CN108837176A - A kind of MULTILAYER COMPOSITE medical dressing and preparation method thereof - Google Patents
A kind of MULTILAYER COMPOSITE medical dressing and preparation method thereof Download PDFInfo
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- CN108837176A CN108837176A CN201810670102.2A CN201810670102A CN108837176A CN 108837176 A CN108837176 A CN 108837176A CN 201810670102 A CN201810670102 A CN 201810670102A CN 108837176 A CN108837176 A CN 108837176A
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- Prior art keywords
- fiber
- medical dressing
- multilayer composite
- taxol
- mass ratio
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- 239000002131 composite material Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000000835 fiber Substances 0.000 claims abstract description 103
- 229930012538 Paclitaxel Natural products 0.000 claims abstract description 52
- 229960001592 paclitaxel Drugs 0.000 claims abstract description 52
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims abstract description 51
- 229920001503 Glucan Polymers 0.000 claims abstract description 44
- 229920000742 Cotton Polymers 0.000 claims abstract description 21
- 229920000049 Carbon (fiber) Polymers 0.000 claims abstract description 20
- 229920002101 Chitin Polymers 0.000 claims abstract description 20
- 239000004917 carbon fiber Substances 0.000 claims abstract description 20
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000002253 acid Substances 0.000 claims abstract description 19
- 229920006306 polyurethane fiber Polymers 0.000 claims abstract description 19
- 150000001875 compounds Chemical class 0.000 claims abstract description 14
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940072056 alginate Drugs 0.000 claims abstract description 11
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 11
- 229920000615 alginic acid Polymers 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 9
- 230000008569 process Effects 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 46
- 239000000463 material Substances 0.000 claims description 27
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 26
- 235000010413 sodium alginate Nutrition 0.000 claims description 26
- 239000000661 sodium alginate Substances 0.000 claims description 26
- 229940005550 sodium alginate Drugs 0.000 claims description 26
- 238000006243 chemical reaction Methods 0.000 claims description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000001110 calcium chloride Substances 0.000 claims description 16
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 16
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 16
- 239000011259 mixed solution Substances 0.000 claims description 16
- 229920002307 Dextran Polymers 0.000 claims description 8
- 108010010803 Gelatin Proteins 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- 238000005516 engineering process Methods 0.000 claims description 8
- 229920000159 gelatin Polymers 0.000 claims description 8
- 239000008273 gelatin Substances 0.000 claims description 8
- 235000019322 gelatine Nutrition 0.000 claims description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims description 8
- 230000001376 precipitating effect Effects 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 8
- 238000002166 wet spinning Methods 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 7
- 241000209094 Oryza Species 0.000 claims 2
- 235000007164 Oryza sativa Nutrition 0.000 claims 2
- 235000009566 rice Nutrition 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 125000002456 taxol group Chemical group 0.000 claims 1
- 230000029663 wound healing Effects 0.000 abstract description 6
- 230000035699 permeability Effects 0.000 abstract description 4
- 241001474374 Blennius Species 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000000474 nursing effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000002121 nanofiber Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of MULTILAYER COMPOSITE medical dressing, which is characterized in that the MULTILAYER COMPOSITE medical dressing outermost layer is cotton fiber, carbon fiber mixing, is made through needling process；Middle layer, which is alginate fibre, acid fiber by polylactic is compound is made；Skin-friendly layer is that taxol/glucan micro nanometer fiber, chitin fiber and polyurethane fiber are compound, is made through needling process.The invention also discloses the preparation methods of the MULTILAYER COMPOSITE medical dressing.Medical dressing stability produced by the present invention is good, soft comfortable, good permeability, and can effectively facilitate wound healing.
Description
Technical field：
The present invention relates to field of medical materials, are specifically related to a kind of MULTILAYER COMPOSITE medical dressing.
Background technique：
The either nursing of postoperative wound or the wound for diabetic foot ulcer, large-area burns and deep tissue infection
Mouth nursing is all focus nowadays clinically.Covering of the medical dressing as wound, can substitute impaired skin
Temporary barrier action is played, the environment conducive to wound healing is provided with.The use of medical dressing not only shortens wound healing
Time reduces the waste of resource, also significantly reduces medical workload, meets patient requests.Therefore clinically selection is closed
The medical dressing of suitable high quality is particularly important.
The effect of medical dressing is mainly isolated the surface of a wound, is protected, while adhering to drug, absorbing body fluid etc., therefore
Dressing must have superior water imbibition, gas permeability and with comfort when skin contact.China largely uses for a long time
Medical dressing be all to be folded by cotton gauze, there is apparent defect in use.
