CN102784363B

CN102784363B - Traditional Chinese medicine composition for treating pancreatic cancer and preparation method thereof

Info

Publication number: CN102784363B
Application number: CN2012103061898A
Authority: CN
Inventors: 史德功; 陈爱美; 郭巍; 陈静; 陈晓阳
Original assignee: 史德功
Current assignee: Shi Degong
Priority date: 2012-08-17
Filing date: 2012-08-17
Publication date: 2013-11-27
Anticipated expiration: 2032-08-17
Also published as: CN102784363A

Abstract

The invention provides a traditional Chinese medicine composition for treating the pancreatic cancer and a preparation method of the traditional Chinese medicine composition. The medicinal raw materials of the traditional Chinese medicine composition are as follows: herba sarcandrae, zaocys dhumnade, scutellariae barbatae, Chinese lobelia, oldenlandia diffusa, taraxacum mongolicum, herba violae, herba patriniae, flos lonicerae, fructus forsythiae, radix glycyrrhiza, herba lophatheri, herba artemisiae scopariae, codonopsis pilosula, fructus gardeniae, rheum officinale, semen coicis, caulis sargentodoxae, fructus mume, borneol, christina loosestrife herb, polyporus umbellatus, fructus galangae, radix curcumae longae, rhizoma acori graminei, fructus lycii, rhizoma belamcandae, radix paeoniae rubra and radix trichosanthis. The traditional Chinese medicine composition provided by the invention can be separately utilized or matched up with radiotherapy and chemotherapy, and have the effects of reducing the lumps in a short period and effectively controlling the metastatic spread of cancer cells; and moreover, the traditional Chinese medicine composition is capable of strengthening the immunologic function of the organisms so as to achieve the aims of inhibiting the growth of the cancer cells, being free of side effects simultaneously, enhancing the immunity of the organisms while treating and resisting the cancers, alleviating the pain of the patients, stabilizing the state of the illness, prolonging the life cycle and increasing the proportion of clinically treating the patients.

Description

A kind of Chinese medicine composition for the treatment of cancer of pancreas and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, relate in particular to a kind of Chinese medicine composition that is used for the treatment of cancer of pancreas and preparation method thereof.

Background technology

Cancer of pancreas is more rare in malignant tumor of digestive tract, is more common in 40～60 years old, and the man is more than the female, and cancer of pancreas mostly occurs at Diseases In Pancreatic Head, and only minority occurs in body of pancreas and tail of pancreas section.Cancer of pancreas is due to the position of cancerous protuberance generation and the morning and evening difference of the course of disease, and clinical symptoms is different.The symptom of stomachache for occurring the earliest, be more common in body of pancreas and tail of pancreas section, large multidirectional lower back radiation.The state of an illness can have jaundice in evolution, abdominal mass can appear in late period, heating, and supraclavicular lymph nodes is modal metastasis site.Modern medicine thinks that primary disease may be relevant with chronic pancreatic diseases with carcinogen in environment, coffee, smoking.Cancer of pancreas is a kind of comparatively dangerous malignant tumor, although in every 20,000 people of China, nearly 1 people suffers from cancer of pancreas, should the fast-growth case fatality rate of disease high.The NIH report, 1 year survival rate of cancer of pancreas is 8%, 5 year survival rate 3%.5 years survival rates of China's Statistical data are 5% left and right only.Sickness rate significantly rises year by year in recent years, and U.S.'s cancer of pancreas sickness rate raise 3 times between 10 years, neopathy 43140 examples in 2010, and dead 36800 examples, occupy the tenth of Incidence, and mortality rate but is in the 4th.China's cancer of pancreas morbidity and death toll ascendant trend be highly significant especially, and nearly 20 annual morbidities increase approximately 6 times.According to 38 registry, whole nation tumor registration data in 2007, the cancer of pancreas morbidity occupies the 7th of malignant tumor, and case fatality rate occupies the 6th of malignant tumor.

The total pathogenesis of cancer of pancreas is that weakness of the spleen and stomach, depression of liver-QI cause the stagnation of QI, blood stasis, damp and hot for suffering from, and forms for a long time hard piece.Carcinoma of head of pancreas shows as manyly with damp and hot, and body of pancreas, carcinoma of tail of pancreas be the card of the common insufficiency of the spleen stagnation of QI.The treatment in cancer of pancreas late period should or be attacked or mend or reinforcement and elimination in combination according to the disease different phase.

Cancer of pancreas be take operative treatment in early days as main, and postoperative suitable chemotherapy, in conjunction with long-term Chinese medicine, likely obtains good efficacy; Many operations palliative treatments in mid-term, as unresectable, feasible cholecystojejunostomy to be to alleviate jaundice, Chinese medicine simultaneously, but also Combined with Radiotherapy, chemotherapy etc.; Chinese medicine and symptomatic treatment take late period as main, or in conjunction with small dose chemotherapy.The method of heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, regulating qi-flowing for strengthening spleen is adopted in cancer of pancreas Chinese traditional treatment in late period more.

Cancer of pancreas belongs to the categories such as the traditional Chinese medical science " fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times ", " mass in the abdomen ", " jaundice ", " gathering ", its cause of disease, pathogenesis are mainly internal injury caused by excess of seven emotions, eating and drinking without temperance and cause that the liver spleen is impaired, internal organs are become estranged, turbid damp blocks, qi depression to blood stasis, with the passing of time form primary disease, at " interior warp ", also early have recognized that the relation of primary disease and diet delicious food and jaundice, as " the logical deficiency and excess opinion of commenting of Plain Questions ", say: " fullness caused by stagnant QI is sent out contrary for diseases due to endogenous heat of ZANG FU organs sudden falling down, hemiplegia flaccidity with cold limbs; sweet fertile high official, and the disease of Sorghum vulgare Pers. also ".The traditional Chinese medical science thinks that primary disease is many by depression of liver-QI, due to functional activity of QI being not smooth, insufficiency of the spleen for a long time, insufficiency of the spleen resulting in production of dampness, and strongly fragrant and heat-transformation, with the passing of time delay, causes qi depression to blood stasis, knot in pyretic toxicity.Therefore the methods such as depressed liver-energy dispersing and function of gallbladder promoting, blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, removing mass eliminating stagnation that adopt in treatment more.

The cancer of pancreas early symptom also is not true to type, often show as the symptom that is similar to the other organs pathological changes, cause some Symptomatic by sing misdiagnosis and mistreatment, great majority are diagnosed as the cancer of pancreas, and the person has been metastasis or to the advanced pancreatic cancer of metastasis sign, but doctor trained in Western medicine can only be operation, radiotherapy, chemotherapy to cancer of pancreas treatment of late stage poor effect, cut again and cut, until life finishes, patient spends always in misery, only have less than 20% patient to exist radical operation to wish.Most of Pancreas cancer patients there will be the symptoms such as weight loss, stomachache, jaundice, appetite be poor, epigastric discomfort, abdominal distention, weak symptom can occur in half left and right patient, about twenty percent patient has lumbago and backache, diarrhoea, melena, and losing weight is the most common symptom of Pancreas cancer patients.The early stage patient cardinal symptom is that epigastric discomfort, appetite are poor, abdominal distention, weak, may be middle and advanced stage in case weight loss, stomachache, jaundice occur point out.The traditional Chinese medical science claims that pancreas is that spleen is long-pending, and pancreas jaundice, stomachache are all caused by insufficiency of the spleen.At present, clinical many single method treatment advanced pancreatic cancer that do not adopt, adopt the Chinese medicine integrated approach more, to control to greatest extent the evolution of tumor, alleviate patient's misery, improve quality of life of patients, extend patients ' lives.

Summary of the invention

Technical problem to be solved by this invention is, utilize the traditional theory of Chinese medical science of China, provide that a kind of side effect is little, good effect, cost are low, have no drug resistance, alleviate patient's misery, improve quality of life of patients, extend the Chinese medicine composition and preparation method thereof of the treatment cancer of pancreas of patients ' lives.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of cancer of pancreas, its raw medicinal material comprises: Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Violae, Herba Patriniae, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Herba Artemisiae Scopariae, Radix Codonopsis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Borneolum Syntheticum, Herba Lysimachiae, Polyporus, Fructus Galangae, Rhizoma Curcumae Longae, Rhizoma Acori Graminei, Fructus Lycii, Rhizoma Belamcandae, Radix Paeoniae Rubra and Radix Trichosanthis.

The ratio of weight and number of the raw medicinal material in described Chinese medicine composition is: Herba Sarcandrae 20～35 weight portions, Zaocys 8～15 weight portions, Herba Scutellariae Barbatae 12～15 weight portions, Herba Lobeliae Chinensis 15～30 weight portions, Herba Hedyotidis Diffusae 20～30 weight portions, Herba Taraxaci 30～50 weight portions, Herba Violae 25～40 weight portions, Herba Patriniae 18～30 weight portions, Flos Lonicerae 35～50 weight portions, Fructus Forsythiae 10～20 weight portions, Radix Glycyrrhizae 20～35 weight portions, Herba Lophatheri 20～30 weight portions, Herba Artemisiae Scopariae 15～25 weight portions, Radix Codonopsis 16～34 weight portions, Fructus Gardeniae 15～20 weight portions, Radix Et Rhizoma Rhei 10～15 weight portions, Semen Coicis 20～40 weight portions, Caulis Sargentodoxae 15～30 weight portions, Fructus Mume 20～35 weight portions, Borneolum Syntheticum 25～30 weight portions, Herba Lysimachiae 15～25 weight portions, Polyporus 20～35 weight portions, Fructus Galangae 20～45 weight portions, Rhizoma Curcumae Longae 15～20 weight portions, Rhizoma Acori Graminei 10～15 weight portions, Fructus Lycii 25～35 weight portions, Rhizoma Belamcandae 18～25 weight portions, Radix Paeoniae Rubra 15～25 weight portions and Radix Trichosanthis 30～50 weight portions.

