JP2006090734A - Measurement result display system, and program - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide more easy grasping of a whole of measurement results in a measurement result display system. <P>SOLUTION: In a display control part 120, each sample 11 held in a multiplicity of sample holding parts 151 arranged two-dimensionally in a sample holding plate 150, and each measurement result obtained by measuring interaction with a predetermined physiologically active macromolecular substance by a surface plasmon measuring device 101 are displayed in a display part 110 in correspondence to a held position F(n, m) of each sample in the sample holding plate 150. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a measurement result display system, and more specifically, a measurement result display system for displaying a measurement result obtained by measurement using a sample storage plate having a large number of sample storage units arranged two-dimensionally, and the above measurement result The present invention relates to a program for causing a computer to execute a procedure for displaying.

  Conventionally, the interaction between each sample solution containing each of a number of different compounds and the protein that is the bioactive polymer substance of interest, such as the speed of a chemical binding reaction or a chemical dissociation reaction Screening is performed to search for compounds that are drug candidates that exhibit a predetermined interaction among the above-mentioned many compounds by measuring the speed of the above. The measurement results indicating the interaction are displayed in a table indicating the names of the compounds in the row direction on the display and the measurement items in the column direction, for example (see Patent Document 1).

In addition, there are various methods for measuring the interaction between the drug candidate compound and the protein. For example, many types of sample liquids containing different compounds are two-dimensionally formed in the sample storage plate. (For example, 96 or 384) each of which is accommodated in each sample container, and an apparatus for measuring the interaction between the compound contained in each sample solution and the protein of interest is known (patent) Reference 1 and non-patent reference 1).
JP 2001-330560 A PerkinElmer Japan Co., Ltd .: Multi-label / Luminescence counter: Catalog (2004 edition)

  By the way, as described above, the measurement result of the interaction between each sample solution stored in the two-dimensional sample storage plate and the protein of interest is shown, the name of each compound in the row direction, and the measurement item in the column direction. The method shown in the table shows that the measurement results corresponding to each sample solution can be grasped, but the whole measurement results are grasped, that is, for example, the whole compound that easily binds to the above protein. There is a problem that it is difficult to grasp. In particular, when there are several hundred types of the above compounds, the measurement results do not fit in one screen of the display, and when the measurement results are scrolled to view the measurement results, it becomes more difficult to grasp the entire measurement results. .

  The present invention has been made in view of the above circumstances, and an object thereof is to provide a measurement result display system capable of more easily grasping the entire measurement result and a program for causing a computer to execute the above procedure. To do.

  The first measurement result display system according to the present invention includes a display unit, and each sample stored in each sample storage portion of a sample storage plate in which a large number of sample storage portions are two-dimensionally arranged. A measurement result display system comprising display control means for displaying a measurement result obtained by measuring an interaction between a predetermined physiologically active polymer substance with a measuring device on the display means, The control means displays each measurement result corresponding to each sample on the display means in correspondence with the accommodation position of each sample in the sample accommodation plate.

  The second measurement result display system of the present invention includes a plurality of samples in which the display means and a large number of sample accommodating portions for accommodating the samples are arranged two-dimensionally and the arrangement pattern of the large number of sample accommodating portions is the same. For each sample accommodated in each sample accommodating portion of the plate, each measurement result obtained by measuring the interaction between each sample and a predetermined physiologically active polymer substance with a plurality of measuring devices is displayed. Measurement result display system comprising a display control means for displaying on each sample plate, so that each sample plate is arranged in a sample storage portion at a different position in the arrangement pattern of the sample storage portion, Each sample is distributed and stored in each sample plate, and the display control means displays each of the measurement results corresponding to each sample obtained by each measurement device in the arrangement pattern of the sample storage unit. Is characterized in that to simultaneously displayed on different display means in correspondence with the housing position of each sample are.

