CN205364554U - Bio -printer temperature control system and bio -printer - Google Patents

Abstract

The utility model provides a bio -printer temperature control system and bio -printer. The utility model provides a bio -printer temperature control system, including runner temperature control system (3) and bioprinting material container (4), runner temperature control system (3) are used for controlling the temperature of the runner between export and the bio -printer's of bio -printer bioprinting material container (4) nozzle (5), so that the required temperature of the temperature of runner and bioprinting material is consistent. The utility model discloses a temperature control system can realize the control by temperature change to the bioprinting material, improves the survival rate of printing the material, guarantees to print the biological function of material.

Description

Bioprinter temperature control system and bioprinter

technical field

The utility model relates to the technical field of biological printers, in particular to a biological printer temperature control system and a biological printer.

Background technique

Bio-3D printing refers to the technology of printing biological materials (including natural biological materials and synthetic biological materials or cell solutions) into designed three-dimensional structures through the principles and methods of 3D printing. Since the printing materials of biological 3D printing are biological materials, compared with ordinary 3D printing technology, one of the characteristics of bioprinting is that it needs to provide suitable conditions for the printing materials to survive, grow and have good biological functions, and temperature is one of them. An important control indicator.

At present, bioprinters are usually equipped with a temperature control system, which is used to control the temperature of the bioprinting material container, which usually includes a heat exchange component and a heat dissipation device, wherein the heat exchange component is used to communicate with the bioprinting material container through a heat conduction sleeve. The heat exchange is performed, and the heat dissipation device is used to realize the heat exchange between the heat exchange component and the environment. However, the existing bioprinter temperature control system has the following problems:

(1) For the existing bioprinter temperature control system, biomaterials are prone to clogging. One of the reasons is that the temperature control system of the bioprinter can only control the temperature of the bioprinting material container, but cannot control the temperature of the nozzle part and the flow channel part. At the same time, because the biomaterials have a certain viscosity, the printing materials are easy to change in temperature. Blockages in the nozzles and flow channels that cannot be effectively controlled will become more obvious as the viscosity of the printing material increases, thereby affecting the printing efficiency of the entire bioprinter, especially when the printing plane is non-planar. The problem is more obvious when using longer nozzles to suit printing needs. In addition, the existing bioprinter temperature control system is difficult to apply to printing materials whose flow characteristics change with temperature changes, resulting in relatively large limitations in the selection of printing materials for existing bioprinters.

(2) The existing bioprinter temperature control system is difficult to achieve uniform temperature control of the bioprinting container. In the prior art, due to space constraints and other reasons, the heat exchange components cannot fully cover the heat conduction sleeve, and blind areas that cannot be covered by the heat exchange components are prone to appear on the heat conduction sleeve. Such a structure is likely to cause uneven heating of the bioprinting material container , leading to problems such as uneven heating of biological materials, leading to increased risks of decreased survival rate of biological materials and decreased biological functions; and if all the heat exchange components are covered on the heat conduction sleeve, the heat dissipation device on the heat exchange components will be difficult to layout. Usually, it can only be attached to the outside of the whole structure, which makes the structure protrude as a whole, which is not conducive to the overall structure layout.

Utility model content

A technical problem to be solved by the utility model is: the existing bioprinter temperature control system does not control the temperature of the biological material in the flow channel from the bioprinting container to the nozzle, resulting in poor fluidity of the biological material in the flow channel There is a problem of clogging, and since the temperature of the biomaterial in the flow channel is not controlled, there is a risk of a lower survival rate of the biomaterial, a decrease in biological function, and the like.

In order to solve the above technical problems, the utility model provides a flow path temperature control system and a bioprinting material container, the flow path temperature control system is used to control the gap between the outlet of the bioprinting material container of the bioprinter and the nozzle of the bioprinter The temperature of the flow channel, so that the temperature of the flow channel is consistent with the temperature required by the bioprinting material.

Further, the bioprinter temperature control system includes a container temperature control system, and the container temperature control system includes a heat exchange device, and the heat exchange device is used to perform heat exchange with the bioprinting material container to control the temperature of the bioprinting material container. The temperature is consistent with the temperature required by the bioprinting material contained therein. The temperature control system of the bioprinter also includes a first vapor chamber arranged between the bioprinting material container and the heat exchange device. A vapor chamber is used to achieve uniform heat transfer between the heat exchange device and the bioprinting material container.

Further, the heat exchanging device includes a heat exchanging component and a cooling device, the heat exchanging component can heat and cool the bio-printing material container, and the first vapor chamber is arranged between the bio-printing material container and the Between the first side of the heat exchange component, the second side of the heat exchange component is connected to the heat dissipation device, and the heat dissipation device is used to realize heat transfer between the heat exchange component and the environment.