The ratio of weight and number of the raw medicinal material in described Chinese medicine composition also can be more preferably: Herba Sarcandrae 25～30 weight portions, Zaocys 10～15 weight portions, Herba Scutellariae Barbatae 12～15 weight portions, Herba Lobeliae Chinensis 15～20 weight portions, Herba Hedyotidis Diffusae 20～25 weight portions, Herba Taraxaci 30～40 weight portions, Herba Violae 30～35 weight portions, Herba Patriniae 20～25 weight portions, Flos Lonicerae 35～45 weight portions, Fructus Forsythiae 15～20 weight portions, Radix Glycyrrhizae 20～30 weight portions, Herba Lophatheri 20～25 weight portions, Herba Artemisiae Scopariae 15～20 weight portions, Radix Codonopsis 20～30 weight portions, Fructus Gardeniae 15～20 weight portions, Radix Et Rhizoma Rhei 10～15 weight portions, Semen Coicis 20～30 weight portions, Caulis Sargentodoxae 15～25 weight portions, Fructus Mume 20～30 weight portions, Borneolum Syntheticum 28～30 weight portions, Herba Lysimachiae 20～25 weight portions, Polyporus 30～35 weight portions, Fructus Galangae 30～40 weight portions, Rhizoma Curcumae Longae 15～28 weight portions, Rhizoma Acori Graminei 10～12 weight portions, Fructus Lycii 30～35 weight portions, Rhizoma Belamcandae 20～25 weight portions, Radix Paeoniae Rubra 20～25 weight portions and Radix Trichosanthis 30～40 weight portions.

The ratio of weight and number of the raw medicinal material in described Chinese medicine composition again can be more preferably: Herba Sarcandrae 28 weight portions, Zaocys 12 weight portions, Herba Scutellariae Barbatae 15 weight portions, Herba Lobeliae Chinensis 15 weight portions, Herba Hedyotidis Diffusae 22 weight portions, Herba Taraxaci 35 weight portions, Herba Violae 32 weight portions, Herba Patriniae 23 weight portions, Flos Lonicerae 40 weight portions, Fructus Forsythiae 18 weight portions, Radix Glycyrrhizae 25 weight portions, Herba Lophatheri 20 weight portions, Herba Artemisiae Scopariae 15 weight portions, Radix Codonopsis 26 weight portions, Fructus Gardeniae 15 weight portions, Radix Et Rhizoma Rhei 15 weight portions, Semen Coicis 25 weight portions, Caulis Sargentodoxae 20 weight portions, Fructus Mume 30 weight portions, Borneolum Syntheticum 30 weight portions, Herba Lysimachiae 20 weight portions, Polyporus 30 weight portions, Fructus Galangae 35 weight portions, Rhizoma Curcumae Longae 20 weight portions, Rhizoma Acori Graminei 10 weight portions, Fructus Lycii 35 weight portions, Rhizoma Belamcandae 25 weight portions, Radix Paeoniae Rubra 20 weight portions and Radix Trichosanthis 35 weight portions.

The raw medicinal material of described Chinese medicine composition can further include Poria 15～20 weight portions, Radix Ginseng 25～35 weight portions and the Rhizoma Atractylodis Macrocephalae 20～30 weight portions; Be preferably: Poria 18 weight portions, Radix Ginseng 30 weight portions and the Rhizoma Atractylodis Macrocephalae 25 weight portions.

The present invention also provides a kind of preparation method of above-mentioned Chinese medicine composition, and the dosage form of described Chinese medicine composition is for containing tablet, and it comprises the following steps,

The first step, by Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Acori Graminei, with Radix Trichosanthis, mix in described ratio, use the dissolve with ethanol with respect to the determining alcohol 90%～95% of 4～6 times of the mixture quality obtained, reflux was extracted after 2～4 hours, filter, filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtained again, reflux was extracted after 1～2 hour again, filter, merge filtrate twice, decompression recycling ethanol to be concentrated into liquor strength be 0.8～1.2g crude drug/mL, above-mentioned filtrate is the macroporous adsorptive resins of 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90%～95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, drying also is ground into powder,

Second step, Rhizoma Belamcandae, Radix Paeoniae Rubra, Herba Violae, Herba Patriniae, Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Herba Lysimachiae and Polyporus are mixed in described ratio, the alcohol heating reflux added with respect to the determining alcohol 85%～95% of 3～5 times of the mixture quality obtained extracts 2 times, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity was evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density was 1.20～1.23 mastic, and the mastic after concentrated is dried to powder with spray dryer;

The 3rd step, the surplus stock medical material is mixed in described ratio, add the water dissolution of 2～5 times with respect to the mixture quality obtained, heating decocted 2～4 hours, filtered, filtering residue is used to the water dissolution of 1～3 times with respect to the mixture quality obtained again, heating decocted 1～2 hour again, filtered, and merged filtrate, concentrating under reduced pressure is removed moisture, and drying also is ground into powder;

The 4th step, three kinds of powder that obtain are previously mixed, further add with respect to the carboxymethyl starch sodium of 0.05～0.1 times of the mixture quality obtained, the microcrystalline Cellulose of 0.05～0.1 times, mix, granulate, after drying, granulate, add the magnesium stearate with respect to 0.01～0.05 times of the mixture quality obtained, then with decompressor by the granule compacting in flakes, must contain tablet.

The present invention provides again a kind of preparation method of above-mentioned Chinese medicine composition, and the dosage form of described Chinese medicine composition is syrup, and it comprises the following steps,

The first step, by Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Acori Graminei, with Radix Trichosanthis, mix in described ratio, use the dissolve with ethanol with respect to the determining alcohol 85%～95% of 3～5 times of the mixture quality obtained, reflux was extracted after 2～4 hours, filter, filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtained again, reflux was extracted after 1～2 hour again, filter, merge filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8～1.2g crude drug/mL, above-mentioned filtrate is the macroporous adsorptive resins of 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90%～95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, drying also is ground into powder,

Second step, Rhizoma Belamcandae, Radix Paeoniae Rubra, Herba Violae, Herba Patriniae, Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Herba Lysimachiae and Polyporus are mixed in described ratio, the alcohol heating reflux added with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtained extracts 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity was evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density was 1.20～1.23 mastic, and the mastic after concentrated is dried to powder with spray dryer;

The 3rd step, the surplus stock medical material is mixed in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtained, heating decocted 2～4 hours, filtered, filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtained again, heating decocted 1～2 hour again, filtered, and merged filtrate, concentrating under reduced pressure is removed moisture, and drying also is ground into powder;

The 4th step, three kinds of powder that obtain are above mixed, add the water dissolution with respect to 1.5～2 times of mixture qualities, with 40% sodium hydroxide solution, regulate pH value to 7.0, stir evenly, cold preservation is 48 hours～72 hours under 4 ℃～8 ℃ conditions, filter, filtrate adds the sucrose with respect to 0.2～0.4 times of the mixture quality obtained, and stirs and dissolves, and regulates pH value to 7.0, add water appropriate, stir, static 12～18 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.2g/mL～1.5g/mL.

The present invention provides a kind of preparation method of above-mentioned Chinese medicine composition again, and the dosage form of described Chinese medicine composition is capsule, and it comprises the following steps,

The first step, be mixed in proportion described raw medicinal material, puts into marmite and fried 20 minutes～40 minutes, is ground into smalls with pulverizer, is screened into 100 orders～200 purpose powder;

Second step, the determining alcohol that adds 2～4 times of the powder qualities that obtain with respect to the first step is 70～80% ethanol, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, filter the medicinal residues that obtain and add again the distilled water with respect to 4～8 times of filtering residue quality, the each decoction 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate obtains water extraction liquid, water extraction liquid concentrating under reduced pressure, with the concentrated solution of the alcohol extract obtained previously, mix, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract,

The 3rd step, be broken into 200 orders～400 purpose powder by described dried cream powder, in the powder obtained, adds excipient, disintegrating agent mixing, dry, pulverizing, adds fluidizer, in finally incapsulating, obtains capsule;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10～50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5～20%;

Described fluidizer is that magnesium stearate, differential silica gel or other have the pharmaceutic adjuvant of fluidizer effect, and its weight content in described capsule is 0.1～5%.

Beneficial effect of the present invention:

Chinese medicine composition provided by the invention, can use separately, also can the Combined with Radiotherapy chemotherapy use, utilize the traditional theory of Chinese medical science of China, clinical practice is in the treatment of cancer of pancreas, its effect can be dwindled lump in a short time, effectively control the cancer cell metastasis diffusion, anticancer growth, do not have side effects again simultaneously, for cancer anticancer in, enhancing human body immunity power, and the purpose that alleviates the patient suffering, stablizes the state of an illness, extends life cycle and increase clinical cure patient's ratio, and can prevent that remaining cancerous cell from staging a comeback, and reduces relapse and metastasis greatly.