  The first measurement result display program according to the present invention includes a sample and a predetermined physiology for each sample accommodated in each sample accommodating portion of a sample accommodating plate in which a large number of sample accommodating portions are two-dimensionally arranged. A measurement result display program for displaying on a display means a measurement result obtained by measuring an interaction with an active polymer substance with a measuring device, each of the measurement result corresponding to each sample, The computer is caused to execute a procedure for displaying on the display means in correspondence with the storage position of each sample in the sample storage plate.

According to the second measurement result display program of the present invention, each sample of a plurality of sample plates in which a large number of sample accommodating portions for accommodating samples are two-dimensionally arranged and the arrangement pattern of the many sample accommodating portions is the same. For displaying each measurement result obtained by measuring the interaction between each sample and a predetermined physiologically active polymer substance with a plurality of measuring devices for each of the samples stored in the storage unit. The measurement result display program of
Each sample plate is distributed and accommodated in each sample plate so that each sample is arranged in a sample accommodating portion at a different position in the arrangement pattern of the sample accommodating portion,
The computer executes a procedure for displaying the measurement results corresponding to the respective samples obtained by the respective measuring apparatuses on the display means in a batch manner in correspondence with the different sample storage positions in the arrangement pattern of the sample storage unit. It is something to be made.

  “Two-dimensionally arranged” means that two or more are arranged in the vertical direction and the horizontal direction.

  The physiologically active polymer substance is a substance described as “Natural Polymer” (symbols 11001 to 11025) in Japanese Industrial Standards (JIS) K3611, “Biological Data Encyclopedia (Asakura Shoten)” 1. Sugars, amino acids, nucleotides, lipids, heme, quinones, proteins, RNA, DNA, phospholipids, polysaccharides, and “II. Biological substances and metabolism” in the Bioscience Dictionary (Asakura Shoten) Which includes any one or more of proteins, amino acids, nucleic acids, lipids, carbohydrates and enzymes described in the above.

  The interaction is the speed of the binding reaction, the binding amount, or the speed of the dissociation reaction in a physical, chemical, or biochemical reaction, or the speed of the binding reaction, the binding amount, and the dissociation. It means a combination of two or more of the reaction speeds.

  The sample contains a compound, and it is desirable that the compound is dissolved in a solvent.

  The compound of the present invention refers to a molecule composed of two or more elements. In the present invention, a compound having a molecular weight of 50 or more and 1,000,000 or less is mainly targeted, but the present invention can also be applied to a compound having a molecular weight of less or more.

  The measurement apparatus may perform measurement using total reflection attenuation. The measurement using total reflection attenuation means that when the light beam is totally reflected on the metal surface and surface plasmon is generated, the light beam undergoes rapid attenuation (total reflection attenuation) in the totally reflected light beam. It means a measurement performed by utilizing the fact that the specific reflection angle to be generated, that is, the total reflection attenuation angle changes according to the dielectric constant in the vicinity of the metal surface. Further, a leakage mode measurement device is known as an example of a device that performs measurement using the total reflection attenuation. This leakage mode measuring device includes a dielectric block formed in a prism shape, a clad layer formed on one surface of the dielectric block, and an optical waveguide formed on the clad layer and brought into contact with a sample solution. An optical system that causes the light beam to enter the dielectric block at various angles so that a total reflection condition is obtained at the interface between the dielectric block and the cladding layer. And a light detection means for detecting the excitation state of the waveguide mode, that is, the total reflection attenuation state by measuring the intensity of the light beam totally reflected at the interface. Vol. 1 (1998) ”, pages 21 to 23 and pages 26 to 27.

  The measurement result may indicate whether the bulk correction has been performed normally.

  Bulk correction means that a chemical bond is formed between two components including a value indicating a change in the total reflection attenuation angle measured for the sample, that is, the bioactive polymer substance in the sample. The component changed due to the influence of the element without any difference from the component changed due to the influence of the element that causes chemical binding between the physiologically active polymer substance in the sample, and the measured value is This means that the correction is performed so that only the component changed by the influence of the element causing the coupling is shown.

  The measurement results include a predetermined range of values determined in advance for at least one of the association rate constant (Ka), the dissociation rate constant (Kd), the dissociation constant (KD), and the maximum binding amount (Rmax). It may indicate whether it has been sought.

