CN102090876B - In vitro magnetically controlled drug release capsule system based on wireless energy supply - Google Patents

Abstract

The invention provides an in-vitro magnetic-controlled medicament delivery capsule system based on wireless energy supply, and belongs to the technical field of medical devices. The system comprises a medicament delivery capsule system, an in-vitro magnetic drive unit, an in-vitro medicament delivery device, an in-vitro wireless energy supply device and an in-vitro real-time image processing device, wherein, the medicament delivery capsule system is positioned in alimentary tract and acquires environmental information of the alimentary tract; the in-vitro medicament delivery device is connected with the medicament delivery capsule system in a wireless manner and transmits thermal therapy control information; the in-vitro real-time image processing device is connected with the medicament delivery capsule system in a wireless manner, transmits video information of capsules and outputs the information in the form of graphs; the in-vitro wireless energy supply device supplies energy to the medicament delivery capsule system in an alternating magnetic field manner; and the in-vitro magnetic drive unit and the medicament delivery capsule system realize control of posture and position of the medicament delivery capsules by means of magnetic force. By utilizing the in-vitro magnetic-controlled medicament delivery capsule system, noninvasive diagnosis and treatment of digestive tract diseases are realized in true sense under image navigation.

Description

In vitro magnetically controlled drug release capsule system based on wireless energy supply

technical field

The invention relates to a device in the technical field of medical devices, in particular to an in vitro magnetically controlled drug release capsule system based on wireless energy supply.

Background technique

Due to the accelerated pace of work and uneven diet of modern people, the incidence of digestive tract diseases is increasing day by day. Gastrointestinal diseases have become a common disease that affects the health of modern people. According to statistical analysis, digestive tract diseases are becoming younger and younger. The direction of concealment is developing. Visual detection of gastrointestinal diseases plays a very important role in the prevention, diagnosis and treatment of gastrointestinal diseases. The total length of the human digestive tract is 9 meters. Since the shape of the digestive tract is a slender pipe, it is distributed between various organs of the human body. The irregular closure of the structure brings great challenges to the clinical detection and treatment of gastrointestinal diseases.

There are mainly two types of visual detection of gastrointestinal diseases implemented clinically: gastrointestinal, colonoscopy and capsule endoscopy. Gastroscopy and colonoscopy detection are active detection, which can realize the "fixed-point" diagnosis of the whole digestive tract disease, but there may be risks of gastric trauma and intestinal trauma during the detection process of gastroscopy and colonoscopy, which will bring huge harm to the patient during the detection process. pain. Capsule endoscopy is a non-invasive detection method. After the patient takes the capsule endoscope orally, the detection of gastrointestinal diseases can be carried out without causing discomfort or pain to the patient. However, the capsule endoscope can only follow the The peristalsis of the digestive tract is used for diagnosis, and the movement of the capsule endoscope is completely passive. The diagnosis of digestive tract diseases by capsule endoscopy is also a "local" and "random" diagnosis, and cannot be actively "fixed" for digestive tract diseases. "Diagnosis, there is a large blind spot in the whole process of capsule endoscopy diagnosis, which greatly limits the clinical application of capsule endoscopy in the visual diagnosis of diseases of the whole digestive tract.

On the other hand, when the diagnosis of diseases such as digestive tract diseases is diagnosed, the treatment plan can be used clinically: for the digestive tract above the stomach and below the colon, treatment can be carried out under the video image navigation of gastroscopy and colonoscopy, but in the treatment There is still the risk of gastric trauma and intestinal trauma during the process, and the patient needs to bear great pain during the treatment process; for diseases of the digestive tract where the small intestine is located, traditional gastroscopy and enteroscopy cannot be used for treatment, and for diseases of the small intestine The treatment must be carried out by surgical methods, which is imaginable for the pain caused by the patients. Capsule endoscopy only has the function of shooting images of the digestive tract, but has no specific treatment function for digestive tract diseases, so it cannot treat digestive tract diseases.

