CN118170058B - Spherical focused ultrasonic transducer control system, method, terminal and treatment equipment - Google Patents
Spherical focused ultrasonic transducer control system, method, terminal and treatment equipment Download PDFInfo
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Abstract
The invention belongs to the technical field of general control and regulation, and discloses a spherical focusing ultrasonic transducer control system, a method, a terminal and treatment equipment. The control system comprises an upper computer, a communication unit, a signal processing unit, a signal output unit and a driving unit. The upper computer generates a treatment instruction based on the targeted tissue data, the communication unit receives the treatment instruction sent by the upper computer and sends the treatment instruction to the signal processing unit, the signal processing unit generates a control signal and an original electric excitation signal based on the treatment instruction, the signal output unit receives and outputs the control signal and the original electric excitation signal to each driving unit, and the driving unit receives the control signal and the original electric excitation signal so as to drive the spherical multi-chip array focusing ultrasonic transducer to work according to preset emission dosage, preset emission time, preset interval time, preset emission area, preset emission mode and preset emission frequency. The control method is executed by a control system and is used for optimizing treatment and improving the treatment effect of the cancer.
Description
Technical Field
The invention belongs to the technical field of general control and regulation, and particularly relates to a spherical focusing ultrasonic transducer control system, a spherical focusing ultrasonic transducer control method, a spherical focusing ultrasonic transducer control terminal and a spherical focusing ultrasonic transducer treatment device.
Background
The high-intensity spherical focusing ultrasonic therapeutic equipment comprises a spherical focusing ultrasonic transducer as one of the core components. The spherical focusing ultrasonic transducers can be divided into two types according to the number of vibration elements, one type is a spherical single-chip self-focusing ultrasonic transducer, and the other type is a spherical multi-chip array focusing ultrasonic transducer. The spherical single-chip self-focusing ultrasonic transducer has the advantage of simple structure, but has the purposes that the machining precision is difficult to guarantee and the incidence direction and focal area of ultrasonic waves cannot be adjusted. The spherical multi-chip array focusing ultrasonic transducer is characterized by uniformly arranging multiple piezoelectric vibrating elements on a spherical support, and forming a high-power transducer by connecting the vibrating elements in series and/or in parallel. The goal of adjusting the incidence direction and focal domain of ultrasonic waves can be achieved through reasonable selection of piezoelectric vibrating elements in the spherical multi-piece array type focusing ultrasonic transducer, so that the spherical multi-piece array type focusing ultrasonic transducer, a control system/method for controlling the transducer and treatment equipment are important points of current researches.
Various functional units or histiocytes are included in human and animal tissues. Therapeutic ultrasound typically uses transducers to deliver energy to damaged tissue. If used for high intensity transducer ultrasound therapy, improper operation tends to cause treatment-related thermal effects to damage the target tissue. Thus, the study of therapeutic ultrasound non-thermal effects is an important aspect of therapeutic ultrasound research. In addition, prior studies have found that non-thermal effect ultrasound treatments (e.g., low intensity therapeutic ultrasound LIPUS) can improve healing time and healing quality for multiple tissue types. However, living tissue is highly structurally rigid and different types of tissue vary in depth within the body, resulting in an ultrasound treatment device that requires specific parameters. The ultrasonic energy and carrier frequency are two key parameters of therapeutic ultrasound. The research focus is on two aspects of ultrasonic emission frequency control and ultrasonic emission dosage control. The prior art discloses an ultrasonic output repetition frequency control method which can acquire the mapping relation between a target tissue type and ultrasonic emission frequency and determine the ultrasonic emission frequency according to the mapping relation. The prior art also discloses ultrasound therapy systems and dose control methods, but does not disclose control of the ultrasound emission dose. That is, the prior art does not provide a method/system for achieving accurate control of the ultrasound emission frequency, the ultrasound emission dosage, etc. based on a base signal or a base control unit.
However, in addition to the frequency of emission and the ultrasound emission dose, the pulse intensity, pulse type, pulse duration, and pulse repetition rate are also quite critical for treating the same type of tissue. Thus, existing spherical focused ultrasound transducer control systems are typically designed to treat a single type of tissue, and each treatment uses a specific, fixed and single ultrasound frequency, pulse intensity, pulse repetition rate, pulse duration, pulse ratio, and single waveform. However, the transducer treatment element typically requires substantial movement around the treatment region to avoid thermal damage to the target tissue.
The present invention is directed to overcoming one or more of the disadvantages set forth above and providing further related advantages.
Disclosure of Invention
The invention aims to provide a spherical focusing ultrasonic transducer control system, a method, a terminal and treatment equipment, which can control the spherical focusing ultrasonic transducer to emit ultrasonic waves according to a preset emission area, a preset emission mode, a preset emission time, a preset interval time, a preset emission dosage and a preset emission frequency based on four basic signals, and can meet objective requirements for diversification of control items in an actual treatment scheme so as to improve applicability and optimize treatment effect. Moreover, the application requirements of diversification can be met by adopting simpler logic control, and the device has the advantages of simple structure and low cost.
In order to achieve the above object, the present invention provides the following technical solutions:
In a first aspect, the present invention provides a control system for a spherical focusing ultrasonic transducer, where the spherical focusing ultrasonic transducer is a spherical multi-chip array focusing ultrasonic transducer, and is configured with M piezoelectric vibrating elements, N of the M piezoelectric vibrating elements are in a group, and together form M/N vibrating element units, where N vibrating elements located in the same vibrating element unit are connected in parallel, in series, or in series-parallel. The control system comprises an upper computer, a communication unit, a signal processing unit, a signal output unit and a driving unit. M/N driving units, namely one vibrating unit is correspondingly provided with one driving unit.
And the upper computer is internally provided with targeted tissue data, and the targeted tissue data comprises position coordinates, volume and depth from epidermis. Treatment instructions are generated based on the targeted tissue data.
The communication unit receives the treatment instruction sent by the upper computer and sends the treatment instruction to the signal processing unit.
The signal processing unit includes a complex programmable logic device, a microcontroller, a frequency signal source, and a frequency synthesizer. The complex programmable logic device receives the treatment instruction, carries out logic processing on the treatment instruction and then sends the treatment instruction to the microcontroller. The microcontroller receives the therapy instructions and generates a frequency gating signal, a power gating signal, a digital potentiometer control signal, and a frequency synthesizer control signal based on the therapy instructions. The frequency signal source generates an original signal with basic frequency, the original signal is sent to the frequency synthesizer, the frequency synthesizer simultaneously receives a frequency synthesizer control signal sent by the microcontroller to carry out frequency division processing on the original signal to obtain an original electric excitation signal, and the original electric excitation signal, the power gating signal, the digital potentiometer control signal and the frequency gating signal are sent to at least one of M/N driving units through the signal output unit.
Each driving unit includes a driving circuit and an output circuit. The driving circuit comprises a gating sub-circuit, a digital potentiometer, a power chip and a logic sub-circuit. The output circuit includes a resonant subcircuit and an impedance transformation subcircuit. The gating sub-circuit receives and adjusts the serial power gating signal and the digital potentiometer control signal into parallel signals, then sends the power gating signal to the power chip, and sends the digital potentiometer control signal to the digital potentiometer to generate direct current voltage. The direct-current voltage is sent to the harmonic oscillator circuit, is subjected to chopper processing by the harmonic oscillator circuit and forms a sine wave by the impedance transformation sub circuit, and the sine wave is used for driving the vibrator unit so that the vibrator unit emits ultrasonic waves according to a preset emission dose.
The logic sub-circuit receives and processes the frequency gating signal and the original electric excitation signal, outputs a synchronous electric excitation signal, sends the synchronous electric excitation signal to the harmonic oscillator circuit, and controls the harmonic oscillator circuit to be switched on/off according to the working frequency of the vibrator unit so that the vibrator unit emits ultrasonic waves according to the preset emission frequency. The impedance transformation sub-circuit is used for carrying out impedance matching on the vibrating element unit so that the vibrating element unit emits ultrasonic waves according to a preset emission frequency.
