CN108159191B - Composition for tonifying yang and invigorating kidney, application and oral liquid and preparation method thereof - Google Patents

Abstract

The invention provides a composition for tonifying yang and kidney, an application thereof, an oral liquid and a preparation method thereof, and relates to the field of health care products. The oral liquid prepared from the composition has the same effect and is convenient to eat. The preparation method of the oral liquid can make the raw materials give full play to the effect, and has industrial value. The invention solves the problem that the prior art is lack of a health-care product which can effectively relieve the sub-health state of men and has the functions of tonifying yang and invigorating kidney.

Description

Composition for tonifying yang and invigorating kidney, application and oral liquid and preparation method thereof

Technical Field

The invention relates to the field of health care products, in particular to a composition for tonifying yang and invigorating kidney, application, an oral liquid and a preparation method thereof.

Background

Men are increasingly experiencing health and sub-health problems. According to the world health organization survey, 78% of urban men have physical and mental health problems or are in a "sub-healthy" state. In the "sub-healthy" population, men account for up to 75%.

Modern men have five major pain points in health: firstly, the kidney deficiency and kidney deficiency, waist soreness and leg sleepiness, lower limb weakness, qi fatigue and mental fatigue, mental deficiency, sexual function hypofunction or disorder caused by long-term stress are caused, and the physical and mental health and family harmony are influenced. And secondly, the health risks of qi deficiency, weight excess, high blood pressure, blood sugar, blood fat and uric acid, cancer, hypertension, diabetes, gout, cardiovascular and cerebrovascular diseases, sudden death and the like are greatly increased due to long-term overload work, diet, irregular work and rest and insufficient exercise. Thirdly, the stress of work and family causes the spirit to enter into an overload running state, the mental fatigue and the shortness of breath, the mental stress, the anxiety, the melancholy and the loneliness are caused, and the emotion is repeated. Medical clinical practice and scientific research prove that negative emotions such as anxiety, hate, sadness, fear, anger and the like can cause dysfunction of all systems of a human body, and can cause poor physical responses such as amnesia, insomnia, tachycardia, blood pressure rise, anorexia, giddiness, body and mind fatigue and the like. If a human body is in a sub-healthy state for a long time, substantial pathological changes can be easily caused. And fourthly, bad living habits and hobbies such as drinking, reward and smoking and the like cause substantial pathological changes on the heart, the liver, the lung and the pancreas, and a series of body adverse reactions occur. After a long time, the incidence of various high-risk diseases such as cancer, high disease, cardiovascular and cerebrovascular diseases, kidney diseases, liver diseases, prostate, sexual dysfunction and the like is very high, the health hidden danger of middle-aged men is very large, and the risk of illness and death is very high. And fifthly, the urban natural environment and working environment deteriorate, highly polluted air, various harmful substances and heavy residual food, various noise interferences, computers, mobile phones, various high electromagnetic radiations, waste water, waste gas, noise, radiation and the like cause great harm to the physical and mental health of men, and various internal organs are heavily burdened and often overwhelmed, so that pathological changes are easily generated, and great threat to health is formed.

Therefore, there is a need to provide a health product for tonifying yang and invigorating kidney to alleviate the sub-health problem of men.

In view of the above, the present invention is particularly proposed.

Disclosure of Invention

The first purpose of the invention is to provide a composition for tonifying yang and invigorating kidney, the second purpose of the invention is to provide the application of the composition in preparing health care products and medicines, the third purpose of the invention is to provide an oral liquid using the composition as a raw material, and the fourth purpose of the invention is to provide a preparation method of the oral liquid, which solves the problem that the prior art lacks of a health care product which can effectively relieve the sub-health state of men and has the effect of tonifying yang and invigorating kidney.

In order to solve the technical problems, the invention adopts the following technical scheme:

the composition for tonifying yang and invigorating kidney comprises the following components in parts by weight: 25-250 parts of black wolfberry, 5-55 parts of black maca, 5-20 parts of cistanche, 5-15 parts of cordyceps sinensis, 10-20 parts of eucommia ulmoides, 5-10 parts of lucid ganoderma, 5-15 parts of cynomorium songaricum, 5-10 parts of lotus seeds, 2-10 parts of snow chrysanthemum, 5-15 parts of hawthorn, 5-15 parts of American ginseng, 15-120 parts of red wolfberry and 5-15 parts of honey.

Further, the lycium ruthenicum comprises a dried lycium ruthenicum and/or a fresh lycium ruthenicum; and/or the red medlar comprises a dry red medlar product and/or a fresh red medlar product;

preferably, the composition comprises 25 to 50 parts by weight of the dried lycium ruthenicum murr, preferably 25 to 40 parts by weight, more preferably 25 to 35 parts by weight;

preferably, the composition comprises 50-200 parts by weight of the fresh lycium ruthenicum murr, preferably 100-200 parts by weight, and more preferably 150-200 parts by weight;

preferably, the composition comprises dried lycium ruthenicum 15-45 parts by weight, preferably 15-35 parts by weight, more preferably 18-25 parts by weight;

preferably, the composition comprises 45 to 75 parts by weight of fresh lycium ruthenicum murr, preferably 50 to 65 parts by weight, more preferably 55 to 65 parts by weight.

Further, the composition also comprises one or more of pseudo-ginseng, ginseng and acanthopanax;

preferably, the composition comprises 5 to 15 parts by weight of notoginseng, preferably 8 to 12 parts by weight, more preferably 9 to 11 parts by weight;

preferably, the composition comprises 2 to 10 parts by weight of ginseng, preferably 4 to 9 parts by weight, more preferably 5 to 8 parts by weight;

preferably, the composition comprises acanthopanax senticosus 5-20 parts by weight, preferably 8-15 parts by weight, more preferably 9-12 parts by weight.

Further, the honey comprises medlar nectar.

Further, the composition comprises 8-30 parts by weight of black maca, 6-15 parts by weight of cistanche, 6-10 parts by weight of cordyceps sinensis, 12-18 parts by weight of eucommia ulmoides, 6-9 parts by weight of lucid ganoderma, 7-12 parts by weight of cynomorium songaricum, 6-9 parts by weight of lotus seed, 3-8 parts by weight of coreopsis tinctoria, 8-12 parts by weight of hawthorn, 6-12 parts by weight of American ginseng and 8-12 parts by weight of honey;

preferably, the composition comprises 8-15 parts of black maca, 8-12 parts of cistanche, 7-11 parts of cordyceps sinensis, 14-16 parts of eucommia ulmoides, 7-8 parts of lucid ganoderma, 8-11 parts of cynomorium songaricum, 7-9 parts of lotus seed, 4-6 parts of coreopsis tinctoria, 9-11 parts of hawthorn, 7-10 parts of American ginseng and 9-11 parts of honey.

The application of the composition in preparing health products and medicines comprises fatigue resistance, oxidation resistance, yang strengthening and kidney invigorating.

An oral liquid, the raw materials of the oral liquid comprise the composition.

Further, the raw material comprises one or more of a raw material slurry, a soaking solution of the raw material and an extract of the raw material.

The preparation method of the oral liquid comprises the step of mixing the raw materials according to the formula amount.

Further, the preparation method comprises the following steps:

(a) pulverizing maca, herba cistanches, herba Cynomorii, radix Panacis Quinquefolii, fructus Lycii, snow chrysanthemum, cortex Eucommiae, semen Nelumbinis, and fructus crataegi respectively, soaking, and squeezing to obtain juice;

(b) crushing the ganoderma lucidum to 100-one 120 meshes;

(c) mixing the components in the step (a) and the step (b), honey and the cordyceps sinensis extract according to the formula amount, filtering and sterilizing;

preferably, the raw material treated in step (a) further comprises one or more of ginseng, notoginseng and acanthopanax;

preferably, the step (a) further comprises the steps of: crushing and soaking the components, pulping, juicing, and sequentially performing centrifugal separation, degassing, filtering, sterilizing and vacuum concentration on the juice obtained after juicing to obtain the raw material pulp of each component.