Further, the container temperature control system further includes a second vapor chamber, the second vapor chamber is arranged between the second side of the heat exchange component and the heat sink, and is used to realize the heat exchange Uniform heat transfer between components and the heat sink.

Further, the heat dissipation device includes a heat sink set and a heat dissipation fan, the heat sink set is connected to the second side of the heat exchange component, and the heat dissipation fan is used to achieve heat dissipation between the heat sink set and the environment. In other words, the second vapor chamber is disposed between the second side of the heat exchange component and the heat sink set, so as to achieve uniform heat transfer between the heat exchange component and the heat sink set.

Further, the air outlet of the cooling fan is set away from the printing platform of the bioprinter.

Further, the heat dissipation fan is a speed-regulating fan, and the container temperature control system further includes a heat dissipation temperature detection and control device, which is used to detect the temperature of the heat dissipation fin group and can The difference between the temperature of the group and the ambient temperature is used to control whether the cooling fan is turned on and to adjust the speed of the cooling fan.

Further, the container temperature control system also includes a container temperature detection and control device, the container temperature detection and control device is used to detect the temperature of the bioprinting material container and feed it back to the heat exchange device to form an Closed-loop control of material container temperature.

Further, the bioprinter temperature control system also includes a nozzle temperature control system, the nozzle temperature control system is used to control the temperature of the nozzle of the bioprinter, so that the temperature of the nozzle is consistent with the temperature required by the bioprinting material consistent.

Further, the nozzle temperature control system includes a nozzle heat conduction block, and the nozzle heat conduction block is arranged on the outer periphery of the nozzle.

Further, the flow channel temperature control system includes a flow channel heat conduction block, and the flow channel heat conduction block is arranged on the periphery of the flow channel between the outlet of the bioprinting material container and the nozzle.

Further, the bioprinter temperature control system includes two independent container temperature control systems, one of which is used to control the temperature of the first material container of the bioprinting material container, and the other container The temperature control system is used to control the temperature of the second material container of the bioprinting material container.

Further, the heat exchange component includes a semiconductor cooling chip.

The utility model also provides a biological printer, including the aforementioned temperature control system of the biological printer.

Further, a bioprinting material container is included, the bioprinting material container includes a first material container and a second material container, the nozzle of the bioprinter is connected to the outlet of one of the first material container and the second material container The nozzle of the bioprinter is directly connected to the outlet of the other one of the first material container and the second material container through the flow channel, and a flow channel heat conduction block is arranged on the outer periphery of the flow channel.

Further, a nozzle heat conduction block is provided on the outer periphery of the nozzle, and the flow channel passes through the flow channel heat conduction block and the nozzle heat conduction block sequentially from the outlet to communicate with the nozzle.

Further, a heat insulating layer is provided on the outer periphery of the flow channel in the nozzle heat conduction block for isolating heat from the nozzle heat conduction block.

Further, the heat insulation layer is arranged between the flow channel and the heat conduction block of the nozzle.

The bioprinter temperature control system provided by the utility model can realize the temperature control of the flow path between the bioprinting material container and the nozzle by setting the flow path temperature control system, so that it can effectively solve the problem that the current printing material is easy to get stuck in the flow path. The problem of clogging occurs, and the printing efficiency of the bioprinter is effectively improved.

In addition, by setting a vapor chamber between the bioprinting material container and the heat exchange device, uniform temperature control of the bioprinting material container can be achieved, thereby improving the survival rate of the printing material and ensuring the biological function of the printing material; All the heat exchange components are covered on the bio-printing material container to achieve uniform temperature control of the entire bio-printing material container, thereby facilitating the layout of the cooling device and making the overall structure more compact and beautiful.

In addition, the utility model can realize the temperature control of the nozzle by setting the nozzle temperature control system, so that it can effectively solve the problem that the current printing material is easy to be blocked at the nozzle, especially when the printing plane is non-planar, in order to better adapt to When a longer nozzle is used for printing requirements, the effect is more obvious, which effectively improves the printing efficiency of the bioprinter.

The utility model provides a temperature control system for the bioprinter, which is used to control the temperature of the bioprinter. The temperature control makes the temperature of the bioprinter more uniform, helps to provide the survival rate of cells and biological functions, and can make the printing target more ideal. .

Other features and advantages of the present invention will become clear through the following detailed description of exemplary embodiments of the present invention with reference to the accompanying drawings.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the accompanying drawings that need to be used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the accompanying drawings in the following description These are only some embodiments of the utility model, and those skilled in the art can also obtain other drawings based on these drawings without any creative effort.

Fig. 1 shows a schematic structural diagram of a bioprinter temperature control system installed on a bioprinter according to an embodiment of the present invention.

FIG. 2 shows a front view of the embodiment shown in FIG. 1 .

FIG. 3 shows a side view of FIG. 2 .

