the outer cylinder, and a plurality of stored items are separated into the storage chamber on the plunger side partitioned by the storage chamber and the seal stopper. It was housed in a separated state. Here, since the space between the internal storage chamber and the discharge portion is maintained in a closed state by the seal stopper at the time of mixing the storage material, the internal storage chamber is not communicated with the outside, and the storage material is not mixed during the mixing operation. Can be prevented from coming into contact with the outside air, and part of the contents can be prevented from being released to the outside.

Japanese Utility Model Publication No. 49-14465 JP-A-62-2357

  However, in such a prefilled syringe, there is provided a bypass for mixing that communicates between the internal storage chambers by moving a separation stopper disposed inside the outer cylinder to a predetermined mixing region in the outer cylinder. The discharge stopper is formed in a state where the seal stopper arranged on the discharge portion side reaches the discharge portion in the outer cylinder. Since the discharge channel must be formed independently of the mixing bypass, a plurality of channels must be provided in the outer cylinder, and the seal stopper is provided at the end of the outer cylinder. In order to open in the close position, the flow path had to be provided in the longitudinal direction and the radial direction at the end of the outer cylinder and in the vicinity thereof. Therefore, the outer cylinder has a complicated shape. For example, it takes time and effort to manufacture the outer cylinder, such as forming and connecting the cylindrical portion and the end of the outer cylinder as separate members.

  Therefore, the present invention is mainly used for mixed injection, and the contents in a plurality of storage chambers can be reliably mixed inside without being ventilated with the outside air and discharged, and the outer cylinder can be easily manufactured. It is an object to provide a prefilled syringe.

The invention according to claim 1 for solving the above-mentioned problems includes an outer cylinder having a discharge part, a gasket for a plunger disposed in a liquid-tight manner in the outer cylinder, the discharge part and the plunger in the outer cylinder. A plurality of partition gaskets disposed in a liquid-tight manner between the discharge gasket and the discharge chamber adjacent to the discharge portion by the plurality of partition gaskets, and adjacent to the plunger side from the discharge chamber. A prefilled syringe in which a plurality of mixing components are separated from each other and stored separately in the plurality of mixing chambers. There,
The plurality of partitioning gaskets include a front partitioning gasket for partitioning between the discharge chamber and the mixing storage chamber, and an intermediate partitioning gasket for partitioning between the plurality of mixing storage chambers,
A mixing means for opening a mixing channel communicating between the mixing chambers when the gasket for intermediate partition reaches the mixing region in the outer cylinder;
It has a through hole formed in the front partition gasket and a partition molding that is slidably disposed in the through hole, and the front partition gasket reaches a discharge area in the outer cylinder. Then, the partition gasket and the partition molding are relatively moved, and includes an opening / closing means for opening the discharge channel,
When the plurality of partitioning gaskets are moved by movement of the plunger gasket toward the discharge part, the mixing region and the discharge region are provided so that the discharge channel is opened after the mixing channel is opened. It is characterized by that.

  According to a second aspect of the present invention, in the first aspect of the present invention, the opening / closing means is configured such that the partitioning gasket moves relative to the partitioning molded body to open the discharge passage. And

  According to a third aspect of the present invention, in the first aspect of the present invention, the opening / closing means is configured such that the partition molding is relatively moved with respect to the partition gasket and the discharge passage is opened. And

  According to a fourth aspect of the present invention, in the invention according to the second or third aspect, the opening / closing means is configured such that one of the front partition gasket or the partition molding is the discharge portion side end portion of the outer cylinder. It is characterized in that the other is relatively moved by restricting the movement in contact with.

  The invention according to claim 5 is the invention according to any one of claims 1 to 4, wherein the mixing channel of the mixing means is provided between the front partition gasket and the intermediate partition gasket. A groove shape is formed on the inner surface of the outer cylinder.

