CN104904964A - Folium apocyni veneti health tea capable of decreasing sugar and lipid and preparation method thereof - Google Patents

Abstract

The invention provides a folium apocyni veneti health tea capable of decreasing sugar and lipid. The folium apocyni veneti health tea is prepared from the following raw materials in parts by weight: 10 to 50 parts of folium apocyni veneti, 10 to 20 parts of rhizoma alismatis, 10 to 20 parts of leonurus, 10 to 20 parts of polygonum cuspidatum, 10 to 20 parts of semen cassiae, 10 to 20 parts of abrus cantoniensis hance, 10 to 20 parts of hawthorn, 10 to 20 parts of turmeric, 10 to 20 parts of fructus gardenia, 10 to 20 parts of loranthus parasiticus, 10 to 20 parts of flos sophorae, 10 to 20 parts of glossy privet fruit, 10 to 20 parts of polygala tenuifolia, 10 to 20 parts of gynostemma pentaphylla, 10 to 20 parts of selfheal, 10 to 20 parts of lotus leaf, 10 to 20 parts of radix paeoniae alba, and 10 to 20 parts of astragalus membranaceus. According to the folium apocyni veneti health tea, the traditional Chinese medicines are multi-target by being compared with Western medicine which is fast to act and high in effect, and the traditional Chinese medicines can decrease the blood pressure and treat other pathological links of diabetes and high blood pressure; therefore, the folium apocyni veneti health tea has the effects of improving microcirculation, decreasing the lipid and resisting oxidation, protecting endothelium, and modifying vaso-active substances.

Description

Folium Apocyni Veneti health protection tea of a kind of hypoglycemic and preparation method thereof

Technical field

The present invention relates to the health products containing deriving from plant composition, particularly a kind of Folium Apocyni Veneti health protection tea and preparation method thereof of hypoglycemic.

Background technology

Along with the raising of people's living standard, the illness rate of China coronary heart disease crowd is also improving constantly, and sicken age is tending towards rejuvenation, and coronary heart disease has become the killer of serious threat people life.The main cause of coronary heart disease is coronary atherosclerosis, and atherosclerotic is also the one of the main reasons of other position arterial disease.Causing arteriosclerotic hazards has a lot, such as hyperlipidemia (especially hypercholesterolemia), diabetes, and hypertension is fat or overweight, smoking etc., and wherein hypercholesterolemia is the most important hazards of atherosclerotic.One of most important progress of modern medicine is exactly specify that to lower blood cholesterol (TC) especially LDL.C, can significantly reduce coronary heart disease case fatality rate.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, add that long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, the agricultural chemicals remained in the absorption of a large amount of three height (high heat, high protein, higher fatty acid), more than three (anticorrisive agent is many, flavoring agent is many, hormone many) food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, obesity and diabetes have just become the rich man's disease of city gang.

When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Diabetes are a kind of syndrome due to insulin secretion, insulin action or both carbohydrate, protein and fat metabolic disturbances simultaneously caused by existing defects.Essential characteristic is that blood sugar increases, long-term damage is dysfunction and the exhaustion of various organ, comprise the vascular conditions of constantly progress, namely PVR, blind, ephrosis, renal failure, DPN companion foot ulcers, amputation and autonomic nervous function change, and also have the danger of ever-increasing cardiovascular, the cerebrovascular and peripheral angiopathy.

Folium Apocyni Veneti, another name: bluish dogbane, wartwort fiber crops, wild tealeaves, sage, wild flax; Latin literary fame: dogbane leaf. Angiospermae, Dicotyledoneae, the leaf of bluish dogbane, many shrinkages are curling, some fragmentations, in ellipticity lanceolar or oval shape lanceolar after intact leaf flattens, long 2 ~ 5cm, wide 0.5 ~ 2cm, light green or celadon, tip is blunt, has little awns point, the blunt circle of base portion or wedge shape, edge tool serration, Chang Fanjuan, two sides is without hair, and vein is in lower surface projection; Petiole is thin, is about 4mm.Matter is crisp.Its gas is micro-, lightly seasoned sweet, bitter, cold.Return Liver Channel.Function with cure mainly: flat liver is calmed the nerves, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; High blood pressure, neurasthenia, ephritis edema.

Folium Apocyni Veneti is cold in nature. and taste is sweet, bitter, and flat liver is calmed the nerves, clearing away heat and promoting diuresis.Main component rutin sophorin, catechu rope, isoquercitrin rope, glutamic acid, alanine, valine, potassium chloride etc., wherein antihypertensive compositions is Quercetin, general flavone, have hypotensive, strengthen capillary resistance, reduce capillary fragility, fall that blood refers to, coronary artery dilator increases coronary blood flow effect.And pass through VSMC voltage dependent Ca 2+ channels and the effect of receptor-operated Ca2+ passage double inhibition, reduce Intracellular signaling level, this may be one of vasodilator Hypotensive Mechanism.

Pharmacological action: Folium Apocyni Veneti decoction has hypotensive effect; Root of Apocynum venetum L decoction has cardiotonic; Folium Apocyni Veneti medicinal extract has calmness, anticonvulsant action, and have stronger diuresis, reduce blood fat, immunity moderation, anti-ageing and suppress the effect such as influenza virus.Bad reaction: Folium Apocyni Veneti preparation is for oral administration can occur nausea,vomiting,diarrhea, epigastric discomfort, also can occur bradycardia and proiosystole.Dizziness can be there is when inhaling bluish dogbane cigarette, choke cough, feel sick, insomnia etc.

Modern selects some health foods or functional food to be to improve the health.The function of health products mainly improves blood circulation of human body, enriching yin and nourishing kidney, improves body immunity.The various health products sold on the market now, dragons and fishes jumbled together for medicine, and the amusement of great majority just false propaganda, what have does not only have health-care components, also causes the huge injury of the person.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of Folium Apocyni Veneti not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.Chinese medicine can play assistant hypoglycemic step-down, lipopenicillinase, reduces Western medicine side effect, and reduce Western medicine intake, the effect of consolidate curative effect, as the health-care effect that health products supplemental treatment has had.In a word, though Chinese medicine hypoglycemic hypotensive effect does not have, Western medicine speed is fast, effect is strong, and more its effect harrows a little; while step-down, diabetes, other pathology links hypertensive can also be taken into account, have improve microcirculation, lipopenicillinase is anti-oxidant; protection endothelium, regulates the effects such as vaso-active substance.Therefore, Chinese medicine obviously can improve diabetes, hypertensive clinical symptoms, improves the quality of life of patient, along with further developing of scientific and technical means, believes that Chinese medicine hypoglycemic hypotensive effect prospect is boundless.