FIG. 4 shows the A-A sectional view of FIG. 3 .

In the picture:

1. Container temperature control system; 11. Thermal sleeve; 12. Semiconductor refrigeration device; 13. Heat dissipation device; 131. Heat sink group; 132. Cooling fan; 14. First vapor chamber; 15.

The second vapor chamber; 16. The first connecting frame; 17. The second connecting frame; 18. The first temperature sensor; 19. The second temperature sensor;

2. Nozzle temperature control system; 21. Nozzle heat conduction block;

3. Runner temperature control system; 31. Runner heat conduction block;

4. Bioprinting material container; 41. The first material container; 42. The second material container;

5. Nozzle; 6. Mounting plate; 7. Heat shield.

detailed description

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. example. The following description of at least one exemplary embodiment is merely illustrative in nature, and in no way serves as any limitation of the invention and its application or use. Based on the embodiments of the present utility model, all other embodiments obtained by persons of ordinary skill in the art without carrying out creative work belong to the scope of protection of the present utility model.

In the description of the present utility model, it should be understood that orientation words such as "front, back, up, down, left, right", "horizontal, vertical, vertical, horizontal" and "top, bottom" etc. indicate The orientation or positional relationship is generally based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the utility model and simplifying the description. In the absence of a contrary statement, these orientation words do not indicate or imply the referred device Or components must have a specific orientation or be constructed and operated in a specific orientation, so it cannot be construed as limiting the protection scope of the present utility model; the orientation words "inside and outside" refer to the inside and outside relative to the outline of each component itself.

In the description of the present utility model, it should be understood that the use of words such as "first" and "second" to define parts is only for the convenience of distinguishing corresponding parts. If there is no other statement, the above words do not special meaning, so it cannot be interpreted as limiting the protection scope of the present utility model.

In order to solve the technical problem that printing materials are prone to clogging at the nozzle and flow channel in the prior art, Fig. 1-4 shows a schematic structural diagram of the temperature control system of the bioprinter in an embodiment of the present invention. The bioprinter temperature control system includes a flow channel temperature control system 3, and the flow channel temperature control system 3 is used to control the temperature of the flow channel between the outlet of the bioprinting material container 4 and the nozzle 5, so that the temperature of the flow channel is the same as that of the printing material. The required temperature is consistent, and the flow path here should not be understood as including any flow path inside the nozzle 5 . In this way, the bioprinter temperature control system of the utility model can ensure that the temperature of the flow channel also meets the requirements of printing materials, thereby ensuring the unimpeded flow of printing materials and improving the printing efficiency of the bioprinter.

The biological printer temperature control system of the present utility model includes a container temperature control system 1, and the container temperature control system 1 includes a heat exchange device, which is used for heat exchange with the bio-printing material container 4 to control the temperature of the bio-printing material container 4 Consistent with the temperature required by the printing material contained in it, it also includes a first thermal chamber 14 arranged between the bio-printing material container 4 and the heat exchange device. The first thermal chamber 14 is used to realize the heat exchange device and the biological Uniform heat transfer between printing material containers 4.

The bioprinter temperature control system provided by the utility model can realize the uniform temperature control of the bioprinting material container 4 by arranging the first soaking plate 14 between the bioprinting material container 4 and the heat exchange device, thereby improving the temperature of the printing material. The survival rate of the bioprinting material is guaranteed to ensure the biological function of the printing material, and it can also prevent the printing material from clogging at the bioprinting material container 4 and improve the working reliability of the bioprinter.

As an embodiment of the heat exchange device, the heat exchange device may include a heat exchange component and a heat dissipation device 13, wherein the heat exchange component can heat and cool the bioprinting material container 4, and the heat dissipation device 13 is used to realize the heat exchange component and the cooling device 13. Heat transfer between environments, so that when the temperature of the bio-printing material container 4 is higher than the temperature required by the printing material, the heat exchange component can absorb heat from the bio-printing material container 4, and cool the bio-printing material container 4 to the required temperature of the printing material. required temperature; and when the temperature of the bioprinting material container 4 is lower than the temperature required by the printing material, the heat exchange component can transfer heat to the bioprinting material container 4, and the bioprinting material container 4 is heated to the temperature required by the printing material . It can be seen that the heat exchange device in this embodiment is more flexible in controlling the temperature of the bio-printing material container 4, it can heat or cool the bio-printing material container 4 according to the actual situation, the control accuracy is higher, and it can meet the temperature requirements of different printing materials. need.

In order to further realize a more uniform heat transfer between the heat exchange component and the heat sink 13, a second vapor chamber 15 may also be provided between the second side of the heat exchange component and the heat sink 13, based on the second heat chamber 15 The heat in the environment can be more evenly transferred between the heat sink 13 and the second side of the heat exchange component, reducing the temperature difference between the two sides of the heat exchange component and further improving the heat transfer effect of the heat exchange component.

