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CN106977494A - Substituted pyrazolecarboxylic amides compound and its application - Google Patents

Substituted pyrazolecarboxylic amides compound and its application Download PDF

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Publication number
CN106977494A
CN106977494A CN201610028679.4A CN201610028679A CN106977494A CN 106977494 A CN106977494 A CN 106977494A CN 201610028679 A CN201610028679 A CN 201610028679A CN 106977494 A CN106977494 A CN 106977494A
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alkyl
halo
alkoxy
carbonyl
substituted
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CN106977494B (en
Inventor
张来俊
葛家成
葛尧伦
刘羽
王心怡
白复芹
司国栋
刘晓晨
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Hailir Pesticides and Chemicals Group Co Ltd
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Hailir Pesticides and Chemicals Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention discloses a kind of substituted pyrazolecarboxylic amides compound and its N- oxides, salt and composition, structure is as shown in formula I, and each substituent is defined in the specification in formula.The substituted pyrazolecarboxylic amides compound of the present invention has broad-spectrum insecticidal activity, and good prevention effect is obtained with very low dosage to aphid, striped rice borer, diamondback moth, beet armyworm etc..

Description

Substituted pyrazolecarboxylic amides compound and its application
Technical field
The invention belongs to desinsection field, more particularly to a kind of substituted pyrazolecarboxylic amides compound and N- oxides, salt and Composition, and use they agricultural or other field in as insecticide application.
Background technology
O-formammidotiazol-benzamide compounds (ryanodine receptor inhibitor class) are the preventing and treating squama wings developed in recent years Effective insecticide of mesh insect.
The following compound with insecticidal activity is disclosed in patent WO 03015519：
The following compound with insecticidal activity is disclosed in patent WO 2004067528：
Above patent (application) though in all disclosed compounds have similarity with the compounds of this invention, structure is still deposited Significant different.
The content of the invention
The substituted pyrazolecarboxylic of a variety of pest and disease damages can be just controlled under the dosage of very little it is an object of the invention to provide a kind of Amides compound and its N- oxides or its salt, it can be applied to the controlling invertebrate in agronomy and non-agronomic environments and does harm to Worm.
Technical scheme is as follows：
The present invention provides a kind of substituted pyrazolecarboxylic amides compound, as shown in formula I：
In formula：
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2、NH2、NHCH3、C1-C6Alkyl, Halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkenyl, Halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
X is selected from H, halogen, CN, NO2、NH2, CHO, CH=NOCH3, CH=NNHCH3, CH=NN (CH3)2、C1-C6Alkyl, Halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkenyl, Halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
Z is selected from N or CRb；Rb=H, halogen or NO2；
R1Selected from halogen, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、C1-C6Alkyl, halo C1-C6 Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, oxa- C2-C8Cycloalkyl, azepine C2-C8Cycloalkyl, thia C2-C8Cycloalkanes Base, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl C1-C6Alkyl, halo C1-C6Alkyl sulfinyl C1-C6Alkyl, C1-C6Alcoxyl sulfinyl C1-C6Alkyl, halo C1-C6Alcoxyl sulfinyl C1-C6Alkane Base, C1-C6Alkane sulfonyl C1-C6Alkyl, halo C1-C6Alkane sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfonyl C1-C6Alkyl, halogen For C1-C6Alcoxyl sulfonyl C1-C6Alkyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogen For C1-C6Alkyl, sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6 Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, halo C1-C6Alkoxy Halo C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkane Base, halo C1-C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1- C6Alkylamino radical halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkane Epoxide carbonyl, C1-C6Alkylthiocarbonyl, halo C1-C6Alkylthiocarbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylamino radical carbonyl Base, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6 Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkanamine Base carbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkylthiocarbonyl C1-C6Alkyl, halo C1-C6Alkane Sulfenyl carbonyl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, Substituted or unsubstituted aryloxy group C1-C6Alkyl, substituted or unsubstituted aryloxy group halo C1-C6It is alkyl, substituted or unsubstituted Aryl amine C1-C6Alkyl, substituted or unsubstituted aryl amine halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkane Base, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6Alkyl, substitution or not Substituted heteroaryloxy halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amido C1-C6Alkyl, substituted or unsubstituted heteroaryl Amido halo C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl halo C1- C6Alkyl, substituted or unsubstituted aryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted aryloxycarbonyl halo C1-C6Alkyl, Substituted or unsubstituted aryl amine carbonyl C1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl halides are for C1-C6Alkyl, substitution or Unsubstituted Heteroarylcarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroarylcarbonyl halo C1-C6Alkyl, substitution or unsubstituted Heteroaryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroaryloxycarbonyl halo C1-C6It is alkyl, substituted or unsubstituted Heteroaryl amino-carbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl amino-carbonyl halo C1-C6Alkyl, substituted or unsubstituted virtue Base carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted aryl amine carbonyl, substituted or unsubstituted aryl amine It is thiocarbonyl, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted Heteroaryloxycarbonyl, substituted or unsubstituted miscellaneous Aryl amine carbonyl, substituted or unsubstituted heteroaryl amido thiocarbonyl, substituted or unsubstituted aryl C1-C6Alkoxy C1-C6Alkane Base, substituted or unsubstituted heteroaryl C1-C6Alkoxy C1-C6Alkyl；
R2,R3It may be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkane Base, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, two (C1-C6Alkyl) amido, C1- C6Alkyl (halo C1-C6Alkyl) amido, C1-C6Alkyl-carbonyl amido, halo C1-C6Alkyl-carbonyl amido, C1-C6Alkoxy carbonyl Base amido, halo C1-C6Alkoxycarbonylamino, C1-C6Alkyl sulphinyl amido, halo C1-C6Alkyl sulphinyl amido, C1-C6Alkyl sulphonyl amido, halo C1-C6Alkyl sulphonyl amido, C1-C6Alkyl-carbonyl (C1-C6Alkyl) amido, halo C1- C6Alkyl-carbonyl (C1-C6Alkyl) amido, C1-C6Alkoxy carbonyl (C1-C6Alkyl) amido, halo C1-C6Alkoxy carbonyl (C1- C6Alkyl) amido, C1-C6Alkyl sulphinyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphinyl (C1-C6Alkyl) amine Base, C1-C6Alkyl sulphonyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphonyl (C1-C6Alkyl) amido, C1-C6Alkane sulphur Base, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane Sulfonyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6 Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1- C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6 Alkyl-carbonyl C1-C6Alkoxy, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkane Epoxide carbonyl C1-C6Alkoxy, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy, ammonia unsubstituted or by following substituent group Base C1-C6Alkyl, aryl, aryloxy group, aryl C1-C6Alkyl, aryl C1-C6Alkoxy, heteroaryl, heteroaryl C1-C6It is alkyl, miscellaneous Aryl C1-C6Alkoxy：Halogen, cyano group, nitro, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1-C6Alcoxyl Base, C1-C6Alkylthio group or C1-C6Alkyl-carbonyl；
R4Selected from H, halogen, CN, CONH2、CSNH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8 Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C2-C6Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano group halogen For C1-C6Alkyl, cyano group C1-C6Alkoxy, cyano halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkane Epoxide C1-C6Alkyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl amido, halogen For C1-C6Alkyl sulfinyl amido, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6 Alkyl, C1-C6Alkyl sulfinyl amido C1-C6Alkyl, halo C1-C6Alkyl sulfinyl amido C1-C6Alkyl, C1-C6Alkane sulfonyl Epoxide, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl amido, halo C1-C6Alkane sulfonyl amido, C1-C6Alkane sulfonyl Epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl amido C1-C6Alkyl, halo C1-C6 Alkane sulfonyl amido C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6 Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy carbonyl C1-C6Alkoxy, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy, C1-C6Alkylaminocarbonyl C1-C6Alkoxy, halo C1-C6Alkylaminocarbonyl C1-C6Alkane Epoxide, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkane Base, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkane Base, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkoxy, substituted or unsubstituted aryl C1-C6 Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxy, substitution do not take The aryl halide in generation is for C1-C6Alkoxy, substituted or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxy, substituted or unsubstituted heteroaryl halo C1-C6Alkoxy；
R5,R6It may be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Ring Alkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, Halo C1-C6Alkoxy, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, Halo C1-C6Alkoxy carbonyl, C1-C6Alkyl amino, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6Alkyl amino Carbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkoxy, halo C1- C6Alkoxy C1-C6Alkoxy, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkane Epoxide carbonyl C1-C6Alkoxy, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1- C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkoxy；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Alkenyl, C2-C6Alkynyl, each of which optionally by one or Multiple following substituent substitutions：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1- C6Alkoxy, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane Sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 First hetero-aromatic ring；Phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan of hetero-aromatic rings each optionally independent are taken by 1 to 3 selected from following For base substitution：C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6 Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, halogen, CN, NO2、C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl ammonia Base, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6(alkyl) (cycloalkyl) amino, C1-C6Alkyl-carbonyl, C1-C6Alkane Epoxide carbonyl, C1-C6Alkyl amino-carbonyl, C2-C8Dialkyl amino carbonyl；C1-C6Alkoxy；C1-C6Alkyl amino；C2-C6Two Alkyl amino；C3-C8Cycloalkyl amino；C1-C6Alkyl-carbonyl or C1-C6Alkoxy carbonyl；
R8Selected from H, OH, NH2、C(CH3)2CH2S(O)(NH)CH3、C(CH3)2CH2S(O)(NCN)CH3、C1-C6Alkyl, halogen For C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2- C6Alkynyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, C3-C8Oxacycloalkyl, C3-C8Oxacycloalkyl C1-C6 Alkyl, hydroxyl C1-C6Alkyl, C1-C6Alkyl amine group C1-C6Alkyl, two (C1-C6Alkyl) amido C1-C6Alkyl, substitution do not take The pyridine radicals C in generation1-C6Alkyl, substituted or unsubstituted thiazolyl C1-C6Alkyl, substituted or unsubstituted pyridine epoxide C1-C6Alkane Base, substituted or unsubstituted pyridine thio C1-C6Alkyl, substituted or unsubstituted pyridine amido C1-C6Alkyl, substitution do not take The morpholine base in generation, substitution or or unsubstituted piperazinyl, morpholine base C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6 Alkyl sulfoxide base C1-C6Alkyl, C1-C6Alkyl sulfuryl C1-C6Alkyl, C1-C6Alkyl carbonyl epoxide, C1-C6Alkoxy carbonyl oxygen Base, C1-C6Alkylaminocarbonyl epoxide, C1-C6Alkyl sulphonyl epoxide, halo C1-C6Alkyl sulphonyl epoxide, C1-C6Alkyl sulfonyl Amido, halo C1-C6Alkylsulfonamido, substituted or unsubstituted aryl carbonyl epoxide, substituted or unsubstituted aryloxycarbonyl It is epoxide, substituted or unsubstituted aryl amine carbonyl epoxide, substituted or unsubstituted Heteroarylcarbonyl epoxide, substituted or unsubstituted Heteroaryloxycarbonyl epoxide, substituted or unsubstituted heteroaryl amino-carbonyl epoxide, C1-C6Alkylamino radical thiocarbonyl epoxide, substitution or Unsubstituted aryl amine thiocarbonyl epoxide, substituted or unsubstituted aryl C1-C6Alkoxy, substituted or unsubstituted pyridine radicals C1-C6Alkoxy, substituted or unsubstituted thiazolyl C1-C6Alkoxy, C1-C6Alkyl-carbonyl amido, C1-C6Alkoxy carbonyl amine Base, C1-C6Alkylaminocarbonyl amido, C1-C6Alkylamino radical thiocarbonyl amido, substituted or unsubstituted aryl carbonyl amido, substitution Or unsubstituted aryloxycarbonyl amido, substituted or unsubstituted aryl amine carbonylamino, substituted or unsubstituted aryl amine sulphur For carbonylamino, substituted or unsubstituted Heteroarylcarbonyl amido, substituted or unsubstituted Heteroaryloxycarbonyl amido, substitution or Unsubstituted heteroaryl amino-carbonyl amido, substituted or unsubstituted heteroaryl amido thiocarbonyl amido, amino carbonyl amido, C1-C6 Alkylamino radical, two (C1-C6) alkylamino radical, substituted or unsubstituted aryl C1-C6Alkylamino radical, substituted or unsubstituted pyridine radicals C1-C6 Alkylamino radical, substituted or unsubstituted thiazolyl C1-C6Alkylamino radical, N (t-Bu) (COPh), N=CHN (CH3)2, N=C (CH3)2、N =CHCF3, N=CHPh, N=CH (2-Py), N=CH (3-Py), N=CH (4-Py)；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxy, Halo C1-C6Alkoxy, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halogen For C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkane Amino-carbonyl, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6 Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl, substitution or Unsubstituted aryloxycarbonyl, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted Heteroaryloxycarbonyl, substitution or Unsubstituted aryl amine carbonyl, substituted or unsubstituted aryl amine thiocarbonyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkane is sub- Sulfonyl, C1-C6Alcoxyl sulfinyl, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, halo C1-C6Alcoxyl sulfonyl；
The present invention more preferred compound is：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2、NH2Or NHCH3；
X is selected from H, halogen, CN, NO2、NH2, CHO, CH=NOCH3, CH=NNHCH3Or CH=NN (CH3)2；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from halogen, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、C1-C6Alkyl, halo C1-C6 Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, oxa- C2-C8Cycloalkyl, azepine C2-C8Cycloalkyl, thia C2-C8Cycloalkanes Base, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl C1-C6Alkyl, halo C1-C6Alkyl sulfinyl C1-C6Alkyl, C1-C6Alcoxyl sulfinyl C1-C6Alkyl, halo C1-C6Alcoxyl sulfinyl C1-C6Alkane Base, C1-C6Alkane sulfonyl C1-C6Alkyl, halo C1-C6Alkane sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfonyl C1-C6Alkyl, halogen For C1-C6Alcoxyl sulfonyl C1-C6Alkyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogen For C1-C6Alkyl, sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6 Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, halo C1-C6Alkoxy Halo C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkane Base, halo C1-C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1- C6Alkylamino radical halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkane Epoxide carbonyl, C1-C6Alkylthiocarbonyl, halo C1-C6Alkylthiocarbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylamino radical carbonyl Base, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6 Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkanamine Base carbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkylthiocarbonyl C1-C6Alkyl, halo C1-C6Alkane Sulfenyl carbonyl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, Substituted or unsubstituted aryloxy group C1-C6Alkyl, substituted or unsubstituted aryloxy group halo C1-C6It is alkyl, substituted or unsubstituted Aryl amine C1-C6Alkyl, substituted or unsubstituted aryl amine halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkane Base, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6Alkyl, substitution or not Substituted heteroaryloxy halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amido C1-C6Alkyl, substituted or unsubstituted heteroaryl Amido halo C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl halo C1- C6Alkyl, substituted or unsubstituted aryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted aryloxycarbonyl halo C1-C6Alkyl, Substituted or unsubstituted aryl amine carbonyl C1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl halides are for C1-C6Alkyl, substitution or Unsubstituted Heteroarylcarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroarylcarbonyl halo C1-C6Alkyl, substitution or unsubstituted Heteroaryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroaryloxycarbonyl halo C1-C6It is alkyl, substituted or unsubstituted Heteroaryl amino-carbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl amino-carbonyl halo C1-C6Alkyl, substituted or unsubstituted virtue Base C1-C6Alkoxy C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxy C1-C6Alkyl；
