CN112409777A - Medical antibacterial breathable TPU film and preparation method thereof - Google Patents
Medical antibacterial breathable TPU film and preparation method thereof Download PDFInfo
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- CN112409777A CN112409777A CN202011240189.3A CN202011240189A CN112409777A CN 112409777 A CN112409777 A CN 112409777A CN 202011240189 A CN202011240189 A CN 202011240189A CN 112409777 A CN112409777 A CN 112409777A
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 38
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 32
- 239000002245 particle Substances 0.000 claims abstract description 27
- 239000005543 nano-size silicon particle Substances 0.000 claims abstract description 26
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 26
- 230000002745 absorbent Effects 0.000 claims abstract description 23
- 239000002250 absorbent Substances 0.000 claims abstract description 23
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920000153 Povidone-iodine Polymers 0.000 claims abstract description 19
- 229960001621 povidone-iodine Drugs 0.000 claims abstract description 19
- 238000001035 drying Methods 0.000 claims abstract description 17
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 16
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 239000004594 Masterbatch (MB) Substances 0.000 claims abstract description 14
- 229920001661 Chitosan Polymers 0.000 claims abstract description 13
- 239000000835 fiber Substances 0.000 claims abstract description 13
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 8
- 229920002545 silicone oil Polymers 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000000377 silicon dioxide Substances 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 229920000728 polyester Polymers 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 238000001125 extrusion Methods 0.000 claims description 3
- 238000005453 pelletization Methods 0.000 claims description 3
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 2
- 238000005266 casting Methods 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- JZZIHCLFHIXETF-UHFFFAOYSA-N dimethylsilicon Chemical compound C[Si]C JZZIHCLFHIXETF-UHFFFAOYSA-N 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 229920000570 polyether Polymers 0.000 claims description 2
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000035699 permeability Effects 0.000 abstract description 11
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 5
- 238000000576 coating method Methods 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 3
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 68
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 68
- 206010052428 Wound Diseases 0.000 description 8
- 208000027418 Wounds and injury Diseases 0.000 description 8
- 239000004800 polyvinyl chloride Substances 0.000 description 7
- 229920000915 polyvinyl chloride Polymers 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920006264 polyurethane film Polymers 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 239000012783 reinforcing fiber Substances 0.000 description 2
- 239000012763 reinforcing filler Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000010345 tape casting Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2375/04—Polyurethanes
- C08J2375/06—Polyurethanes from polyesters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
- C08J2405/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2439/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Derivatives of such polymers
- C08J2439/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08J2439/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2471/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
- C08J2471/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2483/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
- C08J2483/04—Polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/011—Nanostructured additives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/34—Silicon-containing compounds
- C08K3/36—Silica
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K7/00—Use of ingredients characterised by shape
- C08K7/02—Fibres or whiskers
- C08K7/04—Fibres or whiskers inorganic
- C08K7/08—Oxygen-containing compounds
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses a medical antibacterial breathable TPU film and a preparation method thereof, wherein the medical antibacterial breathable TPU film comprises the following components in parts by weight: 100 parts of TPU particles, 6-8 parts of dimethyl silicone oil, 15-20 parts of a water absorbent, 5-8 parts of nano silicon dioxide, 5-10 parts of calcium carbonate whiskers, 10-15 parts of chitosan fibers and 5-10 parts of povidone iodine; the preparation method comprises the following steps: preparing povidone iodine/TPU master batch; preparing a water absorbent, nano silicon dioxide and TPU mixed master batch; drying and mixing the materials; and (4) film forming. The TPU film prepared by the invention has excellent air permeability, water absorbability and bacteriostasis rate, and has a continuous disinfection effect; the film has excellent tensile strength under the condition of lower film thickness, ensures that the film cannot be broken or damaged in the using and coating processes, and overcomes the defect that the thickness and the mechanical strength of the traditional medical TPU film cannot be combined.
Description
Technical Field
The invention relates to the field of films, in particular to a medical antibacterial breathable TPU film and a preparation method thereof.
Background
The traditional PE and PVC films have the advantages of water resistance and liquid seepage resistance, and are very popular in medical protection of wound dressings, surgical operations and the like. However, because the PE and PVC films have the characteristic of poor air permeability, sweat generated by metabolism of a human body cannot be discharged in time, so that discomfort such as heat, cold and humidity and the like occur in the coated area, and the healing of wounds is also influenced. Therefore, there is a strong need for a new medical film to replace such products.
