EE05085B1 - Pridiin-1-oksiidderivaat ja meetod selle muutmiseks farmatseutiliselt efektiivseteks henditeks - Google Patents

Pridiin-1-oksiidderivaat ja meetod selle muutmiseks farmatseutiliselt efektiivseteks henditeks

Info

Publication number: EE05085B1
Authority: EE; Estonia
Prior art keywords: rhodine; converting; pharmaceutically effective; oxide; oxide derivative
Prior art date: 2000-04-18

Application number

EEP200200591A

Other languages

English (en)

Estonian (et)

Inventor

βszl� �r�gdi L

Jegesn� Cs βkai Zita

Gruber Lajos

βszl� �tv�s L

T�th J�zsef

βn T�m�sk�zi Istv

Szak βcsn� Schmidt Anik�

Reider Ferencn�

βria Schneidern� Barlay M

Original Assignee

Biorex Kutat� �s Fejleszto Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-18

Filing date

2001-04-17

Publication date

2008-10-15

2001-04-17 Application filed by Biorex Kutat� �s Fejleszto Rt. filed Critical Biorex Kutat� �s Fejleszto Rt.

2004-04-15 Publication of EE200200591A publication Critical patent/EE200200591A/xx

2008-10-15 Publication of EE05085B1 publication Critical patent/EE05085B1/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
QPANXJTVLHTKCV-UHFFFAOYSA-N n'-(2-hydroxy-3-piperidin-1-ylpropoxy)-1-oxidopyridin-1-ium-3-carboximidamide Chemical compound C=1C=C[N+]([O-])=CC=1C(N)=NOCC(O)CN1CCCCC1 QPANXJTVLHTKCV-UHFFFAOYSA-N 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EEP200200591A 2000-04-18 2001-04-17 Pridiin-1-oksiidderivaat ja meetod selle muutmiseks farmatseutiliselt efektiivseteks henditeks EE05085B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0001583A HUP0001583A2 (hu)	2000-04-18	2000-04-18	Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
PCT/HU2001/000046 WO2001079174A1 (en)	2000-04-18	2001-04-17	A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds

Publications (2)

Publication Number	Publication Date
EE200200591A EE200200591A (et)	2004-04-15
EE05085B1 true EE05085B1 (et)	2008-10-15

Family

ID=90001563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200591A EE05085B1 (et)	2000-04-18	2001-04-17	Pridiin-1-oksiidderivaat ja meetod selle muutmiseks farmatseutiliselt efektiivseteks henditeks

Country Status (32)