R2,R3It may be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkane Base, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, two (C1-C6Alkyl) amido, C1- C6Alkyl-carbonyl amido, halo C1-C6Alkyl-carbonyl amido, C1-C6Alkoxycarbonylamino, C1-C6Alkyl sulphinyl amido, Halo C1-C6Alkyl sulphinyl amido, C1-C6Alkyl sulphonyl amido, halo C1-C6Alkyl sulphonyl amido, C1-C6Alkyl Carbonyl (C1-C6Alkyl) amido, halo C1-C6Alkyl-carbonyl (C1-C6Alkyl) amido, C1-C6Alkoxy carbonyl (C1-C6Alkyl) Amido, C1-C6Alkyl sulphinyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphinyl (C1-C6Alkyl) amido, C1-C6 Alkyl sulphonyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphonyl (C1-C6Alkyl) amido, C1-C6Alkylthio group, halo C1- C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1- C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylamino radical carbonyl Base, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkyl oxycarbonyl Base C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkoxy, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkoxy, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy；
R4Selected from H, halogen, CN, CONH2、CSNH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8 Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C2-C6Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano group halogen For C1-C6Alkyl, cyano group C1-C6Alkoxy, cyano halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkane Epoxide C1-C6Alkyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl amido, halogen For C1-C6Alkyl sulfinyl amido, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6 Alkyl, C1-C6Alkyl sulfinyl amido C1-C6Alkyl, halo C1-C6Alkyl sulfinyl amido C1-C6Alkyl, C1-C6Alkane sulfonyl Epoxide, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl amido, halo C1-C6Alkane sulfonyl amido, C1-C6Alkane sulfonyl Epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl amido C1-C6Alkyl, halo C1-C6 Alkane sulfonyl amido C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6 Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy carbonyl C1-C6Alkoxy, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy, C1-C6Alkylaminocarbonyl C1-C6Alkoxy, halo C1-C6Alkylaminocarbonyl C1-C6Alkane Epoxide, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkane Base, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkane Base, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkoxy, substituted or unsubstituted aryl C1-C6 Alkyl, substituted or unsubstituted aryl C1-C6Alkoxy, substituted or unsubstituted heteroaryl C1-C6Alkyl, substitution or unsubstituted Heteroaryl C1-C6Alkoxy；
R5,R6It may be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Ring Alkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, Halo C1-C6Alkoxy, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulphur Acyl group, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkane Base amino, C2-C6Dialkyl amido, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkoxy, halo C1-C6Alkoxy C1-C6Alkoxy, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl Base C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkoxy, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy, C1-C6Alkyl oxycarbonyl Base C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkoxy；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Alkenyl, C2-C6Alkynyl, each of which optionally by one or Multiple following substituent substitutions：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1- C6Alkoxy, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane Sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 First hetero-aromatic ring；Phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan of hetero-aromatic rings each optionally independent are taken by 1 to 3 selected from following For base substitution：C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6 Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, halogen, CN, NO2、C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl ammonia Base, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6(alkyl) (cycloalkyl) amino, C1-C6Alkyl-carbonyl, C1-C6Alkane Epoxide carbonyl, C1-C6Alkyl amino-carbonyl, C2-C8Dialkyl amino carbonyl；
R8Selected from H, OH, NH2、C(CH3)2CH2S(O)(NH)CH3、C(CH3)2CH2S(O)(NCN)CH3、C1-C6Alkyl, halogen For C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2- C6Alkynyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, C3-C8 Oxacycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, hydroxyl C1-C6Alkyl, C1-C6Alkyl amine group C1-C6Alkane Base, two (C1-C6Alkyl) amido C1-C6Alkyl, substituted or unsubstituted pyridine radicals C1-C6Alkyl, substituted or unsubstituted thiazole Base C1-C6Alkyl, substituted or unsubstituted pyridine epoxide C1-C6Alkyl, substituted or unsubstituted pyridine thio C1-C6Alkyl, take Generation or unsubstituted pyridine amido C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl sulfoxide base C1-C6Alkyl, C1-C6 Alkyl sulfuryl C1-C6Alkyl, C1-C6Alkyl carbonyl epoxide, C1-C6Alkoxy-carbonyl oxy, C1-C6Alkylaminocarbonyl epoxide, C1- C6Alkyl sulphonyl epoxide, halo C1-C6Alkyl sulphonyl epoxide, C1-C6Alkylsulfonamido, halo C1-C6Alkyl sulfonamide Base, substituted or unsubstituted aryl carbonyl epoxide, substituted or unsubstituted aryloxycarbonyl epoxide, substituted or unsubstituted heteroaryl Base carbonyl epoxide, substituted or unsubstituted Heteroaryloxycarbonyl epoxide, C1-C6Alkylamino radical thiocarbonyl epoxide, substitution or unsubstituted Aryl amine thiocarbonyl epoxide, substituted or unsubstituted aryl C1-C6Alkoxy, substituted or unsubstituted pyridine radicals C1-C6Alkane Epoxide, substituted or unsubstituted thiazolyl C1-C6Alkoxy, C1-C6Alkyl-carbonyl amido, C1-C6Alkoxycarbonylamino, C1-C6 Alkylaminocarbonyl amido, C1-C6Alkylamino radical thiocarbonyl amido, substituted or unsubstituted aryl carbonyl amido, substitution or unsubstituted Aryloxycarbonyl amido, substituted or unsubstituted aryl amine carbonylamino, substituted or unsubstituted aryl amine thiocarbonyl amine Base, amino carbonyl amido, C1-C6Alkylamino radical, two (C1-C6) alkylamino radical, substituted or unsubstituted aryl C1-C6Alkylamino radical, substitution Or unsubstituted pyridine radicals C1-C6Alkylamino radical, substituted or unsubstituted thiazolyl C1-C6Alkylamino radical；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halogen For C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl Base, halo C1-C6Alkoxy carbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkane Epoxide carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl, substitution or not Substituted aryloxycarbonyl, substituted or unsubstituted Heteroarylcarbonyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl；
Less preferred compound is the present invention again：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2；
X is selected from H, halogen, CN, NO2、NH2Or CHO；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from halogen, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、C1-C6Alkyl, halo C1-C6 Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, oxa- C2-C8Cycloalkyl, azepine C2-C8Cycloalkyl, thia C2-C8Cycloalkanes Base, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl C1-C6Alkyl, halo C1-C6Alkyl sulfinyl C1-C6Alkyl, C1-C6Alcoxyl sulfinyl C1-C6Alkyl, halo C1-C6Alcoxyl sulfinyl C1-C6Alkane Base, C1-C6Alkane sulfonyl C1-C6Alkyl, halo C1-C6Alkane sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfonyl C1-C6Alkyl, halogen For C1-C6Alcoxyl sulfonyl C1-C6Alkyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogen For C1-C6Alkyl, sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6 Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, halo C1-C6Alkoxy Halo C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkane Base, halo C1-C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1- C6Alkylamino radical halo C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alcoxyl Base carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkane Amino-carbonyl C1-C6Alkyl, C1-C6Alkylthiocarbonyl C1-C6Alkyl, halo C1-C6Alkylthiocarbonyl C1-C6Alkyl, substitution or not Substituted aryl C1-C6Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, substituted or unsubstituted aryloxy group C1-C6Alkane Base, substituted or unsubstituted aryloxy group halo C1-C6Alkyl, substituted or unsubstituted aryl amine C1-C6Alkyl, substitution do not take The aryl amine halo C in generation1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6Alkyl, substituted or unsubstituted heteroaryloxy halo C1-C6Alkyl, Substituted or unsubstituted heteroaryl amido C1-C6Alkyl, substituted or unsubstituted heteroaryl amido halo C1-C6Alkyl, substitution do not take The aryl C in generation1-C6Alkoxy C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxy C1-C6Alkyl；
R2,R3It may be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkane Base, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, two (C1-C6Alkyl) amido, C1- C6Alkyl-carbonyl amido, halo C1-C6Alkyl-carbonyl amido, C1-C6Alkoxycarbonylamino, C1-C6Alkyl sulphinyl amido, Halo C1-C6Alkyl sulphinyl amido, C1-C6Alkyl sulphonyl amido, halo C1-C6Alkyl sulphonyl amido, halo C1-C6 Alkyl-carbonyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphinyl (C1-C6Alkyl) amido, C1-C6Alkyl sulphonyl (C1- C6Alkyl) amido, halo C1-C6Alkyl sulphonyl (C1-C6Alkyl) amido, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6 Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, halogen For C1-C6Alkyl-carbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl；
R4Selected from H, halogen, CN, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6 Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano halo C1-C6Alkane Base, cyano group C1-C6Alkoxy, cyano halo C1-C6Alkoxy, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl oxygen Base, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl oxygen Base, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkane Base, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, substitution or not Substituted heteroaryl C1-C6Alkyl；
R5,R6It may be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Ring Alkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, Halo C1-C6Alkoxy, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulphur Acyl group, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Alkenyl, C2-C6Alkynyl, each of which optionally by one or Multiple following substituent substitutions：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1- C6Alkoxy, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane Sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 First hetero-aromatic ring；
R8Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halogen For C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkane Base, C1-C6Alkylthio group C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, hydroxyl C1-C6Alkane Base, two (C1-C6Alkyl) amido C1-C6Alkyl, C3-C8Oxacycloalkyl C1-C6Alkyl, substituted or unsubstituted pyridine radicals C1-C6 Alkyl, substituted or unsubstituted thiazolyl C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl sulfoxide base C1-C6Alkane Base, C1-C6Alkyl sulfuryl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxy, substituted or unsubstituted pyridine radicals C1- C6Alkoxy, substituted or unsubstituted thiazolyl C1-C6Alkoxy；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alcoxyl Base carbonyl, halo C1-C6Alkoxy carbonyl, the substituted or unsubstituted Heteroarylcarbonyl of substituted or unsubstituted aryl carbonyl, C1- C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl；
The further preferred compound of the present invention is：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H or CN；
X is selected from H, halogen or CN；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from halogen, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、C1-C6Alkyl, halo C1-C6 Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, oxa- C2-C8Cycloalkyl, azepine C2-C8Cycloalkyl, thia C2-C8Cycloalkanes Base, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl C1-C6Alkyl, halo C1-C6Alkyl sulfinyl C1-C6Alkyl, C1-C6Alcoxyl sulfinyl C1-C6Alkyl, halo C1-C6Alcoxyl sulfinyl C1-C6Alkane Base, C1-C6Alkane sulfonyl C1-C6Alkyl, halo C1-C6Alkane sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfonyl C1-C6Alkyl, halogen For C1-C6Alcoxyl sulfonyl C1-C6Alkyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogen For C1-C6Alkyl, sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6 Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, halo C1-C6Alkoxy Halo C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkane Base, halo C1-C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1- C6Alkylamino radical halo C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkane Base, substituted or unsubstituted aryloxy group C1-C6Alkyl, substituted or unsubstituted aryloxy group halo C1-C6Alkyl, substitution do not take The aryl amine C in generation1-C6Alkyl, substituted or unsubstituted aryl amine halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6 Alkyl, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6Alkyl, substitution or Unsubstituted heteroaryloxy halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amido C1-C6It is alkyl, substituted or unsubstituted miscellaneous Aryl amine halo C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxy C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxy C1-C6Alkyl；
R2,R3It may be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkane Base, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkylthio group, halo C1-C6Alkylthio group, two (C1-C6Alkyl) amido, C1-C6Alkyl-carbonyl amido, halo C1-C6Alkyl oxycarbonyl Base amido, C1-C6Alkoxycarbonylamino, C1-C6Alkyl sulphinyl amido, halo C1-C6Alkyl sulphinyl amido, C1-C6 Alkyl sulphonyl amido, halo C1-C6Alkyl sulphonyl amido；
R4Selected from H, halogen, CN, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, cyano group C1-C6Alkyl, cyano group C1-C6Alkoxy, cyano halo C1-C6Alkoxy, C1-C6Alkane sulfonyl epoxide, halo C1-C6Alkane sulphonyl Base epoxide, C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkoxy carbonyl Base, substituted or unsubstituted heteroaryl C1-C6Alkyl；
R5,R6It may be the same or different, be respectively selected from H, halogen, CN, CF3Or NO2；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Alkenyl, C2-C6Alkynyl；
R8Selected from H,C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C3-C8Cycloalkyl, C (CH3)2CH2SCH3、CH2CH2CH2N(CH3)2、CH(CH3)CH2OH、
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alcoxyl Base carbonyl or halo C1-C6Alkoxy carbonyl；
Present invention compound still further preferably is：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NH；
X is selected from H, F, Cl, Br, I, CN；
Z is selected from N or CRd；Rd=H, F, Cl, Br；
R1Selected from F, Cl, Br, I, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、CH3、CH2CH3、CH (CH3)2、CF3、CF2H、CF2CF2H、CH2CF3、CF2CF3, cyclopropyl,CH=CH2、CH2- CH=CH2、 CH2CH=CHCl, C ≡ CH, CH2-C≡CH、CH2C≡CI、CH2S(O)CH3、CH2S(O)CF3、CH2S(O)2CH3、CH2S(O)2CF3、 CH2CN、CH2CH2CN、CH2OCH3、CH2CH2OCH3、CH2OCF3、CH2OCF2H、CH2OCF2CF2H、CH2OCH2CF3、CH2OCF2CF3、 CH2SCH3、CH2CH2SCH3、CH2SCF3、CH2SCF2H、CH2SCF2CF2H、CH2SCH2CF3、CH2SCF2CF3、CH2NHCH3、CH2NHCF3、 CH2NHCF2H、CH2NHCF2CF2H、CH2NHCH2CF3、CH2NHCF2CF3、CF2NHCH3、CH2Ph、CH2OPh、CH2NHPh、 CH2OCH2Ph、CH2OCH2Py、
R2,R3It may be the same or different, be respectively selected from H, F, Cl, Br, I, CN, C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Alkene Base, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl amido, halo C1-C6Alkyl-carbonyl amine Base, C1-C6Alkoxycarbonylamino, halo C1-C6Alkyl sulphinyl amido, halo C1-C6Alkyl sulphonyl amido；
R4Selected from H, F, Cl, Br, I, CN, C1-C3Alkoxy, halo C1-C3Alkoxy, cyano group C1-C3Alkyl, cyano group C1-C3 Alkoxy, substituted or unsubstituted heteroaryl C1-C6Alkyl；
R5,R6It may be the same or different, be respectively selected from H, F, Cl, Br, I, CN, CF3、NO2；
R7Selected from H, C1-C6Alkyl；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C (CH3)2CH2SCH3、CH2CH2Cl、CH2CH2Br, cyclopropyl, CH2CH2CH2N(CH3)2、CH (CH3)CH2OH、
R9Selected from H or C1-C6Alkyl；
Present invention compound still more preferably is：In formula I
A, B may be the same or different, and be respectively and independently selected from O or S；
X is selected from H, F, Cl or CN；
Z is selected from N or CRd；Rd=H, F or Cl；
R1Selected from F, Cl, Br, I, CN, NO2、NH2、CHO、Si(CH3)3、CH3、CF3、CF2H、CH2CF3、CF2CF3, cyclopropyl,CH2C≡CI、CH2S(O)CH3、CH2S(O)CF3、CH2S(O)2CH3、CH2S(O)2CF3、CH2CN、CH2CH2CN、CH2OCH3、CH2OCF3、 CH2OCF2CF2H、CH2OCH2CF3、CH2SCH3、CH2SCF3、CH2NHCH3、CH2NHCF3、CH2Ph、CH2OPh、CH2NHPh、 CH2OCH2Ph、
R2,R3It may be the same or different, be respectively selected from H, F, Cl, Br, CN, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、 CH2F、CF2H、CF3、CH2Cl、CCl2H、CCl3、CFClH、NHCOCH3、NHCOCF3、NHC(O)OCH3、NHSOCF3、NHSO2CF3；
R4Selected from F, Cl, Br, CN, OCH3、OCH2CH3、OCF3、OCHF2、OCH2F、OCCl3、OCHCl2、OCH2Cl、 OCHFCl、OCF2CF2H、OCH2CF3、CH2CN、OCH2CN、
R5,R6It may be the same or different, be respectively selected from H, F, Cl, Br, CF3、CN；
R7Selected from H, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、C(CH3)3；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C (CH3)2CH2SCH3、CH2CH2Cl、CH2CH2Br, cyclopropyl, CH2CH2CH2N(CH3)2、CH (CH3)CH2OH、
R9Selected from H or CH3；
Present invention compound again still more preferably is：In formula I
A, B may be the same or different, and be respectively and independently selected from O or S；
X is selected from H, F, Cl or CN；
Z is selected from N or CRd；Rd=H, F or Cl；
R1Selected from F, Cl, Br, I, CN, NO2、NH2、CHO、Si(CH3)3、CH3、CF3、CF2H、CH2CF3、CF2CF3, cyclopropyl,CH2S(O)CF3、CH2S(O)2CF3、CH2CN、CH2CH2CN、CH2OCH3、CH2OCF3、CH2OCF2CF2H、 CH2OCH2CF3、CH2SCH3、CH2SCF3、CH2Ph、CH2OPh、 CH2OCH2Ph、
R2,R3It may be the same or different, be respectively selected from H, F, Cl, Br, CN, CH3、CH2CH3、CH(CH3)2、CH2F、CF2H、 CF3、CFClH、NHCOCH3、NHCOCF3、NHC(O)OCH3、NHSOCF3、NHSO2CF3；
R4Selected from F, Cl, Br, CN, OCH3、OCH2CH3、OCF3、OCHF2、OCH2F、OCHFCl、OCF2CF2H、OCH2CF3、 CH2CN、OCH2CN、
R5,R6It may be the same or different, be respectively selected from H, F, Cl, Br, CF3、CN；
R7Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C (CH3)2CH2SCH3, cyclopropyl,
R9Selected from H or CH3；
In the definition of compound of Formula I given above, collect term used and be typically defined as follows：
It is unsubstituted to represent that all substituents are all hydrogen.