The specific embodiment

The invention provides a kind of Chinese medicine composition for the treatment of cancer of pancreas, its raw medicinal material comprises: Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Violae, Herba Patriniae, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Herba Artemisiae Scopariae, Radix Codonopsis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Borneolum Syntheticum, Herba Lysimachiae, Polyporus, Fructus Galangae, Rhizoma Curcumae Longae, Rhizoma Acori Graminei, Fructus Lycii, Rhizoma Belamcandae, Radix Paeoniae Rubra and Radix Trichosanthis.

Herba Sarcandrae: be the dry herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Summer, Qiu Erji gather, and remove impurity, shine in.Another name: Herba Pileae Scriptae, Herba Pileae Scriptae, synthetism lotus, Vanda amesiana Reichb. F.Bitter in the mouth, suffering, property is flat.GUIXIN, Liver Channel.Clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.For heat in blood, send out speckle dermexanthesis, rheumatic arthralgia, traumatic injury.Cure mainly pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor etc.

Zaocys: another name: Zaocys, black Serpentis, sword ridge Serpentis, reshahar Serpentis, yellowish glaucoma Serpentis, sword ridge Zaocys, southern Serpentis.Sweet in the mouth, property is flat.Return Liver Channel.Dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.

Herba Scutellariae Barbatae: another name: and the head grass, Herba Scutellariae Darbatae, Herba Carpesii Cernui, Aleuritopteris argentea (Gmel.) Fee, purple connect careless demifacet flower, and head is careless partially, small size India skullcap, tiger stings red, aftergrass, Herba hyperici attenuati etc.Acrid in the mouth, hardship; Cold in nature.Return lung meridian, Liver Channel, kidney channel.Heat-clearing and toxic substances removing; The dissipating blood stasis hemostasis; Inducing diuresis to remove edema.Cure mainly the pyretic toxicity carbuncle, have sore throat, lung abscess, acute appendicitis, scrofula, venom, traumatic injury, haematemesis, epistaxis, stranguria with blood, edema, jaundice, ascites and cancer.

Herba Lobeliae Chinensis: have another name called anxious separate that rope, half ray flower, Herba Lobeliae Chinensis, edible kernel of melon seeds grass, snake are careless, Herba Hedyotidis Diffusae etc.Acrid in the mouth, property is flat; GUIXIN, lung, small intestine meridian.Heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Cure mainly: venom, carbuncle furuncle, tonsillitis, eczema, tinea pedis, traumatic injury, jaundice due to damp-heat, appendicitis, enteritis, nephritis, cirrhotic ascites and kinds cancer.

Herba Hedyotidis Diffusae: be again Herba Hedyotidis Diffusae, tongue house steward, Herba Otteliae Alismoidis, sharp knife grass, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia.Mildly bitter flavor, sweet, cold in nature.Enter stomach, large intestine, small intestine meridian, have heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen, for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, the furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, the cards such as cancerous protuberance, often utilize the Herba Hedyotidis Diffusae anticancer, and it has certain radiation resistance.

Herba Taraxaci: contain the multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in the Herba Taraxaci plant, the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting are arranged.Herba Taraxaci contains protein, fat, carbohydrate, trace element and vitamin etc. simultaneously, and abundant nutritive value is arranged, raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Sweet in the mouth, micro-hardship, cold in nature.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Cure mainly upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder is assisted inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection etc.

Herba Violae: bitter in the mouth, suffering, cold in nature.GUIXIN, Liver Channel.Heat-clearing and toxic substances removing, the removing heat from blood detumescence.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.

Herba Patriniae: have another name called that Herba Patriniae, Patrinia scabiosaefolia Fisch, imperial bud Herba Patriniae, patrima villosa, pool lose, Herba Setariae Plicatae, Chinese cabbage, Herba Sonchi Oleracei, maiden spend etc.Acrid in the mouth, hardship, be slightly cold.Return liver, stomach, large intestine channel.Heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing.Cure mainly acute appendicitis, the high heat of lung abscess, cough vomiting bloody pus, pyretic toxicity skin ulcer furuncle, and furuncle is bitterly swollen, breast abdomen pain, appendicitis, enteritis, dysentery, puerperal abdonimal pain, dysmenorrhea etc.

Flos Lonicerae: have another name called Radix Ophiopogonis, Flos Lonicerae, JINHUA, Flos Lonicerae, Flos Lonicerae, close Flos Lonicerae, Flos Lonicerae, two bud flowers, two precious flowers, golden rattan, Soviet Union's flower, little egret flower, between exerting, exert stone roller, hang slope glue appearance, glue is all run (the Dong nationality's name), the hot horse weeding hoe of lamb (Bouyei's Praenomen), my Ta Menggenqiqige (Meng ethnic group's name), throwing is pinched, the moon people's air defense, diligent wall, beautiful parent shines, and qin is sternly flat, kind so effect (Yao nationality's name).Sweet in the mouth, cold in nature.Return lung, the heart, stomach warp.The heat-clearing and toxic substances removing eliminating carbuncle, the loose expelling pathogenic factors from the exterior of a surname, eliminating pathogenic heat from blood to cure dysentery.For the carbuncle furuncle, affection due to external wind and heat, toxic-heat and blood stasis, dysentery pus and blood etc.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold fragrance of its property, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, kind removing summer-heat blood poison also, and for various febrile diseases, as fever of the body, dermexanthesis, send out the cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.

Fructus Forsythiae: bitter in the mouth, cold nature; Enter lung, the heart, small intestine meridian; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, the puckery pain of pyretic stranguria, laryngopharynx swelling and pain, macule, carbuncle pyogenic infections from tumour or sore, acute nephritis, jaundice, the cards such as intestinal twinge, Fructus Forsythiae is inhibited to various bacteria, and human body is had to cooling effect, and obvious antiinflammatory action is arranged.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Heat-clearing and toxic substances removing is arranged, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, be mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, by adding Radix Glycyrrhizae can play QI invigorating neutralization, be in harmonious proportion the effect of each raw medicinal material, the Radix Glycyrrhizae Yiqi and vein recovery, with Radix Ginseng etc., share for throbbing with fear according to one's conscience, through modern pharmacological research, the glycyrrhizic acid that Radix Glycyrrhizae contains can strengthen Detoxication and the resistance of cell, has the antiulcer effect.

Herba Lophatheri: have another name called Rhizoma lophantheri, Gallus jabouillei rice, golden pheasant rice, Herba Lophatheri, Folium Bambosae.Sweet, light, cold.GUIXIN, stomach, small intestine meridian.Clearing away heat-fire, relieving restlessness is quenched the thirst, inducing diuresis for treating stranguria syndrome.For the calentura excessive thirst, the puckery pain of oliguria with reddish urine, aphtha of the mouth and tongue.Cure mainly: in the heart disease heat, cough with dyspnea, haematemesis, pyretic toxicity wind, only quench one's thirst, press borax poison, expectorant, control fanatical unhappiness, apoplectic aphasia in silence, pain wind syndrome of head, spasmolytic throb with fear, the pestilence fan is vexed, kill small worm, the slow spleen of heat extraction, pregnant woman's head revolves and falls down to the ground, the frightened carbuncle of children's sky hangs, sore throat, dysphoria with smothery sensation.

Herba Artemisiae Scopariae: have another name called Herba Artemisiae Scopariae, because of dirt, horse is first, because of Herba Artemisiae Scopariae, and capillary wormwood, floss Artemisia, spire Herba Artemisiae Annuae, An Lvcao, Herba Artemisiae Sieversianae, Folium Pini Chinese mugwort, Tian Naili (Hakka) etc.Bitter in the mouth, suffering, cold nature.Return spleen, stomach, liver, gallbladder meridian.Eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.For the jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis etc.The pharmaceutical research Herba Artemisiae Scopariae has function of gallbladder promoting, and liver function protecting is analgesic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating; Herba Artemisiae Scopariae has significant hepatoprotective effect, and to first, hepatitis B, icterohepatitis, have significant curative effect.Function of gallbladder promoting is arranged, promote bile secretion, the effect that in increase bile, cholic acid and bilirubin are discharged. can increase the heart coronary flow, improve microcirculation, and blood pressure lowering is arranged, blood fat reducing, anticoagulation, diuresis is analgesic relievings asthma, and drives away ascarid and suppresses the effect of multiple pathogenic dermatophytes and antibacterial.

Radix Codonopsis: sweet in the mouth, property is flat.Return spleen, lung meridian.The spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, the cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry, grow stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not partially grown greasyly, inspires clear sun, gas in vibration, and without just dry fraud.Radix Codonopsis has the QI invigorating strengthening the spleen, the effect of nourishing blood to promote the production of body fluid, be mainly used in deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than the spleen reinforcing nourishing the stomach, adjusts regulating the function of middle-JIAO, has the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, facilitating digestion absorbs, and improves metabolism, promotes the absorption of intestinal to nutrient substance, Radix Codonopsis has certain antitumor assosting effect, can suppress the growth of gross tumor volume and weight, and reduces and shift.