Such a structure is also conducive to the overall structural layout. Normally, if the heat sink 13 is completely covered on the heat exchange components, the heat dissipation fan of the heat sink 13 will be attached to the outside of the entire structure, so that the entire structure is convex; In the embodiment, by setting the second vapor chamber 15 between the heat sink 13 and the heat exchange component, it is possible to reduce the heat exchange blind area on the heat exchange component and provide an assembly space for the cooling fan, so as to avoid the overall structure from protruding.

In addition, in order to further solve the technical problem that printing materials are prone to clogging at the nozzle in the prior art, the temperature control system of the biological printer of the present invention can also include a nozzle temperature control system 2, wherein the nozzle temperature control system 2 is used to control biological The temperature of the nozzle 5 of the printer is adjusted so that the temperature of the nozzle 5 is consistent with the temperature required by the printing material.

In this way, the biological printer temperature control system of the utility model not only ensures that the temperature at the flow channel meets the requirements of the printing materials, but also ensures that the temperature at the nozzle 5 and the bio-printing material container 4 meets the requirements of the printing materials, thereby being able to Ensure the smooth flow of printing materials, improve the printing efficiency of bioprinters, and because the printing materials can be in a suitable temperature environment during the entire printing process, it can also ensure that the printing materials always have good biological properties, thereby improving biological performance. The performance of the printed product.

The bioprinter temperature control system of the present invention will be further described below in conjunction with the embodiments described in FIGS. 1-4 . In this embodiment, the bioprinter used in the temperature control system of the bioprinter has a bioprinting material container 4 comprising a first material container 41 and a second material container 42, and the first material container 41 and the second material container 42 are heat-insulated The plate 7 is connected to the mounting plate 6 of the bioprinter, the nozzle 5 of the bioprinter is directly connected to the outlet of the first material container 4 , and the outlet of the second material container 42 communicates with the nozzle 5 through the auxiliary material flow channel 421 . The first material container 41 can be used as a main material container for holding a main material (also known as bioink), and the second material container 42 can be used as an auxiliary material container for holding an auxiliary material (such as a hydrogel). For example, the auxiliary material can be It is used to wrap the main material to avoid the main material being damaged by mechanical force during the printing process. Of course, the main material and the auxiliary material can also be combined in other ways, such as mixing.

As shown in Figures 1-4, in this embodiment, the bioprinter temperature control system includes two independent container temperature control systems 1, a set of nozzle temperature control systems 2 and a set of flow channel temperature control systems 3, wherein one The container temperature control system 1 is used to control the temperature of the first material container 41, the other container temperature control system 1 is used to control the temperature of the second material container 42, and the nozzle temperature control system 2 is used to control the temperature of the nozzle 5 , the flow channel temperature control system 3 is used to control the temperature of the auxiliary material flow channel 421 . By arranging two independent container temperature control systems to control the temperature of the first material container 41 and the second material container 42 respectively, different demands on temperature of main materials and auxiliary materials with different characteristics can be met.

Because in this embodiment, the structures of the two sets of container temperature control systems 1 are basically the same, therefore, only the container temperature control system 1 arranged at the second material container 42 is used as an example to carry out the container temperature control system 1. illustrate.

As shown in FIG. 2 and FIG. 4 , in this embodiment, the container temperature control system 1 includes a heat conduction jacket 11 , a semiconductor refrigeration system used as a heat exchange device, a first vapor chamber 14 and a second vapor chamber 15 . Wherein, the semiconductor refrigeration system includes a semiconductor refrigeration device 12 and a heat dissipation device 13, the heat conduction sleeve 11 is sleeved on the outer periphery of the second material container 42, and the first side of the semiconductor refrigeration device 12 is connected to the heat conduction sleeve 14 through the first heat soaking plate 14, The second side of the semiconductor refrigeration device 12 is connected to the heat sink 13 through the second vapor chamber 15 .

The semiconductor refrigeration system can be used as both a heat source and a cold source. According to the semiconductor refrigeration theory, applying a DC voltage to both sides of the semiconductor refrigeration sheet in the semiconductor refrigeration system will generate a direct current, which will cause one side of the semiconductor refrigeration sheet to heat and the other side to cool. The side that generates heat is often called the "hot side" and the side that cools is called the "cold side". The semiconductor refrigeration sheet has a control terminal. After sending instructions to the control terminal, the voltage polarity on both sides of the semiconductor refrigeration sheet can be reversed, so that the current flows in the opposite direction, so as to realize the mutual conversion between the cold surface and the hot surface of the semiconductor refrigeration sheet, that is, it can To realize the mutual conversion of the cooling and heating functions of the semiconductor refrigeration system, in addition to the exchange of cold and hot surfaces, it can also achieve precise temperature control (accuracy of 0.01 degrees) according to requirements. It can be seen that using the semiconductor refrigeration system as the heat exchange device of the present invention can conveniently and effectively realize the heating or cooling of the second material container 42 to meet the different temperature requirements of various bioprinting materials.

