CN102885054A - Sterilization composition containing prothioconazole and prothioconazole - Google Patents
Sterilization composition containing prothioconazole and prothioconazole Download PDFInfo
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- CN102885054A CN102885054A CN2012104332721A CN201210433272A CN102885054A CN 102885054 A CN102885054 A CN 102885054A CN 2012104332721 A CN2012104332721 A CN 2012104332721A CN 201210433272 A CN201210433272 A CN 201210433272A CN 102885054 A CN102885054 A CN 102885054A
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- prothioconazoles
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- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
- 229940058690 lanosterol Drugs 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- XWPZUHJBOLQNMN-UHFFFAOYSA-N metconazole Chemical group C1=NC=NN1CC1(O)C(C)(C)CCC1CC1=CC=C(Cl)C=C1 XWPZUHJBOLQNMN-UHFFFAOYSA-N 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- TVLSRXXIMLFWEO-UHFFFAOYSA-N prochloraz Chemical compound C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl TVLSRXXIMLFWEO-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 description 1
- KKMLIVYBGSAJPM-UHFFFAOYSA-L propineb Chemical compound [Zn+2].[S-]C(=S)NC(C)CNC([S-])=S KKMLIVYBGSAJPM-UHFFFAOYSA-L 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 150000003432 sterols Chemical group 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical group COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 description 1
- BAZVSMNPJJMILC-UHFFFAOYSA-N triadimenol Chemical compound C1=NC=NN1C(C(O)C(C)(C)C)OC1=CC=C(Cl)C=C1 BAZVSMNPJJMILC-UHFFFAOYSA-N 0.000 description 1
- FFSJPOPLSWBGQY-UHFFFAOYSA-N triazol-4-one Chemical compound O=C1C=NN=N1 FFSJPOPLSWBGQY-UHFFFAOYSA-N 0.000 description 1
- AMHNZOICSMBGDH-UHFFFAOYSA-L zineb Chemical compound [Zn+2].[S-]C(=S)NCCNC([S-])=S AMHNZOICSMBGDH-UHFFFAOYSA-L 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a sterilization composition containing prothioconazole and prothioconazole. The sterilization composition comprises active ingredients and pesticide preparation auxiliary components, particularly, the active ingredients are composed of prothioconazole and prothioconazole in a weight ratio of 1:1-40; and the active ingredients are not more than 90% of the weight content of the sterilization composition. According to the sterilization composition, prothioconazole and prothioconazole of different action mechanisms are compounded, and prothioconazole and prothioconazole have remarkable synergistic effects, so that the composition has significant control efficiency, the sterilization range is expanded, the resistance is reduced and delayed, and the toxicity (to mammals) is not increased; and in addition, the composition is small in dosage, low in pharmacy cost and smaller in environmental pollution.
Description
Technical field
The invention belongs to pesticide field, particularly a kind of bactericidal composition for control Cereal banded sclerotial blight, leaf spot, beans stalk break, rust, anthracnose and fruits and vegetables class early blight, late blight, gray mold etc.
Background technology
Prothioconazoles, chemical name is: (RS)-and 2-(2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl)-2,4-dihydro-1,2,4-triazole-3-thioketones is a kind of New-type wide-spectrum triazolinthione series bactericidal agent of Beyer Co., Ltd's development.Former medicine is white crystal, and it is low to have toxicity, without teratogenesis, and without the mutagenesis type, to embryo's avirulence, the advantage such as safe for human and animal and environment.The mechanism of action is the demethylation effect of precursor one lanosterol on methylene lanostenol 14-or 24-position of sterol in the Antifungi, i.e. demethylation inhibitor (DMIs).Prothioconazoles not only has good systemic activity, excellent protection, treats and root out activity, and the lasting period is long.By a large amount of field control effectiveness tests, the result shows that prothioconazoles not only has good safety to crop, and preventing disease theraping effect is good, and volume increase is obvious, compares with triazole bactericidal agent, and prothioconazoles has the more bactericidal activity of wide spectrum.It is mainly used in preventing and treating cereal crop such as numerous diseases such as wheat, barley, rape, peanut, paddy rice and legume crop.Almost all wheat class diseases there is good control efficiency, such as the powdery mildew of Wheat and barley, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc.Can also prevent and treat the soil-borne disease of oily Lay and peanut, such as stalk break, and main foliage disease, such as gray mold, black spot, brown spot, balck shank, stalk break and rust etc.But single dose usage amount and cost are higher, and long-term use can make plant produce resistance, and is also limited to the control efficiency of special crop and different diseases.
