CN110721333A - Antiallergic dressing used after anesthesia and preparation method thereof - Google Patents

Abstract

The invention discloses an anti-allergic dressing used after anesthesia and a preparation method thereof, belonging to the technical field of medical dressings in anesthesia. The drug-loading layer is prepared from calcium alginate composite fibers loaded with anti-allergic gel particles, and the anti-allergic gel particles include a calcium alginate shell layer and an anti-allergic liquid filled in the calcium alginate shell layer. . The dressing of the invention has an anti-allergic effect, can also alleviate the allergic symptoms that have occurred in a patient, and also has the effect of relieving pain and sterilizing.

Description

A kind of anti-allergic dressing for post-anesthesia and preparation method thereof

technical field

The invention relates to the technical field of anesthesia medical dressings, in particular to an anti-allergic dressing used after anesthesia and a preparation method thereof.

Background technique

Regarding anesthesia technology, the earliest written record in the world is the Mafei Decoction invented by Hua Tuo, a famous ancient Chinese surgical expert and Chinese medicine scientist, which appeared in the Han Dynasty in my country. Ma Fei Tang is a traditional Chinese medicine decoction equivalent to the current oral general anesthesia. After oral administration, the patient loses skin sensation and facilitates the operation. Later, Western medicine invented various anesthetics, such as lidocaine, bupivacaine, procaine and so on. Anesthesia is a reversible functional inhibition of the central and peripheral nervous systems produced by drugs or other methods, which is mainly characterized by loss of sensation, especially pain.

Now anesthesia is not only used for sensory shielding in major surgery, but also for pain relief of wounds, which is convenient for wound cleaning and suturing. Dressings are often used during anesthesia, such as block anesthesia, which is to inject local anesthetics into the nerve trunk. Or around the main branch to block the afferent stimulation of nerve endings, so that the nerve distribution area has an anesthetic effect, and the puncture point is covered with a dressing after the needle is withdrawn. At present, the commonly used dressing materials include gauze, oil gauze, calcium alginate dressing, hydrocolloid dressing, etc. Among them, the skin covered by gauze, oil gauze and other dressings is covered by repeated contact with disinfectant and viscous dressings, and the skin in the season when the temperature rises. Sweat is irritated, and some patients may experience sweating of the skin around the puncture point, which affects the adhesive barrier function of the transparent dressing. Some patients, especially the elderly, may experience irritant dermatitis caused by skin irritation from the edge of the dressing after long-term use. The patient presented with redness, itching, pain, blisters and other symptoms of the skin at the edge of the dressing. Among them, calcium alginate dressings are more and more widely used because of their excellent properties such as non-toxicity, non-immunogenicity, and biodegradability. It has the characteristics of high uniformity and poor spinnability. It is usually made in non-woven form, which is easy to cause cracks in the right-angle direction, resulting in low strength and poor durability of the dressing, and the dressing will warp and fall off. Therefore, there is an urgent need for an anti-allergic calcium alginate fiber dressing with high strength and not easy to tear.

SUMMARY OF THE INVENTION

In view of this, the purpose of the present invention is to provide an anti-allergic dressing after anesthesia and a preparation method thereof, the anti-allergic dressing is used to cover the puncture point after anesthesia, and the prepared dressing has anti-allergic effect and can slow down Allergic symptoms that the patient has already appeared, but also has the effect of pain relief and bactericidal.

The present invention solves the above-mentioned technical problems through the following technical means:

An anti-allergic dressing used after anesthesia, the anti-allergic dressing comprises a non-woven fabric and a drug-loading layer bonded on the non-woven fabric, and the drug-loading layer is calcium alginate loaded with anti-allergic gel particles The anti-allergic gel particles are prepared from composite fibers, and the anti-allergic gel particles include a calcium alginate shell layer and an anti-allergic medicinal liquid filled in the calcium alginate shell layer.

Further, the calcium alginate composite fiber is mainly prepared by compounding sodium alginate and short cotton fiber according to the mass ratio of (20-25):(4-8).

Further, the mass ratio of the calcium alginate composite fiber and the anti-allergic gel particles is (24-33):(3-8), and the particle size of the anti-allergic gel particles is 0.2-0.5 mm.