The existing capsule endoscope system does not have the function of releasing drugs after discovering the disease; while the existing gastroscope and colonoscope have the function of "active" visual diagnosis of the whole digestive tract disease, and at the same time have the function of carrying out treatment under image navigation , but in the process of diagnosis and treatment, there are traumas and great pains for patients, and it is impossible to carry out the function of treatment in the digestive tract segment where the small intestine is located. Therefore, the existing technology cannot meet the actual needs of clinical non-invasive or minimally invasive diagnosis and treatment.

After searching the existing technology, it was found that the academic paper "Design and Research of Drug Release Microcapsule Control Circuit" published in the 8th issue of "Modern Manufacturing Engineering" in 2009 published a microcapsule for drug release in the digestive tract. Capsule structure, by controlling the miniature magnetic control switch, the medicine in the medicine compartment is released by the compressed spring.

However, the microcapsules formed by this technology have at least the following two disadvantages: first, without the aid of digestive tract image navigation, the position of drug release cannot be determined; second, the operator lacks the ability to control the posture and position of the microcapsules in vitro, and cannot actively control the microcapsules Posture and position, the limitations of the above two shortcomings make this invention patent unable to be applied to clinical practice.

Contents of the invention

Aiming at the above-mentioned deficiencies in the prior art, the present invention provides an in vitro magnetically controlled drug release capsule system based on wireless energy supply, which realizes active drive and control by an in vitro magnetic field, overcomes the "passive" operation mode of the capsule system by peristalsis of the digestive tract, At any time during the release process, the drug release capsule system can transmit the image system to the outside of the body, providing image navigation assistance for the operator's external magnetic control and drug release control, until the whole process of targeted drug release therapy at the lesion is completed.

The present invention is achieved through the following technical solutions, and the present invention includes: a drug release capsule, an external magnetic drive device, an external drug application operation device, an external wireless energy supply device and an external image real-time processing device, wherein: the drug release capsule is located in the digestive tract and Gather the environment information of the digestive tract, connect the in vitro drug application operation device with the drug releasing capsule wirelessly and transmit the hyperthermia control information, connect the in vitro image real-time processing device with the drug releasing capsule wirelessly and transmit the video information of the capsule and output it graphically, The external wireless energy supply device provides energy to the drug release capsule in the form of an alternating magnetic field, and the external magnetic drive device and the drug release capsule control the posture and position of the drug release capsule through magnetic force.

The drug release capsule includes: an analog image sensor, a lighting system, a medicine cabin and a drug release device, a casing and a main control system arranged inside it, a wireless image sending device, a digital signal wireless communication device, a rectifying device, a wireless energy receiving A coil and a permanent magnet device, wherein: the analog image sensor and the lighting system are installed at the outer end of the shell, the drug release device and the drug capsule are installed on the outer surface of the drug release capsule system shell, and the permanent magnet device is installed between the shell and the drug release device During the period, the wireless energy receiving coil receives the alternating magnetic field sent by the external wireless energy supply device and converts it into an AC electromotive force. The rectifier is connected with the wireless energy receiving coil and converts the AC electromotive force into a DC voltage. The system, the main control system, the image wireless transmission device, and the drug release device are connected and provide DC power. The image wireless transmission device directly sends the video output collected by the analog image sensor to the patient's body in a wireless manner. The main control system can control the analog image sensor. The imaging parameters are adjusted, the main control system controls the start and stop of the drug release device, and the drug release device is connected with the drug cabin. There is no electrical connection between the permanent magnet device and other parts of the drug release capsule. The permanent magnetic field generated by the permanent magnet device interacts with the permanent magnetic field of the external magnetic drive device, that is, the permanent magnetic fields of the same polarity repel each other, and the permanent magnetic fields of different polarities attract each other. Moreover, the interaction force between the permanent magnetic fields is related to its distance. By changing the distance and polarity between the permanent magnetic field polarity of the external magnetic drive device and the permanent magnetic field of the drug release capsule, it is possible to ensure that the external magnetic drive device is consistent with the posture and position of the drug release capsule. control.

The shell is in the shape of a capsule, with spherical structures at both ends.