TPU (Thermoplastic polyurethane) is a novel organic polymer synthetic material, has excellent performances, and can replace rubber and PVC (polyvinyl chloride) which is a soft polyvinyl chloride material. The TPU has excellent physical properties such as abrasion resistance and resilience better than those of common polyurethane PU and PVC, has better aging resistance than rubber, is an ideal material for replacing PVC and PU, and is internationally called as a novel polymer material.
In recent years, polyurethane films have been increasingly used in the field of medical films because of their excellent properties. However, the existing medical polyurethane film is thick, cannot meet the requirements of excellent air permeability and moisture permeability, is easy to cause foreign body sensation and discomfort after being applied and affects the effective healing of wounds; or the film is thin and has insufficient strength, so that the film is easy to damage in the using process and the use is influenced.
Disclosure of Invention
The invention mainly solves the technical problem of providing a medical antibacterial breathable TPU film and a preparation method thereof, and can solve the problems of the existing medical film.
In order to solve the technical problems, the invention adopts a technical scheme that: the medical antibacterial breathable TPU film comprises the following components in parts by weight:
100 parts of TPU particles, 6-8 parts of dimethyl silicone oil, 15-20 parts of a water absorbent, 5-8 parts of nano silicon dioxide, 5-10 parts of calcium carbonate whiskers, 10-15 parts of chitosan fibers and 5-10 parts of povidone iodine.
In a preferred embodiment of the present invention, the water absorbent is a mixture of polyethylene glycol and polyvinylpyrrolidone in a mass ratio of 1:2 to 1: 3.
In a preferred embodiment of the invention, the TPU particles are polyester TPU particles and/or polyether TPU particles.
In a preferred embodiment of the invention, the nano-silica is fumed nano-silica, and the specific surface area of the nano-silica is 180m2/g。
In order to solve the technical problem, the invention adopts another technical scheme that: the preparation method of the medical antibacterial breathable TPU film comprises the following steps:
(1) preparing povidone iodine/TPU master batch: mixing the formula amount of the povidone iodine with a part of TPU particles, and then extruding and pelletizing the mixture by using a double-screw extruder;
(2) preparing a water absorbent, nano silicon dioxide and TPU mixed master batch: mixing the water absorbent, the nano silicon dioxide and a part of TPU particles according to the formula ratio, and then extruding and granulating by using a double-screw extruder;
(3) drying and mixing the materials: drying the TPU particles with the rest formula amount, the povidone iodine/TPU master batch prepared in the step (1), the water absorbent prepared in the step (2), the mixed master batch of the nano silicon dioxide and the TPU, and the dimethyl silicon oil, the calcium carbonate crystal whiskers and the chitosan fibers with the formula amount to remove moisture, and then uniformly mixing all the materials;
(4) film forming: and (3) conveying the mixed material in the step (2) into a casting machine, and extruding to form a film.
In a preferred embodiment of the present invention, the method for drying and removing water comprises: firstly drying the mixture by hot air at 80-85 ℃ for 1-1.5 h, and then dehumidifying and drying the mixture at 95-100 ℃ for 2-3 h.
In a preferred embodiment of the present invention, the process conditions of the extrusion film forming are as follows: the temperature of the charging barrel is 155-165 ℃; the temperature of the filter screen is 175-180 ℃; the temperature of the elbow is 178-185 ℃; the connection temperature is 180-190 ℃; the temperature of the die head is 195-200 ℃.
In a preferred embodiment of the present invention, the total water content of the dried and dewatered material is less than 0.01%.
The invention has the beneficial effects that: according to the medical antibacterial breathable TPU film and the preparation method thereof, the prepared TPU film has excellent air permeability, water absorbability and bacteriostasis rate and has a continuous disinfection effect by selecting and designing formula components and a forming method of firstly preparing TPU master batches, drying and dehydrating the TPU master batches and then blending the TPU master batches into a film; the film has excellent tensile strength under the condition of lower film thickness, ensures that the film cannot be broken or damaged in the using and coating processes, and overcomes the defect that the thickness and the mechanical strength of the traditional medical TPU film cannot be combined.
Detailed Description
The following detailed description of the preferred embodiments of the present invention is provided to enable those skilled in the art to more readily understand the advantages and features of the present invention, and to clearly and unequivocally define the scope of the present invention.