Further, the anti-allergic liquid includes the following components: ethyl paraben, menthol extract, Kochia extract, pearl powder, Nepeta extract, parsnip extract, honeysuckle extract, goldenrod flower extract, Lobelia Extract.

Further, the anti-allergic gel particles include the following raw materials in parts by weight: 40-56 parts of carboxymethyl cellulose, 35-45 parts of sodium alginate, 10 parts of glycerin, 0.1 part of ethylparaben, 1-2 parts of Menthol Extract, 1-3 Parts Kochia Extract, 2-3 Parts Pearl Powder, 5-6 Parts Nepeta Extract, 3-5 Parts Parsnip Extract, 0.5-1 Parts Honeysuckle Extract, 0.05-0.1 Parts Parts Solidago Extract, 0.05-0.2 Parts Lobelia Extract.

Further, the area ratio of the non-woven fabric to the drug-loading layer is 1:(0.8-0.9).

Further, the present invention also discloses the preparation method of the anti-allergic dressing. The short cotton fibers and the anti-allergic gel particles are added to the saturated sodium alginate solution, and the obtained mixed spinning solution is subjected to spinning by a wet spinning machine. It is sprayed out of the hole to a coagulation bath at 45°C, and precipitated. The obtained fiber is drawn and stretched by a drawing roller to obtain a calcium alginate composite fiber loaded with anti-allergic gel particles, and the dried calcium alginate composite fiber is formed. Drug-loading layer; steam the non-woven fabric under water vapor for 20-30min, then dry to a water content of 30-40%, heat the drug-loading layer to 80-85°C, and stick the drug-loading layer to the The anti-allergic dressing is obtained on the spinning cloth, which is naturally air-dried at room temperature, and sealed and stored aseptically.

Further, the preparation of the drug-loading layer includes the following steps:

Preparation of mixed spinning solution: slowly dissolve sodium alginate in deionized water, stir at a speed of 400-600rpm for 1-2h to obtain sodium alginate solution, add short cotton fiber and defoamer to the sodium alginate solution, After stirring at 1000-1500rpm for 1-2h, add anti-allergic gel particles, and stir and disperse at a speed of 300-500rpm for 20-30min to obtain a mixed spinning solution;

Preparation of coagulation bath: prepare a mixed solution of ethanol-calcium chloride, and adjust the pH of the mixed solution=6.5-7 to obtain a coagulation bath;

Preparation of calcium alginate composite fiber: Under the conditions of ambient temperature of 30 °C and relative humidity of ≤65%, the spinning hole of the wet spinning machine ejects the mixed spinning solution into a coagulation bath at 45 °C, and spins with a single nozzle. The rate is 10ml/h, and the mixed spinning solution is precipitated in the coagulation bath to obtain fibers, which are stretched to 1 times by the fiber drawing roller, washed with distilled water, and dried to obtain a calcium alginate composite loaded with anti-allergic gel particles. Fiber, the diameter of the calcium alginate composite fiber is 0.6-1mm;

Preparation of drug-loaded layer: the dried calcium alginate composite fiber is woven into a drug-loaded layer with a thickness of 0.5-0.8 cm by warp and weft weaving.

Further, the volume ratio of the coagulation bath to the mixed spinning solution is 3:1.

Further, the ethanol concentration in the ethanol-calcium chloride mixed solution is 45-55 wt %, and the calcium chloride concentration is 4-5 wt %.

Further, the preparation steps of the anti-allergic gel particles are as follows:

Add sodium carboxymethyl cellulose into deionized water, after it is completely dissolved, add glycerin and ethyl paraben and stir well, then add menthol extract, Kochia extract, pearl powder, Nepeta extract, and wind extract extract, honeysuckle extract, goldenrod extract, lobelia extract are mixed into a paste, the paste is added to 3-5wt% sodium alginate solution, dispersed into a suspension by 25kHz ultrasonic wave, the suspension droplets Put it into saturated calcium lactate solution, and remove it to obtain anti-allergic gel particles.

