CN104839656A - Liver disease medical formula food - Google Patents

Abstract

The invention belongs to the technical field of medicinal and edible formulas and new resource foods, and particularly provides a medical formula food, a specific medical formula food or a non-specific medical formula food for patients with liver diseases to eat; the formula is prepared by reasonably mixing a plurality of traditional Chinese medicines with homology of medicine and food according to the requirements of special medical purpose formula food general rules, reasonably combining the physical characteristics of liver disease patients according to the essence theory of the traditional Chinese medicine, extracting essence of traditional Chinese medicine extract with dual purposes of medicine and food, a plurality of micro-encapsulated probiotics and short peptides, prebiotics, amino acids, carbohydrates, grease with health care function, a plurality of vitamins and mineral substances extracted by biological enzymolysis through a plurality of pre-hydrolysis SBE technologies, and the like, not only can be used as a single nutrient source to meet the nutritional requirements of the liver disease patients, but also has the effects of nourishing the liver, clearing heat, detoxifying, promoting blood circulation, removing blood stasis, harmonizing the liver and spleen, regulating qi to eliminate turbid, lowering adverse qi, stopping vomiting and preventing and treating liver diseases.

Description

Liver disease medical formula food

technical field

The invention belongs to the technical field of medicine and food homologous formula and new resource food, and specifically combines the traditional Chinese medicine essence theory of "medicine and food homologous Chinese medicine" with "multiple probiotics", and adds short peptides, prebiotics, Amino acids, carbohydrates, fats with health functions, multivitamins, and multiminerals are medical formulas for preventing and treating liver diseases, specific medical formulas or non-medical formulas.

Background technique

The cause of hepatitis is: 1. External factors include virus infection, such as hepatitis A virus, hepatitis B virus or hepatitis E virus, which invade the body from the outside, which is the most common external pathogenic factor; Metabolic organs will also be damaged; as the saying goes, "medicine is three-point poisonous", taking too many medicines, too complicated, and high doses, can cause inflammation if the liver cannot bear it; there are also things like drinking, heavy drinking, and long-term alcoholism The liver will also be damaged; 3. The liver itself can also cause inflammation of the liver due to immune disorders, so both internal and external factors can cause inflammation of the liver tissue and form hepatitis; these inflammations continue, and these damaging factors can't stop for a long time. Eliminate and develop slowly, leading to liver fibrosis, and finally to liver cirrhosis, and even cancer; "medicine and food from the same source" is one of the most valuable contributions to human beings in original Chinese medicine; traditional Chinese medicine has always emphasized "drug therapy It is not as good as diet therapy", diet therapy has become the best choice for modern people to pursue a return to nature and a healthy diet; it allows people to get rid of pain in the process of enjoying delicious food, and avoids the pain of injections, medicines, and even surgery;

For special nutritional food, there are corresponding regulations and development and application in developed countries such as the United States and the European Union; while my country's GB29922-2013 "General Rules for Formula Foods for Special Medical Purposes" national food safety standard Chinese medicine food clearly stipulates: 2.1.1 Medical formula food : Formula food for special medical purpose that can be used as a single source of nutrition to meet the nutritional needs of the target population; 2.1.2 Formula food for specific medicine: formula food for special medical purpose that can be used as a single source of nutrition to meet the nutritional needs of the target population under specific diseases or medical conditions;

Traditional Chinese medicine believes that: "The spleen (i.e. the digestive system) is the foundation of the day after tomorrow", gastrointestinal health is the foundation of health, 99% of human nutrition needs to be absorbed by the intestines, and intestinal diseases are also the source of all diseases; , the proportion of beneficial bacteria (probiotics) in the intestinal tract gradually decreases; for example, bifidobacteria account for 98% in infants and young children, drop to 10% in middle age, and only 5% after the age of 65; the older the person, the more probiotics less, the intestinal function will gradually decline. More and more studies have shown that the normal flora plays many irreplaceable roles in human digestion, immunity and disease resistance; changes in the composition of intestinal flora are associated with various diseases , especially the occurrence and development of intestinal diseases are closely related, and it has been found from existing clinical studies that probiotics can regulate intestinal flora and control intestinal inflammation, which is a safe and effective intervention regulation method.