At present, have some and carry out composite bibliographical information about prothioconazoles and other bactericide.For example Chinese invention patent application 201110238819.8 discloses a kind of prothioconazoles and triazole bactericidal agent of containing according to the bactericidal composition of 1: 80～80: 1 composition of proportions of weight ratio, wherein active components A is selected from prothioconazoles, active component B is selected from epoxiconazole, a kind of in the own azoles alcohol, said composition is used for preventing and treating powdery mildew, banded sclerotial blight, false smut, leaf spot, rust, stalk break, spot defoliation, gray mold, helminthosporium leaf spot, scab, black spot, brown spot, the diseases such as black rot, it is little to have dosage, resistance of rainwater washing against, synergy significantly acts on.Chinese invention patent application 201110237522.X discloses a kind of bactericidal composition that contains prothioconazoles, the active components A of said composition is selected from prothioconazoles, active component B is selected from thiophanate-methyl, carbendazim, a kind of in the Prochloraz, wherein the weight ratio of active components A and active component B is 1: 80～80: 1, be used for preventing and treating powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, virus disease, anthracnose, gray mold, ring spot, bakanae disease, rice blast, early blight, green mould, blossom-end rot, penicilliosis, helminthosporium leaf spot, scab, the diseases such as damping off, it is little to have dosage, resistance of rainwater washing against, the obvious characteristics of synergy.Also has in addition Chinese invention patent 201110252217.8,201110247843.8,201110245251.2,201110260045.9 and 201110237204.3,201110247597.6 disclose respectively prothioconazoles and the glyoxalin of performance synergistic effect, penconazole, Triadimenol, bitertanol, Cyproconazole, Flusilazole, Flutriafol, triazolone, propiconazole, tetraconazole, alkene azoles alcohol, nitrile bacterium azoles, cyprodinil, mancozeb, Propineb, the bactericidal composition of zineb and Carbatene.
Tpn (English general chlorothalonil by name) is a kind of wide spectrum, protective fungicide; can with the fungal cell in glyceraldehyde 3-phosphate dehydrogenase have an effect; tie mutually entirely with the protein that contains cysteine in this enzyme; thereby destroy this enzymic activity, fungal cell's metabolism is damaged and loses one's life power.Main Function is the prevention fungal infection, does not have interior suction conduction, but at plant surface good adhesivity is arranged, and is not subject to rain drop erosion, and the long drug effect phase is arranged.But because it belongs to conventional sterilization agent kind, the long-term frequent use of large tracts of land has produced serious resistance.Therefore, often rotate use or mix use with other bactericide.At present, the composite report about tpn and other bactericide is very many.For example, Chinese invention patent 200510094381.5 discloses a kind of bactericidal composition and application thereof that contains pyraclostrobin and tpn; This bactericidal composition contains pyraclostrobin and tpn, and wherein pyraclostrobin and tpn weight ratio are 1～30: 1～60; Said composition can be applicable to prevent and treat Cereal, melon and fruit or vegetable crop disease.Chinese invention patent 201110329182.3 discloses a kind of bactericidal composition that contains tpn and triazole class compounds, wherein active component A is selected from tpn, active component B is selected from bitertanol, metconazole, triticonazole, a kind of in kind of bacterium azoles or the RH-7592, wherein the percentage by weight of effective active composition A and B is 1～80%: 1～60%, be used for preventing and treating powdery mildew, gray mold, downy mildew, rice blast, glume blight, rust, anthracnose, spot defoliation, rot, brown rot, scab, leaf spot, epidemic disease, black spot, brown spot, shot hole, leaf blight, it is little to have dosage, resistance of rainwater washing against, synergy significantly acts on.
More than, although in the prior art existing about prothioconazoles with some bactericide carry out composite and tpn carries out the composite example of obtaining notable synergistic with some bactericide, have no about prothioconazoles and tpn and carry out composite report.In addition, existing agriculture chemical compounding patent is mainly all only considered the composite synergistic effect that brings, yet, although synergistic effect is more obvious better, but be not to use unique factor of considering as agricultural chemicals, what also need especially to consider is, toxicity and the problem of environmental pollution of the composition after composite.For example, although some active component uses problem little separately, after the composite use, bad chemical reaction may occur and cause problem of environmental pollution in the intermediate product that produces in their degradation process.Therefore, provide truly have synergistic effect and composite toxicity not to have to increase and bactericidal composition that problem of environmental pollution is less significant.