Compared with the prior art, the invention has the following beneficial effects:

the composition for tonifying yang and invigorating kidney provided by the invention comprises lycium ruthenicum, maca, cistanche, cordyceps sinensis, eucommia ulmoides, ganoderma lucidum, cynomorium songaricum, lotus seeds, coreopsis tinctoria, hawthorn, American ginseng, lycium ruthenicum and honey. The composition can supplement high-quality anthocyanidin with sufficient amount of Lycium ruthenicum Murr, enhance immunity, improve antioxidant and antiaging capability of human body, scavenge free radicals, relieve asthenopia, care skin, balance endocrine, protect cardiovascular and cerebrovascular system, and improve internal circulation of human body. The composition is prepared from maca, herba cistanches, cortex eucommiae, and herba cynomorii for warming and invigorating kidney, nourishing yin and tonifying yang, and strengthening waist and invigorating kidney; fructus lycii, cordyceps sinensis, lucid ganoderma, American ginseng and honey are used for nourishing essence, qi and blood and various body deficiency and vacuity, regulating and nourishing qi and blood and strengthening physique; lotus seed, snow chrysanthemum and hawthorn are used for regulating the heat property of the whole formula, so that the effects of no dryness and no cold, smooth and mild nourishing, clearing away garbage toxin generated by the body, expelling toxin, beautifying, reducing blood fat and blood sugar, promoting blood circulation to remove blood stasis, clearing away the heart fire and soothing the nerves are achieved. The components can enhance constitution through synergistic effect, and has effects of resisting aging, resisting oxidation, scavenging free radicals, warming and invigorating kidney yang, regulating and invigorating qi and blood, regulating yin and yang balance, removing toxic substance, caring skin, clearing heart fire, and tranquilizing mind.

The composition provided by the invention can be used for preparing health products and medicines, and comprises the functions of resisting fatigue, resisting oxidation, tonifying yang and invigorating kidney. The composition can be used for preparing various health products or medicines for relieving sub-health of men, health products in various forms such as health wine, health oral liquid and the like, and Chinese patent medicines in various forms such as pills, paste or tablets and the like.

The oral liquid provided by the invention takes the traditional Chinese medicine composition as a raw material, has all health care effects of the composition, and also has the advantage of convenience in drinking.

The preparation method of the oral liquid provided by the invention well maintains the health care and treatment effects of the raw material medicines, is suitable for large-scale production, and has great industrial value.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

Fig. 1 is a process flow for preparing an oral liquid provided in embodiment 6 of the present invention.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments and the accompanying drawings, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a composition for tonifying yang and invigorating kidney, which comprises the following components in parts by weight: 25-250 parts of black wolfberry, 5-55 parts of black maca, 5-20 parts of cistanche, 5-15 parts of cordyceps sinensis, 10-20 parts of eucommia ulmoides, 5-10 parts of lucid ganoderma, 5-15 parts of cynomorium songaricum, 5-10 parts of lotus seeds, 2-10 parts of snow chrysanthemum, 5-15 parts of hawthorn, 5-15 parts of American ginseng, 15-120 parts of red wolfberry and 5-15 parts of honey.

The traditional Chinese medicine holds that the black food (medicine) enters the kidney, which means that the black food has the health care function of strengthening the kidney. The invention preferably uses three black medicinal (edible) raw materials of black medlar, black maca and desertliving cistanche produced by the Bupleurum chinense basin of Qinghai province as the pharmacological basis of the whole formula for resisting oxidation, resisting aging, tonifying yang and invigorating kidney.

Aiming at the physical condition of middle-aged men, the composition provides basic effects by using anthocyanin, and sufficient black wolfberry is used for supplementing high-quality anthocyanin of a human body, enhancing the immunity of the human body, improving the capabilities of the organism in resisting oxidation and aging and removing free radicals of the human body, and also has the effects of relieving visual fatigue, maintaining beauty and keeping young, balancing endocrine of the body, protecting cardiovascular and cerebrovascular systems and improving internal circulation of the human body; the black maca, the cistanche, the eucommia bark and the cynomorium songaricum are used for warming and nourishing the kidney, nourishing yin and strengthening yang, and strengthening the waist and the kidney; fructus lycii, cordyceps sinensis, lucid ganoderma, American ginseng and honey are used for nourishing essence, qi and blood and various body deficiency and vacuity, regulating and nourishing qi and blood and strengthening physique; the lotus seed, the snow chrysanthemum and the hawthorn are used for regulating the heat property of the whole formula, so that the effects of no dryness and no cold, smooth and mild nourishing, clearing away garbage toxin generated by a body, expelling toxin and beautifying, reducing blood fat and blood sugar, promoting blood circulation to remove blood stasis and clearing away the heart fire and soothing the nerves are achieved, and the effects of strengthening the body, resisting aging and oxidation, clearing free radicals of a human body, warming and invigorating kidney yang, regulating and invigorating qi and blood, regulating the balance of yin and yang of the human body, expelling toxin and beautifying the skin and clearing away the heart fire and soothing the nerves of the whole formula are exerted through.

In an alternative embodiment, the lycium ruthenicum comprises a dried lycium ruthenicum and/or a fresh lycium ruthenicum; optionally, the composition comprises 25 to 50 parts by weight of dried lycium ruthenicum, for example, but not limited to, 20, 25, 30, 40 or 50 parts by weight, preferably 25 to 35 parts by weight; optionally, the composition comprises 50-200 parts by weight of fresh lycium ruthenicum murr, such as but not limited to 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190 or 200 parts by weight, preferably 150-200 parts by weight.

In an alternative embodiment, the lycium ruthenicum comprises a dried lycium ruthenicum and/or a fresh lycium ruthenicum; optionally, the composition comprises dried lycium ruthenicum 15-45 parts by weight, such as but not limited to 15, 25, 35 or 45 parts by weight, preferably 18-25 parts by weight; optionally, the composition comprises fresh lycium ruthenicum 45-75 parts by weight, such as but not limited to 45, 50, 60, 70 or 75 parts by weight, preferably 55-65 parts by weight.

In an alternative embodiment, the black maca may be, for example but not limited to, 5, 15, 25, 40 or 55 parts by weight, preferably 8 to 15 parts by weight; optionally, the cistanche salsa can be, for example, but not limited to, 5, 15 or 20 parts by weight, preferably 8 to 12 parts by weight; optionally, the cordyceps sinensis can be, but is not limited to, 5, 10 or 15 parts by weight, preferably 7-11 parts by weight; optionally, the eucommia ulmoides may be, for example, but not limited to, 10, 12, 15 or 20 parts by weight, preferably 14 to 16 parts by weight; optionally, the ganoderma lucidum may be, for example, but not limited to, 5, 8 or 10 parts by weight, preferably 7 to 8 parts by weight; alternatively, the cynomorium songaricum may be, for example, but not limited to, 5, 10, 12, 15 or 20 parts by weight, preferably 8 to 11 parts by weight; alternatively, the lotus seed may be, for example but not limited to, 5, 8 or 10 parts by weight, preferably 7 to 9 parts by weight; alternatively, the coreopsis tinctoria may be, for example, but not limited to, 2, 8, or 10 parts by weight, preferably 4 to 6 parts by weight; alternatively, the hawthorn may be, for example, but not limited to, 5, 10, 12, 15, or 20 parts by weight, preferably 9-11 parts by weight; optionally, the American ginseng may be, for example, but not limited to, 5, 10, 12, 15 or 20 parts by weight, preferably 7 to 10 parts by weight; optionally, the honey may be, for example but not limited to, 5, 10 or 15 parts by weight, preferably 9-11 parts by weight.