  According to the first aspect of the present invention, when the intermediate partition gasket for partitioning the plurality of mixing chambers reaches the mixing region in the outer cylinder, the mixing channel communicating between the mixing chambers is provided. For a partition provided with a mixing means to be opened, a front partition gasket for partitioning a discharge chamber adjacent to the discharge portion and an internal mixing chamber, and a slidable arrangement in the through hole An opening and closing means for opening the discharge flow path by relative movement of the partition gasket and the partition molded body when the front partition gasket reaches the discharge region in the outer cylinder. Since the mixing region and the discharge region are provided so that the discharge channel of the opening / closing unit is opened after the mixing channel of the mixing unit is opened, the mixing channel can be opened with the discharge channel closed. , The contents of multiple mixing chambers Or by contacting a portion of the contained object can perform mixing operation without releasing to the outside. In addition, when the front partition gasket reaches the discharge area of the outer cylinder, the partition molding and the inside of the through hole can move relative to each other to form a discharge flow path. There is no need to form the outer cylinder, and the outer cylinder can be made into a simple shape, and the outer cylinder can be easily manufactured.

  According to the second aspect of the present invention, the opening / closing means is configured such that the partition gasket moves relative to the partition molded body and the discharge channel is opened, so that the front partition gasket is placed in the discharge region of the outer cylinder. If it reaches, the through hole can be moved relative to the partition molding to form a discharge flow path, so that it is not necessary to form a discharge flow path in the outer cylinder, and the outer cylinder is made into a simple shape. The outer cylinder can be easily manufactured.

  According to the third aspect of the present invention, the opening / closing means moves the partition molded body relative to the partition gasket and opens the discharge channel, so that the front partition gasket is placed in the discharge region of the outer cylinder. If it arrives, the molded body for partitioning can move relative to the through-hole to form the discharge flow path, so that it is not necessary to form the discharge flow path in the outer cylinder, and the outer cylinder has a simple shape. The outer cylinder can be easily manufactured.

  According to the fourth aspect of the present invention, the opening / closing means is configured such that one of the front partition gasket or the partition molding is in contact with the discharge portion side end of the outer cylinder and the movement is restricted, so that the other is relatively Since it moves, it is not necessary to provide a special shape inside the outer cylinder in order to relatively move the front partition gasket and the partition molding, and the outer cylinder can be made simpler.

  According to the invention described in claim 5, since the mixing flow path of the mixing means is formed in a groove shape on the inner surface of the outer cylinder between the front partition gasket and the intermediate partition gasket, By simply setting the position of the groove-shaped mixing channel, the operation of opening the discharge channel after the mixing channel is opened can be easily and reliably performed with a simple configuration.

Embodiments of the present invention will be described below.
1 to 3 show this embodiment.
In the figure, reference numeral 10 denotes a three-chamber prefilled syringe. The prefilled syringe 10 is connected to the outer cylinder 12 having the discharge portion 11 on the front end side, the plunger 14 disposed on the rear end side of the outer cylinder 12, and the front end side of the plunger 14, and is liquid-tight in the outer cylinder 12. The plunger gasket 15 slidably disposed, and the front partition disposed in a liquid-tight and slidable manner on the discharge portion 11 side between the plunger gasket 15 and the discharge portion 11 in the outer cylinder 12. Gasket 16X, and an intermediate partition gasket 16Y disposed between the plunger gasket 15 and the front partition gasket 16X in a liquid-tight and slidable manner.
A discharge port 11c and a luer lock structure 11b are provided on the end surface 11a of the discharge unit 11, and the tip of the discharge port 11c is sealed with a tip cap 11d as a closing means.

  Here, a discharge chamber 18 is defined between the front partition gasket 16X and the discharge portion 11, and a front mixing storage chamber 19a is defined between the front partition gasket 16X and the intermediate partition gasket 16Y. A rear mixing storage chamber 19b is defined between the intermediate partition gasket 16Y and the plunger gasket 15.

  A gas such as air or nitrogen gas is accommodated in the discharge chamber 18, and the front mixing storage chamber 19a and the rear mixing storage chamber 19b are separated from each other at the time of manufacture and storage, and are mixed and discharged at the time of use. Various mixed components such as various gases, liquids, and powders are accommodated. This mixed component may be a chemical solution that is discharged from the prefilled syringe 10 and directly administered to the human body, or a chemical solution that is once discharged to another container and then administered to the human body. The front mixing storage chamber 19a stores, for example, a solid or liquid dissolved component such as a lyophilized drug, and the rear mixing storage chamber 19b stores a dissolution liquid that dissolves the dissolved component.

