CN115281895A - Valve clip control handle, delivery device and valve repair system - Google Patents

Abstract

The invention relates to a valve clamp control handle, a delivery device and a valve repair system. The valve clamp control handle comprises a casing, an actuating wire and an actuating wire control mechanism. The actuating wire is partially located in the casing, and the distal end of the actuating wire is located in the casing. It can be threadedly connected with the valve clamp through the sheath tube. The actuating wire control mechanism includes a pressing wire assembly, a driving knob and an unloading knob. The pressing wire assembly is slidably arranged in the housing and is connected with the actuating wire. In the first working condition, it can move synchronously with the actuating wire; the drive knob abuts the proximal end of the wire pressing assembly and is threadedly connected with the housing, and the driving knob can push the pressing wire assembly and the actuating wire to move to drive the clamping arm Open and close; the unloading knob abuts the proximal end of the driving knob and is connected with the actuating wire, the unloading knob is set to be able to move synchronously with the actuating wire under the first working condition, and can drive the actuating wire to rotate under the second working condition In order to be disengaged from the valve clamp, the valve clamp control handle proposed by the present invention has a compact structure and is easy to operate.

Description

Valve clip control handle, delivery device and valve repair system

technical field

The invention belongs to the technical field of medical devices, and in particular relates to a valve clip control handle, a delivery device and a valve repair system.

Background technique

Heart valve refers to the valve between the atrium and the ventricle or between the ventricle and the artery. The atrioventricular valve includes the mitral valve and the tricuspid valve. The mitral valve is two valves attached to the periphery of the left atrioventricular orifice and connected to the nipple by the tendon Mitral valve regurgitation is a poor anastomosis of the anterior and posterior leaflets of the mitral valve caused by organic or functional changes in the mitral valve leaflets and related structures. During valve regurgitation, the blood flow will flow back from the left ventricle to the left atrium, causing a series of pathophysiological changes.

Surgical valve repair or replacement is considered to be the standard treatment for this type of disease. However, surgery has the disadvantages of large trauma, obvious postoperative pain, slow recovery, and high risk. In recent years, interventional therapy for heart valve disease has The advantages of small trauma, relatively safe, and good curative effect have led to rapid development. Among them, the valve repair method developed based on the principle of surgical valve edge-to-edge suture technology has been affirmed due to its high safety, simple technical principle, and high feasibility. During the process, the operator needs to use the delivery device to deliver the valve clamp to the patient. The valve clamp control handle in the delivery device is used to control the valve clamp. However, the structure of the valve clamp control handle in the related art is complex and the operation steps are cumbersome. affect surgical efficiency.

Contents of the invention

The purpose of the present invention is to at least solve the problem of cumbersome operation steps of the valve clip control handle. This purpose is achieved through the following technical solutions:

The first aspect of the present invention provides a valve clamp control handle for controlling a valve clamp, the valve clamp includes a plurality of relatively open and closed clamp arms, the valve clamp control handle includes a housing, an actuator A wire and an actuating wire control mechanism, the actuating wire part is located in the housing, the distal end of the actuating wire can be threadedly connected with the valve clamp through the sheath tube, the actuating wire control mechanism It includes a wire pressing assembly, a driving knob and an unloading knob, the wire pressing assembly is slidably arranged in the housing and connected with the actuating wire, and the wire pressing assembly is configured to be able to be connected with the The actuating wire moves synchronously; the driving knob abuts against the proximal end of the pressing wire assembly and is threadedly connected with the housing, and the driving knob can push the pressing wire assembly and the actuating wire to move , so as to drive the clamp arm to open and close; the unloading knob abuts against the proximal end of the driving knob and is connected with the actuating wire, and the unloading knob is set to be able to be connected with the The actuating wire moves synchronously, and in the second working condition, it can drive the actuating wire to rotate to disengage from the valve clamp.

In the valve clamp control handle proposed by the embodiment of the present invention, the wire pressing assembly, the driving knob, and the unloading knob cooperate with each other and can be linked in the first working condition. The operator only needs to turn the driving knob to control the movement of the actuating wire. Then, the clamp arm in the valve clamp can realize the opening and closing action; after adjusting the pressing wire assembly to the second working condition, the operator only needs to turn the unloading knob to control the rotation of the actuating wire, and then make the actuating wire and the valve The clamp realizes dissociation without the need for external tools to control the actuating wire. In this embodiment, the actuating wire control mechanism has a high degree of functional integration, which makes the control handle of the valve clip not only compact in structure, but also easy to operate, solving the problem of the control handle of the valve clip. The problem of cumbersome operation steps improves the operation efficiency.

In addition, the valve clip control handle proposed according to the embodiment of the present invention may also have the following technical features:

In some embodiments of the present invention, the thread pressing assembly includes a thread pressing column and a limiting block, the actuating wire is passed through the thread pressing column, and the limiting block is detachably connected to the On the thread pressing column, and at least partially located on the proximal side of the thread pressing column, the limiting block can prevent the thread pressing column from rotating under the working condition of being connected with the thread pressing column.

In some embodiments of the present invention, the wire pressing assembly further includes a thumb screw, the thumb screw is inserted into the limit block and detachably connected with the wire pressing post, and the thumb screw The end portion is exposed outside the housing.

In some embodiments of the present invention, the actuating wire control mechanism further includes a wire tube, the wire tube extends from the inside of the thread pressing column toward the distal end, and can be passed into the sheath, The actuating wire is partly passed through the harness tube.

In some embodiments of the present invention, the thread pressing column is provided with a first through hole in the axial direction, and at least one first locking hole communicated with the first through hole is provided in the radial direction, and the first The locking hole is used for installing a fastener to lock the actuating wire and/or the harness tube located in the first through hole.

In some embodiments of the present invention, the valve clip control handle further includes bearings, and the driving knob and the unloading knob are respectively matched with the bearings.

In some embodiments of the present invention, the driving knob includes a threaded rod connected with a rotating head, the bearing is arranged in the rotating head, and the unloading knob is partially inserted in the rotating head and connected to the rotating head. Compatible with the above bearings.

In some embodiments of the present invention, the unloading knob is provided with a second through hole in the axial direction, and one or more second locking holes are provided in the radial direction, and the second locking holes are used for installation and fastening A component is used to lock the actuating wire located in the second through hole.

The second aspect of the present invention provides a delivery device, which includes a sheath tube, an adjustable curved sheath, a sheath tube bending handle, and a valve clip control handle according to any of the above-mentioned embodiments. The adjustable curved sheath It is connected with the sheath tube bending handle, the sheath tube is movably installed in the adjustable curved sheath, and the proximal end of the sheath tube is connected in the valve clip control handle.

