CN115212399A - Pulse type nitric oxide therapeutic apparatus - Google Patents

Abstract

The invention discloses a pulse type nitric oxide therapeutic apparatus.A gas flow instrument and a proportional valve are arranged in a shell; the pressure reduction type NO gas supply device is connected with a gas flowmeter through a gas pipeline; the gas flow meter is connected with the gas transmission device through a gas pipeline; the proportional valve is arranged on a gas pipeline between the pressure reduction type NO gas supply device and the gas flow instrument or between the gas flow instrument and the gas transmission device; the gas transmission device is connected with the patient; one end of the respiration receptor is connected with the intubation of the gas transmission device, and the other end of the respiration receptor is connected with the electronic control module; the gas flow meter and the proportional valve are respectively and electrically connected with the electronic control module; the electronic control module is electrically connected with the power supply module. The nitric oxide therapeutic apparatus has the advantages of smaller occupied area, more flexible operation, convenience in carrying and maintenance and safer use, and can convey NO gas to a patient in a pulse mode for a few times, improve the gas suction comfort, save NO gas sources and prevent NO gas from being released into the environment.

Description

A pulsed nitric oxide therapeutic apparatus

technical field

The invention belongs to the technical field of medical equipment, and particularly relates to a pulsed nitric oxide therapeutic apparatus.

Background technique

Pulmonary hypertension is divided into arterial pulmonary hypertension, pulmonary hypertension due to left heart disease, pulmonary hypertension due to pulmonary disease and/or hypoxia, chronic thromboembolic pulmonary hypertension, pulmonary hypertension due to other pulmonary arterial obstructive diseases, or multiple factors pulmonary arterial hypertension, which is a major global health problem. Nitric oxide (NO) is a powerful vasodilator that directly relaxes vascular smooth muscle by stimulating soluble guanylate cyclase and increasing intracellular cyclic guanosine monophosphate production. Since pulmonary hypertension is associated with defective secretion of endogenous NO, NO-induced vasodilation is attenuated.

NO inhalation therapy is considered to be a successful and innovative therapy, nitric oxide is often used in masks, nasal cannula and patients receiving mechanical ventilation, limiting the mixing of nitric oxide and high concentrations of inhaled oxygen can reduce the adverse effects of nitrogen dioxide formation risk of impact. Although inhaling excess nitric oxide (500 to 1000 ppm) can be toxic, studies over the years have shown that inhalation of nitric oxide at concentrations below 40 ppm for up to 6 months is minimally toxic to the lungs, and in the absence of methemoglobin In the case of reductase deficiency, inhaled nitric oxide up to 40 ppm is clinically available without causing methemoglobinemia in adults. The role of inhaled NO in regulating pulmonary vasomotor tone has been demonstrated, and NO inhalation therapy is considered as a potential treatment for pulmonary arterial hypertension. , without causing systemic vasodilation and hypotension. In the treatment of pulmonary arterial hypertension, a mean reduction of 30% (10 ppm/min) in pulmonary vascular resistance to NO has been used to determine pulmonary arterial drug responsiveness testing for long-term treatment benefit, and the optimal dose of inhaled NO must be determined for each patient Targeted adjustment of the treatment goals to determine, at least once every two days in the early stage. Clinical trials of inhaled NO in multiple groups of neonates with persistent pulmonary hypertension have shown that inhaled NO can improve the ventilation/perfusion ratio and oxygenation, and reduce pulmonary arterial pressure.

In conclusion, inhaled NO is a selective pulmonary vasodilator that can improve ventilation/perfusion ratio, improve oxygenation, and reduce pulmonary hypertension at low doses, so for patients with pulmonary hypertension and hypoxemia, inhalation NO can be used as a treatment.

