CN112569457B - Continuous administration cyst tube system - Google Patents

Abstract

The invention relates to a continuous drug delivery sac system, which includes a sac-shaped blind end, a flow-limiting channel and a drainage tube. The sac-shaped blind end is made of elastic and expandable material and can be buried under the skin; the flow-limiting channel is sealed and connected to the sac-shaped blind end. Between the blind end and the drainage tube; the sac-shaped blind end is used to store fluid drugs and continuously perfuse fluid drugs to the treatment target through the flow-limiting channel and the drainage tube; the flow-limiting channel is used to limit the flow of fluid drugs out of the sac-shaped blind end. The flow rate and flow rate are such that the fluid medicine injected into the sac-shaped blind end is temporarily retained in the sac-shaped blind end, and then the sac-shaped blind end is expanded, thereby maintaining the continuous flow of the fluid medicine from the sac-shaped blind end to the open end of the drainage tube. perfusion.

Description

A continuous drug delivery capsule system

Technical field

The invention relates to the technical field of medical devices, and in particular to a continuous drug delivery capsule system.

Background technique

At present, the traditional way of administering chemotherapy drugs is mainly intravenous injection. This method cannot accurately kill tumors, so it has shortcomings such as low efficiency and high side effects. Local administration is a better improved solution to solve the above problems, including: one-time local injection of drugs, multiple punctures for local administration, etc., local injection of drugs through drainage tubes, etc. However, the above local administration methods have their own shortcomings, which limit their clinical application.

The disadvantages of various local drug delivery methods include: due to the limited space in the body, the total dose of one-time local drug injection is low and the action time is short; multiple puncture local drug administration requires CT assistance and a higher technical level, and the risk is relatively high It is large and difficult to promote; local injection through the drainage tube can easily cause bacteria outside the body to enter the body through the outer opening of the drainage tube, posing a great risk of deep infection. Therefore, it is of great clinical significance to develop new local drug delivery devices to avoid the above shortcomings.

Contents of the invention

The present invention aims to provide a new type of continuous drug delivery capsule system to solve the problems of small drug loading, short action time, high risk of puncture operation, easy to cause deep infection and other problems faced by the local drug delivery scheme in the existing technology.

The purpose of the present invention is to solve the deficiencies of the prior art and provide a new type of continuous drug delivery sac system, which includes a sac-shaped blind end, a flow-limiting channel and a drainage tube. The sac-shaped blind end is made of elastic and expandable material. It is made and can be buried under the skin; the flow-limiting channel is sealed and connected between the sac-like blind end and the drainage tube; the sac-like blind end is used to store fluid medicine and deliver it to the treatment target through the flow-limiting channel and the drainage tube. The fluid medicine is continuously perfused; the flow-limiting channel is used to limit the flow rate and flow rate of the fluid medicine flowing out from the sac-shaped blind end, so that the fluid medicine injected into the sac-shaped blind end is temporarily retained in the sac. into the blind end of the sac, thereby inflating the blind end of the sac to maintain continuous perfusion of fluid medicine from the blind end of the sac to the open end of the drainage tube.

The therapeutic targets include locations around tumors or infection lesions in the human body.

The open end of the drainage tube is implanted into a therapeutic target deep in the human body.

After the cystic blind end is buried under the skin, drugs can be injected into the cystic blind end buried under the skin through simple subcutaneous, intramuscular or intravenous injection techniques.

Preferably, the cystic blind end allows the use of ordinary intramuscular injection needles, hypodermic injection needles or intravenous infusion needles to inject drugs into the cystic blind end buried under the skin.

There are one or more bladder-shaped blind ends.

There are one or more said open ends.

The sac-shaped blind end, flow-limiting channel and drainage tube are made of elastic silicone.

The cystic blind end can store 10ml to 400ml of medicine.