The connection between the intestinal micro-ecosystem and the liver: the liver is the largest glandular organ in the human body, and 80% of its blood supply comes from the portal vein. Metabolites, trace amounts of intestinal-derived endotoxins and intestinal translocated bacteria, and various biological functions of the liver are closely related to the intestinal flora. Foreign bacteria (pathogenic bacteria) have an inhibitory effect. Free bile acids regulate the balance of intestinal flora by adjusting the pH value in the large intestine. Bifidobacteria and other acidic metabolites such as acetic acid and butyric acid participate in the energy metabolism of the host through the transformation of the liver; intestinal beneficial bacteria can also reduce intestinal The growth of ammonia-producing and urease-producing bacteria can use ammonia as a nitrogen source to synthesize proteins and reduce the detoxification load of the liver; in addition, a large number of pro-inflammatory cytokines and intestinal-derived endotoxins released by the intestinal immune response can enter the liver through the portal vein , activate liver immune cells such as Kupffer cells, etc., release a series of inflammatory mediators, and further affect the intestinal mucosa and distant tissues and organs; it can be seen that various biological functions of the liver are closely related to the normal micro-ecological environment of the intestinal tract contact.

Although direct oral administration of probiotics has a certain effect, but because probiotics cannot colonize in the intestinal tract, and stay and occupy very little space, they are easy to be lost, and harmful bacteria are easy to recur after stopping taking them. Related patients need to take them for a long time, and the treatment cycle is long. The postoperative recurrence rate is very high; in order to shorten the treatment cycle of related patients and reduce the recurrence rate after drug withdrawal, our team has made great efforts to improve the mechanism of probiotic colonization in the intestine through the key technical research on the mechanism of probiotic colonization in the intestine in the past three years. "Medicine and food homologous traditional Chinese medicine" compound, taking into account several key elements of probiotic colonization in the intestine: the presence of prebiotics can play a role in colonization, the reduction of intestinal pH environment and the improvement of intestinal adhesion of probiotic cells ability, etc., based on the above elements, the research group screened suitable ingredients from dozens of "Chinese medicines with the same origin of medicine and food", and discovered for the first time that the ingredients with the same origin of medicine and food, such as yam, barley, gallinaceous gold, Gorgon fruit and inulin, etc. Extracts of traditional Chinese medicine ingredients, stachyose, yeast, L-glutamine, etc., have a strong colonization effect on exogenous probiotics, providing an experimental basis for the selection of probiotics in intestinal microecological preparations;

At present, there are food-derived short peptides as the main raw material in the market, adding medicinal and edible mushrooms, tangerine peel, wolfberry, yam, Poria cocos, sealwort extracts, compound vitamins and minerals to form a compound formula, and the use of probiotics Bacteria as the main raw material, but it has not been found to combine the physical characteristics of patients with liver disease. According to the essence theory of traditional Chinese medicine, it varies from person to person. The golden combination uses more than ten kinds of Chinese medicine extract essences for both medicine and food, and a variety of probiotics. , prebiotics as the main raw materials, medical formula food, specific medical formula food or similar products made of short peptides, amino acids, carbohydrates, fats with health functions, multivitamins, and compound minerals.

purpose of invention

The purpose of the present invention is to creatively combine various anti-hepatitis probiotics with the extracts of the "medicine and food homologous Chinese medicine" compound, and add short peptides, amino acids, and carbohydrates , oils with health care functions, multivitamins, and multiminerals are used as auxiliary materials, which can not only supplement the necessary nutrients for patients with liver diseases, improve the nutritional status of the body, but also use the functional factors in the dual-purpose Chinese herbal medicine to regulate body functions. Probiotics can It is a medical formula food, a specific medical formula food or a non-medical formula food that can regulate the intestinal flora, has few toxic and side effects, is safe and effective, and is easily accepted by people and is suitable for liver disease patients.

