CN103381281A - Medical guide wire - Google Patents
Medical guide wire Download PDFInfo
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- CN103381281A CN103381281A CN2013101524936A CN201310152493A CN103381281A CN 103381281 A CN103381281 A CN 103381281A CN 2013101524936 A CN2013101524936 A CN 2013101524936A CN 201310152493 A CN201310152493 A CN 201310152493A CN 103381281 A CN103381281 A CN 103381281A
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- tinsel
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Abstract
A medical guide wire comprises a flexible strip-shaped core shaft, a guide wire head end positioned at the head part of the core shaft and a coating layer covering the core shaft and made of flexible material, wherein the guide wire head end is hollow and spindle-shaped and has a smooth surface, and provided with flexible strip-shaped petals; the strip-shaped petals are arranged in the axial direction. The guide wire can buffer the pressure to the cavity passage by the guide wire through self-deformation, lowers the risk of cavity passage punching, and reduces the risk of clinical operation.
Description
Technical field
The present invention relates to medical instruments field, particularly a kind of medical guiding wire for endoscopic surgery.
Background technology
When the catheter apparatus being inserted in the organisms nature tracts such as digestive tract, blood vessel, need this catheter instrumentation seal wire is guided to the target site of organism tube chamber in order to arrive more smoothly the disease position.Seal wire inserts in conduit and uses.In addition, also use seal wire to carry out observation and the disposal of the organism tube chamber of endoscope.During use, seal wire is inserted in the guidewire lumen of endoscope, seal wire instrument guide that endoscope is supporting is to the target location.
The seal wire of mentioning in International Application No. WO 2005044358, its material of main part is all a tinsel with certain toughness and intensity, the point diameter of its seal wire is all generally the ball shape of 1mm left and right, and the front end of seal wire uses soft macromolecular material or ductile metal spring housing in the outside.The shortcoming of this seal wire is: because the natural tract of organism has a lot of gauffers, even front end is coated with flexible material, if the head end of seal wire is inserted into the lowest point of gauffer and is absorbed in the time of can not skidding off in it, if the doctor firmly advances seal wire again, the head end of seal wire is because more carefully being easy to puncture the tract wall, cause perforation, clinical application risk is very large.
Chinese patent application 200380105092.X has disclosed a kind of guide wire for medical use, consisted of by the metal core wire that resin covers by the surface, have and bend to round and smooth curvilinear leading section, the direction extended line of this leading section and seal wire baseline angulation are 40 ~ 70 degree.The shortcoming of this seal wire is, the doctor when using seal wire, is to come repeatedly seal wire to be extracted, inserted according to the feedback of the faint power of seal wire be passed back, until position, seal wire directed overshoot position.Therefore, although the seal wire of head-bent easily enters tract on direction of insertion, when extracting, sweep also easily is hooked into the tract wall, causes tract perforation, the having a big risk of clinical use.
Summary of the invention
The shortcoming that easily causes the tract perforation in order to overcome existing medical guiding wire the invention provides the little medical guiding wire of a kind of tract perforation risk.
Medical guiding wire, comprise and have flexible strip mandrel, be positioned at the seal wire head end of mandrel head and be coated on the clad that mandrel is outer, made by flexible material, it is characterized in that: the seal wire head end is the round and smooth spindle of hollow out and surface, this seal wire head end forms by having flexible bar shaped lobe, and the bar shaped lobe arranges vertically.
Further, the seal wire head end is fixedly connected with mandrel by connector, and clad covers the connecting portion of seal wire head end and mandrel.
Further, be coated with the sleeve pipe of macromolecular material or be wound in the tinsel sleeve pipe of spring tubulose by fine wire on the bar shaped lobe; The lubriation materials such as PTFE that are coated with the lubricant coating of hydrophilic nmature on sleeve pipe or have high-lubricity matter; Bar shaped lobe surface-coated has lubricant coating.
A kind of concrete structure of head end is as follows: described bar shaped lobe is tinsel, and two terminations wiry and mandrel are fixed, and the tinsel middle bent forms the part that contacts with tract.Bending section rounding off wiry.
Connector is sleeve, and mandrel and termination wiry all are socketed in sleeve, and sleeve is by welding or be adhesively fixed mandrel and tinsel.
Quantity wiry is one, perhaps two, and perhaps more than two.
Quantity wiry is two or two when above, and tinsel is angled to be fixedly connected with mandrel.When tinsel is two, two one metal wire quadratures.The position that tinsel intersects can be connected, and can be also disjunct.