  The binding rate constant Ka is a value indicating the speed of the binding reaction.

  The dissociation rate constant Kd is a value indicating the speed of the dissociation reaction.

  The dissociation constant KD is a value obtained by dividing the dissociation rate constant Kd by the binding rate constant Ka. That is, the dissociation constant KD is a value represented by the equation: dissociation constant KD = dissociation rate constant Kd / binding rate constant Ka.

  The maximum binding amount Rmax indicates the amount of chemical binding between the sample and the bioactive polymer substance when the chemical binding reaction is saturated between the sample and the bioactive polymer substance. It is.

  The inventor of the present application has arrived at the present invention by paying attention to the fact that the examiner who examines the above measurement results generally grasps the accommodation position of each sample in the sample plate.

  According to the first measurement result display system and program of the present invention, the display control means causes the display means to display each of the measurement results corresponding to each sample corresponding to the accommodation position of each sample in the sample accommodation plate. Since it did in this way, the measurement result corresponding to the specific sample displayed on the display means can be grasped in association with the accommodation position of the sample in the sample plate, and the accommodation position of each sample in the sample accommodation plate is known in advance. As a result, the entire measurement results corresponding to the large number of samples can be easily grasped. In particular, when the number of compounds to be displayed is as large as several hundred, a remarkable effect of more easily grasping the entire measurement result can be obtained.

  According to the second measurement result display system and program of the present invention, for each sample accommodated in each sample accommodating portion of a plurality of sample plates having the same arrangement pattern of a large number of sample accommodating portions, When displaying each measurement result obtained by measuring the interaction with a predetermined physiologically active polymer substance with a plurality of measuring devices on the display means, the sample accommodation at different positions in the arrangement pattern of the sample accommodation portion is performed. Each sample is distributed and accommodated in each sample plate so that each sample is arranged in the unit, and each of the measurement results corresponding to each sample obtained by each measurement apparatus is represented in the arrangement pattern of the sample accommodation unit. Since it is made to display on the said display means collectively corresponding to the accommodation position of each different sample, the same effect as the said 1st measurement result display system can be acquired, Et al, it is possible to enjoy even the effect of shortening the measuring time by measuring dispersed can accommodate samples one sample plate by a plurality of measuring devices.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. The measurement result display system 100 according to the first embodiment of the present invention shown in FIG. 1 uses a display 110 as a display unit and a sample storage plate 150 having a large number of sample storage units 151 arranged two-dimensionally. The measurement apparatus 101 measures the interaction between each of the different samples 11a, 11b... (Hereinafter collectively referred to as the sample 11) accommodated in each sample accommodating portion 151 and a predetermined physiologically active polymer substance. And a display control unit 120 for displaying the measurement result obtained on the display 110.

  The display control unit 120 displays each measurement result corresponding to each sample 11 on the display 110 in correspondence with the accommodation position of each sample 11 in the sample accommodation plate 150.

  The sample storage plate 150 has a total of 384 (384 = 16 × 24) sample storage units 151 in the row direction (horizontal direction) and 24 in the column direction (vertical direction). In addition, when each location of each sample accommodating part 151 is pointed out individually, it shows as a matrix-like sample accommodating position F (m, n) of 16 rows × 24 columns. Note that m represents the row direction (m = 1 to 16), and n represents the column direction (n = 1 to 24).

  As the measuring apparatus 101, a conventionally known surface plasmon measuring apparatus or the like can be adopted. Hereinafter, the measuring apparatus 101 is referred to as a surface plasmon measuring apparatus 101.

  Next, the operation of the first embodiment will be described.

  The sample dispensing robot 160 shown in FIG. 1 dispenses each sample 11 made of a sample solution containing different compounds to the first 20 rows (n = 1 to 20) of the sample storage unit 151. Further, the control liquid 33 serving as a reference for each sample is dispensed into the last four rows (n = 21 to 24) of the sample storage unit 151. Each sample 11 and the control liquid 33 are prepared in advance in a mother plate (not shown), and each sample 11 and the control liquid 33 sucked from the mother plate by the sample dispensing robot 160 is provided for each sample 11 and the control liquid 33. Dispense into the sample container 151.