The delivery device proposed in the embodiment of the present invention has the same advantages as the valve clip control handle proposed in any of the above embodiments, and will not be repeated here.

The third aspect of the present invention provides a valve repair system, the valve repair system includes a valve clamp and the delivery device according to any of the above embodiments, the sheath of the delivery device and the valve clamp can be The connection is disassembled to deliver the valve clip.

The valve repair system proposed by the embodiment of the present invention has the same advantages as the valve clamp control handle and the delivery device proposed by any of the above embodiments, and will not be repeated here.

Description of drawings

The following is a brief introduction to the accompanying drawings in the implementation manner. Those skilled in the art can also obtain other drawings according to these drawings without making creative efforts.

FIG. 1 is a schematic structural view of a valve repair system;

Figure 2 is a schematic structural view of the valve clamp in the valve repair system;

Fig. 3 is a kind of structure schematic diagram of valve clip control handle;

Fig. 4 is a schematic diagram of the internal structure of the valve clip control handle;

Figure 5 is a top view of Figure 4;

Figure 6 is an exploded view of the actuating wire control mechanism in the control handle of the valve clip;

Figure 7 is an exploded view of the puller wire control mechanism in the valve clip control handle;

Figure 8 is a partial exploded view of the valve clip control handle;

Fig. 9 is a schematic diagram of valve clip control handle controlling the opening of the clip arm and the opening of the catching arm of the valve clip;

Fig. 10 is a schematic diagram of valve clamp control handle controlling clamp arm closing and capture arm capture of valve clamp;

Fig. 11 is a schematic diagram when the control handle of the valve clamp is disengaged from the valve clamp.

Detailed ways

The following will be combined with the accompanying drawings in the embodiments of the present invention. The terms used herein are only for the purpose of describing specific exemplary embodiments, and cannot be construed as limiting the present invention. For example, the terms "comprising" and "having" not only indicate the existence of the The features of the above-mentioned features are not excluded, and the existence of other features is not excluded; the terms "first", "second" do not imply a sequence or order; The relationship of one feature shown relative to another is not intended to imply that it must have a particular orientation. It should be noted that in the field of interventional medical devices, the proximal end refers to the end closer to the operator, and the distal end refers to the end farther from the operator; the axial direction refers to the center of the distal end of the medical device parallel to the natural state. In the description of the present invention, the direction of the line connecting with the center of the proximal end, the above definition is only for the convenience of expression, and should not be construed as a limitation of the present invention.

Referring to Fig. 1 to Fig. 5, the embodiment of the first aspect of the present invention proposes a valve clamp control handle 100, and the embodiment of the second aspect of the present invention proposes a delivery device 1100, which can be applied to this The embodiment of the third aspect of the invention proposes a valve repair system 1000, as shown in FIG. 1 , in the valve repair system 1000, a delivery device 1100 is used to send a valve clamp 1200 into the patient's body, for example, through a minimally invasive entrance on the body surface And the blood vessels are delivered to the designated position to realize the repair treatment of heart valves (including but not limited to mitral valve, tricuspid valve, aortic valve, pulmonary valve). The valve clamp control handle 100 in the delivery device 1100 is used to control the action of the valve clamp 1200 , such as capturing and clamping.

Exemplarily, referring to FIG. 2 , a valve clamp 1200 includes a sliding member 1203, a plurality of oppositely opened and closed clamping arms 1201 and a plurality of capturing arms 1202. When the sliding member 1203 slides in the axial direction, it is directly connected or The clamping arm 1201 indirectly connected through the intermediate structure rotates to open or close, thereby clamping the valve. For example, when the valve clamp 1200 is applied to mitral valve repair, the number of clamping arms 1201 and catching arms 1202 can be set to two, the two catching arms 1202 are used to capture the valve, and the two clamping arms 1201 are used to clamp close the captured valve, thereby realizing mitral valve edge-to-edge repair. On this basis, the valve clamp control handle 100 proposed in this embodiment is connected with the valve clamp 1200 through the sheath tube 1130, and the valve clamp 1200 is connected At the distal end of the sheath tube 1130 , the valve clip control handle 100 is connected to the proximal end of the sheath tube 1130 .

Please continue to refer to Fig. 1, Fig. 2 to Fig. 5, and refer to Fig. 6 to Fig. 8 in conjunction with Fig. The wire 40 and the pulling wire control mechanism 50, the distal end of the housing 10 is provided with a sheath channel 11 matched with the sheath 1130; the actuation wire 20 is movably arranged in the housing 10 along the axial direction, and the actuation wire The distal end of 20 can pass through the sheath tube 1130 and be threadedly connected with the valve clamp 1200; the actuating wire control mechanism 30 is connected with the actuating wire 20, and the actuating wire control mechanism 30 is set to drive the actuating wire under one working condition 20 moves to make the clip arm 1201 open and close, and drives the actuating wire 20 to rotate in another working condition to disengage from the valve clamp 1200; the pulling wire 40 can be connected to the capture arm 1202 through the sheath tube 1130; The puller wire control mechanism 50 is connected with the puller wire 40, and the puller wire control mechanism 50 is configured to lock and pull the puller wire 40 under one working condition, so as to open and close the catch arm 1202; The pulling wire 40 is driven downward to dissociate from the valve clamp 1200 .

In the valve clamp control handle 100 proposed in this embodiment, the actuating wire control mechanism 30 can be adjusted to different working conditions to control the movement or rotation of the actuating wire 20, thereby realizing the opening and closing of the clamp arm 1201 in the valve clamp 1200. The control of the joint action can also realize the control of the dissociation action of the actuating wire 20 and the valve clamp 1200, which improves the functional integration of the actuating wire control mechanism 30; the pulling wire control mechanism 50 is set to drive the pulling wire 40. It can not only realize the control of the capture action of the capture arm 1202 in the valve clamp 1200, but also realize the control of the dissociation action of the pulling wire 40 and the valve clamp 1200, which improves the functional integration of the pulling wire control mechanism 50 Therefore, the valve clamp control handle 100 realizes the control of the entire working process of the valve clamp 1200 on the basis of a compact structure, which is convenient for the operator to operate and solves the problem of complicated operation steps of the valve clamp control handle 100. Improve the operation efficiency.

Please continue to refer to Fig. 6, and refer to Fig. 3 to Fig. 5 in combination, the housing 10 in the valve clip control handle 100 is used to install the actuating wire control mechanism 30, the pulling wire control mechanism 50 and the connecting sheath tube 1130, the housing 10 can Through three-dimensional printing or injection molding, in some embodiments of the present invention, as shown in FIG. 6 , the housing 10 includes a bottom case 102 and a top cover 101. In addition, the distal end of the shell 10 can also be connected with a sleeve, so as to improve the reliability of the connection between the bottom shell 102 and the top cover 101 .