The external magnetic drive device is a magnetic drive control device with a permanent magnet, wherein the magnetic drive control device adjusts the attitude and position of the drug release capsule by adjusting the displacement and direction between the permanent magnet and the drug release capsule.

The in vitro drug application operating device includes: remaining drug dose display screen, wireless unit and drug application operating device, wherein: the remaining drug dose display screen displays the remaining drug dose in the drug release capsule on the screen, and the drug application operating device sends Drug administration control signal, the control signal is transmitted to the drug release capsule in the digestive tract through the wireless unit, and the drug release capsule sends a control signal to the drug release device according to the control signal, and the drug release device performs drug release treatment on the lesion.

The external wireless energy supply device includes: an external wireless energy transmitting coil and a power controller, wherein: the power controller is connected to a DC or AC power supply and outputs a control signal with a sequence to the external wireless energy transmitting coil, and the external wireless energy transmitting coil The control signal is converted into an alternating electromagnetic field and output to the drug release capsule system.

The in vitro image real-time processing device includes: an in vitro image real-time receiving module and a computer workstation, wherein: the in vitro image real-time receiving module receives in real time the photographed image sent to the outside of the body by the drug release capsule system and transmits it to the computer workstation, and the computer works to display the image On the computer screen, an image navigation function is provided for the operator to realize the gesture, position control and thermal operation of the drug release capsule system.

Compared with the prior art, the present invention can actively control the posture and position of the drug release capsule in the body by the in vitro operation controller, can complete the "fixed-point" diagnosis of the digestive tract image, and realize the "targeting" operation control for the drug release operation, At the same time, the operation of actively controlling the drug release capsule in the body is carried out under the guidance of video images, realizing the non-invasive diagnosis and treatment of digestive tract diseases under the image navigation in the true sense. Compared with the existing gastroscope, colonoscope and image capsule system, the invention has obvious advantages, and the invention has very important practical application value in the diagnosis and treatment of digestive tract diseases.

Description of drawings

Fig. 1 is a schematic diagram of the working principle of the present invention.

Fig. 2 is a schematic diagram of the structure of the drug release capsule system.

Fig. 3 is a schematic diagram of the magnetic drive structure in vitro.

Fig. 4 is a schematic structural diagram of an operating device for in vitro drug administration.

Fig. 5 is a schematic diagram of an in vitro wireless energy supply device.

Fig. 6 is a schematic diagram of an in vitro image real-time processing device.

Detailed ways

The embodiments of the present invention are described in detail below. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following implementation example.

As shown in Figure 1, this implementation includes: a drug release capsule 1, an external magnetic drive device 2, an external drug application operation device 3, an external wireless energy supply device 4, and an external image real-time processing device 5, wherein: the drug release capsule 1 is located in the digester In the tract and collect the environment information of the digestive tract, the in vitro drug application operation device 3 is wirelessly connected with the drug release capsule 1 and transmits the hyperthermia control information, and the in vitro image real-time processing device 5 is wirelessly connected with the drug release capsule 1 and transmits the capsule video information And output in graphic form, the external wireless energy supply device 4 provides energy to the drug release capsule 1 in the form of an alternating magnetic field, the external magnetic drive device 2 and the drug release capsule 1 work according to the principle of permanent magnetic field interaction, that is, the permanent magnetic field of the same polarity Repel each other, the permanent magnetic fields of different polarities attract each other, and the interaction force between the permanent magnetic fields is related to its distance. By changing the distance and polarity between the permanent magnetic field polarity of the external magnetic drive device and the permanent magnetic field of the drug release capsule, the Control of attitude and position of a drug release capsule by a magnetic drive.