  It is known in advance that the control solution 33 does not bind to a solution that is known in advance to bind to a physiologically active polymer substance that is fixed to each measurement chip 9 described later, or the physiologically active polymer substance. One of the solutions is used.

  Thereafter, the sample containing plate 150 containing the sample 11 and the control liquid 33 is attached to the surface plasmon measuring apparatus 101. At the same time, information indicating each sample 11 and the control liquid 33 associated with the sample storage position F (m, n) is input from the sample dispensing robot 160 to the display control unit 120. The input of this information may be executed via the recording medium 31 or may be executed via a network.

  On the other hand, the protein immobilizer 162 receives a chip plate 166 containing 64 chip assemblies 164 in which six measuring chips 9 described later are connected, and measures a total of 384 pieces (6 × 64) on the chip plate 166. A protein, which is an example of a physiologically active polymer substance, is fixed to the chip 9. Thereafter, the chip plate 166 is attached to the surface plasmon measuring apparatus 101. Here, the chip coupling body 164 may handle 16 (16 × 16) measuring chips 9 as one set, ie, 16 sets arranged in the row direction.

  For the immobilization of the protein on the measurement chip, for example, real-time analysis experiment method of biological material interaction, Kazuhiro Nagata, Koji Hiroshi, published by Springer Fairlake Tokyo Co., Ltd. can be referred to. Moreover, about the said surface plasmon measuring apparatus and a measurement chip, Unexamined-Japanese-Patent No. 2001-330560 etc. can be referred, for example.

  The surface plasmon measurement apparatus 101 that has received the sample storage plate 150 and the chip plate 166 has five of the six measurement chips 9 that constitute the chip coupling body 164 taken out from the chip plate 166, as shown in FIG. For each measurement chip 9, five different samples 11 among the samples 11 accommodated in 1 to 20 rows (m = 1 to 20) of the sample accommodation positions F (m, n) of the sample accommodation plate 150 are divided. Note that the total reflection attenuation angle is measured, and the remaining one of the six measurement chips 9 is selected from among the control liquids 33 accommodated in the 21 to 24 rows of the sample accommodation positions F (m, n). Dispense one and measure the total reflection attenuation angle.

  As shown in FIG. 2, the measurement by the surface plasmon measurement apparatus 101 is performed by injecting the sample 11 or the control liquid 33 sucked by the pipette 171 from the sample storage portion 151 of the sample storage plate 150 into the measurement chip 9. Is irradiated with a light beam Le, and the subsequent change in the total reflection attenuation angle is read over time, and the binding and dissociation between the protein immobilized on each measurement chip 9 and the compound contained in the sample 11 are detected. Measurement data indicating the state is obtained. That is, in the surface plasmon measurement apparatus 101, each measurement chip 9 of the chip coupling body 164 is sequentially moved to the measurement position P1 of the total reflection attenuation angle, and each measurement chip moved to that position every time the movement is performed. The sample 11 or the control liquid 33 is injected from the pipette 171 to 9 and the total reflection attenuation angle that changes with the passage of time is measured.

  The measurement of the control liquid 33 is performed in order to obtain a more accurate measurement result. For example, for bulk correction using the measurement result of the control liquid, refer to JP-A-2003-279478. be able to.

  By performing the same measurement as the above on the remaining 23 chip linking bodies 164 held on the chip plate 166, all the 384 measurement chips and all the sample storage positions F (m, n) of 384 are obtained. The total reflection attenuation angle can be measured by a combination with each sample 11 accommodated in ().

  Further, the surface plasmon measuring apparatus 101 calculates values of the binding rate constant Ka, the dissociation rate constant Kd, the dissociation constant KD, and the maximum binding amount Rmax based on the measurement of the total reflection attenuation angle that changes with the passage of time. In addition, the following measurement results are obtained by performing bulk correction and the like.