An anti-allergic dressing for anesthesia and a preparation method thereof provided by the present invention have the following beneficial effects:

1. The anti-allergic dressing of the present invention is used for fixing intravenous catheters. The surface layer in the double-layer structure of the dressing is a drug-carrying layer, the drug-carrying layer directly contacts the skin, and the bottom layer is a medical non-woven fabric; the antibacterial effect of the medical non-woven fabric and the The ventilation effect is good, and the waterproof and stretchability are good, and the area is larger than the drug-loading layer, so the bottom layer completely covers the surface layer, which can reduce the invasion of bacteria and liquid, and the drug-loading layer of the surface layer is loaded with anti-allergic liquid. It can prevent the patient from being allergic to the adhesive on the outer side of the drug-loading layer. If allergic symptoms have already occurred, the allergic adverse reactions can be alleviated.

2. Calcium alginate composite fiber is non-toxic and harmless. It is a pure natural green material. It can absorb the exudate from the wound where the venous catheter is placed, remove the breeding place of bacteria, and can also absorb bacteria to achieve the purpose of antibacterial. When the calcium alginate composite fiber is prepared, the mixed spinning solution prepared by sodium alginate and short cotton fiber is mixed with anti-allergic gel particles. The anti-allergic gel particles, calcium alginate composite fiber not only has antibacterial effect but also has the advantages of anti-allergic, and short cotton fiber increases the toughness of calcium alginate composite fiber.

3. The anti-allergic gel particles contain a variety of traditional Chinese medicine extracts, which have anti-allergic, anti-inflammatory, antibacterial, analgesic, and antipruritic effects. They are mixed with sodium alginate to prepare a suspension and then added dropwise to the calcium lactate solution to form an external It is calcium alginate gel with anti-allergic gel particles inside of anti-allergic liquid. Calcium alginate gel has a certain slow-release effect, which can prolong the efficacy of anti-allergic liquid and achieve the purpose of continuous administration.

Detailed ways

The present invention will be described in detail below in conjunction with specific embodiments:

Example 1: Anti-allergic dressing preparation one

The preparation of anti-allergic dressing should prepare anti-allergic gel particles, and its preparation method is as follows:

Add 40g of sodium carboxymethyl cellulose to 500ml of deionized water and stir. After it is completely dissolved, add 10g of glycerin and 0.1g of ethylparaben and stir evenly. Then add 1g of menthol extract, 2g of Kochia radix extract, and 3g of pearl. Powder, 5g Nepeta extract, 3g Parsnip extract, 0.5g Honeysuckle extract, 0.1g Solidago extract, 0.2g Lobelia extract were mixed into a paste, and the paste was added to 35g sodium alginate to prepare the concentration In a 4wt% sodium alginate solution, 25kHz ultrasonic wave is used to disperse into a suspension, drop the suspension into a saturated calcium lactate solution, and filter to obtain anti-allergic gel particles. After testing, the particle size of the prepared antiallergic gel particles is 0.2-0.5 mm.

After the antiallergic gel particles are prepared, the drug-loading layer is prepared, and the preparation method is as follows:

Preparation of mixed spinning solution: 200g of sodium alginate was slowly dissolved in 2000ml of deionized water, stirred at a speed of 400rpm for 2h to obtain a saturated sodium alginate solution, and 40g of 0.5-1mm long short cotton fibers and 2g of DSA-5 were eliminated. The foaming agent was added to the saturated sodium alginate solution, and after stirring at 1000 rpm for 2 hours, 30 g of the prepared anti-allergic gel particles were added, and after stirring at a speed of 300 rpm for 20 minutes, a mixed spinning solution was obtained;

Preparation of coagulation bath: prepare a mixed solution of ethanol-calcium chloride, wherein the concentration of ethanol is 45wt%, the concentration of calcium chloride is 5wt%, and the pH of the mixed solution is adjusted to 6.5 to obtain a coagulation bath, and the volume ratio of the coagulation bath to the mixed spinning solution is 3:1;

Preparation of calcium alginate composite fiber: Under the conditions of ambient temperature of 30 °C and relative humidity of ≤65%, the spinning hole of the wet spinning machine ejects the mixed spinning solution into the coagulation bath at 45 °C, and the spinning of single nozzle The spinning rate is 10ml/h, the spinning voltage is controlled to 15kv, the spinning solution is precipitated in the coagulation bath, and the fiber is obtained, which is stretched to 1 times by the drawing roller, washed with distilled water, and dried at 35 °C to obtain a loaded fiber. The calcium alginate composite fiber of the anti-allergic gel particles is measured, and the diameter of the calcium alginate composite fiber is about 1mm;

Preparation of drug-loading layer: The dried calcium alginate composite fiber is woven into a rectangular drug-loading layer with a width of 5×5cm and a thickness of 0.8cm by warp and weft knitting.