Nitric oxide therapeutic apparatus is a commonly used device in NO inhalation therapy. Internationally, inhaled NO therapeutic apparatus is concentrated in developed countries in Europe and America. Among them, the NO therapeutic devices of Bellerophon Therapeutics Inc and Nu-Med Plus are mainly characterized by being portable and home-use. It can be connected to a nasal cannula for direct inhalation, but it lacks a corresponding monitoring device for the patient's vital signs, no alarm mechanism, and it cannot Connect the ventilator. Due to the monopoly position of Air Liquide S.A in the US gas source, VERO Biotech LLC and Beyond Air Inc have developed a NO generator, but its cost is high, which is not conducive to popularization. In addition, Canada's Novoteris LLC produces both NO medical grade gas and NO therapeutic apparatus, but they locate high concentrations of NO, which is contrary to the existing basic and clinical research results. Like Air Liquide S.A, British BOC Healthcare and German Linde Plc are major suppliers of medical-grade NO in Europe. The SLE3600 of the British INOSYS Inhaled Nitric OxideSystem Company is mainly aimed at the auxiliary inhalation NO treatment of patients treated by ventilator, and its application is limited.

SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to provide a pulsed nitric oxide therapeutic apparatus, which is simple, portable, safe to use, and can effectively improve the NO of patients through pulsed gas supply. Inhalation comfort and save NO gas source.

In order to achieve the above technical purpose, the technical scheme adopted in the present invention is: a pulsed nitric oxide therapeutic apparatus, comprising a decompression type NO gas supply device and a casing;

A gas flow meter and a proportional valve are installed in the housing;

The pressure-reducing NO gas supply device is connected to a gas flow meter through a gas pipeline;

The gas flow meter is connected to the gas transmission device through a gas pipeline;

The proportional valve is installed on the gas pipeline between the decompression NO gas supply device and the gas flow meter,

Or on the gas pipeline between the gas flow meter and the gas transmission device;

The gas transmission device is connected to the patient and is used to transmit NO gas;

One end of the breathing sensor is connected to the intubation of the gas transmission device, and the other end is connected to the electronic control module;

The gas flow meter and the proportional valve are respectively electrically connected to the electronic control module;

The electronic control module is electrically connected to the power module.

Further, the decompression type NO gas supply device includes an NO gas storage tank and a decompression device;

The NO gas storage tank is connected with the inlet pipeline of the pressure reducing device;

The outlet pipeline of the pressure reducing device is connected with a gas flow meter or a proportional valve.

Further, the NO gas storage tank is an NO cylinder, the volume specification of the NO cylinder is 50-20000ml, and the working pressure specification of the NO cylinder is 1-10MPa.

Further, the pressure reducing device is any one of a pressure relief valve, a pressure reducing valve, a solenoid valve, an electric valve, a pneumatic valve, a stop valve, a pressure reducer, and a flow limiting valve.

Further, the gas delivery device is a nasal cannula or a breathing mask or an endotracheal tube.

Further, the pulsed nitric oxide therapeutic apparatus also includes a NO gas concentration monitoring device, a NO ₂ gas concentration monitoring device and an alarm;

The NO gas concentration monitoring device and the NO ₂ gas concentration monitoring device are installed on the gas pipeline in the casing, and are respectively used for monitoring the NO gas concentration and the NO ₂ gas concentration in the gas pipeline;

the alarm is installed on the casing;

The NO gas concentration monitoring device, the NO ₂ gas concentration monitoring device and the alarm are respectively connected with the electronic control module.

Further, the electronic control module includes an electrically connected central processing unit and a human-computer interface;

The human-computer interaction interface is embedded on the casing;

The gas flow meter, the breathing sensor, the NO gas concentration monitoring device, and the NO gas concentration monitoring device are respectively connected to the signal input ends of the central processing unit _;

The decompression device, the proportional valve and the alarm are respectively connected to the signal output end of the central processing unit;

The power module is connected to the power interface of the central processing unit.

