CN105012873A

CN105012873A - Health-care blood-fat-lowering evening primrose oral liquid and preparation method thereof

Info

Publication number: CN105012873A
Application number: CN201510430210.9A
Authority: CN
Inventors: 张卫华
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2015-07-21
Filing date: 2015-07-21
Publication date: 2015-11-04

Abstract

The invention discloses health-care blood-fat-lowering evening primrose oral liquid. The oral liquid comprises, by weight, 10-50 parts of evening primrose, 10-20 parts of radix trichosanthis, 10-20 parts of hawthorn fruit, 10-20 parts of lycium bark, 10-20 parts of radix curcuma, 10-20 parts of safflower carthamus, 10-20 parts of rhizoma chuanxiong, 10-20 parts of dried radix rehmanniae, 10-20 parts of glossy privet fruit, 10-20 parts of giant knotweed rhizome, 10-20 parts of tuber fleeceflower stems, 10-20 parts of fiveleaf gynostemma herbs, 10-20 parts of semen cassiae, 10-20 parts of poria cocos, 10-20 parts of red peony roots, 10-20 parts of capillary wormwood herbs, 10-20 parts of roots of red-rooted salvia, 10-20 parts of rhizoma alismatis, 10-20 parts of pseudo-ginseng and 10-20 parts of corn stigmas. Evening primrose seeds contain 20-30% of oil which contains 70% of linoleic acid and 8-9% of essential gamma-linolenic acid of a human body. Evening primrose oil is capable of treating multiple kinds of diseases, regulating lipid materials in blood and effectively treating diseases such as coronary arterial infarction, atherosclerosis and cerebral thrombosis caused by high cholesterol and hyperlipoidemia, and can be used for treating multiple kinds of scleroses, diabetes, obesity, rheumatic arthritis, schizophrenia and the like.

Description

Radix Oenotherae erythrosepalae health care oral liquid of a kind of blood fat reducing and preparation method thereof

Technical field

The present invention relates to the medical health product containing deriving from plant, animal or raw mineral materials, Radix Oenotherae erythrosepalae health care oral liquid of particularly a kind of blood fat reducing and preparation method thereof.

Background technology

Radix Oenotherae erythrosepalae oil is the most important nutrient drug found this century.Seed oil-containing 20 ~ 30%, in oil, 70% is linoleic acid, and 8 ~ 9% is the gamma-Linolenic acid of needed by human.Radix Oenotherae erythrosepalae oil can treat various diseases, regulate lipid material in blood, the diseases such as the coronary ligation caused hypercholesterolemia, hyperlipidemia, atherosis and cerebral thrombosis have significant curative effect, also can treat multiple sclerosis, diabetes, obesity, rheumatic arthritis and schizophrenia etc., in laboratory, also find the effect that it has anticancer to grow.Utilize the anti-cardiovascular blockage of Radix Oenotherae erythrosepalae oil energy clinically, reduce this characteristic of cholesterol, make specific medicament, for prevention and cure of cardiovascular disease.

Radix Oenotherae erythrosepalae oil contains a large amount of essential fatty acid-γ-linoleic acid (GLA), and its specific activity linoleic acid is high tens times, and the disease utilizing Radix Oenotherae erythrosepalae the earliest to treat is multiple sclerosis, atopic dermatitis, rheumatic arthritis.Radix Oenotherae erythrosepalae originates in America one band, Indians have just found the medical value of Radix Oenotherae erythrosepalae before centuries, the Radix Oenotherae erythrosepalae of whole is soaked in a tepid bath, makes the plaster treatment bruise of lake shape and also it spread on wound and the dermatitis that skin surface is used for treating skin.Seed is entrained to Britain by the ship of carrying Cotton Gossypii by time ability to 18th century in the lump, also be that Europe just starts effect of Radix Oenotherae erythrosepalae to develop at this moment, many scientists, doctor drop into the research of Radix Oenotherae erythrosepalae one after another, and for multiple sclerosis, atopic dermatitis, rheumatic arthritis treatment.

Two large magical composition Radix Oenotherae erythrosepalaes of Radix Oenotherae erythrosepalae contain a large amount of necessary fatty acids and GLA: γ-linoleic acid, and Radix Oenotherae erythrosepalae of wanting to know-why has so important medical health care to be worth, and just must be familiar with these two kinds of compositions to the impact of human body.So-called " must fatty acid ", be exactly extremely important to human body, but cannot synthesizes voluntarily, must from the material of external world's picked-up, and its effect in vivo has: provide energy, maintain body temperature, protective tissue and organ; The most important thing is, it is the indispensable material of composition cells in vivo and tissue, is also the material that human body uses the important prostaglandin of synthesis and hormone, can thinks and see, if lack " necessary fatty acid ", human body can face: alopecia, and wound not easily heals.Have a strong impact on reproductive function.Immunologic function reduces, and the probability that health infects by virus and bacteria increases.

Common people naturally absorb " necessary fatty acid " from milk, vegetable seeds wet goods food, but in recent years because in the dietary sources of modern and dietary habit, undue picked-up three-hypers food: " hypercholesterolemia, higher fatty acid, high sugar content ", the source of these foods not still not nutrition, also can hinder the absorption of health to normal " necessary fatty acid ", what is called " nutrition is exaggerated " that Here it is equals the example of " malnutrition ".

In the composition of Radix Oenotherae erythrosepalae, be mainly the linoleic acid of 70%, the γ-linoleic acid of 9%, two primary categories of these two kinds " must fatty acid " just, this also explains the rationale that why Radix Oenotherae erythrosepalae is so important to human body.

In the composition of Radix Oenotherae erythrosepalae, another composition being classified as the research of medical circle focus is prostaglandin (prostagland).Nineteen thirty, the scientist of a Switzerland found this material in seminal fluid, and called after " prostaglandin ", Hou just finds prostaglandin ubiquity in human body, and has multiple different combination, and plays the synergism in different human bodies.Cite an actual example and just can know that Radix Oenotherae erythrosepalae has played the power of influence of what mystery here: the world of medicine likes being used as antiinflammatory and the formula organizing antiallergic with steroid, steroid also can reach this effect really fast, just not only side effect is large for steroid, and concerning human body, steroid suppresses " inflammatory prostaglandin " and " anti-inflammatory prostaglandin " simultaneously; The characteristic of Radix Oenotherae erythrosepalae is exactly: it can synthesize and increases " anti-inflammatory prostaglandin " but can suppress " inflammatory prostaglandin ", the biological activity of this uniqueness, makes Radix Oenotherae erythrosepalae become the formula countermeasure of more wisdom, also significantly reduces the possibility of side effect.This explains the large Gospel why Radix Oenotherae erythrosepalae may be allergic constitution patient.