Fructus Gardeniae: have another name called Yellow Fructus Gardeniae, Fructus Gardeniae, white toad, Mu Dan, bright, ancient wine vessel, stand, more peach, Fructus Gardeniae, yellow Ovum Gallus domesticus, yellow sprout are sub etc., are the fruits of Maguireothamnus speciosus Fructus Gardeniae.At present, the fruit of Fructus Gardeniae is Chinese medicine, belong to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, have the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, at tcm clinical practice, be usually used in treating the diseases such as icterohepatitis, bruise, hypertension, diabetes.Bitter in the mouth, cold in nature.GUIXIN, liver, lung, stomach, tri-jiao channel.The pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; The externally used detumescence pain relieving.Vexed for calentura, jaundice due to damp-heat, the puckery pain of stranguria, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles etc.; External treatment bruise pain.

Radix Et Rhizoma Rhei: have another name called general, Huang Liang, fire ginseng, skin as, another name for Sichuan Province Radix Et Rhizoma Rhei, Radixet Rhizoma Rhei, cow tongue Radix Et Rhizoma Rhei, bright and beautiful stricture of vagina, give birth to army, Radix Et Rhizoma Rhei.Hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.For the stagnant constipation of excess-heat, heat in blood is told nosebleed, the conjunctival congestion pharyngeal swelling, and carbuncle is treated skin ulcer, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, traumatic injury, hygropyretic dysentery, jaundice dark coloured urine, stranguria, edema; Externally treating burns and scalds.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For the conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.The hemostasis of charred Radix Et Rhizoma Rhei cooling blood and removing stasis.For heat in blood, stasis of blood hemorrhage is arranged.Modern medicine also prove Radix Et Rhizoma Rhei also have invigorate blood circulation, hemostasis, antibacterial, eliminate endotoxin, improve immunity of organisms, reduce the effects such as body temperature, analgesia.Radix Et Rhizoma Rhei contains anthraquinone, anthraquinone derivatives is stronger to staphylococcus, streptococcus antibacterial action; Tannin contained in Radix Et Rhizoma Rhei has good astriction to wound surface, can promote the wound face healing.

Semen Coicis: have another name called Semen Coicis, Semen Coicis, Semen Coicis, native Semen Maydis, Semen Coicis, a reality, heart of a lotus seed pearl, careless pearl pearl, jobstears, Semen Coicis, NLIUGU.The Chinese medicine of commonly using, be again generally, the food often eaten is also a kind of beauty food, normal food can keep human body skin gloss exquisiteness, eliminates acne, speckle passeris montani saturati, senile plaque, cyasma, butterfly spot, to desquamation, acne, chap, pachylosis etc. has good efficacy.Sweet in the mouth, light, cool in nature.Return spleen, stomach, lung meridian.Diuretic infiltration is wet, invigorating the spleen to arrest diarrhea, eliminating impediment, arrange dense, detoxicating and resolving stagnation of pathogens.For edema, beriberi, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, intestinal carbuncle; Wart, cancerous protuberance.1, on cardiovascular impact: suppress respiratory center, make particularly lung vasodilation of peripheral vessel.2, antitumor: especially hold wet pulmonary carcinoma under the arm with the digestive tract tumor of insufficiency of the spleen leading to overabundance of dampness and expectorant heat more suitable.In recent years, a large amount of scientific research and clinical practices prove, Semen Coicis or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% the suppression ratio of cancer.3, enhancing immunity and antiinflammatory action, Semen Coicis oil has facilitation to cellular immunization, humoral immunization.4, blood sugar lowering: can play blood vessel dilating and fall hypoglycemic effect, especially hypertension, hyperglycemia being had to special efficacy.5, suppress the contraction of skeletal muscle: Semen Coicis can suppress Skeletal Muscle Contraction, can reduce the contracture of muscle, shortens its fatigue curve; Can suppress the contraction of striped muscle.6, calmness, analgesia and refrigeration function: have calmness, analgesia and refrigeration function.The rheumatic arthralgia patient is had to good effect.7, fall blood calcium, slow down aging, improve the immunocompetence of body.8, edema; Foot gas; Dribbling urination; Damp-warm diseases; The leukorrhagia of having loose bowels; Rheumatic arthralgia; The contracture of muscle arteries and veins; Lung abscess; The intestinal carbuncle; Verruca plana.

Caulis Sargentodoxae: have another name called that Caulis seu Radix Schisandrae Henryi, Caulis Sargentodoxae, DAHUOXUE, large blood are logical, Folium Styracis Suberifoliae rattan, Spatholobus sinensis chum et T. Chen., Chrysanthemum are fickle in love, mountain Caulis Sargentodoxae, Schisandra glaucescens Diels., Herba pteridii latiusculi heart rattan, yellow stalk rattan, five spend seven, Rhizoma Homalomenae etc.Bitter in the mouth, property is flat.Enter stomach, large intestine channel.Heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, the dissipating blood stasis that relieves internal heat, wind dispelling insecticide.For abdominalgia with intestinal abscess, traumatic injury, dysmenorrhea, Fengshi Guanjie pain." Zhejiang traditional herbal medicine ": " property is flat, sour-puckery flavor." " Traditional Chinese Medicine in Sichuan will ": " is cool in nature, and bitter in the mouth is nontoxic.″。Enter liver.Large intestine two warps." " Bencao Tujing ": " attacks blood, controls clot." " simple and easy medical herbs ": " controls bones and muscles pain, chases after wind, strong waist knee joint, tonifying YANG thing." " Chinese medicinal herbal ": " the meridian dredging that dispels the wind, the diuresis parasite killing.Control acute appendicitis, rheumatic arthralgia, leprosy, gonorrhea: ascarid stomachache." " Hunan medicine will ": " is stimulated the menstrual flow and is enriched blood, bone and muscle strengthening, anthelmintic.Control traumatic injury, rheumatalgia, bruise, stranguria with blood, bones and muscles pain, furuncle, filaricide." " east, Fujian book on Chinese herbal medicine " " controls trusted subordinate's angor, dysentery." Guangzhou army " Chinese herbal medicine handbook commonly used: " controls podomere aches, numbness contracture, edema, blood deficiency giddy." " Shaanxi Chinese herbal medicine ": " anti-inflammation, dispersing swelling and dissipating binds, vital energy regualting and blood circulation-promoting, wind dispelling insecticide.Appendicitis curing, menoxenia, metrorrhagia, infantile malnutrition, ascarid, pinworm disease." " Zhiwu Mingshi Tukao ": Caulis Sargentodoxae, modern Lushan Mountain has it more.Overgrow, purple stem, a SANYE, just like a leaf thumb divides, or half of circle, or have angle and side is amorphous, smooth thick tough.Root long number chi, outer purple words spoken by an actor from offstage.Radial striations is arranged, excavate and expose to the sun it, purple liquid Jin Run.Infusing drugs in wine one night, bright red such as blood.

Fructus Mume: have another name called dark plum, yellow young, close Chinese prunus mume (sieb.) sieb.et zucc., a dry branch prunus mume (sieb.) sieb.et zucc., Fructus Mume, smoked prunus mume (sieb.) sieb.et zucc., Fructus Citri tangerinae plum pulp, prunus mume (sieb.) sieb.et zucc., spring prunus mume (sieb.) sieb.et zucc. etc.Sour in the mouth, puckery, property is flat.Return liver, spleen, lung, large intestine channel.Astringe the lung, astringing intestine to stop diarrhea, promote the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic diarrhea chronic dysentery, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache; Chronic malaria; Have blood in stool; Hematuria; Metrorrhagia; Ancylostomiasis etc.

Borneolum Syntheticum: having another name called sheet brain, Fructus Citri tangerinae sheet, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., is that resin and the volatile oil processed goods of Spore density Borneolum Syntheticum extracts the crystallization obtained, and is near pure dextro Borneolum Syntheticum.Also useful chemical method is synthetic.Acrid in the mouth, hardship, cold nature.GUIXIN, spleen, lung meridian.The refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.For calentura coma, convulsions, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, obstruction of qi in the chest and cardialgia, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.

Herba Lysimachiae: have another name called Lysimachia christinae Hance, Herba pteridis vittatae, Hydrocotyle vulgaris L., Herba cassiae torae, Herba Lysimachiae, Lysimachia christinae Hance, a string money, Herba Dichodrae, money false aloe, rattan rattan Herba Houttuyniae, large Herba Glechomae, LUBIANHUANG etc.Sweet in the mouth, one-tenth, cold nature.Return liver, gallbladder, kidney, urinary bladder channel.The wet jaundice eliminating of thorn, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, gallbladder-distention hypochondriac pain, stranguria caused by urinary stone, pyretic stranguria, difficulty and pain in micturition, carbuncle furuncle, snake bite and insect sting.Modern study, these product mainly contain phenolic constituent and sterol, flavonoid, aminoacid, tannin, volatile oil, choline, potassium salt etc.Also have calculus, antibacterial, antiinflammatory action, all have inhibitory action to humoral immunization, cellular immunization.

