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DK2419447T3 - Antistoffer, der specifikt binder til a beta-oligomerer og anvendelse deraf - Google Patents

Antistoffer, der specifikt binder til a beta-oligomerer og anvendelse deraf Download PDF

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Publication number
DK2419447T3
DK2419447T3 DK10764291.0T DK10764291T DK2419447T3 DK 2419447 T3 DK2419447 T3 DK 2419447T3 DK 10764291 T DK10764291 T DK 10764291T DK 2419447 T3 DK2419447 T3 DK 2419447T3
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antibody
seq
amino acid
acid sequence
chain
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DK10764291.0T
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English (en)
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Tatsuki Yokoseki
Yasuhide Okamoto
Makoto Umeda
Toshiyuki Ito
Yukiho Imai
Shinobu Fujii
Naofumi Takamatsu
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Immunas Pharma Inc
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Publication of DK2419447T3 publication Critical patent/DK2419447T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (10)

1. Antistof, der genkender en isoleret A beta-tetramer som et antigen, hvor antistoffet ikke binder til en A beta-monomer, der er valgt fra gruppen bestående af: - et antistof, der omfatter en H-kæde med aminosyresekvensen af SEQ ID NO: 262 som CDR1, aminosyresekvensen af SEQ ID NO: 264 som CDR2, og aminosyresekvensen af SEQ ID NO: 266 som CDR3, og en L-kæde med aminosyresekvensen af SEQ ID NO: 268 som CDR1, aminosyresekvensen af SEQ ID NO: 270 som CDR2, og aminosyresekvensen af SEQ ID NO: 272 som CDR3; og - et antistof, der omfatter en H-kæde med aminosyresekvensen af SEQ ID NO: 594 som VH og en L-kæde med aminosyresekvensen af SEQ ID NO: 596 som VL.
2. Antistoffet ifølge krav 1, hvor antistoffet er et kimært antistof eller et humaniseret antistof.
3. Antigen-bindende fragment af antistoffet ifølge krav 1 eller 2, hvor det antigenbindende fragment er valgt fra Fab, Fab', F(ab')2, Fv, scFv, diabody og sc(Fv)2.
4. Farmaceutisk sammensætning omfattende antistoffet ifølge krav 1 eller 2 eller det antigen-bindende fragment ifølge krav 3, og en farmaceutisk acceptabel bærer.
5. Sammensætningen ifølge krav 4, hvilken omfatter et middel mod kognitiv svækkelse, et terapeutisk middel mod Alzheimers sygdom, et middel til at undertrykke udviklingen af Alzheimers sygdom, et middel til at undertrykke senil plaquedannelse, et middel til at hæmme A beta-akkumulation, et anti- neurotoksisk middel, et middel til at inhibere A beta-amyloid-fibrildannelse eller et middel mod synaptisk toksicitet.
6. Fremgangsmåde til at detektere en A beta-oligomer, hvilken omfatter trinnet at detektere en A beta-oligomer indeholdt i en prøve under anvendelse af antistoffet ifølge krav 1 eller 2 eller det antigen-bindende fragment ifølge krav 3.
7. Fremgangsmåde til at diagnosticere hvorvidt et individ er en eventuel patient med Alzheimers sygdom eller ej, hvilken omfatter at anvende antistoffet ifølge krav 1 eller 2 eller det antigen-bindende fragment ifølge krav 3 til at detektere en A beta-oligomer i en prøve indsamlet fra et individ.
8. Fremgangsmåden ifølge krav 7, hvilken omfatter trinnene: (a) at bringe en prøve indsamlet fra et individ i kontakt med antistoffet ifølge krav 1 eller 2 eller det antigen-bindende fragment ifølge krav 3; og (b) at måle mængden af A beta-oligomer i prøven, hvor individet bestemmes til at være en eventuel patient med Alzheimers sygdom, når mængden målt i trin (b) er højere end den af et sundt individ.