In the classic of TCM of China, then Radix Oenotherae erythrosepalae is made medical herbs, be used for the treatment of in gastro-intestinal problems, asthma, cough, the healing of wound and gynaecological disease, because it is for the subduction pain of women physiological period and the secret of discomfort, just at its γ-linoleic acid be rich in and linoleic acid, energy blood vessel dilating, promotes that blood follows and nurses one's health hormone, alleviate having some setbacks and dysmenorrhoea of menstrual period, even improve climacteric obstacle.

Radix Oenotherae erythrosepalae is also known as primrose because it sees that the moon is bloomed between the lights, and daybreak namely adjust and thank, therefore named Radix Oenotherae erythrosepalae.Radix Oenotherae erythrosepalae oil takes from evening primrose seed, and be rich in GLA (gamma-Linolenic acid), gamma-Linolenic acid is a kind of essential fatty acid, self can not synthesize, must absorb from the external world in human body.It is become one to be similar to the material of hormone (PGE1) by " processing " in human body.The physiological action of gamma-Linolenic acid: endocrine regulation balances, and improves pre-menstrual syndrome, as: alleviate distending pain of the breast, irregular menstrual period, the stomachache soreness of waist etc.; Improve climacteric syndrome, as: anxiety, irritability, insomnia, giddy, perspiration etc.Improve that wrinkle increases, pigmentation, skin are yellow, black, senility and obesity problem in advance, prevent and treat allergic dermatitis.Reduce serum cholesterol and triglyceride level and suppress hematoblastic coagulation in body, preventing thrombosis.Blood vessel dilating, to reduce blood pressure, suppress rheumatoid arthritis etc.

General Radix Oenotherae erythrosepalae oil can, through heavy refining process to purify oil content, therefore, often select more cheap, low-quality or dirty oil for refining.But complicated refining process but destroys oil and a beneficial in eliminating, comprises three notes.Three notes are the natural lipophilic antioxidant contained by Radix Oenotherae erythrosepalae oil, can to free radical resisting, make the leukocyte of human body play better function, and there is antiinflammation, contribute to eliminating arthralgia.

Once eliminate these antioxidants, the oil through refine will become unstable, and is easy to cause oxidation, the toxin of the heating schedule meeting especially in refining process and then generation potentiality and carcinogenecity peroxide.

The better alternative method of producing Radix Oenotherae erythrosepalae oil adopts method for cold pressing.This process be at high pressure but low temperature squeeze the oil content of seed, therefore can guarantee that oil is stable completely, subtract protoxydic risk.

The Radix Oenotherae erythrosepalae oil produced with method for cold pressing at all without the need to through heavy refining process to purify oil content, therefore be called as the Radix Oenotherae erythrosepalae oil that " non-residual liquid " refine.Thus, the beneficial in individual-such as three notes, can be kept in oil content.

Oil content and heat, light can minimize with contacting of oxygen (destroying three large factors of oil) by the production process of cold pressing and the refining of non-residual liquid, therefore its quality can be allowed to remain on the purest native state, a natural components in simultaneously also saving-comprise three notes.

Along with growth in the living standard, the diet of people also there occurs change, and hyperlipidemia has become a kind of very common disease, and the appearance of hyperlipidemia simultaneously can cause more other diseases again, as hypertension etc.Therefore, how blood fat reducing the problem that everybody is concerned about most could have been become.Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, inappetence, hypomnesis, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse grain completely, a large amount of three-hypers (high heat, high protein, higher fatty acid), more than three, (antiseptic is many, flavour enhancer is many, hormone is many) pesticide residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and quantity of motion less than normal, go down to make three-hypers disease (hypertension for a long time like this, hyperglycemia, hyperlipidemia), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind." three-hypers disease " refers to hypertension, hyperglycemia (diabetes) and hyperlipidemia.Usually along with obesity.They be modern society derive from " affluenza ", can individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipidemia simultaneously, and hyperlipidemia is the principal element of arteriosclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three-hypers disease ".Be what has statistics about three-hypers, in the Chinese ten large causes of death, the mortality rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three-hypers " also accounts for 27% of total death toll.Hyperlipidemia can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycemia can cause diabetes.

A lot of diabetes patient is with hyperlipemia, and therefore diabetes and hyperlipemia, people call that sister is sick usually, and think that hyperlipidemia is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglyceride increases to reduce with high density lipoprotein.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglyceride and FFA concentrations in blood are increased.Type 2 diabetes mellitus people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's hyperlipidemia person, because Insulin receptor INSR number reduces relatively, thus produce insulin resistant, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.

Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of Radix Oenotherae erythrosepalae not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.

Summary of the invention

Technical problem to be solved by this invention is, current doctor trained in Western medicine has obtained larger achievement to the research of diabetic hyperlipidemia and treatment, but the hepatic and renal function caused by long-term prescription, symptom of digestive tract, after muscle damage and drug withdrawal, rebound effect is still a difficult problem for treatment.In view of the traditional Chinese medical science has the characteristic of dialectical treatmert, the advantage that Chinese medicine toxic side effect is little, Chinese medicine health-care treatment causes extensive concern.Chinese medicine also exists dual regulation, when central concentration is too high, may causes certain antagonism, and make drug effect influenced; During low dosage, possible drug level is too low, causes drug effect and does not show.And it is not good to take mouthfeel, medicine is poor, very inconvenient.Radix Oenotherae erythrosepalae oil is the most important nutrient drug found this century.Seed oil-containing 20 ~ 30%, in oil, 70% is linoleic acid, and 8 ~ 9% is the gamma-Linolenic acid of needed by human.Radix Oenotherae erythrosepalae oil can treat various diseases, regulate lipid material in blood, the diseases such as the coronary ligation caused hypercholesterolemia, hyperlipidemia, atherosis and cerebral thrombosis have significant curative effect, also can treat multiple sclerosis, diabetes, obesity, rheumatic arthritis and schizophrenia etc., in laboratory, also find the effect that it has anticancer to grow.Utilize the anti-cardiovascular blockage of Radix Oenotherae erythrosepalae oil energy clinically, reduce this characteristic of cholesterol, make specific medicament, for prevention and cure of cardiovascular disease.

For solving the problems of the technologies described above, the invention provides a kind of Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing, it is characterized in that, the parts by weight of described health care oral liquid crude drug are: Radix Oenotherae erythrosepalae 10 ~ 50 parts, Radix Trichosanthis 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Cortex Lycii 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, 10 ~ 20 parts, Flos Carthami, Rhizoma Chuanxiong 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Semen Cassiae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Alismatis 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts.