Further, the pulsed nitric oxide therapeutic apparatus also includes a gas pressure monitoring device and a binary flow control valve;

The gas pressure monitoring device and the binary flow control valve are sequentially installed on the gas pipeline between the proportional valve and the gas transmission device along the airflow direction;

The gas pressure monitoring device is connected to the signal input end of the central processing unit;

The binary flow control valve is connected to the signal output end of the central processing unit.

Further, the human-computer interaction interface includes matching applicable display screens and control panels;

The control panel is provided with a NO concentration input interface, a NO gas flow input interface, a proportional valve adjustment interface, a binary flow control valve adjustment interface and a vital sign parameter input interface;

The NO concentration input interface is used to input the required NO gas concentration;

The NO gas concentration is 0-100ppm;

The NO gas flow input interface is used to input the required NO gas flow;

The proportional valve adjustment interface is used to input the opening ratio of the proportional valve;

The opening ratio of the proportional valve is 1:1 to 1:100;

The gas flow speed controlled by the proportional valve is 0-10L/min, and the precision is 0.01L/min;

The binary flow control valve adjustment interface is used to input the opening ratio of the proportional valve and the binary flow control valve;

The opening ratio of the proportional valve and the binary flow control valve is 1:1 to 1:10;

The vital sign parameter input interface is used to input vital sign parameters;

The vital sign parameters include age, sex, height, weight, vital capacity, tidal volume and pulmonary artery pressure.

Further, the pulsed nitric oxide therapeutic apparatus further includes a vital sign monitoring device, and the vital sign monitoring device is electrically connected to the electronic control module.

Compared with the prior art, the present invention has the following beneficial effects:

1) The pulsed nitric oxide therapeutic apparatus of the present invention can sense the inhalation state of the patient by setting the respiration sensor, and when the patient inhales, transmits the inhalation signal to the electronic control module, and the electronic control module controls the inhalation signal according to the received inhalation signal. The proportional valve opens the valve at a certain opening ratio to input an appropriate amount of NO gas to the patient, but when the patient exhales, the respiratory receptor does not respond and stops inputting NO gas to the patient; the pulsed nitric oxide therapeutic apparatus of the present invention adapts to the breathing state of the patient by adapting to the breathing state of the patient. On the one hand, it can input an appropriate amount of NO gas to the patient to improve the comfort of use; on the other hand, it can avoid the waste of resources caused by the continuous output of NO gas, and prevent the release of NO gas into the environment, resulting in local oxidation and excessive production of NO ₂ ;

2) The pulsed nitric oxide therapeutic apparatus of the present invention can effectively obtain the patient's physical condition information by setting the vital sign monitoring device, and adaptively adjust the treatment method such as NO gas concentration and gas flow, and improve the NO inhalation treatment efficiency;

3) The pulsed nitric oxide therapeutic apparatus of the present invention can be further refined and input NO gas to the patient in a small amount and many times on the basis of a proportional valve and a proper amount of gas by setting a gas pressure monitoring device and a binary flow control valve, and further. Improve the patient's inhalation comfort of gas and the accuracy of NO gas flow per transmission;

4) The nitrogen source of the pulsed nitric oxide therapeutic apparatus of the present invention comes from the NO cylinder, and compared with nitrogen supply equipment such as NO generators, the equipment occupies a smaller area, is more flexible in operation, is easy to carry and maintain, and is safer to use;

5) In the present invention, by setting the gas concentration detection device and the alarm, when the gas concentration exceeds the threshold, the medical staff can be reminded through the alarm and dealt with in time, thereby improving the safety of use.

Description of drawings

1 is a schematic diagram of the overall structure of the pulsed nitric oxide therapeutic apparatus according to Embodiment 1 of the present invention;

2 is a schematic diagram of the internal structure of the shell of the pulsed nitric oxide therapeutic apparatus according to Embodiment 1 of the present invention;

3 is a schematic diagram of the internal structure of the shell of the pulsed nitric oxide therapeutic apparatus according to Embodiment 2 of the present invention.