The concrete structure of another kind of head end is as follows: described bar shaped lobe is laths of metal, and the seal wire head end has at least two laths of metals, and all laths of metals are from same center to external radiation, laths of metal and center one, and free end and the mandrel of laths of metal are fixed.Laths of metal is stamped and is round and smooth spindle, and this center is the part that contacts with tract.
Laths of metal evenly distributes along the center.
Connector is sleeve, and mandrel and laths of metal all are socketed in sleeve, and sleeve is by welding or be adhesively fixed mandrel and laths of metal.
The concrete structure of another kind of head end is as follows: described bar shaped lobe is tinsel, the seal wire head end comprises at least two one metal wires, the tinsel formation spindle that outwards arches upward, and an end of every one metal wire is fixedly connected with mandrel, the other end and other tinsel are fixed in a bit, and fixing point wiry is round and smooth.
Between tinsel for being welded and fixed or being adhesively fixed.Fixing point becomes round and smooth front end after polishing, this fixing point is as the part that contacts with tract.
The concrete structure of another kind of head end is as follows: the head end of mandrel has the extension, and this extension is as the bar shaped lobe, and free end and the mandrel of extension are fixed, the middle bent of extension.This bending section is as the part that contacts with tract.
This extension is by levigate rear formation of mandrel.Perhaps this extension forms by the mandrel cutting is rear.The diameter of extension is less than or equal to half of axle diameter.Connector is sleeve, extension and connector interference fit.Also can the extension and the head end interference fit of clad, at this moment, the head end of clad is as connector.
In order to make this head end have stereochemical structure, the seal wire head end also has an additional metal silk, and described connector is sleeve, and the two ends of additional metal silk are fixedly connected with connector respectively, the middle bent of additional metal silk, additional metal silk and extension quadrature.
The concrete structure of another kind of head end is as follows: mandrel has extension, and this extension cuts at least two isodiametric lines of formation vertically, and the head end of all lines is fixed in a bit, and fixing point is round and smooth, and the tail end of extension is positioned at clad.The head end interference fit of extension and clad, the head end of clad is as connector.
When head end of the present invention enters in the natural tract of organism, if head end runs into gauffer, because head end is round and smooth, therefore can not cause the damage of tract wall.And, because head end is hollow spindle, therefore, when head end runs into gauffer and during pressurized, deformation can occur head end self, plays the effect of compensator or trimmer pressure, reduce the risk of tract perforation; Simultaneously the head end axial length diminishes, and it is large that radial width becomes, and makes that head end is easier to break away from and enter in normal tract from fold place.In addition, when head end entered in the narrow positions of tract, wire rod is compressive deformation inwardly, makes head end pass through smoothly.
The present invention has and can cushion seal wire to the pressure of tract by self deformation, reduces the risk of tract perforation, reduces the advantage of clinical operation risk.
Description of drawings
Schematic diagram when Fig. 1 is the present invention's process loculus road.
Fig. 2 is the schematic diagram of the present invention when running into the tract gauffer.
Fig. 3 is the schematic diagram of the present invention's head end distortion when running into the tract gauffer.
Fig. 4 is the schematic diagram that the present invention normally enters tract.
Fig. 5 is that the present invention has the schematic diagram that the first head end has an one metal wire.
Fig. 6 is that the present invention has the schematic diagram that the first head end has two one metal wires.
Fig. 7 is that the A-A of Fig. 6 is to schematic diagram.
Fig. 8 is the schematic diagram that the present invention has the second head end.
Fig. 9 is that the B-B of Fig. 8 is to schematic diagram.
Figure 10 is the three valve structure schematic diagrams that the present invention has the third head end.
Figure 11 is that the C-C of Figure 10 is to schematic diagram.
Figure 12 is the pintongs structural representation that the present invention has the third head end.
Figure 13 is that the D-D of Figure 10 is to schematic diagram.
Figure 14 is that the 4th kind of head end of the levigate formation in extension and connector are the schematic diagram of sleeve.
Figure 15 is that the extension cutting forms the 4th kind of head end and connector is the schematic diagram of sleeve.
Figure 16 is that the 4th kind of head end of the levigate formation in extension and connector are the schematic diagram of clad.
Figure 17 is that the extension mill cuts into the 4th kind of head end and connector is the schematic diagram of clad.
Figure 18 is the schematic diagram with the 4th kind of head end of additional metal silk.