The Radix Oenotherae erythrosepalae health care oral liquid of described blood fat reducing, the parts by weight of health care oral liquid crude drug described in it can be: Radix Oenotherae erythrosepalae 10 ~ 30 parts, Radix Trichosanthis 10 ~ 15 parts, Fructus Crataegi 10 ~ 15 parts, Cortex Lycii 10 ~ 15 parts, 10 ~ 15 parts, Rhizoma Curcumae Longae, 10 ~ 15 parts, Flos Carthami, Rhizoma Chuanxiong 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Semen Cassiae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Alismatis 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts.

The Radix Oenotherae erythrosepalae health care oral liquid of described blood fat reducing, the parts by weight of health care oral liquid crude drug described in it can also be: Radix Oenotherae erythrosepalae 10 ~ 40 parts, Radix Trichosanthis 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Cortex Lycii 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, 10 ~ 20 parts, Flos Carthami, Rhizoma Chuanxiong 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Semen Cassiae 10 ~ 15 parts, 10 ~ 15 parts, Poria, Radix Paeoniae Rubra 10 ~ 15 parts, Herba Artemisiae Scopariae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Alismatis 10 ~ 15 parts, Radix Notoginseng 10 ~ 15 parts, Stigma Maydis 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing, and described in it, the preparation process of Chinese medicine health-care oral liquid comprises:

A. the extraction of evening primrose seed, as component 1;

B. all the other crude drug described are put into ethanol heating and refluxing extraction 2 times, as component 2 after concentrated;

C. by add after appropriate pharmaceutical grade methylcellulose in component 1 and component also 2-in-1, add dextrin and be in harmonious proportion, after disinfection, be prepared into health oral liquor.

In described step a, can Maturity be chosen high, without insect pest, without rotting, the evening primrose seed of no-sundries; Adopt cryogenic high pressure cold pressing process, namely adopt pure physical squeezing technique, overall process is all carried out under low temperature 35 DEG C of states, collects, the Radix Oenotherae erythrosepalae oil after cold pressing as component 1.

In described step b, the medicine of all the other crude drug can be put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.05 filtrate.

In described step b, may further include and the filtrate of extraction concentrated, inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, becomes component 2.

In described step c, the Radix Oenotherae erythrosepalae of component 1 can be extracted oil and add appropriate pharmaceutical grade methylcellulose, blending ingredients 2, stir and add dextrin mediation, bottle after ultraviolet ray sterilization bactericidal.

For solving the problems of the technologies described above, the present invention reoffers a kind of Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing, and its preparation process can also be:

A. the high pressure low temperature cold pressing preparation of evening primrose seed, as component 1;

B. all the other crude drug described soaked, extract 3 times as component 2;

C. component 1 is added appropriate pharmaceutical grade methylcellulose and component 2 mixes, add appropriate propolis after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step b, all the other crude drug can be soaked in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2.

Radix Oenotherae erythrosepalae oil is the most important nutrient drug found this century.Seed oil-containing 20 ~ 30%, in oil, 70% is linoleic acid, and 8 ~ 9% is the gamma-Linolenic acid of needed by human.Radix Oenotherae erythrosepalae oil can treat various diseases, regulate lipid material in blood, the diseases such as the coronary ligation caused hypercholesterolemia, hyperlipidemia, atherosis and cerebral thrombosis have significant curative effect, also can treat multiple sclerosis, diabetes, obesity, rheumatic arthritis and schizophrenia etc., in laboratory, also find the effect that it has anticancer to grow.Utilize the anti-cardiovascular blockage of Radix Oenotherae erythrosepalae oil energy clinically, reduce this characteristic of cholesterol, make specific medicament, for prevention and cure of cardiovascular disease.Decoction is the conventional dosage forms of the traditional Chinese medical science, and it is convenient with advantages such as disease plus-minuss to have, but decoction decocting, carries, uses inconvenience, and composition is not exclusively fried, and mouthfeel is poor, is not suitable for the Modern human populations medication custom.Because the present invention is mainly used in preventing and treating hyperlipemia, hyperglycemia, this disease belongs to multifactor relevant chronic disease, and the course of disease is longer, needs long-term prescription just can reach good effect, therefore should select to take, carries, easy to usely more can improve health-care effect.Add some blood circulation promoting and blood stasis dispelling, fat and serum triglycerides are all had to the Chinese crude drug of obvious reducing effect, and can microcirculation be improved, the most mouthfeel of these medical materials is light, do not affect the taste of Radix Oenotherae erythrosepalae, make people be easy to accept, more can reach effect of blood fat reducing preferably.

Detailed description of the invention

In the blood of people, lipid contained in blood plasma is called blood fat, comprise cholesterol, cholesterol ester, triglyceride, phospholipid and not esterified fat acid etc. several.When cholesterol, triglyceride etc. all exceed normal value, be then referred to as hyperlipemia.Hyperlipemia is atherosclerotic Main Etiological Factors.Often cause serious consequence, as coronary heart disease, diabetes, cerebrovas-cularaccident, intractable hypertension and the nephrotic syndrome, pancreatitis, calculosis, fatty liver etc. because invading vitals.Arteriosclerotic generation and development, have close relationship with Hyperlipemia.Health preserving guide: one. reasonable diet is taken good care of: human body lipid comprises fat and lipoid two kinds.The relation of hyperlipemia and diet is the closest.Body fat gather the source with part lipoid, mainly from diet.Only some lipoid synthesizes in vivo, is called endogenous lipoid.It is very important for keeping on a diet to the control of hyperlipemia.Diet is advocated light, is substantially a vegetarian.But should not be a vegetarian for a long time, otherwise dietary constituents imperfection, endogenous cholesterol can be caused on the contrary to increase.Higher fatty acid, hypercholesterolemia class diet should be limited, as animal brains, egg yolk, Hepar Gallus domesticus, butter etc.Fat intake is limited in 30 ~ 50 grams every day.Carbohydrate food also will limit, and does not eat sweet food and snacks.Eat vegetable and fruit more.Suitable low salt diet, edible oil should use Oleum Glycines, Oleum Arachidis hypogaeae semen, vegetable oil, Oleum Sesami etc.Hungry full appropriateness, food-intake of often eating have dinner with next meal before half an hour have hunger sensation for degree, should not adopt starvation, excessive hunger makes body fat accelerated decomposition on the contrary, and fat acid in blood is increased.Two. definitely smoking cessation is given up alcohol: the nicotine in medicated cigarette, peripheral vessels can be made to shrink and the increase of myocardium irritability, blood pressure be raised, angina pectoris attacks.Inappropriate drinking can make Heart function fails, all has infringement to gastrointestinal tract, liver, nervous system, hormonal system, definitely should give up smoking and give up alcohol.Three. advocate and drink tea in right amount: the catechuic acid contained in Folium Camelliae sinensis has enhancing blood vessel pliability, elasticity and infiltrative effect, can prevent sclerosis of blood vessels.Theophylline in Folium Camelliae sinensis and caffeine can be excited spiritual, and blood circulation promoting, lessens fatigue and have diuresis.Drink tea in right amount and can eliminate greasy diet and lose weight.But too much drink strong tea, meeting cardiac stimulus, makes palpitating speed, is harmful to health.Four. appropriate exercise is lost weight: obesity controlling is one of important measures of prevention Hyperlipemia.Except diet control, advocate and adhere to physical training, as jogged, five mimic-animal boxing as a physical fitness exercises, taijiquan, play table tennis, disco for the elderly etc.Often participate in manual labor at ordinary times.Control the growth of body weight.