The number of substituent can be 1~2 in substituted amido.
Halogen：Refer to fluorine, chlorine, bromine or iodine.
Alkyl：Straight or branched alkyl, such as methyl, ethyl, propyl group, isopropyl or the tert-butyl group.
Haloalkyl：Straight or branched alkyl, the hydrogen atom on these alkyl partly or entirely can be taken by halogen atom Generation.For example, haloalkyl such as chloromethyl, dichloromethyl, trichloromethyl, methyl fluoride, difluoromethyl or trifluoromethyl.
Alkoxy：Straight or branched alkyl, is connected in structure through oxygen atom key.
Halogenated alkoxy：Straight or branched alkoxyl, the hydrogen atom on these alkoxies can be partly or entirely former by halogen Son is replaced.For example, halogenated alkoxy such as chloromethane epoxide, dichloro methoxyl group, trichloromethoxy, fluorine methoxyl group, difluoromethoxy Base, trifluoromethoxy, chlorine fluorine methoxyl group or trifluoro ethoxy.
Alkenyl：Straight or branched simultaneously can there are double bond, such as vinyl or pi-allyl on any position.
Alkynyl：Straight or branched simultaneously can there are three keys, such as acetenyl or propargyl on any position.
Aryl moiety in aryl and aralkyl, aromatic yl alkenyl, sweet-smelling alkynyl, aryloxy group and aryloxy alkyl includes benzene Base or naphthyl.
Signified heteroaryl is to contain heteroatomic 5 yuan of rings of one or more N, O, S or 6 yuan of rings in the present invention.Such as pyridine, furan Mutter, pyrimidine, pyrazine, pyridazine, triazine, quinoline or benzofuran.
The compound of the present invention can exist as one or more stereoisomers.It will be appreciated by those skilled in the art that When concentration is big for other stereoisomers for a kind of stereoisomer, or when itself and other Enantiomer separations When, possibility is more active and/or may show favourable effect.In addition, those skilled in the art instruct how to separate, be enriched with And/or optionally prepare the stereoisomer.Therefore, the present invention includes the change selected from formula I, its N- oxide or its salt Compound.The compound of the present invention as the mixture of stereoisomer, single stereoisomer or can be used as optical forms In the presence of.
The compound that can be listed with table 1 below-table 262 illustrates the present invention, but does not limit the present invention.
Table 1, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=F, following chemical combination is chosen Thing, numbering is 1-1~1-709
Table 2, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 2-1~2-709.
Table 3, A=O, B=O, X=H, Z=N, R2=Cl, R3=F, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 3-1~3-709.
Table 4, A=O, B=O, X=H, Z=N, R2=Cl, R3=Br, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 4-1~4-709.
Table 5, A=O, B=O, X=H, Z=N, R2=Cl, R3=CF3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 5-1~5-709.
Table 6, A=O, B=O, X=H, Z=N, R2=Cl, R3=H, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 6-1~6-709.
Table 7, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 7-1~7-709
Table 8, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 8-1~8-709.
Table 9, A=O, B=O, X=H, Z=N, R2=CN, R3=F, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 9-1~9-709.
Table 10, A=O, B=O, X=H, Z=N, R2=CN, R3=Br, R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 10-1~10-709.
Table 11, A=O, B=O, X=H, Z=N, R2=CN, R3=CF3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 11-1~11-709.
Table 12, A=O, B=O, X=H, Z=N, R2=CN, R3=H, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 12-1~12-709.
Table 13, A=O, B=O, X=H, Z=N, R2=Br, R3=Cl, R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 13-1~13-709.
Table 14, A=O, B=O, X=H, Z=N, R2=Br, R3=CH3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 14-1~14-709.
Table 15, A=O, B=O, X=H, Z=N, R2=Br, R3=F, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 15-1~15-709.
Table 16, A=O, B=O, X=H, Z=N, R2=Br, R3=Br, R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 16-1~16-709.
Table 17, A=O, B=O, X=H, Z=N, R2=Br, R3=CF3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 17-1~17-709.
Table 18, A=O, B=O, X=H, Z=N, R2=Br, R3=H, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 18-1~18-709.
Table 19, A=O, B=O, X=H, Z=N, R2=F, R3=Cl, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 19-1~19-709.
Table 20, A=O, B=O, X=H, Z=N, R2=F, R3=CH3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 20-1~20-709.
Table 21, A=O, B=O, X=H, Z=N, R2=F, R3=F, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 21-1~21-709.
Table 22, A=O, B=O, X=H, Z=N, R2=F, R3=Br, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 22-1~22-709.
Table 23, A=O, B=O, X=H, Z=N, R2=F, R3=CF3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 23-1~23-709.
Table 24, A=O, B=O, X=H, Z=N, R2=F, R3=H, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 24-1~24-709.
Table 25, A=O, B=O, X=H, Z=N, R2=H, R3=Cl, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 25-1~25-709.
Table 26, A=O, B=O, X=H, Z=N, R2=H, R3=CH3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 26-1~26-709.
Table 27, A=O, B=O, X=H, Z=N, R2=H, R3=F, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 27-1~27-709.
Table 28, A=O, B=O, X=H, Z=N, R2=H, R3=Br, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 28-1~28-709.
Table 29, A=O, B=O, X=H, Z=N, R2=H, R3=CF3,R7=H, R9=H, R1During=F, choose such as table 1 The compound of identical substituent, numbering is 29-1~29-709.
Table 30, A=O, B=O, X=H, Z=N, R2=H, R3=H, R7=H, R9=H, R1During=F, choose such as the phase of table 1 With the compound of substituent, numbering is 30-1~30-709.
Table 31, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 31-1~31-709.
Table 32, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=Cl, choose such as table The compound of 1 identical substituent, numbering is 32-1~32-709.
Table 33, A=O, B=O, X=H, Z=N, R2=Cl, R3=F, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 33-1~33-709.
Table 34, A=O, B=O, X=H, Z=N, R2=Cl, R3=Br, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 34-1~34-709.
Table 35, A=O, B=O, X=H, Z=N, R2=Cl, R3=CF3,R7=H, R9=H, R1During=Cl, choose such as table The compound of 1 identical substituent, numbering is 35-1~35-709.
Table 36, A=O, B=O, X=H, Z=N, R2=Cl, R3=H, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 36-1~36-709.
Table 37, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 37-1~37-709.
Table 38, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=Cl, choose such as table The compound of 1 identical substituent, numbering is 38-1~38-709.
Table 39, A=O, B=O, X=H, Z=N, R2=CN, R3=F, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 39-1~39-709.
Table 40, A=O, B=O, X=H, Z=N, R2=CN, R3=Br, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 40-1~40-709.
Table 41, A=O, B=O, X=H, Z=N, R2=CN, R3=CF3,R7=H, R9=H, R1During=Cl, choose such as table The compound of 1 identical substituent, numbering is 41-1~41-709.
Table 42, A=O, B=O, X=H, Z=N, R2=CN, R3=H, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 42-1~42-709.
Table 43, A=O, B=O, X=H, Z=N, R2=Br, R3=Cl, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 43-1~43-709.
Table 44, A=O, B=O, X=H, Z=N, R2=Br, R3=CH3,R7=H, R9=H, R1During=Cl, choose such as table The compound of 1 identical substituent, numbering is 44-1~44-709.
Table 45, A=O, B=O, X=H, Z=N, R2=Br, R3=F, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 45-1~45-709.
Table 46, A=O, B=O, X=H, Z=N, R2=Br, R3=Br, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 46-1~46-709.
Table 47, A=O, B=O, X=H, Z=N, R2=Br, R3=CF3,R7=H, R9=H, R1During=Cl, choose such as table The compound of 1 identical substituent, numbering is 47-1~47-709.
Table 48, A=O, B=O, X=H, Z=N, R2=Br, R3=H, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 48-1~48-709.
Table 49, A=O, B=O, X=H, Z=N, R2=F, R3=Cl, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 49-1~49-709.
Table 50, A=O, B=O, X=H, Z=N, R2=F, R3=CH3,R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 50-1~50-709.
Table 51, A=O, B=O, X=H, Z=N, R2=F, R3=F, R7=H, R9=H, R1During=Cl, choose such as the phase of table 1 With the compound of substituent, numbering is 51-1~51-709.
Table 52, A=O, B=O, X=H, Z=N, R2=F, R3=Br, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 52-1~52-709.
Table 53, A=O, B=O, X=H, Z=N, R2=F, R3=CF3,R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 53-1~53-709.
Table 54, A=O, B=O, X=H, Z=N, R2=F, R3=H, R7=H, R9=H, R1During=Cl, choose such as the phase of table 1 With the compound of substituent, numbering is 54-1~54-709.
Table 55, A=O, B=O, X=H, Z=N, R2=H, R3=Cl, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 55-1~55-709.
Table 56, A=O, B=O, X=H, Z=N, R2=H, R3=CH3,R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 56-1~56-709.
Table 57, A=O, B=O, X=H, Z=N, R2=H, R3=F, R7=H, R9=H, R1During=Cl, choose such as the phase of table 1 With the compound of substituent, numbering is 57-1~57-709.
Table 58, A=O, B=O, X=H, Z=N, R2=H, R3=Br, R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 58-1~58-709.
Table 59, A=O, B=O, X=H, Z=N, R2=H, R3=CF3,R7=H, R9=H, R1During=Cl, choose such as table 1 The compound of identical substituent, numbering is 59-1~59-709.
Table 60, A=O, B=O, X=H, Z=N, R2=H, R3=H, R7=H, R9=H, R1During=Cl, choose such as the phase of table 1 With the compound of substituent, numbering is 60-1~60-709.
Table 61, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 61-1~61-709.
Table 62, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=CN, choose such as table The compound of 1 identical substituent, numbering is 62-1~62-709.
Table 63, A=O, B=O, X=H, Z=N, R2=Cl, R3=F, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 63-1~63-709.
Table 64, A=O, B=O, X=H, Z=N, R2=Cl, R3=Br, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 64-1~64-709.
Table 65, A=O, B=O, X=H, Z=N, R2=Cl, R3=CF3,R7=H, R9=H, R1During=CN, choose such as table The compound of 1 identical substituent, numbering is 65-1~65-709.
Table 66, A=O, B=O, X=H, Z=N, R2=Cl, R3=H, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 66-1~66-709.
Table 67, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 67-1~67-709.
Table 68, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=CN, choose such as table The compound of 1 identical substituent, numbering is 68-1~68-709.
Table 69, A=O, B=O, X=H, Z=N, R2=CN, R3=F, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 69-1~69-709.
Table 70, A=O, B=O, X=H, Z=N, R2=CN, R3=Br, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 70-1~70-709.
Table 71, A=O, B=O, X=H, Z=N, R2=CN, R3=CF3,R7=H, R9=H, R1During=CN, choose such as table The compound of 1 identical substituent, numbering is 71-1~71-709.
Table 72, A=O, B=O, X=H, Z=N, R2=CN, R3=H, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 72-1~72-709.
