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DK1712920T3 - Tidlig diagnose af konformationelle sygdomme - Google Patents

Tidlig diagnose af konformationelle sygdomme

Info

Publication number
DK1712920T3
DK1712920T3 DK06015975T DK06015975T DK1712920T3 DK 1712920 T3 DK1712920 T3 DK 1712920T3 DK 06015975 T DK06015975 T DK 06015975T DK 06015975 T DK06015975 T DK 06015975T DK 1712920 T3 DK1712920 T3 DK 1712920T3
Authority
DK
Denmark
Prior art keywords
early diagnosis
conformational diseases
conformational
diseases
diagnosis
Prior art date
Application number
DK06015975T
Other languages
Danish (da)
English (en)
Inventor
Claudio Soto-Jaro
Gabriela Saborio
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Application granted granted Critical
Publication of DK1712920T3 publication Critical patent/DK1712920T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK06015975T 2000-07-07 2001-06-13 Tidlig diagnose af konformationelle sygdomme DK1712920T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
PCT/GB2001/002584 WO2002004954A2 (fr) 2000-07-07 2001-06-13 Diagnostic precoce de maladies conformationelles

Publications (1)

Publication Number Publication Date
DK1712920T3 true DK1712920T3 (da) 2009-05-11

Family

ID=27223071

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01938411T DK1299729T3 (da) 2000-07-07 2001-06-13 Tidlig diagnosticering af konformationelle sygdomme
DK06015975T DK1712920T3 (da) 2000-07-07 2001-06-13 Tidlig diagnose af konformationelle sygdomme

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK01938411T DK1299729T3 (da) 2000-07-07 2001-06-13 Tidlig diagnosticering af konformationelle sygdomme

Country Status (30)

Country Link
US (1) US7351526B2 (fr)
EP (2) EP1299729B1 (fr)
JP (1) JP4790966B2 (fr)
KR (1) KR100764981B1 (fr)
CN (1) CN1221807C (fr)
AR (1) AR029583A1 (fr)
AT (2) ATE426816T1 (fr)
AU (2) AU2001264089B2 (fr)
BG (1) BG66272B1 (fr)
BR (1) BRPI0112262B8 (fr)
CA (1) CA2413078C (fr)
CY (1) CY1109106T1 (fr)
CZ (1) CZ304365B6 (fr)
DE (2) DE60121958T2 (fr)
DK (2) DK1299729T3 (fr)
EA (1) EA007391B1 (fr)
EE (1) EE05675B1 (fr)
ES (2) ES2322660T3 (fr)
HR (1) HRP20030033B1 (fr)
HU (1) HU228813B1 (fr)
IL (2) IL153824A0 (fr)
MX (1) MXPA03000226A (fr)
NO (1) NO331624B1 (fr)
NZ (1) NZ523213A (fr)
PL (1) PL211154B1 (fr)
PT (2) PT1712920E (fr)
RS (1) RS51523B (fr)
SI (2) SI1299729T1 (fr)
SK (1) SK287768B6 (fr)
WO (1) WO2002004954A2 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1373904A1 (fr) * 2001-03-13 2004-01-02 Eigen, Manfred, Prof. Dr. Procede permettant de renforcer la formation d'agregats de sous-unites proteiques
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
MXPA03011000A (es) 2001-05-31 2004-02-27 Arete Associates Metodo de sensor de proteinas deformadas.
CA2525517C (fr) 2003-06-19 2016-05-31 Applied Research Systems Ars Holding N.V. Utilisation d'agents modulateurs de la conversion de prions
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
US20070054322A1 (en) * 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
CA2535261C (fr) 2003-08-13 2015-11-24 Chiron Corporation Reactifs peptidiques specifiques du prion
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
EP1853915B1 (fr) * 2005-02-15 2011-10-12 Adlyfe, Inc. Procede de detection de proteines et de prions a repliement incorrect
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
EP1731911A1 (fr) 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
US7834144B2 (en) 2005-09-09 2010-11-16 Novartis Ag Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
US8673579B2 (en) 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
EP2074222A4 (fr) * 2006-09-06 2010-03-03 Univ Texas Méthodes et compositions pour la détection de troubles du repliement des protéines
WO2009015091A1 (fr) * 2007-07-20 2009-01-29 The Government of the United States of America as represented by the Secretary of the Détection de protéine prion infectieuse par conversion à germes de protéine prion recombinante
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
JP5209712B2 (ja) 2008-05-28 2013-06-12 独立行政法人農業・食品産業技術総合研究機構 Ｂｓｅ由来異常プリオン蛋白質の効率的増幅方法
JP5209711B2 (ja) 2008-05-28 2013-06-12 独立行政法人農業・食品産業技術総合研究機構 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
US20130109581A1 (en) * 2009-11-04 2013-05-02 David Peretz Positively charged species as binding reagents in the separation of protein aggregates from monomers
US20160077112A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of Misfolded Proteins
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
CN103460049B (zh) * 2011-01-18 2016-08-17 美国政府(由卫生和人类服务部的部长所代表) 扩增和检测朊病毒的方法
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (fr) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) Procédé de diagnostic de l'encéphalopathie spongiforme transmissible
WO2015160007A1 (fr) * 2014-04-17 2015-10-22 한림대학교 산학협력단 Procédé et dispositif de détection de protéine prion pathogène infinitésimale
WO2016040905A1 (fr) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Détection de protéine alpha-synucléine mal-repliée
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (fr) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Protéine de prion du campagnol roussâtre utilisée comme substrat à large spectre pour détection et discrimination de souches de prions basées sur une conversion induite par agitation en temps réel (rt-quic)
CA3062876A1 (fr) 2017-05-16 2018-11-22 Amprion, Inc. Detection de proteine tau a repliement anormal
US20190353669A1 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of Brain Injury or Neurological Disease using Tau Protein
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (fr) 2020-04-03 2021-10-07 Universität Zürich Procédé amélioré de détection de biomarqueurs dans un échantillon biologique