Country	Link
US (1)	US7126002B2 (xx)
EP (1)	EP1274685B1 (xx)
JP (1)	JP5066638B2 (xx)
KR (1)	KR100742482B1 (xx)
CN (1)	CN1216868C (xx)
AT (1)	ATE332894T1 (xx)
AU (2)	AU2001254997B2 (xx)
BG (1)	BG65889B1 (xx)
BR (1)	BRPI0110184B8 (xx)
CA (1)	CA2406266C (xx)
CY (1)	CY1107473T1 (xx)
CZ (1)	CZ301576B6 (xx)
DE (1)	DE60121431T2 (xx)
DK (1)	DK1274685T3 (xx)
EE (1)	EE05085B1 (xx)
ES (1)	ES2267758T3 (xx)
HK (1)	HK1055741A1 (xx)
HR (1)	HRP20020825A2 (xx)
HU (1)	HUP0001583A2 (xx)
IL (2)	IL152337A0 (xx)
MX (1)	MXPA02010320A (xx)
NO (1)	NO323535B1 (xx)
NZ (1)	NZ522017A (xx)
PL (1)	PL359826A1 (xx)
PT (1)	PT1274685E (xx)
RS (1)	RS51003B (xx)
RU (1)	RU2281282C2 (xx)
SI (1)	SI1274685T1 (xx)
SK (1)	SK287606B6 (xx)
UA (1)	UA75353C2 (xx)
WO (1)	WO2001079174A1 (xx)
ZA (1)	ZA200208460B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP9900475D0 (en) *	1999-02-26	1999-04-28	Biorex Kutato Fejlesztoe Kft	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
HU0103939D0 (en) *	2001-09-27	2001-11-28	Biorex Kutato Fejlesztoe Kft	Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
BR0306778A (pt)	2002-01-11	2004-12-28	Biorex Kutato Fejlesztoe Kft	Derivados de carboxamidina e seu uso no tratamento de doenças vasculares
HUP0303584A3 (en)	2003-10-30	2009-12-28	Cytrx Corp	Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) *	2006-09-26	2008-08-01	Cytrx Corp	Pharmaceutical compositions and methods for treating diseases
WO2009155936A1 (en)	2008-06-26	2009-12-30	Orphazyme Aps	Use of hsp70 as a regulator of enzymatic activity
BR112013013143A2 (pt)	2010-11-30	2016-08-23	Orphazyme Aps	composto, e, método de tratamento de uma doença de armazenagem lisossômica
HUP1100535A2 (en)	2011-09-26	2013-04-29	Bracelia Invest Ltd	Pharmaceutical composition for enhancement of stem cell treatment
HUP1100534A2 (en)	2011-09-26	2013-04-29	Balazs Dr Hazay	Pharmaceutical composition for the treatment of muscle atrophy
HUE054957T2 (hu)	2014-09-15	2021-10-28	Orphazyme As	Arimoklomol készítése
EP3442530A1 (en)	2016-04-13	2019-02-20	Orphazyme A/S	Heat shock proteins and cholesterol homeostasis
DK3448382T3 (da)	2016-04-29	2020-12-07	Orphazyme As	Arimoclomol til behandling af glucocerebrosidase-associerede lidelser
CN111372654A (zh)	2017-09-22	2020-07-03	阿德莱德大学	用于改善精子质量的方法和产品
HUP1800298A1 (hu)	2018-08-30	2020-05-28	N Gene Res Laboratories Inc	Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
US20230226036A1 (en)	2020-06-24	2023-07-20	Orphazyme A/S	Arimoclomol for treating gaucher disease
WO2022106614A1 (en)	2020-11-19	2022-05-27	Orphazyme A/S	Processes for preparing arimoclomol citrate and intermediates thereof
WO2022136640A1 (en)	2020-12-24	2022-06-30	Orphazyme A/S	Arimoclomol for the treatment of niemann pick disease, type c, in patients with er type missense mutations
WO2025014519A1 (en)	2023-07-10	2025-01-16	N-Gene Research Laboratories, Inc.	Increasing telomere length and/or suppressing telomere shortening

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU207988B (en) *	1988-10-20	1993-07-28	Biorex Kutato Fejlesztoe Kft	Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU9502843D0 (en)	1995-09-29	1995-11-28	Livigene Ltd	Pharmaceutical composition
HU222994B1 (hu) *	1995-11-02	2004-01-28	BIOREX Kutató és Fejlesztő Rt.	Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HUP9900475D0 (en)	1999-02-26	1999-04-28	Biorex Kutato Fejlesztoe Kft	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component

