CN113171147A - Grafts suitable for treating vascular diseases - Google Patents
Grafts suitable for treating vascular diseases Download PDFInfo
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- CN113171147A CN113171147A CN202110372035.8A CN202110372035A CN113171147A CN 113171147 A CN113171147 A CN 113171147A CN 202110372035 A CN202110372035 A CN 202110372035A CN 113171147 A CN113171147 A CN 113171147A
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- stent
- graft
- blood vessel
- main body
- wall
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- 208000019553 vascular disease Diseases 0.000 title claims abstract description 10
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 55
- 239000000945 filler Substances 0.000 claims abstract description 34
- 230000000903 blocking effect Effects 0.000 claims abstract description 14
- 239000011248 coating agent Substances 0.000 claims abstract description 14
- 238000000576 coating method Methods 0.000 claims abstract description 14
- 230000001174 ascending effect Effects 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 6
- 238000002955 isolation Methods 0.000 abstract description 14
- 239000008280 blood Substances 0.000 abstract description 10
- 210000004369 blood Anatomy 0.000 abstract description 10
- 230000000694 effects Effects 0.000 description 7
- 210000000709 aorta Anatomy 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 239000007943 implant Substances 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 4
- 206010002329 Aneurysm Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000007474 aortic aneurysm Diseases 0.000 description 2
- 206010002895 aortic dissection Diseases 0.000 description 2
- 238000002224 dissection Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000011229 interlayer Substances 0.000 description 2
- 210000005240 left ventricle Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 208000002251 Dissecting Aneurysm Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
- A61B17/12118—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm for positioning in conjunction with a stent
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a graft suitable for treating vascular diseases, which comprises a stent main body and a blocking structure arranged along the circumference of the stent main body; wherein the blocking structure comprises: the coating body is connected with the film of the stent main body to form a cavity surrounding the stent main body; and a filler body contained within the lumen and configured to be expandable after the graft is released in a blood vessel to cause the occluding structure to protrude from the surface of the stent body and to occlude a gap between an outer wall of the graft and an inner wall of the blood vessel. The graft disclosed by the invention is provided with the blocking structure arranged along the circumference of the stent main body, and after the graft is released in a blood vessel, the blocking structure can protrude from the surface of the stent main body and block a gap between the outer wall of the graft and the inner wall of the blood vessel, so that the backflow and the internal leakage of blood are prevented, the effective isolation is realized, and the graft can play an effective treatment role in the blood vessel.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a graft suitable for treating vascular diseases.
Background
For common diseases of a cardiovascular system, aortic aneurysm shows local expansion of an artery, mechanical properties of a blood vessel wall surface are reduced, the aneurysm is easy to break after the disease condition is worsened, and the death rate is extremely high; aortic dissection is caused by pathological changes of aortic vascular tissues, intima rupture causes blood to flow into media and adventitia to form a false cavity, and the most serious result is dissection bleeding, the dissection process is painful, and the death rate is extremely high.
At present, the two diseases can be treated by implanting the covered stent, and blood and the wall of the blood vessel are separated by the covered stent, so that the blood flow is prevented from directly acting on the wall surface of the blood vessel. The ascending aortic dissection and the ascending aortic aneurysm are both characterized by abnormal shape of the ascending aorta and the valve annulus and are greatly expanded. In this case, how to effectively isolate the graft in the case of abnormal tissue expansion becomes a key factor in determining whether the graft can perform a therapeutic function.
Disclosure of Invention
In order to achieve the effective isolation, the embodiment of the invention provides a graft suitable for treating vascular diseases, and the gap between the outer wall of the graft and the inner wall of a blood vessel is blocked by the blocking structure arranged along the circumference of the stent main body, so that the effective isolation can be achieved under the condition of abnormal tissue expansion, and the treatment effect of the graft on the vascular diseases is guaranteed.
Embodiments of the present invention provide a graft suitable for treating vascular disease comprising a stent body and an occluding structure disposed circumferentially around the stent body; wherein the blocking structure comprises: the coating body is connected with the film of the stent main body to form a cavity surrounding the stent main body; and a filler body contained within the lumen and configured to be expandable after the graft is released in a blood vessel to cause the occluding structure to protrude from the surface of the stent body and to occlude a gap between an outer wall of the graft and an inner wall of the blood vessel.