Grifola umbellata: Aphyllophorales Polyporaceae Ramalina medicinal fungi.Have another name called Rhizoma Anemones flaccidae peach, pig Poria, pig Ganoderma, Jia pig arrow, pig bag, maple Siberian cocklebur, POLYPORUS, Zhu Ling, wild boar excrement, wild boar food etc.Sweet in the mouth, light, property is flat, returns kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen, detumescence.Control dysuria, edema, have loose bowels, stranguria with turbid discharge, be with inferior.Polyporus contains polyporusum bellatus, and polyporusum bellatus can significantly strengthen mouse T cell to the breeder reaction to LPS of the breeder reaction of ConA and B cell.Polyporusum bellatus has obvious mitogenesis effect to the full splenocyte of mice.Under 12.5mg/ (kg days) dosage, polyporusum bellatus can obviously strengthen the specific antibody secretory cell number of mice to SRBC; Can obviously strengthen mice to special-shaped splenocyte delayed hypersensitivity and promote special-shaped spleen cell activation cytotoxic T cell (CTL) killing and wounding target cell.CTL is the important effect cell that immunity of organism monitors, in tumour immunity, has pivotal role.The antitumor action of polyporus extract: polyporus extract (being mainly polyporusum bellatus) has more significant inhibitory action to mice transplanted tumor S-180.Inhibitory rate 50-70%, the heavy suppression ratio of tumor reaches more than 30%.In the tumor-bearing mice of extract for treating, approximately there is the 6-7% tumor to disappear fully.Mice to tumor disappears fully, inoculate tumor cell at 1-6 after the month, the tumor of all not growing, extract is through administrations such as lumbar injection, intravenous injection and gavages, under doses, all can suppress the growth of tumor, but the effect of gavage is poor than lumbar injection and intravenous injection, dosage is also large.The prevention administration plays tumor-inhibiting action to S-180.In alone chemotherapeutic, do not show under the dosage of antitumous effect, add with appropriate polyporus extract and have remarkable antitumor action.To tumor-bearing mice spleen antibody produced cell showed increased, show significant enhancing antibody formation effect is arranged, can also significantly improve tumor-bearing mice peritoneal macrophage phagocytic activity.This product can improve the content of cAMP in the S-180 ascites cells, and at the high experimental group of cancer cell multiplication suppression ratio, in cancerous cell, cAMP content enhancing rate is also high, and in general cancerous cell, cAMP content is lower than normal cell, and it is lower that canceration more worsens cAMP content.CAMP can make tumor cell transform to normal cell.Polyporus ketone A-G, 7 kinds of compounds have cytotoxicity to the L1210 cell, and the inhibitory action of dose dependent is arranged.Inhibitory action to experimental tumor of bladder: female rats awards carcinogen BBN[N-butyl-N-(4-hydroxyl butyl) nitrosamine] solution 0.25ml (90mg) gavage, 2 times weekly, in totally 12 weeks, every accumulated dose BBN is 2.16g, raises at the same time with Polyporus dry powder 90g/kg and feeds.After 30 weeks, put to death.Result shows, bladder is always sent out ratio of outflow and is down to 61.1% by 100% of pathology matched group, reduced 38.9%, every Mus number of tumors and tumor diameter are significantly lower than the pathology matched group, send out the cancer rate and be down to 11.1% by 77.8% of pathology matched group, reduced 66.7% and shown that Polyporus is to the more significant inhibitory action of having of BBN bladder tumor, and without obvious toxic-side effects.

Fructus Galangae: have another name called Semen Phaseoli, FRUCTUS GALANGAE, red button etc.Acrid in the mouth, warm in nature.Return spleen, lung meridian.Warming middle-JIAO dampness; Cold expelling dampness, be amusing and help digestion.For coldness and pain in the epigastrium, food stagnation distension, vomiting is had loose bowels, drinking too much.Pharmacological action: 1. the seed decoct has excitation to the guinea pig in vitro intestinal tube.1-acetoxychavicol acetate 5,10g/kg lumbar injection, the gastric ulcer that rat ligation pylorus is caused has inhibitory action.1-acetoxychavicol acetate and 1-acetoxyeugenol acetate have the effect of obvious anti-ShayShi rat gastric ulcer, and when difference lumbar injection 2-Smg/kg and 5-10mg/kg, suppression ratio is 20-77% and 36-100%.2. antifungal and cytotoxic effect: the Galahal A (1) that these product contain, Galanal B (2), Galanolactone (3), (E)-8 (17), 12-Labddiene-15,16-dial (4) and (E)-8B (17)-Epoxylabd-12-ene-15,16-dial (5) has antifungal and cytotoxic effect.3. active anticancer: from getting multiple compounds the methanolic extract of fruit, to again wherein 1-acetoxy-chavicol ethyl ester and 1-acetoxyl group Eugenol acetate, give the dosage of mice by intraperitoneal injection 10mg/kg, continuous 5 days, find that there is very strong active anticancer.The latter's toxicity is lower than the former.With other synthetic ingredient, compare, the 1-acetoxyl group is very important to active anticancer, estimates that its mechanism of action is relevant with nucleophillic attack.

Rhizoma Curcumae Longae: have another name called Dioscorea zingiberensis, hair Rhizoma Curcumae Longae, tripod perfume, Huang Siyu etc.Acrid in the mouth, hardship, warm in nature.Return spleen, Liver Channel.The removing blood stasis circulation of qi promoting, relieving pain of dysmenorrhea.For the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, dysmenorrhea amenorrhea ， mass in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.Modern pharmacological research, the Main Function of Rhizoma Curcumae Longae is: 1. effect for reducing blood fat; 2. antitumor action; 3. antiinflammatory action; 4. resisting pathogenic microbes effect; 5. on the impact of cardiovascular system; 6. choleretic effect; 7. to the effect of termination of pregnancy; 8. antioxidation; 9. photo effect effect; 10. other effect: curcumin can suppress the biosynthesis of PGS.Rhizoma Curcumae Longae also can kill fly.The chloroform of Rhizoma Curcumae Longae and ether extract are external has inhibitory action to Trichophyton and microsporon gypseum.Turmeronol A and B can suppress the Semen sojae atricolor lipoxygenase, and its IC50 is respectively 16 and 19 μ mol/L.These two kinds of compounds can prevent linoleic autoxidation when-200ppm concentration.

Rhizoma Acori Graminei: have another name called prosperous, Chinese onion when Rhizoma Acori Graminei, prosperous sun, prosperous grass, Yao, Yao's fragrant-flowered garlic, haze tallow, spring snow, see disappear, water Rhizoma Acori Graminei, bitter Rhizoma Acori Graminei, powder Chang, Rhizoma Acori Graminei, sword-like leave, Rhizoma Acori Graminei, mountain Rhizoma Acori Graminei, small stream Chang, stone Scolopendra, wild leek, Herba Kyllingae, Rhizoma et radix valerianae etc.Acrid in the mouth, hardship, warm in nature.GUIXIN, stomach warp.The eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae, removing dampness appetizing.For coma epilepsy, forgetful insomnia, Hiccough and deaf, the gastral cavity painful abdominal mass is not hungry, mouthful dysentery of keeping silent; Regulate the flow of vital energy, invigorate blood circulation, loose wind, dry.Control epilepsy, syncope due to accumulation of phlegm, the calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, the diseases such as traumatic injury.

Fructus Lycii: have another name called Fructus Lycii, Fructus Lycii red real, Radix Betae is sub, FRUCTUS LYCII BARBARI, Canis familiaris L. milk, dark purple green pepper, Chinese holly hoof etc.Sweet in the mouth, property are put down.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.Liver and kidney tonifying is arranged, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii can promote liver cell regeneration, the effect of enhancing non-specific immunity function.

Rhizoma Belamcandae: have another name called that dry, black Wooden-fan of black fan, Wu Pu, yellow far away, black Sha, night, crow blow, careless Rhizoma Zingiberis Recens, ghost fan, the phoenix wing etc.Bitter in the mouth, cold in nature.Return lung meridian.Heat-clearing and toxic substances removing, expectorant, sore-throat relieving.For pyretic toxicity phlegm-fire Tai knot, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.

Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.For heat, enter nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, abdominal mass abdominal mass stomachache, injury from falling down, carbuncle skin infection.Giving birth to Radix Paeoniae Rubra wins with clearing away heat and cooling blood power.Multiplex fever of the body in the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases is hemorrhage, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus.Wine Radix Paeoniae Rubra: with promoting blood circulation to remove blood stasis power victory, a little less than clearing away heat and cooling blood effect.Multiplex in amenorrhea or dysmenorrhea, traumatic injury.The Radix Paeoniae Rubra minute excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function and Cortex Moutan are close, with the Cortex Moutan mutual reinforcement between, are use therefore normal.But the effect of Cortex Moutan clearing away heat and cooling blood is better, minute excess-heat that can purify the blood, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only, for the blood system excess-heat, be good at promoting blood circulation to remove blood stasis.

Radix Trichosanthis: sweet in the mouth, micro-hardship, cold nature.Attach to the lung and stomach meridians.Clearing away heat-fire, promoting the production of body fluid to quench thirst, detumescence and apocenosis.For the calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, the cards such as sore swollen toxin, Radix Trichosanthis has and suppresses and the stimulation dual function immune system, cancerous cell is had to efficient direct killing effect, " book on Chinese herbal medicine converge with speech ": Radix Trichosanthis, move back the five internal organs hot and suffocating, as heart-fire, contain and dry tongue and mouth, lung-fire is contained and the pharyngeal swelling sore throat, and spleen-fire is contained and the dispute tooth is swollen, and phlegm-fire is contained and cough is not peaceful.If the swollen migratory arthralgia caused by wind of the side of body of liver-fire, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle burst and burst, and pyretic toxicity is loose, or five types of jaundice yellow skin and eye, and if if little water drenches puckeryly, be due to all burning hot pent-up, only this agent energy relieving stagnation, fall phlegm-fire, and can control it.Its property is sweet cold again, kindly can control yearningly, from tonic, controls empty yearningly, from the medicine of a cold nature, controls fire thirsty, from the gas medicine, controls strongly fragrant yearningly, controls excessive thirst from the blood medicine, is to control thirsty key medicine also.