As a possible implementation, the microcontroller determines a plurality of treatment cycles according to the treatment instructions, and the driving unit alternately gates or does not gate in each treatment cycle, based on which a preset emission time and a preset interval time between two adjacent preset emission times are determined. And in the preset transmitting time, the microcontroller transmits the power gating signal and the digital potentiometer control signal to the driving unit through the signal output unit. The microcontroller transmits the frequency gating signal and the frequency synthesizer transmits the original electrical excitation signal to the driving unit through the signal output unit. Based on the above, the spherical focusing ultrasonic transducer transmits ultrasonic waves according to a preset transmission dosage and a preset transmission frequency in a preset transmission time.
As a possible implementation, the microcontroller terminates the transmission of the power gating signal and the digital potentiometer control signal to the drive unit via the signal output unit within a preset interval. The microcontroller terminates the transmission of the frequency gating signal and the frequency synthesizer terminates the transmission of the original electrical excitation signal to the drive unit via the signal output unit. Based on the above, the spherical focusing ultrasonic transducer stops transmitting ultrasonic waves according to the preset transmitting dose and the preset transmitting frequency within the preset interval time.
As one possible implementation, the microcontroller determines the number and positions of the strobes in the M/N vibrating element units based on the therapy instructions, based on which the microcontroller transmits the power gating signal, the digital potentiometer control signal, the frequency gating signal, and the frequency synthesizer transmits the original electrical excitation signal to the driving unit to be strobed through the signal output unit to cause the spherically focused ultrasound transducer to emit ultrasound according to the preset emission region.
As one possible implementation manner, the microcontroller receives an emission mode control instruction included in the treatment instruction to generate an emission mode control signal, the emission mode control signal is an enable signal, the enable signal is sent to the complex programmable logic device, the logic circuit in the complex programmable logic device is controlled to logically process an original frequency signal generated by the frequency signal source, so that the original frequency signal generates a continuous mode or a pulse mode, and the spherical focusing ultrasonic transducer is controlled to emit ultrasonic waves according to a preset emission mode.
As a possible implementation, the control system controls all vibrating element units to work at the same frequency, the same phase and the same excitation voltage. Or the control system controls all vibrating units to work at different frequencies, different phases and different excitation voltages. Or the control system controls at least one vibrating element unit to work under the same frequency, the same phase and the same excitation voltage, and other groups of vibrating element units do not work. The control is executed to realize the focus area adjustability of the spherical multi-piece array type focusing ultrasonic transducer.
In a second aspect, the present invention further provides a control method of a spherical focusing ultrasonic transducer, the control method being performed by the control system provided in the first aspect, the control method comprising:
and the upper computer is internally provided with targeted tissue data, and the targeted tissue data comprises position coordinates, volume and depth from epidermis. Treatment instructions are generated based on the targeted tissue data.
The communication unit receives the treatment instruction sent by the upper computer and sends the treatment instruction to the signal processing unit.
The complex programmable logic device of the signal processing unit receives the treatment instruction sent by the communication unit, carries out logic processing on the treatment instruction and then sends the treatment instruction to the microcontroller, and the microcontroller carries out decoding processing on the treatment instruction to generate a frequency gating signal, a power gating signal, a digital potentiometer control signal and a frequency synthesizer control signal. The frequency signal source generates an original signal with basic frequency, the original signal is sent to the frequency synthesizer, the frequency synthesizer simultaneously receives a frequency synthesizer control signal sent by the microcontroller to carry out frequency division processing on the original signal to obtain an original electric excitation signal, and the original electric excitation signal, the power gating signal, the digital potentiometer control signal and the frequency gating signal are controllably sent to at least one of M/N driving units through the signal output unit.
When the driving unit receives the signals, the gating sub-circuit receives and adjusts the serial power gating signals and the digital potentiometer control signals into parallel signals, then sends the power gating signals to the power chip, and sends the digital potentiometer control signals to the digital potentiometer to generate direct-current voltage. The direct-current voltage is sent to the harmonic oscillator circuit, is subjected to chopper processing by the harmonic oscillator circuit and forms a sine wave by the impedance transformation sub circuit, and the sine wave is used for driving the vibrator unit so that the vibrator unit emits ultrasonic waves according to a preset emission dose.
The logic sub-circuit receives and processes the frequency gating signal and the original electric excitation signal, outputs a synchronous electric excitation signal, sends the synchronous electric excitation signal to the harmonic oscillator circuit, and controls the harmonic oscillator circuit to be switched on/off according to the working frequency of the vibrator unit so that the vibrator unit emits ultrasonic waves according to the preset emission frequency. The impedance transformation sub-circuit is used for carrying out impedance matching on the vibrating element unit so that the vibrating element unit emits ultrasonic waves according to a preset emission frequency.
As one possible implementation, the original electric excitation signal, the power gating signal, the digital potentiometer control signal and the frequency gating signal are controllably transmitted to at least one of the M/N driving units via the signal output unit, including:
The microcontroller generates an emission area control signal based on the treatment instruction, and determines the number and positions of the strobes in the M/N vibrating element units based on the emission area control signal. Based on the above, the microcontroller transmits the power gating signal, the digital potentiometer control signal, the frequency gating signal and the frequency synthesizer to the driving unit to be gated through the signal output unit, so that the spherical focusing ultrasonic transducer transmits ultrasonic waves according to a preset transmitting area.
The microcontroller determines a plurality of treatment periods based on the treatment instructions, and the spherical focusing ultrasonic transducer alternately emits and stops in each treatment period, and based on the treatment periods, the preset emission time and the preset interval time between two adjacent preset emission times are determined. And in the preset transmitting time, the microcontroller transmits the power gating signal and the digital potentiometer control signal to the driving unit through the signal output unit. The microcontroller transmits the frequency gating signal and the frequency synthesizer transmits the original electrical excitation signal to the driving unit through the signal output unit. Based on this, the spherical focusing ultrasonic transducer transmits ultrasonic waves within a preset transmission time. And in the preset interval time, the microcontroller stops sending the power gating signal and the digital potentiometer control signal to the driving unit through the signal output unit. The microcontroller terminates the transmission of the frequency gating signal and the frequency synthesizer terminates the transmission of the original electrical excitation signal to the drive unit via the signal output unit. Based on this, the spherical focusing ultrasonic transducer terminates the emission of ultrasonic waves for a preset interval time.
The microcontroller receives the emission mode control instruction to generate an emission mode control signal, the emission mode control signal is an enabling signal, the enabling signal is sent to the complex programmable logic device, and the logic circuit in the microcontroller is controlled to logically process an original frequency signal generated by the frequency signal source so as to enable the original frequency signal to generate a continuous mode or a pulse mode, so that control of the emission mode is realized.
Under the condition that the preset transmitting area, the preset transmitting time, the preset interval time and the transmitting mode are determined, the spherical focusing ultrasonic transducer is controlled to transmit ultrasonic waves according to the preset transmitting frequency and the preset transmitting dosage according to the control method provided by the second aspect.
In a third aspect, the present invention also provides a terminal comprising a processor and a communication interface coupled to the processor; the processor is configured to execute a computer program or instructions to implement the spherical focusing ultrasound transducer control method according to the second aspect.
In a fourth aspect, the present invention further provides a therapeutic apparatus, which performs the spherical focusing ultrasound transducer control method according to the second aspect, or which applies the spherical focusing ultrasound transducer control system according to the first aspect.
Compared with the prior art, the invention has the following technical effects:
First, using the targeted tissue data (position coordinates, volume and depth from the epidermis) a treatment order can be determined from which the control signals ultimately used to control the transducer to emit ultrasound are determined. In order to optimize the therapeutic effect and the patient experience, under the control of the control signal, the transducer may work according to preset parameters, where the preset parameters may specifically include a preset emission area, a preset emission time, a preset interval time, a preset emission mode, a preset emission dose, and a preset emission frequency, to emit ultrasonic waves. The preset parameters can be determined by four basic parameters, namely, four basic parameters of an original electric excitation signal, a power gating signal, a digital potentiometer control signal and a frequency gating signal. Based on the above, the control system can meet diversified application requirements by adopting simpler logic control, not only can simplify the structure of the control system and reduce the cost, but also can improve the applicability of the control system and the treatment equipment and optimize the treatment effect.
