DK0992580T3 - Epitoper på human T-celler, som er immundominante for hepatitis C-virus - Google Patents
Epitoper på human T-celler, som er immundominante for hepatitis C-virusInfo
- Publication number
- DK0992580T3 DK0992580T3 DK99116671T DK99116671T DK0992580T3 DK 0992580 T3 DK0992580 T3 DK 0992580T3 DK 99116671 T DK99116671 T DK 99116671T DK 99116671 T DK99116671 T DK 99116671T DK 0992580 T3 DK0992580 T3 DK 0992580T3
- Authority
- DK
- Denmark
- Prior art keywords
- epitopes
- hepatitis
- dominant
- immune
- virus
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108010076039 Polyproteins Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93402718 | 1993-11-04 | ||
EP94931000A EP0725824B1 (fr) | 1993-11-04 | 1994-10-28 | Epitopes de lymphocytes t humains immunodominants du virus de l'hepatite c |
PCT/EP1994/003555 WO1995012677A2 (fr) | 1993-11-04 | 1994-10-28 | Epitopes de lymphocytes t humains immunodominants du virus de l'hepatite c |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0992580T3 true DK0992580T3 (da) | 2005-07-11 |
Family
ID=8214764
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94931000T DK0725824T3 (da) | 1993-11-04 | 1994-10-28 | Immunodominante humane T-celleepitoper af hepatitis C virus |
DK99116671T DK0992580T3 (da) | 1993-11-04 | 1994-10-28 | Epitoper på human T-celler, som er immundominante for hepatitis C-virus |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94931000T DK0725824T3 (da) | 1993-11-04 | 1994-10-28 | Immunodominante humane T-celleepitoper af hepatitis C virus |
Country Status (11)
Country | Link |
---|---|
US (4) | US6555114B1 (fr) |
EP (4) | EP0992581B2 (fr) |
JP (2) | JPH09504534A (fr) |
AT (3) | ATE274578T1 (fr) |
AU (1) | AU698878B2 (fr) |
CA (1) | CA2175692A1 (fr) |
DE (3) | DE69432475T2 (fr) |
DK (2) | DK0725824T3 (fr) |
ES (2) | ES2197170T3 (fr) |
PT (2) | PT725824E (fr) |
WO (1) | WO1995012677A2 (fr) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2162557C (fr) | 1993-05-12 | 2004-09-28 | Amy J. Weiner | Motif conserve de la region e2/ns1 du virus de l'hepatite c |
US7070790B1 (en) * | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
ATE274578T1 (de) * | 1993-11-04 | 2004-09-15 | Innogenetics Nv | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
US5709995A (en) * | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
WO1995027733A1 (fr) * | 1994-04-08 | 1995-10-19 | The Government Of The United States Of America, Represented By The Department Of Health & Human Services | Peptide de noyau du virus de l'hepatite c pour la stimulation des lymphocytes t cytotoxiques et le diagnostic de l'exposition au vhc |
DE69841919D1 (de) | 1997-11-06 | 2010-11-11 | Innogenetics Nv | Multimere peptide, die auf dem hepatitis c virus hüllprotein basieren, für diagnostische verwendung und für impfzwecke |
HUP0101719A3 (en) | 1998-04-17 | 2006-05-29 | Innogenetics Nv | Improved immunodiagnostic assays using reducing agents |
AU3714499A (en) * | 1998-05-14 | 1999-11-29 | Pasteur Merieux Serums Et Vaccins | Hepatitis c virus mimotopes |
CA2331197A1 (fr) * | 1998-06-12 | 1999-12-23 | Aventis Pasteur | Mimotopes du virus hiv |
US7108855B2 (en) | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
CN1313864A (zh) * | 1998-06-24 | 2001-09-19 | 基因创新有限公司 | Hcv包膜蛋白颗粒∶用于疫苗接种的用途 |
ATE357526T1 (de) | 1998-08-21 | 2007-04-15 | Us Gov Health & Human Serv | Modifizierte hcv peptid-impfstoffe |
DE19908423A1 (de) * | 1999-02-26 | 2000-08-31 | Deutsches Krebsforsch | An der Entwicklung des ZNS beteiligtes Protein (TP) |
AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
EP1535628B1 (fr) * | 1999-11-24 | 2013-07-31 | Novartis Vaccines and Diagnostics, Inc. | Particule de type virus hbv/hcv |
RU2286172C2 (ru) | 2000-08-17 | 2006-10-27 | Трипеп Аб | Вакцины, содержащие рибавирин, и способы их использования |
US6680059B2 (en) * | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
CA2421445A1 (fr) * | 2000-09-01 | 2002-03-14 | Epimmune Inc. | Peptides de liaison aux hla et leurs utilisations |
GB0026094D0 (en) * | 2000-10-25 | 2000-12-13 | Imp College Innovations Ltd | Methods |
US8129349B2 (en) * | 2000-10-27 | 2012-03-06 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