  That is, for each of the values of the binding rate constant Ka, the dissociation rate constant Kd, the dissociation constant KD, and the maximum binding amount Rmax, a measurement result indicating whether or not a value in a predetermined range determined in advance is obtained, and bulk correction is performed. A measurement result indicating whether or not the operation has been performed normally is obtained. These results are input to the display control unit 120 corresponding to each sample 11.

  Next, display of the measurement result on the display 110 by the display control unit 120 will be described.

  3A and 3B show the measurement results displayed on the screen of the display 110. FIG.

  A total of 384 thumbnails G (m, n) arranged in a matrix of 16 rows × 24 columns shown in FIG. 3A are sample storage positions F (m, n) on the sample storage plate 150. It is displayed corresponding to.

  That is, the display control unit 120 acquires from the surface plasmon measurement apparatus 101 information indicating each sample 11 and each control liquid 33 associated with the sample storage position F (m, n) acquired from the sample dispensing robot 160. Based on the measurement results corresponding to each sample 11 and each control liquid 33, the measurement results corresponding to the sample 11 accommodated in the sample accommodation position F (m, n) m, n) are displayed on the display 110. Each of the measurement results displayed on the display 110 in correspondence with each sample storage position F (m, n) is each thumbnail G (m, n).

  Thus, if each sample 11 stored in each sample storage position F (m, n) is known in advance, the thumbnail G (m, n) displayed on the screen indicates the measurement result for which sample. Can be easily grasped.

  The display result will be described more specifically.

  When the value of the predetermined range for the maximum coupling amount Rmax is obtained, the thumbnail G is displayed with the thick frame Q1 surrounded, and when the value of the predetermined range is not obtained, the display is not changed. In addition, a value for which a predetermined range value for the dissociation rate constant Kd is obtained is indicated by a thumbnail G having a colored background color Q2, and a value for which the value for the predetermined range is not obtained is not changed. To do. In addition, with regard to the binding rate constant Ka, dissociation constant KD, and bulk correction, the measurement results can be obtained by changing the display using the same method, for example, different colors, blinking, hatching, frame thickness, etc. It can be easily grasped.

  In the thumbnail G (m, n), data obtained by measurement of each control solution 33 is displayed in the range of m = 1 to 16 and n = 21 to 24.

  Further, as shown in FIG. 3B, when one of the thumbnails G (m, n), for example, the thumbnail G (3, 3) is clicked, an enlarged image G of the thumbnail G (3, 3) is clicked. Is displayed, and the following items are displayed in this enlarged image.

(1) Information on sample components used for measurement (indicated by K1 in the figure)
(2) Kintics value (indicated by K2 in the figure)
The four values of the binding rate constant Ka, the dissociation rate constant Kd, the dissociation constant KD, and the maximum binding amount Rmax of the sample substance are collectively referred to as a Kintics value.

(3) Measurement signal display (indicated by K3 in the figure)
This measurement signal indicates the change in the total reflection attenuation angle with the passage of time on the coordinates with time on the horizontal axis and angle on the vertical axis. The figure shows a bond dissociation curve α based on an actual measurement signal and a bond dissociation curve β based on an estimated Kintics value. The bond dissociation curve α based on the actual measurement signal is indicated by a solid line (black), and the bond dissociation curve β based on the estimated Kintics value is indicated by a broken line (blue). The maximum value of the horizontal axis of the coordinates is automatically determined according to the time required for the measurement, and the scale indicating the angle of the vertical axis can be set by the user.

  FIG. 4 is a block diagram showing a schematic configuration of a measurement result display system 200 according to the second embodiment of this invention. Hereinafter, the same reference numerals are used for components having the same functions as those of the measurement result display system 100 of the first embodiment, and description thereof is omitted.