Summary of the invention

Technical problem to be solved by this invention is, Chinese medicine can play assistant hypoglycemic step-down, lipopenicillinase, reduces Western medicine side effect, and reduce Western medicine intake, the effect of consolidate curative effect, as the health-care effect that health products supplemental treatment has had.In a word, though Chinese medicine hypoglycemic hypotensive effect does not have, Western medicine speed is fast, effect is strong, and more its effect harrows a little; while step-down, diabetes, other pathology links hypertensive can also be taken into account, have improve microcirculation, lipopenicillinase is anti-oxidant; protection endothelium, regulates the effects such as vaso-active substance.Therefore, Chinese medicine obviously can improve diabetes, hypertensive clinical symptoms, improves the quality of life of patient.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.Folium Apocyni Veneti is cold in nature. and taste is sweet, bitter, and flat liver is calmed the nerves, clearing away heat and promoting diuresis.Main component rutin sophorin, catechu rope, isoquercitrin rope, glutamic acid, alanine, valine, potassium chloride etc., wherein antihypertensive compositions is Quercetin, general flavone, have hypotensive, strengthen capillary resistance, reduce capillary fragility, fall that blood refers to, coronary artery dilator increases coronary blood flow effect.The micro-bitter glycol of the present invention; Add some promoting blood circulation and removing blood stasis, mouthfeel is light, makes people be easy to the Chinese medicine accepted, can reach effect of hypoglycemic preferably.

For solving above-mentioned technical barrier, the invention provides a kind of Folium Apocyni Veneti health protection tea of hypoglycemic, described in it, Folium Apocyni Veneti health protection tea comprises the raw material of following parts by weight: Folium Apocyni Veneti 10 ~ 50 parts, rhizoma alismatis 10 ~ 20 parts, motherwort 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, cassia seed 10 ~ 20 parts, Canton love-pea vine 10 ~ 20 parts, hawthorn 10 ~ 20 parts, 10 ~ 20 parts, turmeric, cape jasmine 10 ~ 20 parts, parasitic loranthus 10 ~ 20 parts, 10 ~ 20 parts, sophora flower, the fruit of glossy privet 10 ~ 20 parts, polygala root 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, selfheal 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, the root of herbaceous peony 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts.

The Folium Apocyni Veneti health protection tea of described hypoglycemic, in Folium Apocyni Veneti health protection tea described in it, the parts by weight of various raw material can be: Folium Apocyni Veneti 10 ~ 40 parts, rhizoma alismatis 10 ~ 15 parts, motherwort 10 ~ 15 parts, giant knotweed 10 ~ 15 parts, cassia seed 10 ~ 15 parts, Canton love-pea vine 10 ~ 15 parts, hawthorn 10 ~ 15 parts, 10 ~ 15 parts, turmeric, cape jasmine 10 ~ 15 parts, parasitic loranthus 10 ~ 20 parts, 10 ~ 20 parts, sophora flower, the fruit of glossy privet 10 ~ 20 parts, polygala root 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, selfheal 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, the root of herbaceous peony 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts.

The Folium Apocyni Veneti health protection tea of described hypoglycemic, in Folium Apocyni Veneti health protection tea described in it, the parts by weight of various raw material can also be: Folium Apocyni Veneti 10 ~ 30 parts, rhizoma alismatis 10 ~ 20 parts, motherwort 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, cassia seed 10 ~ 20 parts, Canton love-pea vine 10 ~ 20 parts, hawthorn 10 ~ 20 parts, 10 ~ 20 parts, turmeric, cape jasmine 10 ~ 20 parts, parasitic loranthus 10 ~ 15 parts, 10 ~ 15 parts, sophora flower, the fruit of glossy privet 10 ~ 15 parts, polygala root 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, selfheal 10 ~ 15 parts, 10 ~ 15 parts, lotus leaf, the root of herbaceous peony 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of Folium Apocyni Veneti health protection tea of hypoglycemic, and the preparation process of described Folium Apocyni Veneti health protection tea comprises following aspect:

A. Folium Apocyni Veneti harvesting, knead, Titian;

B. heat extraction 2 times by all the other raw material soaking ethanol described, dregs of a decoction extracting in water 2 times again, merges;

C. the concentrate concentrated extract of all the other raw materials is become medicinal extract, add honey or dextrin makes granule, pulvis or paste;

D. granule, pulvis or paste that the Folium Apocyni Veneti prepared and above-mentioned steps obtain are mixed, pack after ultraviolet sterilization.

In described step a, at annual harvesting in summer Folium Apocyni Veneti, plucked to spread out and shone or dry, sieve discarding stalk, raises clean impurity; First knead 10-15 minute with the little fire of iron pan, be then put into fragrance extracting machine Titian 10-20 minute.

In described step b, all the other raw medicinal materials can be mixed, steep in ethanol, soak more than 2 hours, add the alcohol extract 2 times of 8 times amount of Folium Apocyni Veneti gross weight, 6 times amount respectively, extraction time is 2 hours, 1 hour; Merge No. 2 extracts, extract is centrifugal by tubular type, obtains centrifugate, and centrifugate is crossed D 101 macroreticular resin and adsorbed, and first washes removal of impurities with water, then carries out wash-out with the ethanol of 70%, collects eluent, merges standing.

In described step c, above-mentioned steps can be obtained extract, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, medicinal extract is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount; Paste after concentrated adds dextrin or granule made by honey.

For solving the problems of the technologies described above, the present invention reoffers the preparation method of a kind of Folium Apocyni Veneti health protection tea of hypoglycemic, and the step that city pulvis prepared by other raw materials can also be:

A, get other raw materials and put into ethanol and soak, heat is extracted 3 times;

B, extract is positioned in inspissator concentrated, is then dried to pulvis.

In described step a, all the other bulk drugs can be soaked in ethanol 12 hours, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds ethanol, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds ethanol again, and half an hour is boiled in third time heating, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, are condensed into pasty state.

In described step b, the raw material pasty state liquid that can extract, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, and by gained concentrate adjustment proportion to 1.46, decompression, the pasty state liquid after concentrated is put into drying machine and is dried to pulvis.

The technique effect that the present invention is useful is, Chinese medicine can play assistant hypoglycemic step-down, lipopenicillinase, reduces Western medicine side effect, and reduce Western medicine intake, the effect of consolidate curative effect, as the health-care effect that health products supplemental treatment has had.In a word, though Chinese medicine hypoglycemic hypotensive effect does not have, Western medicine speed is fast, effect is strong, and more its effect harrows a little; while step-down, diabetes, other pathology links hypertensive can also be taken into account, have improve microcirculation, lipopenicillinase is anti-oxidant; protection endothelium, regulates the effects such as vaso-active substance.Therefore, Chinese medicine obviously can improve diabetes, hypertensive clinical symptoms, improves the quality of life of patient.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.The micro-bitter glycol of the present invention; Add some promoting blood circulation and removing blood stasis, mouthfeel is light, makes people be easy to the Chinese medicine accepted, can reach effect of hypoglycemic preferably.

Detailed description of the invention

High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, a large amount of three height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) agricultural chemicals residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.

Chinese medicine can play secondary buck, lipopenicillinase, reduces Western medicine side effect, reduces Western medicine intake, the effect of consolidate curative effect.In a word, though Chinese medicine for lowering high blood pressure effect does not have, Western medicine speed is fast, effect is strong, and more its effect harrows a little; while step-down, other pathology links hypertensive can also be taken into account, have improve microcirculation, lipopenicillinase is anti-oxidant; protection endothelium, regulates the effects such as vaso-active substance.Therefore, Chinese medicine can obviously improve hypertensive clinical symptoms, improves the quality of life of patient, along with further developing of scientific and technical means, believes that Chinese medicine for lowering high blood pressure effect prospect is boundless.