According to the graft of the embodiment, the graft is provided with the blocking structure arranged along the circumference of the stent main body, and after the graft is released in a blood vessel, the blocking structure can protrude from the surface of the stent main body and block a gap between the outer wall of the graft and the inner wall of the blood vessel, so that the backflow and the internal leakage of blood are prevented, the effective isolation is realized, and the graft can play an effective treatment role in the blood vessel. Particularly, the coating body in the plugging structure is connected with the coating film of the main stent body and forms a cavity for accommodating the filling body, and after the graft is released in the blood vessel, the filling body can expand, so that the coating body protrudes from the surface of the main stent body to plug a gap between the outer wall of the graft and the inner wall of the blood vessel, and an effective isolation effect is realized.
In some embodiments of the invention, the filling body is made of a water-swellable material. Therefore, before the filling body is released in the blood vessel, the filling body can be pressed and held, the blood vessel is conveniently led in, and the plugging structure can be ensured to expand after being released in the blood vessel so as to plug the gap between the outer wall of the graft and the inner wall of the blood vessel, thereby realizing effective isolation effect.
In some embodiments of the invention, the filling body is configured as a plurality of spheroids. The spheroid is easily pressed and held, so the volume before release is small, and after release, the spheroid is easily extruded to the clearance under the effect of external force, until adjacent clearance is completely filled, other spheroids can enter the next clearance, thereby an intelligent filling mechanism can be formed, and effective isolation effect is realized.
In some embodiments of the invention, the filler comprises a fluff. The fluff comprises a porous structure like a sponge or a space support structure constructed from fabrics, polymers, etc. The fluffy material can be pressed and held before being released, and the covering body can be supported by the elasticity of the fluffy material after being released so as to block the gap between the outer wall of the graft and the inner wall of the blood vessel and realize effective isolation effect.
In some embodiments of the invention, the filler body comprises a plurality of self-expanding bare stents.
In some embodiments of the invention, the self-expanding bare stent comprises a cylindrical stent or a spherical stent.
In an alternative embodiment of the invention, a cylindrical stent is disposed within the lumen along a circumference of the stent body.
In some embodiments of the invention, the filling body comprises biological tissue. The biological tissue includes a biological scaffold that can direct the growth of cells.
In some embodiments of the invention, the cover is attached to the cover of the stent body by stitching.
In some embodiments of the invention, the stent body comprises an ascending aortic stent and a valvular stent, and a proximal end of the ascending aortic stent is connected to a distal end of the valvular stent; the plugging structure is arranged at or close to the proximal end of the ascending aortic stent, and the plugging structure is also arranged at or close to the proximal end of the valve stent.
According to the graft of the embodiment, the plugging structure is arranged at or near the connecting part of the ascending aorta stent and the valve stent, so that a interlayer or aneurysm can be isolated, and internal leakage can be prevented; and an occluding structure is arranged at or near the proximal end of the valve support, so that the valve support can seal the valve ring and prevent blood from flowing backwards/backwards into the left ventricle.
In conclusion, the graft adopting the embodiment of the invention can effectively isolate the abnormal tissue expansion condition, thereby ensuring the effective treatment of the graft on the vascular diseases.
Various aspects, features, advantages, etc. of embodiments of the invention are described in detail below with reference to the accompanying drawings. The above aspects, features, advantages, etc. of the present invention will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings.
Drawings
FIG. 1 is a schematic cross-sectional view of a graft according to an embodiment of the invention in a blood vessel;
fig. 2 is an enlarged view of the implant according to embodiment 1 of the present invention corresponding to part a in fig. 1, showing a spherical filler as an example of the filler body;
FIG. 3 is a cross-sectional view of the graft shown in FIG. 2 implanted in a blood vessel;
fig. 4 is an enlarged view of the graft according to example 2 of the present invention corresponding to part a in fig. 1, showing fluffs as an example of the filler;
FIG. 5 is a cross-sectional view of the graft shown in FIG. 4 implanted in a blood vessel;
fig. 6 is a schematic view of a cylindrical braided stent as a filler in a graft of example 3 of the present invention;
FIG. 7 is a cross-sectional view of the graft shown in FIG. 6 implanted in a blood vessel;
fig. 8 is a schematic view of a spherical braided stent as a filler in the graft of example 4 of the present invention;
fig. 9 is an enlarged view of the implant according to embodiment 4 of the present invention corresponding to portion a of fig. 1, showing a spherical braided stent as an example of the filler.