Table 73, A=O, B=O, X=H, Z=N, R2=Br, R3=Cl, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 73-1~73-709.
Table 74, A=O, B=O, X=H, Z=N, R2=Br, R3=CH3,R7=H, R9=H, R1During=CN, choose such as table The compound of 1 identical substituent, numbering is 74-1~74-709.
Table 75, A=O, B=O, X=H, Z=N, R2=Br, R3=F, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 75-1~75-709.
Table 76, A=O, B=O, X=H, Z=N, R2=Br, R3=Br, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 76-1~76-709.
Table 77, A=O, B=O, X=H, Z=N, R2=Br, R3=CF3,R7=H, R9=H, R1During=CN, choose such as table The compound of 1 identical substituent, numbering is 77-1~77-709.
Table 78, A=O, B=O, X=H, Z=N, R2=Br, R3=H, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 78-1~78-709.
Table 79, A=O, B=O, X=H, Z=N, R2=F, R3=Cl, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 79-1~79-709.
Table 80, A=O, B=O, X=H, Z=N, R2=F, R3=CH3,R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 80-1~80-709.
Table 81, A=O, B=O, X=H, Z=N, R2=F, R3=F, R7=H, R9=H, R1During=CN, choose such as the phase of table 1 With the compound of substituent, numbering is 81-1~81-709.
Table 82, A=O, B=O, X=H, Z=N, R2=F, R3=Br, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 82-1~82-709.
Table 83, A=O, B=O, X=H, Z=N, R2=F, R3=CF3,R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 83-1~83-709.
Table 84, A=O, B=O, X=H, Z=N, R2=F, R3=H, R7=H, R9=H, R1During=CN, choose such as the phase of table 1 With the compound of substituent, numbering is 84-1~84-709.
Table 85, A=O, B=O, X=H, Z=N, R2=H, R3=Cl, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 85-1~85-709.
Table 86, A=O, B=O, X=H, Z=N, R2=H, R3=CH3,R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 86-1~86-709.
Table 87, A=O, B=O, X=H, Z=N, R2=H, R3=F, R7=H, R9=H, R1During=CN, choose such as the phase of table 1 With the compound of substituent, numbering is 87-1~87-709.
Table 88, A=O, B=O, X=H, Z=N, R2=H, R3=Br, R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 88-1~88-709.
Table 89, A=O, B=O, X=H, Z=N, R2=H, R3=CF3,R7=H, R9=H, R1During=CN, choose such as table 1 The compound of identical substituent, numbering is 89-1~89-709.
Table 90, A=O, B=O, X=H, Z=N, R2=H, R3=H, R7=H, R9=H, R1During=CN, choose such as the phase of table 1 With the compound of substituent, numbering is 90-1~90-709.
Table 91, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=Br, choose such as table 1 The compound of identical substituent, numbering is 91-1~91-709.
Table 92, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=Br, choose such as table The compound of 1 identical substituent, numbering is 92-1~92-709.
Table 93, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=Br, choose such as table 1 The compound of identical substituent, numbering is 93-1~93-709.
Table 94, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=Br, choose such as table The compound of 1 identical substituent, numbering is 94-1~94-709.
Table 95, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=I, choose such as table 1 The compound of identical substituent, numbering is 95-1~95-709.
Table 96, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=I, choose such as table 1 The compound of identical substituent, numbering is 96-1~96-709.
Table 97, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=I, choose such as table 1 The compound of identical substituent, numbering is 97-1~97-709.
Table 98, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=I, choose such as table 1 The compound of identical substituent, numbering is 98-1~98-709.
Table 99, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=NO2When, choose such as table The compound of 1 identical substituent, numbering is 99-1~99-709.
Table 100, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=NO2When, choose as The compound of the identical substituent of table 1, numbering is 100-1~100-709.
Table 101, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=NO2When, choose as The compound of the identical substituent of table 1, numbering is 101-1~101-709.
Table 102, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=NO2When, choose as The compound of the identical substituent of table 1, numbering is 102-1~102-709.
Table 103, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2During CN, choose such as With the compound of the identical substituent of table 1, numbering is 103-1~103-709.
Table 104, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2During CN, choose such as With the compound of the identical substituent of table 1, numbering is 104-1~104-709.
Table 105, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2During CN, choose such as With the compound of the identical substituent of table 1, numbering is 105-1~105-709.
Table 106, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2During CN, choose such as With the compound of the identical substituent of table 1, numbering is 106-1~106-709.
Table 107, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=Si (CH3)3When, choose Such as the compound of the identical substituent of table 1, numbering is 107-1~107-709.
Table 108, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=Si (CH3)3When, choose Such as the compound of the identical substituent of table 1, numbering is 108-1~108-709.
Table 109, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=Si (CH3)3When, choose Such as the compound of the identical substituent of table 1, numbering is 109-1~109-709.
Table 110, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=Si (CH3)3When, choose Such as the compound of the identical substituent of table 1, numbering is 110-1~110-709.
Table 111, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH3When, choose as The compound of the identical substituent of table 1, numbering is 111-1~111-709.
Table 112, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH3When, choose as The compound of the identical substituent of table 1, numbering is 112-1~112-709.
Table 113, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH3When, choose as The compound of the identical substituent of table 1, numbering is 113-1~113-709.
Table 114, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH3When, choose as The compound of the identical substituent of table 1, numbering is 114-1~114-709.
Table 115, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CF3When, choose as The compound of the identical substituent of table 1, numbering is 115-1~115-709.
Table 116, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CF3When, choose as The compound of the identical substituent of table 1, numbering is 116-1~116-709.
Table 117, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CF3When, choose as The compound of the identical substituent of table 1, numbering is 117-1~117-709.
Table 118, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CF3When, choose as The compound of the identical substituent of table 1, numbering is 118-1~118-709.
Table 119, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=cyclopropyl, choose such as With the compound of the identical substituent of table 1, numbering is 119-1~119-709.
Table 120, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=cyclopropyl, choose Such as the compound of the identical substituent of table 1, numbering is 120-1~120-709.
Table 121, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=cyclopropyl, choose such as With the compound of the identical substituent of table 1, numbering is 121-1~121-709.
Table 122, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=cyclopropyl, choose Such as the compound of the identical substituent of table 1, numbering is 122-1~122-709.
Table 123, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=When, choose Such as the compound of the identical substituent of table 1, numbering is 123-1~123-709.
Table 124, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=When, choose Such as the compound of the identical substituent of table 1, numbering is 124-1~124-709.
Table 125, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=When, choose Such as the compound of the identical substituent of table 1, numbering is 125-1~125-709.
Table 126, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=When, choose Such as the compound of the identical substituent of table 1, numbering is 126-1~126-709.
Table 127, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2CF3When, choose such as With the compound of the identical substituent of table 1, numbering is 127-1~127-709.
Table 128, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2CF3When, choose such as With the compound of the identical substituent of table 1, numbering is 128-1~128-709.
Table 129, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2CF3When, choose such as With the compound of the identical substituent of table 1, numbering is 129-1~129-709.
Table 130, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2CF3When, choose such as With the compound of the identical substituent of table 1, numbering is 130-1~130-709.
Table 131, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CF2CF3When, choose such as With the compound of the identical substituent of table 1, numbering is 131-1~131-709.
Table 132, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CF2CF3When, choose such as With the compound of the identical substituent of table 1, numbering is 132-1~132-709.
Table 133, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CF2CF3When, choose such as With the compound of the identical substituent of table 1, numbering is 133-1~133-709.
Table 134, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CF2CF3When, choose such as With the compound of the identical substituent of table 1, numbering is 134-1~134-709.
Table 135, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2S(O)CH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 135-1~135-709
Table 136, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2S(O)CH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 136-1~136-709
Table 137, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2S(O)CH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 137-1~137-709
Table 138, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2S(O)CH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 138-1~138-709
Table 139, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2S(O)2CH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 139-1~139-709
Table 140, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2S(O)2CH3When, Choose such as the compound of the identical substituent of table 1, numbering is 140-1~140-709
Table 141, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2S(O)2CH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 141-1~141-709
Table 142, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2S(O)2CH3When, Choose such as the compound of the identical substituent of table 1, numbering is 142-1~142-709
Table 143, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2S(O)CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 143-1~143-709
Table 144, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2S(O)CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 144-1~144-709
Table 145, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2S(O)CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 145-1~145-709
Table 146, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2S(O)CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 146-1~146-709
Table 147, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2S(O)2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 147-1~147-709
Table 148, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2S(O)2CF3When, Choose such as the compound of the identical substituent of table 1, numbering is 148-1~148-709
Table 149, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2S(O)2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 149-1~149-709
Table 150, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2S(O)2CF3When, Choose such as the compound of the identical substituent of table 1, numbering is 150-1~150-709
Table 151, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2OCH3When, choose Such as the compound of the identical substituent of table 1, numbering is 151-1~151-709
Table 152, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2OCH3When, choose Such as the compound of the identical substituent of table 1, numbering is 152-1~152-709
Table 153, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2OCH3When, choose Such as the compound of the identical substituent of table 1, numbering is 153-1~153-709
Table 154, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2OCH3When, choose Such as the compound of the identical substituent of table 1, numbering is 154-1~154-709
Table 155, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2OCH2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 155-1~155-709
Table 156, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2OCH2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 156-1~156-709
Table 157, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2OCH2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 157-1~157-709
Table 158, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2OCH2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 158-1~158-709
Table 159, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2SCH3When, choose Such as the compound of the identical substituent of table 1, numbering is 159-1~159-709
Table 160, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2SCH3When, choose Such as the compound of the identical substituent of table 1, numbering is 160-1~160-709
Table 161, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2SCH3When, choose Such as the compound of the identical substituent of table 1, numbering is 161-1~161-709
Table 162, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2SCH3When, choose Such as the compound of the identical substituent of table 1, numbering is 162-1~162-709
Table 163, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=CHO, choose as The compound of the identical substituent of table 1, numbering is 163-1~163-709
Table 164, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=CHO, choose as The compound of the identical substituent of table 1, numbering is 164-1~164-709
Table 165, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=CHO, choose as The compound of the identical substituent of table 1, numbering is 165-1~165-709
Table 166, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=CHO, choose as The compound of the identical substituent of table 1, numbering is 166-1~166-709
Table 167, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=NH2When, choose as The compound of the identical substituent of table 1, numbering is 167-1~167-709
Table 168, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=NH2When, choose as The compound of the identical substituent of table 1, numbering is 168-1~168-709
Table 169, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=NH2When, choose as The compound of the identical substituent of table 1, numbering is 169-1~169-709
Table 170, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=NH2When, choose as The compound of the identical substituent of table 1, numbering is 170-1~170-709
Table 171, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CF2During H, choose as The compound of the identical substituent of table 1, numbering is 171-1~171-709
Table 172, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CF2During H, choose such as With the compound of the identical substituent of table 1, numbering is 172-1~172-709
Table 173, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CF2During H, choose as The compound of the identical substituent of table 1, numbering is 173-1~173-709
Table 174, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CF2During H, choose such as With the compound of the identical substituent of table 1, numbering is 174-1~174-709
Table 175, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2OCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 175-1~175-709
Table 176, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2OCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 176-1~176-709
Table 177, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2OCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 177-1~177-709
Table 178, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2OCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 178-1~178-709
Table 179, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2CH2During CN, choose Such as the compound of the identical substituent of table 1, numbering is 179-1~179-709
Table 180, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2CH2During CN, choose Such as the compound of the identical substituent of table 1, numbering is 180-1~180-709
Table 181, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2CH2During CN, choose Such as the compound of the identical substituent of table 1, numbering is 181-1~181-709
Table 182, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2CH2During CN, choose Such as the compound of the identical substituent of table 1, numbering is 182-1~182-709
Table 183, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2CH2OCH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 183-1~183-709
Table 184, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2CH2OCH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 184-1~184-709
Table 185, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2CH2OCH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 185-1~185-709
Table 186, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2CH2OCH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 186-1~186-709
Table 187, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2OCF2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 187-1~187-709
Table 188, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2OCF2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 188-1~188-709
Table 189, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2OCF2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 189-1~189-709
Table 190, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2OCF2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 190-1~190-709
Table 191, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2OCF2CF2During H, choosing Take such as the compound of the identical substituent of table 1, numbering is 191-1~191-709
Table 192, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2OCF2CF2During H, Choose such as the compound of the identical substituent of table 1, numbering is 192-1~192-709
Table 193, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2OCF2CF2During H, choosing Take such as the compound of the identical substituent of table 1, numbering is 193-1~193-709
Table 194, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2OCF2CF2During H, Choose such as the compound of the identical substituent of table 1, numbering is 194-1~194-709
Table 195, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2OCF2During H, choose Such as the compound of the identical substituent of table 1, numbering is 195-1~195-709
Table 196, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2OCF2During H, choose Such as the compound of the identical substituent of table 1, numbering is 196-1~196-709
Table 197, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2OCF2During H, choose Such as the compound of the identical substituent of table 1, numbering is 197-1~197-709
Table 198, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2OCF2During H, choose Such as the compound of the identical substituent of table 1, numbering is 198-1~198-709
Table 199, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2CH2SCH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 199-1~199-709
Table 200, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2CH2SCH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 200-1~200-709
Table 201, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2CH2SCH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 201-1~201-709
Table 202, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2CH2SCH3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 202-1~202-709
Table 203, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2SCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 203-1~203-709
Table 204, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2SCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 204-1~204-709
Table 205, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2SCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 205-1~205-709
Table 206, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2SCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 206-1~206-709
Table 207, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2SCH2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 207-1~207-709
Table 208, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2SCH2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 208-1~208-709
Table 209, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2SCH2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 209-1~209-709
Table 210, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2SCH2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 210-1~210-709
Table 211, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2SCF2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 211-1~211-709
Table 212, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2SCF2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 212-1~212-709
Table 213, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2SCF2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 213-1~213-709
Table 214, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2SCF2CF3When, choosing Take such as the compound of the identical substituent of table 1, numbering is 214-1~214-709
Table 215, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2SCF2During H, choose Such as the compound of the identical substituent of table 1, numbering is 215-1~215-709
Table 216, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2SCF2During H, choose Such as the compound of the identical substituent of table 1, numbering is 216-1~216-709
Table 217, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2SCF2During H, choose Such as the compound of the identical substituent of table 1, numbering is 217-1~217-709
Table 218, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2SCF2During H, choose Such as the compound of the identical substituent of table 1, numbering is 218-1~218-709
Table 219, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2SCF2CF2During H, choosing Take such as the compound of the identical substituent of table 1, numbering is 219-1~219-709
Table 220, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2SCF2CF2During H, Choose such as the compound of the identical substituent of table 1, numbering is 220-1~220-709
Table 221, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2SCF2CF2During H, choosing Take such as the compound of the identical substituent of table 1, numbering is 221-1~221-709
Table 222, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2SCF2CF2During H, Choose such as the compound of the identical substituent of table 1, numbering is 222-1~222-709
Table 223, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2OCH2During Ph, choosing Take such as the compound of the identical substituent of table 1, numbering is 223-1~223-709
Table 224, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2OCH2During Ph, choosing Take such as the compound of the identical substituent of table 1, numbering is 224-1~224-709
Table 225, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2OCH2During Ph, choosing Take such as the compound of the identical substituent of table 1, numbering is 225-1~225-709
Table 226, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2OCH2During Ph, choosing Take such as the compound of the identical substituent of table 1, numbering is 226-1~226-709
Table 227, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=When, choose such as the compound of the identical substituent of table 1, numbering is 227-1~227-709
Table 228, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=When, choose such as the compound of the identical substituent of table 1, numbering is 228-1~228-709
Table 229, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=When, choose such as the compound of the identical substituent of table 1, numbering is 229-1~229-709
Table 230, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=When, choose such as the compound of the identical substituent of table 1, numbering is 230-1~230-709
Table 231, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=When, choose such as the compound of the identical substituent of table 1, numbering is 231-1~231-709
Table 232, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=When, choose such as the compound of the identical substituent of table 1, numbering is 232-1~232-709
Table 233, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=When, choose such as the compound of the identical substituent of table 1, numbering is 233-1~233-709
Table 234, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=When, choose such as the compound of the identical substituent of table 1, numbering is 234-1~234-709
Table 235, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1=CH2NHCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 235-1~235-709
Table 236, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1=CH2NHCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 236-1~236-709
Table 237, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1=CH2NHCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 237-1~237-709
Table 238, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1=CH2NHCF3When, choose Such as the compound of the identical substituent of table 1, numbering is 238-1~238-709
Table 239, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=F, choose such as table The compound of 1 identical substituent, numbering is 239-1~239-709
Table 240, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=F, choose as The compound of the identical substituent of table 1, numbering is 240-1~240-709
Table 241, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=F, choose such as table The compound of 1 identical substituent, numbering is 241-1~241-709
Table 242, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=F, choose as The compound of the identical substituent of table 1, numbering is 242-1~242-709
Table 243, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=Cl, choose as The compound of the identical substituent of table 1, numbering is 243-1~243-709
Table 244, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=Cl, choose as The compound of the identical substituent of table 1, numbering is 244-1~244-709
Table 245, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=Cl, choose as The compound of the identical substituent of table 1, numbering is 245-1~245-709
Table 246, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=Cl, choose as The compound of the identical substituent of table 1, numbering is 246-1~246-709
Table 247, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, R1During=CN, choose as The compound of the identical substituent of table 1, numbering is 247-1~247-709
Table 248, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, R1During=CN, choose as The compound of the identical substituent of table 1, numbering is 248-1~248-709
Table 249, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, R1During=CN, choose as The compound of the identical substituent of table 1, numbering is 249-1~249-709
Table 250, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, R1During=CN, choose as The compound of the identical substituent of table 1, numbering is 250-1~250-709
Table 251, A=O, B=O, X=H, R2=Cl, R3=Cl, R7=H, R9=H, R1During=F, following compound is chosen, Numbering is 251-1~251-980.