Figure 19 is the pintongs structural representation of the 5th kind of head end.
Figure 20 is that the E-E of Figure 19 is to schematic diagram.
Figure 21 is three valve structure schematic diagrams of the 5th kind of head end.
Figure 22 is that the F-F of Figure 20 is to schematic diagram.
The specific embodiment
In conjunction with Fig. 1-7
Medical guiding wire, comprise and have flexible strip mandrel 1, be positioned at the seal wire head end 2 of mandrel 1 head and be coated on the clad 3 that mandrel 1 is outer, made by flexible material, seal wire head end 2 is the round and smooth spindle of hollow out and surface, this seal wire head end 2 forms by having flexible bar shaped lobe, and the bar shaped lobe arranges vertically.Clad 3 can be to be made by macromolecular material, can be also to make as the other materials that bourdon tube etc. has elasticity and a low-friction coefficient.Having of clad 3 is beneficial to the resistance that reduces to push seal wire, makes the doctor obtain better feel.
Seal wire head end 2 is fixedly connected with mandrel 1 by connector 4, and clad 3 covers the connecting portion of seal wire head end 2 and mandrel 1.
Be coated with the macromolecular material sleeve pipe on the bar shaped lobe or be wound in the tinsel sleeve pipe of spring tubulose by fine wire; The lubriation materials such as PTFE that polymer surface is coated with the lubricant coating of hydrophilic nmature or has high-lubricity matter.
This macromolecular material sleeve pipe and outside lubricant coating repaste as TPU and cover hydrophilic coating, perhaps directly apply the PTEE material on the bar shaped lobe.
Can also be wound around the bourdon tube that is coiled into by developing material on the bar shaped lobe.Perhaps add the metal level of one deck good springiness on the bar shaped lobe, as stainless steel spring pipe, platinum bourdon tube etc., with deformation behavior ability and the development effect of enhancing under X-ray that strengthens the seal wire head end.
The concrete structure of head end is as follows: the bar shaped lobe is tinsel 2A, and two terminations wiry and mandrel 1 are fixing, and tinsel 2A middle bent forms the part that contacts with tract A.The bending section rounding off of tinsel 2A.The widest position D that tinsel 2A bending forms afterwards is 1.2mm ~ 2mm.The diameter d of stem stem is 0.5mm ~ 1mm.The length of seal wire head end is 3mm ~ 6mm.
The quantity of tinsel 2A is one, as shown in Figure 5.Perhaps the quantity of tinsel 2A is two, as shown in Figure 6.Perhaps the quantity of tinsel 2A is more than two.
When the quantity of tinsel 2A was one, head end became the obtuse structure on plane, when head end is subject to radially extruding force, can be retracted to minimum diameter, was conducive to the narrow positions by tract.
The quantity of tinsel 2A is two or two when above, and tinsel 2A is angled to be fixedly connected with mandrel.When tinsel 2A is two, as shown in Figure 7, two one metal wire 2A quadratures.The position that tinsel 2A intersects can be connected, and can be also disjunct.When having the tinsel 2A more than two, seal wire head end 2 is three-dimensional shape, and the head end of three-dimensional shape is compared with the head end of flat shape and easilier deviate from from fold place.
When the seal wire head end entered in the natural tract A of organism, if head end runs into gauffer B, therefore the bending section rounding off of tinsel 2A can not cause the damage of tract wall.When head end runs into gauffer B and during pressurized, deformation can occur and present axial length and diminish in tinsel 2A self, and it is large that radial width becomes, and plays the effect of compensator or trimmer pressure, reduces the risk of tract A perforation; Simultaneously tinsel 2A deformation makes head end easier from gauffer B disengaging and enter in normal tract A.In addition, in the time of in head end enters minor diameter tract A, tinsel 2A is compressive deformation inwardly, makes head end pass through smoothly.After tinsel 2A crossed the minor diameter tract, tinsel 2A recovered deformation automatically.
Deformation can occur when head end is obstructed and come compensator or trimmer pressure in seal wire in the present embodiment automatically, has the risk that can reduce the tract perforation, improves the advantage of the safety of clinical operation.