The ratio of weight and number of the raw medicinal material in described Chinese medicine composition can be preferably: Herba Sarcandrae 20～35 weight portions, Zaocys 8～15 weight portions, Herba Scutellariae Barbatae 12～15 weight portions, Herba Lobeliae Chinensis 15～30 weight portions, Herba Hedyotidis Diffusae 20～30 weight portions, Herba Taraxaci 30～50 weight portions, Herba Violae 25～40 weight portions, Herba Patriniae 18～30 weight portions, Flos Lonicerae 35～50 weight portions, Fructus Forsythiae 10～20 weight portions, Radix Glycyrrhizae 20～35 weight portions, Herba Lophatheri 20～30 weight portions, Herba Artemisiae Scopariae 15～25 weight portions, Radix Codonopsis 16～34 weight portions, Fructus Gardeniae 15～20 weight portions, Radix Et Rhizoma Rhei 10～15 weight portions, Semen Coicis 20～40 weight portions, Caulis Sargentodoxae 15～30 weight portions, Fructus Mume 20～35 weight portions, Borneolum Syntheticum 25～30 weight portions, Herba Lysimachiae 15～25 weight portions, Polyporus 20～35 weight portions, Fructus Galangae 20～45 weight portions, Rhizoma Curcumae Longae 15～20 weight portions, Rhizoma Acori Graminei 10～15 weight portions, Fructus Lycii 25～35 weight portions, Rhizoma Belamcandae 18～25 weight portions, Radix Paeoniae Rubra 15～25 weight portions and Radix Trichosanthis 30～50 weight portions.

Poria: have another name called Fu Tu, Poria, Fu Ling, Fu Ling, volt Tu, loose fat, deep red morning and lie prostrate tire, Poria, Fu rabbit, loose potato, Masson Pine potato, Song Ling etc.Sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Modern medicine study: Poria energy enhancing human body immunity function, pachyman have obvious antitumor and protect the liver dirty effect.

Radix Ginseng: SHANSHEN, Park Ginseng, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), wooden club, Rhizoma Panacis Japonici, SHENCAO, Sphallerocarpus gracilis, Herba Wedeliae Wallichii, Herba Stellariae Saxatilis, hundred chi pestles, extra large fat, the beautiful door screen of golden well, Radix Ginseng etc.Sweet in the mouth, micro-hardship, slightly warm in nature.Return spleen, lung, the heart, kidney channel.Strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, and invigorating the spleen to benefit the lung, promote the production of body fluid and nourish blood, the Fructus Alpiniae Oxyphyllae of calming the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, prolonged illness is empty wins, the palpitation with fear insomnia, sexual impotence official is cold.Cure mainly: impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency multiple, the disease of all qi-blood-body fluid deficiencies.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, the cards such as frequent fetal movement; The Rhizoma Atractylodis Macrocephalae have adjust gastrointestinal motility function, antiulcer, protect the liver, the effects such as enhancing human body immunity function, anti-stress, enhancing hemopoietic function; Its dampness diuretic effect is relevant with diuresis; And antiabortive effect is relevant with the effect of inhibition uterine contraction.The Rhizoma Atractylodis Macrocephalae also has the effects such as antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor, the Rhizoma Atractylodis Macrocephalae can improve the immunologic function of body, increase quantity of leucocyte, the special active immunity of new-added item cancer cell antigen antibody, by reducing the rate of increase of oncocyte, lower the aggressive of tumor tissue, improve body antitumor respond and to the cytotoxic effect of oncocyte, thereby suppress tumor.The Rhizoma Atractylodis Macrocephalae has cytotoxic effect to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection, to the murine sarcoma people, also has remarkable inhibitory action.

When containing tablet, its preparation method comprises the following steps when the dosage form of described Chinese medicine composition:

When the dosage form of described Chinese medicine composition was syrup, its preparation method comprised the following steps:

When the dosage form of described Chinese medicine composition is capsule, its preparation method comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1: prepared by the present invention contains tablet

Herba Sarcandrae 28g, Zaocys 12g, Herba Scutellariae Barbatae 15g, Herba Lobeliae Chinensis 15g, Herba Hedyotidis Diffusae 22g, Herba Taraxaci 35g, Herba Violae 32g, Herba Patriniae 23g, Flos Lonicerae 40g, Fructus Forsythiae 18g, Radix Glycyrrhizae 25g, Herba Lophatheri 20g, Herba Artemisiae Scopariae 15g, Radix Codonopsis 26g, Fructus Gardeniae 15g, Radix Et Rhizoma Rhei 15g, Semen Coicis 25g, Caulis Sargentodoxae 20g, Fructus Mume 30g, Borneolum Syntheticum 30g, Herba Lysimachiae 20g, Polyporus 30g, Fructus Galangae 35g, Rhizoma Curcumae Longae 20g, Rhizoma Acori Graminei 10g, Fructus Lycii 35g, Rhizoma Belamcandae 25g, Radix Paeoniae Rubra 20g and Radix Trichosanthis 35g.

Its preparation method comprises the following steps:

The first step, by Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Acori Graminei, with Radix Trichosanthis, mix in described ratio, use the dissolve with ethanol with respect to the determining alcohol 95% of 5 times of the mixture quality obtained, reflux was extracted after 3 hours, filter, filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 90% of 3 times of the mixture quality obtained again, reflux was extracted after 2 hours again, filter, merge filtrate twice, decompression recycling ethanol to be concentrated into liquor strength be 1.2g crude drug/mL, above-mentioned filtrate is the macroporous adsorptive resins of 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, drying also is ground into powder,

Second step, Rhizoma Belamcandae, Radix Paeoniae Rubra, Herba Violae, Herba Patriniae, Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Herba Lysimachiae and Polyporus are mixed in described ratio, the alcohol heating reflux added with respect to the determining alcohol 90% of 4 times of the mixture quality obtained extracts 2 times, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity was evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density was 1.20～1.23 mastic, and the mastic after concentrated is dried to powder with spray dryer;

The 3rd step, mix the surplus stock medical material in described ratio, add the water dissolution of 4 times with respect to the mixture quality obtained, and heating decocted 3 hours, filters; Filtering residue is used to the water dissolution of 3 times with respect to the mixture quality of acquisition again, and heating decocted 2 hours again, filtered, and merged filtrate, and concentrating under reduced pressure is removed moisture, and drying also is ground into powder;

The 4th step, three kinds of powder that obtain are previously mixed, further add with respect to the carboxymethyl starch sodium of 0.08 times of the mixture quality obtained, the microcrystalline Cellulose of 0.08 times, mix, granulate, after drying, granulate, add the magnesium stearate with respect to 0.03 times of the mixture quality obtained, then with decompressor by the granule compacting in flakes, obtain the tablet that contains of the present embodiment.

Capsule prepared by embodiment 2 the present invention

Herba Sarcandrae 25g, Zaocys 10g, Herba Scutellariae Barbatae 13g, Herba Lobeliae Chinensis 18g, Herba Hedyotidis Diffusae 23g, Herba Taraxaci 40g, Herba Violae 35g, Herba Patriniae 20g, Flos Lonicerae 35g, Fructus Forsythiae 15g, Radix Glycyrrhizae 30g, Herba Lophatheri 22g, Herba Artemisiae Scopariae 18g, Radix Codonopsis 28g, Fructus Gardeniae 16g, Radix Et Rhizoma Rhei 12g, Semen Coicis 20g, Caulis Sargentodoxae 16g, Fructus Mume 25g, Borneolum Syntheticum 28g, Herba Lysimachiae 22g, Polyporus 32g, Fructus Galangae 30g, Rhizoma Curcumae Longae 25g, Rhizoma Acori Graminei 11g, Fructus Lycii 30g, Rhizoma Belamcandae 22g, Radix Paeoniae Rubra 23g, Radix Trichosanthis 32g, Poria 18g, Radix Ginseng 30g and Rhizoma Atractylodis Macrocephalae 25g.

Its preparation method comprises the following steps:

The first step, be mixed in proportion described raw medicinal material, puts into marmite and fried 35 minutes, is ground into smalls with pulverizer, is screened into 120 purpose powder;

Second step, the determining alcohol that adds 4 times of the powder qualities that obtain with respect to the first step is 80% ethanol, reflux 3 hours, extract merge extractive liquid, 2 times, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to without the alcohol flavor, filters the medicinal residues that obtain and add the distilled water with respect to 6 times of filtering residue quality again, the each decoction 2 hours, decoct 2 times, filter respectively, merging filtrate obtains water extraction liquid, water extraction liquid concentrating under reduced pressure, with the concentrated solution of the alcohol extract obtained previously, mix, further concentrating under reduced pressure, remove desolventizing, drying, obtain and get dry extract;

The 3rd step, be broken into 300 purpose powder by described dried cream powder, in the powder obtained, adds excipient, disintegrating agent mixing, dry, pulverizing, adds fluidizer, in finally incapsulating, obtains capsule;

Wherein, excipient is starch and/or dextrin, and its weight content in capsule is 20%;

Disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in capsule is 10%;

Fluidizer is magnesium stearate, and its weight content in capsule is 2%.