In side, giant knotweed, Folium Apocyni Veneti have calming the liver to stop the wind effect, with thinking monarch.Cassia seed nature and flavor Cheng Ping, function is calming the liver, heat extraction improving eyesight, share with polygala root, selfheal, strengthens calming the liver to stop the wind power.Cape jasmine is ensuringd proper downward flow of the blood, and is ministerial drug altogether.Fruit of glossy privet clearing heat-fire, make the heat of Liver Channel unlikely on disturb; Canton love-pea vine is clearing heat and detoxicating, activating blood and promoting diuresis, and parasitic loranthus tonifies the liver and kidney; Polygala root tranquilizing the mind, is adjutant.Close and with it, become calming the liver to stop the wind altogether, heat clearing and blood circulation promoting, the side of the hypoglycemic that tonifies the liver and kidney

Folium Apocyni Veneti, another name: bluish dogbane, wartwort fiber crops, wild tealeaves, sage, wild flax; Latin literary fame: dogbane leaf. Angiospermae, Dicotyledoneae, the leaf of bluish dogbane, many shrinkages are curling, some fragmentations, in ellipticity lanceolar or oval shape lanceolar after intact leaf flattens, long 2 ~ 5cm, wide 0.5 ~ 2cm, light green or celadon, tip is blunt, has little awns point, the blunt circle of base portion or wedge shape, edge tool serration, Chang Fanjuan, two sides is without hair, and vein is in lower surface projection; Petiole is thin, is about 4mm.Matter is crisp.Its gas is micro-, lightly seasoned sweet, bitter, cold.Return Liver Channel.Function with cure mainly: flat liver is calmed the nerves, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; High blood pressure, neurasthenia, ephritis edema.

Pharmacological action: Folium Apocyni Veneti decoction has hypotensive effect; Root of Apocynum venetum L decoction has cardiotonic; Folium Apocyni Veneti medicinal extract has calmness, anticonvulsant action, and have stronger diuresis, reduce blood fat, immunity moderation, anti-ageing and suppress the effect such as influenza virus.Bad reaction: Folium Apocyni Veneti preparation is for oral administration can occur nausea,vomiting,diarrhea, epigastric discomfort, also can occur bradycardia and proiosystole.Dizziness can be there is when inhaling bluish dogbane cigarette, choke cough, feel sick, insomnia etc.

Clinical practice, is used for Hypertension, every daily Folium Apocyni Veneti 1 ~ 2 money, and boiling water bubble drinks as a tea; Or timing decoction sooner or later.Control 596 examples altogether, wherein alone Folium Apocyni Veneti 169 example; Unstable and use bluish dogbane instead by other depressor effects, or depressor and the same use of bluish dogbane, blood pressure to drop to a certain degree counts with the bluish dogbane person of consolidation again 427 routine.Result transference cure or show alleviator 254 example, alleviates 212 examples; Wherein blood pressure drops to below 140/90 millimetres of mercury person 143 people, and systolic pressure or diastolic pressure decline 20 millimetres of mercury above person 268 people.Efficiently reach 88.59%.Medicine time, longer then curative effect was higher, and what exceed half a year reaches 93.3%; But the curative effect of bluish dogbane and course of disease length are without obvious relation.To headache, dizzy, brain is swollen, insomnia and dreamful sleep and edema have this medicine of good mitigation comparatively suitable to I, II phase patient; Or as the adjuvant of Hypertension, have good therapeutic effect to improving symptom.

But also there is side effect: more is borborygmus, diarrhoea; Occasionally there is stomachache, have no appetite, dry, bitter taste; Indivedual appearance asthma or hepatodynia.But also there is side effect: more is borborygmus, diarrhoea; Occasionally there is stomachache, have no appetite, dry, bitter taste; Indivedual appearance asthma or hepatodynia.The Chinese medicine that the present invention adds, can well alleviate or eliminate the side effect of Folium Apocyni Veneti, applies and saferly to feel at ease, can Long-Time Service.

Parasitic loranthus bitter, sweet, property is put down.Return liver, kidney channel.Property get a breathing space and, can rise and can fall.1. filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic.Lose for kidney deficiency and liver, the deficiency of blood that articular instability, the muscles and bones impotence of supporting are soft, soreness of waist and knee joint, as duhuo jisheng decoction.2. nourishing blood and preventing abortion.This product energy nourishing blood and preventing abortion gas, the solid feotus vitality of kidney tonifying, for deficiency of blood fetal irritability.These product are sweet flat, function tonifies the liver and kidney, strengthening the muscles and bones, taste sweet again can wines used as antirheumatic, treat numbness pain, by lumbago due to the kidney deficiency, fetal irritability and rheumatism with the passing of time body ressitance weakened while pathogenic factors prevailing commonly used.Parasitic loranthus is the most suitable to arthralgia due to wind-dampness, kidney deficiency and liver, soreness of waist and knee joint, and the normal and compatibility such as levisticum, the root of bidentate achyranthes is applied., women through multi-band under kidney deficiency and liver, lumbocrural pain, muscles and bones unable person empty to old man's body also often apply with the compatibility such as cassia seed, teasel root.Suffer from a deficiency of the kidney for liver lose, blood, fetal irritability under threatened abortion caused by the debility of chong and ren channels, the compatibilities such as normal and teasel root, the seed of Chinese dodder, donkey-hide gelatin.In addition, these product have hypotensive effect again, are usually used in hypertension clinically in recent years.

The root of herbaceous peony is cool in nature, and bitter acid, is slightly cold, has soft liver of enriching blood, flat liver pain relieving.Astringe yin receives the effects such as sweat, is applicable to fever due to yin deficiency, irregular menstruation, chest abdomen pain over the hypochondriac region, four limbs contraction suddenly, rushes down dysentery stomachache, spontaneous sweating, uterine bleeding, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, anti-inflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, hemangiectasis, antagonism acute myocardial ischemia, Antiaggregating activity on platelet, calmness, analgesia, spasmolysis, antiulcer, adjustment blood sugar.Root of herbaceous peony decoction can suppress shigella dysenteriae, streptococcus pneumonia, Escherichia coli, typhoid bacillus, hemolytic streptococcus, Pseudomonas aeruginosa etc.The deficiency of blood deficiency of Yin, chest abdomen pain over the hypochondriac region, pain in the hepatic region, cholecystitis, gallstone pain, to rush down the condition subject such as dysentery stomachache, women's menalgia, spontaneous perspiration easy sweat night sweat, systremma, spasm of limbs pain, uneasy leg syndrome suitable edible.

The dry mature seed that cassia seed (formal name used at school: Catsia tora Linn) is pulse family annual herb plant Cassia tora or little Cassia tora.Cassia seed is also Cassia occidentalis.Cassia seed is annual suffruticose draft; The brightly yellowish look of Cassia tora, pod is elongated, four prism type; Little Cassia tora plant is less, and pod is shorter, is one of important composition.Have the merit of improving eyesight fat-reducing with it and name it.Cassia seed bitter, sweet, one-tenth, cold nature, enters liver, kidney, large intestine channel; Relax bowel, lipopenicillinase improving eyesight, treatment constipation and high fat of blood, hypertension.Clear liver and improve vision, sharp water defaecation, has laxative action, reducing blood pressure and blood fat.