In conjunction with Fig. 8,9
The present embodiment is that from the difference part of embodiment 1 concrete structure of head end is different.Concrete structure is as follows: as shown in Figure 9, the bar shaped lobe is laths of metal 2B, and seal wire head end 2 has at least two laths of metal 2B, and all laths of metal 2B are from same center C to external radiation, laths of metal 2B and center C one, the free end of laths of metal 2B and mandrel 1 are fixing.Laths of metal 2B is stamped and is round and smooth spindle, and this center C is the part that contacts with tract A.Laths of metal 2B evenly distributes along center C.Connector 4 is sleeve, and mandrel 1 and laths of metal 2B all are socketed in sleeve, and sleeve is by welding or be adhesively fixed mandrel 1 and laths of metal 2B.All the other structures are all identical with embodiment 1.
In the present embodiment, adopt integrated laths of metal punching press to form the seal wire head end, head end is more round and smooth, more easily enters the organism tract, avoids damaging the tract wall.Laths of metal can be used as standard component production, can reduce the cost of the manufacturing, and Sheet Metal Forming Technology is simple.
Be the schematic diagram of the pintongs structure when having 4 laths of metals in Fig. 8, the seal wire head end can also be made three valve structures or two valve structures.Wherein ideal with three valve structures, because three valve structures namely are three-dimensional shape, after closing up, compression can obtain best diameter again, more be conducive to the narrow positions by tract.
Figure 10-13
The present embodiment is that from the difference part of embodiment 1 concrete structure of head end is different.Concrete structure is as follows: described bar shaped lobe is tinsel 2C, seal wire head end 2 comprises at least two one metal wire 2C, the tinsel 2C formation spindle that outwards arches upward, the end of every one metal wire 2C is fixedly connected with mandrel 1, the other end and other tinsel 2C are fixed in a bit, and the fixing point of tinsel 2C is round and smooth.All the other structures are all identical with embodiment 1.
Between tinsel 2C for being welded and fixed or being adhesively fixed.Fixing point becomes round and smooth front end after polishing, this fixing point is as the part that contacts with tract A.
Between tinsel 2C welding or be adhesively fixed after need the fixing point grinding process obtaining round and smooth front end, thereby avoid damaging the tract wall.
Be the three valve structure head ends that form when having three one metal wire 2C as shown in FIG. 10 and 11.Figure 12,13 is depicted as the pintongs structure head end that forms when having four one metal wire 2C.Certainly, also can adopt two one metal wire 2C to form the head end of two valve structures.Wherein ideal with three valve structures, because three valve structures namely are three-dimensional shape, after closing up, compression can obtain best diameter again, more be conducive to the narrow positions by tract.
The present embodiment uses welded wire or bonding formation seal wire head end, and tinsel is preshaped is circular arc, then with the fusiform seal wire head end of the fixing formation of tinsel, consumptive material wiry is few, has advantages of the cost of saving.
Figure 14-18
The present embodiment is that from the difference part of embodiment 1 concrete structure of head end is different.Concrete structure is as follows: the head end of mandrel 1 has extension 2D, and this extension 2D is as the bar shaped lobe, and the free end of extension 2D and mandrel 1 are fixing, the middle bent of extension 2D.This bending section is as the part that contacts with tract A.All the other structures are all identical with embodiment 1.
This extension 2D is by levigate rear formation of mandrel 1, as shown in figure 14.Perhaps this extension 2D is by rear the formation as shown in figure 15 of mandrel 1 cutting.The diameter of extension 2D is less than or equal to half of mandrel 1 diameter.Connector 4 is sleeve, and extension 2D and connector 4 interference fit are as shown in Figure 14,15.Also can extension 2D and the head end interference fit of clad 3, at this moment, the head end of clad 3 is as connector 4, as shown in Figure 16,17.
In order to make this head end have stereochemical structure, as shown in figure 18, seal wire head end 2 also has an additional metal silk 2E, described connector 4 is sleeve, the two ends of additional metal silk 2E are fixedly connected with connector 4 respectively, the middle bent of additional metal silk 2E, additional metal silk 2E and extension 2D quadrature.The seal wire head end of stereochemical structure can strut gauffer after head end deformation when running into gauffer, and the seal wire head end of comparing the plane more easily breaks away from gauffer.
In the present embodiment, adopt the extension of mandrel itself to make the seal wire head end, have advantages of that the connectivity robustness of seal wire head end and mandrel is good.
Embodiment 5
Figure 19-22
The present embodiment is that from the difference part of embodiment 1 concrete structure of head end is different.Concrete structure is as follows: mandrel 1 has extension, and this extension cuts at least two isodiametric lines 2F of formation vertically, and the head end of all lines is fixed in a bit, and fixing point is round and smooth, and the tail end of extension is positioned at clad 3.The head end interference fit of extension and clad 3, the head end of clad 3 is as connector 4.All the other structures are all identical with embodiment 1.