Detailed Description
To facilitate an understanding of the various aspects, features and advantages of the present inventive subject matter, reference is made to the following detailed description taken in conjunction with the accompanying drawings. It is to be understood that the following embodiments are illustrative only and not intended to limit the scope of the present invention, and that various combinations may be made without departing from the spirit of the invention.
Embodiments of the present invention provide a graft suitable for treating vascular disease comprising a stent body and an occluding structure disposed circumferentially around the stent body; wherein the blocking structure comprises: the coating body is connected with the film of the stent main body to form a cavity surrounding the stent main body; and a filler body contained within the lumen and configured to be expandable after the graft is released in a blood vessel to cause the occluding structure to protrude from the surface of the stent body and to occlude a gap between an outer wall of the graft and an inner wall of the blood vessel.
FIG. 1 is a schematic cross-sectional view of a graft according to an embodiment of the invention in a blood vessel.
As shown in fig. 1, the graft 100 includes a stent main body 1 and an occlusion structure 2 arranged along the circumference of the stent main body 1, and the occlusion structure 2 includes a covering body 21 and a filling body 22.
Referring to fig. 1, a stent body 1 includes an ascending aorta stent 11 and a valve stent 12. The upper part of the figure is far from the ventricle, the lower part is close to the ventricle, as shown in figure 1, the proximal end of the ascending aorta stent 11 is connected with the distal end of the valve stent 12, the proximal end of the ascending aorta stent 11 is provided with the blocking structure 2, and the proximal end close to the valve stent 12 is also provided with the blocking structure 2. By arranging the blocking structure at or near the joint of the ascending aorta stent and the valve stent, the interlayer or aneurysm can be isolated, and internal leakage can be prevented; and an occluding structure is arranged at or near the proximal end of the valve support, so that the valve support can seal the valve ring and prevent blood from flowing backwards/backwards into the left ventricle.
In alternative embodiments, the occluding structure may be positioned near the proximal end of the ascending aortic stent or at the proximal end of the valve stent.
In embodiments of the invention in which the filling body in the implant is made of a material that is capable of expanding after release, various embodiments of different filling bodies are given below as implants of the filling body in fig. 1.
[ example 1 ]
In example 1 of the present invention, the filling body in the graft is a spherical filling, fig. 2 is an enlarged view of the graft according to example 1 of the present invention corresponding to part a of fig. 1, and fig. 3 is a sectional view of the graft shown in fig. 2 implanted in a blood vessel.
Referring to fig. 2 and 3, the coating body 21 in the plugging structure arranged along the circumference of the stent main body 1 is connected with the coating film 10 of the stent main body to form a cavity 23 surrounding the stent main body, the spherical filler 221 is accommodated in the cavity 23, and after the graft is released in the blood vessel 3, the spherical filler 221 will expand in the cavity 23 between the coating film 10 of the stent main body 1 and the coating body 21 when encountering water (blood), so that the coating body 21 protrudes from the surface of the stent main body 1, and plugs the gap between the outer wall of the graft and the inner wall of the blood vessel 3, thereby realizing effective isolation.
In one embodiment, the cover 21 and the cover 10 of the stent body 1 may be joined by a suture method as shown in fig. 2.
In alternative embodiments, the spherical filler may be a hollow or solid sphere. The spherical filler is a substance which swells when meeting water (blood), the spherical filler is small in volume before being expanded and is easy to press, and after the spherical filler is released, the spherical filler meets the blood expansion and is extruded into the gap until the adjacent gap is completely filled, and other spherical fillers can enter the next gap, so that an intelligent filling mechanism can be formed, and an effective isolation effect is realized.
In an alternative embodiment, the spherical filler is made of a material that swells with water, for example, may be made of hydrogel.
[ example 2 ]
In example 2 of the present invention, the filler in the graft is a puff. Fig. 4 is an enlarged view of a graft according to example 2 of the present invention corresponding to a portion a of fig. 1, and fig. 5 is a sectional view of the graft shown in fig. 4 implanted in a blood vessel.