Does which hyperlipemia have endanger to patient? (1) glomerular sclerosis etc.: hyperlipemia can cause vascular endothelial cell damage and stove shape to come off, Vascular Permeability is caused to raise, plasma lipoprotein is entered and is deposited on blood vessel wall inner membrance, thereafter cause the cleaning reaction of macrophage and vascular smooth muscle cell curing and form speckle, and cause arteriosclerosis, renal arteriosclerosis, luminal stenosis, can make kidney generation ischemia, atrophy, interstitial fibers hypertrophy.If Renal vascular blocks, respective regions infarction, forms cicatrix after infarct machine.So cause glomerular sclerosis.Then can accelerate the generation of coronary atherosclerosis at kidney outward, cause coronary heart disease and increase the danger that myocardial infarction occurs patient.Equally, the arteriosclerosis at other positions then causes corresponding disease, as cerebral arteriosclerosis, cerebral infarction etc.(2) glomerular injury: hyperlipemia can cause lipid to deposit in glomerule, low density lipoprotein, LDL can activate mononuclear cell in circulation and cause monocyte infiltration in glomerule, and cause or exacerbate inflammation reaction, simultaneously the mesangial cell of glomerule, endotheliocyte all can produce activating oxygen molecule, promote lipid peroxidation, Oxided low-density lipoprotein (OX-LDL) has extremely strong cytotoxicity, causes Renal tissues damage.In addition, hyperlipemia can also cause collagen in Glomerular mesangium component *, laminin，LN and fibrin to increase, and these compositions are all directly related with glomerular sclerosis.

Does fat-reducing contribute to blood fat reducing? as everyone knows, hyperlipemia and low HDL mass formed by blood stasis are one of the most dangerous factors of arteriosclerosis, and overweight people usually merges lipometabolic exception, and along with the increase of obese degree, and more performance is obviously for hyperlipemia; On the contrary, too high blood fat, also promotes the excessive accumulation of fat simultaneously, forms vicious cycle.Moreover, people also find that the rising of blood fat has close relationship with the distribution of fat.The people such as Ji Saibai etc. (Kissebah, AH) think: " Fat Distribution according to people is classified, and can be divided into has the significant central obesity of soma fat deposit, and the obvious end of extremity slightly property is fat; Also have UBSO that above the waist athero is more and the more LBSO of lower part of the body athero.The disease such as hyperlipemia and diabetes, based on central obesity and UBSO, so take measures energetically to lose weight, contributes to reducing blood fat.Weight-reducing and lipid-lowering should based on composite treatment, comprise and use Chinese medicine dampness removing to reduce phlegm agent, high-fat diet is eaten in restriction, eat vegetable, bean product, lean meat, Carnis Gallus domesticus, Rhopilema esculenta etc. more, eat the more vegetable of cellulose as much as possible more, can reduce the absorption of enteral cholesterol, Bulbus Allii Cepae, Bulbus Allii, Auricularia, Fructus Crataegi, Lentinus Edodes have good effect for reducing fat, and cooking oil is preferably based on vegetable oil.The diet heat of limiting patient, eat sweet food less, add sharp movement, increase consumption, wine for giving off smoking, avoid hypertonicity, life is regular.

In the composition of Radix Oenotherae erythrosepalae, be mainly the linoleic acid of 70%, 9% _γ-linoleic acid, two primary categories of these two kinds " must fatty acid " just, this also explains the rationale that why Radix Oenotherae erythrosepalae is so important to human body.

Fructus Crataegi is containing multivitamin, Crataegolic acid, tartaric acid, citric acid, malic acid etc., and also containing the mineral such as flavonoid, lactone, saccharide, protein, fat and calcium, phosphorus, ferrum, contained lipolytic enzyme can promote the digestion of fat food.Promote gastric secretion and increase the functions such as gastric enzyme element.The traditional Chinese medical science is thought, Fructus Crataegi has that removing food stagnancyization is stagnant, convergence effect such as dysentery relieving, activating blood circulation to dissipate blood stasis.Cure mainly the diseases such as eating accumulation, chest and diaphragm feeling of fullness, the amenorrhea of hernia blood stasis.Containing the ingredient such as mountain terpenoid and pyrite class in Fructus Crataegi, there is significant blood vessel dilating and hypotensive effect, there is the function strengthening cardiac muscle, arrhythmia, adjusting blood lipid and cholesterol level, Fructus Crataegi has effect of activating blood circulation to dissipate blood stasis, contribute to removing local congestion state, have auxiliary curative effect to traumatic injury; Flavonoid contained by Fructus Crataegi and the substance such as vitamin C, carotene block and reduce the generation of free radical, and the immunity of energy enhancing body, has anti-aging, anticancer effect; Having in Fructus Crataegi relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.

Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and be clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, and evacuation of pus is subsided a swelling.Cure mainly: control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For treatment diabetes, conventional it and drugs for nourishing yin with the use of, to reach the effect for the treatment of both the principal and secondary aspects of a disease." book on Chinese herbal medicine converge with speech ": Radix Trichosanthis, it is hot and suffocating to move back the five internal organs, and as heart-fire is contained and dry tongue and mouth, lung-fire is contained and pharyngeal swelling sore throat, and spleen-fire is contained and dispute tooth swells, and phlegm-fire is contained and cough is not peaceful.If the side of body of liver-fire is swollen migratory arthralgia caused by wind, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle is not burst, and pyretic toxicity does not fall apart, or five types of jaundice yellow skin and eye, and if if little water drenches puckery, be caused by all burning hot pent-up, phlegm-fire, falls in only this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control thirsty, and control empty thirsty from tonic, control fire from the medicine of a cold nature thirsty, control yearningly strongly fragrant from gas medicine, controlling excessive thirst from blood medicine, is control thirsty key medicine also.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosaLibosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.Relative to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, all right yin nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat epidemic febrile disease, qingying decoction can be done with the Radix Rehmanniae; If the later stage for the treatment of epidemic febrile disease, because waste heat does not also disappear to the greatest extent, the Radix Rehmanniae should be used for boiling QINGHAOBIEJIATANG; In addition, contain for heat in blood poison, macule purple is black, and the serious heat of epidemic febrile disease enters the symptom of nutrient blood, can take the Sisheng Wan that the Radix Rehmanniae is made; General want YIN nourishing and the production of body fluid promoting to treat interior-heat quenches one's thirst with constipation, the once liquid soup that the Radix Rehmanniae boils should be eaten.

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, and often join the same use of Fructus Mori, fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglyceride accumulation minimizing in liver, hepatocellular degeneration necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultrastructure visible hepatocyte mitochondrial swelling and endosomal vesicle degeneration alleviate, hepatic tissue interstitial inflammation habituation

The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function with cure mainly: heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis does not Xia ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus.Rhizoma Polygoni Cuspidati extract has antipyretic effect.Resveratrol glycoside and pentobarbital sodium and urethanes have synergism, can obvious Sleeping Time Prolong Ed.Huzhang has convergence to scald wound, protects from infection and antiinflammation.In addition, certain density Stigma Maydis element can cause small intestinal hypermyotonia, and contractive amplitude increases, and increased dosage amount then can suppress small intestinal movable.Supplement to the Herbal: main air is between joint and blood stasis.Liquor takes it as wine." Japan hanako materia medica ": after managing property stagnant blood not under, trusted subordinate's distension.Evacuation of pus, main furuncle carbuncle poison, married woman's bruise, flutters damage blood stasis, broken pathogenic wind toxic stagnation of QI." the southern regions of the Yunnan Province book on Chinese herbal medicine ": attack all toxic swellings, only have sore throat, diuresis, walk meridians.Control five types of stranguria nebulousurine, anal fistula, carbuncle sore, married woman's leucorrhea with red and white discharge.

Herb Gynostemmae Pentaphylli finds through modern medicine study, Herb Gynostemmae Pentaphylli principle active component is polysaccharide, flavonoid, saponins and microelement kind, its effect mainly promotes body fat class substance metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (pharyngolaryngitis, gastroenteritis etc.) and health care.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Radix Paeoniae Rubra, clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, suffer from abdominal pain, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.

Caulis Polygoni Multiflori meridian distribution of property and flavor: sweet micro-hardship is flat.Nourish heart, calm the nerves, dredging collateral, dispel the wind, cure mainly: control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.The traditional Chinese medical science is thought, Caulis Polygoni Multiflori is put down nontoxic, sweet and slightly bitter taste, enters the heart, Liver Channel, has effect of tranquilizing and blood nourishing, dispelling wind and removing obstruction in the collateral, cures mainly the diseases such as deficiency of YIN insufficiency of blood, restlessness of asrhenia type and insomnia, rheumatic arthralgia, itchy skin eruption.The decoction dosage of Caulis Polygoni Multiflori is generally 10 ~ 30 grams, also can decoction being used as a lotion or smash deposited external.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are amassed, or skin infection sufferings and swollen burst uneasy, be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on.

Rhizoma Chuanxiong is a kind of Chinese medicinal plant, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, and the pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.

Semen Cassiae, Chinese medicine name.The dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae, have the merit of improving eyesight with it and name it.To gather autumn mature fruit, dry, lay seed, removing impurity.Semen Cassiae bitter in the mouth, sweet, one-tenth, cold nature, enters liver, kidney, large intestine channel; Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, has laxative action, reducing blood pressure and blood fat.

Rhizoma Curcumae Longae Rhizoma Curcumae Longae energy circulation of qi promoting removing blood stasis with potent drugs, inducing menstruation to relieve menalgia.Cure mainly chest and abdomen swelling and pain, shoulder arm arthralgia pain, unbearably pained, puerperal blood pain, skin ulcer tinea onset, menoxenia, amenorrhea, traumatic injury.Yellow food colour can be extracted again; Contained curcumin can perform an analysis chemical reagent.Tang Materia Medica: main trusted subordinate ties long-pending, and chronic infectious disease is disobedient, the therapeutic method to keep the adverse QI flowing downwards, removing blood stasis, except wind heat, subduing inflammation.Power is strong in Radix Curcumae." Japan hanako materia medica ": control lump in the abdomen clot, carbuncle, logical menstruation, controls to fall and flutters blood stasis, detumescence poison; Only storm wind pain cold air, lower food.

Cortex Lycii, another name: Chinese wolfberry skin is Solanaceae, Lycium, is the root bark of Fructus Lycii Lycium chinense Mill..Can be used as medicine, there is removing heat from blood except effects such as steaming, lung heat clearing pathogenic fire reducing.Heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil." herbal classic ": " pathogen in main five, hankers quenching one's thirst, general arthralgia." " not Lu ": " main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and to hiss suction, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat.″

Herba Artemisiae Scopariae is bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.Deng. the effects such as pharmaceutical research has function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, coronary dilating.

Rhizoma Alismatis: be longer than promoting diuresis to eliminate damp pathogen, expels the heat-evil, for dysuria, and edema distension, the puckery pain of stranguria with turbid discharge, seminal emission, foot knee joint flaccidity is soft; Fry Rhizoma Alismatis, be partial to and spleen eliminating dampness by diuresis, for phlegm retention, dysentery, the vertigo.Rhizoma Alismatis, Poria, Polyporus; Three all can seep water dampness removing and inducing diuresis to remove edema, and Chang Sanzhe is with using; Right Rhizoma Alismatis is cold in nature, can expel the heat-evil, clearly mutually fire; Poria then can heart-spleen boosting, tranquilizing mind; And Polyporus, can only eliminating dampness by diuresis diuresis.Sweet in the mouth; Light; Cold in nature, return kidney; Urinary bladder channel.Function cures mainly: promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Main dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission.

