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EA200200016A1 - Способ получения чистого циталопрама - Google Patents

Способ получения чистого циталопрама

Info

Publication number
EA200200016A1
EA200200016A1 EA200200016A EA200200016A EA200200016A1 EA 200200016 A1 EA200200016 A1 EA 200200016A1 EA 200200016 A EA200200016 A EA 200200016A EA 200200016 A EA200200016 A EA 200200016A EA 200200016 A1 EA200200016 A1 EA 200200016A1
Authority
EA
Eurasian Patent Office
Prior art keywords
citalopram
cyanide
subjected
formula
cytaloprama
Prior art date
Application number
EA200200016A
Other languages
English (en)
Other versions
EA003459B1 (ru
Inventor
Андреа Кастеллин
Джулио Вольпе
Федерико Сброджо
Original Assignee
Х.Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х.Лундбекк А/С filed Critical Х.Лундбекк А/С
Publication of EA200200016A1 publication Critical patent/EA200200016A1/ru
Publication of EA003459B1 publication Critical patent/EA003459B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Описывается способ получения циталопрама формулы (I), по которому соединение формулы (II), в которой Z означает иод, бром, хлор или CF-(CF)-SO-O-, n равно 0, 1, 2, 3, 4, 5, 6, 7 или 8, подвергают реакции цианидного обмена, по которой группа Z обменивается с цианидной группой по реакции с цианидным источником; полученный сырой продукт - циталопрам, необязательно, подвергают некоторой первоначальной очистке и сырое основание циталопрама впоследствии подвергают процессу пленочной дистилляции; полученный продукт - циталопрам затем, необязательно, дополнительно очищают и обрабатывают и выделяют в виде основания или его фармацевтически приемлемой соли.Отчет о международном поиске был опубликован 2001.12.27.
EA200200016A 2000-12-28 2001-03-07 Способ получения чистого циталопрама EA003459B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001943 2000-12-28
PCT/DK2001/000148 WO2001047877A2 (en) 2000-12-28 2001-03-07 Process for the preparation of pure citalopram

Publications (2)

Publication Number Publication Date
EA200200016A1 true EA200200016A1 (ru) 2002-04-25
EA003459B1 EA003459B1 (ru) 2003-06-26

Family

ID=8159933

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200016A EA003459B1 (ru) 2000-12-28 2001-03-07 Способ получения чистого циталопрама

Country Status (41)

Country Link
US (2) US6855834B2 (ru)
EP (1) EP1181272B1 (ru)
JP (1) JP2003519121A (ru)
KR (1) KR100430746B1 (ru)
CN (1) CN1366526A (ru)
AR (1) AR029898A1 (ru)
AT (2) ATE222899T1 (ru)
AU (3) AU2001100399B4 (ru)
BE (2) BE1013417A6 (ru)
BG (1) BG106219A (ru)
BR (1) BR0106271A (ru)
CA (1) CA2359810C (ru)
CH (1) CH691536A5 (ru)
CZ (1) CZ293140B6 (ru)
DE (1) DE60100016T2 (ru)
DK (1) DK1181272T3 (ru)
EA (1) EA003459B1 (ru)
ES (2) ES2181663T3 (ru)
FI (2) FI108640B (ru)
FR (1) FR2818977B1 (ru)
GB (2) GB2356199B (ru)
GR (1) GR20010100131A (ru)
HK (1) HK1049332A1 (ru)
HR (1) HRP20020005A2 (ru)
HU (2) HU0101028D0 (ru)
IE (2) IES20010253A2 (ru)
IL (1) IL147162A0 (ru)
IS (1) IS5884A (ru)
IT (1) ITMI20010604A1 (ru)
MX (1) MXPA01013336A (ru)
NL (1) NL1017534C1 (ru)
NO (1) NO313047B1 (ru)
NZ (1) NZ516299A (ru)
PL (1) PL353369A1 (ru)
PT (1) PT1181272E (ru)
SE (1) SE0103044L (ru)
SK (1) SK284418B6 (ru)
TR (1) TR200200018T1 (ru)
UA (1) UA71635C2 (ru)
WO (1) WO2001047877A2 (ru)
ZA (1) ZA200110133B (ru)

Families Citing this family (31)