Referring to fig. 4 and 5, the cover 21 of the occluding structure arranged along the circumference of the stent body 1 is connected with the cover 10 of the stent body to form a cavity 23 surrounding the stent body, and the puffs 222 are accommodated in the cavity 23, and after the graft is released in the blood vessel 3, the puffs 222 are expanded in the cavity 23 between the cover 10 of the stent body 1 and the cover 21, so that the cover 21 protrudes from the surface of the stent body 1, and the gap between the outer wall of the graft and the inner wall of the blood vessel 3 is occluded. The fluffy structure can be pressed and held before the graft enters the blood vessel, and the graft is released in the blood vessel and then depends on the elastic supporting coating body of the graft so as to seal a gap between the outer wall of the graft and the inner wall of the blood vessel and realize effective isolation. In alternative embodiments, the fluff comprises a sponge-like porous structure or a space support structure constructed from fabrics, polymers, or the like.
[ example 3 ]
In example 3 of the present invention, the filler in the graft is a self-expanding stent, for example, a cylindrical braided stent, and fig. 6 shows an example of the cylindrical braided stent. Fig. 7 is a cross-sectional view of the graft shown in fig. 6 implanted in a blood vessel.
Referring to fig. 6 and 7, the cover 21 of the occlusion structure arranged along the circumference of the stent main body 1 is connected with the stent main body covering film 10 to form a cavity 23 surrounding the stent main body, the cylindrical braided stent 223 is arranged in the cavity 23 along the circumferential direction of the stent main body 1, when the graft is released in the blood vessel 3, the cylindrical braided stent 223 expands in the cavity 23 between the stent main body covering film 10 and the cover 21, the cover 21 protrudes from the surface of the stent main body 1, and the gap between the outer wall of the graft and the inner wall of the blood vessel 3 is occluded. The cylindrical woven stent can be compressed, can be pressed and held before the graft enters a blood vessel, and can be self-expanded after the graft is released in the blood vessel so as to seal a gap between the outer wall of the graft and the inner wall of the blood vessel and realize effective isolation.
In an alternative embodiment, the self-expanding stent comprises a self-expanding bare stent that is a laser-cut metal stent.
In some embodiments of the invention, the self-expanding stent has a diameter of about 2-8mm and a length of about 2-15 mm.
[ example 4 ]
In example 4 of the present invention, the self-expandable stent as the filler in the graft is a spherical braided stent, and fig. 8 shows an example of the spherical braided stent. Fig. 9 is an enlarged view of the implant according to embodiment 4 of the present invention corresponding to portion a of fig. 1, showing a spherical braided stent as an example of the filler.
Referring to fig. 8 and 9, the cover 21 of the occluding structure arranged along the circumference of the stent main body is connected with the covering membrane 10 of the stent main body to form a cavity 23 surrounding the stent main body, the spherical braided stent 224 is accommodated in the cavity 23, and after the graft is released in the blood vessel, the spherical braided stent 224 is expanded in the cavity 23 between the covering membrane 10 of the stent main body and the cover 21, the cover 21 protrudes from the surface of the stent main body, and the gap between the outer wall of the graft and the inner wall of the blood vessel is occluded. Wherein the spherical braided stent can be compressed, can be crimped before the graft enters the blood vessel, and can self-expand after the graft is released in the blood vessel to fill the gap between the outer wall of the graft and the inner wall of the blood vessel, thereby realizing effective isolation.
It will be appreciated by those skilled in the art that the graft of the present invention is not limited to the ascending aortic stent graft described above, but may be a stent graft for other blood vessels, and the location at which the occluding structure is disposed along the stent body is not limited to the embodiment shown in fig. 1, which may be adjusted according to the location of the vascular lesion. The filler in the graft is also not limited to the above examples, and the filler in the graft may also be a mixture of a plurality of fillers. In addition, the size, shape or dimension of the filler can be properly adjusted according to the characteristics of the gap between the outer wall of the graft and the inner wall of the blood vessel and the characteristics of the cavity formed by the coating body and the film of the stent main body.
With the graft according to the embodiments of the present invention, after being released in a blood vessel, the blocking structure can protrude from the surface of the stent main body, and the filler expands to block the gap between the outer wall of the graft and the inner wall of the blood vessel, thereby preventing the backflow and internal leakage of blood, and achieving effective isolation, thereby ensuring that the graft can play an effective therapeutic role in the blood vessel.
It should be understood by those skilled in the art that the foregoing is only illustrative of the present invention, and is not intended to limit the scope of the invention.