2000
- 2000-04-18 HU HU0001583A patent/HUP0001583A2/hu unknown
2001
- 2001-04-17 SI SI200130607T patent/SI1274685T1/sl unknown
- 2001-04-17 CA CA2406266A patent/CA2406266C/en not_active Expired - Lifetime
- 2001-04-17 ES ES01928133T patent/ES2267758T3/es not_active Expired - Lifetime
- 2001-04-17 EP EP01928133A patent/EP1274685B1/en not_active Expired - Lifetime
- 2001-04-17 KR KR1020027014047A patent/KR100742482B1/ko not_active Expired - Fee Related
- 2001-04-17 DE DE60121431T patent/DE60121431T2/de not_active Expired - Lifetime
- 2001-04-17 CN CN018108318A patent/CN1216868C/zh not_active Expired - Lifetime
- 2001-04-17 NZ NZ522017A patent/NZ522017A/en unknown
- 2001-04-17 PL PL35982601A patent/PL359826A1/xx not_active IP Right Cessation
- 2001-04-17 AU AU2001254997A patent/AU2001254997B2/en not_active Expired
- 2001-04-17 DK DK01928133T patent/DK1274685T3/da active
- 2001-04-17 MX MXPA02010320A patent/MXPA02010320A/es active IP Right Grant
- 2001-04-17 RU RU2002130710/04A patent/RU2281282C2/ru not_active IP Right Cessation
- 2001-04-17 UA UA2002108255A patent/UA75353C2/uk unknown
- 2001-04-17 WO PCT/HU2001/000046 patent/WO2001079174A1/en active IP Right Grant
- 2001-04-17 PT PT01928133T patent/PT1274685E/pt unknown
- 2001-04-17 CZ CZ20023445A patent/CZ301576B6/cs not_active IP Right Cessation
- 2001-04-17 JP JP2001576775A patent/JP5066638B2/ja not_active Expired - Lifetime
- 2001-04-17 EE EEP200200591A patent/EE05085B1/xx not_active IP Right Cessation
- 2001-04-17 SK SK1508-2002A patent/SK287606B6/sk not_active IP Right Cessation
- 2001-04-17 IL IL15233701A patent/IL152337A0/xx active IP Right Grant
- 2001-04-17 BR BRPI0110184A patent/BRPI0110184B8/pt not_active IP Right Cessation
- 2001-04-17 US US10/257,755 patent/US7126002B2/en not_active Expired - Lifetime
- 2001-04-17 AU AU5499701A patent/AU5499701A/xx active Pending
- 2001-04-17 AT AT01928133T patent/ATE332894T1/de not_active IP Right Cessation
- 2001-04-17 RS YUP-783/02A patent/RS51003B/sr unknown
2002
- 2002-10-16 BG BG107199A patent/BG65889B1/bg unknown
- 2002-10-16 HR HRP20020825 patent/HRP20020825A2/hr not_active Application Discontinuation
- 2002-10-17 IL IL152337A patent/IL152337A/en unknown
- 2002-10-18 NO NO20025015A patent/NO323535B1/no not_active IP Right Cessation
- 2002-10-18 ZA ZA200208460A patent/ZA200208460B/en unknown
2003
- 2003-11-10 HK HK03108135A patent/HK1055741A1/xx not_active IP Right Cessation
2006
- 2006-07-21 CY CY20061101020T patent/CY1107473T1/el unknown

Also Published As

Publication number	Publication date
KR100742482B1 (ko)	2007-07-25
AU2001254997B2 (en)	2006-11-23
PL359826A1 (en)	2004-09-06
CZ301576B6 (cs)	2010-04-21
ZA200208460B (en)	2003-10-20
DE60121431T2 (de)	2007-01-18
CN1216868C (zh)	2005-08-31
JP2004501080A (ja)	2004-01-15
NO323535B1 (no)	2007-06-04
EP1274685A1 (en)	2003-01-15
EP1274685B1 (en)	2006-07-12
CA2406266C (en)	2010-07-20
CY1107473T1 (el)	2012-12-19
CZ20023445A3 (cs)	2003-03-12
SK15082002A3 (sk)	2003-05-02
HUP0001583D0 (en)	2000-06-28
BG107199A (bg)	2003-07-31
UA75353C2 (en)	2006-04-17
RU2281282C2 (ru)	2006-08-10
HUP0001583A2 (hu)	2002-11-28
IL152337A0 (en)	2003-05-29
EE200200591A (et)	2004-04-15
RU2002130710A (ru)	2004-03-20
YU78302A (sh)	2005-09-19
MXPA02010320A (es)	2004-09-06
DE60121431D1 (de)	2006-08-24
BR0110184A (pt)	2003-06-17
CA2406266A1 (en)	2001-10-25
ATE332894T1 (de)	2006-08-15
WO2001079174A1 (en)	2001-10-25
BRPI0110184B1 (pt)	2015-12-29
BRPI0110184B8 (pt)	2021-05-25
HRP20020825A2 (en)	2004-12-31
NO20025015L (no)	2002-12-16
KR20030011309A (ko)	2003-02-07
NZ522017A (en)	2004-06-25
SI1274685T1 (sl)	2006-10-31
NO20025015D0 (no)	2002-10-18
DK1274685T3 (da)	2006-11-06
AU5499701A (en)	2001-10-30
ES2267758T3 (es)	2007-03-16
IL152337A (en)	2007-10-31
JP5066638B2 (ja)	2012-11-07
US7126002B2 (en)	2006-10-24
CN1434800A (zh)	2003-08-06
WO2001079174A8 (en)	2002-12-27
RS51003B (sr)	2010-10-31
BG65889B1 (bg)	2010-04-30
SK287606B6 (sk)	2011-03-04
PT1274685E (pt)	2006-09-29
US20040006232A1 (en)	2004-01-08
HK1055741A1 (en)	2004-01-21