Second, the power chip generates direct current voltage under the control of the power gating signal, the digital potentiometer adjusts the resistance value of the digital potentiometer under the control of the digital potentiometer control signal, and then the direct current voltage is adjusted, the direct current voltage is chopped by the harmonic oscillator circuit to form an approximate sine wave, the approximate sine wave is converted into a sine wave by the impedance conversion sub-circuit, and the voltage with the sine wave is the excitation voltage of the transducer, namely the preset emission dose. The digital potentiometer, the power chip, the harmonic oscillator circuit and the impedance transformation sub-circuit are matched to generate sine waves, so that the sine waves can be conveniently adjusted according to actual treatment requirements (the sine waves can be realized by adjusting the resistance value of the digital potentiometer), and the sine waves have the advantage of high adjustment precision.
Thirdly, the signal processing unit and the driving unit can adopt simpler devices to realize diversified functions, so that the cost can be reduced, and the drift and loss in the signal transmission process can be reduced, thereby improving the control precision.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention and do not constitute a limitation on the invention.
FIG. 1 is a logic block diagram of a control system provided by an embodiment of the present invention;
fig. 2 is a schematic diagram of a partition of a spherical focusing ultrasonic transducer according to an embodiment of the present invention;
FIG. 3 is a logic block diagram of a communication unit according to an embodiment of the present invention;
fig. 4 is a logic block diagram of a signal processing unit according to an embodiment of the present invention;
FIG. 5 is a logic block diagram of a driving unit according to an embodiment of the present invention;
fig. 6 is a signal processing flow of the signal output unit and the driving unit provided in the embodiment of the invention;
Reference numerals:
10-upper computer, 11-communication unit, 12-signal processing unit,
13-Signal output unit, 14-driving unit, 15-power module;
110-232 and 485 conversion modules, 111-first enhancement modules, 112-first isolation modules, 113-485 and UART conversion modules, 114-second enhancement modules, 115-second isolation modules,
116-485 And UART conversion modules;
120-complex programmable logic devices, 121-microcontrollers, 122-frequency signal sources,
123-Frequency synthesizer;
140-a driving circuit, 141-an output circuit;
1400-protection subcircuit, 1401-logic subcircuit, 1402-strobe subcircuit,
1403-Digital potentiometer, 1404-power chip;
1410-a resonant subcircuit, 1411-an impedance transformation subcircuit.
Detailed Description
In order to clearly describe the technical solution of the embodiments of the present invention, in the embodiments of the present invention, the words "first", "second", etc. are used to distinguish the same item or similar items having substantially the same function and effect. For example, the first threshold and the second threshold are merely for distinguishing between different thresholds, and are not limited in order. It will be appreciated by those of skill in the art that the words "first," "second," and the like do not limit the amount and order of execution, and that the words "first," "second," and the like do not necessarily differ.
In the present invention, the words "exemplary" or "such as" are used to mean serving as an example, instance, or illustration. Any embodiment or design described herein as "exemplary" or "for example" should not be construed as preferred or advantageous over other embodiments or designs. Rather, the use of words such as "exemplary" or "such as" is intended to present related concepts in a concrete fashion.
In the present invention, "at least one" means one or more, and "a plurality" means two or more. "and/or", describes an association relationship of an association object, and indicates that there may be three relationships, for example, a and/or B, and may indicate: a alone, a and B together, and B alone, wherein a, B may be singular or plural. The character "/" generally indicates that the context-dependent object is an "or" relationship. "at least one of" or the like means any combination of these items, including any combination of single item(s) or plural items(s). For example, at least one (one) of a, b or c may represent: a, b, c, a and b, a and c, b and c, or a, b and c, wherein a, b, c can be single or multiple.
The control system/method provided by the prior art has the problem of low control precision. In addition, the switching frequency control and the ultrasonic emission dosage control are control items directly related to the working performance of the spherical focusing ultrasonic transducer, and objective requirements for control item diversification in an actual treatment scheme cannot be met.
The invention belongs to the technical field of general control and regulation, and discloses a spherical focusing ultrasonic transducer control system, a method, a terminal and treatment equipment. The control system comprises an upper computer, a communication unit, a signal processing unit, a signal output unit and a driving unit. The upper computer generates a treatment instruction based on the targeted tissue data, the communication unit receives the treatment instruction sent by the upper computer and sends the treatment instruction to the signal processing unit, the signal processing unit generates a control signal and an original electric excitation signal based on the treatment instruction, the signal output unit receives and outputs the control signal and the original electric excitation signal to each driving unit, and the driving unit receives the control signal and the original electric excitation signal so as to drive the spherical multi-chip array focusing ultrasonic transducer to work according to preset emission dosage, preset emission time, preset interval time, preset emission area, preset emission mode and preset emission frequency. The control method is executed by a control system and is used for optimizing treatment and improving the treatment effect of the cancer.
The control system provided by the embodiment of the invention is used for controlling the spherical multi-chip array type focusing ultrasonic transducer to work according to preset emission dosage, preset emission time, preset interval time, preset emission area, preset emission mode and preset emission frequency. The spherical multi-piece array focusing ultrasonic transducer (hereinafter referred to as transducer) is configured with M piezoelectric vibrating elements, N of the M piezoelectric vibrating elements are in a group, M/N groups of vibrating element units (the vibrating element units can also be called as transduction units) are formed together, and N piezoelectric vibrating elements in the same group of vibrating element units are connected in parallel, in series or in series-parallel.
As an example, the ultrasonic transducer includes a plurality of planar piezoelectric vibrating pieces for converting electric energy into mechanical energy, each of which is well fixed to the base, and positive and negative electrode lead wires are welded to the planar piezoelectric vibrating pieces. The piezoelectric vibrating element is formed by the planar piezoelectric vibrating piece, the base and the positive and negative lead wires. The ultrasonic transducer further comprises a spherical bracket, a plurality of through mounting holes are uniformly formed in the spherical inner wall of the spherical bracket, and a piezoelectric vibrating element is correspondingly arranged in each mounting hole.
As an example, the mounting holes are provided with five to seven turns in total from the bottom to the top of the spherical bracket. The spherical bracket provided with the piezoelectric vibrating elements is uniformly divided into a plurality of sectors, and the piezoelectric vibrating elements with equal quantity are distributed in each sector. For the piezoelectric vibrating elements in each sector, the piezoelectric vibrating elements can be divided into a plurality of groups to form a plurality of vibrating element units. The piezoelectric vibrating elements in the same group can be electrically connected in any one of series connection, parallel connection or series-parallel connection.
For example, five to seven adjacent piezoelectric vibrating elements are formed into one vibrating element unit, and each transducer unit is connected to one driving unit 14, that is, the number of driving units 14 is equal to the number of transducer units.
The control system provided by the embodiment of the invention controls all vibrating element units to work under the same frequency, the same phase and the same excitation voltage, or any one or a combination of a plurality of vibrating element units to work under the same frequency, the same phase and the same excitation voltage.
Under the control of the control system, the spherical multi-piece array focusing ultrasonic transducer outputs high-intensity focusing ultrasonic, and the sound field output characteristic of the spherical multi-piece array focusing ultrasonic transducer meets the requirements of industry standards.
Referring to fig. 1, 2, 3, 4, 5 and 6, there are a control system, a partition map, a communication unit, a signal processing unit, a driving unit and a signal processing flow, respectively.
In a first aspect, an embodiment of the present invention provides a spherical focusing ultrasonic transducer control system, where the control system includes a host computer 10, a communication unit 11, a signal processing unit 12, a signal output unit 13, and a driving unit 14. Wherein, the upper computer 10 is internally provided with targeted tissue data, and the targeted tissue data comprises position coordinates, volume and depth from epidermis. Treatment instructions are generated based on the targeted tissue data, the treatment instructions including an emission dose control instruction, an emission frequency control instruction, an emission time control instruction, an interval time control instruction, an emission region control instruction, and an emission mode control instruction.
It should be further explained that the targeted tissue data may be determined based on B-mode images or CT images. For example, after the B-ultrasonic image or the CT image is acquired, the target tissue can be intuitively acquired from the image, the shape of the target tissue can be outlined by using a manual or computer image processing mode, the volume and the depth from the epidermis of the target tissue are calculated based on the shape of the target tissue, and meanwhile, after the target tissue is outlined, the space coordinates of the target tissue can be determined based on the absolute coordinate system of the control system.
On the basis, treatment instructions are generated by using the targeted tissue data, wherein the treatment instructions comprise an emission dosage control instruction, an emission frequency control instruction, an emission time control instruction, an interval time control instruction, an emission area control instruction and an emission mode control instruction.