  In this prefilled syringe 10, the front partition gasket 16X is moved to the discharge portion 11 side by a predetermined amount, so that the discharge chamber 18 on the discharge portion 11 side of the front partition gasket 16X and the front mixing storage chamber 19a. Opening / closing means 20 for communicating with each other is provided in the front partition gasket 16X, and mixing means 30 capable of communicating between the front mixing storage chamber 19a and the rear mixing storage chamber 19b is provided.

  The mixing unit 30 includes a mixing channel 31 provided in the outer cylinder 12, and is located on the plunger 14 side of the front partition gasket 16X including the opening / closing unit 20 and between the intermediate partition gasket 16Y. Further, a part of the outer cylinder 12 is bulged outwardly to form a groove extending in the longitudinal direction on the inner surface of the outer cylinder 12.

  And the position in the outer cylinder 12 in which this mixing flow path 31 is formed becomes the mixing region L1, and when the intermediate partition gasket 16Y reaches the mixing region L1, the front mixing storage chamber 19a and the rear mixing chamber It is comprised so that between the storage chambers 19b may be connected. Here, the mixing channel 31 is longer than the thickness of the intermediate partition gasket 16Y and shorter than the sum of the thickness of the intermediate partition gasket 16Y and the thickness of the plunger gasket 15.

  The opening / closing means 20 provided in the front partition gasket 16X includes a through hole 21 formed in the front partition gasket 16X so as to be in the longitudinal direction of the outer cylinder 12, and a through hole 21 as shown in FIG. And a partitioning molded body 22 slidably disposed.

  The through-hole 21 of the front partition gasket 16X has an inner peripheral shape corresponding to the shape of the partition molded body 22, and an inner peripheral seal portion 21a is formed on the inner periphery thereof. The inner peripheral seal portion 21a is formed at a position corresponding to the outer peripheral seal portion 16a.

  The partition molding 22 is formed using a material that can be used for the outer cylinder 12, and has a constant cross-sectional shape in the longitudinal direction as shown in FIGS. 1 and 3. It has a columnar sealing portion 23 that is in liquid-tight and slidable contact with the portion 21a over the entire circumference. Here, the sealing portion 23 is disposed in a state of penetrating the inner peripheral seal portion 21 a of the through hole 21, and a flange portion 26 larger than the through hole 21 is formed on the inner housing chamber 19 side of the sealing portion 23.

  Projecting from the sealing portion 23 to the discharge portion 11 side so as to protrude from the end portion on the discharge portion 11 side of the front partition gasket 16X to the discharge portion 11 side in a state where the sealing portion 23 is disposed in the through hole 21. A portion 24 is provided. In this embodiment, the projecting portion 24 is formed continuously from the sealing portion 23, and includes a plurality of rib pieces 24 a formed to have an outer periphery smaller than the outer peripheral shape of the sealing portion 23.

  Then, a groove-like discharge flow path 25 formed between the rib pieces 24a, 24a is formed on the surface of the molded body 22 for partitioning on the discharge part 11 side from the sealing part 23, here, the surface of the protruding part 24. It is formed so as to be distributed substantially evenly around the molded body 22. The discharge channel 25 is closed between the inner mixing chamber 18b by the inner peripheral seal portion 21a on the one end 25a side in a state where the sealing portion 23 is disposed on the inner peripheral seal portion 21a of the through hole 21. The partition molding 22 is opened by moving relative to the front partition gasket 16X, and communicates between both end faces of the front partition gasket 16X. Further, a notch-like recess 24b is formed at the end of the rib piece 24a on the discharge portion 11 side at a position facing the discharge port 11c, and the protruding portion 24 contacts the end surface 11a of the discharge portion 11. In this state, a flow path from the discharge flow path 25 to the discharge port 11c can be secured.