  In the measurement result display system 200 according to the second embodiment, the display 110 and a large number of sample storage portions 151 for storing different samples 11 are arranged two-dimensionally. Using a plurality of sample plates 150A, 150B, 150C, and 150D (hereinafter collectively referred to as sample plates 150) having the same arrangement (arrangement pattern) of each sample plate 150A, 150B,... 151, a plurality of surface plasmon measuring devices 101A, 101B, 101C, and 101D (hereinafter collectively referred to as surface plasmon measuring device 101). A display control unit 220 for displaying each measurement result obtained by the measurement on the display 110. Eteiru.

  Each sample plate 150A, 150B,... Is arranged so that each sample 11 is placed in each sample storage part 151 at a different position in the same arrangement pattern of the sample storage part 151. , 150B,... Further, each of the sample plates 150A, 150B,... Is the same as the sample plate 150 in the first embodiment, and a total of 384 (384 = 16 × 24) sample storage positions F (m) of 16 rows × 24 columns. , N) have each sample storage portion 151.

  That is, in this measurement result display system 200, each sample 11 accommodated in each sample accommodating portion 151 of one sample plate 150 in the first embodiment is converted into a plurality of sample plates 150A, 150B,. The distribution positions of the different samples 11 distributed in the sample plates 150A, 150B,... Are the sample storage positions F of the samples 11 in the first embodiment. Each sample 11 is accommodated in each sample accommodating portion 151 of each sample plate 150A, 150B,... Corresponding to (m, n).

  The display control unit 220 stores each of the measurement results corresponding to each sample 11 obtained by each surface plasmon measurement device 101A, 101B,... In each of the different sample 11 in the arrangement pattern of the sample storage unit 151. The display 110 collectively displays the positions corresponding to the sample storage positions F (m, n).

  Hereinafter, the operation of the measurement result display system 200 will be described.

  From the mother plate (not shown) prepared in advance by the sample dispensing robot 160 to the first 20 rows (n = 1 to 20) of the sample storage portions 151 in the sample plates 150A, 150B,. A sample 11 made of a sample solution containing different compounds is dispensed. Further, the reference control liquid 33 is dispensed into the last four rows (n = 21 to 24) of the sample storage unit 151.

  Here, as shown in FIG. 5, for example, with respect to four sample storage positions F (1,1), F (2,1), F (1,2), and F (2,2) adjacent to each other, The plate 150A accommodates the sample 11 only in the sample accommodating position F (1, 1), the sample plate 150B accommodates the sample 11 only in the sample accommodating position F (1, 2), and the sample plate 150C is in the sample accommodating position F ( 2 and 1), the sample 11 is accommodated only, and the sample plate 150D accommodates the sample 11 only in the sample accommodation position F (2, 2). In the same manner, the sample plates 150A, 150B,... Are not duplicated at the same sample accommodation position and do not accommodate the sample 11.

  Note that the division of each sample 11 into the respective sample plates 150A, 150B,... Is not limited to the above, and any division method may be adopted. For example, with respect to the sample plate 150A, the sample 11 is dispensed into the sample storage portion 151 included in the range of m = 1 to 8 and n = 1 to 12 in the sample storage position (m, n), and the sample plate 150B is Is the range of m = 1 to 8 and n = 13 to 24 in the sample storage position (m, n), and for the sample plate 150C, m = 9 to 16 in the sample storage position (m, n) and n = In the range of 1 to 12, for the sample plate 150D, the sample 11 is dispensed to the sample storage unit 151 included in the range of m = 9 to 16 and n = 13 to 24 in the sample storage position (m, n). It may be.

  Thereafter, each of the sample storage plates 150A, 150B,... Containing the sample 11 and the control liquid 33 is mounted on each surface plasmon measurement device 101A, 101B,. Then, the sample dispensing robot 160 inputs information indicating each sample 11 and the control liquid 33 associated with the sample accommodation position F (m, n) to the display control unit 120. The input of this information may be executed via the recording medium 31 or may be executed via a network.