The embodiment of the invention comprises the following steps:
example 1
The invention discloses a medical antibacterial breathable TPU film which comprises the following components in parts by weight:
100 parts of TPU particles, wherein the TPU particles are polyester TPU particles;
6 parts of dimethyl silicone oil, wherein the dimethyl silicone oil can improve the processing performance of TPU particles and promote the dispersion uniformity of nano silicon dioxide, calcium carbonate whiskers, chitosan fibers and the like in TPU, so that the performance of the formed TPU film is improved;
15 parts of water absorbent, wherein the water absorbent is a mixture of polyethylene glycol and polyvinylpyrrolidone in a mass ratio of 1: 2; the water absorbent can absorb water vapor generated by metabolism of a human body or wound seepage in time, so that the surface of the wrapped skin (such as a wound) is kept dry and clean, and the wound healing speed is improved;
5 parts of nano silicon dioxide, wherein the nano silicon dioxide is gas-phase nano silicon dioxide, and the specific surface area of the nano silicon dioxide is 180m2Per g, by addition of nanosilicaThe mechanical strength of the TPU film can be effectively improved, and the film is prevented from being damaged in use due to poor strength;
5 parts of calcium carbonate whiskers, wherein the calcium carbonate whiskers are used as reinforcing fibers and play a role of reinforcing the structural strength of the TPU film together with the nano silicon dioxide, and particularly the tearing strength of the TPU film is improved to be excellent; the calcium carbonate whiskers are uniformly distributed in the TPU film in a fibrous shape, have a moisture-conducting effect, and can accelerate the absorption and diffusion of water and gas under the combined action of the calcium carbonate whiskers and the water absorbent, so that the air permeability of the TPU film is further improved.
10 parts of chitosan fiber, wherein the chitosan fiber has double effects of antibiosis and structure enhancement;
5 parts of povidone iodine and povidone iodine, wherein the povidone iodine is a loose compound formed by combining element iodine and a polymer carrier, has the effects of resisting bacteria and diminishing inflammation, is added into the mixture to prepare an antibacterial TPU film, has the effect of continuous disinfection by slowly releasing iodine, can reduce the re-colonization rate (CFU) of skin such as staphylococcus aureus, and is particularly suitable for operation easy to infect.
The preparation method of the medical antibacterial breathable TPU film comprises the following steps:
(1) preparing povidone iodine/TPU master batch: mixing 5 parts of povidone iodine and 20 parts of TPU particles, and then extruding and pelletizing the mixture by using a double-screw extruder;
(2) preparing a water absorbent, nano silicon dioxide and TPU mixed master batch: mixing 15 parts of polyethylene glycol and polyvinylpyrrolidone mixed according to the mass ratio of 1:2, 5 parts of nano silicon dioxide and 50 parts of TPU particles, and then extruding and granulating by using a double-screw extruder;
(3) drying and mixing the materials: drying 30 parts of TPU particles, the povidone iodine/TPU master batch prepared in the step (1), the water absorbent prepared in the step (2), the nano silicon dioxide and TPU mixed master batch, 6 parts of dimethyl silicone oil, 5 parts of calcium carbonate whiskers and 10 parts of chitosan fibers by hot air at 80-85 ℃ for 1h, and then dehumidifying and drying at 95-100 ℃ for 3h to remove moisture, so that the total moisture content of the dried and dehydrated materials is less than 0.01%, and then uniformly mixing the materials;
(4) film forming: conveying the mixed material in the step (2) into a tape casting machine, and extruding to form a film; the process conditions of the extrusion film forming are as follows: the temperature of the charging barrel is 160 ℃; the temperature of the filter screen is 175 ℃; the temperature of the elbow is 178 ℃; the connection temperature is 180 ℃; the die temperature was 195 ℃.
