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EE200200576A - Oksasooli derivaadid ja nende kasutamine türosiini kinaasi inhibiitoritena - Google Patents

Oksasooli derivaadid ja nende kasutamine türosiini kinaasi inhibiitoritena

Info

Publication number
EE200200576A
EE200200576A EEP200200576A EEP200200576A EE200200576A EE 200200576 A EE200200576 A EE 200200576A EE P200200576 A EEP200200576 A EE P200200576A EE P200200576 A EEP200200576 A EE P200200576A EE 200200576 A EE200200576 A EE 200200576A
Authority
EE
Estonia
Prior art keywords
tyrosine kinase
kinase inhibitors
oxazole derivatives
oxazole
derivatives
Prior art date
Application number
EEP200200576A
Other languages
English (en)
Estonian (et)
Inventor
Tasaka Akihiro
Hitaka Takenori
Matsutani Etsuya
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of EE200200576A publication Critical patent/EE200200576A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200200576A 2000-04-07 2001-04-05 Oksasooli derivaadid ja nende kasutamine türosiini kinaasi inhibiitoritena EE200200576A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000106836 2000-04-07
PCT/JP2001/002937 WO2001077107A1 (en) 2000-04-07 2001-04-05 Oxazole derivatives and their uses as tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
EE200200576A true EE200200576A (et) 2004-06-15

Family

ID=18619943

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200576A EE200200576A (et) 2000-04-07 2001-04-05 Oksasooli derivaadid ja nende kasutamine türosiini kinaasi inhibiitoritena

Country Status (19)

Country Link
US (2) US6716863B2 (xx)
EP (1) EP1268473A1 (xx)
KR (1) KR20020028865A (xx)
CN (1) CN1444582A (xx)
AU (1) AU2001244726A1 (xx)
BR (1) BR0109851A (xx)
CA (1) CA2404760A1 (xx)
CO (1) CO5261589A1 (xx)
CZ (1) CZ20023264A3 (xx)
EE (1) EE200200576A (xx)
HU (1) HUP0300434A3 (xx)
IL (1) IL152115A0 (xx)
MX (1) MXPA02009621A (xx)
NO (1) NO20024742L (xx)
OA (1) OA12244A (xx)
PE (1) PE20011178A1 (xx)
PL (1) PL365787A1 (xx)
SK (1) SK14132002A3 (xx)
WO (1) WO2001077107A1 (xx)

