JP2003213548A - Auxiliary therapeutic tool - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an auxiliary therapeutic tool capable of relieving discomfort of an patient, by calming itchiness caused by inflammation, such as atopic dermatitis, and therefore capable of enhancing a therapeutic effect on the inflammation. <P>SOLUTION: This auxiliary therapeutic tool is given by knitting yarn to have a double-layer structure of inner and outer surfaces, wherein the inner surface is contacted with the skin and contains the yarn on which a metal phthalocyanine derivative is supported, and the outer surface is formed out of the other yarn on which no metal phthalocyanine derivative is supported. An iron phthalocyanine polycarboxylic acid, an iron phthalocyanine polysulfonic acid, a cobalt phthalocyanine polycarboxylic acid, a cobalt phthalocyanine polycarboxylic acid, and a water-soluble salt thereof are preferably exemplified as the metal phthalocyanine derivative. When the metal phthalocyanine derivative is made to be supported on the yarn, one or more kinds of raw materials selected from cotton, rayon, flax, wool, silk, and polyamide are treated with a cationization agent, and then the metal phthalocyanine derivative is made to act on the treated yarn, so that the derivative is supported on the yarn. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a therapeutic aid for soothing itching associated with inflammation of the skin such as atopic dermatitis and assisting the treatment of inflammation.

[0002]

2. Description of the Related Art Recently, atopic dermatitis has begun to occur, dry skin,
The number of patients with inflammation accompanied by itching, such as those wearing casts, is increasing, and it is said that the number of patients with atopic dermatitis alone reaches 9 million. In particular, atopic dermatitis requires a long period of time to be completely cured, and during that time, it is necessary to endure discomfort, which is a great pain for patients. Patients with inflammation accompanied by itching sometimes scratch the patient's eyes without being able to tolerate itching or while sleeping, and the scratches also cause a delay in healing. Therefore, removing or soothing the itch not only alleviates the discomfort of the patient, but also greatly assists the therapeutic effect.

Generally, the main mechanism of itching in diseases is that substances such as histamine and allergens that cause itching and physical irritation act on itching receptors present on the skin and some mucous membranes, and these act on the brain through nerve cells. It is believed to be due to being transmitted. In other words, when itching is felt on a part of the body, the itching also causes itching on other parts, and the sensation of itching becomes more intense at an accelerating rate, which further increases the discomfort. .

Antihistamines, steroids, moisturizers, etc. are mainly used as a method for suppressing itch, but antihistamines and steroids may cause side effects, so it is necessary to refrain from excessive use, and moisturizers should be used. The agent had a limited effect. In addition to this, a non-woven fabric bandage for undercast casting containing a zeolite carrying a compound such as silver, copper or zinc [JP-A-5-154174], at the end obtained by reacting a polyether polyol and a polyisocyanate A moisture-curing fixing bandage containing a resin composition containing an antibacterial porous inorganic capsule containing a protein powder and an antibacterial zeolite encapsulated by a water-insoluble porous inorganic compound in a prepolymer containing an isocyanate group (Patent Document 1 6-
There is also a proposal that a compound having an antipruritic effect is carried on the fiber and adhered to the itchy spot, but there is a limit to the effect, and when it is continued for a long time, it is secondary to the skin. There is also a problem that it may cause inflammation, and further, when these fibers are washed, the medicinal component flows and cannot be used repeatedly.

[0005]

SUMMARY OF THE INVENTION In view of the above problems, an object of the present invention is a treatment for soothing the itch associated with inflammation such as atopic dermatitis, soothing the discomfort of the patient and enhancing the therapeutic effect of inflammation. To provide auxiliary equipment.

[0006]

In order to solve the above-mentioned problems, the invention according to claim 1 is a therapeutic aid for calming itch by adhering it to the irritated skin with itching, and the inner surface in contact with the skin is Formula (I) [In the formula, R is a carboxyl group, a sulfonic acid group, or a group selected from these water-soluble bases, n is 1 or 2 in the number of R, M is iron (Fe), cobalt ( Co), manganese (Mn), titanium (Ti),
Vanadium (V), nickel (Ni), copper (Cu), zinc (Zn), molybdenum (Mo), tungsten (W)
It is characterized in that it includes a thread carrying a metal phthalocyanine derivative represented by the formula [1], and the outer surface is knitted into a double structure consisting of threads not carrying the metal phthalocyanine derivative.