As one example, generating treatment instructions using targeted tissue data specifically includes: the number of layers to be treated is derived from the longitudinal dimension of the targeted tissue, and the path of motion of each layer of the ultrasound transducer 16, which may be serpentine, etc., is derived from the lateral dimension of the targeted tissue. The emission time is calculated in combination with the defined focal domain size (for example, 2.3mm by 12 mm) so as to generate an emission time control instruction and an interval time control instruction.
The depth of the target tissue from the epidermis is used to calculate the DC power supply (the output voltage of the DC power supply is controllable between 0.1V and 25.5V) required by the power switch element for sending the ultrasonic emission dose, and an emission dose control instruction is generated based on the determined emission dose. The direct current power supply directly influences the output power of the transducer, i.e. the emitted dose.
The ultrasonic characteristics of different frequencies in biological tissues are different through experiments, and in order to adapt to the biological characteristics of the target tissues, the embodiment of the invention selects the emission frequency which is adaptive to the biological characteristics of the target tissues, for example, 0.9 MHz-2 MHz, and preferably 1.5MHz.
The size and the shape of the optimal focal domain for treatment are calculated based on the volume and the distribution condition of the target tissue, and the size and the shape of the actual focal domain are changed by adjusting the emission area, so that the size and the shape of the actual focal domain are consistent with those of the optimal focal domain.
As an example, referring to table 1 and fig. 2, the manner of adjusting the emission area provided in the embodiment of the present invention is: the spherical focusing ultrasonic transducer is divided into an I area (1/2/3), an II area (1/2/3), a III area (1/2/3), an IV area (1/2/3), a V area (1/2/3), a VI area (1/2/3) and an O area (A/B), and the focal area of the spherical focusing ultrasonic transducer finally presents different sizes and shapes by customizing the transmitting area of the transducer.
Table 1 spherical focused ultrasound transducer zoning
In practical applications, since ultrasound emission generates heat accumulation, in order to avoid burn of a patient caused by excessive heat accumulation, different emission modes are selected according to the total treatment duration (ultrasound emission duration), and the emission modes include pulse emission and continuous emission. The continuous emission mode is suitable for treatment scenes with small targeted tissue size, short treatment time and the like and unobvious heat accumulation, so that the treatment efficiency is improved. The pulse emission mode is suitable for treatment scenes with obvious heat accumulation, such as larger targeted tissue size, longer treatment time and the like, and can reduce burning generated by ultrasonic heat effect by pulse emission at short intervals so as to optimize patient experience.
The communication unit 11 receives the treatment instruction transmitted from the host computer 10 and transmits it to the signal processing unit 12.
As an example, referring to fig. 3, the communication unit 11 mainly implements information interaction between the upper computer 1011 and the signal processing unit 12, when receiving a therapeutic instruction of the upper computer 10, the upper computer 10 first sends an instruction of an RS-232 signal, the 232-485 conversion module 110 converts the RS-232 signal into an RS-485 signal, then the first enhancement module 111 enhances the driving capability of the signal, the first isolation module 112 prevents mutual interference between the RS-485 signal and the RS-232 signal, and finally the 485 signal is converted into a UART signal receivable by the microcontroller 121 through the 485-UART conversion module 113, and then the UART signal is transmitted to the signal processing unit 12.
When the state is sent to the upper computer 10, the driving capability is enhanced by the second enhancing module 114, the interference is prevented by the second isolating module 115 circuit, the UART signal is converted into a 485 signal by the 485 and UART converting module 116, and finally the signal is converted into an RS-232 signal by the 232 and 485 converting module 110, and then the RS-232 signal is sent to the upper computer 10 for processing.
As one example, the enhancement modules (including the first enhancement module 111 and the second enhancement module 114) may specifically employ 74HC244, 74LVC16245, etc. line driver chips (ICs).
The signal processing unit 12 receives the therapeutic instruction sent from the communication unit 11, and performs decoding processing on the therapeutic instruction to generate a control signal. The control signals include an emission dose control signal, an emission frequency control signal, an emission time control signal, an interval time control signal, an emission region control signal, and an emission mode control signal. The signal processing unit 12 is configured with an original signal, and performs frequency division processing on the original signal under control of the transmission frequency control signal to obtain an original electric excitation signal. The original electrical excitation signal may be a square wave signal.
As an example, the decoding process for the therapeutic instruction specifically includes: defining a communication protocol between the upper computer 10 and the microcontroller 121, for example 0H (hexadecimal) represents a transmission dose of 0; C8H represents that the value of the dc power supply required for feeding the power switching element is 20V, and the corresponding emission dose of each integral emission dose is 0.1V; for example, 3FH represents that the preset transmitting area is all transmitting, 3EH is transmitting in I-VI area, 2EH is transmitting in I-1, II-1-VI-1, I-2, II-2-VI-2 area, 1EH is transmitting in I-1, II-1-VI-1 area, 11H is transmitting in I-1 area, 21H is transmitting in I-1, I-2 area, 12H is transmitting in I-2 area, etc., and the corresponding transmitting time, interval time, transmitting mode and transmitting frequency have corresponding codes representing the actual operating parameters. The upper computer 10 forms control instructions from the above various parameters through the corresponding coding modes, and transmits the control instructions to the microcontroller 121 through the communication interface, and after receiving the instructions, the microcontroller 121 analyzes the various parameters and executes different functional instructions, so as to complete corresponding control strategies and realize different functions.
The signal output unit 13 receives the control signal and the original electric excitation signal, and the signal output unit 13 amplifies the original electric excitation signal and sends it to the driving unit 14. And outputs the above signals to each driving unit 14. The number of the driving units 14 is equal to the number of the vibrating units 20, and one driving unit 14 drives one group of vibrating units 20.
The driving unit 14 receives the control signal and the original electric excitation signal enhanced by the signal output unit 13, so as to drive the spherical multi-chip array focusing ultrasonic transducer to work according to preset emission dosage, preset emission time, preset interval time, preset emission area, preset emission mode and preset emission frequency.
Compared with the prior art, the spherical focusing ultrasonic transducer control system provided by the invention has the advantages that the upper computer 10 is internally provided with the target tissue data, and the position and the focal domain size of the ultrasonic transducer are determined according to the position coordinates and the volume size, so that the focal domain is ensured to basically cover the target tissue. On this basis, the shot dose is further determined according to the depth from the epidermis. Based on this, the treatment effect is optimized while ensuring accurate treatment position, complete coverage of the treatment area, and proper treatment dosage.
In addition, the upper computer 10 generates a treatment instruction based on the target tissue data, which includes not only a dose treatment instruction, a frequency control instruction, but also a time control instruction, an interval time control instruction, an emission region control instruction, and an emission mode control instruction. On the basis of this, the signal processing unit 12 receives the above-described therapeutic instruction through the communication unit 11 to generate a control signal. Accordingly, the control signal transmits a dose control signal, a transmit frequency control signal, a transmit time control signal, an interval time control signal, a transmit region control signal, and a transmit mode control signal. Furthermore, the signal processing unit 12 is configured with an original frequency signal, and performs frequency division processing on the original frequency signal under the control of the transmission frequency control signal to obtain an original excitation signal suitable for the operation of the ultrasonic transducer. Based on this, the driving unit 14 drives the spherical multi-disc array type focused ultrasound transducer to operate not only in accordance with the preset emission dose and the preset emission frequency, but also in accordance with the preset emission time, the preset interval time, the preset emission region, and the preset emission mode.
The preset emission time is the continuous working time of the spherical multi-chip array type focusing ultrasonic transducer, and is positively correlated with the number of the disintegrated cancer cells, the heat generated in the targeted tissue and the periphery and negatively correlated with the service life of the treatment equipment under the condition that the preset emission dosage and the preset emission frequency are determined. In other words, the longer the preset emission time, the more the number of collapsed cancer cells, while generating and accumulating heat in and around the targeted tissue, and when the accumulated heat exceeds a certain threshold, there is a risk of burning healthy cells around the targeted tissue, and in addition, the longer the preset emission time, there is a risk of shortening the lifetime of the therapeutic device. The shorter the preset emission time is, the risk of incomplete collapse of the cancer cells exists. In view of the above, the present invention can effectively solve the foregoing technical problems by generating the preset emission time instruction according to the targeted tissue data, and further processing the preset emission time instruction into the preset emission time signal capable of controlling the operation of the spherical multi-chip array type focused ultrasound transducer.