9. Fremgangsmåden ifølge et hvilket som helst af kravene 6 til 8, hvor prøven er blod eller cerebrospinalvæske.
10. Kit til at detektere A beta-oligomerer eller til at diagnosticere Alzheimers sygdom, omfattende antistoffet ifølge krav 1 eller 2 eller det antigen-bindende fragment ifølge krav 3.
DK10764291.0T 2009-04-17 2010-04-16 Antistoffer, der specifikt binder til a beta-oligomerer og anvendelse deraf DK2419447T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21298609P 2009-04-17 2009-04-17
US28254910P 2010-02-26 2010-02-26
PCT/JP2010/002771 WO2010119704A1 (en) 2009-04-17 2010-04-16 Antibodies that specifically bind to a beta oligomers and use thereof

Publications (1)

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DK2419447T3 true DK2419447T3 (da) 2017-09-25

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US (1) US9090679B2 (da)
EP (1) EP2419447B1 (da)
JP (1) JP5812418B2 (da)
CN (1) CN102459335B (da)
DK (1) DK2419447T3 (da)
ES (1) ES2641612T3 (da)
WO (1) WO2010119704A1 (da)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3053179B2 (ja) 1998-09-18 2000-06-19 不動建設株式会社 浚渫等の土砂の固化移送処理方法
LT2436696T (lt) * 2007-01-05 2017-08-25 University Of Zurich Anti-beta-amiloido antikūnas ir jo panaudojimas
HRP20140049T1 (hr) 2007-01-05 2014-02-28 University Of Zürich Anti beta-amiloid antitijela i njihova upotreba
WO2009051220A1 (ja) * 2007-10-19 2009-04-23 Immunas Pharma, Inc. Aβオリゴマーに特異的に結合する抗体およびその利用
JP5113853B2 (ja) 2008-02-08 2013-01-09 イムナス・ファーマ株式会社 Ａβオリゴマーに特異的に結合する抗体およびその利用
CA2730073A1 (en) * 2008-07-09 2010-01-14 University Of Zurich Method of promoting neurogenesis
US9085614B2 (en) 2008-08-01 2015-07-21 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
DK2949666T3 (da) 2008-12-19 2019-03-25 Biogen Int Neuroscience Gmbh Humane anti-alpha-synuclein-antistoffer
WO2011016238A1 (en) 2009-08-06 2011-02-10 Immunas Pharma, Inc. Antibodies that specifically bind to a beta oligomers and use thereof
US8613924B2 (en) 2009-08-06 2013-12-24 Immunas Pharma, Inc. Antibodies that specifically bind to A beta oligomers and use thereof
CA2818237C (en) 2009-11-18 2021-05-18 University Of Medicine And Dentistry Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
US9849192B2 (en) 2009-11-18 2017-12-26 Rutgers, The State University Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
DK2544719T3 (da) * 2010-03-12 2019-10-14 Debiopharm Int Sa Cd37-bindingsmolekyler og immunkonjugater deraf
EP2576617B1 (en) * 2010-06-04 2016-04-27 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin MONOCLONAL ANTIBODIES TARGETING Aß OLIGOMERS
MX357193B (es) 2011-06-23 2018-06-29 Univ Zuerich Moleculas de union anti-alfa sinucleina.
CA2871116A1 (en) * 2012-05-14 2013-11-21 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP2869837B1 (en) 2012-07-04 2016-09-14 F. Hoffmann-La Roche AG Anti-theophylline antibodies and methods of use
KR102090849B1 (ko) 2012-07-04 2020-03-19 에프. 호프만-라 로슈 아게 공유 결합된 항원-항체 접합체
KR20150030755A (ko) 2012-07-04 2015-03-20 에프. 호프만-라 로슈 아게 항-바이오틴 항체 및 사용 방법
EP3838923B1 (en) 2012-08-24 2024-05-01 The Regents of The University of California Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
US9549993B2 (en) 2012-10-02 2017-01-24 Rutgers, The State University Of New Jersey Specific delivery of toxins conjugated with antibodies to activate matripase
WO2015054427A1 (en) 2013-10-10 2015-04-16 Beth Israel Deaconess Medical Center, Inc. Tm4sf1 binding proteins and methods of using same
US10494434B2 (en) 2013-12-20 2019-12-03 Fred Hutchinson Cancer Research Center Tagged chimeric effector molecules and receptors thereof
MX373017B (es) 2014-01-03 2020-04-28 Hoffmann La Roche Conjugados de toxina polipeptidica-anticuerpo unidos covalentemente.