The composition for tonifying yang and invigorating kidney provided by the invention has the following effects:

black wolfberry fruit: lycium ruthenicum contains a large amount of anthocyanin which is a powerful antioxidant and can maintain normal cell connection and blood vessel stability, promote the circulation of blood capillaries and improve the flow of blood capillaries and veins. In mature purple black berries of lycium ruthenicum, more than 20 kinds of anthocyanin ingredients are contained, wherein 6 major types such as cyanidin, petunidin and the like are mainly contained, and the anthocyanin has the following six effects: the anthocyanin has the effect of eliminating free radicals and can prevent cancer cells from diffusing smoothly, so that more healthy cells are protected from being eroded by the cancer cells. Secondly, the vision is improved, the anthocyanin can promote the regeneration of rhodopsin in retinal cells, promote the visual acuity, prevent severe myopia and retinal detachment, improve the vision and have certain antagonism on the damage of retinal ganglion cells. The anthocyanin can prevent the skin wrinkles from generating in advance, can supplement nutrition and eliminate harmful free radicals in vivo, can prevent ultraviolet rays from invading the skin, and can inhibit the activity of tyrosinase in the skin; can reduce the o-benzoquinone structure of melanin into a phenol structure, so that the pigment is faded and the skin is whitened; can inhibit Maillard reaction due to protein amino group and nucleic acid amino group, thereby inhibiting formation of lipofuscin and senile plaque; can have synergistic effect with vitamin C or vitamin E, and has effects of caring skin. The anthocyanin in the lycium ruthenicum has the effect of eliminating harmful free radicals in vivo, and the free radicals are one of important causes of aging and various diseases. And the anthocyanin can maintain and enhance the activity of the vitamin in human body, and is a synergist of the vitamin. The lycium ruthenicum anthocyanin belongs to small molecules and water-soluble substances, is easy to be quickly absorbed by a human body in an oral preparation form, can quickly enter each tissue and organ of the human body after being orally taken for 30 minutes, has good bioavailability, strong affinity to connective tissues, stability in an acidic environment, long half life, and lasting effect, and can reach 27 hours. The anthocyanin can regulate the immunity of the human body, strengthen the physique and improve the sleep: the anthocyanidin has effects of protecting cell membrane from oxidation by free radical, has strong antioxidation and antiallergic functions, can cross blood brain barrier, can protect cranial nerve from oxidation, can stabilize brain tissue function, and protect brain from damage of harmful chemical substances and toxin. The anthocyanin in the lycium ruthenicum has the effects of reinforcing blood vessels and improving circulation, can improve blood circulation, recover lost microvasculature and strengthen fragile blood vessels, so that the blood vessels are more elastic; the anthocyanins are effective in relieving pain, edema, and nocturnal spasm.

Black maca: the maca is a cruciferous plant originally produced in south America, has oval leaves and roots similar to radish, is edible, is a pure natural food, is rich in nutrient components, and the hypocotyl of the maca can be golden or light yellow, red, purple, blue, black or green. The black maca is the most abundant and rare variety in maca. The chemical components in the dry root of maca are more than 10% in protein content, 59% of carbohydrate and 8.5% of fiber, and the maca contains abundant mineral substances such as zinc, calcium, iron, titanium, rubidium, potassium, sodium, copper, manganese, magnesium, strontium, phosphorus, iodine and the like, and contains vitamin C, B₁、B₂、B₆、A、E、B₁₂、B₅Unsaturated estersThe content of fatty acid, linoleic acid and linolenic acid is more than 53%, and the natural active components comprise alkaloid, glucosinolate and its decomposition products of benzyl isothiocyanate, sterol, polyphenol, etc.

The main effects of the black maca on male body building include the following aspects: resisting fatigue: the maca contains high-content iron, protein, amino acid, mineral zinc, taurine and other components, and can obviously resist fatigue, enhance muscle endurance, resist exercise fatigue, help to strengthen immune system, improve body disease resistance, resist fatigue, enhance energy and physical strength, improve anemia symptoms, make skin color look younger and make spirit more sufficient. ② increasing the sperm quality: the nutrient substances in the natural herbaceous plants can effectively improve the number and the activity of sperms, so that the ejaculation of the male is powerful and has a longer range, and the sexual performance of the male is improved. ③ replenishing physical strength: the black maca can quickly supplement physical strength, eliminate fatigue and restore energy, and is a qualified quick physical strength enhancer passing the drug inspection. Improving impotence and premature ejaculation: rich protein amino acids, polysaccharides and mineral substances and unique bioactive substances of gamma-. Improving sleep: the black maca can effectively improve anxiety, neurasthenia and the like caused by stress, is a natural herbal medicine for eliminating anxiety, and is a good product for improving insomnia and dreaminess symptoms. Sixthly, various alkaloids of the maca can regulate adrenal gland and balance hormone level in a body, and the rich taurine, protein and the like can regulate and repair physiological functions. And seventhly, active growth: promoting sperm and ovum growth and activity, helping conception, stimulating reproductive organ, and activating sexual function. Eighthly, memory enhancement: the black maca has the effects of enabling the mind to be clear and flexible, improving the working efficiency, enabling students to progress in learning, keeping the memory of middle and old aged people, enabling the mind to be clear and having clear thinking.

Cistanche deserticola: the succulent stem of Cistanchis herba contains seven kinds of phenylethanoid glycoside components including cistanoside A, B, C, H, eugenol glycoside, 2-acetyl eugenol glycoside and echinacoside; also contains liriodendrin, 8-epinux vomica glycoside, daucosterol, betaine, beta-sitosterol, mannitol, N-dimethyl glycine methyl ester, phenylalanine, valine, leucine, isoleucine, lysine, threonine, fifteen kinds of amino acids and succinic acid; it also contains health promotion substances such as triacontanol and polysaccharides.

The pharmacological action of cistanche deserticola mainly comprises the following aspects: anti-aging, regulating endocrine, promoting metabolism and strengthening, regulating immune system and promoting DNA synthesis.

And (3) cordyceps sinensis: the cordyceps sinensis is a traditional famous and precious medicinal diet tonic in China, is neutral in nature and sweet in taste, has the functions of tonifying lung and kidney, stopping cough, tonifying deficiency and nourishing essence and qi, has the effects of nourishing lung yin, tonifying kidney yang, relieving cough, reducing phlegm, resisting cancer and preventing aging, and is a product for balancing yin and yang, which is not forbidden.

The invention preferably uses an extract of cordyceps sinensis, preferably cordycepin, more preferably 95% cordycepin. Cordycepin is a main active component (especially nucleoside) in Cordyceps and Cordyceps militaris, is a natural medicine, and has the same functions of supplementing yin and yang and regulating balance of human body. The cordycepin has purer components and better effect in the aspects of protecting liver, protecting kidney and moistening lung, and can invigorate qi and blood and eliminate the diseases such as dysmenorrheal, migraine, cervical vertebra hyperplasia and the like which can not be cured at present. From the perspective of western medicine, cordycepin has various pharmacological effects of resisting tumor, resisting aging, resisting bacteria and viruses, regulating immunity, improving metabolism, scavenging free radicals, etc.

Eucommia ulmoides: it is warm in nature, sweet and slightly pungent in flavor, and can tonify liver and kidney, strengthen tendons and bones, and is most suitable for patients with soreness and pain of waist and back, weakness of feet and knees, infantile kidney deficiency, paralysis of both lower limbs and habitual abortion caused by female kidney deficiency.

Ganoderma lucidum: sweet in flavor and warm in nature, entering heart, spleen, kidney and lung meridians. Has anticancer, liver protecting, toxic materials removing, blood sugar lowering, cardiovascular disease preventing, hyperlipidemia preventing, apoplexy preventing, antiaging, and neurasthenia relieving effects.