The drug release capsule 1 includes: an analog image sensor 6, an illumination system 7, a medicine cabin 15, a drug release device 8, a casing 9 and a main control system 10 arranged inside it, an image wireless sending device 11, a digital signal wireless communication Device 12, rectifying device 13, wireless energy receiving coil 14 and permanent magnet device 16, wherein: the lighting system 7 is installed on the outer end of the shell 9, the analog image sensor 6 is installed behind the lighting system 7, and the drug cabin 15 is installed in the drug release In the middle of the capsule, the output port of the drug release device 8 is installed on the outer surface of the drug release capsule 1 shell 9, the permanent magnet device 16 is close to the shell 9, and the wireless energy receiving coil 14 is installed at the end of the drug release capsule 1 to receive the external wireless energy supply device. 4. The alternating magnetic field sent is converted into AC electromotive force. The rectifier 13 is connected to the wireless energy receiving coil 14 and converts the AC electromotive force into a DC voltage. The rectifier 13 is respectively connected to the analog image sensor 6, the lighting system 7, the main control system 10, The image wireless sending device 11 is connected with the drug release device 8 and provides DC power. The image wireless sending device 11 directly transmits the analog video collected by the analog image sensor 6 to the outside of the patient's body in a wireless manner. The main control system 10 is connected with the analog image sensor and Realize the adjustment of the imaging parameters of the analog image sensor, the main control system 10 is connected with the digital signal wireless communication device 12 and realizes the communication with the digital wireless communication device, the main control system 10 is connected with the drug release device 8, and realizes the control of the drug release device 8 Control, the drug release device 8 is connected to the medicine cabin 15, the permanent magnet device 16 has no electrical connection with other parts of the drug release capsule, and the permanent magnet device 16 is fixed on the inner surface of the shell 9.

The shell 9 is in the shape of a capsule, with spherical structures at both ends.

The external magnetic drive device 2 in this embodiment controls the permanent magnetic field generated by the permanent magnetic device 16 in the drug release capsule 1 through the permanent magnetic field. According to the principle of permanent magnetic field interaction: permanent magnetic fields of the same polarity repel each other, and permanent magnetic fields of different polarities repel and the interaction force between the permanent magnetic fields is related to its distance. By changing the distance and polarity between the permanent magnetic field polarity of the external magnetic drive device and the permanent magnetic field of the drug release capsule, the external magnetic drive device can ensure the attitude and Position control.

In this embodiment, the drug release device 8 releases the drug in the drug chamber 15 to the surface of the lesion tissue of the digestive tract at a relatively high pressure, and can repeatedly release the drug in the drug chamber 15 .

The digital signal wireless communication device 12 in this embodiment receives the drug release control signal sent by the wireless unit 20 of the external drug administration device 3, and transmits the control signal to the main control system 10 of the drug release capsule 1, and the main control The system 10 activates the drug release device 8 to release the drug according to the control signal.

The wireless energy receiving coil 14 in this embodiment receives the alternating electromagnetic field sent by the energy transmitting coil 22 of the external wireless energy supply device 4, and converts the alternating electromagnetic field into an AC electromotive force, and the rectifying device 13 converts the AC electromotive force into a suitable DC power supply.

The permanent magnetic field generated by the permanent magnet device 16 in this embodiment interacts with the permanent magnetic field generated by the permanent magnet device 18 of the external magnetic drive device 2, the permanent magnetic fields of the same polarity repel each other, and the permanent magnetic fields of different polarities attract each other, so as to achieve The magnetic drive device 2 adjusts the attitude and position of the drug release capsule 1 .

The extracorporeal magnetic drive device 2 in this embodiment includes a permanent magnet device 18 and a magnetic drive device 17, the permanent magnet device 18 is installed on the magnetic drive device 17, wherein: the magnetic drive control device adjusts the permanent magnet device 18 and the drug release capsule 1 The displacement and direction between realize the adjustment of the posture and position of the drug release capsule 1 .