  On the other hand, the protein immobilizing machine 162 receives a chip plate 166 containing 64 chip coupling bodies 164 in which six measuring chips 9 are coupled, and immobilizes proteins on a total of 384 measuring chips 9 on the chip plate 166. . Thereafter, 16 chip-connected bodies 164 arranged in the row direction are handled as one set, and each chip-connected body 164 including 96 (6 × 16) measuring chips 9 in each set is connected to each surface plasmon. Supplied to the measuring devices 101A, 101B.

  Each of the surface plasmon measuring devices 101A, 101B,... That has received the sample storage plates 150A, 150B,... And each set of the chip coupling body 164 is a chip as in the first embodiment. For each of the five measurement chips 9 in the six measurement chips 9 of the coupling body 164, the samples 11 stored in the 1 to 20 rows (m = 1 to 20) of the sample storage positions F (m, n) are mutually connected. Each of the five different samples 11 is dispensed to measure the total reflection attenuation angle, and the remaining one of the six measurement chips 9 is arranged in 21 to 24 rows of sample accommodation positions F (m, n). One of the accommodated control liquids 33 is dispensed and the total reflection attenuation angle is measured.

  Each of the surface plasmon measurement devices 101A, 101B,... Obtains each value of the binding rate constant Ka, the dissociation rate constant Kd, the dissociation constant KD, and the maximum binding amount Rmax, as in the first embodiment. Then, the following measurement results are obtained by performing bulk correction and the like.

  That is, for each of the values of the binding rate constant Ka, the dissociation rate constant Kd, the dissociation constant KD, and the maximum binding amount Rmax, a measurement result indicating whether or not a value in a predetermined range determined in advance is obtained, and bulk correction is performed. A measurement result indicating whether or not the operation has been performed normally is obtained. These results are input to the display control unit 120 corresponding to each sample 11.

  The display control unit 120 includes information indicating each sample 11 and each control liquid 33 associated with the sample storage position F (m, n) acquired from the sample dispensing robot 160, and each surface plasmon measurement device 101A, 101B. Based on the measurement results corresponding to the samples 11 and the control liquids 33 acquired from the samples, the measurement results corresponding to the samples 11 stored in the sample storage position F (m, n) Each thumbnail G (m, n) is displayed on the display 110 in correspondence with the accommodation position F (m, n). This display mode is the same as the display mode in the first embodiment.

  Thus, by measuring the total reflection attenuation angle for each sample 11 using a plurality of measuring devices, a predetermined measurement result can be obtained in a shorter time.

  The method of dispersing and storing the samples 11 in the sample plates 150A, 150B,... So that the samples 11 are arranged at different positions in the arrangement pattern of the sample storage portion 151 is the case of the above method. Not limited to any method. For example, regarding the sample storage positions F (m, n) of a total of 384 (384 = 16 × 24) in 16 rows × 24 columns, for the sample plate 150A, the storage sample storage positions F (m, n; m = 1 to 4, n = 1-24), for the sample plate 150B, the stored sample storage position F (m, n; m = 5-8, n = 1-24), for the sample plate 150C, the stored sample storage position F (m, n; m = 9 to 12, n = 1 to 24), and for the sample plate 150D, each sample 11 is dispersed in the accommodation sample accommodation position F (m, n; m = 13 to 16, n = 1 to 24). May be accommodated.

  In addition to a display such as a CRT or a liquid crystal display, a display unit for displaying the measurement result may employ any display device such as a printer or a plotter as long as the display result can be visually confirmed. .

  In addition, the measurement result display system of the present invention includes data from a device for measuring the interaction obtained by measurement using total reflection attenuation, luminescence measurement, fluorescence measurement, absorbance measurement, UV absorbance measurement, time-resolved fluorescence. It is also possible to simultaneously display data from an apparatus for measuring the interaction obtained by measurement or fluorescence polarization measurement.

  Note that a program for causing a computer to execute the measurement result display method of the above embodiment corresponds to the measurement result display program of the present invention.