The preset interval time is the time when the ultrasonic transducer is in pause operation, and in the preset interval time, heat in and around the target tissue can be effectively dissipated, so that the risk of burning healthy cells by heat exceeding a threshold value is reduced.
The preset transmitting area refers to an area formed by vibrating element units in a working state, the preset transmitting area influences the size and the position of a focal domain, and the size and the position of the focal domain are key parameters influencing the final treatment effect. The spherical multi-chip array type focusing ultrasonic transducer forms a preset transmitting area under the control of a transmitting area control signal, and at the moment, a focal domain with a preset size is generated at a preset position (can be the optimal position for treatment), so that the treatment effect is optimized.
The preset emission modes include a continuous mode and a pulse mode, and in practical application, the continuous mode or the pulse mode can be selected according to specific treatment requirements, and based on the continuous mode or the pulse mode, the applicability of the control system can be provided.
As a preferred implementation, the control system controls all vibrating element units to operate at the same frequency, the same phase and the same excitation voltage. The control is that the ultrasonic transducer outputs focal domain with definite position and size, and is suitable for the treatment of the target tissue with regular shape.
As a first alternative implementation, the control system controls all vibrating element units to operate at different frequencies, different phases and different excitation voltages.
As a second alternative implementation, the control system controls at least one vibrating element to operate at the same frequency, the same phase and the same excitation voltage, and the other vibrating element units do not operate.
When the control system executes any one of the two alternative implementation modes, the control system controls to realize the focal zone adjustment of the ultrasonic transducer. In practical application, when the shape of the target tissue is irregular or the position of the target tissue relative to the spherical multi-piece array focusing ultrasonic transducer is changed due to the position change of a patient in the treatment process, in order to adapt to the change of the relative positions of the irregular target tissue and the target tissue, all vibrating element units are controlled to work under different frequencies, different phases and different excitation voltages, or at least one vibrating element unit is controlled to work under the same frequencies, the same phases and the same excitation voltage, and other vibrating element units are not operated, so that focal domain is adjustable to adapt to different treatment requirements, thereby optimizing the treatment effect.
As one possible implementation, referring to fig. 4, the signal processing unit 12 includes a complex programmable logic device 120, a microcontroller 121, a frequency signal source 122, and a frequency synthesizer 123. The complex programmable logic device 120 receives the therapeutic instruction sent by the communication unit 11, and sends the therapeutic instruction to the microcontroller 121 after logic processing. After receiving the therapeutic instruction, the microcontroller 121 decodes the therapeutic instruction according to the decoding rules established by the upper computer 10 and the microcontroller 121 to convert the therapeutic instruction into an operable control signal. The transmission frequency control signal is sent to the frequency synthesizer 123, the frequency signal source 122 generates an original frequency signal and sends the original frequency signal to the frequency synthesizer 123, and the frequency synthesizer 123 performs frequency division processing on the original frequency signal under the control of the transmission frequency control signal so as to obtain an original electric excitation signal. The emission dose control signal, emission time control signal, interval time control signal, emission region control signal, and emission mode control signal are sent to the signal output unit 13.
As an example, complex programmable logic device 120 may be EPM7128, which forms a clock generation circuit with a passive crystal oscillator of 11.0592MHz, generates a clock source signal at a frequency of 11.0592MHz, and then generates the original electrical stimulus signal by frequency division by digital frequency synthesizer 123 under the control of microcontroller 121.
As a second example, the microcontroller 121 may be STM32F334 of an intentional semiconductor or an alternate version thereof, the microcontroller 121 being 32-bit-M4 core with FPU, performance sufficient to meet the requirements of signal decoding, control instruction processing, control signal encoding.
The AD9832 digital frequency synthesizer 123 used in this embodiment can realize frequency generation of 0.0025 Hz-11 MHz, which is enough to satisfy the frequency ranges of different vibrating element units and their combination forms. The treatment instruction is logically processed by adopting the complex programmable logic device 120, and the written software program is adopted to replace a hardware device, so that the treatment instruction treatment device has the advantages of simple structure and expandable function. In addition, the original excitation signal affecting the operating frequency of the ultrasonic transducer is obtained by generating an original frequency signal by the frequency signal source 122, the original frequency signal being received by the frequency synthesizer 123, and at the same time, the frequency synthesizer 123 performs frequency division processing on the original frequency signal under the control of the transmission frequency control signal to obtain an original electric excitation signal. The frequency synthesizer 123 is used for carrying out frequency division processing on the original frequency signal to obtain an original electric excitation signal, so that the precision of the original electric excitation signal can be ensured, and the precision of the working frequency of the ultrasonic transducer can be ensured.
In practice, the microcontroller 121 determines the frequency gating signal, the power gating signal, the digital potentiometer adjustment signal, and the frequency synthesizer control signal based on the therapy instructions. Wherein the frequency synthesizer control signal controls the frequency synthesizer 123, the frequency signal source 122 generates an original frequency signal, which may be, for example, an approximately square wave signal. The original frequency signal is subjected to frequency division processing under the control of the control signal of the frequency synthesizer 123 to obtain an original electric excitation signal. The original electrical excitation signal is further sent to a signal output unit 13 at the back end. The frequency synthesizer 123 is used for carrying out frequency division processing on the original frequency signal to obtain an original electric excitation signal, so that the precision of the original electric excitation signal can be ensured, and the precision of the working frequency of the ultrasonic transducer can be ensured.
The microcontroller 121 determines an emission region control signal, an emission time control signal, an interval time control signal, and an emission mode control signal based on its own generated frequency gate signal and power gate signal. The microcontroller 121 determines the emitted dose control signal based on its own generated digital potentiometer adjustment signal.
First, the microcontroller 121 generates four basic signals, namely, a frequency gating signal, a power gating signal, a digital potentiometer adjusting signal and an original electric excitation signal, according to a therapeutic instruction, and based on the four basic signals, the ultrasonic transducer can operate according to a preset emission dosage, a preset emission time, a preset interval time, a preset emission area, a preset emission mode and a preset emission frequency. Namely, the requirement of diversified control can be realized by utilizing four limited basic signals. In addition, the emission area control signal, the emission time control signal, the interval time control signal and the emission mode control signal are determined by utilizing the frequency gating signal and the power gating signal together, so that the method has the advantages of safety and reliability, namely, when any signal emission of the frequency gating signal and the power gating signal fails, whether the control signal exists or not can be realized by utilizing a failure-free signal.
As an example, each driving unit 14 drives one transducer unit, each transducer unit may be composed of 5 to 7 transducers, i.e. each sector contains a plurality of transducer units, one transducer contains 32 transducer units, and accordingly, one control system needs to configure 32 driving units 14. The above examples are intended to be illustrative only and not limiting.
As a possible implementation, referring to fig. 5, the driving unit 14 includes a driving circuit 140 and an output circuit 141. The driving circuit 140 includes a protection sub-circuit 1400, a logic sub-circuit 1401, and a gate sub-circuit 1402, a digital potentiometer 1403, and a power chip 1404. The output circuit 141 includes a resonant sub-circuit 1410 and an impedance transformation sub-circuit 1411. The preset emission frequency of the ultrasonic transducer is controlled by the following modes:
The protection sub-circuit 1400 receives the original electrical excitation signal and the frequency gating signal and performs anti-interference processing on the original electrical excitation signal and the frequency gating signal. The original electric excitation signal and the frequency gating signal after the anti-interference processing are sent to a logic sub-circuit 1401, and after the logic processing, are sent to a harmonic oscillator circuit 1410.
The gating sub-circuit 1402 receives the serial power gating signal and the digital potentiometer adjustment signal, converts the serial power gating signal and the digital potentiometer adjustment signal into parallel signals, and then sends the parallel signals to the anti-interference processing of the protection sub-circuit 1400, and selects the power chip 1404 and the digital potentiometer 1403 according to the power gating signal and the digital potentiometer adjustment signal. The power chip 1404 generates a dc voltage, and the digital potentiometer 1403 is used for controlling the magnitude of the dc voltage. The dc voltage of the preset magnitude is sent to the resonant subcircuit 1410.
The dc voltage is sent to the resonator circuit 1410, is chopper-processed by the resonator circuit 1410 and forms a sine wave by the impedance transformation sub-circuit 1411, which is used to drive the vibrating element unit so that the vibrating element unit emits ultrasonic waves according to a preset emission dose.