The reference signs are: pressure reducing NO gas supply device 1, NO gas storage tank 1-1, pressure reducing device 1-2, housing 2, gas flow meter 3, proportional valve 4, gas transmission device 5, breathing Sensor 6, central processing unit 7-1, man-machine interface 7-2, power supply module 8, NO gas concentration monitoring device 9, NO ₂ gas concentration monitoring device 10, alarm 11, gas pressure monitoring device 12, binary flow control valve 13.

Detailed ways

The technical solutions of the present invention will be described in further detail below with reference to the embodiments and accompanying drawings. The following examples are only used to illustrate the present invention and not to limit the scope of the present invention.

Example 1

As shown in FIG. 1 , a pulsed nitric oxide therapeutic apparatus of the present invention includes a decompressed NO gas supply device 1, a housing 2 and an electronic control module; the electronic control module includes a central processing unit 7-1 and a Human-computer interaction interface 7-2, the human-computer interaction interface 7-2 is embedded on the casing 2, and the human-computer interaction interface 7-2 includes a display screen and a control panel suitable for matching; There are NO concentration input interface, NO gas flow input interface and proportional valve adjustment interface; the NO concentration input interface is used to input the required NO gas concentration; the NO gas concentration is 0-100ppm; the NO gas flow input interface It is used to input the required NO gas flow; the proportional valve adjustment interface is used to input the opening ratio of the proportional valve 4; it is connected to the central processing unit 7-1 through the man-machine interface 7-2, and the input parameters are transmitted to The central processing unit 7-1; the power module 8 is connected to the power interface of the central processing unit 7-1 to supply power to the pulsed nitric oxide therapeutic apparatus; the housing 2 is provided with a gas flow meter 3 and a proportional valve 4; The gas supply device 1 includes a NO gas storage tank 1-1 and a pressure reducing device 1-2. The pressure reducing device 1-2 is a pressure relief valve. The inflow pressure of the pressure relief valve is 1-10MPa, and the outflow pressure and flow rate are The range is subject to the pressure of the following accessories; the NO gas storage tank 1-1 is connected to the inlet pipeline of the pressure relief valve; the outlet pipeline of the pressure relief valve includes the detection gas path and the setting gas path; the device The fixed gas path is connected to the signal output end of the central processing unit 7-1, and the detection gas path is connected to the gas flow meter 3; the gas flow meter 3 is connected to the signal input end of the central processing unit 7-1, and used to The gas flow in the pipeline is transmitted to the central processing unit 7-1; the gas flow meter 3 is connected to the proportional valve 4 through the gas pipeline, and the proportional valve 4 is connected to the signal output end of the central processing unit 7-1, and the central processing unit 7-1 passes through Adjust the opening ratio of the proportional valve 4 to adjust the gas flow in the gas pipeline; the proportional valve 4 is connected to the gas transmission device 5 through the gas pipeline, and the gas transmission device 5 is a nasal cannula, and the patient wears the nasal cannula to inhale the NO treatment gas; breathing; One end of the sensor 6 is connected to the nasal cannula cannula to sense the patient's breathing, and the other end is connected to the signal input end of the central processing unit 7-1, which is responsible for converting the felt pressure into a signal received by the central processing unit 7-1 and transmitting it to the central processing unit. 7-1; a NO gas concentration monitoring device 9 and a NO ₂ gas concentration monitoring device 10 are also installed on the gas pipeline in the housing 2, which are respectively used to monitor the NO gas concentration and NO ₂ gas concentration in the gas pipeline; NO gas concentration The monitoring device 9 and the NO ₂ gas concentration monitoring device 10 are respectively connected to the signal input ends of the central processing unit 7-1, and transmit the detected NO gas concentration and NO ₂ gas concentration in the gas pipeline to the central processing unit 7-1; An alarm 11 is also installed on the housing ₂ , and the signal output end of the central processing unit 7-1 is connected to the alarm 11. When the NO or NO2 concentration exceeds the set threshold, the alarm 11 will alarm; computer interface 7-2 Make the central processing unit 7-1 control the pressure reducing device 1-2 to adjust the inlet pressure to the required outlet pressure, and the alarm can be released.