Summary of the invention：
The object of the present invention is to provide a kind of MULTILAYER COMPOSITE medical dressing, the medical dressing good permeability, soft comfortable resists
Bacterium has excellent performance, and can effectively facilitate wound healing, improves healing quality.
It is a further object to provide the preparation methods of the MULTILAYER COMPOSITE medical dressing.
To achieve the above object, the present invention uses following technical scheme：
A kind of MULTILAYER COMPOSITE medical dressing, which is cotton fiber, carbon fiber mixing, through needle
Technique is pierced to be made；Middle layer, which is alginate fibre, acid fiber by polylactic is compound is made；Skin-friendly layer is the micro-nano fibre of taxol/glucan
Dimension, chitin fiber and polyurethane fiber are compound, are made through needling process.
As a preferred embodiment of the above technical solution, cotton fiber, carbon fiber mass ratio be (1-3)：1.
As a preferred embodiment of the above technical solution, the alginate fibre, acid fiber by polylactic mass ratio be 5：(1-2).
As a preferred embodiment of the above technical solution, the taxol/glucan micro nanometer fiber, chitin fiber and polyurethane
The mass ratio of fiber is (0.5-1.5)：2：(5-10).
A kind of preparation method of MULTILAYER COMPOSITE medical dressing, includes the following steps：
(1) cotton fiber and carbon fiber are mixed to prepare dressing outermost layer；
(2) sodium alginate, calcium chloride are dissolved in deionized water obtained solution, seaweed is then made using wet spinning technology
Sodium alginate fiber and acid fiber by polylactic are mixed to prepare composite fibre, and middle layer are made using it as raw material by sour sodium fiber；
(3) taxol, glucan are dissolved in water respectively and paclitaxel solution and dextran solution is made；Then it is mixed system
Mixed solution is obtained, and the pH to 5-6 that citric acid solution adjusts mixed solution is added；It is stirred to react at 5-8 DEG C, after reaction
Centrifugal treating, obtained precipitating vacuum drying, is made taxol/glucan micro nanometer fiber；By taxol/glucan obtained
Micro nanometer fiber and chitin fiber, polyurethane fiber are mixed with skin-friendly layer；
(4) above-mentioned pro-skin layer material is placed in ethanol solution and maleic anhydride is then added, be to slowly warm up to 50-80 DEG C,
Back flow reaction filters after reaction, and modified skin-friendly layer is made；
(5) by material obtained above using compound obtained medical dressing is laminated, between layers using gelatin as viscous
Tie agent.
As a preferred embodiment of the above technical solution, in step (2), the sodium alginate, calcium chloride mass ratio be 1：(0.1-
0.7)。
As a preferred embodiment of the above technical solution, in step (3), the taxol, glucan mass ratio be 1：(3-5).
As a preferred embodiment of the above technical solution, in step (4), the pro-skin layer material, maleic anhydride mass ratio be 10：
(1-2)。
The invention has the advantages that：
MULTILAYER COMPOSITE medical dressing outermost layer disclosed by the invention is using cotton fiber and carbon fiber as material, not only wearability
It is good, and there is certain antistatic property；Sodium alginate fiber fluffy made from middle layer is comfortable, mixes with acid fiber by polylactic,
With good water suction water vapour permeability；Pro-skin layer material be homemade taxol/glucan micro nanometer fiber and chitin fiber,
Polyurethane fiber not only has certain anti-microbial property, and mechanical property is good, and modified pro-skin layer material has good
Performance of keeping humidity, wettability is good, can effectively facilitate wound healing, improves wound healing quality.
Method disclosed by the invention is easy to operate, biodegradable, environment-protecting and non-poisonous, and preparation cost is low.
Specific embodiment：
In order to better understand the present invention, below by embodiment, the present invention is further described, and embodiment is served only for solving
The present invention is released, any restriction will not be constituted to the present invention.