Embodiment 3 syrup of the present invention

Herba Sarcandrae 30g, Zaocys 14g, Herba Scutellariae Barbatae 12g, Herba Lobeliae Chinensis 16g, Herba Hedyotidis Diffusae 25g, Herba Taraxaci 30g, Herba Violae 30g, Herba Patriniae 23g, Flos Lonicerae 45g, Fructus Forsythiae 20g, Radix Glycyrrhizae 22g, Herba Lophatheri 24g, Herba Artemisiae Scopariae 15g, Radix Codonopsis 30g, Fructus Gardeniae 20g, Radix Et Rhizoma Rhei 10g, Semen Coicis 30g, Caulis Sargentodoxae 25g, Fructus Mume 30g, Borneolum Syntheticum 29g, Herba Lysimachiae 25g, Polyporus 33g, Fructus Galangae 40g, Rhizoma Curcumae Longae 26g, Rhizoma Acori Graminei 12g, Fructus Lycii gives 33g, Rhizoma Belamcandae 25g, Radix Paeoniae Rubra 25g, Radix Trichosanthis 40g.

Its preparation method comprises the following steps:

The first step, by Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Acori Graminei, with Radix Trichosanthis, mix in described ratio, use the dissolve with ethanol with respect to the determining alcohol 90% of 4 times of the mixture quality obtained, reflux was extracted after 3 hours, filter, filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 95% of 2 times of the mixture quality obtained again, reflux was extracted after 2 hours again, filter, merge filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.0g crude drug/mL, above-mentioned filtrate is the macroporous adsorptive resins of 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, drying also is ground into powder,

Second step, Rhizoma Belamcandae, Radix Paeoniae Rubra, Herba Violae, Herba Patriniae, Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Herba Lysimachiae and Polyporus are mixed in described ratio, the alcohol heating reflux added with respect to the determining alcohol 95% of 4 times of the mixture quality obtained extracts 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity was evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density was 1.20～1.23 mastic, and the mastic after concentrated is dried to powder with spray dryer;

The 3rd step, the surplus stock medical material is mixed in described ratio, add the water dissolution of 3 times with respect to the mixture quality obtained, heating decocted 2 hours, filtered, filtering residue is used to the water dissolution of 2 times with respect to the mixture quality obtained again, heating decocted 2 hours again, filtered, and merged filtrate, concentrating under reduced pressure is removed moisture, and drying also is ground into powder;

The 4th step, mix three kinds of powder that obtain above, adds the water dissolution with respect to 2 times of mixture qualities, with 40% sodium hydroxide solution, regulate pH value to 7.0, stir evenly, cold preservation is 48 hours under 5 ℃ of conditions, filter, filtrate adds the sucrose with respect to 0.3 times of the mixture quality obtained, and stirs and dissolves, regulate pH value to 7.0, add water appropriate, stir, static 16 hours, filter fill, sterilizing, obtain syrup, the crude drug concentration in syrup is 1.2g/mL.

1. external used medicine toxicity test

Acute oral toxicity test: these product are by Ministry of Public Health " cosmetics health standard " (version in 2002) " test method(s) of once limiting the quantity of in acute oral toxicity test ", one time per os gives the ICR mice, body weight 18g～22g, 20, the tablet that contains that the embodiment of the present invention 1 is obtained dissolves with distilled water, obtain gavage dosage 5000mg/kg body weight, gavage amount 20ml/kg, observed 15 days, experimental animal is not found poisoning manifestations, nothing death, after putting to death, dissect obviously not extremely, judge that these product are to the nontoxic level in the true border of chmice acute Oral toxicity.

The acute dermal toxicity test: these product are according to Ministry of Public Health " cosmetics health standard " (2002) second portion " acute dermal toxicity test " test method(s) of once limiting the quantity of, 20 of SD rats, male and female half and half, body weight 90g～180g, the tablet that contains that the embodiment of the present invention 1 obtains is pulverized, add 400g rubber, 400g Colophonium to make coating, one time percutaneous is smeared 5000mg/kg body weight dosage, observed 15 days, do not find obvious poisoning symptom, nothing death, animal gross anatomy no abnormality seen, judge that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.

Acute skin irritation test: these product are according to 6.3 joints in Ministry of Public Health " cosmetics health standard " (2002) second portions " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg, method according to above-mentioned " acute dermal toxicity test ", prepare coating, then getting 0.5g directly spreads upon on the skin of animal left side (opposite side in contrast), adopt blocking test, 4 hours application time, after off-test, use the residual tested material of warm water washing, 1h after removing tested material, 24h, 48h and 72h observe respectively the dermoreaction of the tested district of animal and check plot, the top average is " 0 ", judge that these product are to the animal skin nonirritant.

2. endo-medicine long term toxicity test:

By the embodiment of the present invention 1 contain tablet to mice by 7.81,18.34 and the 40.11g crude drug/12 weeks of kg continuous use (1.0ml/100g body weight, every day 2 times) and after 4 weeks of drug withdrawal, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, the internal organs naked eyes do not find that difference changes and the histological examination result shows, after 12 weeks of medication and 4 weeks of drug withdrawal, each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to the rat long-term prescription, after drug withdrawal, also there is no the difference reaction, application safety.

3. tumor-inhibiting action test

Subjects: 100 of ICR mices, body weight 18-22g, male.

Test inoculation content: S ₁₈₀Solid tumor.

Get the ICR mice, in the subcutaneous conventional inoculation S of right axil ₁₈₀Cancerous cell suspension 0.2ml (approximately 5 * 10 ⁶Individual cell/ml), be divided at random 4 groups next day.Treatment group is divided into three groups, is respectively high dose group, middle dosage group and low dose group, adopts the tablet that contains of the embodiment of the present invention 1, and after pulverizing, distilled water dissolves, and every day is gastric infusion 1.2ml, 0.8ml and 0.4ml respectively, continuous 10 days; Matched group is divided into two groups, is respectively normal saline group and CTX group, and normal saline group stomach every day is raised the 0.4ml normal saline, continuous 10 days; CTX group administration cyclophosphamide, gastric infusion after administration every day 0.2g, distilled water dissolve, continuous 10 days; 4 groups are and put to death animal next day after drug withdrawal, and the stripping tumor is weighed, and calculates tumour inhibiting rate, and result shows, the present invention is to S ₁₈₀Growth has inhibitory action, and its tumour inhibiting rate increases and increases progressively with dosage, with matched group, has compared significant difference P<0.05.To S ₁₈₀Inhibitory action and tumor killing effect in Table 1.

Table 1: to S ₁₈₀Inhibitory action and tumor killing effect

Group	Average tumor heavy (g)	The mice average weight changes (g)	Tumour inhibiting rate (%)
				High dose group	1.83±0.64	+4.12	56.23
Middle dosage group	1.96±0.32	+4.59	51.87
				Low dose group	2.18±0.57	+4.92	48.32
The CTX group	1.64±0.28	-1.62	61.36
				The normal saline group	3.22±0.96	+4.97	0

As can be known by table 1: adopt the treatment group of Chinese medicine preparation of the present invention, with the normal saline group relatively, can suppress the tumor bulk-growth, and tumour inhibiting rate increases progressively with the increase of dosage, significant difference P<0.05 is arranged, (n=10, X ± SD); Adopt the treatment group of Chinese medicine preparation of the present invention, with the CTX group relatively, the body weight of the mice for the treatment of group has increase, and the Mouse Weight of CTX group alleviates, both significant difference P<0.05 of having compared, (n=10, X ± SD).

By the fluid cell instrument, measure in addition, the result demonstration, Chinese medicine preparation of the present invention has stoped tumor cell by S → G ₂Process, also affected G simultaneously ₁The carrying out of → S, make S and G ₁The cell of phase obviously increases, G ₂Relatively low with the cell of M phase, disturbed the propagation activity of tumor cell, reach antineoplastic action.

4. clinical experiment

4.1 case grouping and therapeutic scheme

By cancer of pancreas case 252 examples, male 144 examples wherein, female's 108 examples, the age, from 21 years old～72 years old, is adopted the random table method, patient is divided into to Chinese drug-treated group, chemotherapy group and Chinese medicine at random and adds chemotherapy group;

Chinese drug-treated group 84 people, male 48 people, female 36 people, the oral embodiment of the present invention 1 contain tablet, every day 3 times, each 2, every surrounding is one-period.

Chemotherapy group 84 people, male 47 people, female 37 people, chemotherapeutics is selected cisplatin (CDDP) 30mg/M ²D1-3, gemzar 1000mg/M ²D1,8,15, fluorouracil (5-Fu) 500mg/M ²D1-5, select 2 kinds or 3 kinds of drug combinations wherein during chemotherapy, intravenously administrable, and 28 days is one-period.

Chinese medicine adds chemotherapy group 84 people, male 49 people, and female 35 people, the capsule of the oral embodiment of the present invention 2, every day 3 times, each 2, every surrounding is one-period; While intravenously administrable chemotherapeutics (the same chemotherapy group of method).

Before all patient's radiotherapies, all through pathology, confirm, and all there is x-ray to take the photograph sheet, CT scan or nuclear magnetic resonance check for clinical TNM by stages, before before chemotherapy, all doing chemotherapy by clinical criteria, check that confirmation is without the chemicotherapy contraindication, all patients are all without shifting cancer of pancreas (M0).