In this embodiment, the NO gas storage tank 1-1 is preferably an NO cylinder, the volume specification of the NO cylinder is 50-20000ml, and the working pressure specification of the NO cylinder is 1-10MPa.

In this embodiment, the NO gas concentration monitoring device 9 and the NO ₂ gas concentration monitoring device 10 can be selected from commercially available NO gas sensors and NO ₂ gas sensors; their sensing ranges are both 0-100PPM, and the precisions are both 0.1PPM.

In this embodiment, the pressure reducing device 1-2 may also be any one of a pressure reducing valve, a solenoid valve, an electric valve, a pneumatic valve, a stop valve, a pressure reducer, and a flow limiting valve.

In this embodiment, the gas outlet pipeline of the decompression device 1-2 can also be directly connected to the gas flow meter 3, and its pressure can be adjusted manually (Fig. 1 and Fig. 2 show the manual adjustment mode).

In this embodiment, the gas flow range of the gas flow meter 3 is 0-10 L/min, and the precision is 0.01 L/min.

In this embodiment, the proportional valve 4 can also be installed on the front end of the gas flow meter 3, that is, on the gas pipeline between the decompression NO gas supply device 1 and the gas flow meter 3;

The opening ratio of the proportional valve 4 is 1:1-1:100, the controlled gas flow rate is 0-10L/min, and the precision is 0.01L/min.

In this embodiment, the gas transmission device 5 may also be a breathing mask or a tracheal intubation or the like.

In this embodiment, the respiratory sensor 6 can be purchased through commercial channels, such as the commercially available full-series force-sensitive sensor for ventilator SM7391-BCE-S-500-000 (Shenzhen Yijiajie Electronic Technology Co., Ltd.) or SM5651-001D -American pressure sensor for industrial control of 3S ventilator anesthesia machine monitor (Shenzhen Yijiajie Electronic Technology Co., Ltd.).

Preferably, the pulsed nitric oxide therapeutic apparatus can also be provided with a vital sign monitoring device, such as a vital sign monitor, and the vital sign monitoring device is electrically connected to the electronic control module for monitoring the vital signs information of the patient, such as oxygen Saturation, respiratory rate, heart rate, etc. are transmitted to the electronic control module and displayed on the display screen. According to the received patient vital signs information, medical staff can modify the treatment plan on the control panel, including NO gas concentration and airflow.

Wherein, the control panel is further provided with a vital sign parameter input interface for inputting vital sign parameters;

When the vital sign monitoring device is not connected with the electronic control module, the vital sign parameters monitored by the vital sign monitoring device can be input through the vital sign parameter input interface;

The vital sign parameters include age, gender, height, weight, vital capacity, tidal volume, pulmonary artery pressure, and the like.

work process:

According to the patient's vital sign information transmitted by the vital sign monitoring device or the treatment plan set by the doctor, enter the required NO gas concentration and gas flow rate and the opening ratio of the proportional valve 4 in the human-machine interface 7-2; the patient wears the gas transmission device 5 . When starting the work, the NO gas in the NO gas storage tank 1-1 is decompressed by the decompression device 1-2 and then transferred to the gas pipeline. The NO gas concentration monitoring device 9 and the NO ₂ gas concentration monitoring device 10 monitor the gas in the gas pipeline in real time. The concentration of NO gas and NO ₂ gas is transmitted to the electronic control module. When the NO or NO ₂ concentration exceeds the set threshold, the alarm 11 will give an alarm; at this time, the user or medical staff makes the central The processor 7-1 controls the pressure reducing device 1-2 to adjust the inlet pressure to the required outlet pressure to release the alarm; when the gas concentration in the gas pipeline is normal, the NO gas continues to be transmitted to the proportional valve 4 through the gas flow meter 3. At the moment of inhalation, the respiration sensor 6 senses the patient's breathing, and converts the sensed pressure into a signal received by the central processing unit 7-1 and transmits it to the central processing unit 7-1. After receiving the signal, the central processing unit 7-1 controls The proportional valve 4 opens the valve according to the set opening ratio, so that the NO gas is transmitted to the patient through the gas transmission device 5 according to the required gas flow speed for NO inhalation therapy; when the patient exhales, the respiratory sensor 6 does not respond, and at this time, The central processing unit 7-1 controls the proportional valve 4 to close, and NO gas is no longer transmitted to the patient until the patient inhales again, and the respiration sensor 6 responds again to perform a new round of NO inhalation therapy.