Anti-allergic dressing preparation:

Steam the 6.2×6.2cm medical non-woven fabric under water vapor for 20min, then take it out, dry it to a water content of 30%, heat the prepared drug-loading layer in a water bath to 80°C, and stick the drug-loading layer on the On the non-woven fabric, after pressing for 30s, air-dry naturally at room temperature, and seal it for aseptic storage.

Example 2: Anti-allergic dressing preparation II

The preparation of anti-allergic dressing should prepare anti-allergic gel particles, and its preparation method is as follows:

Add 50g of sodium carboxymethyl cellulose to 500ml of deionized water and stir. After it is completely dissolved, add 10g of glycerin and 0.1g of ethylparaben and stir evenly. Then add 2g of menthol extract, 3g of Kochia radix extract, and 2g of pearl. Powder, 6g Nepeta extract, 4g Parsnip extract, 0.5g Honeysuckle extract, 0.05g Solidago extract, 0.05g Lobelia extract were mixed into a paste, and the paste was added to 40g sodium alginate to prepare the concentration In 3wt% sodium alginate solution, 25kHz ultrasonic wave is used to disperse into a suspension, drop the suspension into a saturated calcium lactate solution, and filter to obtain anti-allergic gel particles. After testing, the particle size of the prepared antiallergic gel particles is 0.2-0.5 mm.

After the antiallergic gel particles are prepared, the drug-loading layer is prepared, and the preparation method is as follows:

Preparation of mixed spinning solution: Slowly dissolve 250g of sodium alginate in 2500ml of deionized water, stir at a rate of 500rpm for 1.5h to obtain a saturated sodium alginate solution, mix 80g of 0.5-1mm long short cotton fibers, 2g of DSA- 5. The defoamer is added to the saturated sodium alginate solution, and after stirring at 1200 rpm for 1 hour, 70 g of the prepared anti-allergic gel particles are added, and the mixed spinning solution is obtained after stirring at a speed of 300 rpm for 25 minutes;

Preparation of coagulation bath: prepare a mixed solution of ethanol-calcium chloride, wherein the concentration of ethanol is 50wt%, the concentration of calcium chloride is 4wt%, the concentration of 50wt% ethanol-4wt% calcium chloride mixed solution, and the pH of the mixed solution is adjusted to 7 to obtain a coagulation bath , the volume ratio of coagulation bath and mixed spinning solution is 3:1;

Preparation of calcium alginate composite fiber: Under the conditions of ambient temperature of 30 °C and relative humidity of ≤65%, the spinning hole of the wet spinning machine ejects the mixed spinning solution into the coagulation bath at 45 °C, and the spinning of single nozzle The spinning rate was 10ml/h, the spinning voltage was controlled to 15kv, the spinning solution was precipitated in the coagulation bath, and the fiber was obtained, which was stretched to 1 times by the drawing roller, washed with distilled water, and dried at 30 °C to obtain a loaded fiber. The calcium alginate composite fiber of the anti-allergic gel particles is measured, and the diameter of the calcium alginate composite fiber is about 0.9mm;

Preparation of drug-loaded layer: The dried calcium alginate composite fiber is woven into a rectangular drug-loaded layer with a width of 5×5cm and a thickness of 0.5cm by warp and weft weaving.

Anti-allergic dressing preparation:

The 5.6×5.6cm medical non-woven fabric was steamed under water vapor for 30min, then taken out, dried to a water content of 35%, heated to 82°C in a water bath of the prepared drug-loaded layer, and then adhered to the drug-loaded layer while it was still hot. On the non-woven fabric, after pressing for 30s, air-dry naturally at room temperature, and seal it for aseptic storage.