Summary of the invention
Technical problem to be solved by this invention provides the bactericidal composition that a kind of control efficiency is good, resistance is low, safety is good.
For solving above technical problem, following technical scheme of the present invention:
A kind of bactericidal composition that contains prothioconazoles and tpn, it is comprised of active component and pesticidal preparations auxiliary element, particularly, described active component is comprised of prothioconazoles and tpn 1: 1 by weight ratio～40, and the weight content that active component accounts for bactericidal composition is no more than 90%.
Preferably, described active component is comprised of prothioconazoles and tpn 1: 5 by weight ratio～30.More preferably, active component is comprised of prothioconazoles and tpn 1: 5 by weight ratio～20; Further preferably, active component is comprised of prothioconazoles and tpn 1: 5 by weight ratio～15.When prothioconazoles and tpn are composite according to this ratio, not only reached the most significant synergistic effect, and maximum low, the safe for human and animal and environment advantage of toxicity that has kept the prothioconazoles single dose.Most preferably, active component is comprised of prothioconazoles and tpn 1: 5 by weight ratio～10.
According to the present invention, bactericidal composition can be various formulations, wherein is preferably water dispersible granules and suspending agent.
According to a concrete and preferred aspect of the present invention, bactericidal composition is water dispersible granules, the pesticidal preparations auxiliary element comprises dispersion moisture agent, disintegrant, binding agent and filler, and described dispersion moisture agent is comprised of by weight 1: 0.2～3 modified lignin mahogany sulfonate and ethylene oxide-propylene oxide block copolymer; Described disintegrant is one or more the combination that is selected from sodium chloride, sodium sulphate, ammonium sulfate and the urea, and take the gross weight of bactericidal composition as benchmark, the weight content of above-mentioned each component is as follows: prothioconazoles 1%～15%; Tpn 3%～75%; Dispersion moisture agent 1%～15%, disintegrant 3%～8%, binding agent 1%～5% and filler surplus.
Experiment showed, that the composite effect of prothioconazoles and tpn can farthest be brought into play when bactericidal composition consisted of water dispersible granules with the above-mentioned prescription of the present invention.
When bactericidal composition was water dispersible granules, the weight content that active component preferably accounts for described bactericidal composition was 15%～80%.
In the water dispersible granules, ethylene oxide-propylene oxide block copolymer (PEO-b-PPO) can be by expoxy propane under catalyst action, reacts with the oxirane of some to make, perhaps by commercially available.The number-average molecular weight of preferred ethylene oxide-propylene oxide block copolymer is 2000～3000, and wherein, the percentage composition of PEO in block copolymer is preferably 20%～40%.
In the water dispersible granules, disintegrant preferably by urea be selected from sodium chloride, sodium sulphate and the ammonium sulfate one or more and form by weight 1: 1～15.
In the water dispersible granules, binding agent can be commonly used those, such as gelatin, dextrin, soluble starch, polyethylene glycol etc.
Filler can be commonly used those, the wherein combination of one or more in preferred swelled ground, white carbon, the starch.
A preparation process of water dispersible granules is as follows: first with prothioconazoles, tpn, dispersion moisture agent, disintegrant, the filler premixed of formula ratio, mixed material mixes again, then pulverize through airslide disintegrating mill, material after pulverizing changed over to add water in the kneader and the formula ratio binding agent is mediated, extruder grain is drying to obtain.
According to another concrete aspect of the present invention, bactericidal composition is suspending agent, and described pesticidal preparations auxiliary element comprises dispersion moisture agent, thickener, antifreezing agent and deionized water, and dispersion moisture agent is comprised of Tea Saponin and alkylbenzenesulfonate weight ratio 1: 1～10; Thickener is swelled ground or methylcellulose or the combination of the two; Antifreezing agent is one or more the combination that is selected from ethylene glycol, glycerine, sodium chloride and the urea; Take the gross weight of bactericidal composition as benchmark, the weight content of above-mentioned each component is as follows: prothioconazoles 0.5%～15%; Tpn 3%～75%; Dispersion moisture agent 1%～10%, thickener 1%～5%, antifreezing agent 1%～10% and deionized water surplus.
When bactericidal composition was suspending agent, the weight content that active component preferably accounts for bactericidal composition was 10%～55%.
In the suspending agent, thickener preferably is comprised of by weight 1: 0.2～5 swelled ground and methylcellulose.