Compared with the existing NO therapeutic apparatus, which continuously outputs NO gas to the patient after starting operation, the pulsed nitric oxide therapeutic apparatus of the present invention adapts to the breathing state of the patient during operation, and only enters NO gas when the patient inhales for NO gas. Inhalation therapy not only avoids the waste of resources caused by the continuous output of NO gas during the patient’s exhalation, but also prevents the release of NO gas into the environment, resulting in excessive production of NO ₂ due to local oxidation, and can also slow down the traditional continuous output of gas to the patient. Discomfort.

Example 2

As shown in FIG. 3, a pulsed nitric oxide therapeutic apparatus of the present invention, the difference between this embodiment and Embodiment 1 is that it further includes a gas pressure monitoring device 12 and a binary flow control valve 13; the gas pressure monitoring device 12 and the binary flow control valve 13 are sequentially installed on the gas pipeline between the proportional valve 4 and the gas transmission device 5 along the airflow direction; the gas pressure monitoring device 12 is connected to the signal input end of the central processing unit 7-1; the binary The flow control valve 13 is connected to the signal output end of the central processing unit 7-1; the control panel is also provided with a binary flow control valve adjustment interface for inputting the opening ratio of the proportional valve 4 and the binary flow control valve 13.

The opening ratio of the proportional valve 4 to the binary flow control valve 13 is 1:1 to 1:10; for example, for a breath of 1 to 10, after the proportional valve 4 is opened once, the binary flow control valve 13 is opened 1 to 10 times. .

The gas pressure monitoring device 12 can be selected from a commercially available gas pressure detector or pressure sensor, the gas flow range is 0-10 L/min, and the accuracy is 0.01 L/min.

work process:

According to the patient's vital sign information transmitted by the vital sign monitoring device or the treatment plan set by the doctor, enter the required NO gas concentration and gas flow, the opening ratio of the proportional valve 4, and the proportional valve 4 and binary flow control in the human-machine interface 7-2 The opening ratio of the valve 13; the patient wears the gas delivery device 5. When starting the work, the NO gas in the NO gas storage tank 1-1 is decompressed by the decompression device 1-2 and then transferred to the gas pipeline. The NO gas concentration monitoring device 9 and the NO ₂ gas concentration monitoring device 10 monitor the gas in the gas pipeline in real time. The concentration of NO gas and NO ₂ gas is transmitted to the electronic control module. When the NO or NO ₂ concentration exceeds the set threshold, the alarm 11 will give an alarm; at this time, the user or medical staff makes the central The processor 7-1 controls the pressure reducing device 1-2 to adjust the inlet pressure to the required outlet pressure to release the alarm; when the gas concentration in the gas pipeline is normal, the NO gas is transmitted to the proportional valve 4 through the gas flow meter 3, and when the patient breathes At the moment of breathing, the respiration sensor 6 senses the patient's breathing, and converts the sensed pressure into a signal received by the central processing unit 7-1 and transmits it to the central processing unit 7-1. The central processing unit 7-1 controls the ratio after receiving this signal. The valve 4 opens the valve according to the set opening ratio, so that the NO gas is transmitted to the gas pressure monitoring device 12 through the gas pipeline. When the gas pressure monitoring device 12 transmits the detected gas pressure to the central processing unit 7-1, when the gas is detected When the pressure value reaches the set pressure threshold, the central processing unit 7-1 controls the binary flow control valve 13 to open quickly and then close (one pulse). At this time, the NO gas is transmitted to the patient by the binary flow control valve 13 through the gas transmission device 5. NO inhalation therapy; when the gas pressure monitoring device 12 detects that the gas pressure value reaches the set pressure threshold again, the central processing unit 7-1 again controls the binary flow control valve 13 to open quickly and then close (second pulse). At this time, NO gas It is transmitted to the patient by the binary flow control valve 13 through the gas transmission device 5, and so on and so forth; when the patient exhales, the respiratory receptor 6 does not respond, at this time, the central processing unit 7-1 controls the proportional valve 4 to close, and NO gas is no longer transmitted. To the patient, until the patient inhales again, the respiratory sensor 6 responds again, and a new round of NO inhalation therapy is performed.