Sophora flower bitter, property is put down, nontoxic, has effect of heat-clearing, cool blood, hemostasis, step-down.Significant curative effect is had to haematemesis, hematuria, hemorrhoid hemorrhage, wind-heat hot eyes, high blood pressure, hyperlipidemia, the tuberculosis of cervical lymph nodes, vascular sclerosis, stool band blood, diabetes, the retinitis, psoriasis etc.; Can also expelling parasite, control pharyngitis.Sophora flower can strengthen the resistance of capillary, reduces vasopermeability, fragility blood vessel can be made to recover flexible function, thus reducing blood lipid and prevent vascular sclerosis.The traditional Chinese medical science thinks its bitter, cold nature, returns liver, large intestine channel; Enter blood to hold back and fall, body slightly falls apart; There is cooling blood and hemostasis, effect of clearing liver-fire; Cure mainly hematochezia, hemorrhoid blood, bloody flux, hematuria, blood drenches, uterine bleeding, spits blood, bleeding from five sense organs or subcutaneous tissue, and irascibility is had a headache, red eye, swell pain, larynx numbness, aphonia, ulcer sores.And from the angle of doctor trained in Western medicine, sophora flower containing the material such as rutin (i.e. rutin sophorin, Rytub), Quercetin (Quercetin), tannin, sophoradiol (sophoradiol), vitamin A (specifically can see below contain scale).Rutin can improve the function of capillary, and keep the normal resistance of capillary, prevent because capillary fragility is excessive, too high hemorrhage, hypertension, the diabetes caused of permeability, can preventing of clothes is hemorrhage.

The fruit of glossy privet, sweet-bitter flavor, cool in nature, return liver kidney channel, there is the merit that nourishing liver and kidney, beneficial the moon nourishes blood.Modern medicine study proves, the fruit of glossy privet includes ursolic acid, sweet mellow wine, glucose, fatty wet goods, has cardiac stimulant, diuresis and hepatoprotective effect, the leucocyte decline quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, Escherichia coli.The acid of the oleanolic acid fruit of glossy privet, Ligustrum lucidum Ait, ursolic acid, stearic acid, oleic acid, sweet mellow wine, betulin, phosphatide and carbohydrate is contained as Fructus Ligustri Lucidi polysaccharide, arabinose, glucose etc. in the fruit of glossy privet, also containing 15 seed amino acids, 11 kinds of trace elements and volatilization wet goods.Research thinks that the fruit of glossy privet has hypoglycemic and reducing blood lipid and has study of anti-atherogenic effect, and antibacterial, antivirus action in addition, fruit of glossy privet decoction all has inhibitory action to staphylococcus aureus, shigella flexneri, typhoid bacillus, Pseudomonas aeruginosa and Escherichia coli.

Motherwort taste is arduous, cool.Invigorate blood circulation, silt of dispelling, menstruation regulating, disappear water.Treatment menoxenia, threatened abortion is had difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood at hematuria, and carbuncle swells sore.Motherwort containing the material such as leonurine, fumaric acid, has the effects such as promoting blood circulation for regulating menstruation, hypotensive, inducing diuresis to reduce edema.

Hawthorn: modern study hawthorn is containing materials such as carbohydrate, protein, fat, vitamin C, carrotene, starch, malic acid, citric acid, calcium and iron, there is the effects such as reducing blood lipid, blood pressure, cardiac stimulant, arrhythmia, meanwhile, hawthorn is also the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting.The disease such as, hernia, blood stasis full to chest diaphragm spleen, amenorrhoea has good curative effect.Flavone compound Vitexin in hawthorn, be the medicine that a kind of antitumaous effect is stronger, haw thorn extract all has certain inhibitory action to cancer cell tumor growth, propagation and infiltration metastasis.Hawthorn energy prevention and cure of cardiovascular disease, has hemangiectasis, cardiac stimulant, increase CF, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, softening blood vessel and diuresis and sedation; Prevent and treat artery sclerosis, anti-aging, anticancer effect.Crataegolic acid also has cardiotonic, also benefits to senile heart disease.Its energy appetite-stimulating indigestion-relieving, offsets carnivorous stagnant effect especially better, all have employed hawthorn in a lot of digestant medicine; Hawthorn has contraction to uterus, pregnant woman just before giving birth time have the effect expedited the emergence of, and uterine involution in postpartum can be promoted; The immunity of body can be strengthened, have anti-aging, anticancer effect.Having in hawthorn relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.

Polygala root (formal name used at school: Polygala tenuifolia Willd.), another name: Lush Rao, Ji Tseng-Lan, sour jujube aster, little grass, thin grass, line catechu, little grass roots, refreshing sand grass.For Polygalaceae, rogation flower.Produce northeast, North China, northwest and Central China and Sichuan.Warm in nature, bitter, pungent, the function of have intelligence development of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for breakdown of the normal physiological coordination between the heart and the kidney, forgetful palpitation with fear, wandering, expectoration is not well, sore swollen toxin, mastosis.Clinical practice crude Radix Polygalae, RADIX POLYGALAE PREPARATA and honey polygala root three kinds.

Lotus leaf dietary function: lotus leaf bitter is pungent micro-puckery, cool in nature, the thoughts of returning home, liver, the spleen channel, delicate fragrance rises loose; Have summer heat relieving and dampness eliminating, invigorating the spleen rises sun, and effect of loose stasis of blood hemostasis, cures mainly hot summer weather polydipsia, have a headache dizzy, oedema, and the few abdominal distension of food, rush down dysentery, leukorrhea, prolapse of the anus, spit blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, has blood in stool, uterine bleeding, post partum longtime lochia, traumatic blood stasis.

Turmeric turmeric, (formal name used at school: Curcuma longa L.) promoting the circulation of qi can break the stasis of blood, inducing meastruation to relieve menalgia.Cure mainly chest and abdomen swelling and pain, shoulder arm numbness pain, irregular menstruation, amenorrhoea, traumatic injury.The stasis of blood is broken in the promoting the circulation of qi of turmeric energy, inducing meastruation to relieve menalgia.Cure mainly chest and abdomen swelling and pain, shoulder arm numbness pain, irregular menstruation, amenorrhoea, traumatic injury.Yellow food colour can be extracted again; Contained curcumin can perform an analysis chemical reagent.

Giant knotweed calls sour cylinder bar, sour bucket reed, large osteosynthesis, spot village root, Classification system: Polygonumcuspidatum, polygonaceae, giant knotweed platymiscium, perennial herb.Its juice can contaminate ground rice, has a distinctive flavour.Eat with its taste acid therefore also claim " sour soup bar ".Giant knotweed contains knotweed glucoside, organic acid, glycoside, polysaccharide etc.Having clearing heat and detoxicating, cooling and heatstroke-eliminating, stomach invigorating food effect clearly, is a kind of polygonaceae plant.Clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, loose stasis of blood analgesic therapy, relieving cough and reducing sputum.For joint pain, jaundice with damp-heat pathogen, through closing, postpartum blood stasis does not Xia ， wei lump in the abdomen, coughing with a lot of sputum, scald, traumatic injury, carbuncle sore tumefacting virus.