The extension that Figure 19,20 is depicted as mandrel is cut into the schematic diagram of the pintongs structure head end of the timesharing such as 4.The extension that Figure 21,22 is depicted as mandrel is cut into the schematic diagram of three valve structure head ends of 3 deciles.Between lines 2F, by welding or being adhesively fixed, fixing point becomes round and smooth front end after polishing, and this fixing point is as the part that contacts with tract A.
Minute cutting such as mandrel extension is formed the seal wire head end, have and need not to weld between seal wire head end and mandrel or bonding etc. fixing, and the advantage that is connected firmly.In this structure, the outer end that only need make clad cover extension gets final product, and need not to set up independent connector, also need not to do welding or bonding processing, simplification of flowsheet.
The described content of this description embodiment is only enumerating the way of realization of inventive concept; protection scope of the present invention should not be regarded as only limiting to the concrete form that embodiment states, protection scope of the present invention also reaches conceives the equivalent technologies means that can expect according to the present invention in those skilled in the art.
Claims (10)
1. medical guiding wire, comprise and have flexible strip mandrel, be positioned at the seal wire head end of mandrel head and be coated on the clad that mandrel is outer, made by flexible material, it is characterized in that: the seal wire head end is the round and smooth spindle of hollow out and surface, this seal wire head end forms by having flexible bar shaped lobe, and the bar shaped lobe arranges vertically.
2. the medical guiding wire as shown in claim 1, it is characterized in that: the seal wire head end is fixedly connected with mandrel by connector, and clad covers the connecting portion of seal wire head end and mandrel.
3. the medical guiding wire as shown in claim 2, it is characterized in that: the bar shaped lobe is coated with flexible layer, flexible layer is for to make sleeve pipe by macromolecular material, this outside of sleeve be coated with lubricant coating or this flexible layer for be wound in the tinsel sleeve pipe of spring tubulose by fine wire; Bar shaped lobe surface-coated has lubricant coating.
4. the medical guiding wire as shown in one of claim 1-3, it is characterized in that: described bar shaped lobe is tinsel, and two terminations wiry and mandrel are fixed, and the tinsel middle bent forms the part that contacts with tract, bending section rounding off wiry.
5. the medical guiding wire as shown in claim 4, it is characterized in that: connector is sleeve, and mandrel and termination wiry all are socketed in sleeve, and sleeve is by welding or be adhesively fixed mandrel and tinsel; Quantity wiry is one, perhaps two, and perhaps more than two.
6. the medical guiding wire as shown in one of claim 1-3, it is characterized in that: described bar shaped lobe is laths of metal, and the seal wire head end has at least two laths of metals, and all laths of metals are from same center to external radiation, laths of metal and center one, free end and the mandrel of laths of metal are fixed.
7. the medical guiding wire as shown in one of claim 1-3, it is characterized in that: described bar shaped lobe is tinsel, the seal wire head end comprises at least two one metal wires, the tinsel formation spindle that outwards arches upward, one end of every one metal wire is fixedly connected with mandrel, the other end and other tinsel are fixed in a bit, and fixing point wiry is round and smooth.
8. the medical guiding wire as shown in one of claim 1-3, it is characterized in that: the head end of mandrel have by mandrel levigate rear form or mandrel cutting after the extension that forms, this extension is as the bar shaped lobe, and free end and the mandrel of extension are fixed, the middle bent of extension.
9. the medical guiding wire as shown in claim 8, it is characterized in that: the seal wire head end also has an additional metal silk, and described connector is sleeve, and the two ends of additional metal silk are fixedly connected with connector respectively, the middle bent of additional metal silk, additional metal silk and extension quadrature.