And (3) locking the positive: can be used for treating sexual impotence, premature ejaculation, yin deficiency, constipation, frequent micturition, hematuria, dribbling urination, soreness of waist and knees, fatigue, insomnia, amnesia, alopecia, premature gray hair, and gastric ulcer. The cynomorium songaricum can promote cell regeneration and metabolism of a human body, enhance the immunoregulation capability and has obvious effects of preventing cancer, resisting virus and delaying senility.

Lycium ruthenicum, maca, cistanche, cordyceps sinensis, eucommia ulmoides, lucid ganoderma and cynomorium songaricum belong to warm and hot medicinal materials, and the warm and hot medicinal materials are compounded and used to easily cause the symptom of excessive internal heat, so that the heat is controlled by American ginseng, lotus seeds, snow chrysanthemum and hawthorn in the formula, and the effects of soothing, soothing and nourishing and preventing and treating severe heat and dryness are achieved.

Lotus seed: neutral in nature, sweet and astringent in flavor, entering heart, spleen and kidney meridians; tonify spleen to check diarrhea, tonify kidney to astringe, nourish heart to induce tranquilization. Can be used for treating spleen deficiency, chronic diarrhea, spermatorrhea, leukorrhagia, palpitation, and insomnia. Can be used for treating dreaminess, insomnia, amnesia, vexation, thirst, lumbago, asthenia, hearing loss, spermatorrhea, stranguria with turbid urine, chronic dysentery, diarrhea, metrorrhagia, leukorrhagia, and anorexia due to stomach deficiency. The alkaloid contained in the lotus seed has the obvious cardiac function, can clear away heart fire, and has the beneficial effects of strengthening brain, enhancing memory and improving working efficiency.

Snow chrysanthemum: the coreopsis tinctoria contains various flavonoids, various mineral elements necessary for human bodies, more than 20 amino acids, dozens of aromatic compounds, abundant organic acids, vitamins, enzymes, polysaccharides and the like, and has pharmacological effects exceeding those of common scented tea. The coreopsis tinctoria has the effects of clearing away heat and toxic materials, promoting blood circulation, removing blood stasis, strengthening spleen and stomach, lowering blood pressure, reducing blood fat and blood sugar, and can also be used for treating palpitation, gastrointestinal discomfort, inappetence, dysentery and pyogenic infections. Has strong inhibitory effect on glucosidase activity, and can be used for preventing and treating diabetes. Meanwhile, the coreopsis tinctoria can also prevent the degeneration, the aging and the canceration of cells. Through research, the n-butanol extract, the petroleum ether extract and the chloroform extract of coreopsis tinctoria have the effects of regulating blood microcirculation of a human body and relaxing blood vessels, and have an obvious blood pressure reducing effect on hypertension.

Hawthorn fruit: contains vitamins, tartaric acid, citric acid, crataegolic acid, malic acid, etc., and also contains flavonoids, lactone, saccharide, protein, fat, and minerals such as calcium, phosphorus, and iron, and the lipolytic enzyme can promote digestion of fat food. Can be used for treating dyspepsia and coronary heart disease, and has effects of dilating coronary artery, increasing blood flow of coronary artery, promoting gastric secretion and increasing enzyme in stomach. The traditional Chinese medicine considers that the hawthorn has the effects of removing food stagnation, relieving stagnation, astringing, stopping dysentery, promoting blood circulation, removing blood stasis and the like, and is mainly used for treating the diseases such as food stagnation, fullness and fullness in chest and diaphragm, hernia, blood stasis, amenorrhea and the like. The hawthorn contains medicinal components such as diterpenes, flavonoids and the like, has remarkable effects of expanding blood vessels and reducing blood pressure, and has the functions of strengthening cardiac muscle, resisting arrhythmia and regulating the contents of blood fat and cholesterol.

American ginseng: american ginseng, also known as American ginseng, is a high-grade health care product which is tonic but not dry and suitable for all people, and is mainly produced in North America countries such as America, Canada and the like. It has effects in invigorating qi, nourishing blood, replenishing vital essence, invigorating kidney, invigorating spleen, nourishing stomach, delaying aging, and caring skin. American ginseng has the effects of tonifying qi and being cool in nature, does not cause excessive internal heat after being taken, and is particularly suitable for people with deficiency of both qi and yin.

Red medlar: has neutral nature and sweet taste, and has effects of invigorating kidney, nourishing liver, replenishing vital essence, improving eyesight, strengthening tendons and bones, removing lumbago, prolonging life, etc. Especially for middle-aged and elderly people with kidney deficiency, it is most suitable for eating.

Honey: the honey has the effects of caring skin, enhancing immunity, protecting liver, moistening lung, relieving fatigue, improving sleep, invigorating stomach, relaxing bowels, and promoting skin tissue regeneration, and is suitable for long-term administration by middle-aged people. The medlar nectar is brewed by collecting the medlar nectar by bees, has the traditional nutrition and health care value of the honey, and has the effects of nourishing liver and kidney, replenishing vital essence to improve eyesight, nourishing yin to strengthen yang, moistening lung to arrest cough and tonifying qi because the medlar nectar is the essence of medlar. It is suitable for people with deficiency of both blood and qi, hypertension, asthenia, visual deterioration, anemia, chronic hepatitis, toxic or metabolic liver diseases, and liver dysfunction due to biliary system. Is especially suitable for men with kidney deficiency, lumbago, spermatorrhea, and spermatorrhea.

In some preferred embodiments of the invention, the raw materials used all have unique manufacturing site requirements. The Lycium ruthenicum Murr, the black maca, the cistanche deserticola and the Lycium ruthenicum Murr are preferably produced from Qinghai Chaaida wood basins, and have the characteristics of origin of the Qinghai Lycium ruthenicum Murr, no pollution, extremely high anthocyanin content and the like. The coreopsis tinctoria is preferably produced in Xinjiang and Qinghai.

The composition provided by the invention has the following compounding principle:

taking Lycium ruthenicum Murr with effects of resisting oxidation and aging, nourishing yin and qi, moistening dryness and tranquilizing, caring skin, scavenging free radicals, regulating immunity, improving body constitution, strengthening waist and kidney, improving sleep, softening blood vessel, improving microcirculation, protecting eyes, beautifying skin, and removing black speck; the black maca has the effects of building up the body, resisting fatigue, treating male impotence and premature ejaculation, improving male sexual function and enhancing male fertility and reproductive capacity; taking cistanche to tonify kidney yang, benefit essence and blood, moisten intestinal tract and strengthen tendons and bones; and male health-care good medicines such as the red medlar, the eucommia bark, the cordyceps sinensis and the cynomorium songaricum which have the traditional functions of nourishing liver and kidney, replenishing vital essence and improving eyesight, strengthening muscles and bones and tonifying qi and blood are compatible with each other, so that the effects of delaying senility, enhancing immunity, resisting and preventing cancers, nourishing blood, tonifying liver and kidney, strengthening muscles and bones and replenishing vital essence and qi are achieved, the diseases of male impotence and premature ejaculation, yin deficiency and dragon's blood, soreness and weakness of waist and knees, fatigue and weakness, cold intolerance, limb pain, insomnia and amnesia, alopecia and early white hair and other kidney-yang deficiency symptoms are prevented and treated, and the main function of tonifying the kidney. Simultaneously, the American ginseng has the functions of tonifying qi, nourishing yin, clearing heat and promoting the secretion of saliva; ganoderma has anticancer, liver protecting, toxic materials removing, blood sugar lowering, cardiovascular disease preventing, hyperlipidemia preventing, and apoplexy preventing, and neurasthenia relieving effects; the lotus seeds are used for tonifying spleen and checking diarrhea, tonifying kidney and astringing, and nourishing heart and soothing nerves; the snow chrysanthemum is used for clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, strengthening the spleen and stomach, reducing blood pressure, blood fat and blood sugar; the hawthorn is used for removing food retention and stagnation, strengthening cardiac muscle, resisting arrhythmia, regulating the contents of blood fat and cholesterol, clearing heat and expelling toxin, and relieving depression and calming nerves. The whole formula centers on the core of tonifying the kidney, has the remarkable effects of clearing free radicals and human body toxins, resisting oxidation and aging, enhancing immunity, warming and invigorating kidney yang and enhancing male sexual function, has the effects of protecting and nourishing the liver, tonifying qi and yin, regulating emotion, conditioning endocrine, reducing blood fat, blood sugar and blood pressure, clearing heat, expelling toxin, relieving depression and soothing nerves, and can effectively prevent and treat male kidney deficiency and sub-health problems in modern workplaces. The whole formula is scientific and reasonable in collocation, the medicines (foods) are compatible together, and an innovative formula invention is formed through the change of different formulas and the sizes of ingredients.