  In such an opening / closing means 20, in a state where the sealing portion 23 is disposed on the inner peripheral seal portion 21a of the through hole 21, the discharge flow path 25 is blocked by the inner peripheral seal portion 21a on the front mixing chamber 19a side. Yes. When the partition molding 22 moves relative to the front partition gasket 16X toward the plunger 14 and the sealing portion 23 moves from the inner peripheral seal portion 21a of the through hole 21 toward the plunger 14, 25 is configured such that the front mixing storage chamber 19a side is open, and the both sides of the front partition gasket 16X are communicated with each other by the discharge flow path 25.

  On the other hand, the outer cylinder 12 of such a prefilled syringe 10 includes a cylindrical portion 12a having a constant cross-sectional shape in the longitudinal direction, and a mixing channel 31 is provided at a predetermined position in the middle of the cylindrical portion 12a in the longitudinal direction. At the same time, the front end side is closed by an end surface 11 a provided with the discharge portion 11. The mixing channel 31 is formed in a groove shape extending in the longitudinal direction by causing a part of the outer cylinder 12 to bulge outward. Here, the outer cylinder 12 having such a shape is integrally formed without combining a plurality of separate members.

As a material for molding the outer cylinder 12 and the partition molding 22 described above, a hard material that is stable with respect to the contents of the discharge chamber 18, the front mixing storage chamber 19a, and the rear mixing storage chamber 19b, for example, Various glass, synthetic resin, etc. are mentioned.
Synthetic resins that can be used as these materials include polyolefins such as low density or high density polyethylene, polypropylene, polybutadiene-1, polyvinyl chloride, polyvinylidene chloride, vinylidene chloride copolymers, polymethyl methacrylate, ethylene- Examples thereof include vinyl alcohol copolymers, acrylonitrile copolymers, polyethylene terephthalate, and polyethylene naphthalate.

  In the case of storing a substance to be administered to the human body, such as a medicine, in the front mixing storage chamber 19a and the rear mixing storage chamber 19b, polyolefins are preferable to prevent adverse effects such as eluate, and the water vapor barrier property is good. It is preferable to use a cyclic polyolefin that is difficult to adsorb components.

  Each of the plunger gasket 15 and the intermediate partition gasket 16Y has an outer peripheral shape corresponding to the inner wall surface of the outer cylinder 12, and has a plurality of rib-shaped outer peripheral seal portions 15s and 16s formed in an annular shape around the periphery. Is formed. These are made of an elastically deformable material, and the outer peripheral seal portions 15s and 16s are in fluid-tight and slidable contact with the inner wall surface of the outer cylinder 12 due to their elasticity.

  Examples of the material of the plunger gasket 15, the front partition gasket 16X, and the intermediate partition gasket 16Y include halogenated butyl rubber such as chlorine and bromine, butyl rubber such as divinylbenzene copolymer partially crosslinked butyl rubber, butyl rubber, Non-conjugated diene rubbers such as ethylene-propylene copolymer rubber (EPR), ethylene-propylene-diene monomer terpolymer rubber (EPDM), polyisoprene rubber, polybutadiene rubber, styrene butadiene copolymer rubber (SBR), acrylonitrile Various rubber materials such as butadiene copolymer rubber (NBR), natural rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, various elastomers such as polyurethane, polyester, polyamide, olefin, and styrene, Others can be used a material having a sealable resilient liquid-tight between these mixtures, the cylinder wall or the molded body.

  The materials of the plunger gasket 15, the front partition gasket 16X, and the intermediate partition gasket 16Y may all be the same, or may be different from each other depending on the contents. At that time, a butyl rubber rubber having a good water vapor barrier property is preferable, and in the case of containing a container that is easily adsorbed or adsorbed, a laminate or surface for reducing the adsorptivity of the container on the surface in contact with the container It is preferable to apply the treatment.

The prefilled syringe 10 having the above configuration is used as follows.
First, in the storage state, as shown in FIG. 4A, the plunger 14 is disposed on the rear end side of the outer cylinder 12, the gas is stored in the discharge chamber 18, the front mixing storage chamber 19a and the rear In the mixing chamber 19b, a predetermined amount of mixed components are separately stored.

