ES8104791A1 - Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos - Google Patents
Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicosInfo
- Publication number
- ES8104791A1 ES8104791A1 ES493301A ES493301A ES8104791A1 ES 8104791 A1 ES8104791 A1 ES 8104791A1 ES 493301 A ES493301 A ES 493301A ES 493301 A ES493301 A ES 493301A ES 8104791 A1 ES8104791 A1 ES 8104791A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- amides
- bis
- amino
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002872 contrast media Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 MONO-O Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000006698 hydrazinolysis reaction Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 210000001635 urinary tract Anatomy 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Dental Preparations (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Steroid Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE BIS-AMIDAS DE ACIDOS 5-AMINO-2-4,6-TRIYODO-ISOFTALICOS, DE FORMULA GENERAL (I). CONSISTENTE EN SOMETER A LA HIDRAZINOLISIS A UN COMPUESTO DE PARTIDA DE FORMULA GENERAL (II), EN CUYA FORMULA, ASI COMO E LA (I), X SIGNIFICA UN RADICAL ALCOHILENO INFERIOR; R1 SIGNIFICA UN HIDROGENO O UN RADICAL ALCOHILO INFERIOR; R2, R3, R4 Y R6 SIGNIFICAN HIDROGENO O RADICAL ALCOHILO INFERIOR EVENTUALMENTE HIDROXILADO; R5 SIGNIFICA UN RADICAL MONO-O POLI-HIDROXIALCOHILO, Y R7, SIGNIFICA UN RADICAL MONI-O POLI-HIDROXIALCOHILO Y SUS SALES CON ACIDOS DE AGENTES DE CONTRASTE. SE UTILIZAN COMO SOLUCIONES DE AGENTES DE CONTRASTE, PARA LA TOTAL REPRESENTACION POR RAYOS X DE, POR EJEMPLO, PARTES ESENCIALES DEL SISTEMA VASCULAR O DE LAS VIAS URINARIAS EFERENTES. *FORMULA* O
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792928417 DE2928417A1 (de) | 1979-07-12 | 1979-07-12 | Trijodierte basen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES493301A0 ES493301A0 (es) | 1981-05-16 |
| ES8104791A1 true ES8104791A1 (es) | 1981-05-16 |
Family
ID=6075678
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493301A Expired ES8104791A1 (es) | 1979-07-12 | 1980-07-11 | Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos |
| ES493302A Granted ES493302A0 (es) | 1979-07-12 | 1980-07-11 | Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493302A Granted ES493302A0 (es) | 1979-07-12 | 1980-07-11 | Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4283381A (es) |
| EP (1) | EP0022744B1 (es) |
| JP (1) | JPS5659717A (es) |
| AT (1) | ATE2834T1 (es) |
| AU (1) | AU536426B2 (es) |
| CA (1) | CA1129438A (es) |
| CS (1) | CS214834B2 (es) |
| DE (2) | DE2928417A1 (es) |
| DK (1) | DK154501C (es) |
| EG (1) | EG14884A (es) |
| ES (2) | ES8104791A1 (es) |
| FI (1) | FI68042C (es) |
| GR (1) | GR69303B (es) |
| HU (1) | HU182154B (es) |
| IE (1) | IE50064B1 (es) |
| IL (1) | IL60517A (es) |
| NO (1) | NO150719C (es) |
| PH (1) | PH16651A (es) |
| PT (1) | PT71547A (es) |
| YU (1) | YU177980A (es) |
| ZA (1) | ZA804192B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3038853A1 (de) | 1980-10-10 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii) |
| DE3150917A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung" |
| FR2541676A1 (fr) * | 1983-02-25 | 1984-08-31 | Guerbet Sa | Composes non-ioniques a structures benzenique iodee ou bromee et produits opacifiants en contenant |
| GB8906130D0 (en) * | 1989-03-17 | 1989-05-04 | Nycomed As | Compositions |
| US5232685A (en) * | 1989-11-03 | 1993-08-03 | Schering Aktiengesellschaft | Nonionic x-ray contrast medium with high iodine content |
| CA2029830A1 (en) * | 1989-11-29 | 1991-05-30 | Ramachandran S. Ranganathan | Nonionic radiographic contrast agents |