Experiment showed, when bactericidal composition consists of suspending agent with the above-mentioned prescription of the present invention that obtain the better performance (suspensibility etc.) except making suspending agent, the composite effect of prothioconazoles and tpn can farthest be brought into play.
A preparation process of suspending agent is as follows: prothioconazoles, tpn, dispersion moisture agent, thickener, antifreezing agent and the deionized water of formula ratio are mixed, adopt high-speed shearing machine to carry out just pulverizing, then change in the serialization sand mill and grind, and get final product.
Composition of the present invention, especially to control Cereal banded sclerotial blight, leaf spot, beans stalk break, rust, anthracnose and fruits and vegetables class early blight, late blight, gray mold etc. have remarkable synergistic effect, can improve preventive effect and are of value to and delay the drug-fast generation of germ.
Because adopt above technical scheme, the present invention compared with prior art has following advantage:
1. the present invention is different with the mechanism of action prothioconazoles and chlorothalonil compound, the two has significant synergistic function, and the composition for preventing and controlling effect is remarkable, and bactericidal range enlarges, and resistance is minimized and delays, and toxicity (to mammal) does not increase; 2. take prothioconazoles and tpn as active ingredient, obtain easily safety and stability, eco-friendly water dispersible granules, suspending agent; 3, present composition dosage is little, and drug cost is low, and environmental pollution is less.
Embodiment
Embodiment 1 prothioconazoles and chlorothalonil compound are to the Toxicity Determination of Botrytis cinerea
1. test method: choose the consistent pepper seedling of growth, every basin 3 young plants, each processing selects 5 basins for the examination seedling.With test atomizer spray, the about 5ml of every basin.Inoculation in 24 hours after the chemicals treatment, adopt the gray mold spore suspension evenly to be seeded on the plant, then Hot Pepper Seedling is put into hot-house culture, carry out state of an illness investigation according to the morbidity grade scale after 15 days, and calculating control efficiency, then calculate concentration EC50 in the inhibition with method of least squares, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
CTC≤80 expression composition performances are antagonism; When 80＜CTC＜120, the expression said composition shows as addition; When CTC 〉=120, the expression said composition shows as synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC50/ reagent agent EC50) * 100
The percentage composition of B in the percentage composition of A+B medicament toxicity index * mixture in theoretical toxicity index (TTI)=A medicament toxicity index * mixture.
Co-toxicity coefficient (CTC)=[actual measurement toxicity index (ATI)/theoretical toxicity index (TTI)] * 100.
2. result of the test is referring to table 1.
Table 1 prothioconazoles and chlorothalonil compound are to the Toxicity Determination result of Botrytis cinerea
| Bactericidal agent (weight ratio) | EC50(μg/ml) | ATI | TTI | Co-toxicity coefficient CTC |
| Tpn | 11.08 | 100.0 | - | - |
| Prothioconazoles | 5.28 | 208.6 | - | - |
| Tpn: prothioconazoles=1: 1 | 5.15 | 214.1 | 152.2 | 140.7 |
| Tpn: prothioconazoles=5: 1 | 4.47 | 248.9 | 116.6 | 213.5 |
| Tpn: prothioconazoles=10: 1 | 4.65 | 238.3 | 109.6 | 217.1 |
| Tpn: prothioconazoles=15: 1 | 4.82 | 225.3 | 107.6 | 209.3 |
| Tpn: prothioconazoles=20: 1 | 5.32 | 208.3 | 105.0 | 198.1.2 |
| Tpn: prothioconazoles=30: 1 | 5.86 | 198.4 | 102.2 | 194.1 |
| Tpn: prothioconazoles=40: 1 | 6.35 | 174.5 | 102.6 | 170.1 |
Can find out from the test result of table 1, triazole bactericidal agent and tpn are composite in specific proportions to have good control efficiency to Botrytis cinerea, prothioconazoles: the tpn weight ratio is that 1: 5～30 o'clock CTC are obviously greater than 190, synergistic effect is remarkable, and particularly, prothioconazoles: the tpn weight ratio is 1: 5～15 o'clock, CTC is greater than 200, in reality is used, can improve preventive effect, reduce dosage, reduce use cost.
Embodiment 2
Present embodiment provides a kind of 30% prothioconazoles chlorothalonil water dispersible granule, content meter by weight, its composition of raw materials is: prothioconazoles 15%, tpn 15%, modified lignin mahogany sulfonate 5%, ethylene oxide-propylene oxide block copolymer (number-average molecular weight 2000～2500, wherein the percentage composition of PEO is 20%～25%) 5%, sodium chloride 3%, urea 1%, ammonium sulfate 2%, polyethylene glycol 3%, starch 18%, bentonite 33%.