Example 3: Anti-allergic dressing preparation three

The preparation of anti-allergic dressing should prepare anti-allergic gel particles, and its preparation method is as follows:

Add 60g of sodium carboxymethyl cellulose to 500ml of deionized water and stir. After it is completely dissolved, add 10g of glycerin and 0.1g of ethyl paraben and stir evenly. Then add 2g of menthol extract, 1g of Kochia seed extract and 2g of pearl. Powder, 6g Nepeta extract, 5g Parsnip extract, 1g honeysuckle extract, 0.1g Solidago extract, 0.1g Lobelia extract were mixed into a paste, and the paste was added to 45g sodium alginate to prepare a concentration of In 3wtwt% sodium alginate solution, 25kHz ultrasonic wave is used to disperse into a suspension, drop the suspension into a saturated calcium lactate solution, and filter to obtain anti-allergic gel particles. After testing, the particle size of the prepared antiallergic gel particles is 0.2-0.5 mm.

After the antiallergic gel particles are prepared, the drug-loading layer is prepared, and the preparation method is as follows:

Preparation of mixed spinning solution: slowly dissolve 200g of sodium alginate in 2000ml of deionized water, stir at a rate of 600rpm for 2h to obtain a saturated sodium alginate solution, dissolve 60g of 0.5-1mm long short cotton fibers and 2g of DSA-5. The foaming agent was added to the saturated sodium alginate solution, and after stirring at 1500 rpm for 1 hour, 80 g of the prepared anti-allergic gel particles were added, and the mixed spinning solution was obtained after stirring at a speed of 300 rpm for 30 minutes;

Preparation of coagulation bath: prepare a mixed solution of ethanol-calcium chloride, wherein the concentration of ethanol is 55wt%, the concentration of calcium chloride is 4wt%, and the pH of the mixed solution is adjusted to 7 to obtain a coagulation bath, the volume ratio of the coagulation bath to the mixed spinning solution is 3:1;

Preparation of calcium alginate composite fiber: Under the conditions of ambient temperature of 30 °C and relative humidity of ≤65%, the spinning hole of the wet spinning machine ejects the mixed spinning solution into the coagulation bath at 45 °C, and the spinning of single nozzle The spinning rate was 10ml/h, the spinning voltage was controlled to 15kv, the spinning solution was precipitated in the coagulation bath, and the fiber was obtained, which was stretched to 1 times by the drawing roller, washed with distilled water, and dried at 30 °C to obtain a loaded fiber. The calcium alginate composite fiber of the anti-allergic gel particles is measured, and the diameter of the calcium alginate composite fiber is about 0.7mm;

Preparation of drug-loading layer: The dried calcium alginate composite fiber is woven into a rectangular drug-loading layer with a width of 5×5cm and a thickness of 0.7cm by warp and weft weaving.

Anti-allergic dressing preparation:

Steam the 6×6cm medical non-woven fabric under water vapor for 25min, then take it out, dry it to a moisture content of 40%, heat the prepared drug-loading layer in a water bath to 85°C, and stick the drug-loading layer to the non-woven fabric while it is still hot. On the spinning cloth, after pressing for 30s, air-dry naturally at room temperature, and seal it for aseptic storage.

The anti-allergic dressings prepared in Examples 1-3 were measured, and the breaking strength of the dry anti-allergic dressing was 3.0-3.5 cN/dtex, and the breaking strength of the wet anti-allergic dressing was 2.0-2.9 cN/dtex, indicating that the prepared anti-allergic dressing was strong enough ,Durable.

The above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced. Without departing from the spirit and scope of the technical solutions of the present invention, all of them should be included in the scope of the claims of the present invention. The technology, shape, and structural part that are not described in detail in the present invention are all well-known technologies.

Claims (9)

1. The utility model provides an antiallergic dressing for after anesthesia, its characterized in that, antiallergic dressing includes the non-woven fabrics and bonds the medicine-carrying layer on the non-woven fabrics, the medicine-carrying layer is prepared for the calcium alginate composite fiber who loads the antiallergic gel granule, the antiallergic gel granule includes calcium alginate shell and fills the antiallergic liquid in calcium alginate shell.

2. The anti-allergic dressing used after anesthesia is characterized in that the calcium alginate composite fiber is mainly prepared from sodium alginate and short cotton fiber according to the mass ratio of (20-25): (4-8) compounding and preparing.

3. The anti-allergic dressing used after anesthesia is characterized in that the mass ratio of the calcium alginate composite fiber to the anti-allergic gel particles is (24-33) - (3-8), and the particle size of the anti-allergic gel particles is 0.2-0.5 mm.