  In this state, the front partition gasket 16X is disposed in the closed region, and the intermediate partition gasket 16Y is disposed closer to the plunger 14 than the mixing channel 31, and the mixing channel 31 and the rear mixing container are accommodated. The space between the chamber 19b is closed. Moreover, the discharge part 11 is also obstruct | occluded. Therefore, both the front mixing storage chamber 19a and the rear mixing storage chamber 19b are maintained in a sealed state.

  Here, the closed region of the front partition gasket 16X is a range in which the discharge flow path 25 from the position where the front partition gasket 16X is initially arranged to the vicinity of the discharge unit 11 can be maintained closed. This is a section for discharging the gas in the chamber 18. Specifically, the movement range of the front partition gasket 16 </ b> X until the projecting portion 24 protruding from the end portion on the discharge portion 11 side of the front partition gasket 16 </ b> X to the discharge portion 11 side contacts the end surface 11 a of the discharge portion 11. Thus, it is determined by the protruding amount of the protruding portion 24.

  In this closed region, the sealing portion 23 is disposed in contact with the inner peripheral seal portion 21a of the through hole 21 in a state of penetrating the inner peripheral seal portion 21a. Further, the protruding portion 24 protrudes toward the discharge portion 11 side from the discharge portion 11 side end portion of the front partition gasket 16X, and the end portion on the front mixing storage chamber 19a side of the discharge flow path 25 is formed by the inner peripheral seal portion 21a. It is blocked. Therefore, the space between the discharge chamber 18 and the front mixing storage chamber 19a is reliably maintained in a sealed state.

  In order to discharge the stored liquid stored in the front mixing storage chamber 19a and the rear mixing storage chamber 19b from the discharge port 11c during use, the tip cap 11d of the discharge portion 11 is removed, and the plunger 14 is connected to the discharge portion 11. By pushing the side, the mixed component in the rear mixing chamber 19b, the intermediate partition gasket 16Y, the mixed component in the front mixing chamber 19a, and the front partition gasket 16X, the gas in the discharge chamber 18 to the outside While discharging, it is moved to the discharge unit 11 side.

  Then, when the front partition gasket 16X is moved within the range of the closed region and the intermediate partition gasket 16Y reaches the mixing region L1, as shown in FIG. 4B, the mixing channel 31 is opened. Thus, the front mixing storage chamber 19a and the rear mixing storage chamber 19b communicate with each other.

  When the plunger 14 is further pressed toward the discharge portion 11 in this state, as shown in FIG. 4 (b), the mixed component in the rear mixing storage chamber 19b with the intermediate partition gasket 16Y positioned in the mixing region L1. Is transferred to the front mixing storage chamber 19a via the mixing channel 31. At this time, the front partition gasket 16X moves to the discharge portion 11 side while releasing the gas in the discharge chamber 18 to the outside. Then, as shown in FIG. 4C, the entire amount of the mixed components in the rear mixing storage chamber 19b is transferred and mixed by mixing with the mixed components in the front mixing storage chamber 19a in the front mixing storage chamber 19a. Is completed, and a dischargeable liquid such as a predetermined solution or dispersion is formed in the front mixing chamber 19a.

  Next, in a state where the discharge portion 11 is opened, and if necessary, a syringe 14 and a liquid feeding tube (not shown) are connected to the luer lock structure portion 11d or directly connected to the connector of the medical container, and the plunger 14 is further connected to the discharge portion 11. Press to the side. Then, the intermediate partition gasket 16Y is pressed by the plunger gasket 15 to move from the mixing region L1 to the discharge portion 11 side, and through the mixed components in the front mixing storage chamber 19a, for the front partition. The gasket 16X is pressed and moved, and as shown in FIG. 4 (d), the protruding portion 24 of the partition molding 22 of the opening / closing means 20 provided on the front partition gasket 16X is the discharge portion 11 of the outer cylinder 12. To the end surface 11a and reach the discharge area L2.

  Here, the discharge region L2 of the front partition gasket 16X is a range in the vicinity of the discharge unit 11, and is a section for discharging the mixed components in the front mixing storage chamber 19a. Specifically, this is a range after the protruding portion 24 of the partitioning molded body 22 comes into contact with the end surface 11 a of the discharge portion 11.