WO2015101587A1 (en) 2014-01-03 2015-07-09 F. Hoffmann-La Roche Ag Covalently linked helicar-anti-helicar antibody conjugates and uses thereof
JP6476194B2 (ja) 2014-01-03 2019-02-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重特異性抗ハプテン／抗血液脳関門受容体抗体、それらの複合体、及び血液脳関門シャトルとしてのそれらの使用
EP4159761A1 (en) 2014-03-27 2023-04-05 Bird Rock Bio, Inc. Antibodies that bind human cannabinoid 1 (cb1) receptor
KR102092225B1 (ko) * 2014-04-30 2020-03-23 주식회사 엘지화학 고효율 분비능을 가지는 단백질 분비 인자 및 이를 포함하는 발현 벡터
SG11201700787XA (en) 2014-08-07 2017-02-27 Sloan Kettering Inst Cancer Anti-ceramide antibodies
DK3201234T3 (da) 2014-09-30 2019-02-25 Diadem S R L Antistof der binder en lineær epitop af human p53 og diagnostiske anvendelser deraf
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
AU2016210835B2 (en) * 2015-01-29 2021-01-21 Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders
WO2016149116A1 (en) * 2015-03-13 2016-09-22 University Of Maryland, Baltimore Antibodies targeting s100b and methods of use
US11827904B2 (en) 2015-04-29 2023-11-28 Fred Hutchinson Cancer Center Modified stem cells and uses thereof
EP3708585A1 (en) 2015-05-04 2020-09-16 CytomX Therapeutics, Inc. Anti-cd166 antibodies, activatable anti-cd166 antibodies, and methods of use thereof
CN108883163B (zh) 2015-09-04 2022-04-15 健康研究公司 用于癌症治疗的抗存活蛋白抗体
WO2017056905A1 (ja) 2015-09-29 2017-04-06 浜松ホトニクス株式会社 アミロイドβオリゴマーの検出方法、アミロイドβオリゴマー検出装置及びアミロイドβオリゴマー検出プログラム
MX2018003982A (es) 2015-09-30 2019-01-31 Bird Rock Bio Inc Anticuerpos que se unen al receptor cannabinoide 1 (cb1) humano.