The described extracorporeal drug application operating device 3 includes a remaining drug amount display screen 19, a wireless unit 20, and a drug application control device 21, wherein: the main control system 10 of the drug release capsule 1 samples the remaining drug amount of the drug cabin 15 in real time, and the remaining drug amount is collected. The quantity is converted into a digital quantity, and the digital quantity is transmitted to the wireless unit 20 through the digital signal wireless communication device 12, and the wireless unit 20 transmits the remaining medicine quantity to the remaining medicine quantity display screen 19 and displays it, and the controller according to the remaining medicine quantity, The drug release control signal is sent by the drug application control device 21, and the control signal is transmitted to the wireless communication device 12 of the drug release capsule 1 through the wireless unit 20, and is transmitted to the main control system 10 by the wireless communication device 12, and the main control system 10 according to the control The signal activates the drug releasing device 8, and the drug releasing device 8 releases the drug in the drug chamber 15 to the pathological tissue.

The external wireless energy supply device 4 includes: an external wireless energy transmitting coil 22 and a power controller 23, wherein: the power controller 23 is connected to a DC or AC power supply and outputs a control signal with timing to the external wireless energy transmitting coil 22, The external wireless energy transmitting coil 22 converts the control signal into an alternating electromagnetic field and outputs it to the drug releasing capsule 1 .

In this embodiment, the external wireless energy transmitting coil 22 and the power controller 23 are directly connected through a specific cable, and the control signal in the power controller 23 directly drives the wireless energy transmitting coil 22 to convert electric energy into an alternating electromagnetic field.

The in vitro image real-time processing device 5 includes: an in vitro image real-time receiving module 24 and a computer workstation 25, wherein: the in vitro image real-time receiving module 24 receives in real time the photographed image sent to the outside of the body by the drug release capsule 1 and transmits it to the computer workstation 25, The computer workstation 25 displays the image on the computer screen, and provides the image navigation function for the operator to realize the posture and position control of the drug release capsule 1 and the drug release operation.

The device works in the following way: the patient swallows the drug release capsule, the external wireless energy supply device starts to work, the power controller converts the DC power into an alternating signal of a certain frequency and transmits it to the external wireless energy transmitting coil, and the external wireless energy The transmitting coil converts the electrical energy into an alternating magnetic field of a certain frequency. The alternating magnetic field is received by the wireless energy receiving coil in the drug release capsule in the body, and an alternating electromotive force is generated inside the coil. The alternating electromotive force is filtered and rectified by the rectifying device to generate DC power supply, the DC power supply provides power to the drug releasing device, the analog image sensor, the drug cabin, the main control system, the image wireless transmitting device and the digital signal wireless transmitting and receiving device. The analog image sensor, the main control system and the image wireless sending device start to work. The analog image sensor transmits the image of the digestive tract wall to the outside of the body through the image wireless transmission device, which is received by the external image real-time receiving module and transmitted to the computer workstation. The computer workstation displays the image on the screen, and the operator controls the permanent magnet control device according to the image. Changing the position and direction of the permanent magnet, the permanent magnet device of the drug release capsule in the body changes with the position and posture of the permanent magnet device outside the body, changing the position and state of the drug release capsule in the digestive tract, and the analog image sensor can detect different positions and postures The image of the lower digestive tract wall is transmitted to the outside of the body, so as to ensure that the operator can carry out "fixed-point" and "directional" diagnosis of the digestive tract under image navigation. During the diagnosis process, when a disease is found, under the guidance of the image, the operator controls the drug release capsule to stay on the surface of the disease, so that the drug release device of the drug release capsule is close to the surface of the disease, and the operator uses the in vitro drug delivery device to apply The drug control device sends a drug release operation control signal, which is transmitted to the drug release capsule through the wireless unit, received by the digital signal wireless transceiver device and transmitted to the main control system, and the main control system starts the drug release device to work, and carries out drug release on the surface of the disease. Release treatment. During the drug release process, the main control system detects the remaining drug volume in the drug cabin in real time. The main control system performs analog-to-digital conversion on the remaining drug volume and sends it to the digital signal wireless transceiver device, which then sends it to the In vitro, after the wireless unit of the external drug application operation device receives the signal of the remaining drug amount, it transmits it to the display screen of the remaining drug amount. The image releases the drug on the surface of the disease. During the drug release process, the operator can operate the external magnetic drive device to change the posture and position of the drug release capsule, and use the image navigation on the workstation to achieve all-round targeting of the drug on the lesion. freed.