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AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
JP3798940B2 (ja) * 1999-04-14 2006-07-19 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
SI1298124T1 (sl) 1999-10-25 2007-08-31 Lundbeck & Co As H Postopek za pripravo citaloprama
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
HK1052512B (zh) 1999-12-30 2006-03-03 H. 隆德贝克有限公司 西酞普兰的制备方法
CZ20022601A3 (cs) 2000-01-14 2002-10-16 H. Lundbeck A/S Způsob výroby 5-kyanoftalidu
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
BR0109176A (pt) 2000-03-13 2003-04-22 Lundbeck & Co As H Método para preparação de citalopram e composto da fórmula
HUP0300273A2 (hu) * 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás 5-szubsztituált 1-(4-fluorfenil)-1,3-dihidroizobenzofurán-származékok lépésenkénti alkilezésére
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PL360107A1 (en) 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
HUP0300134A2 (en) * 2000-03-16 2003-05-28 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A7 (fi) 2000-08-18 2002-02-19 H Lundbeck As Menetelmä sitalopraamin valmistamiseksi
SK284428B6 (sk) 2000-12-22 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu
HK1049332A1 (zh) 2000-12-28 2003-05-09 H‧隆德贝克有限公司 純西酞普蘭的製備方法
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
US7148364B2 (en) 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

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US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
JP2003519121A (ja) 2003-06-17
IS5884A (is) 2002-06-28
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
AU3920201A (en) 2001-07-09
CA2359810A1 (en) 2001-07-05
AU2001100399A4 (en) 2001-11-01
FR2818977B1 (fr) 2003-12-05
WO2001047877A2 (en) 2001-07-05
NZ516299A (en) 2002-12-20
EA003459B1 (ru) 2003-06-26
SE0103044D0 (sv) 2001-09-14
IL147162A0 (en) 2002-08-14
GB2361697A (en) 2001-10-31
DE60100016T2 (de) 2003-04-17
HK1049332A1 (zh) 2003-05-09
CA2359810C (en) 2002-11-05
HU0101028D0 (en) 2001-05-28
PT1181272E (pt) 2003-01-31
BG106219A (en) 2002-08-30
ZA200110133B (en) 2003-01-13
HU0102818D0 (en) 2001-09-28
UA71635C2 (ru) 2004-12-15
CN1366526A (zh) 2002-08-28
SE0103044L (sv) 2002-06-29
CZ2001891A3 (cs) 2002-08-14
CH691536A5 (de) 2001-08-15
AU2001100399B4 (en) 2002-03-21
SK284418B6 (sk) 2005-04-01
WO2001047877A3 (en) 2001-12-27
BE1013417A6 (fr) 2001-12-04
FR2818977A1 (fr) 2002-07-05
EP1181272B1 (en) 2002-08-28
ATE222899T1 (de) 2002-09-15
AT4368U1 (de) 2001-06-25
DK1181272T3 (da) 2002-12-30
BE1013316A6 (fr) 2001-11-06
US6855834B2 (en) 2005-02-15
NL1017534C1 (nl) 2001-04-26
GB0105981D0 (en) 2001-05-02
US20030178295A1 (en) 2003-09-25
HUP0102818A3 (en) 2003-07-28
EP1181272A2 (en) 2002-02-27
US20020087012A1 (en) 2002-07-04
KR100430746B1 (ko) 2004-05-10
NO20011272D0 (no) 2001-03-13
AU750006B1 (en) 2002-07-11
KR20020073379A (ko) 2002-09-26
ES2170733A1 (es) 2002-08-01
FI20011578A0 (fi) 2001-07-26
FI108640B (fi) 2002-02-28
ES2170733B1 (es) 2003-12-16
GB0117095D0 (en) 2001-09-05
PL353369A1 (en) 2003-11-17
MXPA01013336A (es) 2002-07-09
GR20010100131A (el) 2002-10-09
IES20010253A2 (en) 2002-03-06
AR029898A1 (es) 2003-07-23
HUP0102818A2 (hu) 2001-12-28
HRP20020005A2 (en) 2003-04-30
ITMI20010604A1 (it) 2002-09-22
ITMI20010604A0 (it) 2001-03-22
BR0106271A (pt) 2002-05-21
CZ293140B6 (cs) 2004-02-18
NO20011272L (no) 2002-07-01
ES2181663T3 (es) 2003-03-01
SK18472001A3 (sk) 2002-05-09
GB2356199B (en) 2001-10-03
DE60100016D1 (de) 2002-10-02
NO313047B1 (no) 2002-08-05
TR200200018T1 (tr) 2002-06-21
IES20010632A2 (en) 2002-03-06

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