KR20180094876A (ko) 2015-11-09 2018-08-24 더 유니버시티 오브 브리티쉬 콜롬비아 아밀로이드 베타 에피토프 및 이에 대한 항체
EP3374381A4 (en) 2015-11-09 2019-05-15 The University Of British Columbia EPITOPES IN THE AMYLOID-BETA MEDIUM REGION AND CONFORMITY-SELECTIVE ANTIBODIES THEREOF
CN108350051A (zh) 2015-11-09 2018-07-31 英属哥伦比亚大学 淀粉样蛋白β中的N-末端表位及其构象选择性抗体
CN106810609A (zh) * 2015-11-27 2017-06-09 苏州君盟生物医药科技有限公司 抗pcsk9抗体及其应用
WO2017148424A1 (zh) * 2016-03-04 2017-09-08 四川科伦博泰生物医药股份有限公司 一种pdl-1抗体、其药物组合物及其用途
IL261188B (en) 2016-03-04 2022-08-01 Jn Biosciences Llc Anti-tigit antibody that binds to a tigit polypeptide on one or more amino acid residues
CN105732814B (zh) * 2016-03-08 2019-05-28 苏州大学 抗人血管性血友病因子a3区的人鼠嵌合单克隆抗体及其制备方法和应用
WO2017161288A1 (en) 2016-03-18 2017-09-21 Rutgers, The State University Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to anti-matriptase antibodies by in vivo cleavable linking moieties
EP3436480A4 (en) * 2016-03-30 2019-11-27 Musc Foundation for Research Development METHOD FOR THE TREATMENT AND DIAGNOSIS OF CANCER BY TARGETING GLYCOPROTEIN A REPETITION PREDOMINANT (GARP) AND FOR EFFECTIVE IMMUNOTHERAPY ALONE OR IN COMBINATION
WO2017192483A1 (en) * 2016-05-05 2017-11-09 Mapp Biopharmaceutical, Inc. Monoclonal antibody cocktail for treatment of ebola infections
WO2018005519A2 (en) 2016-06-27 2018-01-04 The Regents Of The University Of California Cancer treatment combinations
EP3484919A4 (en) * 2016-07-18 2020-03-04 The University of British Columbia ANTI-BETA-AMYLOID ANTIBODIES
US20180125920A1 (en) 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
WO2018152452A1 (en) 2017-02-17 2018-08-23 Mapp Biopharmaceutical, Inc. Monoclonal antibodies and cocktails for treatment of ebola infections
SG11201908238SA (en) * 2017-03-06 2019-10-30 The Trustees Of The Univ Of Pensylvania Anti-c5 antibodies and uses thereof
US11220544B2 (en) * 2017-07-14 2022-01-11 Cytomx Therapeutics, Inc. Anti-CD166 antibodies and uses thereof
US12286469B2 (en) 2017-07-18 2025-04-29 The University Of British Columbia Humanized antibodies binding to amyloid-beta (A-beta)
IL272773B2 (en) 2017-08-22 2024-06-01 Biogen Ma Inc Pharmaceutical compositions containing anti-beta amyloid antibodies
US20200262894A1 (en) * 2017-09-06 2020-08-20 Fred Hutchinson Cancer Research Center Strep-tag specific binding proteins and uses thereof
CN113226367B (zh) 2018-04-06 2025-05-06 Atyr医药公司 包括抗nrp2抗体的组合物和方法
MY203453A (en) * 2018-07-17 2024-06-28 Shanghai hengrui pharmaceutical co ltd Anti-abeta antibody, antigen-binding fragment thereof and application thereof
SG11202101853PA (en) 2018-09-06 2021-03-30 Univ Pennsylvania Humanized anti-c5 antibodies and uses thereof
CN109725159B (zh) * 2018-12-28 2021-10-08 江苏众红生物工程创药研究院有限公司 人β2-微球蛋白的定量检测试纸卡与临床应用
CN113508141B (zh) * 2019-02-01 2024-10-29 住友化学株式会社 抗体及其功能片段
EP3757125A1 (en) * 2019-06-28 2020-12-30 BioArctic AB Antibody directed against the apoe amino-terminal fragment of 12 kda
US20220332805A1 (en) * 2019-09-11 2022-10-20 University Of Cincinnati Treatment of Skin Blistering Diseases Using Antibodies