Embodiment 1
A kind of preparation method of MULTILAYER COMPOSITE medical dressing, includes the following steps：
(1) cotton fiber and carbon fiber are mixed to prepare dressing outermost layer；Wherein, cotton fiber, carbon fiber mass ratio be 1：
1；
(2) sodium alginate, calcium chloride are dissolved in deionized water obtained solution, seaweed is then made using wet spinning technology
Sodium alginate fiber and acid fiber by polylactic are mixed to prepare composite fibre, and middle layer are made using it as raw material by sour sodium fiber；Its
In, alginate fibre, acid fiber by polylactic mass ratio be 5：1；Sodium alginate, calcium chloride mass ratio be 1：0.1；
(3) taxol, glucan are dissolved in water respectively and paclitaxel solution and dextran solution is made；Then it is mixed system
Mixed solution is obtained, and the pH to 5-6 that citric acid solution adjusts mixed solution is added；It is stirred to react at 5-8 DEG C, after reaction
Centrifugal treating, obtained precipitating vacuum drying, is made taxol/glucan micro nanometer fiber；By taxol/glucan obtained
Micro nanometer fiber and chitin fiber, polyurethane fiber are mixed with skin-friendly layer；Wherein, taxol/glucan micro nanometer fiber,
The mass ratio of chitin fiber and polyurethane fiber is 0.5：2：5；Taxol, glucan mass ratio be 1：3；
(4) above-mentioned pro-skin layer material is placed in ethanol solution and maleic anhydride is then added, be to slowly warm up to 50 DEG C, reflux
Reaction, is filtered after reaction, and modified skin-friendly layer is made；Wherein, pro-skin layer material, maleic anhydride mass ratio be 10：1；
(5) by material obtained above using compound obtained medical dressing is laminated, between layers using gelatin as viscous
Tie agent.
Embodiment 2
A kind of preparation method of MULTILAYER COMPOSITE medical dressing, includes the following steps：
(1) cotton fiber and carbon fiber are mixed to prepare dressing outermost layer；Wherein, cotton fiber, carbon fiber mass ratio be 3：
1；
(2) sodium alginate, calcium chloride are dissolved in deionized water obtained solution, seaweed is then made using wet spinning technology
Sodium alginate fiber and acid fiber by polylactic are mixed to prepare composite fibre, and middle layer are made using it as raw material by sour sodium fiber；Its
In, alginate fibre, acid fiber by polylactic mass ratio be 5：2；Sodium alginate, calcium chloride mass ratio be 1：0.7；
(3) taxol, glucan are dissolved in water respectively and paclitaxel solution and dextran solution is made；Then it is mixed system
Mixed solution is obtained, and the pH to 5-6 that citric acid solution adjusts mixed solution is added；It is stirred to react at 5-8 DEG C, after reaction
Centrifugal treating, obtained precipitating vacuum drying, is made taxol/glucan micro nanometer fiber；By taxol/glucan obtained
Micro nanometer fiber and chitin fiber, polyurethane fiber are mixed with skin-friendly layer；Wherein, taxol/glucan micro nanometer fiber,
The mass ratio of chitin fiber and polyurethane fiber is 1.5：2：10；Taxol, glucan mass ratio be 1：5；
(4) above-mentioned pro-skin layer material is placed in ethanol solution and maleic anhydride is then added, be to slowly warm up to 80 DEG C, reflux
Reaction, is filtered after reaction, and modified skin-friendly layer is made；Wherein, pro-skin layer material, maleic anhydride mass ratio be 10：2；
(5) by material obtained above using compound obtained medical dressing is laminated, between layers using gelatin as viscous
Tie agent.
Embodiment 3
A kind of preparation method of MULTILAYER COMPOSITE medical dressing, includes the following steps：
(1) cotton fiber and carbon fiber are mixed to prepare dressing outermost layer；Wherein, cotton fiber, carbon fiber mass ratio be
1.5：1；
(2) sodium alginate, calcium chloride are dissolved in deionized water obtained solution, seaweed is then made using wet spinning technology
Sodium alginate fiber and acid fiber by polylactic are mixed to prepare composite fibre, and middle layer are made using it as raw material by sour sodium fiber；Its
In, alginate fibre, acid fiber by polylactic mass ratio be 5：1.2；Sodium alginate, calcium chloride mass ratio be 1：0.2；
(3) taxol, glucan are dissolved in water respectively and paclitaxel solution and dextran solution is made；Then it is mixed system
Mixed solution is obtained, and the pH to 5-6 that citric acid solution adjusts mixed solution is added；It is stirred to react at 5-8 DEG C, after reaction
Centrifugal treating, obtained precipitating vacuum drying, is made taxol/glucan micro nanometer fiber；By taxol/glucan obtained
Micro nanometer fiber and chitin fiber, polyurethane fiber are mixed with skin-friendly layer；Wherein, taxol/glucan micro nanometer fiber,
The mass ratio of chitin fiber and polyurethane fiber is 0.7：2：6；Taxol, glucan mass ratio be 1：3.5；
(4) above-mentioned pro-skin layer material is placed in ethanol solution and maleic anhydride is then added, be to slowly warm up to 55 DEG C, reflux
Reaction, is filtered after reaction, and modified skin-friendly layer is made；Wherein, pro-skin layer material, maleic anhydride mass ratio be 10：1.2；
(5) by material obtained above using compound obtained medical dressing is laminated, between layers using gelatin as viscous
Tie agent.