The flow-limiting channel allows the restricted flow rate of the fluid medicine flowing out from the sac-shaped blind end to be 0.5 ml/day to 10 ml/day, and the average administration period is 1 week to 1 year.

beneficial effects

Compared with the prior art, the beneficial effects of the present invention are:

The continuous drug administration capsule system of the present invention makes one end of the traditional silicone drainage tube into an enlarged capsule-shaped blind end, which is used to be buried under the skin to store drugs and receive in vitro injection. During the application process, it is buried in the The subcutaneous blind end of the capsule can accommodate more drugs, thereby solving the problem of small drug loading faced by one-time local injection of drugs; because the continuous drug delivery capsule system of the present invention can be used for repeated administration, and The flow-limiting channel can maintain continuous perfusion of drugs and avoid the problem of short action time faced by local injection of one-time drugs; when using the continuous drug delivery capsule system of the present invention, the puncture operation for local drug administration and Conventional subcutaneous, intramuscular or intravenous injection operations are similar and do not require CT assistance, thus avoiding the problems of high difficulty and high risk of puncture operations faced by multiple punctures for local administration; the capsule-shaped continuous drug delivery sac system of the present invention The blind end is buried under the skin and has no external part, which reduces the risk of external bacteria entering the body through the external opening of the drainage tube and causing deep infection.

Description of the drawings

The drawings are used to provide a further understanding of the technical solution of the present invention, and constitute a part of the description. They are used to explain the technical solution of the present invention together with the specific embodiments of the present application, and do not constitute a limitation of the technical solution of the present invention.

Figure 1 is a schematic diagram of the overall structure of the continuous drug delivery capsule system of the present invention.

Detailed ways

The invention is described in more detail below to facilitate understanding of the invention.

As shown in Figure 1, the continuous drug delivery bladder system of the present invention includes a bladder-shaped blind end 1, a flow-limiting channel 2 and a drainage tube 3. The bladder-shaped blind end is made of elastic and expandable material and can be buried. subcutaneously; the flow-limiting channel 2 is sealingly connected between the sac-like blind end 1 and the drainage tube 3; the sac-like blind end is used to store fluid medicine and deliver it to the treatment target through the flow-restricting channel 2 and the drainage tube 3 The fluid medicine is continuously perfused at one point; the flow-limiting channel 2 is used to limit the flow rate and flow rate of the fluid medicine flowing out from the sac-shaped blind end, so that the fluid medicine injected into the sac-shaped blind end temporarily remains. In the sac-like blind end, the sac-like blind end is then expanded to maintain continuous perfusion of fluid medicine from the sac-shaped blind end to the open end 4 of the drainage tube.

The therapeutic targets include locations around tumors or infection lesions in the human body.

The open end of the drainage tube is implanted into a therapeutic target deep in the human body.

After the cystic blind end is buried under the skin, drugs can be injected into the cystic blind end buried under the skin through simple subcutaneous, intramuscular or intravenous injection techniques.

Preferably, the cystic blind end allows the use of ordinary intramuscular injection needles, hypodermic injection needles or intravenous infusion needles to inject drugs into the cystic blind end buried under the skin.

It is further preferred that one or more sac-like blind ends are provided, and one or more open ends are also provided, to achieve drug loading and delivery of one or more drugs.

The sac-shaped blind end, flow-limiting channel and drainage tube are made of elastic silicone.

The continuous drug delivery capsule system of the present invention is improved on the basis of traditional silicone drainage tubes. Only the internal body part of the traditional drainage tube is retained, and the shallow end of the drainage tube is made into an expandable bladder shape with elastic silicone. Blind end, there is a narrow flow-limiting channel between the sac-like blind end and the drainage tube, which can only allow liquid to flow slowly (the sac-like blind end stores about 10-400ml of medicine, and the flow-limiting channel limits the flow rate to 0.5 -10ml/day, the average administration period is about 1 week to 1 year), so that the drug injected into the expanded blind end is temporarily retained, and then the cystic blind end is expanded to maintain continuous perfusion of the drug from the blind end to the open end. The user can implant the open end of the present invention into a deep treatment target (such as around a tumor or an infected lesion) according to the traditional drainage tube implantation method, and then bury the cystic blind end of the present invention under the skin. After surgery, you only need to use ordinary intramuscular injection needles, hypodermic injection needles or intravenous infusion needles, and use simple subcutaneous, intramuscular or intravenous injection techniques to inject drugs into the cystic blind end buried under the skin; inject drugs into the cystic blind end. Drugs can enter deep treatment targets through the drainage tube to achieve precise treatment effects.