| US5614638A (en) * | 1989-11-29 | 1997-03-25 | Bracco International B.V. | Nonionic radiographic contrast agents |
| GB9020091D0 (en) * | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
| US5278311A (en) * | 1992-06-05 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Nonionic radiographic contrast agents |
| ES2135086T3 (es) * | 1994-09-22 | 1999-10-16 | Guerbet Sa | Compuestos poliyodados, su preparacion, y su aplicacion en radiologia. |
| IT1299202B1 (it) * | 1998-05-08 | 2000-02-29 | Dibra Spa | Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo |
| IT1312569B1 (it) * | 1999-05-21 | 2002-04-22 | Raffaele Ansovini | Uso dell'enzima gssg reduttasi per il trattamento terapeutico e laprofilassi di pazienti infettati da hiv. |
| US7790141B2 (en) * | 2003-08-11 | 2010-09-07 | Pathak Holdings, Llc | Radio-opaque compounds, compositions containing same and methods of their synthesis and use |
| CN101654417B (zh) * | 2009-09-01 | 2012-06-20 | 江苏省原子医学研究所 | X线造影剂碘佛醇中间体的制备方法 |
| CN105461581A (zh) * | 2015-11-17 | 2016-04-06 | 浙江海洲制药有限公司 | 碘帕醇杂质a和杂质b的合成方法 |
| CN115806498B (zh) * | 2021-09-15 | 2024-09-10 | 大道隆达（北京）医药科技发展有限公司 | 5-氯乙酰胺基-2,4,6-三碘异酞酰氯的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2776241A (en) * | 1952-08-06 | 1957-01-01 | Schering Ag | Injectable x-ray contrast agents comprising salts of n-acyl derivatives of 2, 4, 6-triiodo-3-aminobenzoic acid |
| US3178473A (en) * | 1962-03-02 | 1965-04-13 | Nyegaard & Co As | Process for the n-alkylation of acyl anilides halogen substituted in the nucleus |
| US4021481A (en) * | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
| FR2053037B1 (es) * | 1969-06-27 | 1974-08-09 | Nyegaard & Co As | |
| BE795555A (fr) * | 1972-02-16 | 1973-08-16 | Schering Ag | Amides de triiodo-isophtaloyl-monoamino-acide, leur procede de preparation et leur utilisation |
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| US4192859A (en) * | 1978-09-29 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Contrast media containing liposomes as carriers |
-
1979
- 1979-07-12 DE DE19792928417 patent/DE2928417A1/de not_active Withdrawn
-
1980
- 1980-06-27 AT AT80730043T patent/ATE2834T1/de not_active IP Right Cessation
- 1980-06-27 DE DE8080730043T patent/DE3062428D1/de not_active Expired
- 1980-06-27 EP EP80730043A patent/EP0022744B1/de not_active Expired
- 1980-07-08 IL IL60517A patent/IL60517A/xx unknown
- 1980-07-10 CA CA355,900A patent/CA1129438A/en not_active Expired
- 1980-07-10 GR GR62426A patent/GR69303B/el unknown
- 1980-07-10 FI FI802215A patent/FI68042C/fi not_active IP Right Cessation
- 1980-07-10 AU AU60294/80A patent/AU536426B2/en not_active Ceased
- 1980-07-10 YU YU01779/80A patent/YU177980A/xx unknown
- 1980-07-10 CS CS804924A patent/CS214834B2/cs unknown
- 1980-07-10 PH PH24273A patent/PH16651A/en unknown
- 1980-07-11 NO NO802102A patent/NO150719C/no unknown
- 1980-07-11 JP JP9406480A patent/JPS5659717A/ja active Pending
- 1980-07-11 ES ES493301A patent/ES8104791A1/es not_active Expired
- 1980-07-11 HU HU801748A patent/HU182154B/hu unknown
- 1980-07-11 PT PT71547A patent/PT71547A/pt unknown
- 1980-07-11 DK DK300680A patent/DK154501C/da not_active IP Right Cessation
- 1980-07-11 ZA ZA00804192A patent/ZA804192B/xx unknown
- 1980-07-11 US US06/167,597 patent/US4283381A/en not_active Expired - Lifetime
- 1980-07-11 ES ES493302A patent/ES493302A0/es active Granted
- 1980-07-11 IE IE1441/80A patent/IE50064B1/en unknown
- 1980-07-12 EG EG412/80A patent/EG14884A/xx active
Also Published As
| Publication number | Publication date |
|---|---|
| FI68042B (fi) | 1985-03-29 |