Embodiment 4
A kind of preparation method of MULTILAYER COMPOSITE medical dressing, includes the following steps：
(1) cotton fiber and carbon fiber are mixed to prepare dressing outermost layer；Wherein, cotton fiber, carbon fiber mass ratio be
1.5：1；
(2) sodium alginate, calcium chloride are dissolved in deionized water obtained solution, seaweed is then made using wet spinning technology
Sodium alginate fiber and acid fiber by polylactic are mixed to prepare composite fibre, and middle layer are made using it as raw material by sour sodium fiber；Its
In, alginate fibre, acid fiber by polylactic mass ratio be 5：1.2；Sodium alginate, calcium chloride mass ratio be 1：0.2；
(3) taxol, glucan are dissolved in water respectively and paclitaxel solution and dextran solution is made；Then it is mixed system
Mixed solution is obtained, and the pH to 5-6 that citric acid solution adjusts mixed solution is added；It is stirred to react at 5-8 DEG C, after reaction
Centrifugal treating, obtained precipitating vacuum drying, is made taxol/glucan micro nanometer fiber；By taxol/glucan obtained
Micro nanometer fiber and chitin fiber, polyurethane fiber are mixed with skin-friendly layer；Wherein, taxol/glucan micro nanometer fiber,
The mass ratio of chitin fiber and polyurethane fiber is 0.7：2：7；Taxol, glucan mass ratio be 1：4；
(4) above-mentioned pro-skin layer material is placed in ethanol solution and maleic anhydride is then added, be to slowly warm up to 60 DEG C, reflux
Reaction, is filtered after reaction, and modified skin-friendly layer is made；Wherein, pro-skin layer material, maleic anhydride mass ratio be 10：1.4；
(5) by material obtained above using compound obtained medical dressing is laminated, between layers using gelatin as viscous
Tie agent.
Embodiment 5
A kind of preparation method of MULTILAYER COMPOSITE medical dressing, includes the following steps：
(1) cotton fiber and carbon fiber are mixed to prepare dressing outermost layer；Wherein, cotton fiber, carbon fiber mass ratio be 2：
1；
(2) sodium alginate, calcium chloride are dissolved in deionized water obtained solution, seaweed is then made using wet spinning technology
Sodium alginate fiber and acid fiber by polylactic are mixed to prepare composite fibre, and middle layer are made using it as raw material by sour sodium fiber；Its
In, alginate fibre, acid fiber by polylactic mass ratio be 5：1.6；Sodium alginate, calcium chloride mass ratio be 1：0.3；
(3) taxol, glucan are dissolved in water respectively and paclitaxel solution and dextran solution is made；Then it is mixed system
Mixed solution is obtained, and the pH to 5-6 that citric acid solution adjusts mixed solution is added；It is stirred to react at 5-8 DEG C, after reaction
Centrifugal treating, obtained precipitating vacuum drying, is made taxol/glucan micro nanometer fiber；By taxol/glucan obtained
Micro nanometer fiber and chitin fiber, polyurethane fiber are mixed with skin-friendly layer；Wherein, taxol/glucan micro nanometer fiber,
The mass ratio of chitin fiber and polyurethane fiber is 0.9：2：8；Taxol, glucan mass ratio be 1：4；
(4) above-mentioned pro-skin layer material is placed in ethanol solution and maleic anhydride is then added, be to slowly warm up to 70 DEG C, reflux
Reaction, is filtered after reaction, and modified skin-friendly layer is made；Wherein, pro-skin layer material, maleic anhydride mass ratio be 10：1.6；
(5) by material obtained above using compound obtained medical dressing is laminated, between layers using gelatin as viscous
Tie agent.