Example 2
The invention discloses a medical antibacterial breathable TPU film which comprises the following components in parts by weight:
100 parts of TPU particles, wherein the TPU particles are polyester TPU particles;
6 parts of dimethyl silicone oil, wherein the dimethyl silicone oil can improve the processing performance of TPU particles and promote the dispersion uniformity of nano silicon dioxide, calcium carbonate whiskers, chitosan fibers and the like in TPU, so that the performance of the formed TPU film is improved;
15 parts of water absorbent, wherein the water absorbent is a mixture of polyethylene glycol and polyvinylpyrrolidone in a mass ratio of 1: 3; the water absorbent can absorb water vapor generated by metabolism of a human body or wound seepage in time, so that the surface of the wrapped skin (such as a wound) is kept dry and clean, and the wound healing speed is improved;
8 parts of nano silicon dioxide, wherein the nano silicon dioxide is gas-phase nano silicon dioxide, and the specific surface area of the nano silicon dioxide is 180m2The mechanical strength of the TPU film can be effectively improved by adding the nano silicon dioxide, and the film is prevented from being damaged in use due to poor strength;
10 parts of calcium carbonate whiskers, wherein the calcium carbonate whiskers are used as reinforcing fibers and play a role of reinforcing the structural strength of the TPU film together with the nano silicon dioxide, and particularly the tearing strength of the TPU film is improved to be excellent; the calcium carbonate whiskers are uniformly distributed in the TPU film in a fibrous shape, have a moisture-conducting effect, and can accelerate the absorption and diffusion of water and gas under the combined action of the calcium carbonate whiskers and the water absorbent, so that the air permeability of the TPU film is further improved.
15 parts of chitosan fiber, wherein the chitosan fiber has double effects of antibiosis and structure enhancement;
the povidone iodine 10 parts and the povidone iodine are loose compounds formed by combining element iodine and a polymer carrier, have the effects of resisting bacteria and diminishing inflammation, are added into the mixture to prepare an antibacterial TPU film, have the effect of continuous disinfection by slowly releasing iodine, can reduce the re-colonization rate (CFU) of skin such as staphylococcus aureus, and are particularly suitable for operation easy to infect.
The preparation method is the same as example 1.
The TPU films prepared in examples 1 and 2 were tested for their properties as follows:
(1) the permeability test was performed as specified in appendix C of YY/T0148-2006, the Water vapor permeability test method.
(2) Water absorption test A test was carried out according to the "Water absorption test method" in YY/T0471.1-2004, to obtain the average amount of liquid absorbed (g/100 cm) in 30 minutes by a dressing having a film applied to the wound surface2)。
(3) Bacteriostasis test the bacteriostasis in the semi-moist state was tested according to the bacteriostasis protocol in YY/T0471.5-2004.
(4) The mechanical property test of the film is carried out on a universal tester according to the national standard GB 13022-91.
The results of the tests carried out in the above-described manner are shown in the table below.
The medical antibacterial breathable TPU film developed by the invention has the following advantages:
1. the TPU film is endowed with excellent air permeability and water absorption through the use of the water absorbent, the fibrous reinforcing filler and the fibrous bacteriostatic additive;
2. by compounding the chitosan fiber and the povidone iodine, the TPU film has excellent bacteriostasis rate and continuous disinfection effect;
3. by compounding and using the fibrous and nano-structured reinforcing filler, the structural strength of the film is effectively improved, particularly the excellent tensile strength is realized, the film is ensured not to be broken or damaged in the using and coating processes under the condition of lower film thickness, and the using requirement is met;
4. the preparation process is novel, and the compatibility of partial materials and TPU particles is ensured and the processing performance is ensured on the one hand by a forming method of preparing TPU master batches, drying and dehydrating the TPU master batches, and then blending the TPU master batches into a film; on the other hand, the prepared film has excellent antibacterial property, air permeability and mechanical property by fully drying and removing the influence of moisture, and the defect that the thickness and the mechanical strength of the traditional medical TPU film cannot be combined is overcome.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (8)
1. The medical antibacterial breathable TPU film is characterized by comprising the following components in parts by weight:
100 parts of TPU particles, 6-8 parts of dimethyl silicone oil, 15-20 parts of a water absorbent, 5-8 parts of nano silicon dioxide, 5-10 parts of calcium carbonate whiskers, 10-15 parts of chitosan fibers and 5-10 parts of povidone iodine.
2. The medical antibacterial breathable TPU film as claimed in claim 1, wherein the water absorbent is a mixture of polyethylene glycol and polyvinylpyrrolidone in a mass ratio of 1:2 to 1: 3.
3. The medical antibacterial breathable TPU film of claim 1, wherein the TPU particles are polyester TPU particles and/or polyether TPU particles.