Compared with the existing NO therapeutic apparatus, which continuously outputs NO to the patient after starting the operation, the pulsed nitric oxide therapeutic apparatus of the present invention adapts to the breathing state of the patient during operation, and only enters the NO gas treatment when the patient inhales. It avoids the waste of resources caused by the continuous output of NO gas when the patient exhales, and can alleviate the discomfort caused by the traditional continuous output gas to the patient; By adding a gas pressure monitoring device 12 and a binary flow control valve 13 to the gas pipeline, the pulsed nitric oxide therapeutic apparatus can transmit a set amount of gas flow at one time from the proportional valve 4 of Example 1. The airflow is delivered to the patient, further improving the patient's comfort for NO gas inhalation.

Example 3

In a pulsed nitric oxide therapeutic apparatus of the present invention, the difference between this embodiment and Embodiment 2 is that the gas pressure monitoring device 12 is not provided between the proportional valve 4 and the binary flow control valve 13;

The binary flow control valve adjustment interface can also input the time interval of two adjacent pulses of the binary flow control valve 13, so that after the proportional valve 4 is opened once, the binary flow control valve 13 is opened according to the set pulse time interval 1～ 10 times, that is, pulse 1 to 10 times.

The above are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments, and all technical solutions that belong to the idea of the present invention belong to the protection scope of the present invention. It should be pointed out that for those skilled in the art, some improvements and modifications without departing from the principle of the present invention should be regarded as the protection scope of the present invention.

Claims (10)

1. A pulse type nitric oxide therapeutic apparatus is characterized by comprising a decompression type NO gas supply device (1) and a shell (2);

a gas flow meter (3) and a proportional valve (4) are arranged in the shell (2);

the pressure reduction type NO gas supply device (1) is connected with a gas flowmeter (3) through a gas pipeline;

the gas flow meter (3) is connected with a gas transmission device (5) through a gas pipeline;

the proportional valve (4) is arranged on a gas pipeline between the decompression type NO gas supply device (1) and the gas flowmeter (3),

or on a gas pipeline between the gas flow meter (3) and the gas transmission device (5);

the gas transmission device (5) is worn and connected with a patient and is used for transmitting NO gas;

one end of the respiration receptor (6) is connected with the intubation of the gas transmission device (5), and the other end is connected with the electronic control module;

the gas flow meter (3) and the proportional valve (4) are respectively electrically connected with the electronic control module;

the electronic control module is electrically connected with the power supply module (8).

2. The pulsatile nitric oxide therapeutic apparatus of claim 1, wherein:

the pressure reduction type NO gas supply device (1) comprises a NO gas storage tank (1-1) and a pressure reduction device (1-2);

the NO gas storage tank (1-1) is connected with an inlet pipeline of the pressure reducing device (1-2);

and an outlet pipeline of the pressure reducing device (1-2) is connected with a gas flow meter (3) or a proportional valve (4).

3. The pulsatile nitric oxide therapeutic apparatus of claim 2, wherein: the NO gas storage tank (1-1) is a NO steel cylinder, the volume specification of the NO steel cylinder is 50-20000 ml, and the working pressure specification of the NO steel cylinder is 1-10 MPa.