[Chemical 2]

The invention according to claim 2 is the therapeutic aid according to claim 1, wherein the metal phthalocyanine derivative is iron phthalocyanine polycarboxylic acid, iron phthalocyanine polysulfonic acid, cobalt phthalocyanine polycarboxylic acid, cobalt phthalocyanine polysulfonic acid, and It is characterized in that it is at least one selected from these water-soluble salts.

The invention according to claim 3 is the therapeutic aid according to claim 1, wherein the thread carrying the metal phthalocyanine derivative is one or more materials selected from cotton, rayon, hemp, wool, silk and polyamide. It is characterized in that it is treated with a cationizing agent, and then a metal phthalocyanine derivative is allowed to act thereon for supporting.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The therapeutic aid of the present invention is attached so as to directly contact the skin of an itchy part or an inflamed part, soothes the itching and enhances the therapeutic effect on inflammation. . The shape of the treatment aid may be in the form of normal undergarments such as shirts, pants or stockings, or it may be worn on the hands, elbows, shoulders, hips, knees, legs and feet to reduce joint and muscle pain. It may be partially covered, such as a softening tubular or wound supporter. However, the treatment aid of the present invention does not need to be tightly attached to the body unlike a supporter for the purpose of relieving pain in joints and muscles,
It suffices that it is always in contact with the target skin portion and that it can be moved freely. From this viewpoint, it is convenient to knit a yarn to form a knit fabric that is highly stretchable in the longitudinal and transverse directions.

The knitted fabric in the treatment aid is knitted in a double structure in which the yarn mainly used for the surface contacting the skin and the yarn mainly used for the outer surface not directly contacting the skin are separated, and the knitting method is plain weave, Rubber knitting or pearl knitting can be selected arbitrarily. The surface in contact with the skin imparts an effect of soothing itching, which is the object of the present invention, and the outer surface moderately tightens the therapeutic aid so that it closely adheres to the skin, and further imparts functions such as heat retention and color. .

For the surface in contact with the skin, a thread carrying a metal phthalocyanine derivative having an action of soothing itching is used as a part or all of the thread. The material is cotton, rayon,
It is linen, wool, silk, polyamide, etc. Considering that the place to use is an itchy place, cotton, rayon,
It is particularly preferable to use natural fibers such as hemp, wool and silk.

The metal phthalocyanine derivative has an antipruritic / antipruritic effect [JP-A-5-58897], and an antipruritic / antipruritic fiber [2001-3034] carrying this on a fiber.
No. 37] is known. However, the metal phthalocyanine derivative is colored blue, and the yarn carrying the metal phthalocyanine derivative is also colored, so that its appearance cannot be satisfied by everyone. Therefore, in the present invention, at least the surface in contact with the skin includes a thread carrying a metal phthalocyanine derivative,
The outer surface is characterized by being knitted in a double structure using another thread. Needless to say, the effect of soothing the itch of the present invention can be utilized even when the thread carrying the metal phthalocyanine derivative on the outer side is also used.

The metal phthalocyanine derivative used in the present invention is the compound represented by the above formula (I). R in the formula
Is a carboxyl group, a sulfonic acid group, or a water-soluble base thereof, and n is 1 or 2 in the number of R. M in the formula is iron (Fe), cobalt (Co), manganese (Mn), titanium (Ti), vanadium (V), nickel (Ni), copper (Cu), zinc (Zn), molybdenum (Mo). , A metal selected from tungsten (W). Specific examples of preferred metal phthalocyanine derivatives include iron phthalocyanine tetracarboxylic acid, iron phthalocyanine polycarboxylic acid such as iron phthalocyanine octacarboxylic acid, cobalt phthalocyanine tetracarboxylic acid,
A cobalt phthalocyanine polycarboxylic acid such as cobalt phthalocyanine octacarboxylic acid, iron phthalocyanine tetrasulfonic acid, cobalt phthalocyanine tetrasulfonic acid, or a water-soluble salt thereof.