Canton love-pea vine latin name (Abrus cantoniensis), another name abrus cantoniensis Hance.Clearing heat and promoting diuresis, blood stasis removing analgesic.Main icteric hepatitis, stomachache, treating rheumatic ostealgia, falls and beats stasis of blood pain, breast pain Canton love-pea vine sweet and slightly bitter taste, cool in nature, returns liver, courage, stomach warp.On the impact of intestinal smooth muscle.For normal isolated rabbit ileum, Canton love-pea vine root decoction can significantly strengthen its shrinkage amplitude, and anesthetized rabbit gavage or intramuscular injection decoction also can make intestinal tube tension force in place improve, and wriggles and slightly strengthens.There is obvious inhibitory action at isolated guinea pig ileum test middle and high concentration decoction to the contraction caused by acetylcholine, but only have slight suppression caused by histamine, on person caused by barium chloride without impact.

Rhizoma alismatis taste is sweet; Light; Cold in nature.Clearing damp and promoting diuresis; Expel the heat-evil treating stranguria.Main difficult urination; Heat drenches puckery pain; Oedema turgor; Have loose bowels; Phlegmatic vertigo; Seminal emission.Rhizoma alismatis: be longer than clearing damp and promoting diuresis, expels the heat-evil, for difficult urination, and oedema turgor, the puckery pain of stranguria with turbid discharge, seminal emission, pin knee impotence is soft; Fry rhizoma alismatis, be partial to and spleen excreting dampness, for phlegm and retained fluid, rush down dysentery, vertigo.Rhizoma alismatis, Poria cocos, umbellate pore furgus; Three all can seep water dampness removing and inducing diuresis to reduce edema, and Chang Sanzhe is with using; Right rhizoma alismatis is cold in nature, can expel the heat-evil, clearly mutually fire; Poria cocos then can heart-spleen boosting, tranquilizing mind; And umbellate pore furgus, can only excreting dampness diuresis.The fat-soluble part of rhizoma alismatis has obvious norcholesterol effect and study of anti-atherogenic effect to experimental hypercholesterolemicrabbits rabbit, by the acetic acid esters of the alisol A be wherein separated, B and alisol A, B, C, except alisol B, there is the norcholesterol effect shown.Content with 0.1% adds in the feed of experimental atherosclerosis rats, and cholesterolemia can be made to decline more than 50%, wherein the strongest with the effect of alisol A-24-acetic acid esters.The ethanol extract of rhizoma alismatis, the ethyl acetate extract etc. of ethanol extract, have effect for reducing blood fat to experimental hypercholesterolemicrabbits rabbit and rat.Ethyl acetate extract is the strongest with its residual fraction effect be insoluble in acetic acid one water.Ethyl acetate extract oral 1g/kg every day, also has obvious norcholesterol effect to raising with the normal rat of normal diet.Prove by coordination list notation method, alisol A has the ability suppressing mouse small intestine esterified cholesterol, and the absorptivity of cholesterol in rat small intestine can be made to reduce by 34%, but does not affect linoleic absorption.

Cape jasmine: another name Yellow Fructus Gardeniae, mountain Cape jasmine, white toad are the fruits of madder wort cape jasmine.At present, the fruit of cape jasmine is traditional Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that the Ministry of Public Health promulgates, has effects such as protecting liver, cholagogic, step-down, calmness, hemostasis, detumescence.The diseases such as treatment icteric hepatitis, bruise, hypertension, diabetes are usually used at tcm clinical practice.Heat-clearing, purging intense heat, cool blood.Control pyreticosis restlessness of asrhenia type and insomnia, jaundice, gonorrhoea, quench one's thirst, hot eyes, pharyngalgia, spit blood, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, pathopyretic ulcer, sprains and swells and ache

Selfheal selfheal is cold in nature, sweet, pungent, the micro-hardship of taste, there is the effect of letting out clearly irascibility, mass dissipating and swelling eliminating, clearing heat and detoxicating, expelling phlegm and arresting coughing, cooling blood and hemostasis, under being applicable to scrofula, goitre, acute mastitis, vertigo, facial paralysis, arthralgia and myalgia, pulmonary tuberculosis, metrorrhagia, band, Fiedeler's disease type hepatitis and bacillary dysentery etc.Modern pharmacological research shows, selfheal has the effect reduced blood pressure, and energy hemangiectasis, contained by it, rutin has antiinflammatory action, and can reduce vasopermeability, reduces fragility, reduces liver fat.Selfheal also has the effect of resisting cancer cell." herbal classic ": main fever and chills, scrofula, mouse fistula, head sore, broken disease, loose goitre knot gas, pin swells arthritis with fixed pain caused by dampness." Amplification on Materia Medica addendum ": take a tonic or nourishing food to build up one's health blood vessels." the southern regions of the Yunnan Province book on Chinese herbal medicine ": liver wind of dispelling, network of passing through, controls facial paralysis.Row irritability, opens liver depression, only arthralgia and myalgia, ophthal malgia, and loose scrofula is stolen, whole body tuberculosis.

Gynostemma pentaphylla has adaptive capacity widely, has significant inhibitory action to multiple cancer cell; In addition, gynostemma pentaphylla also has reducing blood lipid, hypotensive, hypoglycemic, calm, hypnosis, anti-anxiety, antiulcer, antifatigue, prolongation cell survival and improves a poor appetite, build up resistance, unobstructed stool, antiasthmatic-antitussive, the hemorrhoid that disappear, fat-reducing, the treatment chronic diseases marked by deficiency of vital energy, suppression gall stone are formed, prevent and treat glucocorticoid side effect, anti-ageing multiple efficacies of waiting for a long time.Except the effect with ginseng, also there is the multiple effect that ginseng does not possess, and there is no reaction and any other toxic and side effect of ginseng excessive use.

The Radix Astragali is based on qi-restoratives, and energy invigorating qi for strengthening superficies, diuresis holder is malicious, apocenosis, expelling pus and promoting granulation.For insufficiency of vital energy and blood, sore caves in, purulence one-tenth is not burst or of a specified duration bursting does not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration, i.e. the abscess suppuration myogenic of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and can strengthen the immunologic function of body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five zang organs, controls arteries and veins string spontaneous perspiration, rush down yin fire, remove lung heat, lossless, sends out, has sweat then to stop." be the good medicine promoting resistance and defence disease.

Specific embodiment 1:

Pluck Folium Apocyni Veneti in annual early June to late October in annual summer, plucked to spread out and shone or dry, sieve discarding stalk, raises clean impurity, puts into iron pan and knead, then Titian.

Again by all the other raw material rhizoma alismatis, motherwort, giant knotweed, cassia seed, Canton love-pea vine, hawthorn, turmeric, cape jasmine, parasitic loranthus, sophora flower, the fruit of glossy privet, polygala root, gynostemma pentaphylla, selfheal, lotus leaf, the root of herbaceous peony, the Radix Astragali adds water or alcohol extract makes granule, pulvis or paste.

Mixed with the pulvis obtained, granule or paste by the Folium Apocyni Veneti prepared, ultraviolet radiation for sterilizing and disinfecting is bottled.