Further, as shown in FIG. 4 and FIG. 6 , the valve clamp control handle 100 also includes a sheath fixing assembly 60, which is arranged in the housing 10 and is located near the distal end of the housing 10. In this embodiment In the example, the proximal end of the sheath tube 1130 is passed through the housing 10 and connected with the sheath tube fixing component 60, and the sheath tube fixing component 60 is connected with the housing 10, for example, the sheath tube fixing component 60 can be connected with the housing 10 by screws, Therefore, the movement of the sheath tube 1130 is prevented, that is, the sheath tube 1130 is prevented from moving or rotating relative to the housing 10 , so that the proximal end of the sheath tube 1130 is fixed in the housing 10 and remains stable.

Further, the sheath tube fixing assembly 60 may include two opposing pressure rings 61, the two pressure rings 61 are fastened and connected to hold the sheath tube 1130, for example, the two pressure rings 61 have the same structure, as shown in Figure 6 As shown, the cross section of the part where the compression ring 61 hugs the sheath 1130 is arc-shaped or semicircular, and the two sides of the compression ring 61 are extended with connecting plates. When the two compression rings 61 are fastened and connected, the two compression rings 61 The connecting plates on the same side of the ring 61 are aligned and abutted. On this basis, the two connecting plates can be connected by welding, or fasteners such as screws can be used to penetrate the two connecting plates, so that the two pressure rings 61 are connected and Hold the sheath 1130 tightly.

On the basis of the above-mentioned embodiment, as shown in FIG. 6 , the housing 10 is provided with an accommodating chamber 12 for installing the sheath tube fixing assembly 60. 11 communicates, taking the sheath tube fixing assembly 60 including two pressure rings 61, and the housing 10 including the bottom shell 102 and the top cover 101 as an example, the bottom shell 102 and the top cover 101 are respectively provided with grooves, and the two grooves are matched After the accommodating cavity 12 is formed, the two pressure rings 61 can also be connected with at least one of the bottom case 102 and the top cover 101 through screws and other fasteners on the basis of being connected, thereby further improving the sheath. The reliability of the connection between the tube fixing assembly 60 and the sheath tube 1130 and the housing 10 .

Further, as shown in FIGS. 4 to 6 , a sealed cavity 14 is provided in the housing 10, and the sealed cavity 14 is located on the proximal side of the accommodating cavity 12 and communicates with the accommodating cavity 12, so that the proximal end of the sheath tube 1130 Can extend into the sealed cavity 14 . In this embodiment, the sealing chamber 14 is surrounded by a sealing ring 80. For example, the opposite sides of the bottom shell 102 and the top cover 101 are respectively provided with corresponding annular grooves, and the sealing ring 80 is matched with the two annular grooves. The sealing ring 80 can adopt a rubber ring or the like. In addition, one or two exhaust ports 17 are provided on the casing 10, and the exhaust ports 17 communicate with the sealed cavity 14, and an exhaust valve (not shown in the figure) is connected to the exhaust ports 17.

Please continue to refer to FIG. 1 to FIG. 6, and refer to FIG. 7 in conjunction with the valve clip control handle 100. The sliding member 1203 of the valve clamp 1200 is connected to drive the sliding member 1203 to slide axially, and then drive the clamp arm 1201 to open and close. As shown in FIG. 7 , the actuating wire 20 is arranged axially, partly located in the casing 10 , the actuating wire 20 protrudes into the sheath tube 1130 near the distal end of the casing 10 , and extends to the valve clamp in the sheath tube 1130 . The sliding member 1203 of the coupler 1200 is connected. In this embodiment, the actuating wire 20 is threadedly connected with the sliding member 1203. For example, the distal end of the actuating wire 20 is provided with an external thread segment 21 to match the threaded hole in the sliding member 1203. , the threaded connection can ensure the stability when the actuating wire 20 drives the sliding member 1203 to move in the axial direction, and it is convenient for the operator to disengage the actuating wire 20 from the valve clamp 1200 by rotating the actuating wire 20 . It should be noted that the dissociation in this embodiment refers to the disconnection between the two. Further, the actuating wire 20 can be configured as a memory alloy wire, such as a nickel-titanium alloy wire.

Further, according to the above-mentioned embodiment, as shown in FIG. 6 , a guide hole 15 is also provided in the sealed cavity 14. For example, semicircular grooves are respectively provided on the opposite sides of the top cover 101 and the bottom case 102, and two semicircular grooves are provided. The grooves are combined to form a guide hole 15. In this embodiment, the guide hole 15 can be matched with the actuation wire 20 to limit the actuation wire 20 and provide guidance for the actuation wire 20 to prevent the actuation wire 20 from being in the sealed chamber. 14 inner bends.

According to the above embodiment, the actuating wire 20 is connected to the actuating wire control mechanism 30 , and the operator can control the actuating wire 20 to act by operating the actuating wire control mechanism 30 . Please refer to FIG. 7 , in some embodiments of the present invention, the actuating wire control mechanism 30 includes a pressing wire assembly 31 , a driving knob 32 and an unloading knob 33 arranged sequentially from the distal end to the proximal end, and the actuating wire 20 is passed through. in the above components. The wire pressing assembly 31 is slidably arranged in the housing 10 and is connected with the actuating wire 20 penetrating therein. The wire pressing assembly 31 is used to compress the actuating wire 20 . The driving knob 32 abuts against the wire pressing assembly 31 The proximal end is threadedly connected with the housing 10, the driving knob 32 is used to drive the actuating wire 20 to move, the unloading knob 33 is located on the proximal side of the driving knob 32, and is connected with the actuating wire 20 passing through it, and the unloading knob 33 is used To drive the actuating wire 20 to rotate.

On the basis of the above-mentioned embodiment, as shown in Fig. 4 to Fig. 6, the housing 10 is provided with a first slide hole 13 inwardly from the proximal end, the first slide hole 13 is located on the proximal side of the sealing cavity 14, and the wire pressing assembly 31 is at least partly slidably arranged in the first sliding hole 13. Taking the case 10 including a top cover 101 and a bottom case 102 as an example, the opposite sides of the top cover 101 and the bottom case 102 are respectively provided with grooves. The grooves are interlocked to form the first sliding hole 13 .

In this embodiment, the thread pressing assembly 31 includes a thread pressing post 311 , and the thread pressing post 311 is arranged in the first sliding hole 13 and can rotate and slide in the first sliding hole 13 . As shown in FIG. 7 , a first through hole 3111 is arranged in the thread pressing column 311 in the axial direction, and the actuating wire 20 is passed through the first through hole 3111 . Further, the thread pressing column 311 is provided with at least one The first locking hole 3112, the first locking hole 3112 communicates with the first through hole 3111, the first locking hole 3112 is used to install fasteners such as bolts or studs, and the first locking hole 3112 is locked by pressing the fasteners. The actuating wire 20 in a through hole 3111 , so that the actuating wire 20 is relatively fixed to the thread pressing post 311 , and the actuating wire 20 can move or rotate synchronously with the thread pressing post 311 .