US7402567B2 (en) * | 2000-10-27 | 2008-07-22 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
MXPA03009626A (es) | 2001-04-24 | 2004-06-30 | Innogenetics Nv | Construcciones y metodo para la expresion de proteinas recombinantes de la envoltura viral de hcv. |
FR2825093B1 (fr) * | 2001-05-28 | 2003-07-18 | Bio Merieux | Polypeptide reagissant avecles anticorps de patients infectes par vhc et utilisations |
FR2825363A1 (fr) * | 2001-05-31 | 2002-12-06 | Bio Merieux | Polypeptides reagissant avec les anticorps de patients infectes par vhc et utilisations |
US7736677B2 (en) * | 2001-06-20 | 2010-06-15 | Metaproteomics, Llc | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
JP2003064096A (ja) * | 2001-08-29 | 2003-03-05 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | C型肝炎ウイルス特異的細胞障害性t細胞認識エピトープ |
GB0126782D0 (en) * | 2001-11-07 | 2002-01-02 | Medical Res Council | Assay |
US20040126395A1 (en) * | 2001-12-18 | 2004-07-01 | Geert Maertens | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
CA2468690A1 (fr) * | 2001-12-18 | 2003-06-26 | Innogenetics N.V. | Proteines purifiees du virus de l'hepatite c utilisables en diagnostic et therapie |
AU2003301865A1 (en) * | 2002-05-16 | 2004-06-07 | The General Hospital Corporation | Epitopes of hepatitis c virus |
US8025873B2 (en) | 2002-06-20 | 2011-09-27 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
US8029803B2 (en) * | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
CN1678630A (zh) * | 2002-07-02 | 2005-10-05 | 希龙公司 | 具有修饰的ns3结构域的hcv融合蛋白 |
JP2006516955A (ja) * | 2002-11-08 | 2006-07-13 | イノジェネティックス・ナムローゼ・フェンノートシャップ | E1ペプチド及びns3ペプチドを含むhcvワクチン組成物 |
AU2003303889A1 (en) * | 2003-01-07 | 2004-08-30 | Biomerieux | Polypeptides f' of the hepatitis c virus, epitopes, and the diagnostic and therapeutic applications thereof |
US8007805B2 (en) * | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
KR100790646B1 (ko) * | 2004-07-03 | 2008-01-02 | 재단법인 목암생명공학연구소 | 세포매개 면역반응을 효과적으로 유도하는 hcv수퍼타입 에피토프, 그를 코딩하는 올리고뉴클레오타이드및 그의 용도 |
US7785875B2 (en) | 2004-07-03 | 2010-08-31 | Mogam Biotechnology Research Institute | Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same |
CU23470A1 (es) * | 2004-08-11 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c |
JP4980915B2 (ja) * | 2004-09-29 | 2012-07-18 | ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド | C型肝炎ウイルスのインヒビター |
EP1809773B1 (fr) * | 2004-10-18 | 2014-07-16 | Globeimmune, Inc. | Moyens therapeutiques a base de levure contre l'infection par hepatite c chronique |
WO2007031867A2 (fr) * | 2005-05-25 | 2007-03-22 | Tripep Ab | Gene de fusion ns3/4a non structurel de l'hepatite c |
CA2623329A1 (fr) * | 2005-10-13 | 2007-04-19 | Virexx Medical Corp. | Antigene chimere contenant un polypeptide du virus de l'hepatite c et un fragment fc destine a provoquer une reponse immunitaire |
CA2655059A1 (fr) * | 2006-06-20 | 2007-12-27 | Metaproteomics, Llc | Traitement d'un cancer par modulation de la proteine kinase au moyen d'acides hexahydro-isoalpha |
BRPI0713978A2 (pt) * | 2006-06-28 | 2012-11-27 | Statens Seruminstitut | expansão do repertório de células t para incluir epìtopos subdominantes através da vacinação com antìgeneos leberados como fragmentos de protéinas ou coquetéis de peptìdeo |
US20090214593A1 (en) * | 2007-08-16 | 2009-08-27 | Tripep Ab | Immunogen platform |
WO2009022236A2 (fr) * | 2007-08-16 | 2009-02-19 | Tripep Ab | Plate-forme immunogène |
ES2303496B1 (es) * | 2008-02-21 | 2009-07-07 | Fundacion Para El Estudio De Las Hepatitis Virales | Metodo analitico perfeccionado para la deteccion de hepatitis c oculta, aplicaciones del mismo y su correspondiente kit de diagnostico. |
JP2012503011A (ja) | 2008-09-19 | 2012-02-02 | グローブイミューン,インコーポレイテッド | 慢性c型肝炎ウイルス感染の免疫療法 |
CN103200961B (zh) | 2009-03-27 | 2017-10-27 | 中央研究院 | 抗病毒免疫的方法和组合物 |
US20120046188A1 (en) * | 2009-03-30 | 2012-02-23 | bioMerieux, SA | Solid Support for HCV Detection |
WO2012033142A1 (fr) * | 2010-09-08 | 2012-03-15 | 学校法人 埼玉医科大学 | Vaccin liposomal contre le virus de l'hépatite c |
TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
US9550811B2 (en) | 2010-12-02 | 2017-01-24 | Bionor Immuno As | Peptide scaffold design |