The preparation process of water dispersible granules is:, pulverize through airslide disintegrating mill with each the material premixed except polyethylene glycol, mix by prescription again, then change over to and add water in the kneader and polyethylene glycol is mediated, extruder grain is drying to obtain.
The technical indicator of gained water dispersible granules is as follows: suspensibility 〉=90.5%; Wetting time≤30s; Moisture≤2.5%; PH value 6.0～8.0; Dispersed 〉=90%; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤25ml; Particle size range (0.8mm～1.5mm) 〉=97%; 54 ± 2 ℃ of heat are store suspensibility 〉=85% after 30 days.
Embodiment 3
Present embodiment provides a kind of 72% prothioconazoles chlorothalonil water dispersible granule, content meter by weight, its composition of raw materials is: prothioconazoles 12%, tpn 60%, modified lignin mahogany sulfonate 6%, ethylene oxide-propylene oxide block copolymer (number-average molecular weight 2000～2500, wherein the percentage composition of PEO is 30%～35%) 3%, urea 2%, ammonium sulfate 3%, dextrin 1%, polyethylene glycol 1%, starch 3%, bentonite 9%.
The preparation process of water dispersible granules is with embodiment 2.The technical indicator of gained water dispersible granules is as follows: suspensibility 〉=92.5%; Wetting time≤30s; Moisture≤2.0%; PH value 6.0～8.0; Dispersed 〉=91%; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤20ml; Particle size range (0.8mm～1.5mm) 〉=97%; 54 ± 2 ℃ of heat are store suspensibility 〉=88% after 30 days.
Embodiment 4
Present embodiment provides a kind of 72% prothioconazoles chlorothalonil water dispersible granule, content meter by weight, its composition of raw materials is: prothioconazoles 12%, tpn 60%, modified lignin mahogany sulfonate 10%, urea 1%, ammonium sulfate 3%, polyethylene glycol 1%, starch 3%, bentonite 10%.
The preparation process of water dispersible granules is with embodiment 2.The technical indicator of gained water dispersible granules is as follows: suspensibility 〉=80%; Wetting time≤60s; Moisture≤3.0%; PH value 6.0～8.0; Dispersed 〉=75%; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤25ml; Particle size range (0.8mm～1.5mm) 〉=95%; 54 ± 2 ℃ of heat are store suspensibility 〉=75% after 30 days.
Embodiment 5
Present embodiment provides a kind of 72% prothioconazoles chlorothalonil water dispersible granule, content meter by weight, its composition of raw materials is: prothioconazoles 12%, tpn 60%, ethylene oxide-propylene oxide block copolymer (number-average molecular weight 2000～2500, wherein the percentage composition of PEO is 20%～25%) 10%, urea 2%, ammonium sulfate 3%, dextrin 1%, polyethylene glycol 1%, starch 2%, bentonite 9%.
The preparation process of water dispersible granules is with embodiment 2.The technical indicator of gained water dispersible granules is as follows: suspensibility 〉=83%; Wetting time≤60s; Moisture≤3.0%; PH value 6.0～8.0; Dispersed 〉=85%; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤25ml; Particle size range (0.8mm～1.5mm) 〉=95%; 54 ± 2 ℃ of heat are store suspensibility 〉=78% after 30 days.
Embodiment 6
Present embodiment provides a kind of 55% prothioconazoles chlorothalonil water dispersible granule, content meter by weight, its composition of raw materials is: prothioconazoles 5%, tpn 50%, modified lignin mahogany sulfonate 8%, ethylene oxide-propylene oxide block copolymer (number-average molecular weight 2500～3000, wherein the percentage composition of PEO is 30%～35%) 3%, urea 2%, gelatin 2%, sodium sulphate 4%, starch 10%, white carbon 16%.
The preparation method of this water dispersible granules is with embodiment 2.The technical indicator of gained water dispersible granules is as follows: suspensibility 〉=91%; Wetting time≤25s; Moisture≤2.5%; PH value 6.0～8.0; Dispersed 〉=90%; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤20ml; Particle size range (0.8mm～1.5mm) 〉=97%; 54 ± 2 ℃ of heat are store suspensibility 〉=87% after 30 days.
