EA201390639A1 - DERIVATIVES 2-PIPERAZIN-1-IL-4N-1,3-BENZOTHIAZIN-4-SHE AND THEIR APPLICATION FOR THE TREATMENT OF INFECTIONS IN MAMMALS - Google Patents
DERIVATIVES 2-PIPERAZIN-1-IL-4N-1,3-BENZOTHIAZIN-4-SHE AND THEIR APPLICATION FOR THE TREATMENT OF INFECTIONS IN MAMMALSInfo
- Publication number
- EA201390639A1 EA201390639A1 EA201390639A EA201390639A EA201390639A1 EA 201390639 A1 EA201390639 A1 EA 201390639A1 EA 201390639 A EA201390639 A EA 201390639A EA 201390639 A EA201390639 A EA 201390639A EA 201390639 A1 EA201390639 A1 EA 201390639A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- benzothiazin
- piperazin
- infections
- treatment
- mammals
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title abstract 3
- 241000124008 Mammalia Species 0.000 title abstract 2
- 201000008827 tuberculosis Diseases 0.000 abstract 2
- LZWMIKLBLVWHEY-UHFFFAOYSA-N 2-piperazin-1-yl-1,3-benzothiazin-4-one Chemical class S1C2=CC=CC=C2C(=O)N=C1N1CCNCC1 LZWMIKLBLVWHEY-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000006448 Buruli Ulcer Diseases 0.000 abstract 1
- 208000023081 Buruli ulcer disease Diseases 0.000 abstract 1
- 206010024229 Leprosy Diseases 0.000 abstract 1
- 206010066289 Mycobacterium ulcerans infection Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение относится к новым производным 2-пиперазин-1-ил-4H-1,3-бензотиазин-4-она и их применению для лечения инфекций у млекопитающих, вызванных бактериями, в частности таких заболеваний, как туберкулез (ТБ), язва Бурули и проказа, которые возникают в результате инфицирования близкородственными микобактериями.The present invention relates to new derivatives of 2-piperazin-1-yl-4H-1,3-benzothiazin-4-one and their use for the treatment of infections in mammals caused by bacteria, in particular diseases such as tuberculosis (TB), Buruli ulcer and leprosy, which result from infection with closely related mycobacteria.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010000688 | 2010-11-19 | ||
| PCT/IB2011/055209 WO2012066518A1 (en) | 2010-11-19 | 2011-11-21 | 2-piperazin-1-yl-4h-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201390639A1 true EA201390639A1 (en) | 2013-09-30 |
| EA023879B1 EA023879B1 (en) | 2016-07-29 |
Family
ID=45349249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201390639A EA023879B1 (en) | 2010-11-19 | 2011-11-21 | 2-piperazin-1-yl-4h-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8796264B2 (en) |
| EP (1) | EP2640712B1 (en) |
| JP (1) | JP6061346B2 (en) |
| KR (2) | KR101871970B1 (en) |
| CN (2) | CN103221399A (en) |
| AU (1) | AU2011330742B2 (en) |
| BR (1) | BR112013012280B1 (en) |
| CA (1) | CA2817931C (en) |
| EA (1) | EA023879B1 (en) |
| ES (1) | ES2690728T3 (en) |
| GE (1) | GEP201606545B (en) |
| HU (1) | HUE040152T2 (en) |
| IL (1) | IL226289A (en) |
| LT (1) | LT2640712T (en) |
| PL (1) | PL2640712T3 (en) |
| TR (1) | TR201815010T4 (en) |
| UA (1) | UA109557C2 (en) |
| WO (1) | WO2012066518A1 (en) |
| ZA (1) | ZA201303829B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103508980B (en) * | 2012-06-14 | 2016-07-06 | 四川大学 | Benzothiazine-4-ketone derivatives and its production and use |
| CN104211708B (en) * | 2013-05-29 | 2018-08-24 | 中国医学科学院药物研究所 | Benzoxazinone derivatives and its application as antiseptic |
| EP3096757B1 (en) | 2014-01-24 | 2020-10-21 | AI Therapeutics, Inc. | Apilimod compositions for treating non-hodgkin's b cell lymphoma |
| DE102014012546A1 (en) * | 2014-09-26 | 2016-03-31 | Martin-Luther-Universität Halle-Wittenberg | Antimycobacterially active substances, process for their preparation and their use |
| EP3215158B1 (en) | 2014-11-07 | 2019-05-08 | AI Therapeutics, Inc. | Apilimod for use in the treatment of renal cancer |
| EP3072889A1 (en) * | 2015-03-23 | 2016-09-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides |
| WO2018055048A1 (en) | 2016-09-22 | 2018-03-29 | Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie E.V. Hans-Knöll Institut (Hki) | New antimicrobial compounds, their use for the treatment of mammalian infections and a new metabolic mechanism |
| CN108929329B (en) * | 2017-05-24 | 2020-12-11 | 中国医学科学院药物研究所 | 2-Azacyclo-5-trifluoromethyl-8-nitrobenzo(thio)pyran-4-ones |
| RU2751163C9 (en) * | 2020-04-06 | 2021-10-20 | Общество С Ограниченной Ответственностью "Ниармедик Плюс" | Macozinone-based pharmaceutical composition for treatment of tuberculosis including multi- and extensively drug-resistant forms thereof |