Table 252, A=O, B=O, X=H, R2=Cl, R3=CH3,R7=H, R9=H, R1During=F, choose such as the phase of table 251 With the compound of substituent, numbering is 252-1~252-980.
Table 253, A=O, B=O, X=H, R2=CN, R3=Cl, R7=H, R9=H, R1During=F, choose such as the phase of table 251 With the compound of substituent, numbering is 253-1~253-980.
Table 254, A=O, B=O, X=H, R2=CN, R3=CH3,R7=H, R9=H, R1During=F, choose such as the phase of table 251 With the compound of substituent, numbering is 254-1~254-980.
Table 255, A=O, B=O, X=H, R2=Cl, R3=Cl, R7=H, R9=H, R1During=Cl, choose such as the phase of table 251 With the compound of substituent, numbering is 255-1~255-980.
Table 256, A=O, B=O, X=H, R2=Cl, R3=CH3,R7=H, R9=H, R1During=Cl, choose such as table 251 The compound of identical substituent, numbering is 256-1~256-980.
Table 257, A=O, B=O, X=H, R2=CN, R3=Cl, R7=H, R9=H, R1During=Cl, choose such as the phase of table 251 With the compound of substituent, numbering is 257-1~257-980.
Table 258, A=O, B=O, X=H, R2=CN, R3=CH3,R7=H, R9=H, R1During=Cl, choose such as table 251 The compound of identical substituent, numbering is 258-1~258-980.
Table 259, A=O, B=O, X=H, R2=Cl, R3=Cl, R7=H, R9=H, R1During=CN, choose such as the phase of table 251 With the compound of substituent, numbering is 259-1~259-980.
Table 260, A=O, B=O, X=H, R2=Cl, R3=CH3,R7=H, R9=H, R1During=CN, choose such as table 251 The compound of identical substituent, numbering is 260-1~260-980.
Table 261, A=O, B=O, X=H, R2=CN, R3=Cl, R7=H, R9=H, R1During=CN, choose such as the phase of table 251 With the compound of substituent, numbering is 261-1~261-980.
Table 262, A=O, B=O, X=H, R2=CN, R3=CH3,R7=H, R9=H, R1During=CN, choose such as table 251 The compound of identical substituent, numbering is 262-1~262-980.
The compound of Formula I of the present invention can be prepared in accordance with the following methods：
Method one：
Compound of Formula I can be as the oxazine ketone compounds and R shown in formula II9Lg (Lg is leaving group, such as halogen, Alkyl or aryl sulphonic acid ester or alkyl sulfate) reaction be made intermediate II ', then with HNR7R8Reaction is made：
Method two：
Compound of Formula I can be as the oxazine ketone compounds and HNR shown in formula II7R8Intermediate compound I is made in reaction ', then with R9Lg (Lg is leaving group, such as halogen, alkyl or aryl sulphonic acid ester or alkyl sulfate) reactions are made：
Method three：
Compound of Formula I can be as the compound shown in general formula III and (Cl3CO)2The obtained intermediate compound IV of CO reactions, then with R9The obtained intermediate V of Lg (Lg is leaving group, such as halogen, alkyl or aryl sulphonic acid ester or alkyl sulfate) reactions, then with HNR7R8Intermediate VI is made in reaction, is finally made with pyrazole acyl chloride reaction.Wherein pyrazole acyl chloride can be passed through normal by corresponding carboxylic acid The method of rule is made, and is such as reacted with thionyl chloride：
Each group is as defined above in formula.
Reaction is carried out in a solvent, and suitable is selected from such as acetonitrile, tetrahydrofuran, ether, dichloromethane, chloroform, acetic acid second Ester, dioxane, toluene etc..
Reaction temperature in room temperature between solvent boiling point temperature, usually 20~100 DEG C.
Reaction time is 30 minutes to 20 hours, usually 1~10 hour.
Involved raw material midbody and source are as follows in above-mentioned preparation method：
Oxazine ketone compounds shown in formula II, Reviews are shown in Bioorganic and Medicinal Chemistry 2008,8,2095-2103 and J.Heterocyclic Chemistry 1999,36,563-588.Its preparation side Method is with reference to WO03015519, WO2005118552 method.
Anthranilic acid compound shown in general formula III, can be made by aromatic hydrocarbons through two-step reaction, and reference literature is such as Under：Organic Synthesis,Coll.Vol.10.p.23(2004)；Vol.79,p.196(2002)； Adv.Heterocycl.Chem.1975,18,1-58；Journal of the Brazilian Chemical Society 2001,12(3),273-324；Angew.Chem.Int.Ed.Engl.1980,19,222-223.
The preparation method of carboxylic acid compound shown in formula VII is with reference to WO2006062978, WO03015519.
The present invention compound of Formula I to agriculture, civilian and zoo technical field harmful insect adult, larva and ovum all Show high insecticidal activity.Part of compounds shows preferable bactericidal activity.Therefore, the present invention also includes formula I chemical combination Thing in agriculture and other fields as insecticide and/or bactericide application.
Especially, compound of Formula I is active to following section and the important kind of purpose：Lepidoptera (Beet armyworm category, real noctuid Category, straw borer spp, codling moth etc.).For example to European corn borer, sugarcane borer, codling moth, codling moth, Gypsymoth etc. is largely effective, particularly to diamondback moth activity more preferably, good effect is obtained with very low dosage.Together When, part of compounds of the invention shows preferable bactericidal activity, available for preventing and treating rice blast, cucumber downy mildew, charcoal Subcutaneous ulcer disease.
Meanwhile, compound of Formula I has hypotoxicity to many beneficial insects and acarid, mammal, fish, bird, and There is no phytotoxicity.
Due to its positive characteristic, above-claimed cpd is advantageously used for protecting agriculture and the important crop of horticulture, family Poultry and breeding stock, and the environment that often goes of the mankind is from the injury of harmful insect and fungi.
To obtain ideal effect, the consumption of compound changes because of various factors, such as compound used therefor, the work protected in advance Thing, the species of harmful organism, gradient of infection, weather conditions, application method, the formulation used.
The compound dosage of 10 grams -5 kilograms of per hectare can provide sufficient preventing and treating.
Another object of the present invention is further related to by applying compound of Formula I, preventing and treating agricultural and the important crop of horticulture And/or the insect in the environment that often goes of domestic animal and breeding stock and/or the mankind and/or the method for plant pathogenic fungi.Especially, change The consumption of compound changes in 10 grams -5 kilograms of per hectare.
The use of the composition containing one or more compound of Formula I is typically beneficial to be applied to agricultural.
Therefore, another object of the present invention design containing one or more compound of Formula I as active component desinsection and/ Or bactericidal composition.
The type of service of composition can be dry powder, wettable powder, missible oil, microemulsion, paste, granule, solution, outstanding Floating agent etc.：Being selected from for types of compositions depends on specific application.
Composition is prepared in a known manner, such as in the presence of optional surfactant, by solvent medium and/ Or solid diluent or dissolving active material.
Available solid diluent or carrier are for example：Silica, kaolin, bentonite, talcum, diatomite, white clouds Stone, calcium carbonate, magnesia, chalk, clay, synthetic silicate Attagel, sepiolite etc..
Than water, available liquid diluent also includes aromatic organic solvent (mixture, the chlorine of dimethylbenzene or alkylbenzene Benzene etc.), paraffin (petroleum distillate), alcohols (methanol, propyl alcohol, butanol, octanol, glycerine), esters (ethyl acetate, isobutyl acetate Deng), ketone (cyclohexanone, acetone, acetophenone, isophorone, ethyl pentyl group ketone etc.), amide-type (DMF, N- Methyl pyrrolidone etc.).
Available surfactant be alkylsulfonate, alkylaryl sulfonates, polyoxyethanyl alkyl phenol, sorbierite it is poly- Sodium, calcium, triethyl group or the triethanolamine salt of oxygen vinyl acetate, lignosulfonates etc..
Composition, which can also contain special additive, is used for specific purpose, such as containing adhesive such as Arabic gum, poly- second Enol, polyvinylpyrrolidone etc..
The concentration of active component can be according to active component, application target, environmental condition and the system of use in above-mentioned composition Agent type and change in a wide range.Generally, the concentration of active component is 1%-90%, preferably 5%-60%.
It is possible if desired to which other active components that addition can be compatible with compound of Formula I into composition, such as other Acaricide/insecticide, fungicide, plant growth regulator, antibiotic, herbicide, fertilizer.
The compound method of several formulations is exemplified below：
The preparation of suspending agent：Active component content is 5%-35% in common prescription.Using water as medium, by active compound, disperse Agent, suspending agent and antifreeze etc. are added in sand mill, be ground, suspending agent is made.
The preparation of aqueous emulsion：Active compound, solvent and emulsifying agent are added together, make to be dissolved into homogeneous oil phase.By water, antifreeze Etc. being mixed, as homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added to oil phase or oil phase is added to aqueous phase, formed and divided Dissipate the good aqueous emulsion of property.The aqueous emulsion active component content of the present invention is generally 5%-15%.To prepare emulsifiable concentrate, the present invention Compound be dissolvable in water one or several kinds of mixed solvents, emulsifying agent is added to strengthen dispersion effect of the compound in water.
The preparation of wettable powder：It is by recipe requirements, active compound, various surfactants and solid diluent etc. is fully mixed Close, after ultra-fine pulverizer disintegrating, that is, obtain predetermined content (such as 10%-40%) wettable powder product.It is suitable to prepare In the wettable powder of sprinkling, compound of the invention can be with finely ground solid powder such as clay, electrodeless silicate, carbonic acid Salt and wetting agent, adhesive and/or dispersant composition mixture.
The preparation of water-dispersible granules：Active compound and powdered solid diluents, wetting spreader-sticker and adhesive etc. are mixed Close and crush, add water after kneading, add and granulated in the granulating agent equipped with certain specification screen cloth, then again through drying, screening (pressing screen cloth scope).Also active compound, dispersant, disintegrant and wetting agent and solid diluent can be added in sand mill, using water as Medium milling, is made suspending agent, then carries out spray drying granulation, is typically formulated content for 20%-30% granular products.
Embodiment
Example is used for further illustrating the present invention in detail below, but the present invention is limited to absolutely not these examples.
Synthetic example
Embodiment 1：Compound 1-1 preparation
At room temperature, II-1 (1.0mmol, 0.491g), 5 milliliters of N, N- dimethyl formyls are added into 25 milliliters of reaction bulbs Amine, the lower ammoniacal liquor for adding 0.102 gram 25% of stirring, room temperature reaction.TLC is monitored after completion of the reaction, and reaction solution is added drop-wise into 30 millis Rise in water, separate out solid, suction filtration is washed, dries, obtain product 0.315g, i.e. compound 1-1, yield 62%.
Embodiment 2：Compound 1-2 preparation
At room temperature, II-1 (1.0mmol, 0.491g), 5 milliliters of N, N- dimethyl formyls are added into 25 milliliters of reaction bulbs Amine, the lower methylamine water solution for adding 0.116 gram 40% of stirring, room temperature reaction.TLC is monitored after completion of the reaction, and reaction solution is added dropwise Into 30 milliliters of water, solid is separated out, suction filtration is washed, dries, obtain product 0.334g, i.e. compound 1-2, yield 64%.
Embodiment 3：Compound 1-10 preparation
At room temperature, II-1 (1.0mmol, 0.491g), 5 milliliters of N, N- dimethyl formyls are added into 25 milliliters of reaction bulbs Amine, stirring is lower to add (CH3)2CHNH2(1.5mmol, 0.089g), room temperature reaction.TLC is monitored after completion of the reaction, will react drop It is added in 30 milliliters of water, separates out solid, suction filtration washs, dries, obtain product 0.336g, i.e. compound 1-10, yield 61%.