Stigma Maydis, also claims maize palpus.Medicinal record the earliest sees 1476 " the southern regions of the Yunnan Province book on Chinese herbal medicine ", and be the traditional Chinese crude drug of China, " Chinese Pharmacopoeia " records for 1977.For " Ministry of Health of the People's Republic of China's medical material standard " 1985 editions medicinal herbs most in use kinds that () includes.Stigma Maydis also known as dragon must be used for soaked drink to health benefit.Dragon must tea " mouthfeel is pretty good, drinks pleasantly sweet, economical and practical again, can do the health tea of the whole family.The patient of hyperlipidemia, hypertension, hyperglycemia has drunk, can blood fat reducing, blood pressure, blood glucose.Summer summer heat weight, dragon must tea effect of having removing heat from blood, purging heat, can remove the damp and hot gas in body.Stigma Maydis decoct has effect for reducing blood fat equally to hyperlipidemia patient, thus plays protection heart and brain, reduces the sickness rate of ischemic cardiovascular (comprising coronary heart disease and cerebral infarction).The lipid metabolism of Maize silk flavones extract to mice has obvious regulating action, and presents obvious dose-effect relationship.Chen Zhiqian Stigma Maydis coordinates certainly black soup treatment dyslipidemia patient 65 example to show, after treatment, TC, LDL-C significantly decline, and compare before and after treatment, difference all has the meaning of highly significant, and its effective percentage reaches 89.2%.Stigma Maydis has expansion peripheral blood vessel and has lasting hypotensive effect, especially the longest to the hypotensive effect persistent period of cold blooded animal, and when Stigma Maydis is with when certainly black soup share, its hypotensive effect greatly strengthens, and action time also extends to some extent." Chinese medicine voluminous dictionary " is recorded, and Popular Utilization Stigma Maydis treatment diabetes achieve good curative effect, and its fermentation preparation has the hypoglycemic activity of highly significant to rabbit.At present, studies in China is more is the blood sugar reducing function of corn silk water extract, Stigma Maydis total saponins and corn silk polysaccharide.

Radix Notoginseng is used as medicine with its root, and it is warm in nature, acrid in the mouth, has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Excavating in season in winter in spring two because being everlasting, being divided into again " spring seven " and " winter seven ".Record in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying the first, Radix Notoginseng enriches blood the first, taste with and merit also etc., therefore claiming Panax pseudoginseng, is the most precious person in Chinese medicine." become famous Chinese patent medicine " YUNNAN BAIYAO " at home and abroad and " Pien Tze Huang ", be namely that primary raw material is made with Radix Notoginseng.Cure mainly spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.

The specific embodiment of the invention

Specific embodiment 1: it is high that autumn chooses Maturity, without insect pest, without rotting, the Radix Oenotherae erythrosepalae fruit of no-sundries; Adopt cryogenic high pressure cold pressing process, namely adopt pure physical squeezing technique, overall process is all carried out under low temperature 35 DEG C of states, collects, the Radix Oenotherae erythrosepalae oil after cold pressing as component 1.

Then by Radix Trichosanthis, Fructus Crataegi, Cortex Lycii, Rhizoma Curcumae Longae, Flos Carthami, Rhizoma Chuanxiong, the Radix Rehmanniae, Fructus Ligustri Lucidi, Rhizoma Polygoni Cuspidati, Caulis Polygoni Multiflori, Herb Gynostemmae Pentaphylli, Semen Cassiae, Poria, Radix Paeoniae Rubra, Herba Artemisiae Scopariae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Radix Notoginseng, Stigma Maydis; Add soak with ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, heating be concentrated into filtrate, stand for standby use.

Filtrate inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount as component 2; Then component 1 is added appropriate pharmaceutical grade methylcellulose and component 2 mixes, add appropriate dextrin after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

Specific embodiment 2: it is high that autumn chooses Maturity, without insect pest, without rotting, the Radix Oenotherae erythrosepalae fruit 1000g of no-sundries; Adopt cryogenic high pressure cold pressing process, namely adopt pure physical squeezing technique, overall process is all carried out under low temperature 35 DEG C of states, and collected by the Radix Oenotherae erythrosepalae oil after cold pressing, general 250g, as component 1.By Radix Trichosanthis 200g, Fructus Crataegi 200g, Cortex Lycii 200g, Rhizoma Curcumae Longae 200g, Flos Carthami 200g, Rhizoma Chuanxiong 200g, Radix Rehmanniae 200g, Fructus Ligustri Lucidi 200g, Rhizoma Polygoni Cuspidati 200g, Caulis Polygoni Multiflori 200g, Herb Gynostemmae Pentaphylli 200g, Semen Cassiae 200g, Poria 200g, Radix Paeoniae Rubra 200g, Herba Artemisiae Scopariae 200g, Radix Salviae Miltiorrhizae 200g, Rhizoma Alismatis 200g, Radix Notoginseng 200g, Stigma Maydis 200g, the medicine of all the other crude drug is put into and accounts for its quality 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, heating is concentrated into filtrate, stand for standby use, inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, sets to 0 ~ 5 DEG C of deepfreezes 24 hours, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, then component 1 is added pharmaceutical grade methylcellulose and component 2 mixes, add appropriate propolis after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal of bottling after ultraviolet ray sterilization bactericidal.

Specific embodiment 3: it is high that autumn chooses Maturity, without insect pest, without rotting, the Radix Oenotherae erythrosepalae fruit 1500g of no-sundries; Adopt cryogenic high pressure cold pressing process, namely adopt pure physical squeezing technique, overall process is all carried out under low temperature 35 DEG C of states, and collected by the Radix Oenotherae erythrosepalae oil after cold pressing, general 350g, as component 1 stand for standby use.By all the other crude drug Radix Trichosanthis 300g, Fructus Crataegi 400g, Cortex Lycii 300g, Rhizoma Curcumae Longae 400g, Flos Carthami 500g, Rhizoma Chuanxiong 500g, Radix Rehmanniae 300g, Fructus Ligustri Lucidi 400g, Rhizoma Polygoni Cuspidati 400g, Caulis Polygoni Multiflori 300g, Herb Gynostemmae Pentaphylli 300g, Semen Cassiae 400g, Poria 300g, Radix Paeoniae Rubra 300g, Herba Artemisiae Scopariae 300g, Radix Salviae Miltiorrhizae 400g, Rhizoma Alismatis 400g, Radix Notoginseng 300g, Stigma Maydis 400g, to soak in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates are combined, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state by component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; As component 2; Then component 1 is added appropriate pharmaceutical grade methylcellulose and component 2 mixes, add appropriate propolis after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal of bottling after ultraviolet ray sterilization bactericidal.