BR112013017488A2 (pt) | 2011-01-06 | 2017-08-01 | Bionor Immuno As | peptídeos imunogênicos multiméricos e monoméricos |
EP2859011B1 (fr) | 2012-06-06 | 2019-12-11 | Bionor Immuno AS | Peptides d'origine virale pour usage en tant qu'immunogènes or réactifs de dépistage |
WO2014129412A1 (fr) * | 2013-02-19 | 2014-08-28 | 国立大学法人神戸大学 | Bifidobacterium exprimant un polypeptide immunogène sur une couche de surface |
BR112015023355A8 (pt) | 2013-03-14 | 2018-01-30 | Abbott Lab | antígenos recombinantes ns3 de hcv e mutantes dos mesmos para detecção de anticorpos aprimorada. |
JP6739329B2 (ja) * | 2013-03-14 | 2020-08-12 | アボット・ラボラトリーズAbbott Laboratories | Hcvコア脂質結合ドメインモノクローナル抗体 |
CN105228649B (zh) | 2013-03-14 | 2019-01-18 | 雅培制药有限公司 | Hcv抗原-抗体组合测定和方法以及用在其中的组合物 |
EP3019192A4 (fr) | 2013-07-08 | 2017-07-05 | Nanjingjinsirui Science&Technology Biology Corporation | Compositions et procédés permettant d'augmenter la demi-vie d'une protéine dans un sérum |
CA3037813A1 (fr) | 2016-09-21 | 2018-03-29 | The Governors Of The University Of Alberta | Compositions immunogenes du virus de l'hepatite c et leurs procedes d'utilisation |
CN112601548A (zh) * | 2018-03-16 | 2021-04-02 | 艾伯塔大学理事会 | 丙型肝炎病毒肽组合物及其使用方法 |
CN109160942B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段502-518及其用途 |
WO2020154635A1 (fr) * | 2019-01-25 | 2020-07-30 | Senti Biosciences, Inc. | Constructions de fusion de régulation de fonction protéique |
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CA2047792C (fr) * | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Peptides synthetiques specifiques pour la detection des anticorps diriges contre le vhc, diagnostic de l'infection a vhc et sa prevention grace a des vaccins |
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SG77551A1 (en) * | 1992-03-06 | 2005-04-28 | Innogenetics Nv | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing |
US5756666A (en) * | 1993-10-19 | 1998-05-26 | Ajinomoto Co., Inc. | Peptides capable of inducing immune response to HIV |
ATE274578T1 (de) * | 1993-11-04 | 2004-09-15 | Innogenetics Nv | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
US5543657A (en) * | 1994-10-07 | 1996-08-06 | International Business Machines Corporation | Single layer leadframe design with groundplane capability |
-
1994
- 1994-10-28 AT AT99116672T patent/ATE274578T1/de not_active IP Right Cessation
- 1994-10-28 AU AU79932/94A patent/AU698878B2/en not_active Ceased
- 1994-10-28 EP EP99116672A patent/EP0992581B2/fr not_active Expired - Lifetime
- 1994-10-28 PT PT94931000T patent/PT725824E/pt unknown
- 1994-10-28 US US08/635,886 patent/US6555114B1/en not_active Expired - Fee Related
- 1994-10-28 ES ES94931000T patent/ES2197170T3/es not_active Expired - Lifetime
- 1994-10-28 DE DE69432475T patent/DE69432475T2/de not_active Revoked
- 1994-10-28 CA CA002175692A patent/CA2175692A1/fr not_active Abandoned
- 1994-10-28 PT PT99116671T patent/PT992580E/pt unknown
- 1994-10-28 AT AT99116671T patent/ATE290592T1/de not_active IP Right Cessation
- 1994-10-28 AT AT94931000T patent/ATE236981T1/de not_active IP Right Cessation
- 1994-10-28 DK DK94931000T patent/DK0725824T3/da active
- 1994-10-28 EP EP94931000A patent/EP0725824B1/fr not_active Revoked
- 1994-10-28 ES ES99116671T patent/ES2239819T3/es not_active Expired - Lifetime
- 1994-10-28 EP EP99116671A patent/EP0992580B1/fr not_active Revoked
- 1994-10-28 JP JP7513004A patent/JPH09504534A/ja active Pending
- 1994-10-28 DE DE69433971T patent/DE69433971T2/de not_active Expired - Fee Related
- 1994-10-28 EP EP99116673A patent/EP0979867A3/fr not_active Withdrawn
- 1994-10-28 DE DE69434295T patent/DE69434295T2/de not_active Revoked
- 1994-10-28 WO PCT/EP1994/003555 patent/WO1995012677A2/fr not_active Application Discontinuation
- 1994-10-28 DK DK99116671T patent/DK0992580T3/da active
-
1997
- 1997-11-19 US US08/974,685 patent/US6689368B1/en not_active Expired - Fee Related
- 1997-11-19 US US08/974,690 patent/US6613333B1/en not_active Expired - Fee Related
-
2003
- 2003-08-29 US US10/651,165 patent/US20040047877A1/en not_active Abandoned
-
2004
- 2004-02-12 JP JP2004034983A patent/JP2004194668A/ja active Pending
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