  Then, the protruding portion 24 of the partition molding 22 abuts against the end surface 11a of the discharge portion 11 to restrict the movement, and the front partition gasket 16X moves relative to the partition molding 22 toward the discharge portion 11 side. . As a result, as shown in FIG. 4E, the sealing portion 23 moves relatively to the front mixing storage chamber 19a side with respect to the front partitioning gasket 16X, so that the front mixing storage chamber 19a side of the discharge passage 25 is provided. Is opened to the front mixing storage chamber 19a side, the discharge flow path 25 is opened, and the front mixing storage chamber 19a communicates with the discharge section 11.

  Thereafter, when the plunger 14 is further pressed, the mixed component in the front mixing chamber 19a is pressurized by the intermediate partition gasket 16Y and discharged from the discharge portion 11 via the discharge flow path 25. Is done.

  And as shown in FIG.4 (f), discharge | emission of the mixed component from the prefilled syringe 10 is completed because the gasket 16X for front partition and the gasket 16Y for intermediate partitions move to the discharge part 11 side completely.

  According to the prefilled syringe 10 as described above, the intermediate partition gasket 16Y includes the mixing means 30 provided in the outer cylinder 12 with the mixing channel 31 opened when the intermediate partition gasket 16Y reaches the predetermined mixing region L1 of the outer cylinder 12. The front partition gasket 16X includes an opening / closing means 20 provided in the front partition gasket 16X, which is opened when the front partition gasket 16X reaches the predetermined discharge region L2, and the mixing channel 31 is opened. Since the mixing region L1 and the discharge region L2 are provided so that the discharge flow channel 25 is opened later, the mixing flow channel in a state where the front partition gasket 16X is disposed in the closed region and the discharge flow channel 25 is closed. By opening 31, the mixed component in the front mixing storage chamber 19 a and the mixed component in the rear mixing storage chamber 19 b are mixed in a state separated from the discharge chamber 18. Possible it is. Therefore, even when the mixing operation is performed in a state where the discharge part 11 is opened, the mixing operation is performed while reliably preventing a plurality of mixed components from coming into contact with the outside air or releasing a part of the mixed components to the outside. be able to.

  In addition, the front partition gasket 16X is provided with opening / closing means 20 having a through hole 21 and a partition molding 22 that is slidably disposed in the through hole 21, and the front partition gasket 16X is provided with the front partition gasket 16X. Since the discharge flow path 25 of the opening / closing means 20 can be opened by moving within the outer cylinder 12 and reaching the discharge area L2, in addition to the mixing flow path 31, another flow path is connected to the outer cylinder 12. There is no need to form. Therefore, the outer cylinder 12 can be made into a simple shape, and the outer cylinder 12 can be easily manufactured.

  In addition, the opening / closing means 20 is configured such that the front partition gasket 16X is relatively moved by the partition molding 22 being brought into contact with the end portion of the outer cylinder 12 on the discharge portion 11 side to restrict movement. When the front partition gasket 16X reaches the end of the outer cylinder 12 on the discharge portion 11 side, the discharge passage 25 can be opened, and the front partition gasket 16X and the partition molding 22 are relatively moved. Therefore, there is no need to provide a special shape portion inside the outer cylinder 12, and the shape of the outer cylinder 12 can be made simpler.

  Furthermore, since the mixing channel 31 is formed in a groove shape on the inner surface of the outer cylinder 12 between the front partition gasket 16X and the intermediate partition gasket 16Y, the partition molding 22 of the front partition gasket 16X. The operation of opening the discharge flow path 25 after the mixing flow path 31 is opened simply by setting the position of the mixing flow path 31 of the outer cylinder 12 according to the amount of protrusion from the end of the front partition gasket 16X Can be easily and reliably performed with a simple configuration.

  In addition, although the example which accommodated the medical chemical | medical solution was demonstrated in the said embodiment, even if it is a prefilled syringe used for uses other than medical use, it is possible to apply this invention.

  Further, in the above embodiment, as the mixing channel 31, the outer cylinder 12 is bulged outward to form a groove shape inside, but the mixing channel 31 is formed between both sides of each partitioning gasket. There is no particular limitation as long as it communicates. For example, as shown in FIG. 5, a mixing channel 31 a formed in a groove shape on the inner surface of the outer cylinder 12 without causing the outer cylinder 12 to bulge out may be used.