Taking the fastener as an example, in an optional embodiment, the first locking hole 3112 is set as a blind hole, opening inward from the side wall of the thread pressing post 311 to the first through hole 3111 Through, the inner wall of the blind hole is provided with an internal thread, and the stud cooperates with the internal thread, and the bottom end of the stud abuts against the inner wall of the first through hole 3111, so as to pass through the first through hole 3111. Moving wire 20 is compressed. In another optional embodiment, the first locking hole 3112 is set as a through hole, and the first locking hole 3112 is divided into two sections by the first through hole 3111, wherein the hole section matched with the stud is threaded Hole section, the other section is set as a light hole section, further, the inner diameter of the light hole section can be larger than the inner diameter of the threaded hole section, so that the bottom of the stud extends into the light hole section, and will be located between the first through hole 3111 and the second through hole 3111. The actuating wire 20 at the penetrating part of a locking hole 3112 is pressed into a curved shape, which further improves the reliability of the connection between the actuating wire 20 and the pressing wire post 311 .

In this embodiment, the driving knob 32 is provided with a through hole along the axial direction, and the actuating wire 20 is slidably disposed in the through hole. The driving knob 32 includes a connected threaded rod 321 and a rotating head 322 , and the threaded rod 321 and the rotating head 322 may be provided as an integrated structure. The driving knob 32 is screwed to the proximal end of the first sliding hole 13, wherein the rotating head 322 is located outside the housing 10, and the threaded rod 321 is screwed in the first sliding hole 13. When the driving knob 32 rotates relative to the housing 10 , the threaded rod 321 moves axially in the first sliding hole 13 , thereby pushing the pressing wire assembly 31 and the actuating wire 20 to move axially, and then driving the clamp arm 1201 of the valve clamp 1200 to open or close.

Further, the diameter of the threaded rod 321 may be larger than the diameter of the thread pressing post 311, so that the first slide hole 13 in the casing 10 is set as a stepped hole, wherein the hole section with a larger diameter is located near the hole section with a smaller diameter. On the end side, the threaded rod 321 is matched with the hole section with a larger diameter. This arrangement makes the lead of the threaded rod 321 larger, so that the driving knob 32 can move axially for a longer distance under the condition of constant number of turns. , that is to say, the driving efficiency of the driving knob 32 is improved, which is convenient for the operator to operate.

In this embodiment, the unloading knob 33 is located on the proximal side of the driving knob 32 , that is, outside the casing 10 . According to the above-mentioned embodiment, the unloading knob 33 is connected with the actuating wire 20 passing through it. Exemplarily, the unloading knob 33 can be set in a cylindrical shape, so as to be easily twisted by the operator; the unloading knob 33 is provided with a second through hole 331 along the axial direction, and one or more second locking holes 332 are provided along the radial direction , the second locking hole 332 is used to install fasteners such as bolts or studs, and the actuating wire 20 located in the second through hole 331 is locked by means of fastener compression, thereby, the actuating wire 20 and the The unloading knob 33 is relatively fixed, and the actuating wire 20 can move or rotate synchronously with the thread pressing column 311 . Further, the second locking hole 332 can be set as a blind hole or a through hole, and the specific structure of the second locking hole 332 can refer to the first locking hole 3112 in the above-mentioned embodiment, which will not be repeated here.

It can be understood that in this embodiment, there is no gap between the proximal surface of the driving knob 32 and the distal surface of the unloading knob 33, so as to ensure that the driving knob 32 can drive the unloading pressure when the driving knob 32 moves axially toward the distal end or the proximal end. The wire assembly 31 and the unloading knob 33 move synchronously. On this basis, the valve clamp control handle 100 further includes a bearing 70, and the driving knob 32 and the unloading knob 33 are matched with the bearing 70 respectively. As shown in FIG. 7 , taking the driving knob 32 including a connected threaded rod 321 and a swivel head 322 as an example, the radial dimension of the swivel head 322 is greater than the radial dimension of the unloading knob 33, and the bearing 70 can be arranged in the swivel head 322, The unloading knob 33 is partially inserted in the rotating head 322 and cooperates with the bearing 70. In this embodiment, by setting the bearing 70, it is avoided that one of the driving knob 32 and the unloading knob 33 rotates to affect the other, which not only improves the accuracy The stability of the moving wire 20 when moving axially also avoids the problem of loose connection between the actuating wire 20 , the unloading knob 33 and the wire pressing assembly 31 caused by excessive torsion.

On the basis of the above-mentioned embodiment, the thread pressing assembly 31 also includes a limit block 312, which is detachably connected to the thread pressing column 311, and the connection method can be snap-in, plug-in, or pass through to facilitate disassembly. Fasteners are connected, or a combination of multiple connection methods at the same time. In this embodiment, the limiting block 312 is at least partially located on the proximal side of the thread pressing column 311, that is, it is clamped between the thread pressing column 311 and the driving knob 32. It can be understood that the setting of the limiting block 312 can avoid the above two The direct contact causes the thread pressing column 311 to rotate with the driving knob 32, thus, when the thread pressing column 311 and the actuating wire 20 move, unnecessary rotation can be avoided, thereby not only improving the axial movement of the actuating wire 20 It also avoids the problem of loose connection between the actuating wire 20 and the wire pressing column 311 and other structures caused by redundant torsion.

For example, please continue to refer to FIG. 7 , the bottom of the limiting block 312 is provided with a connecting post, and the connecting post is inserted into the connecting hole opened downward from the top of the thread pressing post 311 . Further, taking a plane perpendicular to the axial direction as the cross section, the cross-sectional shape of the limiting block 312 is rectangular, the proximal end surface of the limiting block 312 exceeds the proximal end surface of the pressing thread post 311, and the excess part extends toward the bottom to form a snap-fitting part 3122, the clamping part 3122 is clamped between the thread pressing column 311 and the driving knob 32, and according to the actuating wire 20 passing through the thread pressing column 311 and the driving knob 32, an avoidance groove can be arranged on the clamping part 3122 in the axial direction , to ensure smooth threading of the actuating wire 20 . Therefore, when the driving knob 32 rotates, since the limit block 312 cannot rotate, the thread pressing post 311 will not rotate either.