4. The method of claim 1The medical antibacterial breathable TPU film is characterized in that the nano-silica is gas-phase nano-silica, and the specific surface area of the nano-silica is 180m2/g。
5. A process for preparing a medical antimicrobial breathable TPU film as described in any one of claims 1-3 comprising the steps of:
(1) preparing povidone iodine/TPU master batch: mixing the formula amount of the povidone iodine with a part of TPU particles, and then extruding and pelletizing the mixture by using a double-screw extruder;
(2) preparing a water absorbent, nano silicon dioxide and TPU mixed master batch: mixing the water absorbent, the nano silicon dioxide and a part of TPU particles according to the formula ratio, and then extruding and granulating by using a double-screw extruder;
(3) drying and mixing the materials: drying the TPU particles with the rest formula amount, the povidone iodine/TPU master batch prepared in the step (1), the water absorbent prepared in the step (2), the mixed master batch of the nano silicon dioxide and the TPU, and the dimethyl silicon oil, the calcium carbonate crystal whiskers and the chitosan fibers with the formula amount to remove moisture, and then uniformly mixing all the materials;
(4) film forming: and (3) conveying the mixed material in the step (2) into a casting machine, and extruding to form a film.
6. The method for preparing medical antibacterial breathable TPU film according to claim 5, wherein in the step (3), the drying and water removal method comprises the following steps: firstly drying the mixture by hot air at 80-85 ℃ for 1-1.5 h, and then dehumidifying and drying the mixture at 95-100 ℃ for 2-3 h.
7. The preparation method of the medical antibacterial breathable TPU film according to claim 5, wherein the extrusion film forming process conditions are as follows: the temperature of the charging barrel is 155-165 ℃; the temperature of the filter screen is 175-180 ℃; the temperature of the elbow is 178-185 ℃; the connection temperature is 180-190 ℃; the temperature of the die head is 195-200 ℃.
8. The method for preparing medical antibacterial breathable TPU film according to claim 5, wherein in the step (3), the total water content of the dried and dewatered material is less than 0.01%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011240189.3A CN112409777A (en) | 2020-11-09 | 2020-11-09 | Medical antibacterial breathable TPU film and preparation method thereof |
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| CN202011240189.3A CN112409777A (en) | 2020-11-09 | 2020-11-09 | Medical antibacterial breathable TPU film and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115975371A (en) * | 2022-12-28 | 2023-04-18 | 昆山红苹果塑胶新材料有限公司 | A kind of anti-slip TPU film when encountering water and preparation method thereof |
| CN116656114A (en) * | 2023-04-28 | 2023-08-29 | 广东金发科技有限公司 | A special composite functional masterbatch for TPU film, TPU film, composite non-woven fabric and preparation method thereof |
| WO2024043990A1 (en) * | 2022-08-24 | 2024-02-29 | Kimberly-Clark Worldwide, Inc. | Moisture absorbent films and face masks incorporating the films |
| CN117866417A (en) * | 2024-01-10 | 2024-04-12 | 广东中鼎科技发展有限公司 | A waterproof, breathable, antibacterial and highly elastic TPU film for wound care and a preparation method thereof |
| CN118404873A (en) * | 2024-04-30 | 2024-07-30 | 高梵(浙江)信息技术有限公司 | Anti-mite antibacterial down jacket fabric and preparation method thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130105A (en) * | 2007-09-13 | 2008-02-27 | 郑州大学 | Povidone-iodine hydrogel wound dressing and radiation preparation method thereof |
| CN102294048A (en) * | 2011-07-21 | 2011-12-28 | 浙江理工大学 | Preparation method for polyurethane and sericin medical composite membrane with properties of water absorption and moisture permeation |
| CN105497967A (en) * | 2016-01-20 | 2016-04-20 | 李绍旭 | Dry bacterial cellulose membrane dressing |
| CN105907082A (en) * | 2016-06-08 | 2016-08-31 | 东莞市雄林新材料科技股份有限公司 | TPU film used for medical product and preparation method of TPU film |