In this embodiment, a container temperature detection and control device may be provided in the container temperature control system 1, and the semiconductor refrigeration system is controlled to switch between the heating working state and the cooling working state through the container temperature detecting and controlling device. As shown in Figure 4, in this embodiment, the container temperature detection and control device includes a control system (not shown in the figure) and a first temperature sensor 18 arranged on the heat conduction sleeve 11, and the first temperature sensor 18 is used to detect The temperature of the heat conduction sleeve 11 is transmitted to the control system. Since the temperature of the heat conduction sleeve 11 is consistent with the temperature of the corresponding second material container 42, the first temperature sensor 18 can detect the temperature of the second material container 42 and transmit it to the control system. The control system controls the working state of the semiconductor refrigeration system by comparing the temperature of the second material container 42 with the temperature required by the auxiliary material (usually preset in the control system), so as to realize the control of the temperature of the second material container 42 Closed-loop control to improve temperature control accuracy. After the first temperature sensor 18 detects that the temperature of the first material container 41 and the second material container 42 reaches the temperature required by the biological material, it can be controlled to add corresponding materials to the first material container 41 and the second material container 42 respectively. .

The first vapor chamber 14 arranged on the first side of the semiconductor refrigeration device 12 can achieve uniform heat transfer through the mutual conversion of the gas-liquid two phases inside the semiconductor refrigeration device 12, so that the gap between the semiconductor refrigeration device 12 and the second material container 42 The heat transfer is more uniform and efficient, thereby effectively preventing the phenomenon of uneven heat transfer caused by the inability of the semiconductor refrigeration device 12 to fully cover the heat conduction sleeve 11, and because it is not necessary to cover the entire heat conduction sleeve 11 with the semiconductor refrigeration sheet, the structural design and The space layout is also simpler and more compact; and the second vapor chamber 15 arranged on the second side of the semiconductor refrigeration device 12 can make the heat transfer between the semiconductor refrigeration device 12 and the environment more uniform, reducing the size of the first side of the semiconductor refrigeration device 12 and The temperature difference on the second side, because there is a reverse heat transfer process between the cold surface and the hot surface of the semiconductor refrigeration device, and the greater the temperature difference between the cold and hot surfaces, the more obvious this reverse heat transfer effect, and once the forward heat transfer is transferred When the heat of the semiconductor refrigeration device 12 is equal to the heat transferred by the reverse heat transfer, the temperature of the cold surface and the hot surface will no longer change, which will affect the cooling or heating effect of the semiconductor refrigeration device 12. The temperature difference between the first side and the second side of the device 12 can weaken the effect of reverse heat transfer, and give full play to the cooling or heating effect of the semiconductor refrigeration device 12 .

The existing semiconductor refrigeration device 12 usually only includes one semiconductor refrigeration chip. In order to make the semiconductor refrigeration device 12 have higher heat transfer power, the semiconductor refrigeration device 12 of the present invention may include at least two semiconductor refrigeration chips. As shown in Figure 4, in this embodiment, the semiconductor refrigeration device 12 includes three semiconductor refrigeration chips, the benefit of such arrangement is that, on the one hand, the power of heating or cooling can be effectively increased due to the increase of the number of semiconductor refrigeration chips, Improve the heat transfer effect; on the other hand, the three semiconductor cooling chips can be arranged in parallel, which can improve its working reliability. Even if one of the semiconductor cooling chips fails, the remaining semiconductor cooling chips can still work normally, ensuring heating or cooling. The normal operation of the refrigeration process. In addition, it can be seen from FIG. 4 that there are certain gaps between the three peltiers in this embodiment, which facilitates the connection and installation of circuits.

The heat dissipation device 13 can adopt a water cooling heat dissipation device, and can also adopt an air cooling heat dissipation device. As shown in Figures 2-4, in this embodiment, the heat dissipation device 13 adopts an air-cooled heat dissipation device, which includes a heat sink set 131 and a heat dissipation fan 132, wherein the heat sink set 131 is connected to the mounting plate 6 through the first bracket 16 , and it is connected to the second side of the semiconductor refrigeration device 12 through the second vapor chamber 15, and the cooling fan 132 is arranged on the lower part of the cooling fin group 131 through the second bracket 17, so that the cooling fin group 131 and the semiconductor refrigeration device 12 The heat transfer between the second sides of the heat sink 13 can be carried out evenly through the second vapor chamber 15, and the heat dissipation fan 132 can realize the heat transfer between the heat sink group 131 and the environment, so that the heat sink 13 can realize the connection between the semiconductor refrigeration device and the environment. heat transfer between them. In addition, holes (not shown) transversely penetrating through the heat sinks may be provided on the heat sinks of the heat sink set 131 to increase the heat dissipation area and improve the heat dissipation efficiency.