Embodiment 6
A kind of preparation method of MULTILAYER COMPOSITE medical dressing, includes the following steps：
(1) cotton fiber and carbon fiber are mixed to prepare dressing outermost layer；Wherein, cotton fiber, carbon fiber mass ratio be
2.5：1；
(2) sodium alginate, calcium chloride are dissolved in deionized water obtained solution, seaweed is then made using wet spinning technology
Sodium alginate fiber and acid fiber by polylactic are mixed to prepare composite fibre, and middle layer are made using it as raw material by sour sodium fiber；Its
In, alginate fibre, acid fiber by polylactic mass ratio be 5：1.8；Sodium alginate, calcium chloride mass ratio be 1：0.6；
(3) taxol, glucan are dissolved in water respectively and paclitaxel solution and dextran solution is made；Then it is mixed system
Mixed solution is obtained, and the pH to 5-6 that citric acid solution adjusts mixed solution is added；It is stirred to react at 5-8 DEG C, after reaction
Centrifugal treating, obtained precipitating vacuum drying, is made taxol/glucan micro nanometer fiber；By taxol/glucan obtained
Micro nanometer fiber and chitin fiber, polyurethane fiber are mixed with skin-friendly layer；Wherein, taxol/glucan micro nanometer fiber,
The mass ratio of chitin fiber and polyurethane fiber is 1.1：2：9；Taxol, glucan mass ratio be 1：4.5；
(4) above-mentioned pro-skin layer material is placed in ethanol solution and maleic anhydride is then added, be to slowly warm up to 75 DEG C, reflux
Reaction, is filtered after reaction, and modified skin-friendly layer is made；Wherein, pro-skin layer material, maleic anhydride mass ratio be 10：1.8；
(5) by material obtained above using compound obtained medical dressing is laminated, between layers using gelatin as viscous
Tie agent.
Through detecting, medical dressing produced by the present invention is to the bacteriostasis rate of Escherichia coli and staphylococcus aureus
98.5% or more.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (8)
1. a kind of MULTILAYER COMPOSITE medical dressing, it is characterised in that：The MULTILAYER COMPOSITE medical dressing outermost layer is cotton fiber, carbon fiber
Mixing is made through needling process；Middle layer, which is alginate fibre, acid fiber by polylactic is compound is made；Skin-friendly layer is taxol/glucan
Micro nanometer fiber, chitin fiber and polyurethane fiber are compound, are made through needling process.
2. a kind of MULTILAYER COMPOSITE medical dressing as described in claim 1, it is characterised in that：The mass ratio of cotton fiber, carbon fiber
For (1-3)：1.
3. a kind of MULTILAYER COMPOSITE medical dressing as described in claim 1, it is characterised in that：The alginate fibre, polylactic acid are fine
The mass ratio of dimension is 5：(1-2).
4. a kind of MULTILAYER COMPOSITE medical dressing as described in claim 1, it is characterised in that：The taxol/glucan micro-nano
The mass ratio of rice fiber, chitin fiber and polyurethane fiber is (0.5-1.5)：2：(5-10).
5. a kind of preparation method of MULTILAYER COMPOSITE medical dressing as described in Claims 1-4 is any, which is characterized in that including
Following steps：
(1) cotton fiber and carbon fiber are mixed to prepare dressing outermost layer；
(2) sodium alginate, calcium chloride are dissolved in deionized water obtained solution, sodium alginate is then made using wet spinning technology
Sodium alginate fiber and acid fiber by polylactic are mixed to prepare composite fibre, and middle layer are made using it as raw material by fiber；
(3) taxol, glucan are dissolved in water respectively and paclitaxel solution and dextran solution is made；Then it is mixed and is made mixed
Solution is closed, and the pH to 5-6 that citric acid solution adjusts mixed solution is added；It is stirred to react at 5-8 DEG C, is centrifuged after reaction
Processing, obtained precipitating vacuum drying, is made taxol/glucan micro nanometer fiber；By taxol obtained/glucan micro-nano
Rice fiber and chitin fiber, polyurethane fiber are mixed with skin-friendly layer；
(4) above-mentioned pro-skin layer material is placed in ethanol solution and maleic anhydride is then added, be to slowly warm up to 50-80 DEG C, reflux
Reaction, is filtered after reaction, and modified skin-friendly layer is made；
(5) by material obtained above using compound obtained medical dressing is laminated, between layers using gelatin as binder.
6. a kind of preparation method of MULTILAYER COMPOSITE medical dressing as claimed in claim 5, it is characterised in that：In step (2), institute
State sodium alginate, the mass ratio of calcium chloride is 1：(0.1-0.7).
7. a kind of preparation method of MULTILAYER COMPOSITE medical dressing as claimed in claim 5, it is characterised in that：In step (3), institute
State taxol, the mass ratio of glucan is 1：(3-5).
8. a kind of preparation method of MULTILAYER COMPOSITE medical dressing as claimed in claim 5, it is characterised in that：In step (4), institute
State pro-skin layer material, the mass ratio of maleic anhydride is 10：(1-2).
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115075043A (en) * | 2022-06-16 | 2022-09-20 | 东华大学 | Preparation method of kapok-based dressing |
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