Formula I other compounds can be made with the logical preparation method provided of the present invention.
Fusing point and mass spectrum (ESI) data of partial Formula I are as follows：
Compound 1-1：126-128 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):505.7/507.7/509.7
Compound 1-2：233-235 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):519.7/521.7/523.7
Compound 1-3：205-207 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):533.7/535.7/537.7
Compound 1-10：116-118 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):547.7/549.7/551.7
Compound 1-20：186-188 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):545.7/547.7/549.7
Compound 1-21：211-213 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):559.7/561.7/563.7
Compound 1-37：210-212 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):589.7/591.7/593.7
Compound 1-39：223-225 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):630.7/632.7/634.7
Compound 31-1：145-147 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):521.7/523.7/525.7
Compound 31-2：240-242 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):535.7/537.7/539.7
Compound 31-3：227-229 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):549.7/551.7/553.7
Compound 31-10：122-124 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):563.7/565.7/567.7
Compound 31-20：223-225 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):561.7/563.7/565.7
Compound 31-37：250-252 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):605.7/607.7/609.7
Compound 31-39：214-216 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):648.7/650.7/652.7
Compound 91-2：230-232 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):581.6/583.6/585.6
Compound 91-10：127-129 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):609.7/611.7/613.7
Compound 111-2：198-200 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):515.7/517.7/519.7
Compound 111-10：125-127 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):543.8/545.8/547.8
Example of formulations (each component addition is weight percentage, and reactive compound folding hundred is post-dised)
Embodiment 4:30% wettable powder
Compound 1-152, various surfactants and solid diluent etc. are sufficiently mixed, through ultra-fine pulverizer disintegrating Afterwards, and obtain 30% wettable powder product
Embodiment 5:20% suspending agent
Using water as medium, compound 1-218, dispersant, suspending agent and antifreeze etc. are added in sand mill, ground Mill, is made suspending agent.
Embodiment 6:60% water-dispersible granules
Compound 1-220 and powdered solid diluents, wetting spreader-sticker and adhesive etc. are subjected to co-grinding, added water After kneading, granulated in the comminutor for adding 10-100 eye mesh screens, then again through drying, screening (presses screen cloth scope).
Embodiment 7:10% aqueous emulsion
Compound 1-264, solvent and emulsifying agent are added together, make to be dissolved into homogeneous oil phase.Water, antifreeze etc. are mixed Together, as homogeneous aqueous phase.Under high velocity agitation, aqueous phase and oil phase are mixed, forms the aqueous emulsion of favorable dispersibility.
Embodiment 8:25% suspending agent
Using water as medium, compound 1-257, dispersant, suspending agent and antifreeze etc. are added and are ground in sand mill, Suspending agent is made.
Embodiment 9:20% wettable powder
Compound 1-271, various surfactants and solid diluent etc. are sufficiently mixed, through ultra-fine pulverizer disintegrating Afterwards, that is, obtain 20% wettable powder product.
Biological activity determination embodiment
The pesticide and miticide actility of example 10 is determined
The compounds of this invention can prevent and treat following insect：
Lepidoptera (moth and butterfly)：It is diamond-back moth, beet armyworm (beet armyworm), rice leaf roller, South America maize seedling phycitid, brown Argyrotaenia spp category kind, lichee litchi, earias fabia, adoxophyes moth, earias insulana, tiger category kind (cutworm), rice Cnaphalocrocis spp (meadow leaf roller), small cutworm (black cutworm), Earias kind (bollworm), Chlumetia transversa Walker, west Southern cornstalk crambid, cotton leaf ripple noctuid (cotton leafworm), oriental fruit months (east heart-eating worm), small sugarcane borer, sliver gelechiid, bean powder Butterfly category kind, high jute bridge night, snout moth's larva category kind (stem borer), the wooden stupid moth (wooden stupid moth) of fragrance, Anticarsia, Diaphania kind (moth stem Worm), the stupid moth of fruittree leafroller, apple (codling moth), rose leaf roller, high pea moth pod, blue or green Eimeria kind (noctuid), bag moth (bagworm), roll up the wild snout moth's larva of moth category kind, beanpod (beans open country snout moth's larva), tangerine Argyrotaenia spp (citrus leaf-roller), lopper worm (dish march moth), cotton Leaf lyonetid, Agrotis kind (cutworm), tobacco budworm, shallow brown apple moth, Lee's Grapholita spp (Li Guoe), Malacosoma Plant, thin moth category plants (leaf miner), Heliothis kind (noctuid), former cutworm, straw borer spp kind, peach fruit moth (peach fruit moth), oil Palm bag moth, the wild snout moth's larva of the white wing of eggplant, the real noctuid (corn borer ridge (snout moth's larva ridge worm/bollworm)) of paddy, bollworm, rose Choristoneura spp, beans are white The stupid moth of line cutworm, tomato, thin moth category kind, the brown volume moth of boundary (common glucose leaf roller), east moth fruit moth (the sub- food heart of peach (apricot) Worm), it is first by green noctuid, small tomato moth, European corn borer (European corn borer), treble cut snout moth (bean pyralid), Hellula undalis, Thin moth category kind (leaf miner), Noctua kind, Indarbela category kind (root moth), boundary Noctua kind (cutworm), 3 water snout moth's larvas (rice leaf roller), Sesamia inferens, winter looper, India paddy spot moth, Pectinophora gossypiella (pink bollworm), variegated cutworm, grape are small Leaf roller, grape berry moth, African Bodhidharma swallowtail butterfly, gypsymoth, meal moth category kind (a powder snout moth's larva), Mediterranean flour moth, coffee leafminer, Apple leaf miner (apple leaf miner), cabbage looper, gelechiid, armyworm, phthorimaea operculella, yellow rice borer, powder stem snout moth's larva, emerging Noctua Kind of (root moth), soybean noctuid, ligustrum fine tortricidae (grape berry moth), Spodoptera kind (armyworm), pilleriana, The stupid moth of pears leopard, tangerine fruit ermine moth, Spodopterafrugiperda (autumn armyworm), olive ermine moth, cabbage butterfly (external cabbage caterpillar), Loxagrotis category kind (noctuid), apple brown bortrix, pear leaf blister moth, Crambus Fabricius kind, citrus leaf lyonetid, casemaking clothes moth, mythimna separata category kind (night Moth), Yponomeuta kind, southern spodoptera (southern armyworm), Erionota thorax (Linne), meal moth, moth stem night high category kind (stem borer), cigarette Grass meal phycitid (tobacco snout moth's larva), the stupid moth of coffee leopard, Epimeces category kind, angle sword Noctua kind (stem borer), night steinernema, looper, The brown slug moth of Liriomyza brponiae, copper stain.
Homoptera (aleyrodid, aphid, leafhopper, a red-spotted lizard)：Aphid a red-spotted lizard category kind (aphid), rhopalosiphum padi, green bugs (wheat y-bend Aphid), corn tree louse (corn leaf aphids), sound Aphis kind (aphid), Trialeurodes vaporariorum Westwood (greenhouse whitefly), olive pearl lecanium (black a red-spotted lizard), arrow point Clam (arrow a red-spotted lizard), grain aphid (Britain's wheat aphid), variegation Aphis kind (aphid), knot wing trialeurodes vaporariorum, pearl lecanium category kind (a red-spotted lizard), white powder Pediculus kind (aleyrodid), white backed planthopper, sharp armored scale category kind (a red-spotted lizard), line lecanium category kind (a red-spotted lizard), rice green leafhopper (greenery cicada), ebony shield A red-spotted lizard, theatre armored scale (san jose scale), four line leafhopper (Aster tataricus leafhopper), froghopper category kind (spittle insects), Acyrthosiphon dirhodum (rose wheat Aphid), mealybug category kind of (mealybug), black peach aphid (black peach aphid), the clean mealybug of pineapple, rice green leafhopper category kind (leafhopper), a stern line mealybug category kind (powder A red-spotted lizard), brown paddy plant hopper, Physokermes piceae, chaff piece armored scale, grape phylloxera, popcorn wing plant hopper, acyrthosiphum pisim, Aspidiotus category kind of (a red-spotted lizard), ash Plant hopper, blow cotton a red-spotted lizard, it is asparagus tubule aphid (asparagus aphid), adelgid kind, rose aphid (rose aphid), the pink bad aphid of apple, sweet Blue powder lice (cabbage aleyrodid), grain aphid (Britain's wheat aphid), white wheel armored scale category kind, long tube Aphis kind, cotten aphid, lepidosaphes shimer Kind, Diuraphis noxia (Russian aphid), lecanium category kind of (a red-spotted lizard), Aleurodicus dispersus, Aleyrodes kind (aleyrodid), brevicoryne brassicae (cabbage aphid), It is root of Beijing euphorbia Macrosiphus spp (potato aphid), velvet aleyrodid (whitefly in bt cotton), mango yellow line leafhopper, froghopper category kind of (leafhopper), apple aphid, red Circle a red-spotted lizard (the red a red-spotted lizard in California), green jassids category kind (leafhopper), ceroplastes rubens, sweet potato whitefly, snow armored scale category kind (a red-spotted lizard), Aphis (aphid), Bemisia argentifolii, apple aphid, soft wax a red-spotted lizard category kind (a red-spotted lizard), eggplant are planted without net aphid (digitalis aphid).
Insecticidal activity assay experiment has been carried out to several insects with the compounds of this invention.Method for measuring is as follows：
After testing compound DMF dissolves, needed for being diluted to the water containing 0.1% Tween 80 Concentration.
1st, using diamondback moth, beet armyworm as target, insecticidal activity assay is carried out using immersion method.Investigate within 2-3 days after processing The death rate of target.Partial test result is as follows：
Liquor strength be 20ppm when, compound 1-2,1-10,1-37,31-2,31-10,31-37,91-2,91-10, 111-2,111-10 are to the diamondback moth death rate up to 100%；Compound 1-2,1-10,1-37,31-2,31-10,91-2,91-10, 111-2,111-10 are to the beet armyworm death rate up to 100%.
When liquor strength is 4ppm, compound 1-2,1-10,1-37,31-2,31-10,31-37,91-2,91-10,111- 10 pairs of diamondback moth death rates are up to 100%；Compound 1-2,1-10,31-2,31-10,91-2,91-10,111-10 are to beet armyworm The death rate is up to 100%.
When liquor strength is 1ppm, compound 1-2,1-10,31-2,31-10,91-2,91-10,111-10 are to diamondback moth The death rate is up to 100%；Compound 1-2,1-10,31-2,31-10,91-2,91-10 are to the beet armyworm death rate up to 100%.
When liquor strength is 0.5ppm, compound 1-2,1-10,31-2,31-10,91-2 reach to the diamondback moth death rate 100%；Compound 31-2,31-10 is to the beet armyworm death rate up to 100%.
When liquor strength is 0.25ppm, compound 1-2,1-10,31-2,31-10,91-2 reach to the diamondback moth death rate 100%；
When liquor strength is 0.05ppm, compound 1-2,1-10,31-2,31-10 are to the diamondback moth death rate up to more than 80%；
According to above method, choose compound 1-2 and carry out killing small with known compound Rynaxypyr and cyanogen insect amide Diamond-back moth activity parallel determination.Experimental result see the table below：
Kill diamondback moth determination of activity table：
Compound number Concentration (ppm) The death rate (%)
1-2 0.025 90
Rynaxypyr 0.025 28
Cyanogen insect amide 0.025 30
2nd, using aphid as target, insecticidal activity assay is carried out using Potter spray towers spray-on process, investigated within 2-3 days after processing The death rate of target.Partial test result is as follows：
When liquor strength is 4ppm, compound 1-2,1-10,31-2,31-10 are to the aphid death rate up to more than 90%；
3rd, using striped rice borer as target, insecticidal activity assay is carried out using immersion method, the death of 2-3 days investigation targets after processing Rate.Partial test result is as follows：
When liquor strength is 4ppm, compound 1-2,1-10,31-10 are to the striped rice borer death rate up to 100%.