The method for producing the metal phthalocyanine derivative is as follows:
Detailed description will be omitted because it is already known in this field, but when iron phthalocyanine tetracarboxylic acid is taken as an example, trimellitic acid anhydride, urea, ammonium molybdate, and ferric chloride anhydride are used as organic solvents. The reaction is carried out by heating in a medium and then hydrolyzed to give an iron phthalocyanine tetracarboxylic acid [see JP-A-5-58897]. Similarly, iron phthalocyanine octacarboxylic acid can be obtained by using pyromellitic anhydride anhydride instead of trimellitic anhydride.

In the method of supporting a metal phthalocyanine derivative on a fiber material, typically, the material is treated with a cationizing agent, and then the metal phthalocyanine derivative is allowed to act. A cationizing agent is a compound that has a hydroxyl group or an amino group-reactive group in the molecule and a quaternary ammonium salt cation group, and reacts with the hydroxyl group or amino group in the material to form a cationic seat in the material. Is what makes
For example, there are 2,3-epoxypropyltrimethylammonium chloride, 3-chloro-2-hydroxypropyltrimethylammonium chloride and the like, “SY-GTA80” of Sakamoto Yakuhin Kogyo Co., Ltd.
"Cationon-UK", Nagase Chemtex Co., Ltd. ""
Weistex N-50] "Weistex E-10
0 ”, Lion Corporation“ Catiomaster C ”, Dainichiseika Ltd.“ KS Effector ”and the like are commercially available. The incorporation of the cationizing agent into the fiber can be achieved by adding the fiber and the cationizing agent to an alkaline aqueous solution such as sodium hydroxide and treating at 80 to 100 ° C. for 30 to 60 minutes.

Next, the fiber having the cation seats is immersed in an aqueous solution containing a metal phthalocyanine derivative and treated at 80 to 100 ° C. for 30 to 60 minutes, so that the metal phthalocyanine derivative can be supported in the fiber.
It is convenient to carry the metal phthalocyanine derivative in the shape of a thread on the thread used for the treatment aid, but it is also possible to use the cotton state before forming the thread. The amount of the metal phthalocyanine derivative supported in the fiber is not particularly limited, but is usually about 0.2 to 1.0% by weight based on the fiber.

In the treatment aid of the present invention, at least the surface that comes into contact with the skin is made of a cloth knitted with a thread carrying the metal phthalocyanine derivative. At this time, it may be knitted only with a thread carrying a metal phthalocyanine derivative, or may be knitted with a thread obtained by mixing fibers carrying a metal phthalocyanine derivative and fibers not carrying a metal phthalocyanine derivative, or with a thread carrying a metal phthalocyanine derivative. It is also possible to make a knitted fabric by mixing yarns that do not carry a metal phthalocyanine derivative. In any case, it is preferable that the concentration of the metal phthalocyanine derivative is 0.2% by weight or more in the dough in order to sooth the itch.

On the other hand, the outer surface of the treatment aid of the present invention is a surface that does not come into direct contact with the skin and does not need to contain a metal phthalocyanine derivative. The outer surface provides the power to properly tighten the treatment aid so that it is in close contact with the skin, and also retains heat,
It imparts functions such as color, and its material is arbitrarily selected from a wide range of materials such as synthetic fibers such as polyester, polyamide, polyacrylonitrile and polyurethane, and natural fibers such as cotton, rayon, hemp, wool and silk.

[0019]

[Example] [Example-1] The treatment aid of the present invention in the form of a tubular supporter was applied to 19 severely itchy areas, targeting 19 children / adults with atopic dermatitis who meet the diagnostic criteria of the Japanese Dermatological Association. I put it on. The treatment aid is a knit product knitted in a double structure with a cotton thread carrying 0.5% by weight of metal phthalocyanine tetracarboxylic acid on the inside and a polyurethane fiber on the outside. Treatment with the drug for each patient continued the same as before the start of the study, and new treatment was withheld during the study. After 4 weeks, 12 of them improved, and the details are shown in Table 1. Here, the improvement of the itch was judged by the patient himself, and other factors such as scratches, dry skin, erythema / edema, swelling / small blisters, and lichenification / pruritic nodules were determined by the doctor.

[0020]

[Table 1]

19 cases of itching, scratches,
For dry skin and eczema, those with a severe degree were scored as "4", those with a mild degree as "1", and before wearing, 2
The scores after four weeks were totaled. The results are shown in Fig. 1. In FIG. 1, the number of each score was statistically processed, and the significant difference was examined by the F distribution test method. From this result, itching,
Regarding scratches, eczema, and dry skin, there was a significant difference before and 2 weeks after wearing, and improvement was observed.

