DE602004028122D1 - Pyrrolopyridin-2-carbonsäuren als hemmer der glycogenphosphorylase - Google Patents
Pyrrolopyridin-2-carbonsäuren als hemmer der glycogenphosphorylaseInfo
- Publication number
- DE602004028122D1 DE602004028122D1 DE602004028122T DE602004028122T DE602004028122D1 DE 602004028122 D1 DE602004028122 D1 DE 602004028122D1 DE 602004028122 T DE602004028122 T DE 602004028122T DE 602004028122 T DE602004028122 T DE 602004028122T DE 602004028122 D1 DE602004028122 D1 DE 602004028122D1
- Authority
- DE
- Germany
- Prior art keywords
- glycogen phosphorylase
- hemmer
- pyrrolopyridine
- carboxylic acids
- cardioprotectants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47237503P | 2003-05-21 | 2003-05-21 | |
| US55125604P | 2004-03-08 | 2004-03-08 | |
| PCT/US2004/016243 WO2004104001A2 (en) | 2003-05-21 | 2004-05-20 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phoshorylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004028122D1 true DE602004028122D1 (de) | 2010-08-26 |
Family
ID=33479321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004028122T Expired - Lifetime DE602004028122D1 (de) | 2003-05-21 | 2004-05-20 | Pyrrolopyridin-2-carbonsäuren als hemmer der glycogenphosphorylase |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1636224B1 (de) |
| JP (2) | JP2006528702A (de) |
| KR (1) | KR101120935B1 (de) |
| AT (1) | ATE473974T1 (de) |
| AU (1) | AU2004240946B8 (de) |
| BR (1) | BRPI0410445B1 (de) |
| CA (1) | CA2525502C (de) |
| DE (1) | DE602004028122D1 (de) |
| EA (1) | EA009215B1 (de) |
| IL (1) | IL171851A (de) |
| MA (1) | MA27809A1 (de) |
| MX (1) | MXPA05012547A (de) |
| NO (1) | NO332265B1 (de) |
| NZ (1) | NZ543482A (de) |
| UA (1) | UA84146C2 (de) |
| WO (1) | WO2004104001A2 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| KR100661118B1 (ko) * | 2003-11-12 | 2006-12-26 | 주식회사 엘지생명과학 | 멜라노코틴 수용체의 항진제 |
| JP2007527904A (ja) | 2004-03-08 | 2007-10-04 | プロシディオン・リミテッド | グリコーゲンホスホリラーゼ阻害剤としてのピロロピリジン−２−カルボン酸ヒドラジド化合物 |
| US7608627B2 (en) * | 2004-04-05 | 2009-10-27 | Takeda Pharmaceutical Company Limited | 6-azaindole compound |
| DE102004054634A1 (de) * | 2004-11-12 | 2006-05-18 | Schwarz Pharma Ag | Azaindolcarboxamide |
| GB0425919D0 (en) * | 2004-11-25 | 2004-12-29 | Prosidion Ltd | Indole-2-carboxylic acid amides |
| ES2309822T3 (es) | 2004-12-02 | 2008-12-16 | Prosidion Limited | Derivado de amida del acido pirrolopiridina-2-carboxilico util como inhibidor de la glucogeno-fosforilasa. |
| JP2008521873A (ja) | 2004-12-02 | 2008-06-26 | プロシディオン・リミテッド | ピロロピリジン−２−カルボン酸アミド類 |
| US20090298745A1 (en) * | 2004-12-02 | 2009-12-03 | Gerard Hugh Thomas | Treatment of Diabetes with Glycogen Phosphorylase Inhibitors |
| JP2009512717A (ja) * | 2005-10-21 | 2009-03-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルを調節するための誘導体 |
| BRPI0619985A2 (pt) * | 2005-12-16 | 2011-10-25 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, de obesidade e de diabetes do tipo ii em um ser humano ou animal e usos dos compostos |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| WO2008063842A2 (en) | 2006-11-02 | 2008-05-29 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain with agonists of ppar-gamma |
| FR2911605B1 (fr) | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique |
| DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035334A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007042154A1 (de) | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
| EP2340243B1 (de) | 2008-10-17 | 2014-10-08 | Boehringer Ingelheim International GmbH | Als mmp-13-inhibitoren geeignete heteroarylsubstituierte indolverbindungen |
| UY32940A (es) | 2009-10-27 | 2011-05-31 | Bayer Cropscience Ag | Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| ES2653215T3 (es) | 2011-05-31 | 2018-02-06 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina |
| ES2699773T3 (es) * | 2011-05-31 | 2019-02-12 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina |
| ES2642883T3 (es) | 2011-05-31 | 2017-11-20 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina |
| RU2015109064A (ru) | 2012-08-17 | 2016-10-10 | Байер Кропсайенс Аг | Амиды азаиндолкарбоновых и азаиндолтиокарбоновых кислот в качестве инсектицитов и акарицидов |
| CN103626825B (zh) * | 2013-09-30 | 2015-10-07 | 承德医学院 | 靶向肝脏的糖原磷酸化酶抑制剂胆酸类衍生物、其制备方法及医药用途 |