Specific embodiment 2:

To gather in annual summer Folium Apocyni Veneti in annual early June to late October, plucked to spread out and shone or dry, sieve discarding stalk, raises clean impurity, first kneads 10-15 minute with the little fire of iron pan, be then put into fragrance extracting machine Titian 10-20 minute.About 5000g.Get other raw material rhizoma alismatis 1500g again, motherwort 1500g, giant knotweed 1500g, cassia seed 1500g, Canton love-pea vine 1500g, hawthorn 1500g, turmeric 1500g, cape jasmine 1500g, parasitic loranthus 1500g, sophora flower 1500g, fruit of glossy privet 1500g, polygala root 1500g, gynostemma pentaphylla 1500g, selfheal 1500g, lotus leaf 1500g, root of herbaceous peony 1500g, Radix Astragali 1500g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, inserted in economic benefits and social benefits vacuum concentrator again, when being concentrated into 90 DEG C, relative density is the concentrate of 1.50, set to 0 ~ 5 DEG C of deepfreezes 24 hours, refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, be concentrated into every 1ml containing 0.2g crude drug amount, then add dextrin mediation to granulate, then mixed with the granule obtained by the Folium Apocyni Veneti prepared, ultraviolet radiation for sterilizing and disinfecting is bottled.

Specific embodiment 3:

To gather in annual summer Folium Apocyni Veneti in annual early June to late October, plucked to spread out and shone or dry, sieve discarding stalk, raises clean impurity, first kneads 10-15 minute with the little fire of iron pan, be then put into fragrance extracting machine Titian 10-20 minute.About 4000g.Get other raw material rhizoma alismatis 1200g, motherwort 1300g, giant knotweed 1200g, cassia seed 1200g again, Canton love-pea vine 1200g, hawthorn 1200g, turmeric 1200g, cape jasmine 1300g, parasitic loranthus 1200g, sophora flower 1200g, fruit of glossy privet 1100g, polygala root 1200g, gynostemma pentaphylla 1200g, selfheal 1200g, lotus leaf 1300g, root of herbaceous peony 1200g, Radix Astragali 1200g, get bulk drug clean dry, in 70 DEG C of baking ovens, dry 1-3h, take out and be placed in cooling in drying box, pulverized 80-100 mesh sieve with pulverizer.The Folium Apocyni Veneti be mixed with, one bubbles in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, be concentrated into every 1ml containing 0.5g crude drug amount, make paste, then the Folium Apocyni Veneti prepared is mixed with the paste obtained, ultraviolet radiation for sterilizing and disinfecting bottling ultraviolet disinfection, bottling.

Specific embodiment 4:

To gather in annual summer Folium Apocyni Veneti in annual early June to late October, pluck to spread out and shone or dry, sieve discarding stalk, raise clean impurity, first knead 10-15 minute with the little fire of iron pan, then fragrance extracting machine Titian 10-20 minute is put into, about 4200g, get other raw material rhizoma alismatis 1200g again, motherwort 1300g, giant knotweed 1200g, cassia seed 1200g, Canton love-pea vine 1200g, hawthorn 1200g, turmeric 1200g, cape jasmine 1300g, parasitic loranthus 1200g, sophora flower 1200g, fruit of glossy privet 1100g, polygala root 1200g, gynostemma pentaphylla 1200g, selfheal 1200g, lotus leaf 1300g, root of herbaceous peony 1200g, Radix Astragali 1200g, be mixed and put into acid and alkali-resistance infusion kettle, at room temperature, 3 ~ 7 days are flooded together with more than 70 degree ethanol, then heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill, filter, filtrate is got after separation, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge leaching liquor, being condensed into pasty state becomes component 2, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the paste of 1.60, paste after concentrated is put into drying machine and is dried to pulvis, again the Folium Apocyni Veneti prepared is mixed with the pulvis obtained, ultraviolet radiation for sterilizing and disinfecting bottling ultraviolet disinfection, bottling.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD 50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.

Pharmacological experiment:

Observe the present invention to the impact of animal used as test blood pressure and blood lipoid.Method: adopt the diabetic mouse model caused by alloxan, with streptozotocin mycin (STZ) and the method giving high caloric diet copies type ii diabetes rat model, treat respectively with the present invention, Glipizide, then claim its body weight, measure serum triglyceride, cholesterol, serum insulin content and carry out dextrose tolerance test.Result: the present invention obviously reduces the blood sugar of diabetic mice, alleviates the body weight of diabetes B rat, stops fat generation.Also can reduce Peripheral Blood insulin level simultaneously, improve the ubiquitous notable feature of this diabetes B of insulin resistance.Conclusion: the present invention has obvious hypoglycemic lipid-lowering effect.

1 materials and methods

1.1 animals used as test: Wister rat, male, body weight 200 ~ 250g; Every only about the 18 ~ 20g of Kunming mouse (male and female dual-purpose), above animal is the biological animal center of Shandong University and provides.

1.2 high-calorie feed: mixed with sucrose, refining lard by basal feed, its total amount of heat is 20.08KJ/g (protein 15%, carbohydrate 51%, fat 25%).

1.3 medicines and reagent: the present invention: Folium Apocyni Veneti 40g, rhizoma alismatis 12g, motherwort 13g, giant knotweed 11g, cassia seed 11g, Canton love-pea vine 11g, hawthorn 11g, turmeric 12g, cape jasmine 14g, parasitic loranthus 12g, sophora flower 11g, fruit of glossy privet 12g, polygala root 12g, gynostemma pentaphylla 13g, selfheal 12g, lotus leaf 12g, root of herbaceous peony 11g, Radix Astragali 12g, (purchased from Shandong College of Traditional Chinese Medicine's Baokang hospital clinic), make after water decoction-alcohol sedimentation 100% liquid for subsequent use.STZ is Sigma Products, lot number: S0130; Alloxan is Sigma Products, faces the used time is made into 1% solution with citric acid one sodium citrate buffer solution of 0.1mmol/L, pH4.2; Glipizide tablet is Hainan Jin Xiao pharmaceutical Co. Ltd product, lot number: 001213; Blood sugar kit, Cholesterol Kit, Triglyceride Reagent box and serum insulin radioimmunological kit are all purchased from Beijing Zhongsheng Biological Engineering High Technology Company.

1.4 laboratory apparatus: semi-automatic biochemical analyzer: EPPENDORF-F6124 type, Germany; Radioimmunoassay instrument: naval's Medical Devices head factory, China.

The preparation of 1.5 experimental models: the preparation of diabetic hyperlipemia rat model: rat tail vein fast injection STZ30mg/kg, feeds with basal feed, freely drinks water, and tail vein blood after 2 weeks, carries out dextrose tolerance test; Select impaired glucose tolerance rat to feed with Prof. Du Yucang high-calorie feed, continue nursing 2 months.

The preparation of diabetic mouse model: get Kunming mouse, fasting 10h, then tail vein injection alloxan 100mg/kg, gets blood from mouse orbit after 72h, surveys blood glucose value; Blood glucose value is modeling success more than 11.0mmol/L person, for later experiment.