Pharmacological toxicity is tested

One, test material:

(1) laboratory animal: mouse NIH, body weight 25-28g, male and female half and half; Rats Wistar body weight 130-160g, male and female half and half, the feedstuff of rat, mice is provided by Shandong medical college animal experimental center.

(2) test medicine:

1, medicine of the present invention: the oral liquid that embodiment 2 is made, applies with distilled water diluting during three batch equal amount of mixture experiments.

2, positive control medicine: JINGUI SHENQI WAN, commercially available.

Two, test method and result:

(1) get the healthy mice 80 of body weight 25-28g, female, hero half and half, is divided into four groups respectively by sex and body weight, often organizes 20.1, take medicine of the present invention for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, 4.2g crude drug/kg/d, and take positive control drug JINGUI SHENQI WAN for the 4th group, dosage is 6g crude drug/kg/d, is used in conjunction 15 days.

Result of the test: 1,2,3 groups of mices obviously strengthen than 4 groups of mice sexual excitation degree, the number of copulations of 1,2,3 group of mice average every day increases by 3 times than the number of copulations of 4 groups of mices.

Result of the test shows that medicine of the present invention has obvious excitation to central nervous system, thus medicine of the present invention for adjustment human body function equilibrium, QI invigorating, enrich blood, slow down aging strengthens metabolism, neurolysis, sexual hypofunction has treatment foundation.

Animal acute toxicity test of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..

(2) test medicine: the oral liquid that the present invention is made, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the oral liquid that the embodiment of the present invention is made.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 12 days is observed in remaining 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with the heavy dose of coloclysis of the present invention six months, increases the growth of rat, body weight, all has no side effect to brain, Liver and kidney function.Do not find that infringement changes to each histoorgan of rat, blood circulation, medication group compares no significant difference with matched group.Illustrate that medicine of the present invention has warming and recuperating the kidney-YANG, QI invigorating, enriches blood, slow down aging strengthens the drug effects such as metabolism, avirulence.

Pharmacodynamic experiment:

1 materials and methods

1.1 material

1.1.1 medicine oral liquid of the present invention (prepared by preparation method 2, be prepared into the reagent containing crude drug 0.2g/ml), is provided by preparation section of the court; Metformin hydrochloride (Shanghai Fahrenheit pharmacy).

1.1.2 animal Kunming mouse 96, male and female half and half, body weight (22.5 ± 2.5) g, provides by Shandong University's animal experimental center.

1.1.3 reagent and instrument streptozotocin (STZ) (SERVER company), purchased from magnificent company.Electronic balance AB204-WO type (prunus mume (sieb.) sieb.et zucc. Teller-Tuo company limited of Switzerland); Hitachi 7150 type automatic clinical chemistry analyzer (Japan).

1.2 method

1.2.1 modeling and grouping diabetes: animal is bought back, after adaptability feeds 1 week, be divided into normal non-diabetic group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling adopts the injection of STZ55mg/kg disposable celiac, within after administration 24 hours, survey blood glucose, glucose in urine, for three days on end, glucose in urine is qualitative +++ more than, blood glucose value is more than 16.5mmol/L, and continue constant person, be defined as diabetes and formed.

Modeling success mice is divided into 5 groups, the high, medium and low concentration group of model control group, metformin group, oral liquid of the present invention at random.

Hyperlipemia: animal is bought back, after adaptability feeds 1 week, be divided into normal non-hyperlipemia group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling gives more than 1 week containing 1% cholesterol, the high lipoprotein emulsion of 20% Adeps Sus domestica, 2% sodium cholate, 1% propylthio pyrimidine, every day 1 time, continuous 7 days.Modeling success mice is divided into 5 groups, the high, medium and low concentration group of model control group, metformin group, decocting liquid of the present invention at random.

1.2.2 administration and assay method Normal group and model control group (the isopyknic normal saline of ig); Metformin hydrochloride group (ig, 0.20g/kg); Oral liquid group of the present invention (ig every day decocting liquid 2.0g/kg of the present invention respectively, 3.0g/kg, 4.0g/kg).Each group of difference gastric infusion, 1 time/d, continuous 30 days.12h fasting before last administration, 2h after administration, plucks eye and gets blood, measures blood glucose and blood fat with automatic clinical chemistry analyzer.

1.2.3 all data of statistical procedures represent with "-χ ± S ", data acquisition SPSS11.5 statistical software analyzing and processing, if compare homogeneity of variance one way analysis of variance between many groups, if heterogeneity of variance rank test, compare and use paired t-test before and after in group.

2 results

As shown in Table 1, the high, medium and low concentration group of decocting liquid of the present invention all significantly can reduce the blood glucose of hyperglycemia mouse model, compares with model control group, and difference has statistical significance (P < 0.05) in 2.1 blood sugar lowering experiments.

The impact (-χ ± S) of table 1 Oral Liquid On Mice blood glucose of the present invention

Note: compare with Normal group, Δ Δ P < 0.01; Compare with model control group, * P < 0.05, * * P < 0.01; NS, normal saline.

2.3 blood fat reducing experiment as shown in Table 2, the high, medium and low concentration of oral liquid of the present invention all obviously can reduce TC, TG content of hyperlipemia mice model, compare with model control group, difference has statistical significance (P < 0.05, P < 0.01).

Table 2 the present invention is on the impact (χ ± S) of lipid of mice

3 discuss

In recent years, along with improving constantly of people's living standard, the disease incidence such as diabetes, coronary heart disease increases day by day.In the blood of people, lipid contained in blood plasma is called blood fat, comprise cholesterol, cholesterol ester, triglyceride, phospholipid and not esterified fat acid etc. several.When cholesterol, triglyceride etc. all exceed normal value, be then referred to as hyperlipemia.Hyperlipemia is atherosclerotic Main Etiological Factors.Often cause serious consequence, as coronary heart disease, diabetes, cerebrovas-cularaccident, intractable hypertension and the nephrotic syndrome, pancreatitis, calculosis, fatty liver etc. because invading vitals.Arteriosclerotic generation and development, have close relationship with Hyperlipemia.Chinese herbal medicine effect is stablized, few side effects, and research has the Chinese herbal medicine of hypoglycemic lipid-lowering effect, can provide more method for clinical treatment diabetes, hyperlipemia.Radix Oenotherae erythrosepalae oil is the most important nutrient drug found this century.Seed oil-containing 20 ~ 30%, in oil, 70% is linoleic acid, and 8 ~ 9% is the gamma-Linolenic acid of needed by human.Radix Oenotherae erythrosepalae oil can treat various diseases, regulate lipid material in blood, the diseases such as the coronary ligation caused hypercholesterolemia, hyperlipidemia, atherosis and cerebral thrombosis have significant curative effect, also can treat multiple sclerosis, diabetes, obesity, rheumatic arthritis and schizophrenia etc., in laboratory, also find the effect that it has anticancer to grow.Utilize the anti-cardiovascular blockage of Radix Oenotherae erythrosepalae oil energy clinically, reduce this characteristic of cholesterol, make specific medicament, for prevention and cure of cardiovascular disease.