In this embodiment, the air outlet of the cooling fan 132 is away from the printing platform of the bioprinter, that is, the air outlet of the cooling fan 132 faces upwards in FIGS. The printing platform, thereby preventing the influence on the characteristics of the biological material on the printing platform.

Further, in order to save energy and achieve precise temperature control, the cooling fan 132 of the present invention can use a speed-adjustable fan to control whether the cooling fan 132 is turned on and adjust the cooling fan 132 according to the difference between the temperature of the cooling fin group 131 and the ambient temperature. The rotating speed of the cooling fan 132 can make the working state of the cooling fan 132 conform to the actual needs, so as to avoid the waste of energy. In order to achieve this purpose, the container temperature control system 1 of the present utility model can also include a heat dissipation temperature detection and control device, which is used to detect the temperature of the heat dissipation fin group 131 and according to the temperature of the heat dissipation fin group 131 and the temperature of the environment. The difference is used to control whether the cooling fan 132 is turned on and to adjust the speed of the cooling fan 132 . In the embodiment shown in Figure 4, the heat dissipation temperature detection control device includes a second temperature sensor 19 and a control system arranged on the heat sink group 131, and the second temperature sensor 19 can detect the temperature of the heat sink group 131 and feed back To the control system, the control system compares the temperature of the heat sink group 131 with the ambient temperature, and controls whether the heat dissipation fan 132 works and the rotating speed during work according to the difference between the two. For example, it can work in the container temperature control system 1, And when the temperature difference ΔT between the temperature of the heat sink group 131 and the ambient temperature is greater than the set value T0, start the cooling fan 132 and make it run at a speed of R=(ΔT/30)×R0, where R0 is the rated speed of the fan; and When the container temperature control system 1 is not working or when the temperature difference ΔT between the temperature of the cooling fin group 131 and the ambient temperature is less than the set value T0, the cooling fan 132 can be controlled not to start. The control system here can be the same control system as the control system of the container temperature detection and control device, for example, the existing control system of the bioprinter can be used to realize the corresponding functions.

The working process of the container temperature control system 1 of this embodiment is as follows:

(1) When the temperature of the second material container 42 was lower than the required temperature of the auxiliary material, the semiconductor refrigeration system was in a heating state, and the first side of the semiconductor refrigeration device 12 close to the second material container 42 was a hot surface, and the side close to the heat dissipation The second side of the peltier device 12 of the sheet group 131 is a cold side. At this time, the first side of the semiconductor refrigeration device 12 transfers heat to the second material container 42 through the first heat vapor chamber 14 and the heat conduction sleeve 11, so as to realize the purpose of heating the second material container 42, and the second material container 42 The temperature rises to the temperature required by the auxiliary materials; at the same time, the heat in the environment can be transferred to the second side of the semiconductor refrigeration device 12 through the heat sink group 131 and the second soaking plate 15, and the second side of the semiconductor refrigeration device 12 is raised. Therefore, the temperature difference between the first side and the second side of the semiconductor refrigerator 12 can be reduced, that is, the temperature difference between the cold and hot surfaces of the semiconductor refrigerator 12 can be reduced, and the upper limit of heating of the semiconductor refrigerator 12 can be increased.

(2) Conversely, when the temperature of the second material container 42 was higher than the required temperature of the auxiliary material, the semiconductor refrigeration system was in a cooling state, and the first side of the semiconductor refrigeration device 12 close to the second material container 42 became a cold surface, The second side of the semiconductor refrigeration device 12 close to the heat sink 13 becomes the hot surface. At this time, the heat of the second material container 42 is transferred to the first side of the semiconductor refrigeration device 12 through the first heat conduction sleeve 11 and the first vapor chamber 14, that is, the first side of the semiconductor refrigeration device 12 is transferred from the second material container 42 Absorb heat to achieve the purpose of cooling the second material container 42, so that the temperature of the second material container 42 is reduced to the temperature required by the auxiliary material; at the same time, the second side of the semiconductor refrigeration device 12 passes the heat through the second vapor chamber 15 The heat is transferred to the heat sink group 131 and finally released to the environment under the action of the heat dissipation fan 132, reducing the temperature difference between the cold and hot surfaces of the semiconductor refrigeration device 12 and improving the cooling effect of the semiconductor refrigeration device 12.