1_6 observation index and method: body weight: weigh with the electronic scale that Sartorius (Germany) produces.Blood sugar: GOD-PAP method.Serum triglyceride: GPO-PAP method.Serum cholesterol: CH013-PAP method.Above 3 indexs, all by the operation of medicine box description, are produced EPPENDORF-F6124 type semi-automatic biochemical analyzer with Germany and are measured.Serum insulin is with putting the method for exempting from, and by specification operates.

1.7 data processings: experimental data represents with-X ± S, data statistics validity adopts t inspection.

2 experimental results

2.1 the present invention are on the impact of normal mouse blood sugar: get mouse 30, random point 3 groups: normal group, of the present invention group (5g/kg) and Glipizide group (1.3mg/kg).The morning every day gastric infusion, continuous 14d, fasting 6h after last administration, in mouse orbit get blood survey blood sugar.Result shows, the present invention has hypoglycemic activity (P > 0.05) to normal mouse.In table 1.

Table 1 the present invention is on the impact of normal mouse blood sugar.(x±s)

Group	N	Blood sugar mmol/L
			Normal group	10	6.21±1.34
Of the present invention group	10	5.33±1.18*
			Glipizide group	10	5.29±0.86**

Note: compare with normal group, * P > 0.05, * * P < 0.01

2.2 the present invention are on the impact of alloxan diabetes mouse: get normal mouse 10, survey its blood glucose value, feed with conventional feed.Separately get into mould mouse 50, be divided into 5 groups at random, be i.e. model group, of the present invention group (high, medium and low dosage group) and Glipizide group, successive administration 14d.Above 6 groups of mouse orbits are got blood, are surveyed its blood glucose value by 1h after last administration.

Result shows, give with alloxan after, model group compared with normal control group mice blood sugar level significantly raises, and still maintains higher level to experiment 14d its blood sugar.Of the present invention group of blood sugar level is starkly lower than model group, shows that the present invention can make alloxan diabetes mouse blood sugar reduce (P < 0.05), but still higher than Normal group (P < 0.05).In table 2.

Table 2 the present invention is on the impact (x ± s) of alloxan diabetes mouse blood sugar

Note: compare with normal group, * P < 0.05, * * * P < 0.01; Compare with model group, △ P < 0.05, △ △ △ P < 0.001

2.3 the present invention are to the effect of diabetic hyperlipemia rat

2.3.1 the present invention is on the impact of diabetic hyperlipemia rat body weight: grouping, administration is the same, day administration 1 time, continuous gavage 30 days.Experimental session drinking water for animals and feed without restriction.

Result shows, model group body weight is apparently higher than normal group (P < O.01), of the present invention group and Glipizide group body weight are starkly lower than model group (P < 0.01, P < 0.05), of the present invention group and Glipizide group compare indifference (P > 0.05, P > 0.05) with normal group.Illustrate that the present invention has the effect of certain reduction rat model body weight.In table 3.

Table 3 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat body weight

Group

N

Dose

Body weight (g)

Normal group	10	--	246.00±15.84
				Model group	10	--	316.5±18.31**
Of the present invention group (low)	10	5g/kg	285.64±15.31△
				Of the present invention group (in)	10	10g/kg	281.26±18.31△△
Of the present invention group (height)	10	15g/kg	271.48±17.42△△
				Glipizide group	10	1.3mg/kg	271.67±19.65△

Note: compare with normal group, * * P < 0.01; △ P < 0.05, △ △ P < 0.01 is compared with model group

2.3.2 the present invention is on the impact of diabetic hyperlipemia rat glucose tolerance: grouping is the same with administration.Rat Fast 8h, intraperitoneal injection 1.11mol/L glucose solution 2g/kg, docking is got blood and is surveyed (0), 30,60 and 120min blood glucose value at once.Check through t, model group IGT (compares with 120min at once, P < 0.05), Analysis of variance, this group 30,60 and 120min blood sugar are apparently higher than normal group (P < 0.001, P < 0.01 and P < 0.05).Of the present invention group 30 and 60min are significantly higher than normal group (P < 0.001, P < 0.01), but be also starkly lower than model group (P < 0.01, P < 0.05), and normal glucose tolerance (at once comparing with 120min, P > 0.05).In table 4.

Table 4 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat glucose tolerance

Note: compare with normal group, * P < 0.05, * * P < 0.01, * * * P < 0.001; Compare with model group, △ P < 0.05, △ △ P < 0.01; At once compare with this group, ▲ P < 0.05.

2.3.3 the present invention is on the impact of diabetic hyperlipemia rat blood serum triglycerides, cholesterol: grouping, administration is the same.Result shows, the obvious rising of model group serum triglyceride, cholesterol and normal group (P < 0.001, P < 0.001); Two places soup is respectively organized all higher than normal group (P < 0.01, P < 0.001), but is starkly lower than model group (P < 0.001, P < 0.001); Glipizide is all apparently higher than control group (P < 0.001, P < 0.001), but no significant difference (P > 0.05, P > 0.05) is compared with model group.Illustrate that the present invention has certain reduction serum triglyceride, the effect of cholesterol, row pyrazine does not but have this to act on.In table 5.

Table 5 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat blood serum triglycerides, cholesterol

Note: compare with normal group, * P < 0.01, * * P < 0.001; Compare with model group, △ P < 0.001

2.3.4 the present invention is on the impact of diabetic hyperlipemia rat blood serum insulin: grouping, administration is the same.Result shows, model group serum insulin is apparently higher than normal group (P < 0.01); The present invention respectively organizes and is starkly lower than model group (P < 0.05 with Glipizide group, P < 0.05), but also higher than normal group (P < 0.05, P < 0.05).Illustrate that the present invention has the effect of certain reduction serum insulin, this effect is similar to Glipizide.In table 6.

Table 6 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat blood serum insulin

Group	N	Dose	Insulin μ IU/ml
				Normal group	10	--	22.84±2.42
Model group	10	--	28.11±2.41**
				Of the present invention group (low)	10	5g/kg	25.58±1.33*△
Of the present invention group (low)	10	10g/kg	24.24±1.64*△
				Of the present invention group (low)	10	15g/kg	23.12±1.32*△
Glipizide group	10	1.3mg/kg	24.06±1.48*△

Note: compare with normal group, * P < 0.01, * * P < 0.001; Compare with model group, △ P < 0.005

Experiment shows that the present invention obviously can reduce blood glucose in diabetic mice, but the blood sugar level of intact animal is not affected, its hypoglycemic mechanism has nothing to do with directly stimulating the effect of B cell excreting insulin, the damage of B cell may be alleviated with it, recover the impaired 26S Proteasome Structure and Function of pancreas islet and pass through relevant to glycometabolic adjustment.Also can reduce Peripheral Blood insulin level simultaneously, improve the ubiquitous feature of this diabetes B of insulin resistance.In addition, the present invention can alleviate the body weight of diabetes B rat, presses down the generation that resistance is fat, makes body weight can control, in normal scope, to reduce the hyperlipidemia that diabetes occur together.

