DE60121048D1 - PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE - Google Patents

PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE

Info

Publication number: DE60121048D1
Authority: DE; Germany
Prior art keywords: pyrazinoi1; böindolderivate; compounds; solvates; salts
Prior art date: 2000-06-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60121048T

Other languages

English (en)

Other versions

DE60121048T2 (de

Inventor

W Orme

Scott Sawyer

M Schultze

Claude-Marie Daugan

Francoise Gellibert

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lilly Icos LLC

Original Assignee

Lilly Icos LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-05-15

Publication date

2006-08-03

2001-05-15 Application filed by Lilly Icos LLC filed Critical Lilly Icos LLC

2006-08-03 Application granted granted Critical

2006-08-03 Publication of DE60121048D1 publication Critical patent/DE60121048D1/de

2007-01-25 Publication of DE60121048T2 publication Critical patent/DE60121048T2/de

2021-05-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Pregnancy & Childbirth (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE60121048T 2000-06-23 2001-05-15 PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE Expired - Lifetime DE60121048T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US21364700P	2000-06-23	2000-06-23
US213647P		2000-06-23
PCT/US2001/015935 WO2002000656A2 (en)	2000-06-23	2001-05-15	Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives

Publications (2)

Publication Number	Publication Date
DE60121048D1 true DE60121048D1 (de)	2006-08-03
DE60121048T2 DE60121048T2 (de)	2007-01-25

Family

ID=22795930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60121048T Expired - Lifetime DE60121048T2 (de)	2000-06-23	2001-05-15	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE

Country Status (10)

Country	Link
US (1)	US6911542B2 (de)
EP (1)	EP1366049B1 (de)
JP (1)	JP4169149B2 (de)
AT (1)	ATE330958T1 (de)
AU (1)	AU2001261707A1 (de)
CA (1)	CA2412594C (de)
DE (1)	DE60121048T2 (de)
ES (1)	ES2269401T3 (de)
MX (1)	MXPA02012472A (de)
WO (1)	WO2002000656A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2004107323A (ja) *	2002-07-26	2004-04-08	Nippon Nohyaku Co Ltd	新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
WO2004011429A1 (ja) *	2002-07-26	2004-02-05	Nihon Nohyaku Co., Ltd.	新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
BRPI0506994A (pt)	2004-01-22	2007-07-03	Pfizer	derivados de triazol que inibem a atividade antagonista da vasopressina
JP5070052B2 (ja)	2004-08-17	2012-11-07	ザ・ジョンズ・ホプキンス・ユニバーシティ	Ｐｄｅ５阻害剤組成物及び心臓疾患を治療する方法
CN101155809A (zh) *	2005-04-12	2008-04-02	特瓦制药工业有限公司	他达那非中间体的制备
EP2938343B1 (de)	2012-12-21	2018-09-12	Mayo Foundation For Medical Education And Research	Verfahren und materialien zur behandlung von kalkaortenklappenstenose
WO2015054132A1 (en) *	2013-10-07	2015-04-16	Millennium Pharmaceuticals, Inc.	Inhibitor of breast cancer resistance protein (bcrp)
CN106279164B (zh) *	2015-06-26	2019-11-01	重庆迪康尔乐制药有限公司	5型磷酸二酯酶抑制剂及其应用
ES2774048T3 (es) *	2015-06-26	2020-07-16	Chongqing Dikang Erle Pharma Co Ltd	Nuevo inhibidor de la fosfodiesterasa de tipo 5 y su aplicación
CN105384740A (zh) *	2015-12-18	2016-03-09	海南通用康力制药有限公司	一种制备他达拉非的中间体高纯度晶体及制备方法
MX2021012409A (es)	2019-04-10	2021-11-12	Mayo Found Medical Education & Res	Metodos y materiales para el tratamiento dependiente del genero de la disfuncion cardiovascular.
CN119390695A (zh) *	2024-12-31	2025-02-07	威胜生物医药(苏州)股份有限公司	一种水溶性氨基他达那非衍生物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9401090D0 (en) *	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
GB9514464D0 (en) *	1995-07-14	1995-09-13	Glaxo Lab Sa	Medicaments

2001
- 2001-05-15 ES ES01935629T patent/ES2269401T3/es not_active Expired - Lifetime
- 2001-05-15 MX MXPA02012472A patent/MXPA02012472A/es active IP Right Grant
- 2001-05-15 DE DE60121048T patent/DE60121048T2/de not_active Expired - Lifetime
- 2001-05-15 EP EP01935629A patent/EP1366049B1/de not_active Expired - Lifetime
- 2001-05-15 AT AT01935629T patent/ATE330958T1/de not_active IP Right Cessation
- 2001-05-15 WO PCT/US2001/015935 patent/WO2002000656A2/en active IP Right Grant
- 2001-05-15 JP JP2002505780A patent/JP4169149B2/ja not_active Expired - Fee Related
- 2001-05-15 CA CA002412594A patent/CA2412594C/en not_active Expired - Fee Related
- 2001-05-15 US US10/297,682 patent/US6911542B2/en not_active Expired - Fee Related
- 2001-05-15 AU AU2001261707A patent/AU2001261707A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2001261707A1 (en)	2002-01-08
WO2002000656A3 (en)	2003-10-02
US20030225094A1 (en)	2003-12-04
JP2004513072A (ja)	2004-04-30
CA2412594A1 (en)	2002-01-03
JP4169149B2 (ja)	2008-10-22
ATE330958T1 (de)	2006-07-15
DE60121048T2 (de)	2007-01-25
US6911542B2 (en)	2005-06-28
MXPA02012472A (es)	2004-01-26
CA2412594C (en)	2009-03-17
EP1366049B1 (de)	2006-06-21
ES2269401T3 (es)	2007-04-01
WO2002000656A2 (en)	2002-01-03
EP1366049A2 (de)	2003-12-03

Legal Events

Date	Code	Title	Description
2007-07-12	8364	No opposition during term of opposition

Publication	Publication Date	Title
DE60112974D1 (en)	2005-09-29	Carbolinderivate
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
DE60216233D1 (en)	2007-01-04	Carbolinderivate
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
MXPA02012659A (es)	2003-09-22	Derivados de pirazindiona condensados.
GB9514473D0 (en)	1995-09-13	Chemical compounds
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
GB9801690D0 (en)	1998-03-25	Therapeutic agents
PT1109812E (pt)	2005-09-30	Pirrolobenzodiazepinas
DE60230127D1 (de)	2009-01-15	Inhibitoren von integrin alpha-v-beta-6
MXPA03009750A (es)	2004-06-30	Compuestos quimicos.
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
DE60121048D1 (de)	2006-08-03	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
DE60122559D1 (de)	2006-10-05	Indolderivate als pde5-inhibitoren
DE60110124D1 (de)	2005-05-19	Kondensierte pyrazindionderivate als pde inhibitoren
CA2445620A1 (en)	2002-12-12	Tetracyclic compounds as pde5-inhibitors
CY1105981T1 (el)	2011-04-06	Ενωσεις 5-πυριδυλ-1,3-αζολιου, μεθοδοι παρασκευης αυτων και χρηση αυτων