Embodiment 7
Present embodiment provides a kind of 48% prothioconazoles tpn suspending agent, content meter by weight, its composition of raw materials is: prothioconazoles 3%, tpn 45%, Tea Saponin 2%, alkylbenzenesulfonate 5%, swelled ground 3%, methylcellulose 2%, ethylene glycol 5%, sodium chloride 3%, deionized water 32%.
The suspending agent preparation method is as follows: by prescription material is added in the sand milling bucket, stir, adopt high-speed shearing machine to carry out just pulverizing; Then change in the serialization sand mill and grind, and get final product.
The technical indicator of gained suspending agent is as follows: suspensibility 〉=96%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤20ml; Pourability: topple over rear residue≤2.5%, residue after the washing≤0.3%; 54 ± 2 ℃ of heat are store suspensibility 〉=91% after 30 days; 0 ± 2 ℃ of cold storage suspensibility 〉=91.5% after 30 days.
Embodiment 8
Present embodiment provides a kind of 48% prothioconazoles tpn suspending agent, content meter by weight, its composition of raw materials is: prothioconazoles 3%, tpn 45%, Tea Saponin 1%, alkylbenzenesulfonate 6%, swelled ground 3%, methylcellulose 2%, ethylene glycol 5%, sodium chloride 3%, deionized water 32%.
The suspending agent preparation method is with embodiment 7.The technical indicator of gained suspending agent is as follows: suspensibility 〉=95.5%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue after the washing≤0.5%; 54 ± 2 ℃ of heat are store suspensibility 〉=90% after 30 days; 0 ± 2 ℃ of cold storage suspensibility 〉=90% after 30 days.
Embodiment 9
Present embodiment provides a kind of 48% prothioconazoles tpn suspending agent, content meter by weight, its composition of raw materials is: prothioconazoles 3%, tpn 45%, alkylbenzenesulfonate 7%, swelled ground 3%, methylcellulose 2%, ethylene glycol 5%, sodium chloride 3%, deionized water 32%.
The suspending agent preparation method is with embodiment 7.The technical indicator of gained suspending agent is as follows:
Suspensibility 〉=89%; PH value 5.0～8.0; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤25ml; Pourability: topple over rear residue≤5.0%, residue after the washing≤0.5%; 54 ± 2 ℃ of heat are store suspensibility 〉=85% after 30 days; 0 ± 2 ℃ of cold storage suspensibility 〉=83% after 30 days.
Embodiment 10
Present embodiment provides a kind of 48% prothioconazoles tpn suspending agent, content meter by weight, its composition of raw materials is: prothioconazoles 3%, tpn 45%, Tea Saponin 8%, swelled ground 3%, methylcellulose 1%, ethylene glycol 5%, sodium chloride 3%, deionized water 32%.
The suspending agent preparation method is with embodiment 7.The technical indicator of gained suspending agent is as follows: suspensibility 〉=90%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue after the washing≤0.3%; 54 ± 2 ℃ of heat are store suspensibility 〉=85% after 30 days; 0 ± 2 ℃ of cold storage suspensibility 〉=85% after 30 days.
Embodiment 11
Present embodiment provides a kind of 26% prothioconazoles tpn suspending agent, content meter by weight, its composition of raw materials is: prothioconazoles 1%, tpn 25%, Tea Saponin 3%, alkylbenzenesulfonate 6%, swelled ground 5%, glycerine 4%, sodium chloride 6%, deionized water 50%.
The suspending agent preparation method is as follows: by prescription material is added in the sand milling bucket, stir, adopt high-speed shearing machine to carry out just pulverizing; Then change in the serialization sand mill and grind, and get final product.
The technical indicator of gained suspending agent is as follows: suspensibility 〉=95%pH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤25ml; Pourability: topple over rear residue≤3.0%, residue after the washing≤0.5%; 54 ± 2 ℃ of heat are store suspensibility 〉=90% after 30 days; 0 ± 2 ℃ of cold storage suspensibility 〉=90% after 30 days.
Embodiment 12
Present embodiment provides a kind of 41% prothioconazoles tpn suspending agent, content meter by weight, its composition of raw materials is: prothioconazoles 1%, tpn 40%, Tea Saponin 1%, alkylbenzenesulfonate 8%, swelled ground 1%, methylcellulose 3%, glycerine 3%, urea 5%, deionized water 38%.
The suspending agent preparation method is as follows: by prescription material is added in the sand milling bucket, stir, adopt high-speed shearing machine to carry out just pulverizing; Then change in the serialization sand mill and grind, and get final product.