Invention content:

In accordance with the requirements of the "General Rules for Formulated Foods for Special Medical Purposes", combined with the physical characteristics of patients with liver disease, and comprehensive research results in advanced physiology, medicine, nutrition and clinical application of Harvard University in the United States, the research and development team is based on "replenishing while eliminating", The quintessence theory of traditional Chinese medicine of "balanced care" (the liver, spleen, and kidney are the main principle), using one or several medicinal and edible Chinese medicine extracts and new resource foods, a variety of probiotics, short-term Peptides and prebiotics are the main raw materials, and amino acids, carbohydrates, oils with health care functions, multivitamins, and multimineral supplementary materials can not only meet the nutritional needs of patients with liver disease as a single source of nutrition, but also nourish the liver and liver, clear away heat and detoxify, Medical formula food, specific medical formula food or non-medical formula food (combined compound formula) that promotes blood circulation and removes blood stasis, harmonizes liver and spleen, regulates qi and transforms turbidity, relieves nausea and prevents liver disease;

1. The main components of the formula of the present invention are:

According to the physical characteristics of patients with liver disease, the Chinese medicine extract is based on the principle of the coordination of the liver, spleen and kidney in the theory of traditional Chinese medicine, and uses the functional factors in the medicinal and edible Chinese herbal medicine to regulate the body's function and prevent liver disease, and select the following major types of drugs Compatibility; among them: Nourishing liver and kidney: Cordyceps sinensis, Cordyceps militaris, Dendrobium, Ganoderma lucidum, Polygonatum, Propolis, Lycium barbarum, Black plum; Heat-clearing and detoxifying: Gardenia, dandelion, purslane, Hovenia dulcis, Cassia seed, black sesame, black soybean; Soothing the liver and invigorating the spleen: Guya, malt, hawthorn, kudzu root, mint, bergamot, coix seed, poria cocos, yam, gorgon, lotus seeds;

The medicinal and edible Chinese medicine extract of the present invention refers to Cordyceps sinensis (Cordyceps sinensis mycelium), Dendrobium, Ganoderma lucidum, Cordyceps militaris, Polygonatum, propolis, ebony, gardenia, dandelion, purslane, Hovenia dulcis, Semen cassia , black sesame, black beans, grain sprouts, malt, hawthorn, kudzu root, mint, bergamot, coix seed, gorgon, lotus seeds, hangbai chrysanthemum, magnolia officinalis, green plum, toi dai, bergamot, lentils, gorse , Eucommia male flowers, Snake-toothed snake grape leaves, Euglena, Danfeng peony flowers, Cyclocarya caraliens leaves, Moringa leaves, narrow baseline pattern fragrant tea vegetables, and Cantonese Cordyceps , using biological enzymes Hydrolyzed or pre-hydrolyzed SBE extracted and microencapsulated, spray-dried and freeze-dried extracts are all mixed;

2. A variety of probiotics: Most of the probiotics can reach the intestinal tract through the strong acid environment of the stomach to promote the proliferation of probiotics, adjust the micro-ecological balance in the intestine, promote the absorption of trace elements, enhance the motility function of the spleen and stomach, and accelerate the Efficient absorption, improving the balance of microbiota or enzymes on the mucosal surface, or stimulating the body's specific or non-specific immune mechanism, improving the body's colonization resistance or immunity; In rats, it can significantly reduce the level of intestinal-derived endotoxemia and prevent the occurrence of liver damage; selective intestinal decontamination is also an important measure to adjust the intestinal microecology. Some studies have applied the intestinal non-absorbable antibiotic rifaximin (rifaximin), prevents the occurrence of hepatic encephalopathy by inhibiting the growth of urease and ammonia-producing bacteria in the intestine;

Various probiotics described in the present invention all adopt the probiotics after microencapsulation, and its described probiotics are: wherein one, several or all of Bifidobacterium, Lactobacillus, Streptococcus thermophilus, Pediococcus lactis mix;

a The bifidobacterium above refers to: Bifidobacterium adolescentis, Bifidobacterium lactis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Bifidobacterium animal (Bifidobacterium lactis) ;

The Lactobacillus above refers to: Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus bulgaricus, Lactobacillus delbrueckii subspecies, Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus , Lactobacillus reuteri, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus crispatus, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus reuteri;

3. Short peptides: oligopeptides, which refer to a class of small molecular proteins that are isolated and extracted from animal or plant proteins by bio-enzyme engineering technology. The average molecular weight is below 1000Dalton, easily soluble in water, and stable to acid and heat. , can be directly absorbed without digestion, has high bioavailability, and is superior to free amino acids and complete proteins in absorption and utilization. It can be used in protein supplement foods, especially for people with low digestion and absorption capabilities. Short peptides are Excellent nitrogen source. In addition to nutritional functions, short peptides also have a series of physiologically active functions: improving digestion and absorption of the small intestine, enhancing immunity, anti-oxidation, assisting in regulating blood sugar, assisting in regulating blood lipids, assisting in lowering blood pressure, and anti-aging. Radiation, to promote mineral absorption, to enhance the effect of functional factors in Chinese herbal medicines;