The formula has scientific formula and accurate dosage and proportion. In the formula, sufficient lycium ruthenicum anthocyanin can remove free radicals of a human body, improve the anti-oxidation effect of the human body and enhance the immunity of the human body. And the black maca and the cistanche enter the kidney, and the red medlar, the eucommia bark, the cordycepin, the cynomorium songaricum and the like nourish the liver and kidney, replenish vital essence to improve eyesight, strengthen the muscles and the bodies and tonify qi and blood, thereby strengthening the effects of tonifying the kidney and strengthening yang. In order to prevent the whole formula from being too hot, the heat of the formula is regulated and balanced by the 'clearing', 'reducing' and 'flat' medicinal properties of the lotus seeds, the chrysanthemum and the American ginseng, so that the whole formula is flat and slightly warm, and the functions of tonifying, conditioning and cleaning are repeated, and the heat is supplemented and cleared, and the heat is mainly supplemented, so that the formula is suitable for the characteristics of the male physique of China and is suitable for long-term administration.

In an alternative embodiment, the composition for tonifying yang and invigorating kidney further comprises one or more of notoginseng, ginseng and acanthopanax; optionally, the composition comprises 5 to 15 parts by weight of notoginseng, such as but not limited to 5, 7, 10, 12 or 15 parts by weight, preferably 9 to 11 parts by weight; optionally, the composition comprises 2 to 10 parts by weight of ginseng, such as but not limited to 2, 5, 7 or 10 parts by weight, preferably 5 to 8 parts by weight; optionally, the composition comprises 5-20 parts by weight of acanthopanax senticosus, such as but not limited to 5, 8, 10, 12, 15, 18 or 20 parts by weight, preferably 9-12 parts by weight.

Wherein, the pseudo-ginseng, the ginseng and the acanthopanax have the following effects:

pseudo-ginseng: sweet, slightly bitter and warm; entering liver and stomach meridians; has effects in dispelling blood stasis, stopping bleeding, relieving swelling, and relieving pain; can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain.

Ginseng: sweet, slightly bitter and slightly warm; spleen, lung, heart and kidney meridians; has effects of invigorating primordial qi, recovering pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, nourishing blood, tranquilizing mind, and improving intelligence. Can be used for treating asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, diabetes, deficiency of both qi and blood, asthenia, palpitation, insomnia, sexual impotence, and cold womb.

Acanthopanax root: acanthopanax senticosus contains various glycosides, and some of them have similar physiological activity with ginsenoside, and have antifatigue effect, and are beneficial health beverage. Modern pharmacological research proves that acanthopanax contains various active ingredients such as eleutheroside, polysaccharide and the like, and has pharmacological effects of resisting aging, fatigue and cancer, regulating nerve, endocrine and cardiovascular functions, improving the resistance of organisms to physical, chemical, biological and other harmful stimulation and the like. Has certain curative effect in treating neurasthenia, insomnia, hypertension, coronary heart disease, cerebral infarction, cerebral arteriosclerosis, climacteric syndrome, dyslipidemia, diabetes, rheumatism, chronic bronchitis, tumor and other diseases. The radix Acanthopanacis Senticosi tea has effects of enhancing immunity, increasing blood flow, improving blood supply of heart and brain, and regulating blood pressure. It also has good therapeutic effect on sexual hypofunction, sexual impotence, premature ejaculation, etc.

The invention provides an application of the composition in preparing health products and medicines, wherein the application can be, but not limited to, resisting fatigue, resisting oxidation, tonifying yang and invigorating kidney. The composition can be used for preparing various health products or medicines for relieving sub-health of men, health products in various forms such as health wine, health oral liquid and the like, and Chinese patent medicines in various forms such as pills, paste or tablets and the like.

The invention also provides an oral liquid, the raw materials of which comprise the composition, the oral liquid has all the health care effects of the composition and also has the advantage of convenient drinking.

In some embodiments of the invention, the feedstock comprises one or more of a slurry of the feedstock, a soak of the feedstock, and an extract of the feedstock.

In some embodiments of the invention, the feedstock comprises a feedstock slurry, and in an alternative embodiment, the feedstock slurry is prepared by soaking and then juicing a dry product of each component to produce a separate feedstock slurry for each component, optionally using a juicer or juicer. In a preferred embodiment, the dry ingredients are prepared as follows to obtain a raw material slurry:

(a) crushing and soaking: slicing the dried components, crushing to 25-60 meshes, adding 5-10 times of water for soaking, wherein the black maca, the cistanche, the cynomorium songaricum and the American ginseng are preferably crushed to 40-50 meshes, and then adding 6-10 times of purified water for soaking for 5-10 hours; preferably crushing the dried lycium ruthenicum mill, the snow chrysanthemum, the eucommia ulmoides, the lotus seed and the hawthorn to 25-40 meshes, and then adding purified water with 6-10 times of volume to soak for 3-5 hours; the components are preferably soaked in purified water.

(b) Juicing: pulping the soaked components, squeezing to obtain juice, separating the juice from the residue with 80-120 mesh sieve, preferably separating the juice from the residue for 2-4 times, and completely squeezing out the effective components.

(c) Centrifugal separation: and centrifuging the slurry after residue separation at 3000-4000r/min to separate suspended slurry residue in the slurry, preferably centrifuging in a horizontal centrifuge.

(d) Degassing: degassing the separated slurry by a degasser, wherein the vacuum degree of the degasser is 0.08-0.10Mpa, and the degassing time is 2-10min, so as to remove bubbles in the slurry; then standing and clarifying for 1-2h at the temperature of 20-50 ℃.

(e) Filtering with a filter at 35-40 deg.C, refluxing the filtrate for 5-15min, and collecting clear filtrate to obtain clear slurry;

(f) sterilizing the clarified pulp by an ultrahigh temperature instant sterilizer at 95-105 deg.C for 8-15 s; placing the sterilized slurry into a temporary storage tank, rapidly cooling to 50 ℃, and concentrating;

(g) concentrating under vacuum degree of 0.08-0.12Mpa, temperature of 45-60 deg.C and steam pressure of 0.15-0.5Mpa until the soluble solid content reaches 40% -50%, and cooling to 25-35 deg.C with condensate water in condensing tank to obtain raw material slurry of each component.

Alternatively, raw material slurry of the components is prepared in advance and then is refrigerated at constant temperature of-18 to-25 ℃.

In the present embodiment, the components are soaked in, for example, but not limited to, purified water, distilled water or mineral water, or in a pharmaceutically or food acceptable solvent, and the present invention is also not limited to the addition of additives that can accelerate the foaming of the raw material drug in a dry state without damaging the drug properties.

In some embodiments of the invention, the feedstock slurry may also optionally be prepared using enzymatic or other methods that result in a slurry of the components.