Claims (10)
1. A graft adapted for treatment of vascular disease, characterised in that the graft comprises a stent body and an occluding structure disposed circumferentially around the stent body;
wherein the blocking structure comprises:
the coating body is connected with the film of the stent main body to form a cavity surrounding the stent main body; and
a filler body contained within the lumen and configured to be expandable after the graft is released in a blood vessel to cause the occluding structure to protrude from the surface of the stent body and to occlude a gap between an outer wall of the graft and an inner wall of the blood vessel.
2. The graft in accordance with claim 1, wherein said filling body is made of a water-swellable material.
3. The graft in accordance with claim 2, wherein said filler is configured as a plurality of spheroids.
4. The graft of claim 1, wherein said filler comprises a puff.
5. The graft of claim 1, wherein said filler comprises a plurality of self-expanding bare stents.
6. The graft of claim 5, wherein said self-expanding bare stent comprises a cylindrical stent or a spherical stent.
7. The graft of claim 6, wherein said cylindrical stent is disposed circumferentially of said stent body within said lumen.
8. The graft of claim 1, wherein said filler comprises biological tissue.
9. The graft in accordance with claim 1, wherein said cover is joined to said stent body cover by stitching.
10. The graft of claim 1, wherein the stent body comprises an ascending aortic stent and a valvular stent, and a proximal end of the ascending aortic stent is connected to a distal end of the valvular stent;
the plugging structure is arranged at or close to the proximal end of the ascending aortic stent, and the plugging structure is also arranged at or close to the proximal end of the valve stent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110372035.8A CN113171147A (en) | 2021-04-07 | 2021-04-07 | Grafts suitable for treating vascular diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110372035.8A CN113171147A (en) | 2021-04-07 | 2021-04-07 | Grafts suitable for treating vascular diseases |
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| Publication Number | Publication Date |
|---|---|
| CN113171147A true CN113171147A (en) | 2021-07-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110372035.8A Pending CN113171147A (en) | 2021-04-07 | 2021-04-07 | Grafts suitable for treating vascular diseases |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102125475A (en) * | 2011-01-24 | 2011-07-20 | 中国人民解放军第二军医大学 | Combined ascending aortic intracavitary isolation implant |
| US20130331929A1 (en) * | 2011-09-09 | 2013-12-12 | Endoluminal Sciences Pty Ltd. | Means for Controlled Sealing of Endovascular Devices |
| CN204072390U (en) * | 2014-08-29 | 2015-01-07 | 张学民 | Prevent the Stent-graft of internal hemorrhage due to trauma |
| CN104887348A (en) * | 2014-12-19 | 2015-09-09 | 中国人民解放军第二军医大学 | I-type internal leakage prevention support transplanting system with sponge structure attached |
| CN107072777A (en) * | 2014-11-03 | 2017-08-18 | 美敦力瓦斯科尔勒公司 | Apparatus and method for treating aneurysm and other angiosises |
| US20190117387A1 (en) * | 2017-10-24 | 2019-04-25 | St. Jude Medical, Cardiology Division, Inc. | Self-expandable filler for mitigating paravalvular leak |
| US20200383770A1 (en) * | 2019-06-04 | 2020-12-10 | Bentley Innomed Gmbh | Stent graft with sealing element |
-
2021
- 2021-04-07 CN CN202110372035.8A patent/CN113171147A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102125475A (en) * | 2011-01-24 | 2011-07-20 | 中国人民解放军第二军医大学 | Combined ascending aortic intracavitary isolation implant |
| US20130331929A1 (en) * | 2011-09-09 | 2013-12-12 | Endoluminal Sciences Pty Ltd. | Means for Controlled Sealing of Endovascular Devices |
| CN204072390U (en) * | 2014-08-29 | 2015-01-07 | 张学民 | Prevent the Stent-graft of internal hemorrhage due to trauma |
| CN107072777A (en) * | 2014-11-03 | 2017-08-18 | 美敦力瓦斯科尔勒公司 | Apparatus and method for treating aneurysm and other angiosises |
| CN104887348A (en) * | 2014-12-19 | 2015-09-09 | 中国人民解放军第二军医大学 | I-type internal leakage prevention support transplanting system with sponge structure attached |
| US20190117387A1 (en) * | 2017-10-24 | 2019-04-25 | St. Jude Medical, Cardiology Division, Inc. | Self-expandable filler for mitigating paravalvular leak |
| US20200383770A1 (en) * | 2019-06-04 | 2020-12-10 | Bentley Innomed Gmbh | Stent graft with sealing element |
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