Further, please continue to refer to FIG. 7 , in some embodiments of the present invention, the thread pressing assembly 31 further includes a thumb screw 313 for connecting the limit block 312 and the thread pressing post 311 , for example, The thumb screw 313 is plugged into the limit block 312, and the handle screw extends into the thread pressing post 311 and is threadedly connected with the thread pressing post 311. The hand screw end of the thumb screw 313 is exposed outside the housing 10, which is convenient for the operator operation, thereby the thumb screw 313 can be unscrewed from its connection with the thread pressing post 311 , and then the limiting block 312 can be removed. In an optional embodiment, the limit block 312 is provided with a threaded hole, and the screw connection between the thumb screw 313 and the limit block 312 is set, so that the thumb screw 313 is disconnected from the thread pressing post 311 Finally, the thumb screw 313 is threadedly connected with the limit block 312, and the operator can drive the limit block 312 to disengage by pulling the thumb screw 313, which further improves the convenience of operation.

Further, please refer to FIG. 6 , the top of the housing 10 is provided with a first chute 131 , taking the housing 10 including a top cover 101 and a bottom case 102 as an example, the first chute 131 is provided on the top cover 101 , the first The chute 131 communicates with the first slide hole 13 in the casing 10. On this basis, referring to FIG. 3 to FIG. 5, the limiting block 312 is partly located in the first chute 131, and the width of the limiting block 312 is slightly smaller than The width of the first chute 131 is such that it is convenient to unload the limiting block 312 from the first chute 131 . Furthermore, the thumb screw 313 inserted into the limiting block 312 is exposed outside the housing 10 , so that it is convenient for the operator to twist and remove the limiting block 312 by pulling the thumb screw 313 , further improving the convenience of operation.

On the basis of the above-mentioned embodiment, the length of the first chute 131 is greater than or equal to the maximum distance that the wire pressing assembly 31 can move in the axial direction. The slot 131 slides. On this basis, the top surface of the limiting block 312 is higher than the top surface of the housing 10. Further, as shown in FIG. 7, at least one of the two sides of the limiting block 312 is provided with Indicating part 3121, the indicating part 3121 can be integrally formed on the columnar body on the limit block 312, or can be a pointer-shaped member connected to the limit block 312, correspondingly, the housing 10 is provided with multiple 3121 matched with the scale line 1011, the scale line 1011 can provide the operator with an indication of the axial movement position of the actuating wire 20 by marking the state of the clamp arm 1201 in the valve clamp 1200, such as the angle of closing and opening, etc., thereby It is convenient for the operator to observe and operate during the operation.

As shown in Fig. 4 and Fig. 7, in some embodiments of the present invention, the actuating wire control mechanism 30 also includes a wire tube 34, and the wire tube 34 can be specifically set as a stainless steel tube or a nickel-titanium alloy tube, and the wire tube 34 is arranged in the housing 10 , extends from the inside of the thread pressing post 311 toward the distal end, and its distal end penetrates into the sheath tube 1130 , and the actuating wire 20 is passed through the wire guide tube 34 . It can be understood that one end of the actuating wire 20 located in the housing 10 extends into the sheath 1130 , and the other end is connected with the actuating wire control mechanism 30 . The middle part of the center is prone to bending, so the wire guide tube 34 in this embodiment is used to limit the actuating wire 20 and prevent the actuating wire 20 from bending.

Further, according to the above-mentioned embodiment, the sealing cavity 14 of the housing 10 is provided with a guide hole 15 for restricting the actuating wire 20. In this embodiment, on the basis that the actuating wire control mechanism 30 includes a wire guide tube 34, The guide hole 15 is matched with the thread guide tube 34 , and the thread guide tube 34 can slide axially in the guide hole 15 . In addition, the sealing ring 80 enclosing and forming the sealing cavity 14 is provided with a through hole through which the threaded tube 34 passes, and the part near the proximal end of the threaded tube 34 extends to the first sliding hole 13 through the through hole, and is inserted into the first sliding hole 13. Set in the thread pressing column 311.

On the basis of the above-mentioned embodiment, the part of the thread pipe 34 inserted in the thread pressing column 311 extends to pass through at least one first locking hole 3112, and the fastener provided in the first locking hole 3112 is used for locking Tighten the harness pipe 34. Exemplarily, four first locking holes 3112 are provided on the thread pressing post 311, wherein two first locking holes 3112 near the far end of the thread pressing post 311 are provided with studs, and the ends of the two studs Both abut against the outer wall of the thread pipe 34, thereby locking the thread pipe 34; the studs provided in the other two first locking holes 3112 abut against the actuating wire 20 protruding from the thread pipe 34 , so as to lock the actuating wire 20, thus, when the thread pressing column 311 slides axially under the drive of the driving knob 32, the actuating wire 20 and the wire tube 34 both move axially synchronously with it, thereby preventing the actuating wire from 20 is bent, which improves the stability of the actuating wire 20 .

Please refer to Fig. 9 to Fig. 11, when the limit block 312 is connected on the thread pressing column 311, the actuating wire control mechanism 30 is in the first working condition, at this moment, the operator can turn the driving knob 32 clockwise or counterclockwise, so that The driving knob 32, the thread pressing column 311, the limit block 312, the wire tube 34, the unloading knob 33 and the actuating wire 20 move axially synchronously. Exemplarily, as shown in FIG. 9, when moving toward the distal end, the The clamp arm 1201 of the valve clamp 1200 is driven to open, as shown in FIG. 10 , when it moves toward the proximal end, the clamp arm 1201 can be driven to close. As shown in Figure 11, when the operator twists the thumb screw 313 and removes the limit block 312, the actuating wire control mechanism 30 is in the second working condition. At this time, the operator can turn the unloading knob 33 to make the unloading knob 33, The thread pressing column 311, the wire tube 34 and the actuating wire 20 rotate around their own axes synchronously, thereby releasing the threaded connection between the actuating wire 20 and the sliding member 1203 in the valve clamp 1200, that is, dissociating the actuating wire 20 and Valve clip 1200 . Therefore, in this embodiment, the actuating wire control mechanism 30 can change the working conditions only by removing the limit block 312, and then control the actuating wire 20 to achieve different actions, which improves the convenience of operation. When the valve repair system 1000 is used, the operation efficiency can be improved.

Please continue to refer to Fig. 1 to Fig. 6, and refer to Fig. 8 to Fig. 11 in combination, the pulling wire 40 is passed through the capture arm 1202, and the two wire ends of the pulling wire 40 extend toward the proximal end. The thread 40 can be a nickel-titanium alloy thread, or a medical suture thread. It should be noted that when the valve clamp 1200 includes two capture arms 1202, one puller wire 40 can be provided as one, and one puller wire 40 passes through the two capture arms 1202 in sequence, thereby controlling the two capture arms 1202 at the same time. The arm 1202 moves, and accordingly, the valve clip control handle 100 is provided with a pulling wire control mechanism 50 matched with the pulling wire 40; the pulling wire 40 can also be set to two, and each pulling wire 40 passes through It is connected to one capture arm 1202 so as to control the two capture arms 1202 to act independently. Correspondingly, the valve clip control handle 100 is provided with two puller wire control mechanisms 50 .