10. the medical guiding wire as shown in one of claim 1-3, it is characterized in that: mandrel has extension, and this extension cuts at least two isodiametric lines of formation vertically, and the head end of all lines is fixed in a bit, fixing point is round and smooth, and the tail end of extension is positioned at clad.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310152493.6A CN103381281B (en) | 2013-04-27 | 2013-04-27 | Medical guide wire |
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| CN201310152493.6A CN103381281B (en) | 2013-04-27 | 2013-04-27 | Medical guide wire |
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| CN103381281B CN103381281B (en) | 2015-05-20 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106037825A (en) * | 2016-06-16 | 2016-10-26 | 浙江大学医学院附属儿童医院 | Vaginal secretion fetching/medicating cannula device for female children and adolescents |
| CN107865996A (en) * | 2017-07-17 | 2018-04-03 | 杭州启明医疗器械有限公司 | A kind of seal wire |
| WO2019015548A1 (en) * | 2017-07-17 | 2019-01-24 | 杭州启明医疗器械有限公司 | Guide wire |
| CN112245770A (en) * | 2020-11-16 | 2021-01-22 | 勃森生命科技(上海)有限公司 | Guide wire for aortic arch interventional therapy |
| CN113827845A (en) * | 2021-10-22 | 2021-12-24 | 中国医学科学院阜外医院 | Wire guide device with improved supporting effect |
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| US5746692A (en) * | 1994-05-05 | 1998-05-05 | Imagen Medical, Inc. | Catheter and endoscope system with distal protruding ball tip and method |
| CN1241396A (en) * | 1999-03-30 | 2000-01-19 | 凌锋 | Spring ring technology and structure for embolus arterial tumor |
| EP1430839A1 (en) * | 2001-09-28 | 2004-06-23 | Kanji Inoue | Free thrombus capturing tool |
| CN201216801Y (en) * | 2007-06-15 | 2009-04-08 | 奥林巴斯医疗株式会社 | medical equipment |
| CN203425362U (en) * | 2013-04-27 | 2014-02-12 | 王东 | Medical guide wire |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5746692A (en) * | 1994-05-05 | 1998-05-05 | Imagen Medical, Inc. | Catheter and endoscope system with distal protruding ball tip and method |
| CN1241396A (en) * | 1999-03-30 | 2000-01-19 | 凌锋 | Spring ring technology and structure for embolus arterial tumor |
| EP1430839A1 (en) * | 2001-09-28 | 2004-06-23 | Kanji Inoue | Free thrombus capturing tool |
| CN201216801Y (en) * | 2007-06-15 | 2009-04-08 | 奥林巴斯医疗株式会社 | medical equipment |
| CN203425362U (en) * | 2013-04-27 | 2014-02-12 | 王东 | Medical guide wire |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106037825A (en) * | 2016-06-16 | 2016-10-26 | 浙江大学医学院附属儿童医院 | Vaginal secretion fetching/medicating cannula device for female children and adolescents |
| CN107865996A (en) * | 2017-07-17 | 2018-04-03 | 杭州启明医疗器械有限公司 | A kind of seal wire |
| WO2019015548A1 (en) * | 2017-07-17 | 2019-01-24 | 杭州启明医疗器械有限公司 | Guide wire |
| CN107865996B (en) * | 2017-07-17 | 2025-07-01 | 杭州启明医疗器械股份有限公司 | A guide wire |
| CN112245770A (en) * | 2020-11-16 | 2021-01-22 | 勃森生命科技(上海)有限公司 | Guide wire for aortic arch interventional therapy |
| CN113827845A (en) * | 2021-10-22 | 2021-12-24 | 中国医学科学院阜外医院 | Wire guide device with improved supporting effect |
| CN113827845B (en) * | 2021-10-22 | 2025-08-05 | 中国医学科学院阜外医院 | A guide wire device with improved support effect |
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| CN103381281B (en) | 2015-05-20 |
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Address after: 201315 No. 1258, Lane 206, Sau Sau Road, Nanhui District, Shanghai Co-patentee after: Li Zhaoshen Patentee after: Wang Dong Co-patentee after: Hangzhou Angeles Medical Science and Technology Co., Ltd. Address before: 201315 No. 1258, Lane 206, Sau Sau Road, Nanhui District, Shanghai Co-patentee before: Li Zhaoshen Patentee before: Wang Dong Co-patentee before: Hangzhou Anjisi Medical Technology Co., Ltd. |
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Effective date of registration: 20200409 Address after: 311100 Building 597 Kangxin Road, Yuhang District, Hangzhou City, Zhejiang Province, 5 and 6 (except room 103 and 202) Patentee after: Hangzhou Anjisi Medical Science and Technology Co., Ltd. Address before: 201315 No. 1258, Lane 206, Sau Sau Road, Nanhui District, Shanghai Co-patentee before: Li Zhaoshen Patentee before: Wang Dong Co-patentee before: Hangzhou Anjisi Medical Science and Technology Co., Ltd. |