Legal Events

Date	Code	Title	Description
2006-10-16	GB1A	Change in the ownership or in the address of the owner
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2011-12-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20110417

Publication	Publication Date	Title
EE05085B1 (et)	2008-10-15	Pridiin-1-oksiidderivaat ja meetod selle muutmiseks farmatseutiliselt efektiivseteks henditeks
EA200100971A1 (ru)	2002-02-28	Новые соединения и композиции в качестве ингибиторов протеазы
EE200300403A (et)	2003-12-15	N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina
EA199800290A1 (ru)	1998-10-29	(метилсульфонил) фенил-2-(5н)-фураноны в качестве ингибиторов циклооксигеназы-2
EA200300776A1 (ru)	2004-06-24	Производные фенэтаноламина для лечения респираторных заболеваний
EA200301216A1 (ru)	2004-06-24	Замещенные хинуклидинами мультициклические гетероарилы для лечения заболевания
BR0306870A (pt)	2004-11-03	Composição farmacêutica oral, e, método para preparar a mesma
EA200301223A1 (ru)	2004-08-26	Лекарственные формы окскарбазепина
IS6859A (is)	2003-06-24	Kristölluð form atorvastatíns
EA200601194A1 (ru)	2006-10-27	Новые производные бензофурана, используемые для профилактики или лечения нарушений, связанных с 5-ht-рецептором
BR0311984A (pt)	2005-04-26	Difenilazetidinonas substituìdas cationicamente, processo para a sua preparação, medicamentos contendo estes compostos e sua aplicação
SE9901077D0 (sv)	1999-03-23	Novel use
ATE253359T1 (de)	2003-11-15	Antithrombotische mittel
EA200600866A1 (ru)	2006-10-27	Применение галоидного производного гидроксимовой кислоты для лечения нейродегенеративных заболеваний
DE69917005D1 (de)	2004-06-09	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
EA200000322A1 (ru)	2000-10-30	Способ синтеза производных хинолина
EA200300771A1 (ru)	2004-02-26	Новая соль бензоилгуанидина
NO996128L (no)	1999-12-10	Nye pentaerytrittderivater, deres fremstilling og anvendelse så vel som mellomprodukter for deres syntese
SE9901340D0 (sv)	1999-04-15	Novel process
DK1075461T3 (da)	2004-12-06	Perfluorerede estere af alkanoyl-L-carnitin til fremstillingen af kationiske lipider til den intracellulære levering af farmakologisk aktive forbindelser
EA200500235A1 (ru)	2005-08-25	Новые производные пиперазинона для лечения нарушений, связанных с 5-ht-рецептором
BR9915898A (pt)	2001-08-21	Compostos, composição farmacêutica, e, utilização de um composto
SE9704835D0 (sv)	1997-12-22	New compound

EE05085B1 - Pridiin-1-oksiidderivaat ja meetod selle muutmiseks farmatseutiliselt efektiivseteks henditeks - Google Patents