The following embodiments will be described by taking two puller wires 40 as an example. Please refer to FIG. 8 in conjunction with FIG. 4 and FIG. 5 . into the four channels, and penetrate into the housing 10 from the proximal end of the sheath tube 1130, and then the two wire ends of one of the puller wires 40 are extended and connected to a puller wire control mechanism 50, and the other puller wire 40 is connected to the Two wire ends of the wire 40 are extended and connected to another pulling wire control mechanism 50 . In this embodiment, the two puller wire control mechanisms 50 can be respectively arranged on both sides of the actuating wire control mechanism 30 , so as not only to avoid the two puller wires 40 from interfering with each other, but also to make full use of the space of the casing 10 .

Please continue to refer to FIG. 8 , and refer to FIGS. 9 to 11 in conjunction with FIGS. In the control rod 51, the control rod 51 is at least partly slidably arranged in the housing 10, and the control rod 51 can drive the pulling wire 40 to move, so as to make the catch arm 1202 open and close. Taking the two catch arms 1202 as an example, the present invention In the embodiment, the opening of the capture arms 1202 means that the two capture arms 1202 are relatively close to each other and are in a ready-to-catch state, and the closure of the capture arms 1202 means that the two capture arms 1202 are relatively far away and rotate toward the clamp arm 1201 to capture the valve. The wire locking member 52 is installed on the control rod 51, the wire locking member 52 locks the pulling wire 40 under the first working condition, and loosens the pulling wire 40 under the second working condition; the wire withdrawing member 53 is detachably installed on the The control rod 51 or the wire locking member 52 is connected to the pulling wire 40 , and the wire withdrawing member 53 can drive the pulling wire 40 to disengage from the catching arm 1202 under the second working condition.

On the basis of the above embodiments, the housing 10 is provided with a second sliding hole 16 , and the proximal wall of the housing 10 is provided with an opening, and the control rod 51 is slidably disposed in the second sliding hole 16 . Taking the housing 10 including a top cover 101 and a bottom case 102 as an example, grooves are provided on opposite sides of the top cover 101 and the bottom case 102 , and the two opposite grooves are interlocked to form a second sliding hole 16 . The number of the second sliding holes 16 is the same as the number of the pulling wire control mechanism 50 . In this embodiment, there are two second sliding holes 16 , and the two second sliding holes 16 are respectively located on both sides of the first sliding hole 13 .

Further, a limiting protrusion 5101 is provided on the control rod 51, correspondingly, as shown in FIG. The second limiting groove 163 is arranged along the sliding direction of the control rod 51. When the control rod 51 slides along the second sliding hole 16, the limiting protrusion 5101 can be aligned with the first limiting groove 162 or the second limiting groove 163. Cooperate. It can be understood that the control rod 51 can drive the pulling wire 40 to move, and then drive the capture arm 1202 of the valve clamp 1200 to open or close. In this embodiment, the first limiting groove 162 and the second limiting groove 163 can pass through Cooperate with the limit protrusion 5101 to keep the control rod 51 at a fixed position, and then keep the pulling wire 40 in the state of driving the catch arm 1202 to open or in the state of driving the catch arm 1202 to close and catch. Therefore, such setting This method improves the stability of the pulling wire 40 and is convenient for the operator to operate.

In an optional embodiment, the limiting protrusion 5101 can be set as an elastic structure. When the control rod 51 slides in the second sliding hole 16, the limiting protrusion 5101 produces elastic deformation. 162 or the second limiting groove 163 , the limiting protrusion 5101 recovers and deforms, and extends into the first limiting groove 162 or the second limiting groove 163 to form fit. In another optional embodiment, please refer to FIG. 8 , the limit protrusion 5101 is provided as a protrusion integrally formed on the control rod 51 , correspondingly, as shown in FIG. 6 , the casing 10 is provided with a The second sliding groove 161 connected to the second sliding hole 16, when the control rod 51 slides along the second sliding hole 16, the limiting protrusion 5101 slides in the second sliding groove 161, and the first limiting groove 162 and The second limiting grooves 163 communicate with the second sliding grooves 161 respectively, and are arranged along the length direction of the second sliding grooves 161, thus, when the limiting projections 5101 move to align with the first limiting grooves 162, the operation The operator can rotate the control lever 51 to make the limit protrusion 5101 match the first limit groove 162; when the limit protrusion 5101 moves to align with the second limit groove 163, the operator can rotate the control lever , so that the limiting protrusion 5101 matches the second limiting groove 163 .

On the basis of the above embodiments, taking the housing 10 including the top cover 101 and the bottom case 102 as an example, the second sliding groove 161 , the first limiting groove 162 and the second limiting groove 163 can all be arranged on the top cover 101 , and penetrate the top cover 101 along the thickness direction of the top cover 101, so as to facilitate the operator to observe and operate. On this basis, as shown in FIG. Embedded in the second sliding groove 161 , the first limiting groove 162 and the second limiting groove 163 , it plays a dustproof role. In this embodiment, the part of the control rod 51 located in the first sliding hole 13 is set as a cylinder, so that the control rod 51 can rotate around its own axis in the first sliding hole 13, and then drive the limit projection 5101 to rotate, and the limit The protrusion 5101 is arranged on the top of the control rod 51, and the operator can rotate the control rod 51 at any angle between 10° and 90°, so that the limiting protrusion 5101 is snapped into the first limiting groove 162 or the second limiting groove slot 163.

Further, a handle portion 512 is also provided on the control rod 51. The handle portion 512 can be set as a pull rod, can also be set as a pull ring, and can also be set as other shapes that are convenient for the operator to hold. In this embodiment, the handle portion 512 The shape is not specifically limited. The handle part 512 can be integrally formed on the control rod 51, for example, it can be located on the same side of the control rod 51 as the limit protrusion 5101, so that the operator can operate the control rod 51 to slide and rotate by holding the handle part 512, improving the convenience of operation sex.