The block diagram which shows schematic structure of the measurement result display system of the 1st Embodiment of this invention The figure which shows a mode that a sample liquid is inject | poured into the measurement chip | tip of a chip | tip coupling body, and a total reflection attenuation is measured. The figure which shows the measurement result which is displayed on the screen of the display The block diagram which shows schematic structure of the measurement result display system of the 2nd Embodiment of this invention Shows how samples are distributed in each sample storage section of each sample storage plate

Explanation of symbols

DESCRIPTION OF SYMBOLS 9 Measuring chip 11 Sample 100 Measurement result display system 101 Surface plasmon measuring device 110 Display 120 Display control part 151 Sample accommodating part 150 Sample accommodating plate 160 Sample dispensing robot 162 Protein immobilizer 164 Chip coupling body

Claims (10)

For each of the samples accommodated in each sample accommodating portion of the display means and the sample accommodating plate in which a large number of sample accommodating portions are arranged two-dimensionally, between each sample and a predetermined physiologically active polymer substance A measurement result display system comprising display control means for causing the display means to display a measurement result obtained by measuring an interaction with a measuring device;
The display control means displays each measurement result corresponding to each sample on the display means in correspondence with the storage position of each sample in the sample storage plate. system. Each sample accommodated in each sample accommodating part of a plurality of sample plates in which the display means and a large number of sample accommodating parts accommodating samples are arranged two-dimensionally and the arrangement pattern of the many sample accommodating parts is the same A display control means for causing the display means to display each measurement result obtained by measuring the interaction between each sample and a predetermined physiologically active polymer substance with a plurality of measurement devices. A measurement result display system,
Each sample plate is distributed and accommodated in each sample plate so that each sample is arranged in a sample accommodating portion at a different position in the arrangement pattern of the sample accommodating portion,
The display control means collectively displays on the display means the measurement results corresponding to the samples obtained by the measuring devices in correspondence with the different sample storage positions in the sample storage portion arrangement pattern. A measurement result display system characterized in that   The measurement result display system according to claim 1, wherein the measurement device performs measurement using total reflection attenuation.   4. The measurement result display system according to claim 3, wherein the measurement result indicates whether or not the bulk correction is normally performed.   The measurement result is a predetermined range of values determined in advance for at least one of a binding rate constant (Ka), a dissociation rate constant (Kd), a dissociation constant (KD), and a maximum binding amount (Rmax). 4. The measurement result display system according to claim 3, wherein the measurement result display system indicates whether it has been obtained. Measures the interaction between each sample and a predetermined physiologically active polymer substance for each sample housed in each sample housing part of a sample housing plate in which a large number of sample housing parts are arranged two-dimensionally A measurement result display program for displaying on a display means a measurement result obtained by measuring with an apparatus,
A measurement result display program for causing a computer to execute a procedure of displaying each of the measurement results corresponding to each sample on the display means in correspondence with the accommodation position of each sample in the sample accommodation plate. For each sample accommodated in each sample accommodating portion of a plurality of sample plates in which a large number of sample accommodating portions for accommodating samples are arranged two-dimensionally and the arrangement pattern of the multiple sample accommodating portions is the same, A measurement result display program for displaying on a display means each measurement result obtained by measuring the interaction between each sample and a predetermined physiologically active polymer substance with a plurality of measuring devices,
Each sample plate is distributed and accommodated in each sample plate so that each sample is arranged in a sample accommodating portion at a different position in the arrangement pattern of the sample accommodating portion,
The computer executes a procedure for displaying the measurement results corresponding to the respective samples obtained by the respective measuring apparatuses on the display means in a batch manner in correspondence with the different sample storage positions in the arrangement pattern of the sample storage unit. Measurement result display program   The measurement result display program according to claim 6 or 7, wherein the measuring device performs measurement using total reflection attenuation.   9. The measurement result display program according to claim 8, wherein the measurement result indicates whether or not the bulk correction is normally performed.   The measurement result is a predetermined range of values determined in advance for at least one of a binding rate constant (Ka), a dissociation rate constant (Kd), a dissociation constant (KD), and a maximum binding amount (Rmax). 9. The measurement result display program according to claim 8, which indicates whether or not it has been obtained.

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