| CN106798944A (en) * | 2017-01-16 | 2017-06-06 | 广州弘泰塑胶科技有限公司 | TPU medical treatment application films and preparation method thereof |
| CN107057021A (en) * | 2017-03-22 | 2017-08-18 | 上海恒安聚氨酯股份有限公司 | High permeation waterproof humidity-permeant TPUE of heat-resistance type and preparation method thereof |
| CN107987239A (en) * | 2017-12-13 | 2018-05-04 | 郑小华 | A kind of waterproof and breathable TPU film and preparation method thereof |
| CN108192331A (en) * | 2017-12-21 | 2018-06-22 | 东莞市雄林新材料科技股份有限公司 | A kind of corrosive TPU film of surgery high resistance to chemicals and preparation method thereof |
| CN108866811A (en) * | 2018-07-24 | 2018-11-23 | 合肥旭亚新材料科技有限公司 | A kind of ventilative medical non-woven fabrics of high water absorption height |
| CN111303618A (en) * | 2019-12-20 | 2020-06-19 | 山东一诺威聚氨酯股份有限公司 | Organic silicon modified TPU medical catheter and preparation method thereof |
-
2020
- 2020-11-09 CN CN202011240189.3A patent/CN112409777A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130105A (en) * | 2007-09-13 | 2008-02-27 | 郑州大学 | Povidone-iodine hydrogel wound dressing and radiation preparation method thereof |
| CN102294048A (en) * | 2011-07-21 | 2011-12-28 | 浙江理工大学 | Preparation method for polyurethane and sericin medical composite membrane with properties of water absorption and moisture permeation |
| CN105497967A (en) * | 2016-01-20 | 2016-04-20 | 李绍旭 | Dry bacterial cellulose membrane dressing |
| CN105907082A (en) * | 2016-06-08 | 2016-08-31 | 东莞市雄林新材料科技股份有限公司 | TPU film used for medical product and preparation method of TPU film |
| CN106798944A (en) * | 2017-01-16 | 2017-06-06 | 广州弘泰塑胶科技有限公司 | TPU medical treatment application films and preparation method thereof |
| CN107057021A (en) * | 2017-03-22 | 2017-08-18 | 上海恒安聚氨酯股份有限公司 | High permeation waterproof humidity-permeant TPUE of heat-resistance type and preparation method thereof |
| CN107987239A (en) * | 2017-12-13 | 2018-05-04 | 郑小华 | A kind of waterproof and breathable TPU film and preparation method thereof |
| CN108192331A (en) * | 2017-12-21 | 2018-06-22 | 东莞市雄林新材料科技股份有限公司 | A kind of corrosive TPU film of surgery high resistance to chemicals and preparation method thereof |
| CN108866811A (en) * | 2018-07-24 | 2018-11-23 | 合肥旭亚新材料科技有限公司 | A kind of ventilative medical non-woven fabrics of high water absorption height |
| CN111303618A (en) * | 2019-12-20 | 2020-06-19 | 山东一诺威聚氨酯股份有限公司 | Organic silicon modified TPU medical catheter and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 《机械工程师手册》第二版编辑委员会编: "《机械工程师手册》", 30 June 2000, 机械工业出版社 * |
| 张莉等: "亲水性聚氨酯在医用敷料方面的应用", 《化学推进剂与高分子材料》 * |
| 胡丹丹: "医用聚氨酯共混膜的制备及其性能研究", 《中国优秀博硕士学位论文全文数据库(硕士)工程科技Ⅰ辑》 * |
| 董秉直等著: "《饮用水膜法处理新技术》", 30 September 2015, 同济大学出版社 * |
| 谢富春等: "防水透气聚氨酯薄膜及涂层的研究和应用", 《化学推进剂与高分子材料》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024043990A1 (en) * | 2022-08-24 | 2024-02-29 | Kimberly-Clark Worldwide, Inc. | Moisture absorbent films and face masks incorporating the films |
| GB2637877A (en) * | 2022-08-24 | 2025-08-06 | Kimberly Clark Co | Moisture absorbent films and face masks incorporating the films |
| CN115975371A (en) * | 2022-12-28 | 2023-04-18 | 昆山红苹果塑胶新材料有限公司 | A kind of anti-slip TPU film when encountering water and preparation method thereof |
| CN116656114A (en) * | 2023-04-28 | 2023-08-29 | 广东金发科技有限公司 | A special composite functional masterbatch for TPU film, TPU film, composite non-woven fabric and preparation method thereof |
| CN117866417A (en) * | 2024-01-10 | 2024-04-12 | 广东中鼎科技发展有限公司 | A waterproof, breathable, antibacterial and highly elastic TPU film for wound care and a preparation method thereof |
| CN117866417B (en) * | 2024-01-10 | 2024-06-07 | 广东中鼎科技发展有限公司 | Waterproof breathable antibacterial high-elastic TPU film for wound care and preparation method thereof |
| CN118404873A (en) * | 2024-04-30 | 2024-07-30 | 高梵(浙江)信息技术有限公司 | Anti-mite antibacterial down jacket fabric and preparation method thereof |
| CN118404873B (en) * | 2024-04-30 | 2025-09-16 | 高梵(浙江)信息技术有限公司 | Anti-mite antibacterial down jacket fabric and preparation method thereof |
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