In some embodiments of the invention, a raw material slurry is prepared by juicing fresh lycium ruthenicum and lycium ruthenicum fruits by the following method: selecting clean fresh lycium ruthenicum and fresh lycium ruthenicum with no mildew, no deterioration, no pesticide residue, large fruit and high maturity, preferably fresh fruits produced in 8 months from Haishi, West, Naomu Muohong area of Qinghai province, manually sorting, removing impurities, cleaning with purified water, fully pulping in a pulping machine, filtering with a 60-100 mesh filter screen, removing peel, seeds and a handle, and reserving 100% of whole juice to obtain the raw material pulp of the fresh lycium ruthenicum and the fresh lycium ruthenicum.

In some embodiments of the present invention, the raw materials comprise a soaking solution of each raw material, in some alternative embodiments, the soaking solution comprises soaking each component in a solvent which is pharmaceutically or food-art acceptable, optionally, the solvent may be, for example, but not limited to, purified water, mineral water or distilled water. In some embodiments of the invention, the feedstock may also include extracts of the components.

The invention also provides a preparation method of the oral liquid, which comprises the step of mixing the raw materials according to the formula amount, and can be, but is not limited to, the following embodiments: optionally, mixing the powder of each raw material with the raw material slurry and filtering to obtain the oral liquid, preferably crushing each raw material to 80-200 meshes, more preferably 100-120 meshes; optionally, mixing the raw material slurries of the raw materials according to the formula ratio to prepare the oral liquid; optionally, mixing the extracts of the raw materials according to the formula amount, soaking in a solvent, and filtering to obtain an oral liquid; optionally, the oral liquid is prepared by mixing the extract of the raw materials with the slurry of the raw materials according to the formula amount. The preparation method of the oral liquid provided by the invention well maintains the health care and treatment effects of the raw material medicines, is suitable for large-scale production, and has great industrial value.

In some alternative embodiments of the present invention, the oral liquid is prepared according to the following method:

(a) mixing the raw material serous fluid of lycium ruthenicum mill, maca, cistanche, eucommia ulmoides, ganoderma lucidum, cynomorium songaricum, lotus seeds, snow chrysanthemum, hawthorn, American ginseng and lycium ruthenicum mill according to the formula amount.

(b) Pulverizing Ganoderma to 100-120 mesh.

(c) Adding the ganoderma lucidum powder, the cordycepin and the honey into the raw material slurry mixed in the step (a) according to the formula amount.

(d) The flavoring is carried out using a flavoring agent, and any flavoring agent that allows consumption without affecting the function of the present invention may be selected, and citric acid and sucrose are preferred as the flavoring agent.

(e) Filtering with membrane filter under the conditions of filter membrane aperture of 2-5um and 0.15-0.5 Mpa.

(f) Sterilizing at 95-105 deg.C for 10-20s to obtain the oral liquid.

In some alternative embodiments of the present invention, the oral liquid may be prepared as follows: mixing the extracts of the above materials with Mel according to formula ratio, adding into distilled water, stirring, adding sucrose and citric acid, and flavoring. Then filtering with a membrane filter under the condition that the aperture of the filter membrane is 2-5 um; sterilizing at 95-105 deg.C for 10-20s, bottling, and sterile filling at 50 mg/bottle to obtain compound oral liquid product.

The advantageous effects of the present invention are further illustrated below with reference to preferred embodiments:

example 1

The embodiment provides a composition, which comprises the following components in parts by weight: 30 parts of black wolfberry, 10 parts of black maca, 10 parts of cistanche, 8 parts of cordyceps sinensis, 15 parts of eucommia ulmoides, 8 parts of lucid ganoderma, 10 parts of cynomorium songaricum, 8 parts of lotus seeds, 5 parts of snow chrysanthemum, 10 parts of hawthorn, 8 parts of American ginseng, 20 parts of red wolfberry, 10 parts of honey, 10 parts of pseudo-ginseng, 6 parts of ginseng and 15 parts of acanthopanax.

Example 2

The embodiment provides a composition, which comprises the following components in parts by weight: 25 parts of black medlar, 55 parts of black maca, 20 parts of cistanche, 5 parts of cordyceps sinensis, 20 parts of eucommia ulmoides, 5 parts of lucid ganoderma, 15 parts of cynomorium songaricum, 5 parts of lotus seeds, 10 parts of snow chrysanthemum, 5 parts of hawthorn, 15 parts of American ginseng, 15 parts of red medlar, 15 parts of honey and 15 parts of pseudo-ginseng.

Example 3

The embodiment provides a composition, which comprises the following components in parts by weight: 50 parts of black wolfberry, 5 parts of black maca, 5 parts of cistanche, 15 parts of cordyceps sinensis, 10 parts of eucommia ulmoides, 10 parts of lucid ganoderma, 5 parts of cynomorium songaricum, 10 parts of lotus seeds, 2 parts of snow chrysanthemum, 15 parts of hawthorn, 5 parts of American ginseng, 45 parts of red wolfberry, 5 parts of honey, 5 parts of acanthopanax and 10 parts of ginseng.

Example 4

The embodiment provides a composition, which comprises the following components in parts by weight: 25 parts of black medlar, 30 parts of black maca, 6 parts of cistanche, 15 parts of cordyceps sinensis, 6 parts of eucommia ulmoides, 18 parts of lucid ganoderma, 7 parts of cynomorium songaricum, 9 parts of lotus seeds, 3 parts of snow chrysanthemum, 12 parts of hawthorn, 12 parts of American ginseng, 15 parts of red medlar, 12 parts of honey and 2 parts of ginseng.

Example 5

The embodiment provides a composition, which comprises the following components in parts by weight: 40 parts of black medlar, 8 parts of black maca, 15 parts of cistanche, 6 parts of cordyceps sinensis, 10 parts of eucommia ulmoides, 12 parts of lucid ganoderma, 12 parts of cynomorium songaricum, 6 parts of lotus seeds, 8 parts of snow chrysanthemum, 8 parts of hawthorn, 6 parts of American ginseng, 35 parts of red medlar, 8 parts of honey, 2 parts of ginseng and 12 parts of pseudo-ginseng.

Example 6

The embodiment provides an oral liquid and a preparation method thereof, and the raw materials used in the embodiment are as follows: the raw materials except the medlar nectar all adopt the top-grade dry raw materials sold on the market, and comprise the selected dry Qinghai black medlar, plateau black maca, desert cistanche, eucommia bark, 95 percent cordycepin, lucid ganoderma, cynomorium songaricum, American ginseng, Qinghai red medlar, Xinjiang snow chrysanthemum, lotus seed, hawthorn, medlar nectar, pseudo-ginseng, ginseng and acanthopanax. Carefully sorting all the raw materials, selecting the raw materials with plant diseases and insect pests and rottenness, removing various impurities, and selecting the raw materials which are not deteriorated and are clean for later use.

The preparation method of the embodiment is as follows, and the process flow is shown in fig. 1:

(a) crushing and soaking: slicing four raw materials of black maca, cistanche, cynomorium songaricum and American ginseng, crushing the raw materials on a crusher by using a 50-mesh sieve, and then adding purified water with about 8 times of volume for soaking for about 6 hours; the black wolfberry, the red wolfberry, the Xinjiang snow chrysanthemum, the eucommia ulmoides, the lotus seed, the hawthorn, the pseudo-ginseng, the ginseng and the acanthopanax are firstly crushed on a crusher according to a 30-mesh sieve, and then 8 times of volume of purified water is respectively added for soaking for about 4 hours.

(b) Juicing: pulping the soaked components, squeezing to obtain juice, separating the juice from the residue with 100 mesh sieve, and squeezing the effective substances completely for 2 times.

(c) Centrifugal separation: and centrifuging the slurry after residue separation by using a horizontal centrifuge at 3000-4000r/min to separate suspended slurry and residue in the slurry.