Further, in an optional embodiment, both the thread locking member 52 and the thread withdrawal member 53 are installed on the control rod 51, wherein the thread withdrawal member 53 is connected to the proximal end of the control rod 51; in another optional In the embodiment, as shown in FIG. 8 , the thread locking member 52 is connected to the proximal end of the control rod 51 , and the thread withdrawing member 53 is connected to the proximal end of the thread locking member 52 . On this basis, the thread withdrawal member 53 is configured as a thread withdrawal knob, and the thread withdrawal knob is screwed to the proximal end of the thread locking member 52. Exemplarily, the proximal end of the thread locking member 52 is provided with external threads, and the thread withdrawal knob A threaded hole is provided on the top, so that the thread withdrawal knob is detachably sleeved on the thread locking member 52 . The threaded connection in this embodiment facilitates the disassembly of the thread withdrawing member 53, which improves the convenience of operation.

Further, as shown in FIG. 8 , the control rod 51 is axially provided with a wire hole 511 for the pull wire 40 to pass through. The distal end of the rod 51 passes through the wire passing hole 511 . Taking the control rod 51, the thread locking member 52 and the thread withdrawing member 53 as an example, the two wire ends of the pulling wire 40 stretch out from the control rod 51 and then extend into the thread locking member 52, and according to the thread locking member 52 The working condition is locked or loosened.

In some embodiments of the present invention, the locking wire member 52 is set as a two-way valve, and the two-way valve includes a valve body and a handle, the handle is located on the top of the valve body, and connecting pipes protrude from both sides of the valve body, wherein The connecting tube near the far end is used to connect with the control rod 51, and the connection method can be welding, threaded connection, etc. to ensure the reliability of the connection; the connecting tube near the proximal end is used to connect with the thread withdrawal knob. In this embodiment, when the two-way valve is in the closed state, it can squeeze the pulling wire 40 pierced therein to lock it, and when the two-way valve is in the open state, it can loosen the pulling wire 40. Such a setting It is convenient for the operator to operate, and can ensure the stability of the pulling wire 40 .

On the basis of the above-mentioned embodiment, among the two wire ends of the pulling wire 40, the first wire end extends to cooperate with the locking wire member 52, and the second wire end of the pulling wire 40 extends to connect with the withdrawal knob and can Move with the thread withdrawal knob, that is to say, both wire ends of the pulling wire 40 are matched with the locking wire member 52. Taking the locking wire member 52 as a two-way valve as an example, the first wire end can extend to the two-way valve The proximal end of the connecting tube, and the second wire end extends to the thread withdrawal knob, which can be directly connected to the thread withdrawal knob, or can be clamped between the thread withdrawal knob and the connecting tube. As shown in Fig. 9 and Fig. 10, when the two-way valve is closed, both wire ends are locked, and at this time, the pulling wire 40 is relatively fixed with the control rod 51 and the locking wire member 52, and the operator can slide the The control rod 51 moves the pulling wire 40 in the axial direction, and then drives the catch arm 1202 of the valve clamp 1200 to open or close; as shown in Figure 11, when the two-way valve is opened, both wire ends are loosened At this time, the operator can pull the second wire end to draw out the puller wire 40 , and dissociate the puller wire 40 from the valve clamp 1200 .

In some embodiments of the present invention, the second wire end of the pulling wire 40 is connected to the wire withdrawal knob, so that the operator can pull out the pulling wire 40 while unloading the wire withdrawal knob, and the operation is simple. Further, the connection method between the second wire end of the pulling wire 40 and the thread withdrawal knob may be a fixed connection such as bonding, or, in another optional embodiment, as shown in FIG. 8 , the thread withdrawal knob is Two through holes are arranged in the direction, and the second wire end of the pulling wire 40 is threaded through the two through holes in a detour. Exemplarily, the distal end of the thread withdrawal knob can be provided with a mounting column 531, two through holes are provided through the mounting column 531, and the proximal end of the mounting column 531 is located inside the thread withdrawal knob, thereby avoiding the pulling wire 40 from being exposed, The second wire end of the pulling wire 40 passes through one of the through holes in the direction from the distal end to the proximal end, and then passes through the other through hole in the direction from the proximal end to the distal end, thereby passing back to the distal side of the wire withdrawal knob , on this basis, the second wire end is provided with a knotting portion 41, the radial dimension of the knotting portion 41 is larger than the radial dimension of the through hole, so that the knotting portion 41 is clamped on the distal side of the thread withdrawal knob, and the This puller wire 40 is connected with the wire withdrawal knob, and when the thread locking member 52 is in the second working condition, that is, when the puller wire 40 is released, when the operator unloads the wire withdrawal knob, the puller wire 40 can follow the wire withdrawal knob Move to disengage from the valve clip 1200 .

Please refer to Fig. 9 and Fig. 10, when the two-way valve is closed, the pulling wire control mechanism 50 is in the first working condition, at this moment, the operator can slide the control rod 51 in the axial direction, so that the control rod 51, the two-way valve, the withdrawal The wire knob and the pulling wire 40 move synchronously. When sliding toward the proximal end, it can drive the catch arm 1202 to open and enter the working condition to be caught; When 40 is loosened, the capture arm 1202 will return to its original state, that is, it will rotate and close toward the clamp arm 1201 to capture the valve. After the capture of the valve is completed, please refer to Figure 11, the operator can open the two-way valve and loosen the pulling wire 40, at this time the pulling wire control mechanism 50 is in the second working condition, and the operator can turn the wire withdrawal knob Unload it, and then pull out the pulling wire 40 , so as to release the connection between the pulling wire 40 and the capture arm 1202 , that is, separate the pulling wire 40 from the valve clamp 1200 . Therefore, in this embodiment, the pulling wire control mechanism 50 changes the working condition through the opening and closing of the two-way valve, and then the dissociation can be completed only by unloading the wire withdrawal knob, and there is no need to find the wire end or cut the pulling wire 40 in order to pull out the pulling wire 40. The pull wire 40 improves the convenience of operation, and when applied to the delivery device 1100 and the valve repair system 1000, can improve the operation efficiency.

Please refer to FIG. 1 , the embodiment of the second aspect of the present invention proposes a delivery device 1100 , which can be used in interventional therapy for delivery of implants such as artificial valves, stents, and valve clips 1200 . In this embodiment, the delivery device 1100 includes a sheath tube 1130, an adjustable curved sheath 1110, a sheath tube bending handle 1120, and a valve clip control handle 100 according to the embodiment of the first aspect. The handle 1120 is connected, and under the control of the sheath tube bending handle 1120, it bends toward the set direction, so as to reach the designated position through the interventional channels in the patient's body, such as venous blood vessels, during the operation; the sheath tube 1130 is movable through the adjustable bend In the sheath 1110 , the proximal end of the sheath tube 1130 is connected in the valve clip control handle 100 .