The short peptide in the present invention refers to one, several or all of corn oligopeptides, wheat oligopeptides, marine collagen peptides, marine bone peptides, soybean protein peptides, whey protein peptides, and ovalbumin peptides;

4. Prebiotics: to promote intestinal colonization of probiotics, intestinal convergence, reduce intestinal pH environment, and not be used by most intestinal spoilage bacteria, but can promote beneficial bacteria in the human body - Lactobacillus, Bifidobacteria growth and reproduction, which can inhibit the growth of spoilage bacteria, and help to improve and maintain the normal function of the intestinal tract; long-term consumption can delay aging, laxative, improve immunity, reduce the burden on the liver, improve the absorption rate of nutrients, especially to improve the body Absorption of calcium, iron, zinc and other metal ions; it can selectively promote the growth and reproduction of beneficial bacteria (bifido, lactic acid), and can also be metabolized into acidic products such as lactic acid and other organic acids, reducing the pH value in the colon and inhibiting The growth of harmful bacteria in the intestinal tract; make the water and electrolyte in the small intestine stay in the intestinal cavity, produce a hypertonic effect, stimulate intestinal peristalsis and cause laxative, thereby promoting the discharge of intestinal toxins and other toxic substances, lactulose can also directly inactivate intestinal It has been widely used in the treatment of hepatic encephalopathy;

The prebiotics described in the present invention are of two types

a. Exogenous probiotics have a strong colonization effect. Prebiotics: extracts of yam, Poria cocos, barley, gallinacea, Gorgon, inulin;

b. Ordinary prebiotics: isomaltooligosaccharide, fructooligosaccharide, trehalose, soybean oligosaccharide, xylooligosaccharide, raffinose oligosaccharide, stachyose, yeast;

The prebiotics described in the present invention are: Chinese yam, poria cocos, coix seed, gallinacea, Gorgon fruit, extract of inulin, cottonseed oligosaccharide, stachyose, yeast, isomaltooligosaccharide, trehalose, fructooligosaccharide , soybean oligosaccharides, xylooligosaccharides, one, several or all mixed;

5. Carbohydrates: Carbohydrates are composed of three elements: carbon, hydrogen and oxygen. It is the cheapest nutrient among the three main nutrients that provide heat energy for the human body. Energy, avoid using precious protein to provide energy, carbohydrates are also important components of glycoproteins in cell membranes, glycolipids in nerve tissues, and deoxyribonucleic acid (DNA) that transmits genetic information, and glycogen contained in carbohydrates, When it is fully stored in the liver, the liver cells have a strong ability to detoxify certain toxic chemicals and toxins produced by various pathogenic microorganisms;

The carbohydrates described in the present invention refer to L-arabinose, fructose, mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast β-glucan, polyfructose, galactose, lactose, glucose, maltose, carbohydrate One, several or all of compounds, fats with health functions, starch, and glycogen are mixed;

6. The oil and ester with health care function means that it has a health care effect on the human body and can increase the energy of the final product, so that the energy contained in every 100g of the final product of the present invention should not be less than 295kJ (70kcal); It can also prevent arteriosclerosis, stroke and heart disease. Fish oil is effective for hypertension, coronary heart disease, stroke, diabetes, rheumatoid arthritis, cancer and other diseases; linseed oil has the effects of losing weight, lowering cholesterol, and improving kidney function; peony seed oil can lower blood fat and blood pressure, and enhance autoimmunity , prevent diabetes and prevent cancer; samara oil has the effect of preventing and treating hypertension, hyperlipidemia, vascular sclerosis and other diseases;

The fats and oils with health care function described in the present invention refer to linseed oil, peony seed oil, samara oil, milk thistle seed oil, phytosterol ester, royal rice oil, tea seed oil, fish oil, fish oil extract, peanut four Alkenic acid oil, sucrose polyester, DHA algae oil, krill oil, Suaeda salsa seed oil, saponica fruit oil, salina fruit oil, medium-chain triglycerides, yellow gelatin, eucalyptus fruit oil, Long handle almond oil, medium and long chain fatty acid edible oil, ingot maple seed oil, epigallocatechin gallate, diglyceride oil, lutein ester, one, several or all mixed;