(d) Degassing: degassing the separated slurry by a degasser, wherein the vacuum degree of the degasser is 0.095Mpa, and the degassing time is 5min so as to remove bubbles in the slurry; then standing and clarifying for 2h at the temperature of 40 ℃.

(e) Filtering with a filter at 35-40 deg.C, refluxing the filtrate for 10min, and collecting clear filtrate to obtain clear slurry.

(f) And (3) sterilization and cooling: sterilizing the clarified pulp by an ultrahigh-temperature instant sterilizer at 95-105 deg.C for 10 s; and (4) placing the sterilized slurry into a temporary storage tank, rapidly cooling to 50 ℃, and concentrating.

(g) Concentration: concentrating under vacuum degree of 0.096-0.099Mpa, temperature of 50-55 deg.C and steam pressure of 0.196-0.294Mpa until soluble solid reaches 45%, and cooling with condensate water in condensing tank to 30 deg.C to obtain raw material slurry of each component.

(h) Pulverizing Ganoderma with 100 mesh pulverizer.

(i) Mixing the raw material slurry of each component prepared in the above steps according to the following formula, and adding 2 times of purified water by weight: 30 parts of black wolfberry, 10 parts of black maca, 10 parts of cistanche, 15 parts of eucommia ulmoides, 8 parts of lucid ganoderma, 10 parts of cynomorium songaricum, 8 parts of lotus seed, 5 parts of snow chrysanthemum, 10 parts of hawthorn, 8 parts of American ginseng, 20 parts of red wolfberry, 10 parts of pseudo-ginseng and 15 parts of acanthopanax.

(j) Adding 8 parts of ganoderma lucidum powder, 8 parts of cordycepin and 10 parts of medlar nectar into the mixed solution, uniformly mixing, and adding citric acid and cane sugar for seasoning.

(k) Secondary filtration: filtering with membrane filter under the conditions of filter membrane aperture of 3um and 0.2 Mpa.

(l) Secondary sterilization: and finally performing high-temperature instantaneous sterilization for 10-20s at the temperature of 100 ℃.

(m) sterile filling is carried out according to the specification of 50 mL/bottle, and the oral liquid product is obtained after the detection is qualified.

Example 7

The embodiment provides an oral liquid and a preparation method thereof, and the raw materials used in the embodiment are as follows: the black wolfberry and the red wolfberry are pulped and squeezed by adopting fresh picked fruits, so that the active ingredients in the red black wolfberry are kept to the maximum extent, and the black wolfberry and the red wolfberry are selected from fresh fruits which are produced in 8 months and are selected from the carefully selected clean, moldy, metamorphic, large and high in maturity in the area of Naomao Mukoha, west of the Qinghai province; high-native product black maca, desert cistanche, eucommia ulmoides, lucid ganoderma, cynomorium songaricum, American ginseng, Xinjiang snow chrysanthemum, lotus seed, hawthorn, pseudo-ginseng, ginseng and acanthopanax senticosus are dry products.

The preparation method of this example is as follows:

(a) the raw material pulp of the lycium ruthenicum murr and the lycium ruthenicum murr is prepared by the following method: the method comprises the steps of manually sorting, removing impurities, cleaning with purified water, juicing, filtering with a 100-mesh filter screen, separating the residues of fruit seeds, fruit peels, fruit stalks and the like, and performing twice operation in the separation step to leave 100% of the whole juice, namely the raw material pulp.

(b) Pulverizing other dry materials to 60 mesh, soaking in 8 times volume of water for 24 hr, squeezing, separating the squeezed liquid from the residue with 100 mesh filter screen, and separating twice.

Steps (c) - (m) are the same as in example 6.

Example 8

The embodiment provides an oral liquid and a preparation method thereof, and the raw materials used in the embodiment are as follows: comprises the following components in parts by weight: 30 parts of 25% black wolfberry extract, 10 parts of black maca extract, 10 parts of 50% cistanche extract, 15 parts of 50% eucommia bark extract, 8 parts of 50% lucid ganoderma extract, 10 parts of 50% cynomorium songaricum extract, 8 parts of 50% American ginseng extract, 20 parts of 50% red wolfberry extract, 5 parts of 50% snow chrysanthemum extract, 8 parts of 50% lotus seed extract, 10 parts of 50% hawthorn extract, 10 parts of medlar nectar and 8 parts of 95% cordycepin. The above raw material extracts are all commercially available raw materials.

The preparation method of this example is as follows:

mixing the above raw materials, adding sterile distilled water 2 times of the total weight of the raw materials, stirring, and adding sucrose and citric acid for flavoring. Then filtering with a membrane filter under the condition that the aperture of the filter membrane is 3 um; sterilizing at 105 deg.C for 10s, and filling under sterile condition of 50 mmL/bottle. And obtaining the oral liquid product after the detection is qualified.

Comparative example 1

This comparative example provides an oral liquid and a method for preparing the same, which are different from example 6 in that, in the preparation steps (i) and (j), the raw materials are mixed in the following parts by weight: 15 parts of black medlar, 60 parts of black maca, 25 parts of cistanche, 1 part of cordyceps sinensis, 25 parts of eucommia ulmoides, 1 part of lucid ganoderma, 20 parts of cynomorium songaricum, 2 parts of lotus seeds, 15 parts of snow chrysanthemum, 2 parts of hawthorn, 20 parts of American ginseng, 10 parts of red medlar, 25 parts of honey and 20 parts of pseudo-ginseng.

Comparative example 2

This comparative example provides an oral liquid and a method for preparing the same, which are different from example 6 in that, in the preparation steps (i) and (j), the raw materials are mixed in the following parts by weight: 60 parts of black medlar, 2 parts of black maca, 2 parts of cistanche, 20 parts of cordyceps sinensis, 5 parts of eucommia ulmoides, 20 parts of lucid ganoderma, 2 parts of cynomorium songaricum, 15 parts of lotus seeds, 1 part of snow chrysanthemum, 25 parts of hawthorn, 2 parts of American ginseng, 60 parts of red medlar, 2 parts of honey, 2 parts of acanthopanax and 15 parts of ginseng.

Comparative example 3

This comparative example provides an oral liquid that differs from example 6 in that it does not contain lycium ruthenicum.

Comparative example 4

This comparative example provides an oral liquid which differs from example 6 in that no maca is present.

Comparative example 5

This comparative example provides an oral liquid, which is different from example 6 in that cistanche salsa is not contained.

Comparative example 6

The comparative example provides an oral liquid, which is different from the oral liquid in example 6 only in that the raw materials of the oral liquid only comprise lycium ruthenicum murr, maca and cistanche, and the oral liquid is a mixed liquid of raw material slurry of the lycium ruthenicum murr, the maca and the cistanche.

Comparative example 7

The comparative example provides an oral liquid, which is different from the oral liquid in example 6 only in that the raw materials of the oral liquid do not comprise lotus seeds, coreopsis tinctoria and American ginseng.

Comparative example 8

The comparative example provides an oral liquid, which is different from example 6 only in that the raw materials of the oral liquid do not include lycium barbarum, eucommia ulmoides, cordyceps sinensis and cynomorium songaricum.

The physicochemical indices of the oral liquids provided in examples 6 to 8 are as follows:

sensory index

Color: a dark brown liquid; taste and smell: sweet and slightly bitter, has unique fragrance and smell, and has no burnt or peculiar smell when diluted to the concentration of the original juice; tissue morphology: the tissue is black brown uniform liquid without layering and precipitation phenomena; impurities: no foreign matter.

2. Physical and chemical indexes

Soluble solids 35% ± 1%; the pH value is 5.0-7.0.

3. Microbiological indicator

The total number of bacteria is less than or equal to 3000/mL; coliform and pathogenic bacteria were not detected.