In this embodiment, the adjustable curved sheath 1110 is a hollow sheath tube whose distal end can be bent or manipulated. The adjustable curved sheath 1110 is straight or nearly straight when it is not subjected to bending force. The sheath 1110 is provided with an adjustable elbow section near the distal end, and the control line in the sheath tube bending handle 1120 is connected with the adjustable elbow section, thus, the sheath tube bending handle 1120 can make the sheath bend by pulling the control line. The distal end of the tube bend handle 1120 is bent. On this basis, the sheath tube 1130 is passed through the adjustable curved sheath 1110 and can be bent synchronously with the adjustable curved sheath 1110 .

Please continue to refer to FIG. 1, the embodiment of the third aspect of the present invention proposes a valve repair system 1000, the valve repair system 1000 includes a valve clamp 1200 and a delivery device 1100 according to the embodiment of the second aspect, the delivery device 1100 The sheath tube 1130 is detachably connected with the valve clamp 1200 to transport the valve clamp 1200 .

Exemplarily, the delivery device 1100 includes two adjustable curved sheaths 1110, two sheath tube bending handles 1120, one sheath tube 1130 and one valve clip control handle 100, and the two adjustable curved sheaths 1110 are respectively primary sheaths 1111 and the secondary sheath 1112, the secondary sheath 1112 is set in the primary sheath 1111, and the two sheath tube bending handles 1120 are matched with the primary sheath 1111 and the secondary sheath 1112 respectively, and are used to control the primary sheath 1111 and the secondary sheath 1112. The first-level sheath 1112 bends toward the set direction; the sheath tube 1130 is passed through the second-level sheath 1112, and the distal end of the sheath tube 1130 protrudes from the second-level sheath 1112 and is detachably connected with the valve clamp 1200; the proximal end of the sheath tube 1130 The secondary sheath 1112 is extended and connected in the valve clip control handle 100 .

When the valve repair system 1000 proposed in this embodiment is applied to the mitral valve repair operation, the operator controls the first-level sheath 1111 to reach the designated position in the patient through the established intervention channel by operating the sheath tube bending handle 1120, and the second-level sheath The sheath 1112 protrudes from the primary sheath 1111 and drives the sheath tube 1130 and the valve clamp 1200 to the vicinity of the mitral valve. After the position is adjusted, as shown in FIG. 9 , by turning the driving knob 32 of the actuating wire control mechanism 30, Drive the actuating wire 20 to move toward the distal end, so that the clamp arm 1201 of the valve clamp 1200 is opened, and by pushing the control rod 51 of the puller wire control mechanism 50, the puller wire 40 is driven to move toward the proximal end, so that the valve clamper The catching arm 1202 of 1200 is opened and stays at a position where the valve can be caught, and then the control rod 51 is pushed toward the distal end to loosen the pulling wire 40, so that the catching arm 1202 recovers its deformation and rotates toward the clamp arm 1201 to complete alignment. Catch the valve; reversely turn the driving knob 32, as shown in Figure 10, to drive the actuating wire 20 to move towards the proximal end, so that the clamp arm 1201 is closed to complete the clamping; as shown in Figure 11, open the pulling wire control mechanism 50 the two-way valve, and unscrew the wire withdrawal knob, pull out the puller wire 40, and dissociate the puller wire 40 from the valve clamp 1200; turn the thumb screw 313 in the actuating wire control mechanism 30, and unload the limit Block 312, the unloading knob 33 is turned to disengage the actuator wire 20 from the valve clamp 1200, and finally the primary sheath 1111, secondary sheath 1112 and sheath tube 1130 are withdrawn. During the use of the valve repair system 1000 proposed in this embodiment, the operator can complete actions such as delivering the valve clamp, catching the valve, clamping the valve, dissociating and withdrawing the delivery device without using external tools, and has a high degree of functional integration , easy to operate.

The above is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Anyone skilled in the art can easily think of changes or substitutions within the technical scope disclosed in the present invention. All should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims (10)

1. A valve clip control handle for controlling a valve clip, the valve clip comprising a plurality of relatively open and closed clamping arms, wherein the valve clip control handle comprises a housing, an actuator wire partially located in the housing, and an actuator wire control mechanism, a distal end of the actuator wire being threadably connectable with the valve clip via a sheath, the actuator wire control mechanism comprising:

the wire pressing assembly is slidably arranged in the shell and connected with the actuating wire, and the wire pressing assembly is arranged to be capable of synchronously moving with the actuating wire under a first working condition;

the driving knob is abutted against the near end of the wire pressing component and is in threaded connection with the shell, and the driving knob can push the wire pressing component and the actuating wire to move so as to drive the clamping arm to open and close;

the unloading knob is abutted to the proximal end of the driving knob and connected with the actuating wire, the unloading knob can synchronously move with the actuating wire under the first working condition, and the unloading knob can drive the actuating wire to rotate to be dissociated from the valve clamp under the second working condition.

2. The valve clamp control handle according to claim 1, wherein the wire pressing assembly comprises a wire pressing column and a limiting block, the actuating wire is inserted into the wire pressing column, the limiting block is detachably connected to the wire pressing column and at least partially located on a proximal end side of the wire pressing column, and the limiting block can prevent the wire pressing column from rotating under a working condition of being connected with the wire pressing column.

3. The valve clip control handle of claim 2, wherein the wire pressing assembly further comprises a thumb screw inserted into the limiting block and detachably connected to the wire pressing post, and an end of the thumb screw is exposed outside the housing.

4. The valve clip control handle of claim 2, wherein the actuator wire control mechanism further comprises a guidewire tube extending distally from within the guidewire post and configured to be threaded into the sheath, the actuator wire partially threaded into the guidewire tube.

5. The valve clip control handle according to claim 4, wherein the wire pressing column is provided with a first through hole in an axial direction, and at least one first locking hole in communication with the first through hole in a radial direction, the first locking hole being used for installing a fastener to lock the actuating wire and/or the wire passing tube in the first through hole.

6. The valve clip control handle of claim 1, further comprising a bearing, the drive knob and the unload knob cooperating with the bearing, respectively.

7. The valve clip control handle of claim 6, wherein the drive knob comprises a threaded rod and a rotating head connected, the bearing being disposed within the rotating head, the unload knob portion being inserted into the rotating head and cooperating with the bearing.

8. The valve clip control handle of claim 1, wherein the unloading knob is axially provided with a second through-hole and radially provided with one or more second locking holes for mounting a fastener to lock the actuating wire in the second through-hole.

9. A delivery device comprising a sheath, an adjustable curved sheath, a sheath bend adjustment handle, and the valve clamp control handle of any of claims 1-8, wherein the adjustable curved sheath is connected to the sheath bend adjustment handle, the sheath is movably disposed in the adjustable curved sheath, and a proximal end of the sheath is connected to the valve clamp control handle.

10. A valve repair system comprising a valve binder and the delivery device of claim 9, the sheath of the delivery device being removably attachable to the valve binder to deliver the valve binder.

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