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EP1136079A4 (en) * 1998-10-08 2004-09-22 Takeda Chemical Industries Ltd AGENTS FOR DELAYING THE TRANSFER FROM HORMONO-DEPENDENT CANCER TO HORMONO-INDEPENDENT CANCER
AU2001271058A1 (en) * 2000-07-19 2002-01-30 Takeda Chemical Industries Ltd. Method for producing 1-substituted-1,2,3-triazole derivative
EP1382350A4 (en) * 2001-04-25 2006-01-04 Takeda Pharmaceutical MEANS AGAINST THE PROPHYLAXIS BEFORE POSTOPERATIVE REPEAT OF PREMOPEOPAUSAL BREAST CANCER
US20040116330A1 (en) * 2001-04-27 2004-06-17 Kenichiro Naito Preventive/therapeutic method for cancer
WO2002087619A1 (fr) * 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Methode de prevention et de traitement du cancer
JP2003137814A (ja) * 2001-08-10 2003-05-14 Takeda Chem Ind Ltd ＧｎＲＨアゴニストの併用剤
EP1439178A4 (en) * 2001-10-05 2005-11-16 Takeda Pharmaceutical Heterocyclic compounds, oxazole derivatives, process for their preparation and their use
WO2003041739A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticaner agents
AU2002349477A1 (en) * 2001-11-26 2003-06-10 Takeda Chemical Industries, Ltd. Bicyclic derivative, process for producing the same, and use
AU2003203170A1 (en) * 2002-01-17 2003-07-30 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
EP1572083A4 (en) 2002-04-25 2008-09-24 Univ Connecticut Health Ct USE OF THERMAL SHOCK PROTEINS TO IMPROVE THE THERAPEUTIC ADVANTAGE OF NON-VACCINAL TREATMENT MODALITY
CN100339078C (zh) * 2002-12-16 2007-09-26 橘生药品工业株式会社 固体口服剂型药物
TW200505913A (en) 2003-03-28 2005-02-16 Hoffmann La Roche Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
AR044098A1 (es) 2003-04-30 2005-08-24 Hoffmann La Roche Derivados de anilina, su elaboracion, composiciones farmaceuticas y su uso para elaborar medicamentos para el tratamiento del cancer
US7247649B2 (en) 2003-08-13 2007-07-24 Hoffmann-La Roche Inc. Oxazoles, their manufacture and use as pharmaceutical agents
US7259262B2 (en) * 2003-10-24 2007-08-21 Hoffmann-La Roche Inc. Arylazole derivatives, their manufacture and use as pharmaceutical agents
US20050186275A1 (en) * 2004-02-23 2005-08-25 Standard Chem. & Pharm. Co. Ltd. Sustained release tamsulosin formulations
TW200612914A (en) 2004-03-05 2006-05-01 Hoffmann La Roche Novel oxidized thioether derivatives, their manufacture and use as pharmaceutical agents
TW200531688A (en) 2004-03-05 2005-10-01 Hoffmann La Roche Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
TW200533346A (en) 2004-03-18 2005-10-16 Hoffmann La Roche Novel ether derivatives, their manufacture and use as pharmaceutical agents
RU2006138424A (ru) 2004-04-02 2008-05-10 Ф.Хоффманн-Ля Рош Аг (Ch) Новые производные диазина, их получение и применение в качестве фармацевтических агентов
US7005526B2 (en) 2004-05-25 2006-02-28 Hoffmann-La Roche Inc. Thioether derivatives
US7163953B2 (en) * 2004-05-25 2007-01-16 Hoffmann-La Roche Inc. Benzylether derivatives
US7618769B2 (en) * 2004-06-07 2009-11-17 Applied Materials, Inc. Textured chamber surface
US7288557B2 (en) 2004-09-21 2007-10-30 Hoffmann-La Roche Inc. Triazole derivatives
AR050944A1 (es) * 2004-09-22 2006-12-06 Hoffmann La Roche Derivados de indol, su fabricacion y su utilizacion como agentes farmaceuticos
AR050652A1 (es) * 2004-09-24 2006-11-08 Hoffmann La Roche Derivados de oxazol, preparacion y uso como inhibidores de la tirosina quinasa
US20060116407A1 (en) * 2004-11-22 2006-06-01 Birgit Bossenmaier Amide derivatives
TW200727900A (en) * 2005-07-27 2007-08-01 Yakult Honsha Kk Aqueous solution preparation containing camptothecins
TW200738680A (en) 2005-08-04 2007-10-16 Hoffmann La Roche Phenylpyridine derivatives, their manufacture and use as pharmaceutical agents
JP2009504586A (ja) * 2005-08-08 2009-02-05 エフ．ホフマン−ラ ロシュ アーゲー ピラゾール誘導体、それらの製造及び医薬品としての使用
CN101233130A (zh) * 2005-09-30 2008-07-30 霍夫曼-拉罗奇有限公司 二嗪唑衍生物，它们的制备和作为药剂的应用
WO2008034579A1 (en) * 2006-09-20 2008-03-27 F. Hoffmann-La Roche Ag 2-heterocyclyl-5-phenoxymethylpyridine derivatives as anticancer agents
EP2103620A1 (en) 2006-12-12 2009-09-23 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
WO2008133102A1 (ja) 2007-04-20 2008-11-06 Daido Chemical Corporation 新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物
TW200944528A (en) 2008-03-12 2009-11-01 Takeda Pharmaceutical Fused heterocyclic compound
AR073679A1 (es) * 2008-09-26 2010-11-24 Takeda Pharmaceutical Prevencion y tratamiento de cancer con la no expresion de lkb1 supresion o mutacion, composicion farmaceutica. usos
TW201016704A (en) * 2008-09-26 2010-05-01 Takeda Pharmaceutical Prevention and treatment of cancer with RAS gene mutation
US9023398B2 (en) 2009-09-30 2015-05-05 Kabushiki Kaisha Sangi Method for improving the aqueous solubility of poorly-soluble substances
WO2011105534A1 (ja) 2010-02-26 2011-09-01 日新化成株式会社 硬カプセルおよびその製造方法
WO2011153050A1 (en) 2010-06-02 2011-12-08 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to her2/neu receptor complex
US8993634B2 (en) 2010-06-02 2015-03-31 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to Her2/neu receptor complex
JP5909796B2 (ja) 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
JP6225113B2 (ja) 2012-09-26 2017-11-01 武田薬品工業株式会社 固体粒子の製造方法
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
JP6914860B2 (ja) 2015-07-01 2021-08-04 カリフォルニア インスティチュート オブ テクノロジー カチオン性粘液酸ポリマー系デリバリーシステム
EP3238711B1 (en) 2016-04-26 2023-07-12 Mitsubishi Chemical Corporation Base for solid dispersion, production method for solid dispersion using same, and solid dispersion
CA2995617A1 (en) * 2017-11-03 2019-05-03 Universite De Montreal Heterocyclic mitochondrial activity inhibitors and uses thereof
EP3806887A4 (en) 2018-06-13 2022-04-06 California Institute of Technology Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
JPWO2020130125A1 (ja) 2018-12-21 2021-11-04 第一三共株式会社 抗体−薬物コンジュゲートとキナーゼ阻害剤の組み合わせ
CN114981298B (zh) 2019-12-12 2024-08-20 听治疗有限责任公司 用于预防和治疗听力损失的组合物和方法
CN114217025B (zh) * 2021-12-17 2024-01-23 哈尔滨工业大学 评估空气质量浓度预测中气象数据对其影响的分析方法