The logic sub-circuit 1401 receives and processes the frequency gating signal and the original electric excitation signal, outputs a synchronous electric excitation signal, sends the synchronous electric excitation signal to the resonant sub-circuit 1410, and controls the resonant sub-circuit 1410 to be turned on/off according to the operating frequency of the vibrating element unit 20 so that the vibrating element unit emits ultrasonic waves according to a preset emission frequency. The impedance transformation sub-circuit 1411 is used for performing impedance matching on the vibrating element unit so that the vibrating element unit emits ultrasonic waves according to a preset emission frequency.
So configured, the original electrical excitation signal, the power gating signal via the gating sub-circuit 1402, the frequency gating signal, and the digital potentiometer adjustment signal are isolated and filtered by the protection sub-circuit 1400, and then subjected to anti-interference processing to reduce the adverse effects of the interference signal on the signals, thereby improving the accuracy of the preset transmission frequency finally output to the ultrasonic transducer.
Since the control signal and the driving unit 14 are in one-to-many relation, the control signal needs to encode the control instruction of each driving unit, corresponding to different vibrating element unit groups, define different driving module IDs, take a total of 100 paths as an example, want to control 10 th ultrasonic emission, define ID001 to represent the first vibrating element unit group, ID100 to represent the 100 th vibrating element unit group, the control signals output by the microcontroller 121 are distinguished by control types (emission time, interval time, emission frequency, emission dosage, etc.), the signals of each control type are arranged according to the ID sequence, the encoding signals from ID001 to the last ID are transmitted, on each driving module, the chip responsible for decoding receives all signals from ID001 to ID100 in series, extracts ID010 path control signals belonging to own ID, and respectively transmits the control signals to controlled elements (digital potentiometer 1403, power chip 1404 enable, etc.) of different control types, so as to complete the respective control of each path.
As an example, the digital potentiometer 1403 is of an 8-bit high withstand voltage model, and when the digital potentiometer 1403 is specifically used, the control values 0H to FFH of the digital potentiometer 1403 correspond to 0V to 25.5V of the dc power supply required for feeding the power switching element, so as to realize adjustment of emission dose.
As a second example, the power chip 1404 may employ an integrated resistance value feedback dc-dc converter. Feedback is provided to the power chip 1404 to achieve 0-25.5V voltage control by adjusting the resistance of the digital potentiometer 1403 described above. Under the condition of adopting the technical scheme, the digital potentiometer 1403 and the power chip 1404 jointly form a power supply, and the power supply has the advantage of reliable output power. In addition, the digital potentiometer 1403 can also achieve the purpose of fine output.
As a possible implementation, the microcontroller 121 determines a plurality of treatment cycles according to the treatment instructions, with the drive unit 14 alternately being gated or not being gated within each treatment cycle, based on which a preset emission time and a preset interval time between two adjacent preset emission times are determined. The microcontroller 121 transmits the power gating signal and the digital potentiometer control signal to the driving unit 14 through the signal output unit 13 for a preset transmission time. The microcontroller 121 sends the frequency gating signal and the frequency synthesizer sends the original electrical excitation signal to the driving unit 14 via the signal output unit 13. Based on the above, the spherical focusing ultrasonic transducer transmits ultrasonic waves according to a preset transmission dosage and a preset transmission frequency in a preset transmission time.
As a possible implementation, the microcontroller 121 terminates the transmission of the power-on signal and the digital potentiometer control signal to the driving unit 14 through the signal output unit 13 for a preset interval. The microcontroller 121 terminates the transmission of the frequency gating signal and the frequency synthesizer 123 terminates the transmission of the original electrical excitation signal to the driving unit 14 through the signal output unit 13. Based on the above, the spherical focusing ultrasonic transducer stops transmitting ultrasonic waves according to the preset transmitting dose and the preset transmitting frequency within the preset interval time.
As a possible implementation, the microcontroller 121 determines the number and positions of the strobes in the M/N vibrating element units based on the therapy instructions, based on which the microcontroller 121 sends the power gating signal, the digital potentiometer control signal, the frequency gating signal, and the frequency synthesizer sends the original electrical excitation signal to the driving unit 14 to be strobed through the signal output unit 13 to cause the spherically focused ultrasound transducer to emit ultrasound according to the preset emission region.
As a possible implementation manner, the microcontroller 121 receives an emission mode control instruction included in the therapeutic instruction to generate an emission mode control signal, where the emission mode control signal is an enable signal, and the enable signal is sent to the complex programmable logic device 120 to control a logic circuit therein to logically process the original frequency signal generated by the frequency signal source 122, so as to generate a continuous mode or a pulse mode on the original frequency signal, and control the spherical focusing ultrasonic transducer to emit ultrasonic waves according to a preset emission mode.
It should be further explained that each unit is configured with a power module 15, and mainly supplies power to each chip device in the circuit, and the electrical parameters of the devices used in the circuit are designed and calculated to obtain the electrical requirement of the circuit overall, and the power modules 15 of the control unit and the driving unit 14 are determined by the type of the power chip 1404.
As a possible implementation, the control system controls all vibrating element units to work at the same frequency, the same phase and the same excitation voltage. Or the control system controls all vibrating units to work at different frequencies, different phases and different excitation voltages. Or the control system controls at least one vibrating element unit to work under the same frequency, the same phase and the same excitation voltage, and other groups of vibrating element units do not work. The control is executed to realize the focus area adjustability of the spherical multi-piece array type focusing ultrasonic transducer.
Under the condition of adopting the technical scheme, when all vibrating element units work under the same frequency, the same phase and the same excitation voltage, the spherical multi-disc array type focusing ultrasonic transducer outputs focal areas with determined positions and sizes, and is suitable for the treatment of the target tissues with regular shapes. When the shape of the target tissue is irregular or the position of the target tissue relative to the spherical multi-piece array focusing ultrasonic transducer is changed due to the position change of a patient in the treatment process, in order to adapt to the change of the relative positions of the irregular target tissue and the target tissue, the focus area is adjustable by controlling all vibrating element units to work under different frequencies, different phases and different excitation voltages or controlling at least one group of vibrating element units to work under the same frequencies, the same phases and the same excitation voltage, and other groups of vibrating element units not to work so as to adapt to different treatment requirements, thereby optimizing the treatment effect. The embodiment of the invention also comprises an auxiliary positioning device, wherein the auxiliary positioning device comprises: laser marking device and B ultrasonic probe. The laser marking device consists of four paths of symmetrically distributed laser emitting devices. Four paths of laser are converged at the ultrasonic focal domain position and used for marking the actual position of the ultrasonic focal domain. The B ultrasonic probe is used for monitoring the treatment process in real time.
In a second aspect, the present invention further provides a control method of a spherical focusing ultrasonic transducer, the control method being performed by the control system provided in the first aspect, the control method comprising:
and the upper computer is internally provided with targeted tissue data, and the targeted tissue data comprises position coordinates, volume and depth from epidermis. Treatment instructions are generated based on the targeted tissue data.
The communication unit receives the treatment instruction sent by the upper computer and sends the treatment instruction to the signal processing unit.
The complex programmable logic device of the signal processing unit receives the treatment instruction sent by the communication unit, carries out logic processing on the treatment instruction and then sends the treatment instruction to the microcontroller, and the microcontroller carries out decoding processing on the treatment instruction to generate a frequency gating signal, a power gating signal, a digital potentiometer control signal and a frequency synthesizer control signal. The frequency signal source generates an original signal with basic frequency, the original signal is sent to the frequency synthesizer, the frequency synthesizer simultaneously receives a frequency synthesizer control signal sent by the microcontroller to carry out frequency division processing on the original signal to obtain an original electric excitation signal, and the original electric excitation signal, the power gating signal, the digital potentiometer control signal and the frequency gating signal are controllably sent to at least one of M/N driving units through the signal output unit.
When the driving unit receives the signals, the gating sub-circuit receives and adjusts the serial power gating signals and the digital potentiometer control signals into parallel signals, then sends the power gating signals to the power chip, and sends the digital potentiometer control signals to the digital potentiometer to generate direct-current voltage. The direct-current voltage is sent to the harmonic oscillator circuit, is subjected to chopper processing by the harmonic oscillator circuit and forms a sine wave by the impedance transformation sub circuit, and the sine wave is used for driving the vibrator unit so that the vibrator unit emits ultrasonic waves according to a preset emission dose.