WO2021056025A2 (en) * 2019-09-20 2021-03-25 Board Of Regents, The University Of Texas System Anti-epha10 antibodies and methods of use thereof
WO2021055670A1 (en) 2019-09-20 2021-03-25 Avx Corporation Somatic cell-based electrical biosensor
US11807687B2 (en) 2019-10-03 2023-11-07 Atyr Pharma, Inc. Therapeutic compositions comprising anti-NRP2 antibodies
CA3171531A1 (en) * 2020-03-18 2021-09-23 Daniel Wreschner Anti- muc1-sea antibodies
US20230192824A1 (en) * 2020-04-02 2023-06-22 United States Of America As Represented By The Secretary Of The Navy Antigen Binding Proteins to Class 5 ETEC Adhesins
BR112022023892A2 (pt) * 2020-05-29 2022-12-27 Verseau Therapeutics Inc Composições anti-vsig4 e métodos para modular fenótipos inflamatórios de células mieloides e seus usos
CR20220611A (es) 2020-06-02 2023-06-07 Arcus Biosciences Inc Anticuerpos anti-tigit
CN113842456B (zh) * 2020-06-28 2022-07-26 上海齐鲁制药研究中心有限公司 一种抗人4-1bb的单克隆抗体制剂及其用途
CN112225811A (zh) * 2020-07-16 2021-01-15 上海恒润达生生物科技有限公司 新型抗人msln抗体及其用途
CN116348487A (zh) 2020-07-23 2023-06-27 欧萨尔普罗席纳有限公司 抗淀粉样β抗体
CN112062852B (zh) * 2020-07-28 2021-10-12 浙江大学 一种抗噻虫胺和呋虫胺宽谱抗体的可变区序列及其重组完整抗体的制备
CN113151186B (zh) * 2021-02-04 2022-02-18 上海交通大学 抗人cd271的单克隆抗体及用途
CN115197323A (zh) * 2021-04-08 2022-10-18 上海复旦张江生物医药股份有限公司 一种sn38抗体或其抗原结合片段及其应用
WO2022268196A1 (zh) * 2021-06-25 2022-12-29 天辰生物医药(苏州)有限公司 靶向gpc3的抗原结合蛋白
WO2023076998A1 (en) * 2021-10-27 2023-05-04 Atyr Pharma, Inc. COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2a ANTIBODIES
CN114478783B (zh) * 2022-01-07 2022-11-29 陕西脉元生物科技有限公司 一种eno2单克隆抗体及其制备方法和应用
CN114594272B (zh) * 2022-05-07 2022-08-23 北京第一生物化学药业有限公司 用于检测β-淀粉样蛋白的产品和方法
TW202413437A (zh) * 2022-08-05 2024-04-01 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合ｇｕｃｙ２ｃ和ｃｄ３的抗原結合分子及其醫藥用途
CN118255881B (zh) * 2022-12-26 2025-08-12 菲鹏生物股份有限公司 D-二聚体抗体及其用途
CN119306826B (zh) * 2023-07-11 2025-06-20 东莞市朋志生物科技有限公司 抗白介素-6抗体、检测白介素-6的试剂和试剂盒
CN119490596A (zh) * 2023-08-21 2025-02-21 菲鹏生物股份有限公司 一种抗人IgM抗体及其应用
WO2025044931A1 (zh) * 2023-08-25 2025-03-06 康诺亚生物医药科技（成都）有限公司 阿尔茨海默病治疗剂的开发和应用
CN118271437B (zh) * 2024-05-31 2024-08-13 江西赛基生物技术有限公司 一种抗Tau蛋白单克隆抗体及其制备方法和应用
CN119841947A (zh) * 2024-12-17 2025-04-18 河南农业大学 十二指肠贾第虫cwp2蛋白的单克隆抗体及配对单克隆抗体及应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0239102A3 (en) 1986-03-28 1989-07-12 Tsuji, Kimiyoshi Process for the formation of human-human hybridoma
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
AU675661B2 (en) 1992-07-24 1997-02-13 Abgenix, Inc. Generation of xenogeneic antibodies
JPH08509612A (ja) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
ATE390933T1 (de) 1995-04-27 2008-04-15 Amgen Fremont Inc Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6218506B1 (en) 1997-02-05 2001-04-17 Northwestern University Amyloid β protein (globular assembly and uses thereof)
US20030068316A1 (en) 1997-02-05 2003-04-10 Klein William L. Anti-ADDL antibodies and uses thereof
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
AUPR617901A0 (en) 2001-07-06 2001-08-02 Pacmab Pty Ltd Method for treating multiple myeloma