| CN105829296A (zh) | 2013-12-18 | 2016-08-03 | 巴斯夫欧洲公司 | 带有亚胺衍生的取代基的唑类化合物 |
| WO2021106988A1 (ja) * | 2019-11-27 | 2021-06-03 | 杏林製薬株式会社 | Ｇ９ａ阻害剤 |
| CN116507627A (zh) | 2020-11-02 | 2023-07-28 | 勃林格殷格翰国际有限公司 | 作为egfr抑制剂的经取代1h-吡唑并[4,3-c]吡啶及衍生物 |
| JP2024509936A (ja) * | 2021-03-10 | 2024-03-05 | ビンシア・バイオサイエンシーズ・インコーポレイテッド | Ｕｓｐ３０阻害剤及びその使用 |
| CN115894373B (zh) * | 2022-10-27 | 2025-08-01 | 常州大学 | N-取代苄基吡唑衍生物在作为β2肾上腺素受体调节剂、拮抗剂和激动剂的应用 |
| WO2023165168A1 (zh) * | 2022-10-27 | 2023-09-07 | 常州大学 | 吡唑类衍生物作为β2肾上腺素受体别构调节剂,拮抗剂和激动剂的应用 |
| CN115745891B (zh) * | 2022-11-10 | 2025-08-01 | 常州大学 | 吡唑衍生物在作为β2-肾上腺素受体拮抗剂的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4619915A (en) * | 1984-10-19 | 1986-10-28 | Pfizer Inc. | Peptide-substituted heterocyclic immunostimulants |
| IL88619A0 (en) * | 1987-12-15 | 1989-07-31 | Pfizer | Non-peptidic renin inhibitors |
| CN1131418A (zh) * | 1994-06-06 | 1996-09-18 | 株式会社绿十字 | 新型稠环羧酸化合物或其盐及其医药用途 |
| ATE206702T1 (de) * | 1995-06-06 | 2001-10-15 | Pfizer | Substituierte n-(indol-2-carbonyl)-glycinamide und derivate als glycogen phosphorylase inhibitoren |
| PT832066E (pt) * | 1995-06-06 | 2001-12-28 | Pfizer | N-substituido-(indole-2-carbonil)-amidas e derivados como inibidores de glicogenio-fosforilase |
| MY114711A (en) * | 1995-06-06 | 2002-12-31 | Pfizer | Substituted n-(indole-2-carbonyl)-b-alanmamides and derivatives as antidiabetic agents |
| US5952322A (en) * | 1996-12-05 | 1999-09-14 | Pfizer Inc. | Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors |
| GB9902047D0 (en) * | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| EP1088824B1 (de) * | 1999-09-30 | 2004-01-07 | Pfizer Products Inc. | Bicyclische Pyrrolylamide als Glycogenphosphorylase-Inhibitoren |
| GB0021831D0 (en) * | 2000-09-06 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| GB0202015D0 (en) * | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| DE60334015D1 (de) * | 2002-10-30 | 2010-10-14 | Merck Frosst Canada Ltd | Pyridopyrrolizin- und pyridoindolizinderivate |
-
2004
- 2004-05-20 DE DE602004028122T patent/DE602004028122D1/de not_active Expired - Lifetime
- 2004-05-20 JP JP2006533345A patent/JP2006528702A/ja not_active Withdrawn
- 2004-05-20 EA EA200501645A patent/EA009215B1/ru not_active IP Right Cessation
- 2004-05-20 UA UAA200510756A patent/UA84146C2/ru unknown
- 2004-05-20 WO PCT/US2004/016243 patent/WO2004104001A2/en active Search and Examination
- 2004-05-20 MX MXPA05012547A patent/MXPA05012547A/es active IP Right Grant
- 2004-05-20 AU AU2004240946A patent/AU2004240946B8/en not_active Ceased
- 2004-05-20 AT AT04753127T patent/ATE473974T1/de not_active IP Right Cessation
- 2004-05-20 BR BRPI0410445-5A patent/BRPI0410445B1/pt not_active IP Right Cessation
- 2004-05-20 EP EP04753127A patent/EP1636224B1/de not_active Expired - Lifetime
- 2004-05-20 NZ NZ543482A patent/NZ543482A/en not_active IP Right Cessation
- 2004-05-20 CA CA2525502A patent/CA2525502C/en not_active Expired - Fee Related
-
2005
- 2005-11-09 IL IL171851A patent/IL171851A/en active IP Right Grant
- 2005-11-10 NO NO20055305A patent/NO332265B1/no not_active IP Right Cessation
- 2005-11-21 MA MA28613A patent/MA27809A1/fr unknown
- 2005-11-21 KR KR1020057022252A patent/KR101120935B1/ko not_active Expired - Fee Related
-
2011
- 2011-08-09 JP JP2011174163A patent/JP5669691B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1636224A2 (de) | 2006-03-22 |
| JP2011252005A (ja) | 2011-12-15 |
| JP5669691B2 (ja) | 2015-02-12 |
| KR101120935B1 (ko) | 2012-03-05 |
| ATE473974T1 (de) | 2010-07-15 |
| WO2004104001A2 (en) | 2004-12-02 |
| UA84146C2 (ru) | 2008-09-25 |
| NO332265B1 (no) | 2012-08-13 |
| EP1636224B1 (de) | 2010-07-14 |
| CA2525502A1 (en) | 2004-12-02 |
| MXPA05012547A (es) | 2006-05-25 |
| NZ543482A (en) | 2009-02-28 |
| NO20055305L (no) | 2005-12-15 |
| BRPI0410445A (pt) | 2006-05-30 |
| BRPI0410445B1 (pt) | 2017-11-28 |
| CA2525502C (en) | 2012-12-18 |
| IL171851A (en) | 2011-08-31 |
| MA27809A1 (fr) | 2006-03-01 |
| JP2006528702A (ja) | 2006-12-21 |
| EA009215B1 (ru) | 2007-12-28 |
| WO2004104001A3 (en) | 2005-03-03 |
| AU2004240946B2 (en) | 2011-09-08 |
| NO20055305D0 (no) | 2005-11-10 |
| AU2004240946A1 (en) | 2004-12-02 |
| AU2004240946B8 (en) | 2012-01-12 |
| KR20060069792A (ko) | 2006-06-22 |
| EA200501645A1 (ru) | 2006-06-30 |
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