The logic sub-circuit receives and processes the frequency gating signal and the original electric excitation signal, outputs a synchronous electric excitation signal, sends the synchronous electric excitation signal to the harmonic oscillator circuit, and controls the harmonic oscillator circuit to be switched on/off according to the working frequency of the vibrator unit so that the vibrator unit emits ultrasonic waves according to the preset emission frequency. The impedance transformation sub-circuit is used for carrying out impedance matching on the vibrating element unit so that the vibrating element unit emits ultrasonic waves according to a preset emission frequency.
As one possible implementation, the original electric excitation signal, the power gating signal, the digital potentiometer control signal and the frequency gating signal are controllably transmitted to at least one of the M/N driving units via the signal output unit, including:
The microcontroller generates an emission area control signal based on the treatment instruction, and determines the number and positions of the strobes in the M/N vibrating element units based on the emission area control signal. Based on the above, the microcontroller transmits the power gating signal, the digital potentiometer control signal, the frequency gating signal and the frequency synthesizer to the driving unit to be gated through the signal output unit, so that the spherical focusing ultrasonic transducer transmits ultrasonic waves according to a preset transmitting area.
The microcontroller determines a plurality of treatment periods based on the treatment instructions, and the spherical focusing ultrasonic transducer alternately emits and stops in each treatment period, and based on the treatment periods, the preset emission time and the preset interval time between two adjacent preset emission times are determined. And in the preset transmitting time, the microcontroller transmits the power gating signal and the digital potentiometer control signal to the driving unit through the signal output unit. The microcontroller transmits the frequency gating signal and the frequency synthesizer transmits the original electrical excitation signal to the driving unit through the signal output unit. Based on this, the spherical focusing ultrasonic transducer transmits ultrasonic waves within a preset transmission time. And in the preset interval time, the microcontroller stops sending the power gating signal and the digital potentiometer control signal to the driving unit through the signal output unit. The microcontroller terminates the transmission of the frequency gating signal and the frequency synthesizer terminates the transmission of the original electrical excitation signal to the drive unit via the signal output unit. Based on this, the spherical focusing ultrasonic transducer terminates the emission of ultrasonic waves for a preset interval time.
The microcontroller receives the emission mode control instruction to generate an emission mode control signal, the emission mode control signal is an enabling signal, the enabling signal is sent to the complex programmable logic device, and the logic circuit in the microcontroller is controlled to logically process an original frequency signal generated by the frequency signal source so as to enable the original frequency signal to generate a continuous mode or a pulse mode, so that control of the emission mode is realized.
Under the condition that the preset transmitting area, the preset transmitting time, the preset interval time and the transmitting mode are determined, the spherical focusing ultrasonic transducer is controlled to transmit ultrasonic waves according to the preset transmitting frequency and the preset transmitting dosage according to the control method provided by the second aspect.
In a third aspect, the present invention also provides a terminal comprising a processor and a communication interface coupled to the processor; the processor is configured to execute a computer program or instructions to implement the spherical focusing ultrasound transducer control method according to the second aspect.
In a fourth aspect, the present invention further provides a therapeutic apparatus, which performs the spherical focusing ultrasound transducer control method according to the second aspect, or which applies the spherical focusing ultrasound transducer control system according to the first aspect.
Compared with the prior art, the invention has the following technical effects:
First, using the targeted tissue data (position coordinates, volume and depth from the epidermis) a treatment order can be determined from which the control signals ultimately used to control the transducer to emit ultrasound are determined. In order to optimize the therapeutic effect and the patient experience, under the control of the control signal, the transducer may work according to preset parameters, and the preset parameters may specifically include a preset emission area, a preset emission time, a preset interval time, a preset emission mode, a preset emission dose, and a preset emission frequency to emit ultrasonic waves. The preset parameters can be determined by four basic parameters, namely, four basic parameters of an original electric excitation signal, a power gating signal, a digital potentiometer control signal and a frequency gating signal. Based on the above, the control system can meet diversified application requirements by adopting simpler logic control, not only can simplify the structure of the control system and reduce the cost, but also can improve the applicability of the control system and the treatment equipment and optimize the treatment effect.
Second, the power chip generates direct current voltage under the control of the power gating signal, the digital potentiometer adjusts the resistance value of the digital potentiometer under the control of the digital potentiometer control signal, and then the direct current voltage is adjusted, the direct current voltage is chopped by the harmonic oscillator circuit to form an approximate sine wave, the approximate sine wave is converted into a sine wave by the impedance conversion sub-circuit, and the voltage with the sine wave is the excitation voltage of the transducer, namely the preset emission dose. The digital potentiometer, the power chip, the harmonic oscillator circuit and the impedance transformation sub-circuit are matched to generate sine waves, so that the sine waves can be conveniently adjusted according to actual treatment requirements (the sine waves can be realized by adjusting the resistance value of the digital potentiometer), and the sine waves have the advantage of high adjustment precision.
Thirdly, the signal processing unit and the driving unit can adopt simpler devices to realize diversified functions, so that the cost can be reduced, and the drift and loss in the signal transmission process can be reduced, thereby improving the control precision.
Although the invention is described herein in connection with various embodiments, other variations to the disclosed embodiments can be understood and effected by those skilled in the art in practicing the claimed invention, from a study of the drawings, the disclosure, and the appended claims. In the claims, the word "comprising" does not exclude other elements or steps, and the "a" or "an" does not exclude a plurality. A single processor or other unit may fulfill the functions of several items recited in the claims. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage.
Although the invention has been described in connection with specific features and embodiments thereof, it will be apparent that various modifications and combinations can be made without departing from the spirit and scope of the invention. Accordingly, the specification and drawings are merely exemplary illustrations of the present invention as defined in the appended claims and are considered to cover any and all modifications, variations, combinations, or equivalents that fall within the scope of the invention. It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (10)
1. The spherical focusing ultrasonic transducer control system is characterized in that the spherical focusing ultrasonic transducer is a spherical multi-piece array focusing ultrasonic transducer, M piezoelectric vibrating elements are configured, N of the M piezoelectric vibrating elements are in a group, M/N vibrating element units are formed in total, and N piezoelectric vibrating elements in the same vibrating element unit are connected in parallel, in series or in series-parallel; the control system comprises an upper computer, a communication unit, a signal processing unit, a signal output unit and a driving unit; M/N driving units, namely one driving unit is correspondingly configured for one vibrating unit;
The upper computer is internally provided with targeted tissue data, wherein the targeted tissue data comprises position coordinates, volume and depth from epidermis; generating a treatment instruction based on the targeted tissue data;
The communication unit receives the treatment instruction sent by the upper computer and sends the treatment instruction to the signal processing unit;
The signal processing unit comprises a complex programmable logic device, a microcontroller, a frequency signal source and a frequency synthesizer; the complex programmable logic device receives the treatment instruction, carries out logic processing on the treatment instruction and then sends the treatment instruction to the microcontroller; the microcontroller receives the treatment instruction and generates a frequency gating signal, a power gating signal, a digital potentiometer control signal and a frequency synthesizer control signal based on the treatment instruction; the frequency signal source generates an original signal with basic frequency, the original signal is sent to the frequency synthesizer, the frequency synthesizer simultaneously receives a frequency synthesizer control signal sent by the microcontroller so as to carry out frequency division processing on the original signal to obtain an original electric excitation signal, and the original electric excitation signal, a power gating signal, a digital potentiometer control signal and the frequency gating signal are sent to at least one of M/N driving units through the signal output unit;
Each driving unit comprises a driving circuit and an output circuit; the driving circuit comprises a gating sub-circuit, a digital potentiometer, a power chip and a logic sub-circuit; the output circuit comprises a harmonic oscillator circuit and an impedance transformation circuit; the gating sub-circuit receives the serial power gating signal and the digital potentiometer control signal and adjusts the serial power gating signal and the digital potentiometer control signal into parallel signals, then sends the power gating signal to a power chip, and sends the digital potentiometer control signal to a digital potentiometer to generate direct-current voltage; the direct-current voltage is sent to the harmonic oscillator circuit, is subjected to chopping treatment by the harmonic oscillator circuit and forms a sine wave by the impedance transformation sub circuit, and the sine wave is used for driving the vibrating element unit so that the vibrating element unit emits ultrasonic waves according to a preset emission dose;
The logic sub-circuit receives and processes the frequency gating signal and the original electric excitation signal, outputs a synchronous electric excitation signal and sends the synchronous electric excitation signal to the harmonic oscillator circuit, and controls the harmonic oscillator circuit to be switched on/off according to the working frequency of the vibrator unit so that the vibrator unit emits ultrasonic waves according to a preset emission frequency; the impedance transformation sub-circuit is used for carrying out impedance matching on the vibrating element unit so that the vibrating element unit emits ultrasonic waves according to the preset emission frequency.