Effect example 1

According to a method for relieving physical fatigue function in 2003 edition of health department 'health food inspection and evaluation technical Specifications', the time for swimming with a load of a mouse and the measurement of the glycogen content of the liver are selected.

Selecting Kunming male mice, setting up test groups 1-16 and blank control groups, wherein 10 Kunming male mice are randomly selected in each group, the average weight is 19-22g, the decoction of the composition in the test groups 1-5 is 0.5mL after the decoction, the oral liquid provided by the test groups 6-8 and the comparative examples 1-8 is 0.5mL after the decoction, and the physiological saline with the same amount as the oral liquid is filled in the blank control groups. The administration is carried out 1 time daily for 30 days.

And (3) load swimming test: randomly taking 5 mice in each group, loading the tail of the mouse with 5 percent of weight, putting the mouse in a pool of 40cm multiplied by 60cm multiplied by 40cm for swimming, and recording the time from the beginning of swimming to death of the mouse as the time for loading and swimming of the mouse, wherein the water depth is 30 cm.

Liver glycogen assay: and (3) killing the mice by using a cervical dislocation method for the rest mice in each group, taking the liver, homogenizing, and measuring the content of hepatic glycogen by using an anthrone method. The results are shown in the following table:

as can be seen from the above table: the component formula of the composition with the effects of tonifying yang and invigorating kidney provided by the invention can improve the average swimming time and the average glycogen amount of a mouse, so that the composition has a good anti-fatigue effect, and as can be seen from the examples and comparative examples 3-8, the formula provided by the invention is reasonable in compatibility, and the components of the composition have synergistic effect; from examples 6-8, it can be seen that the composition can be made into oral liquid to help the body absorb the drug effect; as can be seen from example 6 and comparative examples 1-2, the formula amounts provided by the present invention provide the best anti-fatigue effect.

Effect example 2

Randomly selecting 100 middle-aged male volunteers of 25-45, providing the oral liquid in the embodiment 6 of the invention for the volunteers, 1 time every day, 50mL each time, and revisiting the use effect after one month, wherein 82 volunteers clearly show that the fatigue is relieved and the energy is vigorous after the oral liquid is used; libido was enhanced and sexual function was significantly improved, with typical cases as follows:

typical case 1

Wangzhi, male, age 40, a small enterprise is high in management, working pressure is high, obesity is caused due to long-term remuneration and irregular diet, people often feel poor physical strength and fatigue before drinking the oral liquid, people are unable to do amateur life after working every day, and slight depression and insomnia, irritability and irritability are caused due to high working pressure, and people live 1 time per month or asexual life. After the oral liquid is taken, the energy is sufficient, the physical exercise is carried out in non-working time, the sub-health state of Wangzhi is further relieved, the sleep quality is improved, the libido is enhanced, and the sexual capacity is also improved.

Typical case 2

Von Zeng, male, 28 years old, company staff, the pressure of work is great, even though people do not drink the oral liquid of the invention and do not have physical exercise, they often feel weak, sweat easily appears in the process of exercise, and the sexual ability is not good. After the oral liquid is taken for one week, the energy is full, the sweating of deficiency is not caused, although the living pressure is not reduced, the mental state of depression and falling is not easy to appear compared with the mental state before the oral liquid is taken, the sexual capability is obviously improved, and the sexual life time is improved by more than 50 percent.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (27)

1. The composition for tonifying yang and invigorating kidney is characterized by comprising the following components in parts by weight: 25-250 parts of black wolfberry, 5-55 parts of black maca, 5-20 parts of cistanche, 5-15 parts of cordyceps sinensis, 10-20 parts of eucommia ulmoides, 5-10 parts of lucid ganoderma, 5-15 parts of cynomorium songaricum, 5-10 parts of lotus seeds, 2-10 parts of coreopsis tinctoria, 5-15 parts of hawthorn, 5-15 parts of American ginseng, 15-120 parts of red wolfberry, 5-15 parts of honey, 5-15 parts of pseudo-ginseng, 2-10 parts of ginseng and 5-20 parts of acanthopanax.

2. The composition of claim 1, wherein the lycium ruthenicum is a dried lycium ruthenicum or a fresh lycium ruthenicum; the red wolfberry is dry red wolfberry or fresh red wolfberry.

3. The composition of claim 2, wherein the composition comprises 25 to 50 parts by weight of dried lycium ruthenicum.

4. The composition according to claim 3, wherein the composition comprises 25 to 40 parts by weight of dried Lycium ruthenicum Murr.

5. The composition according to claim 4, wherein the composition comprises 25 to 35 parts by weight of dried Lycium ruthenicum Murr.

6. The composition of claim 2, wherein the fresh lycium ruthenicum murr is present in the composition in an amount of 50 to 200 parts by weight.

7. The composition as claimed in claim 6, wherein the composition comprises 100 parts by weight of fresh Lycium ruthenicum Murr.

8. The composition as claimed in claim 7, wherein the composition comprises 150 parts by weight of Lycium ruthenicum fresh product.

9. The composition of claim 2, wherein the dried lycium ruthenicum is present in an amount of 15 to 45 parts by weight.

10. The composition of claim 9, wherein the dried lycium ruthenicum is present in an amount of 15 to 35 parts by weight.

11. The composition of claim 10, wherein the composition comprises 18 to 25 parts by weight of dried lycium ruthenicum.

12. The composition of claim 2, wherein the fresh lycium ruthenicum murr is present in the composition in an amount of 45 to 75 parts by weight.

13. The composition of claim 12, wherein the fresh lycium ruthenicum murr is present in the composition in an amount of 50 to 65 parts by weight.

14. The composition of claim 13, wherein the fresh lycium ruthenicum murr is present in an amount of 55 to 65 parts by weight.

15. The composition as claimed in claim 1, wherein the notoginseng radix is 8-12 weight parts.

16. The composition of claim 15, wherein the notoginseng radix is 9 to 11 parts by weight.

17. The composition as claimed in claim 1, wherein the ginseng is 4-9 parts by weight.

18. The composition as claimed in claim 17, wherein the ginseng is 5-8 parts by weight.

19. The composition of claim 1, wherein the acanthopanax senticosus is 8-15 parts by weight.

20. The composition of claim 19, wherein the acanthopanax senticosus is 9-12 parts by weight.

21. The composition of claim 1, wherein the honey is wolfberry nectar.

22. Use of a composition according to any one of claims 1 to 21 for the preparation of a health product and a medicament for the anti-fatigue and yang-and kidney-strengthening.

23. An oral liquid, wherein a raw material of the oral liquid comprises the composition according to any one of claims 1 to 21.

24. The oral liquid of claim 23, wherein the raw material is one or more of a slurry of the raw material, a soaking solution of the raw material, and an extract of the raw material.

25. A method of preparing the oral liquid of claim 23 or 24, comprising the step of mixing the raw materials in a prescribed amount.

26. The method of claim 25, comprising the steps of:

(a) pulverizing maca, herba cistanches, herba Cynomorii, radix Panacis Quinquefolii, fructus Lycii, coreopsis tinctoria, cortex Eucommiae, semen Nelumbinis, fructus crataegi, radix Ginseng, radix Notoginseng, and radix Et caulis Acanthopanacis Senticosi respectively, soaking, and squeezing to obtain juice;

(b) crushing the ganoderma lucidum to 100-one 120 meshes;

(c) mixing the components in the step (a) and the step (b), honey and the cordyceps sinensis extract according to the formula amount, filtering and sterilizing.

27. The method of claim 26, wherein step (a) further comprises the steps of: crushing and soaking the components, pulping, juicing, and sequentially performing centrifugal separation, degassing, filtering, sterilizing and vacuum concentration on the juice obtained after juicing to obtain the raw material pulp of each component.

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