Claims (6)

1. external magnetic control drugs release capsule system based on wireless energy supply; It is characterized in that; Comprise: drug release capsules, external magnetic drive unit, external dispenser operating means, external wireless energy supply device and the real-time blood processor of external image; Wherein: drug release capsules is positioned at digestive tract and gathers digestive tract environment information; External dispenser operating means is connected with wireless mode with drug release capsules and transmits the drug release control signal; The real-time blood processor of external image is connected with wireless mode with drug release capsules and transmits the capsule video information and with graphics mode output, external wireless energy supply device provides energy to drug release capsules with the alternating magnetic field mode, external magnetic drive unit and drug release capsules through the magnetic force realization to drug release capsules attitude and control of position;

Described external dispenser operating means comprises: residual drug display screen, radio-cell and dispenser operating means; Wherein: the residual drug display screen is presented at remaining dose in the drug release capsules on the display screen; The dispenser operating means sends the drug release control signal; This drug release control signal is sent to the drug release capsules in the digestive tract through radio-cell; Drug release capsules is sent the drug release device of control signal to drug release capsules according to the drug release control signal, and drug release device is carried out the drug release treatment to lesions position.

2. the external magnetic control drugs release capsule system based on wireless energy supply according to claim 1; It is characterized in that; Described drug release capsules comprises: analog image pick off, illuminator, drug release device, shell; And image wireless dispensing device, digital signal wireless communication apparatus, fairing, wireless energy receiving coil, medicine cabin, permanent magnetic device and be arranged at the master control system of enclosure; Wherein: analog image pick off and illuminator are installed in the outboard end of shell, and drug release device is installed in the outer surface of drug release capsules shell, and permanent magnetic device is installed between shell and the drug release device; The wireless energy receiving coil receives the alternating magnetic field that is sent by external wireless energy supply device and is converted into AC electromotive force; Fairing links to each other with the wireless energy receiving coil and AC electromotive force is converted into DC voltage, and with analog image pick off, illuminator, master control system, image wireless dispensing device, drug release device links to each other and dc source is provided, the image wireless dispensing device directly is sent to the analog image sensor acquisition external fairing to video image respectively; Master control system links to each other with the analog image pick off; Realization is regulated analog image pick off imaging parameters, and master control system links to each other with the digital signal wireless communication apparatus, and realization is communicated by letter with the digital signal wireless communication apparatus; Master control system links to each other with drug release device; Realization is to the control of drug release device, and drug release device links to each other with the medicine cabin, realizes the medicine in the medicine cabin is discharged into digestive tract pathology tissue surface.

3. the external magnetic control drugs release capsule system based on wireless energy supply according to claim 2 is characterized in that described shell is the capsule body shape, and both ends are chondritic.

4. the external magnetic control drugs release capsule system based on wireless energy supply according to claim 2; It is characterized in that; Described external magnetic drive unit is the magnetic driving control device with permanent magnet, and wherein: magnetic driving control device is realized the adjustment to drug release capsules attitude and position through the displacement and the direction of regulating between permanent magnet and the drug release capsules.

5. the external magnetic control drugs release capsule system based on wireless energy supply according to claim 1; It is characterized in that; Described external wireless energy supply device comprises: external wireless energy transmitting coil and power-supply controller of electric; Wherein: power-supply controller of electric links to each other with direct current or alternating current power supply and output device has the external wireless energy transmitting coil of controlling signal to of sequential, and to have the time sequence control signal transition be alternating magnetic field to external wireless energy transmitting coil and export drug release capsules to this.

6. the external magnetic control drugs release capsule system based on wireless energy supply according to claim 1; It is characterized in that; The real-time blood processor of described external image comprises: real-time receiver module of external image and computer workstation; Wherein: the real-time receiver module of external image receives in real time and is sent to external photographic images and be sent to computer workstation by drug release capsules; Computer workstation on computer screen, provides image-guidance function for the person of controling realizes drug release capsules attitude, Position Control and drug release with pictorial display.

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