The technical indicator of gained suspending agent is as follows: suspensibility 〉=94.8%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) 〉=98%; Lasting foaming characteristic (behind the 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue after the washing≤0.3%; 54 ± 2 ℃ of heat are store suspensibility 〉=89% after 30 days; 0 ± 2 ℃ of cold storage suspensibility 〉=88% after 30 days.
The bactericidal composition control field tomato early epidemic test of pesticide effectiveness
The bactericidal composition that contains prothioconazoles and tpn to embodiment 2～12 carries out the field tomato early epidemic test of pesticide effectiveness.This test arrangement provides by Jiangsu Qizhou Green Chemical Co., Ltd's research and development for reagent in suburb, Jinhu County, Jiangsu Province, contrast medicament 50% tpn wetting powder (commercial), 25% prothioconazoles missible oil (commercial).
Investigation early blight of tomato disease index before medication, for the first time dispenser in their early stage in the state of an illness initial stage, dispenser in per 7 days is once executed 3 times altogether.After the dispenser 7 days for the third time, 14 days, investigated respectively the early blight of tomato disease index in 30 days and calculated preventive effect.Experimental result is as shown in table 2:
Table 2 bactericidal composition of the present invention is prevented and treated the early blight of tomato field control effectiveness test
As can be seen from Table 2, can effectively prevent and treat early blight of tomato behind prothioconazoles and the chlorothalonil compound, control efficiency all is better than single dose, in the scope of application target crop is had no adverse effects.
The present invention can produce higher synergistic function owing to adopt above-mentioned prescription.Compare with single dose prothioconazoles or tpn control corps diseases, enlarged and prevented and treated the disease scope, delayed drug-fast generation.Obviously improve drug effect, reduced dosage and the spraying times of every mu of use, alleviated peasant burden, promote peasant's increasing both production and income, ensured better agriculture safety in production and protected ecotope.Be applied to agricultural plant chemoproection field, the harm of the germs such as fruit tree, vegetables, wheat, paddy rice is had excellence, efficiently protection and therapeutic action.
The acute toxicity experience of bactericidal composition
Determine that in Toxicity Determination test and field control effectiveness test prothioconazoles tpn bactericidal composition is to Cereal banded sclerotial blight, leaf spot, beans stalk break, rust, anthracnose and fruits and vegetables class early blight, late blight, gray mold etc. have on the basis of excellent preventive effect, have carried out the acute toxicity detection.The result is referring to table 3.
Table 3 present composition the acute toxicity tests
As can be seen from Table 3, the composition that contains prothioconazoles and tpn provided by the invention is not compared increase to acute toxicity and the prothioconazoles single dose of rat, rabbit and cavy with the tpn single dose.Particularly, prothioconazoles: the tpn weight ratio is 1: 1～15 o'clock, and toxicity is minimum, and safety is best.
The present invention can produce higher synergistic function, and composite toxicity does not have increase owing to adopt above-mentioned prescription.Compare with single dose prothioconazoles or tpn control corps diseases, enlarged and prevented and treated the disease scope, delayed drug-fast generation.Obviously improve drug effect, reduced dosage and the spraying times of every mu of use, alleviated peasant burden, promote peasant's increasing both production and income, ensured better agriculture safety in production and protected ecotope.Be applied to agricultural plant chemoproection field, the harm of the germs such as fruit tree, vegetables, wheat, paddy rice is had excellence, efficiently protection and therapeutic action.
Above-described embodiment only is explanation technical conceive of the present invention and characteristics; its purpose is to allow the personage who is familiar with technique can understand content of the present invention and according to this enforcement; can not limit protection scope of the present invention with this; all equivalences that Spirit Essence is done according to the present invention change or modify, and all should be encompassed within protection scope of the present invention.
Claims (10)
1. bactericidal composition that contains prothioconazoles and tpn, it is comprised of active component and pesticidal preparations auxiliary element, it is characterized in that: described active component is made of 1:1 ~ 40 by weight ratio prothioconazoles and tpn, and the weight content that described active component accounts for described bactericidal composition is no more than 90%.
2. the bactericidal composition that contains prothioconazoles and tpn according to claim 1, it is characterized in that: described active component is made of 1:5 ~ 30 by weight ratio prothioconazoles and tpn.
3. the bactericidal composition that contains prothioconazoles and tpn according to claim 2, it is characterized in that: described active component is made of 1:5 ~ 15 by weight ratio prothioconazoles and tpn.