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Publication number Priority date Publication date Assignee Title
IL97872A (en) 1990-04-16 1996-07-23 Rhone Poulenc Rorer Int Pharmaceutical compositions containing styryl-substituted monocylic and bicyclic heteroaryl compounds which inhibit egf receptor tyrosine kinase and a compounds of this type
CN1077107C (zh) * 1996-07-19 2002-01-02 武田药品工业株式会社 杂环化合物、其制备和用途

Also Published As

Publication number Publication date
CZ20023264A3 (cs) 2003-02-12
PE20011178A1 (es) 2001-11-19
PL365787A1 (en) 2005-01-10
WO2001077107B1 (en) 2001-12-20
AU2001244726A1 (en) 2001-10-23
MXPA02009621A (es) 2003-05-14
CO5261589A1 (es) 2003-03-31
HUP0300434A3 (en) 2004-11-29
KR20020028865A (ko) 2002-04-17
NO20024742D0 (no) 2002-10-02
CA2404760A1 (en) 2001-10-18
HUP0300434A2 (hu) 2003-06-28
OA12244A (en) 2006-05-10
US6716863B2 (en) 2004-04-06
US20040024035A1 (en) 2004-02-05
CN1444582A (zh) 2003-09-24
US20020173526A1 (en) 2002-11-21
NO20024742L (no) 2002-11-25
IL152115A0 (en) 2003-05-29
BR0109851A (pt) 2003-06-03
SK14132002A3 (sk) 2003-04-01
WO2001077107A1 (en) 2001-10-18
EP1268473A1 (en) 2003-01-02
WO2001077107A8 (en) 2003-02-13

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