The materials of the sac-shaped blind end, the flow-limiting channel and the drainage tube in the present invention are not limited to silicone materials, and other materials that can be used for human body implantation can be used as substitute materials for silicone.

The preferred embodiments of the present invention have been described above, but they are not intended to limit the present invention. Those skilled in the art may make modifications and changes to the embodiments disclosed herein without departing from the scope and spirit of the invention.

Claims (1)

1. A continuous drug delivery capsule system, characterized in that the continuous drug delivery capsule system is improved on the basis of traditional silicone drainage tubes, retaining only the body part of the traditional drainage tube, and converting the drainage tube into One end of the shallow part is made into an expandable sac-shaped blind end, and a narrow flow-limiting channel is left between the sac-shaped blind end and the drainage tube, so that the medicine injected into the expanded blind end can be temporarily retained, and then the sac-shaped blind end can be expanded to maintain the function. Continuous perfusion of medicine from the blind end to the open end; a natural transitional connection between the bladder-shaped blind end and the flow-restricting channel without any connecting parts; The continuous drug delivery sac system includes a sac-shaped blind end, a flow-limiting channel and a drainage tube. The sac-shaped blind end is made of elastic and expandable material and can be buried under the skin; the flow-limiting channel is sealed and connected. Between the cystic blind end and the drainage tube; the cystic blind end is used to store fluid medicine and continuously perfuse the fluid medicine to the treatment target through the flow-limiting channel and the drainage tube; the flow-limiting channel is used for The flow rate and flow rate of the fluid medicine flowing out from the sac-shaped blind end are limited, so that the fluid medicament injected into the sac-shaped blind end is temporarily retained in the sac-shaped blind end, and then the sac-shaped blind end is expanded, thereby maintaining Continuous perfusion of fluid medicine from the blind end of the sac to the open end of the drainage tube; The sac-shaped blind end, flow-limiting channel and drainage tube are made of elastic silicone; The cystic blind end can store 10ml to 400ml of medicine; The flow-limiting channel allows the restricted flow rate of the fluid medicine flowing out from the sac-shaped blind end to be 0.5 ml/day to 10 ml/day, and the average dosing period is 1 week to 1 year; One or more bladder-shaped blind ends are provided; There are one or more said open ends; The treatment targets include locations around tumors or infection lesions in the human body; The open end of the drainage tube is implanted at a therapeutic target deep in the human body; After the cystic blind end is buried under the skin, drugs can be injected into the cystic blind end buried under the skin through simple subcutaneous, intramuscular or intravenous injection techniques; The described cystic blind end allows the use of ordinary intramuscular injection needles, hypodermic injection needles or intravenous infusion needles to inject drugs into the cystic blind end buried under the skin. The user can implant the open end into the deep treatment target according to the traditional drainage tube implantation method, and then bury the cystic blind end under the skin; after surgery, only use an ordinary intramuscular injection needle , hypodermic injection needle or intravenous infusion needle, using simple subcutaneous, intramuscular or intravenous injection techniques, can inject drugs into the cystic blind end buried under the skin; the drugs injected into the cystic blind end enter the deep treatment target through the drainage tube, The effect of precise treatment is achieved; the sac-shaped blind end of the continuous drug delivery sac system is buried under the skin without an external part, which reduces the risk of external bacteria entering the body through the outer opening of the drainage tube and causing deep infection.