[Example-2] A 20-year-old man who had been diagnosed with atopic dermatitis and is currently being treated with a topical steroid drug was equipped with the therapeutic aid of the present invention.
The treatment aid consists of a knit product with a double structure in which a cotton thread carrying 0.5% by weight of the same metal phthalocyanine tetracarboxylic acid as the above is knitted inside and a polyurethane fiber is arranged outside, and it is attached to the itchy upper limbs. did. After continuing to wear it for two weeks, itching decreased, scratches decreased, and scratches healed.

[Example-3] [0023] A 37-year-old woman who had been diagnosed with atopic dermatitis for 23 years and is currently treated with a topical steroid drug and a moisturizer was equipped with the therapeutic aid of the present invention. When the same treatment aid as the above was applied to the inflamed upper left limb for two weeks, itching was reduced, scratches and dry skin were improved, and there was a significant difference from the similarly inflamed upper right limb. Next, when the treatment aid of the present invention was attached to the upper right limb and two weeks passed, improvement was also observed in the upper right limb and the significant difference between the left and right disappeared.

[0024]

EFFECTS OF THE INVENTION The treatment aid of the present invention subsides pruritus, which reduces patient scratching,
Inflammation such as wounds and swelling can also be relieved. This not only reduces the discomfort of itching but also enhances the therapeutic effect on inflammation, which is a good news for patients with itchy inflammation such as atopic dermatitis.

[Brief description of drawings]

BRIEF DESCRIPTION OF THE FIGURES Figure 1: 19 cases of itching, scratches, dry skin tested
With regard to eczema, the scores before, 2 weeks, and 4 weeks after the attachment are tabulated.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) D04B 21/00 D04B 21/00 B D06M 13/352 D06M 13/352 13/463 13/463 (71) Application People 591188217 Masataka Kamimura Nakamaruko, Marugo-cho, Oka-gun, Nagano 994 (72) Inventor Atsushi Komiyayama 31-11, Ojira, Matsumoto-shi, Nagano (72) Inventor Shirai, Nagase Nagase Prefecture (72) Inventor Tokuji Yokozeki 1-15-25 Chuonishi, Ueda City, Nagano Prefecture (72) Inventor Masataka Kamimura 994 F term, Nakamaruko, Maruko-machi, Ogo-gun, Nagano Prefecture (reference) 4C076 AA71 BB31 CC04 CC18 EE13 EE31 EE41 4C086 AA01 DA38 MA02 MA05 MA63 NA10 ZA89 4L002 AA00 AA01 AA02 AA03 AA05 AA06 AC00 BB01 EA00 FA00 FA06 4L033 AA02 AA03 AA08 AB06 AC10 BA56 BA86 DA07

Claims (3)

[Claims] 1. A therapeutic aid for soothing itch by adhering to itchy and inflamed skin, wherein the inner surface in contact with the skin is of formula (I) [wherein R is a carboxyl group, a sulfonic acid group,
Alternatively, it is a group selected from these water-soluble bases, and n
Is the number of R, 1 or 2, M is iron (Fe), cobalt (Co), manganese (Mn), titanium (Ti), vanadium (V), nickel (Ni), copper (Cu), zinc (Z).
n), molybdenum (Mo), or tungsten (W)], the outer surface of which is knitted into a double structure including a thread supporting a metal phthalocyanine derivative and an outer surface of which is a thread not supporting the metal phthalocyanine derivative. A therapeutic aid characterized by being configured. [Chemical 1] 2. The metal phthalocyanine derivative is one or more selected from iron phthalocyanine polycarboxylic acid, iron phthalocyanine polysulfonic acid, cobalt phthalocyanine polycarboxylic acid, cobalt phthalocyanine polysulfonic acid, and water-soluble salts thereof. The treatment aid according to claim 1. 3. A thread carrying a metal phthalocyanine derivative is prepared by treating one or more materials selected from cotton, rayon, hemp, wool, silk and polyamide with a cationizing agent, and then allowing the metal phthalocyanine derivative to act and carry it. The treatment aid according to claim 1, wherein