The container temperature control system 1 of this embodiment has the characteristics of small size, fast response, and good control characteristics. Since a container temperature control system 1 is respectively provided at the first material container 41 and the second material container 42, the temperature control system of the bioprinter in this embodiment can control the temperature of the main material and the auxiliary material respectively to meet the requirements of the main material and the auxiliary material. Different temperature requirements enable the main and auxiliary materials to maintain better biological properties. In addition, due to the combined structure of semiconductor refrigeration system and vapor chamber, the heat transfer efficiency is higher, the heat transfer process is more uniform, and the control accuracy is higher. , can reach 0.01 degrees, and heating and cooling can be selected in two directions, which can adapt to the needs of various biological materials and different working environments, so that the same bioprinter has a wider selection of printing materials.

As shown in Figures 1-4, in this embodiment, the nozzle temperature control system 2 includes a nozzle heat conduction block 21, and the flow channel temperature control system 3 includes a flow channel heat conduction block 31, wherein the nozzle heat conduction block 21 is arranged on the first material container 41, and located on the outer periphery of the nozzle 5, the flow channel heat conduction block 31 is arranged below the second material container 42, and located on the outer periphery of the auxiliary material flow channel 421, the first side of the nozzle heat conduction block 21 is located at the first material container 41 The first vapor chamber 14 of the container temperature control system 1 is connected, the second side of the nozzle heat conduction block 21 is connected to the first side of the flow channel heat conduction block 31, and the second side of the flow channel heat conduction block 31 is connected to the second side of the flow channel heat conduction block 31. The first vapor chamber 14 of the container temperature control system 1 at the material container 42 is connected, so that the semiconductor refrigeration device 12 on the side of the first material container 41 can communicate with the nozzle 5 through the first vapor chamber 14 and the nozzle heat conduction block 21. Heat exchange realizes the temperature control of the nozzle 5, and the semiconductor refrigeration device 12 on the side of the second material container 42 can conduct heat exchange with the auxiliary material flow channel 421 through the first heat soaking plate 14 and the flow channel heat conduction block 31 to realize the temperature control of the nozzle 5. Temperature control of the auxiliary material channel 421. It can be seen that this embodiment can adapt the temperature of the nozzle 5 and the auxiliary material flow channel 421 to the requirements of the printing material, avoiding the printing material, especially the high-viscosity printing material, from clogging at the nozzle 5 and the auxiliary material flow channel 421, And it is beneficial to maintain the biological activity of the printed material.

As shown in FIG. 4 , in this embodiment, the auxiliary material flow channel 421 is directly arranged in the flow channel heat conduction block 31 , and the auxiliary material flows into the nozzle 5 through the auxiliary material flow channel after exiting from the second material container 42 . The auxiliary material flow channel 421 is directly arranged in the flow channel heat conduction block 31 , so that the flow path of the auxiliary material can be adjusted as required, and the auxiliary material can be guided to a desired position.

As shown in Figure 4, in this embodiment, a part of the auxiliary material flow channel 421 needs to pass through the nozzle heat conduction block 21 before entering the nozzle 5. A thermal insulation layer (not shown) is provided around the inner auxiliary material flow channel 421 , which can ensure that the temperature inside the auxiliary material flow channel 21 is not affected by the temperature of the nozzle heat conduction block 21 that it flows through.

The setting method of the temperature control system of the bioprinter of the present invention is not limited to the method shown in this embodiment, it can be set according to the specific structural relationship of the bioprinting material container 4, nozzle 5 and flow channel of the bioprinter, For example, if the bioprinter only includes one bioprinting material container 4, then the temperature control system of the bioprinter can only include one container temperature control system 1, if the bioprinter is also provided with a comparative If the main material flow channel is long, the flow channel temperature control system 3 can also be used to control the temperature of the main material flow channel, etc., and these setting methods are all within the protection scope of the present utility model.

The bioprinter provided by the utility model includes a bioprinting material container 4 and a bioprinter temperature control system of the utility model, and the thermal sleeve 11 of the container temperature control system 1 of the bioprinter temperature control system is arranged on the periphery of the bioprinting material container 4 .

The above descriptions are only exemplary embodiments of the present utility model, and are not intended to limit the present utility model. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present utility model shall be included in this utility model. within the scope of protection of utility models.

Claims (18)

1. a biometric print machine temperature control system, it is characterized in that, including runner temperature control system (3) and biometric print containers (4), described runner temperature control system (3) is for controlling the temperature of runner between outlet and the nozzle (5) of biometric print machine of the biometric print containers (4) of biometric print machine, so that the temperature required for the temperature of described runner and biometric print material is consistent.

2. biometric print machine temperature control system according to claim 1, it is characterized in that, described biometric print machine temperature control system includes container temperature control system (1), described container temperature control system (1) includes heat-exchange device, described heat-exchange device is for carrying out heat exchange with biometric print containers (4), temperature required for the biometric print material that temperature to control biometric print containers (4) contains with it is consistent, described biometric print machine temperature control system also includes the first soaking plate (14) being arranged between described biometric print containers (4) and described heat-exchange device, described first soaking plate (14) is used for the uniform heat transmission realizing between described heat-exchange device and described biometric print containers (4).