Specific embodiment: Huan Zhenan, Lee 55 years old, is always stranded for nearly about 2 years, and total sleepy is felt, how to sleep also inadequate.In May, 2010, Physical examination found that blood pressure is very high.Check result: blood pressure: 150/100 mercury column.Body weight: 74 kilograms.Height: 168CM. blood routine examination: lymphocyte 44.5 term of reference 20-40%.Routine urianlysis: specific gravity of urine 1.030 term of reference 1.01-1.025.Protein+biochemical investigation: blood glucose 5.04 (on an empty stomach), T-CHOL 5.31 (on an empty stomach), triglyceride 4.72, HDL-C 1.54, low-density lipoprotein cholesterol 3.24.Colorful ultrasonic medical diagnosis report: hyperlipidemia, fatty liver.Once treated situation and effect: depressor of taking medicine; Levamlodipine beaylate tablets, fenofibrate micronized capsules, lose effect.Resistance is compared to Chinese medicine mouthfeel abnormal smells from the patient.Suggestion uses Radix Oenotherae erythrosepalae oral liquid of the present invention, and mouthfeel is good, Fang Yong: seed of Radix Oenotherae erythrosepalae 45g, Radix Trichosanthis 12g, Fructus Crataegi 13g, Cortex Lycii 12g, Rhizoma Curcumae Longae 13g, Flos Carthami 12g, Rhizoma Chuanxiong 13g, Radix Rehmanniae 13g, Fructus Ligustri Lucidi 12g, Rhizoma Polygoni Cuspidati 12g, Caulis Polygoni Multiflori 13g, Herb Gynostemmae Pentaphylli 12g, Semen Cassiae 13g, Poria 12g, Radix Paeoniae Rubra 13g, Herba Artemisiae Scopariae 12g, Radix Salviae Miltiorrhizae 12g, Rhizoma Alismatis 12g, Radix Notoginseng 12g, Stigma Maydis 12g, make oral liquid by embodiment method 2 to use, every day 2 times, each 1 bottle.It within 15 days, is 1 course for the treatment of.After using 2 courses for the treatment of, triglyceride levels is still too high, and suggestion diet strictly controls, eat fat, greasy food less, eat veterinary antibiotics more, increase quantity of motion, control on the basis of body weight etc., reduce taking of Western medicine, take oral liquid of the present invention and just can control.If blood pressure, blood fat are still felt not have strength, feel sleepy, the symptoms such as waist soreness, continued to take Chinese medicine oral liquid and nurse one's health a period of time after controlling ideal, recover normal.

Claims

1. the Radix Oenotherae erythrosepalae health care oral liquid of a blood fat reducing, it is characterized in that, the parts by weight of described health care oral liquid crude drug comprise: Radix Oenotherae erythrosepalae 10 ~ 50 parts, Radix Trichosanthis 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Cortex Lycii 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, 10 ~ 20 parts, Flos Carthami, Rhizoma Chuanxiong 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Semen Cassiae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Alismatis 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts.

2. the Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing according to claim 1, it is characterized in that, the parts by weight of described health care oral liquid crude drug comprise: Radix Oenotherae erythrosepalae 10 ~ 30 parts, Radix Trichosanthis 10 ~ 15 parts, Fructus Crataegi 10 ~ 15 parts, Cortex Lycii 10 ~ 15 parts, 10 ~ 15 parts, Rhizoma Curcumae Longae, 10 ~ 15 parts, Flos Carthami, Rhizoma Chuanxiong 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Semen Cassiae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Alismatis 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts.

3. the Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing according to claim 1, it is characterized in that, the parts by weight of described health care oral liquid crude drug comprise: Radix Oenotherae erythrosepalae 10 ~ 40 parts, Radix Trichosanthis 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Cortex Lycii 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, 10 ~ 20 parts, Flos Carthami, Rhizoma Chuanxiong 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Semen Cassiae 10 ~ 15 parts, 10 ~ 15 parts, Poria, Radix Paeoniae Rubra 10 ~ 15 parts, Herba Artemisiae Scopariae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Alismatis 10 ~ 15 parts, Radix Notoginseng 10 ~ 15 parts, Stigma Maydis 10 ~ 15 parts.

4. a Radix Oenotherae erythrosepalae health care oral liquid for blood fat reducing according to any one of claims 1 to 3, is characterized in that, the preparation process of described Chinese medicine health-care oral liquid comprises:

A. the extraction of Radix Oenotherae erythrosepalae, as component 1;

C. by add after pharmaceutical grade methylcellulose in component 1 and component also 2-in-1, add dextrin and be in harmonious proportion, after disinfection, be prepared into health oral liquor.

5. the preparation method of the Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing according to claim 4, is characterized in that, in described step a, chooses Maturity high, without insect pest, without rotting, and the evening primrose seed of no-sundries; Adopt cryogenic high pressure cold pressing process, namely adopt pure physical squeezing technique, overall process is all carried out under low temperature 35 DEG C of states, collects, the Radix Oenotherae erythrosepalae oil after cold pressing as component 1.

6. the preparation method of the Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing according to claim 4, it is characterized in that, in described step b, the medicine of all the other crude drug is put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.05 filtrate.

7. the preparation method of the Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing according to claim 4, it is characterized in that, in described step b, comprise further and the filtrate of extraction is concentrated, inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, becomes component 2.

8. the preparation method of the Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing according to claim 4, is characterized in that, in described step c, the Radix Oenotherae erythrosepalae of component 1 is extracted oil and adds appropriate pharmaceutical grade methylcellulose, blending ingredients 2, stirs and adds dextrin mediation, bottle after ultraviolet ray sterilization bactericidal.

9. blood fat reducing according to any one of claims 1 to 3 Radix Oenotherae erythrosepalae health care oral liquid a preparation method, it is characterized in that, its preparation process can also be:

B. all the other crude drug described soaked, extract 3 times as component 2;

C. component 1 is added pharmaceutical grade methylcellulose and component 2 mixes, add appropriate propolis after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

10. the preparation method of the Radix Oenotherae erythrosepalae health care oral liquid of blood fat reducing according to claim 9, is characterized in that, in described step b, to be soaked by all the other crude drug in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2.