| CN111303075A (en) * | 2020-04-08 | 2020-06-19 | 苏州大学 | Benzothiazinone derivatives and their preparation methods and their application as anti-tuberculosis drugs |
| KR102409518B1 (en) | 2020-06-22 | 2022-06-17 | 조은바이오주식회사 | By storing a large amount of river water to create an artificial fish farm and at the same time to reduce the generation of fine dust, it improves the polluted air in the atmosphere, and at the same time, preferentially discharges clean water molecules with a heavy specific gravity so that the polluted river water is converted into clean river water. A nature-friendly water purification eco-friendly method that naturally purifies the water quality of reservoirs, lakes, dams, lagoons, rivers, and rivers while producing a large amount of electricity using a nature-friendly eco-friendly water storage system configured to purify |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3470168A (en) | 1967-03-31 | 1969-09-30 | American Home Prod | 2-substituted-4h-1,3-benzothiazin-4-one derivatives |
| US3522247A (en) | 1967-11-07 | 1970-07-28 | Pfizer & Co C | 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators |
| PT2029583E (en) | 2006-05-24 | 2010-08-12 | Leibniz Inst Naturstoff Forsch | New benzothiazinone derivatives and their use as antibacterial agents |
| EP2020406A1 (en) | 2007-07-16 | 2009-02-04 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut | New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection |
| EP2380886A1 (en) * | 2010-04-23 | 2011-10-26 | Vadim A. Makarov | Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones |
| CN102367239B (en) * | 2011-07-20 | 2015-10-28 | 沈阳药科大学 | 2-aryl-2, 3-dihydro-4H-1, 3-benzothiazin-4-one derivatives and application thereof |
-
2011
- 2011-11-21 ES ES11796822.2T patent/ES2690728T3/en active Active
- 2011-11-21 CN CN2011800558135A patent/CN103221399A/en active Pending
- 2011-11-21 JP JP2013539392A patent/JP6061346B2/en active Active
- 2011-11-21 WO PCT/IB2011/055209 patent/WO2012066518A1/en active Application Filing
- 2011-11-21 EP EP11796822.2A patent/EP2640712B1/en active Active
- 2011-11-21 CA CA2817931A patent/CA2817931C/en active Active
- 2011-11-21 PL PL11796822T patent/PL2640712T3/en unknown
- 2011-11-21 LT LTEP11796822.2T patent/LT2640712T/en unknown
- 2011-11-21 HU HUE11796822A patent/HUE040152T2/en unknown
- 2011-11-21 BR BR112013012280-3A patent/BR112013012280B1/en not_active IP Right Cessation
- 2011-11-21 AU AU2011330742A patent/AU2011330742B2/en active Active
- 2011-11-21 UA UAA201307177A patent/UA109557C2/en unknown
- 2011-11-21 KR KR1020137015671A patent/KR101871970B1/en not_active Expired - Fee Related
- 2011-11-21 TR TR2018/15010T patent/TR201815010T4/en unknown
- 2011-11-21 KR KR1020177034344A patent/KR101851774B1/en not_active Expired - Fee Related
- 2011-11-21 CN CN201710192245.2A patent/CN107011287A/en active Pending
- 2011-11-21 EA EA201390639A patent/EA023879B1/en not_active IP Right Cessation
- 2011-11-21 US US13/884,825 patent/US8796264B2/en active Active
- 2011-11-21 GE GEAP201113122A patent/GEP201606545B/en unknown
-
2013
- 2013-05-09 IL IL226289A patent/IL226289A/en active IP Right Grant
- 2013-05-27 ZA ZA2013/03829A patent/ZA201303829B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103221399A (en) | 2013-07-24 |
| AU2011330742B2 (en) | 2016-10-13 |
| KR20170137211A (en) | 2017-12-12 |
| PL2640712T3 (en) | 2019-03-29 |
| IL226289A0 (en) | 2013-07-31 |
| EP2640712A1 (en) | 2013-09-25 |
| UA109557C2 (en) | 2015-09-10 |
| JP6061346B2 (en) | 2017-01-18 |
| GEP201606545B (en) | 2016-09-26 |
| WO2012066518A1 (en) | 2012-05-24 |
| KR101851774B1 (en) | 2018-04-25 |
| IL226289A (en) | 2016-07-31 |
| CA2817931C (en) | 2017-10-31 |
| LT2640712T (en) | 2018-11-12 |
| KR20140012956A (en) | 2014-02-04 |
| KR101871970B1 (en) | 2018-08-02 |
| BR112013012280A2 (en) | 2020-09-01 |
| CN107011287A (en) | 2017-08-04 |
| CA2817931A1 (en) | 2012-05-24 |
| EA023879B1 (en) | 2016-07-29 |
| US8796264B2 (en) | 2014-08-05 |
| AU2011330742A1 (en) | 2013-06-27 |
| HUE040152T2 (en) | 2019-02-28 |
| ES2690728T3 (en) | 2018-11-22 |
| TR201815010T4 (en) | 2018-11-21 |
| JP2013542980A (en) | 2013-11-28 |
| US20130245007A1 (en) | 2013-09-19 |
| EP2640712B1 (en) | 2018-07-11 |
| BR112013012280B1 (en) | 2022-01-04 |
| ZA201303829B (en) | 2014-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ TJ TM |