Furthermore, in the above embodiment, as the opening / closing means 20, the partition molding 22 has the flange portion 26 on the plunger 14 side and the protrusion 24 projects on the discharge portion 11 side. Although the discharge channel 25 is formed as a result of the movement toward the plunger 14 side, it is not particularly limited.
For example, as shown in FIG. 6 (a), as the opening / closing means 20, the partition molding 32 has a flange portion 36 and a sealing portion 33 on the discharge portion 11 side, and a discharge passage 35 inside. As shown in FIG. 6 (b), the partition molding 32 moves relative to the front partition gasket 16X toward the discharge portion 11 side, so that the discharge flow path 35 is located between both sides of the front partition gasket 16X. It is also possible to configure to communicate. In that case, after the front partition gasket 16X comes into contact with the discharge portion 11, the partition molding 32 may be relatively moved by the internal pressure of the mixed component in the front mixing storage chamber 19a.

  It is sectional drawing which shows the prefilled syringe of embodiment of this invention.   The gasket for front part partition of the prefilled syringe of Drawing 1 is shown, (a) is a perspective view and (b) is a sectional view.   The molded object for partitioning of the prefilled syringe of FIG. 1 is shown, (a) is a perspective view, (b) is sectional drawing.   (A)-(f) is a figure explaining the discharge | emission state of each component accommodated in the prefilled syringe of FIG.   It is sectional drawing which shows the modification of the communicating path of the prefilled syringe of FIG.   It is a partial cross section figure which shows the modification of the opening / closing means of the prefilled syringe of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Prefilled syringe 11 Discharge part 12 Outer cylinder 14 Plunger 15 Plunger gasket 16X Front partition gasket 16Y Intermediate partition gasket 18 Discharge chamber 19a Front mixing storage chamber 19b Rear mixing storage chamber 20 Opening and closing means 21 Through hole 22 Partitioning Molded body 24 Projection portion 25 Discharge flow path 30 Mixing means 31 Mixing flow path

Claims (5)

An outer cylinder having a discharge part, a plunger gasket disposed in a liquid-tight manner in the outer cylinder, and a plurality of partitions disposed in a liquid-tight manner between the discharge part and the plunger gasket in the outer cylinder. A plurality of partitioning gaskets, and a plurality of mixing storage chambers arranged adjacent to each other closer to the plunger side than the discharge chamber are partitioned by the plurality of partitioning gaskets, A plurality of mixed components discharged after mixing in the outer cylinder are prefilled syringes stored separately in the plurality of mixing chambers,
The plurality of partitioning gaskets include a front partitioning gasket for partitioning between the discharge chamber and the mixing storage chamber, and an intermediate partitioning gasket for partitioning between the plurality of mixing storage chambers,
A mixing means for opening a mixing channel communicating between the mixing chambers when the gasket for intermediate partition reaches the mixing region in the outer cylinder;
It has a through hole formed in the front partition gasket and a partition molding that is slidably disposed in the through hole, and the front partition gasket reaches a discharge area in the outer cylinder. Then, the partition gasket and the partition molding are relatively moved, and includes an opening / closing means for opening the discharge channel,
When the plurality of partitioning gaskets are moved by movement of the plunger gasket toward the discharge part, the mixing region and the discharge region are provided so that the discharge channel is opened after the mixing channel is opened. A prefilled syringe characterized by being made.   2. The prefilled syringe according to claim 1, wherein the opening / closing means moves the partitioning gasket relative to the partitioning molded body to open the discharge passage.   2. The prefilled syringe according to claim 1, wherein the opening and closing means moves the partition molding relative to the partition gasket and opens the discharge passage. 3.   The opening / closing means is configured such that one of the front partition gasket or the partition molding comes into contact with the discharge portion side end portion of the outer cylinder and the movement is restricted, so that the other is relatively moved. The prefilled syringe according to claim 2 or 3, wherein   5. The mixing channel of the mixing means is formed in a groove shape on the inner surface of the outer cylinder between the front partition gasket and the intermediate partition gasket. The prefilled syringe as described in any one.

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