According to above method, compound 1-2,1-10,31-10 and known compound Rynaxypyr and cyanogen worm acyl are chosen Amine carries out killing the active parallel determination of striped rice borer.Experimental result see the table below：
Kill striped rice borer determination of activity table：
Compound number Concentration (ppm) The death rate (%)
1-2 4 100
1-10 4 100
31-10 4 100
Rynaxypyr 4 50
Cyanogen insect amide 4 20

Claims (10)

1. a kind of substituted pyrazolecarboxylic amides compound, as shown in formula I：
In formula：
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2、NH2、NHCH3、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
X is selected from H, halogen, CN, NO2、NH2, CHO, CH=NOCH3, CH=NNHCH3, CH=NN (CH3)2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
Z is selected from N or CRb；Rb=H, halogen or NO2；
R1Selected from halogen, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, oxa- C2-C8Cycloalkyl, azepine C2-C8Cycloalkyl, thia C2-C8Cycloalkyl, C2-C6 Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl C1-C6Alkyl, halo C1-C6Alkane is sub- Sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfinyl C1-C6Alkyl, halo C1-C6Alcoxyl sulfinyl C1-C6Alkyl, C1-C6Alkane Sulfonyl C1-C6Alkyl, halo C1-C6Alkane sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfonyl C1-C6Alkyl, halo C1-C6Alcoxyl Sulfonyl C1-C6Alkyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogeno C1-C6Alkyl, Sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxy C1-C6 Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, halo C1-C6Halogenated alkoxy C1-C6Alkane Base, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkyl, halo C1-C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1-C6Alkylamino radical Halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl Base, C1-C6Alkylthiocarbonyl, halo C1-C6Alkylthiocarbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6 Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkylthiocarbonyl C1-C6Alkyl, halo C1-C6Alkylthio group carbonyl Base C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, substitution or Unsubstituted aryloxy group C1-C6Alkyl, substituted or unsubstituted aryloxy group halo C1-C6Alkyl, substituted or unsubstituted aryl amine C1-C6Alkyl, substituted or unsubstituted aryl amine halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, substitution Or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6It is alkyl, substituted or unsubstituted miscellaneous Aryloxy group halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amido C1-C6Alkyl, substituted or unsubstituted heteroaryl amido halo C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl halo C1-C6Alkyl, Substituted or unsubstituted aryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted aryloxycarbonyl halo C1-C6Alkyl, substitution or Unsubstituted aryl amine carbonyl C1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl halides are for C1-C6Alkyl, substitution or unsubstituted Heteroarylcarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroarylcarbonyl halo C1-C6Alkyl, substituted or unsubstituted heteroaryl Epoxide carbonyl C1-C6Alkyl, substituted or unsubstituted Heteroaryloxycarbonyl halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amine Base carbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl amino-carbonyl halo C1-C6Alkyl, substituted or unsubstituted aryl carbonyl Base, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted aryl amine carbonyl, substituted or unsubstituted aryl amine are thio Carbonyl, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted Heteroaryloxycarbonyl, substituted or unsubstituted heteroaryl amine Base carbonyl, substituted or unsubstituted heteroaryl amido thiocarbonyl, substituted or unsubstituted aryl C1-C6Alkoxy C1-C6Alkyl, Substituted or unsubstituted heteroaryl C1-C6Alkoxy C1-C6Alkyl；
R2,R3It may be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkyl, C2- C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkane Epoxide, halo C1-C6Alkoxy, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, two (C1-C6Alkyl) amido, C1-C6Alkyl (halo C1-C6Alkyl) amido, C1-C6Alkyl-carbonyl amido, halo C1-C6Alkyl-carbonyl amido, C1-C6Alkoxy carbonyl amine Base, halo C1-C6Alkoxycarbonylamino, C1-C6Alkyl sulphinyl amido, halo C1-C6Alkyl sulphinyl amido, C1-C6 Alkyl sulphonyl amido, halo C1-C6Alkyl sulphonyl amido, C1-C6Alkyl-carbonyl (C1-C6Alkyl) amido, halo C1-C6Alkane Base carbonyl (C1-C6Alkyl) amido, C1-C6Alkoxy carbonyl (C1-C6Alkyl) amido, halo C1-C6Alkoxy carbonyl (C1-C6Alkane Base) amido, C1-C6Alkyl sulphinyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphinyl (C1-C6Alkyl) amido, C1-C6Alkyl sulphonyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphonyl (C1-C6Alkyl) amido, C1-C6Alkylthio group, halogen For C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulphonyl Base, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkanamine Base carbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkane Base carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl Carbonyl C1-C6Alkoxy, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxy Carbonyl C1-C6Alkoxy, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy, amino unsubstituted or by following substituent group C1-C6Alkyl, aryl, aryloxy group, aryl C1-C6Alkyl, aryl C1-C6Alkoxy, heteroaryl, heteroaryl C1-C6Alkyl, heteroaryl Base C1-C6Alkoxy：Halogen, cyano group, nitro, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1-C6Alcoxyl Base, C1-C6Alkylthio group or C1-C6Alkyl-carbonyl；
R4Selected from H, halogen, CN, CONH2、CSNH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkanes Base, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C2-C6Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano halo C1- C6Alkyl, cyano group C1-C6Alkoxy, cyano halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl amido, halo C1-C6Alkyl sulfinyl amido, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6Alkane Base, C1-C6Alkyl sulfinyl amido C1-C6Alkyl, halo C1-C6Alkyl sulfinyl amido C1-C6Alkyl, C1-C6Alkane sulfonyl oxygen Base, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl amido, halo C1-C6Alkane sulfonyl amido, C1-C6Alkane sulfonyl oxygen Base C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl amido C1-C6Alkyl, halo C1-C6Alkane Sulfonyl amido C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkane Epoxide carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy carbonyl C1-C6Alkoxy, halo C1- C6Alkoxy carbonyl C1-C6Alkoxy, C1-C6Alkylaminocarbonyl C1-C6Alkoxy, halo C1-C6Alkylaminocarbonyl C1-C6Alcoxyl Base, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkane Base, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkane Base, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkoxy, substituted or unsubstituted aryl C1-C6 Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxy, substitution do not take The aryl halide in generation is for C1-C6Alkoxy, substituted or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxy, substituted or unsubstituted heteroaryl halo C1-C6Alkoxy；
R5,R6It may be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, Halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6 Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkyl amino, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6Alkyl amino-carbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkoxy, halo C1-C6Alcoxyl Base C1-C6Alkoxy, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl Base C1-C6Alkoxy, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl Carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkoxy；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Alkenyl, C2-C6Alkynyl, each of which is optionally one or more Following substituent substitution：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1-C6Alkane Epoxide, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulphonyl Base, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan are miscellaneous Aromatic ring；Phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan of hetero-aromatic rings each optionally independent are selected from following substituent by 1 to 3 Substitution：C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, halogen, CN, NO2、C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkylthio group, C1-C6 Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl amino, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6(alkyl) (cycloalkyl) amino, C1-C6Alkyl-carbonyl, C1-C6Alcoxyl Base carbonyl, C1-C6Alkyl amino-carbonyl, C2-C8Dialkyl amino carbonyl；C1-C6Alkoxy；C1-C6Alkyl amino；C2-C6Dioxane Base amino；C3-C8Cycloalkyl amino；C1-C6Alkyl-carbonyl or C1-C6Alkoxy carbonyl；
R8Selected from H, OH, NH2、C(CH3)2CH2S(O)(NH)CH3、C(CH3)2CH2S(O)(NCN)CH3、C1-C6Alkyl, halo C1- C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C3-C8 Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, C3-C8Oxacycloalkyl, C3-C8Oxacycloalkyl C1-C6Alkane Base, hydroxyl C1-C6Alkyl, C1-C6Alkyl amine group C1-C6Alkyl, two (C1-C6Alkyl) amido C1-C6Alkyl, substitution or unsubstituted Pyridine radicals C1-C6Alkyl, substituted or unsubstituted thiazolyl C1-C6Alkyl, substituted or unsubstituted pyridine epoxide C1-C6Alkane Base, substituted or unsubstituted pyridine thio C1-C6Alkyl, substituted or unsubstituted pyridine amido C1-C6Alkyl, substitution do not take The morpholine base in generation, substitution or or unsubstituted piperazinyl, morpholine base C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6 Alkyl sulfoxide base C1-C6Alkyl, C1-C6Alkyl sulfuryl C1-C6Alkyl, C1-C6Alkyl carbonyl epoxide, C1-C6Alkoxy carbonyl oxygen Base, C1-C6Alkylaminocarbonyl epoxide, C1-C6Alkyl sulphonyl epoxide, halo C1-C6Alkyl sulphonyl epoxide, C1-C6Alkyl sulfonyl Amido, halo C1-C6Alkylsulfonamido, substituted or unsubstituted aryl carbonyl epoxide, substituted or unsubstituted aryloxycarbonyl It is epoxide, substituted or unsubstituted aryl amine carbonyl epoxide, substituted or unsubstituted Heteroarylcarbonyl epoxide, substituted or unsubstituted Heteroaryloxycarbonyl epoxide, substituted or unsubstituted heteroaryl amino-carbonyl epoxide, C1-C6Alkylamino radical thiocarbonyl epoxide, substitution or Unsubstituted aryl amine thiocarbonyl epoxide, substituted or unsubstituted aryl C1-C6Alkoxy, substituted or unsubstituted pyridine radicals C1-C6Alkoxy, substituted or unsubstituted thiazolyl C1-C6Alkoxy, C1-C6Alkyl-carbonyl amido, C1-C6Alkoxy carbonyl amine Base, C1-C6Alkylaminocarbonyl amido, C1-C6Alkylamino radical thiocarbonyl amido, substituted or unsubstituted aryl carbonyl amido, substitution Or unsubstituted aryloxycarbonyl amido, substituted or unsubstituted aryl amine carbonylamino, substituted or unsubstituted aryl amine sulphur For carbonylamino, substituted or unsubstituted Heteroarylcarbonyl amido, substituted or unsubstituted Heteroaryloxycarbonyl amido, substitution or Unsubstituted heteroaryl amino-carbonyl amido, substituted or unsubstituted heteroaryl amido thiocarbonyl amido, amino carbonyl amido, C1-C6 Alkylamino radical, two (C1-C6) alkylamino radical, substituted or unsubstituted aryl C1-C6Alkylamino radical, substituted or unsubstituted pyridine radicals C1-C6 Alkylamino radical, substituted or unsubstituted thiazolyl C1-C6Alkylamino radical, N (t-Bu) (COPh), N=CHN (CH3)2, N=C (CH3)2、N =CHCF3, N=CHPh, N=CH (2-Py), N=CH (3-Py), N=CH (4-Py)；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1- C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylamino radical carbonyl Base, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6 Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkanamine Base carbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl, substitution do not take The aryloxycarbonyl in generation, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted Heteroaryloxycarbonyl, substitution do not take The aryl amine carbonyl in generation, substituted or unsubstituted aryl amine thiocarbonyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkane sulfenyl Base, C1-C6Alcoxyl sulfinyl, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6 Alcoxyl sulfonyl, halo C1-C6Alcoxyl sulfonyl.
2. compound according to claim 1, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2、NH2Or NHCH3；
X is selected from H, halogen, CN, NO2、NH2, CHO, CH=NOCH3, CH=NNHCH3Or CH=NN (CH3)2；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from halogen, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, oxa- C2-C8Cycloalkyl, azepine C2-C8Cycloalkyl, thia C2-C8Cycloalkyl, C2-C6 Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl C1-C6Alkyl, halo C1-C6Alkane is sub- Sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfinyl C1-C6Alkyl, halo C1-C6Alcoxyl sulfinyl C1-C6Alkyl, C1-C6Alkane Sulfonyl C1-C6Alkyl, halo C1-C6Alkane sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfonyl C1-C6Alkyl, halo C1-C6Alcoxyl Sulfonyl C1-C6Alkyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogeno C1-C6Alkyl, Sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxy C1-C6 Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, halo C1-C6Halogenated alkoxy C1-C6Alkane Base, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkyl, halo C1-C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1-C6Alkylamino radical Halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl Base, C1-C6Alkylthiocarbonyl, halo C1-C6Alkylthiocarbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6 Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkylthiocarbonyl C1-C6Alkyl, halo C1-C6Alkylthio group carbonyl Base C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, substitution or Unsubstituted aryloxy group C1-C6Alkyl, substituted or unsubstituted aryloxy group halo C1-C6Alkyl, substituted or unsubstituted aryl amine C1-C6Alkyl, substituted or unsubstituted aryl amine halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, substitution Or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6It is alkyl, substituted or unsubstituted miscellaneous Aryloxy group halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amido C1-C6Alkyl, substituted or unsubstituted heteroaryl amido halo C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl halo C1-C6Alkyl, Substituted or unsubstituted aryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted aryloxycarbonyl halo C1-C6Alkyl, substitution or Unsubstituted aryl amine carbonyl C1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl halides are for C1-C6Alkyl, substitution or unsubstituted Heteroarylcarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroarylcarbonyl halo C1-C6Alkyl, substituted or unsubstituted heteroaryl Epoxide carbonyl C1-C6Alkyl, substituted or unsubstituted Heteroaryloxycarbonyl halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amine Base carbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl amino-carbonyl halo C1-C6Alkyl, substituted or unsubstituted aryl C1-C6 Alkoxy C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxy C1-C6Alkyl；
R2,R3It may be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkyl, C2- C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkane Epoxide, halo C1-C6Alkoxy, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, two (C1-C6Alkyl) amido, C1-C6Alkyl Carbonylamino, halo C1-C6Alkyl-carbonyl amido, C1-C6Alkoxycarbonylamino, C1-C6Alkyl sulphinyl amido, halo C1-C6Alkyl sulphinyl amido, C1-C6Alkyl sulphonyl amido, halo C1-C6Alkyl sulphonyl amido, C1-C6Alkyl-carbonyl (C1-C6Alkyl) amido, halo C1-C6Alkyl-carbonyl (C1-C6Alkyl) amido, C1-C6Alkoxy carbonyl (C1-C6Alkyl) amido, C1-C6Alkyl sulphinyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphinyl (C1-C6Alkyl) amido, C1-C6Alkyl Sulfonyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphonyl (C1-C6Alkyl) amido, C1-C6Alkylthio group, halo C1-C6Alkane Sulfenyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkane Base carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halogen For C1-C6Alkylaminocarbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6 Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkane Epoxide, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkane Epoxide, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy；
R4Selected from H, halogen, CN, CONH2、CSNH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkanes Base, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C2-C6Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano halo C1- C6Alkyl, cyano group C1-C6Alkoxy, cyano halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl amido, halo C1-C6Alkyl sulfinyl amido, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6Alkane Base, C1-C6Alkyl sulfinyl amido C1-C6Alkyl, halo C1-C6Alkyl sulfinyl amido C1-C6Alkyl, C1-C6Alkane sulfonyl oxygen Base, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl amido, halo C1-C6Alkane sulfonyl amido, C1-C6Alkane sulfonyl oxygen Base C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl amido C1-C6Alkyl, halo C1-C6Alkane Sulfonyl amido C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkane Epoxide carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy carbonyl C1-C6Alkoxy, halo C1- C6Alkoxy carbonyl C1-C6Alkoxy, C1-C6Alkylaminocarbonyl C1-C6Alkoxy, halo C1-C6Alkylaminocarbonyl C1-C6Alcoxyl Base, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkane Base, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkane Base, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkoxy, substituted or unsubstituted aryl C1-C6 Alkyl, substituted or unsubstituted aryl C1-C6Alkoxy, substituted or unsubstituted heteroaryl C1-C6Alkyl, substitution or unsubstituted Heteroaryl C1-C6Alkoxy；
R5,R6It may be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkanes Base, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, halogen For C1-C6Alkoxy, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulphonyl Base, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkyl Amino, C2-C6Dialkyl amido, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkoxy C1- C6Alkoxy, halo C1-C6Alkoxy C1-C6Alkoxy, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkoxy, halo C1-C6Alkoxy carbonyl C1-C6Alkoxy, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxy, halo C1-C6Alkyl-carbonyl C1-C6Alkoxy；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Alkenyl, C2-C6Alkynyl, each of which is optionally one or more Following substituent substitution：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1-C6Alkane Epoxide, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulphonyl Base, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan are miscellaneous Aromatic ring；Phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan of hetero-aromatic rings each optionally independent are selected from following substituent by 1 to 3 Substitution：C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, halogen, CN, NO2、C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkylthio group, C1-C6 Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl amino, C2- C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6(alkyl) (cycloalkyl) amino, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl Base, C1-C6Alkyl amino-carbonyl, C2-C8Dialkyl amino carbonyl；
R8Selected from H, OH, NH2、C(CH3)2CH2S(O)(NH)CH3、C(CH3)2CH2S(O)(NCN)CH3、C1-C6Alkyl, halo C1- C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, C3-C8Oxa- Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, hydroxyl C1-C6Alkyl, C1-C6Alkyl amine group C1-C6Alkyl, two (C1-C6Alkyl) amido C1-C6Alkyl, substituted or unsubstituted pyridine radicals C1-C6Alkyl, substituted or unsubstituted thiazolyl C1-C6 Alkyl, substituted or unsubstituted pyridine epoxide C1-C6Alkyl, substituted or unsubstituted pyridine thio C1-C6Alkyl, substitution or not Substituted pyridine amido C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl sulfoxide base C1-C6Alkyl, C1-C6Alkyl Sulfuryl C1-C6Alkyl, C1-C6Alkyl carbonyl epoxide, C1-C6Alkoxy-carbonyl oxy, C1-C6Alkylaminocarbonyl epoxide, C1-C6Alkane Base sulfonyl epoxide, halo C1-C6Alkyl sulphonyl epoxide, C1-C6Alkylsulfonamido, halo C1-C6Alkylsulfonamido, take Generation or unsubstituted aryl carbonyl epoxide, substituted or unsubstituted aryloxycarbonyl epoxide, substituted or unsubstituted heteroaryl carbonyl Base epoxide, substituted or unsubstituted Heteroaryloxycarbonyl epoxide, C1-C6Alkylamino radical thiocarbonyl epoxide, substituted or unsubstituted virtue Amido thiocarbonyl epoxide, substituted or unsubstituted aryl C1-C6Alkoxy, substituted or unsubstituted pyridine radicals C1-C6Alcoxyl Base, substituted or unsubstituted thiazolyl C1-C6Alkoxy, C1-C6Alkyl-carbonyl amido, C1-C6Alkoxycarbonylamino, C1-C6Alkane Amino-carbonyl amido, C1-C6It is alkylamino radical thiocarbonyl amido, substituted or unsubstituted aryl carbonyl amido, substituted or unsubstituted Aryloxycarbonyl amido, substituted or unsubstituted aryl amine carbonylamino, substituted or unsubstituted aryl amine thiocarbonyl amido, Amino carbonyl amido, C1-C6Alkylamino radical, two (C1-C6) alkylamino radical, substituted or unsubstituted aryl C1-C6Alkylamino radical, substitution or not Substituted pyridine radicals C1-C6Alkylamino radical, substituted or unsubstituted thiazolyl C1-C6Alkylamino radical；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2- C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halogen For C1-C6Alkoxy carbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl Base C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6It is alkyl, substituted or unsubstituted aryl carbonyl, substituted or unsubstituted Aryloxycarbonyl, substituted or unsubstituted Heteroarylcarbonyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane Sulfonyl, halo C1-C6Alkane sulfonyl.