3. biometric print machine temperature control system according to claim 2, it is characterized in that, described heat-exchange device includes heat-exchanging part (12) and heat abstractor (13), described biometric print containers (4) can be heated and freeze by described heat-exchanging part (12), described first soaking plate (14) is arranged between the first side of described biometric print containers (4) and described heat-exchanging part (12), second side of described heat-exchanging part (12) is connected with described heat abstractor (13), described heat abstractor (13) is used for the heat transmission realizing between described heat-exchanging part (12) and environment.

4. biometric print machine temperature control system according to claim 3, it is characterized in that, described container temperature control system (1) also includes the second soaking plate (15), described second soaking plate (15) is arranged between the second side of described heat-exchanging part (12) and described heat abstractor (13), is used for the uniform heat transmission realizing between described heat-exchanging part (12) and described heat abstractor (13).

5. biometric print machine temperature control system according to claim 4, it is characterized in that, described heat abstractor (13) includes groups of fins (131) and radiator fan (132), described groups of fins (131) is connected with the second side of described heat-exchanging part (12), described radiator fan (132) is used for the heat transmission realizing between described groups of fins (131) and environment, described second soaking plate (15) is arranged between the second side of described heat-exchanging part (12) and described groups of fins (131), for realizing the uniform heat transmission between described heat-exchanging part (12) and described groups of fins (131).

6. biometric print machine temperature control system according to claim 5, it is characterised in that the air outlet of described radiator fan (132) deviates from the print platform of described biometric print machine and arranges.

7. biometric print machine temperature control system according to claim 5, it is characterized in that, described radiator fan (132) is speed-regulating fan, described container temperature control system (1) also includes exothermic temperature detection control apparatus, and described exothermic temperature detection control apparatus is used for detecting the temperature of described groups of fins (131) can according to the difference of the temperature of described groups of fins (131) and ambient temperature to control whether described radiator fan (132) is opened and regulate the rotating speed of described radiator fan (132).

8. biometric print machine temperature control system according to claim 2, it is characterized in that, described container temperature control system (1) also includes vessel temp detection control apparatus, and described vessel temp detection control apparatus is used for detecting the temperature of described biometric print containers (4) and feeding back to described heat-exchange device to form the closed loop control to described biometric print containers (4) temperature.

9. biometric print machine temperature control system according to claim 1, it is characterized in that, described biometric print machine temperature control system also includes nozzle temperature control system (2), described nozzle temperature control system (2) is for controlling the temperature of nozzle (5) of biometric print machine, so that the temperature required for the temperature of described nozzle (5) and described biometric print material is consistent.

10. biometric print machine temperature control system according to claim 9, it is characterized in that, described nozzle temperature control system (2) includes nozzle heat-conducting block (21), and described nozzle heat-conducting block (21) is arranged on the periphery of described nozzle (5).

11. biometric print machine temperature control system according to claim 1, it is characterized in that, described runner temperature control system includes runner heat-conducting block (31), the periphery of the runner that described runner heat-conducting block (31) is arranged between the outlet of biometric print containers (4) and nozzle (5).

12. biometric print machine temperature control system according to claim 2, it is characterized in that, described biometric print machine temperature control system includes two independent described container temperature control systems (1), one of them container temperature control system (1) is for carrying out temperature control to first containers (41) of described biometric print containers (4), and other in which container temperature control system (1) is for carrying out temperature control to second containers (42) of described biometric print containers (4).

13. biometric print machine temperature control system according to claim 3, it is characterised in that described heat-exchanging part (12) includes semiconductor chilling plate.

14. a biometric print machine, it is characterised in that include biometric print machine temperature control system as claimed in claim 1.

15. biometric print machine according to claim 14, it is characterized in that, described biometric print containers (4) includes the first containers (41) and the second containers (42), the outlet of the nozzle of described biometric print machine and one of described first containers (41) and described second containers (42) is by described flow passage, the nozzle of described biometric print machine is joined directly together with another the outlet in described first containers (41) and described second containers (42), is provided with runner heat-conducting block in described runner periphery.

16. biometric print machine according to claim 15, it is characterized in that, being provided with nozzle heat-conducting block (21) on the periphery of described nozzle, described runner sequentially passes through described runner heat-conducting block from described outlet and connects with described nozzle with described nozzle heat-conducting block.

17. biometric print machine according to claim 16, it is characterised in that be provided with thermal insulation layer on the periphery of the described runner in described nozzle heat-conducting block (21), for isolating the heat from described nozzle heat-conducting block (21).

18. biometric print machine according to claim 17, it is characterised in that: described thermal insulation layer is arranged between described runner and described nozzle heat-conducting block.