| DE2928417A1 (de) | 1981-01-29 |
| FI68042C (fi) | 1985-07-10 |
| ES8104792A1 (es) | 1981-05-16 |
| JPS5659717A (en) | 1981-05-23 |
| GR69303B (es) | 1982-05-14 |
| ES493301A0 (es) | 1981-05-16 |
| EP0022744A3 (en) | 1981-03-11 |
| ATE2834T1 (de) | 1983-04-15 |
| NO802102L (no) | 1981-01-13 |
| NO150719B (no) | 1984-08-27 |
| DK154501C (da) | 1989-04-10 |
| CA1129438A (en) | 1982-08-10 |
| US4283381A (en) | 1981-08-11 |
| DK300680A (da) | 1981-01-13 |
| EP0022744A2 (de) | 1981-01-21 |
| EP0022744B1 (de) | 1983-03-23 |
| ZA804192B (en) | 1981-07-29 |
| CS214834B2 (en) | 1982-06-25 |
| EG14884A (en) | 1985-06-30 |
| PH16651A (en) | 1983-12-06 |
| HU182154B (en) | 1983-12-28 |
| AU6029480A (en) | 1981-01-15 |
| DK154501B (da) | 1988-11-21 |
| IE50064B1 (en) | 1986-02-05 |
| IL60517A0 (en) | 1980-09-16 |
| ES493302A0 (es) | 1981-05-16 |
| PT71547A (en) | 1980-08-01 |
| YU177980A (en) | 1983-12-31 |
| DE3062428D1 (en) | 1983-04-28 |
| IE801441L (en) | 1981-01-12 |
| NO150719C (no) | 1984-12-05 |
| IL60517A (en) | 1984-06-29 |
| AU536426B2 (en) | 1984-05-10 |
| FI802215A7 (fi) | 1981-01-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8104791A1 (es) | Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos | |
| ES2059557T3 (es) | Nuevas bis-(3,5-dicarbamoil-2,4,6-triyodo-anilidas) de acidos dicarboxilicos, procedimiento para su preparacion asi como agentes de contraste de rayos x que contienen a estos. | |
| ES8802227A1 (es) | Procedimiento de obtencion de derivados de mitomicina. | |
| ES498252A0 (es) | Procedimiento para la preparacion de derivados no ionicos deacidos 2,4,6-triyodo-isoftalico substituidos en 5-c | |
| ES2052166T3 (es) | Derivados de 24-homo-vitamina-d, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos. | |
| ES463408A1 (es) | Procedimiento para la preparacion de nuevas fluoracil-resor-cinas sustituidas. | |
| ES465527A1 (es) | Procedimiento para la obtencion de nuevas feniletilaminas. | |
| SE8604950L (sv) | Demensforbettrande och terapeutiska medel | |
| ES2054650T3 (es) | Fenilacetonitrilos basicamente substituidos, su obtencion y medicamentos que los contienen. | |
| ES8706692A1 (es) | Un metodo para preparar nuevos derivados de cefem | |
| ES8303427A1 (es) | "un procedimiento para preparar compuestos de cefem". | |
| ES8304966A1 (es) | Un procediemento para la preparacion de un derivado de piridoindol. | |
| SE7902866L (sv) | 3-0-(beta-d-glukuronopyranosyl)-sojasapogenol b | |
| ES471254A1 (es) | Procedimiento para la preparacion de nuevas imidazo-isoqui- nolein-dionas | |
| ES516888A0 (es) | Procedimiento para la obtencion de esteres sustituidos de tiazolidimilos de acidos minerales. | |
| ES485733A1 (es) | Procedimiento para la obtencion de derivados de esteres de 1,1,2-trifenilalqueno | |
| ES517425A0 (es) | Procedimiento para la preparacion de bis-betainas. | |
| SE7708060L (sv) | Antracykliner | |
| ES8504116A1 (es) | Procedimiento para preparar nuevos (3.2.0.) bicicloheptanonoxim-eteres | |
| FR2442829A1 (fr) | Esters d'acide farnesylacetique et leur utilisation comme agents anti-ulcereux | |
| ES8201530A1 (es) | Procedimiento de preparar cicloalquil propanol aminas | |
| ES8306467A1 (es) | Procedimiento para la preparacion de alfa-hidroxiacidos. | |
| ES2063305T3 (es) | Derivados de bifenilo, procedimiento para la preparacion de los mismos e intermedios para los mismos. | |
| AR245930A1 (es) | Un nuevo procedimiento quimico para la sintesis de la n-metil-3,4-dimetoxifeniletilamina. | |
| CH611604A5 (en) | Process for the preparation of an 8-azaprostaglandin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000201 |