DE60226036T9 (de) 2001-08-03 2016-09-29 Medical & Biological Laboratories Co., Ltd. ANTIKÖRPER, DER DAS GM1-GANGLIOSID-GEBUNDENE AMYLOID-b-PROTEIN ERKENNT, UND DNA, DIE FÜR DIESEN ANTIKÖRPER CODIERT
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
WO2010012004A2 (en) * 2008-07-25 2010-01-28 The Regents Of The University Of California Monoclonal antibodies specific for pathological amyoid aggregates common to amyloids formed from proteins of differing sequence
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US8394379B2 (en) 2003-05-15 2013-03-12 Iogenetics, Llc Targeted cryptosporidium biocides
US8507206B2 (en) 2004-07-02 2013-08-13 Northwestern University Monoclonal antibodies that target pathological assemblies of amyloid β (Abeta)
US20080044356A1 (en) 2004-10-22 2008-02-21 Regents Of The University Of Minnesota Assemblies of Oligomeric Amyloid Beta Protein and Uses Thereof
KR20070094890A (ko) 2004-10-25 2007-09-27 머크 앤드 캄파니 인코포레이티드 안티 ａｄｄｌ 항체 및 그 용도
CA2790433A1 (en) 2004-10-25 2006-05-26 Northwestern University Anti-addl antibodies and uses thereof
PE20061401A1 (es) 2004-12-15 2006-12-23 Neuralab Ltd ANTICUERPOS Aß PARA MEJORAR LA COGNICION
US20110020237A1 (en) * 2005-01-14 2011-01-27 Glabe Charles G Compositions and Methods for Inhibiting Drusen Formation and for Diagnosing or Treating Drusen-Related Disorders
AU2006208226A1 (en) 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
US7731962B2 (en) 2005-02-14 2010-06-08 Merck & Co., Inc. Anti-ADDL monoclonal antibody and use thereof
AU2006222193B2 (en) 2005-03-05 2011-11-17 AbbVie Deutschland GmbH & Co. KG Screening method, process for purifying of non-diffusible A-beta oligomers, selective antibodies against said non-diffusible A-beta oligomers and a process for manufacturing of said antibodies
WO2006137354A1 (ja) 2005-06-21 2006-12-28 Medical & Biological Laboratories Co., Ltd. アミロイド線維形成に対する阻害活性を有する抗体
EP1749839A1 (en) 2005-07-22 2007-02-07 Novoplant GmbH Antigen binding polypeptides against F4(K88) fimbriae
JP5033868B2 (ja) 2006-03-23 2012-09-26 バイオアークティック ニューロサイエンス アーベー 改良型プロトフィブリル選択的抗体及びその使用
US20090232801A1 (en) * 2007-05-30 2009-09-17 Abbot Laboratories Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof
US20100291071A1 (en) 2008-08-01 2010-11-18 Immunas Pharma, Inc. Antibody Specific Binding to A-Beta Oligomer and the Use
WO2009051220A1 (ja) 2007-10-19 2009-04-23 Immunas Pharma, Inc. Aβオリゴマーに特異的に結合する抗体およびその利用
US8414893B2 (en) * 2007-12-21 2013-04-09 Amgen Inc. Anti-amyloid antibodies and uses thereof
JP5113853B2 (ja) 2008-02-08 2013-01-09 イムナス・ファーマ株式会社 Ａβオリゴマーに特異的に結合する抗体およびその利用
NZ589436A (en) * 2008-06-03 2012-12-21 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US9085614B2 (en) 2008-08-01 2015-07-21 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
WO2011016238A1 (en) 2009-08-06 2011-02-10 Immunas Pharma, Inc. Antibodies that specifically bind to a beta oligomers and use thereof
US8613924B2 (en) 2009-08-06 2013-12-24 Immunas Pharma, Inc. Antibodies that specifically bind to A beta oligomers and use thereof

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US20120082667A1 (en) 2012-04-05
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