4. The anti-allergic dressing used after anesthesia of claim 3, wherein the anti-allergic liquid comprises the following components: ethyl hydroxybenzoate, menthol extract, fructus Kochiae extract, pearl powder, herba Schizonepetae extract, radix Saposhnikoviae extract, flos Lonicerae extract, herba Solidaginis extract, and herba Lobeliae chinensis extract.

5. The antiallergic dressing used after anesthesia as claimed in claim 4, wherein the antiallergic gel particles comprise the following raw materials in parts by weight: 40-56 parts of carboxymethyl cellulose, 35-45 parts of sodium alginate, 10 parts of glycerol, 0.1 part of ethylparaben, 1-2 parts of menthol extract, 1-3 parts of fructus kochiae extract, 2-3 parts of pearl powder, 5-6 parts of herba schizonepetae extract, 3-5 parts of radix sileris extract, 0.5-1 part of honeysuckle extract, 0.05-0.1 part of goldenrod extract and 0.05-0.2 part of Chinese lobelia extract.

6. The method for preparing an antiallergic dressing used after anesthesia as set forth in claim 5, characterized in that the method comprises the following steps:

adding short cotton fibers and antiallergic gel particles into a saturated sodium alginate solution, spraying the obtained mixed spinning solution into a coagulating bath at 45 ℃ through a spinneret orifice of a wet spinning machine, separating out, drawing and stretching the obtained fibers through a drawing roller to obtain calcium alginate composite fibers loaded with the antiallergic gel particles, and forming a drug-loaded layer on the dried calcium alginate composite fibers; steaming nonwoven fabric in water vapor for 20-30min, drying to water content of 30-40%, heating the medicine-carrying layer to 80-85 deg.C, sticking the medicine-carrying layer on the nonwoven fabric while it is hot to obtain antiallergic dressing, naturally air drying at room temperature, sealing, and aseptically storing.

7. The preparation method of the antiallergic dressing used after anesthesia as claimed in claim 6, characterized in that the preparation method of the drug-loaded layer comprises the following steps:

preparing mixed spinning solution: slowly dissolving sodium alginate in deionized water, stirring at the speed of 400-;

preparing a coagulating bath: preparing an ethanol-calcium chloride mixed solution, and adjusting the pH value of the mixed solution to 6.5-7 to obtain a coagulating bath;

preparing calcium alginate composite fibers: under the conditions that the ambient temperature is 30 ℃ and the relative humidity is less than or equal to 65%, a spinneret orifice of a wet spinning machine sprays mixed spinning solution into a coagulation bath at the temperature of 45 ℃, the single-nozzle spinning speed is 10ml/h, the mixed spinning solution is separated out from the coagulation bath to obtain fibers, a fiber drawing roller is drawn and stretched to 1 time, then the fibers are cleaned by distilled water, and the calcium alginate composite fibers loaded with antiallergic gel particles are obtained after drying, wherein the diameter of the calcium alginate composite fibers is 0.6-1 mm;

preparing a drug-loaded layer: the dried calcium alginate composite fiber is woven into a drug-loaded layer with the thickness of 0.5-0.8cm by adopting a warp-weft weaving method.

8. The method for preparing an antiallergic dressing used after anesthesia as claimed in claim 7, wherein the ethanol concentration in the ethanol-calcium chloride mixed solution is 45-55 wt%, and the calcium chloride concentration is 4-5 wt%.

9. The method for preparing an antiallergic dressing used after anesthesia as claimed in claim 8, wherein the antiallergic gel particles are prepared by the following steps:

adding sodium carboxymethylcellulose into deionized water, dissolving completely, adding glycerol and ethylparaben, stirring, adding Mentholum extract, Kochiae fructus extract, Margarita powder, herba Schizonepetae extract, radix Saposhnikoviae extract, flos Lonicerae extract, herba Solidaginis extract, and herba Lobeliae chinensis extract, mixing to obtain paste, adding the paste into 3-5 wt% sodium alginate solution, dispersing with 25kHz ultrasonic wave to obtain suspension, dripping the suspension into saturated calcium lactate solution, and taking out to obtain antiallergic gel granule.