Along with the life style of people, the change of working environment, the age distribution of high blood pressure is tending towards becoming younger, and normal with hyperlipidemia, and blood viscosity increases, cardio cerebrovascular affection etc.Hypertension with traditional Chinese Medical card class constantly changes, and finds that liver-Yang sthenia type hypertension is more and more higher at the happy disease rates of high blood, or develops into hypertensive Etiological.Along with going deep into of research, find that the etiology and pathogenesis of high blood pressure is with liver-yang hyperactivity, it is main that card is contained in the wet heap soil or fertilizer over and around the roots of phlegm. liver-yang hyperactivity occupies very important status in high blood pressure and complication morbidity, the present invention's drink is natural traditional Chinese medicine, be conceived to overall conditioning, be conducive to the treatment rate and the controlling of blood pressure rate that improve high blood pressure, increase the compliance of patient.

Chinese medicine can play assistant hypoglycemic step-down, lipopenicillinase, reduces Western medicine side effect, and reduce Western medicine intake, the effect of consolidate curative effect, as the health-care effect that health products supplemental treatment has had.In a word, though Chinese medicine hypoglycemic hypotensive effect does not have, Western medicine speed is fast, effect is strong, and more its effect harrows a little; while step-down, diabetes, other pathology links hypertensive can also be taken into account, have improve microcirculation, lipopenicillinase is anti-oxidant; protection endothelium, regulates the effects such as vaso-active substance.Therefore, Chinese medicine obviously can improve diabetes, hypertensive clinical symptoms, improves the quality of life of patient.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.Folium Apocyni Veneti is cold in nature. and taste is sweet, bitter, and flat liver is calmed the nerves, clearing away heat and promoting diuresis.Main component rutin sophorin, catechu rope, isoquercitrin rope, glutamic acid, alanine, valine, potassium chloride etc., wherein antihypertensive compositions is Quercetin, general flavone, have hypotensive, strengthen capillary resistance, reduce capillary fragility, fall that blood refers to, coronary artery dilator increases coronary blood flow effect.The micro-bitter glycol of the present invention; Add some promoting blood circulation and removing blood stasis, mouthfeel is light, makes people be easy to the Chinese medicine accepted, can reach effect of hypoglycemic preferably.

Claims (10)

1. the Folium Apocyni Veneti health protection tea of a hypoglycemic, it is characterized in that, described Folium Apocyni Veneti health protection tea comprises the raw material of following parts by weight: Folium Apocyni Veneti 10 ~ 50 parts, rhizoma alismatis 10 ~ 20 parts, motherwort 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, cassia seed 10 ~ 20 parts, Canton love-pea vine 10 ~ 20 parts, hawthorn 10 ~ 20 parts, 10 ~ 20 parts, turmeric, cape jasmine 10 ~ 20 parts, parasitic loranthus 10 ~ 20 parts, 10 ~ 20 parts, sophora flower, the fruit of glossy privet 10 ~ 20 parts, polygala root 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, selfheal 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, the root of herbaceous peony 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts.

2. the Folium Apocyni Veneti health protection tea of hypoglycemic according to claim 1, it is characterized in that, in described Folium Apocyni Veneti health protection tea, the parts by weight of various raw material are: Folium Apocyni Veneti 10 ~ 40 parts, rhizoma alismatis 10 ~ 15 parts, motherwort 10 ~ 15 parts, giant knotweed 10 ~ 15 parts, cassia seed 10 ~ 15 parts, Canton love-pea vine 10 ~ 15 parts, hawthorn 10 ~ 15 parts, 10 ~ 15 parts, turmeric, cape jasmine 10 ~ 15 parts, parasitic loranthus 10 ~ 20 parts, 10 ~ 20 parts, sophora flower, the fruit of glossy privet 10 ~ 20 parts, polygala root 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, selfheal 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, the root of herbaceous peony 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts.

3. the Folium Apocyni Veneti health protection tea of described hypoglycemic according to claim 1, it is characterized in that, in described Folium Apocyni Veneti health protection tea, the parts by weight of various raw material are: Folium Apocyni Veneti 10 ~ 30 parts, rhizoma alismatis 10 ~ 20 parts, motherwort 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, cassia seed 10 ~ 20 parts, Canton love-pea vine 10 ~ 20 parts, hawthorn 10 ~ 20 parts, 10 ~ 20 parts, turmeric, cape jasmine 10 ~ 20 parts, parasitic loranthus 10 ~ 15 parts, 10 ~ 15 parts, sophora flower, the fruit of glossy privet 10 ~ 15 parts, polygala root 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, selfheal 10 ~ 15 parts, 10 ~ 15 parts, lotus leaf, the root of herbaceous peony 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts.

4. the preparation method of the Folium Apocyni Veneti health protection tea of hypoglycemic as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described Folium Apocyni Veneti health protection tea comprises following aspect:

A. Folium Apocyni Veneti harvesting, knead, Titian;

B. heat extraction 2 times by all the other raw material soaking ethanol described, dregs of a decoction extracting in water 2 times again, merges;

C. the concentrate concentrated extract of all the other raw materials is become medicinal extract, add honey or dextrin makes granule, pulvis or paste;

D. granule, pulvis or paste that the Folium Apocyni Veneti prepared and above-mentioned steps obtain are mixed, pack after ultraviolet sterilization.

5. the preparation method of the Folium Apocyni Veneti health protection tea of hypoglycemic according to claim 4, is characterized in that, in described step a, at annual harvesting in summer Folium Apocyni Veneti, plucked to spread out and shone or dry, sieve discarding stalk, raises clean impurity; First knead 10-15 minute with the little fire of iron pan, be then put into fragrance extracting machine Titian 10-20 minute.

6. the preparation method of the Folium Apocyni Veneti health protection tea of hypoglycemic according to claim 4, it is characterized in that, in described step b, all the other raw medicinal materials are mixed, steep in ethanol, soak more than 2 hours, add the alcohol extract 2 times of 8 times amount of Folium Apocyni Veneti gross weight, 6 times amount respectively, extraction time is 2 hours, 1 hour; Merge No. 2 extracts, extract is centrifugal by tubular type, obtains centrifugate, and centrifugate is crossed D 101 macroreticular resin and adsorbed, and first washes removal of impurities with water, then carries out wash-out with the ethanol of 70%, collects eluent, merges standing.

7. the preparation method of the Folium Apocyni Veneti health protection tea of hypoglycemic according to claim 4, is characterized in that, in described step c, above-mentioned steps is obtained extract, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, medicinal extract is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount; Paste after concentrated adds dextrin or granule made by honey.

8. the preparation method of the Folium Apocyni Veneti health protection tea of hypoglycemic according to any one of claims 1 to 3, it is characterized in that, the step that city pulvis prepared by other raw materials can also be:

A, get other raw materials and put into ethanol and soak, heat is extracted 3 times;

B, extract is positioned in inspissator concentrated, is then dried to pulvis.

9. the preparation method of the Folium Apocyni Veneti health protection tea of hypoglycemic according to claim 8, is characterized in that, in described step a, to be soaked by all the other bulk drugs in ethanol 12 hours, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds ethanol, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds ethanol again, and half an hour is boiled in third time heating, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, are condensed into pasty state.

10. the preparation method of the Folium Apocyni Veneti health protection tea of hypoglycemic according to claim 8, it is characterized in that, in described step b, by the raw material pasty state liquid extracted, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, by gained concentrate adjustment proportion to 1.46, decompression, the pasty state liquid after concentrated is put into drying machine and is dried to pulvis.