International cancer of pancreas TNM by stages with clinical stages:

International cancer of pancreas TNM is (UICC, 1987) by stages, and T refers to the primary tumo(u)r situation, and N refers to the lymph metastasis situation, and M refers to the metastasis situation.

(1) primary tumo(u)r (T) is by stages:

Tx: can not judge; T0: without the primary tumo(u)r evidence; T1: former swelling do not exceed pancreas; T1a: tumor≤2cm; T1b: tumor>2cm; T2: tumor invading duodenum, biliary tract or pancreas surrounding tissue; T3: tumor invading stomach, spleen, colon, trunk.

(2) zonule lymph node (N) is by stages:

Nx: can not judge; N0: regional lymph nodes is without transfer; N1: regional lymph node metastasis is arranged;

(3) metastasis (M) is by stages:

Mx: can not judge; M0: without metastasis; M1: metastasis is arranged.

Clinical stages

The I phase: T1 N0 M0; T1 NX M0; TX N0 M0; TX NX M0.

The II phase: T2 N0 M0; T2 NX M0; T3 N0 M0; T3 NX M0.

The III phase: any T, N1, M0:.

The IV phase: any T, any N, M1.

4.2 evaluation criteria: according to WHO treatment malignant tumor evaluation criteria evaluation curative effect, minute alleviation (CR) fully: all visible pathological changes disappeared for 4 weeks fully at least; Partial rcsponse (PR): tumor size is estimated to dwindle >=50% at least 4 week; Unchanged (NC): without at least 4 weeks of significant change, comprise that pathological changes is stable, tumor size is estimated to enlarge less than 25%, dwindles less than 50%; Pathological changes expansion (PD): new focus occurs or original pathological changes is estimated to enlarge>25%; 4 ranking pancreas section's primary tumors and Metastatic Lymph Nodes gross tumor volume change.

4.3 statistical method:

With statistical package SPSS1010 Wileoxon, meet rank test, paired t-test and independent sample t check.

4.4 result of the test

According to above-mentioned WHO evaluation criteria, drug treatment, after 4 months, carries out the short term effect statistical effect respectively, the results are shown in Table 2.

Table 2: each group short term effect tracking table record

Group	CR	PR	NC	PD	Effective percentage (%)
						Chinese drug-treated group	11	43	22	8	64.3
Chemotherapy group	6	27	35	16	39.3
						Chinese medicine adds chemotherapy group	15	46	18	5	72.6

As can be known by table 2, Chinese medicine preparation of the present invention (general 3-6 month) in a short time obviously dwindles lump, effectively control the cancerous cell diffusion, increase clinical cure patient's ratio, and sum up and regular x-ray, CT or ultrasound diagnosis etc. by clinical observation, patient's patient's condition inquiry every day, determine that Chinese medicine preparation of the present invention can be in a short time (general 3-6 month) and alleviate fast or eliminate epigastrium distension discomfort or distending pain, jaundice, tired, loss of appetite, become thin, the symptoms such as diarrhoea or constipation, alleviate the patient suffering, stablize the state of an illness; Can also increase simultaneously the therapeutic effect of chemotherapy, and reduce the side effect of chemotherapy.

All patients are carried out to the long-term follow record, and add up respectively survival number and survival rate when 1 year, 2 years, 3 years and 5 years, concrete data are in Table 3.

Table 3: each group long-term survival rate is followed the tracks of survival number and survival rate

Group	1 year	2 years	3 years	5 years
					Chinese drug-treated group	38(45.2)	31(36.9)	22(26.2)	15(17.9)
Chemotherapy group	19(22.6)	8(9.5)	1(1.2)	0(0)

Chinese medicine adds chemotherapy group

43(51.2)

35(41.7)

24(28.6)

18(21.4)

As can be known by table 3, Chinese medicine preparation of the present invention can obviously improve the life span of Pancreas cancer patients, improves clinical cure patient's ratio, increases simultaneously the therapeutic effect of chemotherapy and the side effect of minimizing chemotherapy; Chinese drug-treated group and Chinese medicine add chemotherapy group, compare with chemotherapy group, have significant difference.

Model case:

Zhang, man, 68 years old.Patient's body constitution is strong, and element is without chronic disease.Upper left abdomen dull pain between in January, 2004, the time while doing only, extremely do not mind.The pain increased at the beginning of 3 months, sometimes is impatient at, and begins to hospital admission.Mid-March, report: " 1. gallbladder increased, cholecystitis to hospital's CT examination.2. the uncinate process of pancreas occupy-place may." the tentative diagnosis suggestion is cancer of pancreas.The suggestion excision, the patient is high seriously ill and refuse with year, introduces and determines to adopt treatment by Chinese herbs through the friend.Late March is to the here first visit, and patient's cardinal symptom at that time is malaise and upper left abdomen pain, and its characteristics are that swollen sense is more than pain.Swollenly very feel bad when anxious, uneasy in either sitting or lying, and have mechanism of qi on ambition, to push up on umbilicus.The pain paroxysm, severe pain can cause groan sometimes.Stomach receive still can, self-regulated convenient to both.Without heating and gallbladder, the intestines and stomach symptom.Large pulse is not smooth, one expiration and inspiration four to.Body of the tongue is light red, white and thin fur and greasy, tongue light yellow complexion.Arteries and veins disease is deficiency of vital energy dysfunction of the spleen accordingly, and turbid being detained of expectorant hands over and coagulate with QI and blood, becomes abdominal mass long-pending, holds for a long time poison to become evil disease.The square tablet that contains by the embodiment of the present invention 1, every day three times, each 3, after three first quarter moons of taking medicine, the patient is with transference cure, and slight illness is alleviated and drug withdrawal voluntarily.To August next year, drug withdrawal is ten April, because of upper abdomen severe pain, are in hospital again.Be diagnosed as the gallbladder inflammatory swelling, the excision of performing a surgical operation.The rear inspection pancreas that first gives of cutting open the belly, be shown in the cancerous protuberance of atrophy focus arranged.Confirm that the patient is strictly cancer of pancreas original suffering from, and also confirms that treatment by Chinese herbs has made recovery from illness.

All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away from, to any simple modification, equivalent variations and remodeling that above embodiment does, still belong to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

Claims

1. Chinese medicine composition for the treatment of cancer of pancreas, it is characterized in that: the ratio of weight and number of the raw medicinal material in described Chinese medicine composition is: Herba Sarcandrae 20～35 weight portions, Zaocys 8～15 weight portions, Herba Scutellariae Barbatae 12～15 weight portions, Herba Lobeliae Chinensis 15～30 weight portions, Herba Hedyotidis Diffusae 20～30 weight portions, Herba Taraxaci 30～50 weight portions, Herba Violae 25～40 weight portions, Herba Patriniae 18～30 weight portions, Flos Lonicerae 35～50 weight portions, Fructus Forsythiae 10～20 weight portions, Radix Glycyrrhizae 20～35 weight portions, Herba Lophatheri 20～30 weight portions, Herba Artemisiae Scopariae 15～25 weight portions, Radix Codonopsis 16～34 weight portions, Fructus Gardeniae 15～20 weight portions, Radix Et Rhizoma Rhei 10～15 weight portions, Semen Coicis 20～40 weight portions, Caulis Sargentodoxae 15～30 weight portions, Fructus Mume 20～35 weight portions, Borneolum Syntheticum 25～30 weight portions, Herba Lysimachiae 15～25 weight portions, Polyporus 20～35 weight portions, Fructus Galangae 20～45 weight portions, Rhizoma Curcumae Longae 15～20 weight portions, Rhizoma Acori Graminei 10～15 weight portions, Fructus Lycii 25～35 weight portions, Rhizoma Belamcandae 18～25 weight portions, Radix Paeoniae Rubra 15～25 weight portions and Radix Trichosanthis 30～50 weight portions.

2. Chinese medicine composition as claimed in claim 1, it is characterized in that: the ratio of weight and number of the raw medicinal material in described Chinese medicine composition is: Herba Sarcandrae 28 weight portions, Zaocys 12 weight portions, Herba Scutellariae Barbatae 15 weight portions, Herba Lobeliae Chinensis 15 weight portions, Herba Hedyotidis Diffusae 22 weight portions, Herba Taraxaci 35 weight portions, Herba Violae 32 weight portions, Herba Patriniae 23 weight portions, Flos Lonicerae 40 weight portions, Fructus Forsythiae 18 weight portions, Radix Glycyrrhizae 25 weight portions, Herba Lophatheri 20 weight portions, Herba Artemisiae Scopariae 15 weight portions, Radix Codonopsis 26 weight portions, Fructus Gardeniae 15 weight portions, Radix Et Rhizoma Rhei 15 weight portions, Semen Coicis 25 weight portions, Caulis Sargentodoxae 20 weight portions, Fructus Mume 30 weight portions, Borneolum Syntheticum 30 weight portions, Herba Lysimachiae 20 weight portions, Polyporus 30 weight portions, Fructus Galangae 35 weight portions, Rhizoma Curcumae Longae 20 weight portions, Rhizoma Acori Graminei 10 weight portions, Fructus Lycii 35 weight portions, Rhizoma Belamcandae 25 weight portions, Radix Paeoniae Rubra 20 weight portions and Radix Trichosanthis 35 weight portions.