2. The spherical focusing ultrasound transducer control system according to claim 1, wherein the microcontroller determines a plurality of treatment cycles according to the treatment instructions, the driving unit alternately being gated or not being gated in each of the treatment cycles, based on which a preset emission time and a preset interval time between two adjacent preset emission times are determined;
in the preset emission time, the microcontroller sends the power gating signal and a digital potentiometer control signal to the driving unit through the signal output unit; the microcontroller sends the frequency gating signal and the frequency synthesizer sends an original electric excitation signal to the driving unit through the signal output unit; based on the above, the spherical focusing ultrasonic transducer transmits ultrasonic waves according to a preset transmission dosage and a preset transmission frequency in the preset transmission time.
3. The spherical focusing ultrasonic transducer control system according to claim 2, wherein the microcontroller terminates transmission of the power gating signal and the digital potentiometer control signal to the driving unit through the signal output unit during the preset interval time; the microcontroller terminating the transmission of the frequency gating signal and the frequency synthesizer terminating the transmission of the original electrical excitation signal to the drive unit via the signal output unit; based on the above, the spherical focusing ultrasonic transducer stops transmitting ultrasonic waves according to the preset transmitting dose and the preset transmitting frequency within the preset interval time.
4. The spherical focusing ultrasonic transducer control system according to claim 1, wherein the microcontroller determines the number and positions of the strobes in the M/N number of the vibrating cells based on the treatment instruction, based on which the microcontroller transmits the power gating signal, the digital potentiometer control signal, the frequency gating signal, and the frequency synthesizer transmits an original electric excitation signal to the driving unit to be strobed through the signal output unit to cause the spherical focusing ultrasonic transducer to emit ultrasonic waves according to a preset emission region.
5. The spherical focusing ultrasonic transducer control system according to claim 1, wherein the microcontroller receives an emission mode control instruction included in the therapeutic instruction to generate an emission mode control signal, the emission mode control signal is an enable signal, the enable signal is sent to the complex programmable logic device, and a logic circuit in the complex programmable logic device is controlled to logically process the original signal generated by the frequency signal source so as to enable the original signal to generate a continuous mode or a pulse mode, and the spherical focusing ultrasonic transducer is controlled to emit ultrasonic waves according to a preset emission mode.
6. The spherical focusing ultrasonic transducer control system according to claim 1, wherein the control system controls all the vibrating element units to work at the same frequency, the same phase and the same excitation voltage; or the control system controls all the vibrating element units to work under different frequencies, different phases and different excitation voltages; or the control system controls at least one vibrating element unit to work under the same frequency, the same phase and the same excitation voltage, and other groups of vibrating element units do not work; the control is executed to realize the focal zone adjustability of the spherical multi-piece array focusing ultrasonic transducer.
7. A spherical focusing ultrasonic transducer control method, characterized in that the control method is performed by the control system of claim 5, the control method comprising:
Configuring targeted tissue data in an upper computer, wherein the targeted tissue data comprises position coordinates, volume and depth from epidermis; generating a treatment instruction based on the targeted tissue data;
the communication unit receives the treatment instruction sent by the upper computer and sends the treatment instruction to the signal processing unit;
The complex programmable logic device of the signal processing unit receives the treatment instruction sent by the communication unit, carries out logic processing on the treatment instruction and then sends the treatment instruction to the microcontroller, and the microcontroller carries out decoding processing on the treatment instruction to generate a frequency gating signal, a power gating signal, a digital potentiometer control signal and a frequency synthesizer control signal; the frequency signal source generates an original signal with basic frequency, the original signal is sent to the frequency synthesizer, the frequency synthesizer simultaneously receives a frequency synthesizer control signal sent by the microcontroller so as to carry out frequency division processing on the original signal to obtain an original electric excitation signal, and the original electric excitation signal, a power gating signal, a digital potentiometer control signal and the frequency gating signal are controllably sent to at least one of M/N driving units through the signal output unit;
when the driving unit receives the signals, the gating sub-circuit receives the serial power gating signals and digital potentiometer control signals and adjusts the serial power gating signals and the digital potentiometer control signals into parallel signals, then the power gating signals are sent to a power chip, and the digital potentiometer control signals are sent to a digital potentiometer to generate direct-current voltage; the direct-current voltage is sent to the harmonic oscillator circuit, is subjected to chopping treatment by the harmonic oscillator circuit and forms a sine wave by the impedance transformation sub circuit, and the sine wave is used for driving the vibrating element unit so that the vibrating element unit emits ultrasonic waves according to a preset emission dose;
The logic sub-circuit receives and processes the frequency gating signal and the original electric excitation signal, outputs a synchronous electric excitation signal, and sends the synchronous electric excitation signal to the harmonic oscillator circuit, and controls the harmonic oscillator circuit to be switched on/off according to the working frequency of the vibrator unit so that the vibrator unit emits ultrasonic waves according to a preset emission frequency; the impedance transformation sub-circuit is used for carrying out impedance matching on the vibrating element unit so that the vibrating element unit emits ultrasonic waves according to the preset emission frequency.
8. The method of claim 7, wherein the raw electrical excitation signal, the power gating signal, the digital potentiometer control signal, and the frequency gating signal are controllably transmitted to at least one of the M/N driving units via the signal output unit, comprising:
The microcontroller generates an emission area control signal based on the treatment instruction, and determines the number and the positions of the strobes in the M/N vibrating element units based on the emission area control signal; based on the above, the microcontroller sends the power gating signal, the digital potentiometer control signal, the frequency gating signal and the frequency synthesizer to the driving unit to be gated through the signal output unit so that the spherical focusing ultrasonic transducer emits ultrasonic waves according to a preset emission area;
The microcontroller determines a plurality of treatment periods based on the treatment instructions, wherein the spherical focusing ultrasonic transducer alternately emits and stops in each treatment period, and based on the treatment periods, the preset emission time and the preset interval time between two adjacent preset emission times are determined; in the preset emission time, the microcontroller sends the power gating signal and a digital potentiometer control signal to the driving unit through the signal output unit; the microcontroller sends the frequency gating signal and the frequency synthesizer sends the original electric excitation signal to the driving unit through the signal output unit; based on the above, the spherical focusing ultrasonic transducer transmits ultrasonic waves within the preset transmission time; the microcontroller terminates sending the power gating signal and the digital potentiometer control signal to the driving unit through the signal output unit within the preset interval time; the microcontroller terminating the transmission of the frequency gating signal and the frequency synthesizer terminating the transmission of the original electrical excitation signal to the drive unit via the signal output unit; based on this, the spherical focusing ultrasonic transducer terminates transmitting ultrasonic waves within the preset interval time;
The microcontroller receives the emission mode control instruction to generate an emission mode control signal, wherein the emission mode control signal is an enabling signal, the enabling signal is sent to the complex programmable logic device, and a logic circuit in the microcontroller is controlled to logically process an original frequency signal generated by the frequency signal source so as to enable the original frequency signal to generate a continuous mode or a pulse mode, so that control of the emission mode is realized;
In the case that the preset transmitting area, the preset transmitting time, the preset interval time and the transmitting mode are determined, the spherical focusing ultrasonic transducer is controlled to transmit ultrasonic waves according to the preset transmitting frequency and the preset transmitting dosage according to the control method of claim 7.
9. A terminal comprising a processor and a communication interface coupled to the processor; the processor is configured to execute a computer program or instructions to implement the spherical focusing ultrasound transducer control method of claim 7 or 8.
10. A therapeutic apparatus, characterized in that it performs the spherical focusing ultrasound transducer control method according to claim 7 or 8, or that it applies the spherical focusing ultrasound transducer control system according to any one of claims 1 to 6.
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