4. The pulsatile nitric oxide therapeutic apparatus of claim 2, wherein: the pressure reducing device (1-2) is any one of a pressure reducing valve, an electromagnetic valve, an electric valve, a pneumatic valve, a stop valve, a pressure reducer and a flow limiting valve.

5. The pulsatile nitric oxide therapeutic apparatus of claim 1, wherein: the gas transmission device (5) is a nasal catheter or a breathing mask or a tracheal cannula.

6. The pulsatile nitric oxide therapeutic apparatus of claim 2, wherein:

the pulse type nitric oxide therapeutic apparatus also comprises an NO gas concentration monitoring device (9) and NO ₂ A gas concentration monitoring device (10) and an alarm (11);

the NO gas concentration monitoring device (9) and NO ₂ The gas concentration monitoring device (10) is arranged on a gas pipeline in the shell (2) and is respectively used for monitoring the concentration of NO gas and NO in the gas pipeline ₂ The gas concentration;

the alarm (11) is arranged on the shell (2);

the NO gas concentration monitoring device (9) and NO ₂ The gas concentration monitoring device (10) and the alarm (11) are respectively connected with the electronic control module.

7. The pulsatile nitric oxide therapeutic apparatus of claim 6, wherein: the electronic control module comprises a central processing unit (7-1) and a human-computer interaction interface (7-2) which are electrically connected;

the human-computer interaction interface (7-2) is embedded in the shell (2);

the gas flow meter (3), the respiration sensor (6), the NO gas concentration monitoring device (9) and NO ₂ The gas concentration monitoring device (10) is respectively connected with the signal input end of the central processing unit (7-1);

the pressure reducing device (1-2), the proportional valve (4) and the alarm (11) are respectively connected with the signal output end of the central processing unit (7-1);

the power supply module (8) is connected with a power supply interface of the central processing unit (7-1).

8. The pulsatile nitric oxide therapeutic apparatus of claim 7, wherein:

the pulse type nitric oxide therapeutic apparatus also comprises a gas pressure monitoring device (12) and a binary flow control valve (13);

the gas pressure monitoring device (12) and the binary flow control valve (13) are sequentially arranged on a gas pipeline between the proportional valve (4) and the gas transmission device (5) along the gas flow direction;

the gas pressure monitoring device (12) is connected with a signal input end of the central processing unit (7-1);

the binary flow control valve (13) is connected with the signal output end of the central processing unit (7-1).

9. The pulsatile nitric oxide therapeutic apparatus of claim 8, wherein:

the human-computer interaction interface (7-2) comprises a display screen and a control panel which are matched and suitable;

the control panel is provided with an NO concentration input interface, an NO gas flow input interface, a proportional valve adjusting interface, a binary flow control valve adjusting interface and a vital sign parameter input interface;

the NO concentration input interface is used for inputting the required NO gas concentration;

the concentration of the NO gas is 0-100 ppm;

the NO gas flow input interface is used for inputting the required NO gas flow;

the proportional valve adjusting interface is used for inputting the opening proportion of the proportional valve (4);

the opening proportion of the proportional valve (4) is 1:1 to 1:100, respectively;

the gas flow speed controlled by the proportional valve (4) is 0-10L/min;

the binary flow control valve adjusting interface is used for inputting the opening proportion of the proportional valve (4) and the binary flow control valve (13);

the opening ratio of the proportional valve (4) to the binary flow control valve (13) is 1:1 to 1:10;

the vital sign parameter input interface is used for inputting vital sign parameters;

the vital sign parameters include age, gender, height, weight, lung capacity, tidal volume, and pulmonary artery pressure.

10. The pulsatile nitric oxide therapeutic apparatus of claim 1 or 9, wherein: pulsed nitric oxide therapeutic instrument still includes vital sign monitoring devices, vital sign monitoring devices electric connection electronic control module.

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