4. the bactericidal composition that contains prothioconazoles and tpn according to claim 3, it is characterized in that: described active component is made of 1:5 ~ 10 by weight ratio prothioconazoles and tpn.
5. the described bactericidal composition that contains prothioconazoles and tpn of each claim in 4 according to claim 1, it is characterized in that: described bactericidal composition is water dispersible granules, described pesticidal preparations auxiliary element comprises dispersion moisture agent, disintegrant, binding agent and filler, and described dispersion moisture agent is comprised of by weight 1:0.2～3 modified lignin mahogany sulfonate and ethylene oxide-propylene oxide block copolymer; Described disintegrant is one or more the combination that is selected from sodium chloride, sodium sulphate, ammonium sulfate and the urea, and take the gross weight of described bactericidal composition as benchmark, the weight content of above-mentioned each component is as follows: prothioconazoles 1%～15%; Tpn 3%～75%; Dispersion moisture agent 1%～15%, disintegrant 3%～8%, binding agent 1%～5% and filler surplus.
6. the bactericidal composition that contains prothioconazoles and tpn according to claim 5, it is characterized in that: the weight content that described active component accounts for described bactericidal composition is 15% ~ 80%.
7. the bactericidal composition that contains prothioconazoles and tpn according to claim 5 is characterized in that: described disintegrant by urea be selected from sodium chloride, sodium sulphate and the ammonium sulfate one or more and form by weight 1:1 ~ 15.
8. the described bactericidal composition that contains prothioconazoles and tpn of each claim in 4 according to claim 1, it is characterized in that: described bactericidal composition is suspending agent, described pesticidal preparations auxiliary element comprises dispersion moisture agent, thickener, antifreezing agent and deionized water, and described dispersion moisture agent is comprised of by weight 1:1～10 Tea Saponin and alkylbenzenesulfonate; Described thickener is swelled ground or methylcellulose or the combination of the two; Described antifreezing agent is one or more the combination that is selected from ethylene glycol, glycerine, sodium chloride and the urea; Take the gross weight of described bactericidal composition as benchmark, the weight content of above-mentioned each component is as follows: prothioconazoles 0.5%～15%; Tpn 3%～75%; Dispersion moisture agent 1%～10%, thickener 1%～5%, antifreezing agent 1%～10% and deionized water surplus.
9. the bactericidal composition that contains prothioconazoles and tpn according to claim 8, it is characterized in that: the weight content that described active component accounts for described bactericidal composition is 10% ~ 55%.
10. the bactericidal composition that contains prothioconazoles and tpn according to claim 8 is characterized in that: described thickener preferably is comprised of by weight 1:0.2 ~ 5 swelled ground and methylcellulose.
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| EP3403504A1 (en) * | 2017-05-16 | 2018-11-21 | Rotam Agrochem International Co., Ltd | Fungicidal composition containing prothioconazole and chlorothalonil |
| CN111642503A (en) * | 2013-11-26 | 2020-09-11 | Upl 有限公司 | Method for controlling rust |
| IT201900014445A1 (en) * | 2019-08-08 | 2021-02-08 | Sipcam Oxon S P A | FUNGICIDE COMPOSITION |
| CN112834683A (en) * | 2021-01-08 | 2021-05-25 | 青岛谱尼测试有限公司 | Method for detecting prothioconazole in compound pesticide preparation |
| CN114052030A (en) * | 2017-03-07 | 2022-02-18 | Upl有限公司 | Fungicidal combinations |
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| CN102640748A (en) * | 2012-04-12 | 2012-08-22 | 广西田园生化股份有限公司 | Ultra-low-volume liquid containing prothioconazole |
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| CN111642503A (en) * | 2013-11-26 | 2020-09-11 | Upl 有限公司 | Method for controlling rust |
| EP4014738B1 (en) | 2013-11-26 | 2024-10-30 | UPL Ltd | A method for controlling rust |
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| IT201900014445A1 (en) * | 2019-08-08 | 2021-02-08 | Sipcam Oxon S P A | FUNGICIDE COMPOSITION |
| RU2820219C2 (en) * | 2019-08-08 | 2024-05-31 | Сипкам Оксон С.П.А. | Fungicidal composition |
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| CN112834683A (en) * | 2021-01-08 | 2021-05-25 | 青岛谱尼测试有限公司 | Method for detecting prothioconazole in compound pesticide preparation |
| CN114586777A (en) * | 2021-10-18 | 2022-06-07 | 南京林业大学 | A kind of prothioconazole and chlorothalonil compound water dispersible granules and preparation method thereof |
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