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
CA2268904A1 (fr) * 1996-10-15 1998-04-23 Imperial College Of Science, Technology And Medicine Diagnostic de l'encephalopathie spongiforme
AU5778400A (en) 1999-06-29 2001-01-31 Caprion Pharmaceuticals, Inc. Prion protein binding proteins and uses thereof
WO2001046714A1 (fr) * 1999-12-10 2001-06-28 Misonix Incorporated Ensemble emetteur d'ultrasons
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification

Also Published As

Publication number Publication date
JP2004503748A (ja) 2004-02-05
YU101202A (sh) 2006-01-16
EE200300005A (et) 2004-08-16
NO20030059D0 (no) 2003-01-06
DE60121958T2 (de) 2007-02-01
CY1109106T1 (el) 2014-07-02
CN1449497A (zh) 2003-10-15
BR0112262A (pt) 2003-05-20
HU228813B1 (en) 2013-05-28
EE05675B1 (et) 2013-08-15
IL153824A (en) 2010-02-17
EP1712920B1 (fr) 2009-03-25
SK18582002A3 (sk) 2003-05-02
KR100764981B1 (ko) 2007-10-09
HRP20030033A2 (en) 2004-02-29
ES2264691T3 (es) 2007-01-16
BG107498A (bg) 2003-11-28
SI1712920T1 (sl) 2009-10-31
IL153824A0 (en) 2003-07-31
EA200300126A1 (ru) 2003-06-26
AR029583A1 (es) 2003-07-02
HUP0301020A3 (en) 2010-03-29
HK1058065A1 (en) 2004-04-30
DK1299729T3 (da) 2006-12-04
RS51523B (sr) 2011-06-30
HUP0301020A2 (hu) 2003-07-28
HRP20030033B1 (hr) 2008-04-30
WO2002004954A2 (fr) 2002-01-17
DE60121958D1 (de) 2006-09-14
ATE426816T1 (de) 2009-04-15
JP4790966B2 (ja) 2011-10-12
PL211154B1 (pl) 2012-04-30
BRPI0112262B8 (pt) 2021-07-27
EP1299729A2 (fr) 2003-04-09
PT1712920E (pt) 2009-04-09
SK287768B6 (sk) 2011-09-05
PT1299729E (pt) 2006-10-31
ATE335204T1 (de) 2006-08-15
WO2002004954A3 (fr) 2002-10-24
PL360397A1 (en) 2004-09-06
BG66272B1 (bg) 2012-11-30
EP1712920A1 (fr) 2006-10-18
CA2413078A1 (fr) 2002-01-17
NZ523213A (en) 2005-01-28
US7351526B2 (en) 2008-04-01
MXPA03000226A (es) 2004-05-21
SI1299729T1 (sl) 2006-10-31
ES2322660T3 (es) 2009-06-24
CA2413078C (fr) 2010-08-03
AU6408901A (en) 2002-01-21
CZ200336A3 (cs) 2003-06-18
CZ304365B6 (cs) 2014-04-02
NO331624B1 (no) 2012-02-06
EA007391B1 (ru) 2006-10-27
NO20030059L (no) 2003-03-07
DE60138146D1 (de) 2009-05-07
AU2001264089B2 (en) 2006-03-30
KR20030036257A (ko) 2003-05-09
EP1299729B1 (fr) 2006-08-02
US20050064505A1 (en) 2005-03-24
BRPI0112262B1 (pt) 2016-08-09
CN1221807C (zh) 2005-10-05

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