3. compound according to claim 2, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2；
X is selected from H, halogen, CN, NO2、NH2Or CHO；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from halogen, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, oxa- C2-C8Cycloalkyl, azepine C2-C8Cycloalkyl, thia C2-C8Cycloalkyl, C2-C6 Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl C1-C6Alkyl, halo C1-C6Alkane is sub- Sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfinyl C1-C6Alkyl, halo C1-C6Alcoxyl sulfinyl C1-C6Alkyl, C1-C6Alkane Sulfonyl C1-C6Alkyl, halo C1-C6Alkane sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfonyl C1-C6Alkyl, halo C1-C6Alcoxyl Sulfonyl C1-C6Alkyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogeno C1-C6Alkane Base, sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxy C1- C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, halo C1-C6Halogenated alkoxy C1-C6 Alkyl, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkyl, halo C1-C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1-C6Alkylamino radical Halo C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylamino radical carbonyl Base C1-C6Alkyl, C1-C6Alkylthiocarbonyl C1-C6Alkyl, halo C1-C6Alkylthiocarbonyl C1-C6It is alkyl, substituted or unsubstituted Aryl C1-C6Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, substituted or unsubstituted aryloxy group C1-C6Alkyl, take Generation or unsubstituted aryloxy group halo C1-C6Alkyl, substituted or unsubstituted aryl amine C1-C6Alkyl, substituted or unsubstituted virtue Amido halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted heteroaryl halo C1-C6Alkane Base, substituted or unsubstituted heteroaryloxy C1-C6Alkyl, substituted or unsubstituted heteroaryloxy halo C1-C6Alkyl, substitution or Unsubstituted heteroaryl amido C1-C6Alkyl, substituted or unsubstituted heteroaryl amido halo C1-C6Alkyl, substituted or unsubstituted virtue Base C1-C6Alkoxy C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxy C1-C6Alkyl；
R2,R3It may be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkyl, C2- C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkane Epoxide, halo C1-C6Alkoxy, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, two (C1-C6Alkyl) amido, C1-C6Alkyl Carbonylamino, halo C1-C6Alkyl-carbonyl amido, C1-C6Alkoxycarbonylamino, C1-C6Alkyl sulphinyl amido, halo C1-C6Alkyl sulphinyl amido, C1-C6Alkyl sulphonyl amido, halo C1-C6Alkyl sulphonyl amido, halo C1-C6Alkyl Carbonyl (C1-C6Alkyl) amido, halo C1-C6Alkyl sulphinyl (C1-C6Alkyl) amido, C1-C6Alkyl sulphonyl (C1-C6Alkane Base) amido, halo C1-C6Alkyl sulphonyl (C1-C6Alkyl) amido, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkane is sub- Sulfonyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, halo C1- C6Alkyl-carbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl；
R4Selected from H, halogen, CN, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C2-C6Alkene oxygen Base, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, Cyano group C1-C6Alkoxy, cyano halo C1-C6Alkoxy, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl epoxide, Halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, substitution or unsubstituted Heteroaryl C1-C6Alkyl；
R5,R6It may be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, Halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Alkenyl, C2-C6Alkynyl, each of which is optionally one or more Following substituent substitution：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1-C6Alkane Epoxide, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulphonyl Base, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan are miscellaneous Aromatic ring；
R8Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Alkenyl, halo C2- C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, hydroxyl C1-C6Alkyl, Two (C1-C6Alkyl) amido C1-C6Alkyl, C3-C8Oxacycloalkyl C1-C6Alkyl, substituted or unsubstituted pyridine radicals C1-C6Alkane Base, substituted or unsubstituted thiazolyl C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl sulfoxide base C1-C6Alkyl, C1-C6Alkyl sulfuryl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxy, substituted or unsubstituted pyridine radicals C1-C6Alkane Epoxide, substituted or unsubstituted thiazolyl C1-C6Alkoxy；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl Base, halo C1-C6Alkoxy carbonyl, the substituted or unsubstituted Heteroarylcarbonyl of substituted or unsubstituted aryl carbonyl, C1-C6Alkane Sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl.
4. compound according to claim 3, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H or CN；
X is selected from H, halogen or CN；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from halogen, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, oxa- C2-C8Cycloalkyl, azepine C2-C8Cycloalkyl, thia C2-C8Cycloalkyl, C2-C6 Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl C1-C6Alkyl, halo C1-C6Alkane is sub- Sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfinyl C1-C6Alkyl, halo C1-C6Alcoxyl sulfinyl C1-C6Alkyl, C1-C6Alkane Sulfonyl C1-C6Alkyl, halo C1-C6Alkane sulfonyl C1-C6Alkyl, C1-C6Alcoxyl sulfonyl C1-C6Alkyl, halo C1-C6Alcoxyl Sulfonyl C1-C6Alkyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogeno C1-C6Alkyl, Sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxy C1-C6 Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, halo C1-C6Halogenated alkoxy C1-C6Alkane Base, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkyl, halo C1- C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1-C6Alkylamino radical halogen For C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, substitution or Unsubstituted aryloxy group C1-C6Alkyl, substituted or unsubstituted aryloxy group halo C1-C6Alkyl, substituted or unsubstituted aryl amine C1-C6Alkyl, substituted or unsubstituted aryl amine halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, substitution Or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6It is alkyl, substituted or unsubstituted miscellaneous Aryloxy group halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amido C1-C6Alkyl, substituted or unsubstituted heteroaryl amido halo C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxy C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxy C1-C6Alkyl；
R2,R3It may be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkyl, C2- C6Alkenyl, halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxy, halo C1-C6Alkoxy, C1-C6Alkane Sulfenyl, halo C1-C6Alkylthio group, two (C1-C6Alkyl) amido, C1-C6Alkyl-carbonyl amido, halo C1-C6Alkyl-carbonyl amido, C1-C6Alkoxycarbonylamino, C1-C6Alkyl sulphinyl amido, halo C1-C6Alkyl sulphinyl amido, C1-C6Alkyl sulphur Acyl group amido, halo C1-C6Alkyl sulphonyl amido；
R4Selected from H, halogen, CN, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy, halo C1-C6Alkoxy, cyano group C1- C6Alkyl, cyano group C1-C6Alkoxy, cyano halo C1-C6Alkoxy, C1-C6Alkane sulfonyl epoxide, halo C1-C6Alkane sulfonyl oxygen Base, C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkoxy carbonyl, take Generation or unsubstituted heteroaryl C1-C6Alkyl；
R5,R6It may be the same or different, be respectively selected from H, halogen, CN, CF3Or NO2；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Alkenyl, C2-C6Alkynyl；
R8Selected from H,C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C3-C8Cycloalkyl, C (CH3)2CH2SCH3、CH2CH2CH2N(CH3)2、CH(CH3)CH2OH、
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl Base or halo C1-C6Alkoxy carbonyl.
5. compound according to claim 4, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NH；
X is selected from H, F, Cl, Br, I, CN；
Z is selected from N or CRd；Rd=H, F, Cl, Br；
R1Selected from F, Cl, Br, I, CN, NO2、NH2、CHO、Si(CH3)3、P(CH3)2、P(O)(CH3)2、CH3、CH2CH3、CH (CH3)2、CF3、CF2H、CF2CF2H、CH2CF3、CF2CF3, cyclopropyl,CH=CH2、CH2- CH= CH2、CH2CH=CHCl, C ≡ CH, CH2-C≡CH、CH2C≡CI、CH2S(O)CH3、CH2S(O)CF3、CH2S(O)2CH3、CH2S (O)2CF3、CH2CN、CH2CH2CN、CH2OCH3、CH2CH2OCH3、CH2OCF3、CH2OCF2H、CH2OCF2CF2H、CH2OCH2CF3、 CH2OCF2CF3、CH2SCH3、CH2CH2SCH3、CH2SCF3、CH2SCF2H、CH2SCF2CF2H、CH2SCH2CF3、CH2SCF2CF3、 CH2NHCH3、CH2NHCF3、CH2NHCF2H、CH2NHCF2CF2H、CH2NHCH2CF3、CH2NHCF2CF3、CF2NHCH3、CH2Ph、 CH2OPh、CH2NHPh、 CH2OCH2Ph、 CH2OCH2Py、
R2,R3It may be the same or different, be respectively selected from H, F, Cl, Br, I, CN, C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Alkenyl, Halo C2-C6Alkenyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl amido, halo C1-C6Alkyl-carbonyl amido, C1- C6Alkoxycarbonylamino, halo C1-C6Alkyl sulphinyl amido, halo C1-C6Alkyl sulphonyl amido；
R4Selected from H, F, Cl, Br, I, CN, C1-C3Alkoxy, halo C1-C3Alkoxy, cyano group C1-C3Alkyl, cyano group C1-C3Alcoxyl Base, substituted or unsubstituted heteroaryl C1-C6Alkyl；
R5,R6It may be the same or different, be respectively selected from H, F, Cl, Br, I, CN, CF3、NO2；
R7Selected from H, C1-C6Alkyl；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C(CH3)2CH2SCH3、CH2CH2Cl、CH2CH2Br, cyclopropyl, CH2CH2CH2N(CH3)2、CH(CH3) CH2OH、
R9Selected from H or C1-C6Alkyl.
6. compound according to claim 5, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O or S；
X is selected from H, F, Cl or CN；
Z is selected from N or CRd；Rd=H, F or Cl；
R1Selected from F, Cl, Br, I, CN, NO2、NH2、CHO、Si(CH3)3、CH3、CF3、CF2H、CH2CF3、CF2CF3, cyclopropyl,CH2C≡CI、CH2S(O)CH3、CH2S(O)CF3、CH2S(O)2CH3、CH2S(O)2CF3、CH2CN、CH2CH2CN、CH2OCH3、 CH2OCF3、CH2OCF2CF2H、CH2OCH2CF3、CH2SCH3、CH2SCF3、CH2NHCH3、CH2NHCF3、CH2Ph、CH2OPh、CH2NHPh、 CH2OCH2Ph、
R2,R3It may be the same or different, be respectively selected from H, F, Cl, Br, CN, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、CH2F、 CF2H、CF3、CH2Cl、CCl2H、CCl3、CFClH、NHCOCH3、NHCOCF3、NHC(O)OCH3、NHSOCF3、NHSO2CF3；
R4Selected from F, Cl, Br, CN, OCH3、OCH2CH3、OCF3、OCHF2、OCH2F、OCCl3、OCHCl2、OCH2Cl、OCHFCl、 OCF2CF2H、OCH2CF3、CH2CN、OCH2CN、
R5,R6It may be the same or different, be respectively selected from H, F, Cl, Br, CF3、CN；
R7Selected from H, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、C(CH3)3；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C(CH3)2CH2SCH3、CH2CH2Cl、CH2CH2Br, cyclopropyl, CH2CH2CH2N(CH3)2、CH(CH3) CH2OH、
R9Selected from H or CH3。
7. compound according to claim 6, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O or S；
X is selected from H, F, Cl or CN；
Z is selected from N or CRd；Rd=H, F or Cl；
R1Selected from F, Cl, Br, I, CN, NO2、NH2、CHO、Si(CH3)3、CH3、CF3、CF2H、CH2CF3、CF2CF3, cyclopropyl,CH2S(O)CF3、CH2S(O)2CF3、CH2CN、CH2CH2CN、CH2OCH3、CH2OCF3、 CH2OCF2CF2H、CH2OCH2CF3、CH2SCH3、CH2SCF3、CH2Ph、CH2OPh、 CH2OCH2Ph、
R2,R3It may be the same or different, be respectively selected from H, F, Cl, Br, CN, CH3、CH2CH3、CH(CH3)2、CH2F、CF2H、CF3、 CFClH、NHCOCH3、NHCOCF3、NHC(O)OCH3、NHSOCF3、NHSO2CF3；
R4Selected from F, Cl, Br, CN, OCH3、OCH2CH3、OCF3、OCHF2、OCH2F、OCHFCl、OCF2CF2H、OCH2CF3、CH2CN、 OCH2CN、
R5,R6It may be the same or different, be respectively selected from H, F, Cl, Br, CF3、CN；
R7Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C(CH3)2CH2SCH3, cyclopropyl,
R9Selected from H or CH3。
8. a kind of compound of Formula I as claimed in claim 1 agricultural or other field in as insecticide application.
9. a kind of Pesticidal combination, compound of Formula I as claimed in claim 1 and at least one comprising biology effective dose Annexing ingredient selected from surfactant, solid diluent or liquid diluent.
10. a kind of desinsection, bactericidal composition, it is characterised in that：Contain compound of Formula I as claimed in claim 1 and agricultural The weight percentage of active component is 0.1-99% in upper acceptable carrier, composition.
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