7. Amino acid: divided into essential amino acid and non-essential amino acid, which is the basic unit of protein, endows protein with specific molecular structure and form, and makes it biochemically active; intake of appropriate amount of methionine is helpful for the metabolism of various sulfur-containing compounds in the human body And the methyl group contained in it can detoxify toxic substances or drugs through methylation; leucine can repair muscles, control blood sugar, and provide energy to body tissues; the essential amino acid phenylalanine can inhibit cancer growth, and can reduce the toxic and side effects of drugs, lysine can improve the absorption and utilization of food protein, achieve balanced nutrition, and promote growth and development; arginine helps to convert ammonia in the blood into urea and excrete it; for high Ammoniaemia, liver dysfunction, etc. are effective; histidine reduces the acidity of gastric juice, relieves the pain of gastrointestinal surgery, relieves vomiting during pregnancy and stomach burning sensation, inhibits digestive tract ulcers caused by autonomic nervous tension, and is effective for allergies Diseases, such as asthma, are also effective; tryptophan can prevent pellagra, depression, improve sleep and regulate mood;

Amino acids in the present invention refer to L-glutamine, γ-aminobutyric acid, pearl peptide powder, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histamine Acid, tryptophan, citrulline, ornithine, taurine, one, several or all mixed;

8. Vitamins and minerals: vitamins and minerals are essential nutrients for the human body, and the vitamins added in the present invention are vitamins and minerals are essential nutrients for the human body;

The vitamins added in the present invention are vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin Be, vitamin Bu, niacin, folic acid, pantothenic acid, One, several or all of choline and biotin are mixed;

The minerals added in the present invention are calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum, one, several or all of them mixed. The mineral is added as an organic or inorganic compound of the mineral;

The amount of added vitamins and minerals in the present invention is implemented with reference to the "General Rules for Formulated Foods for Special Medical Purposes". Now taking 1000g of finished products as an example, the added amounts are 0.01g of vitamin A, 0.000015g of vitamin D, 0.12g of vitamin E, 0.0075g of vitamin K, Vitamin K10.00001g, vitamin C10.625g, vitamin B10.016g, vitamin B20.016g, vitamin B60.015g, vitamin B0.0023g, vitamin Be, vitamin Bu, niacin 0.2g, folic acid 0.003g, pantothenic acid 0.051g, bile Alkali 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, Iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g;

The present invention integrates microcapsules, biological enzymolysis, pre-hydrolysis SBE, spray drying and freeze-drying to form the key technology of industrial production; microencapsulation protection technology effectively solves the problem of high temperature and strong acid gastric juice in the process of oral administration. inactivation; use the three-layer protein deep-buried microcapsule technology, and then mix it with the traditional Chinese medicine extract extracted and microencapsulated by biological enzymatic hydrolysis or pre-hydrolysis SBE technology to solve the problem of "multiple probiotics" and "medicine and food". The problem of coexistence of the components of the "homologous traditional Chinese medicine" has a certain resistance to high temperature and strong acid properties, which is conducive to the smooth passage of probiotics through the gastric juice to the intestinal tract through oral administration, so that the efficacy of the product in preventing and treating liver diseases is greatly improved compared with similar products in the market;

9. Use the above-mentioned integrated innovative technology to mix various ingredients evenly to make powdered solid beverages and granules, and pack them into 10g/bags, dissolve them in about 150ml warm water (45 degrees), drink them directly or take them through nasal feeding It can also be made into capsules and tablets by adding appropriate amount of supplementary materials or adding sweeteners and black sesame powder to make biscuits and other quick and convenient food, which is convenient to carry and eat when going out. If it is made into a beverage, spray drying is omitted and less auxiliary materials are added etc., divided into 10-65ml/bottle, drink one bottle every morning, noon, and 0.5 hours after dinner, and all operations are carried out in a clean and dry environment that meets the requirements of "Good Manufacturing Practice for Formula Foods for Special Medical Purposes";

The characteristics of this formula medical formula food and its effect on the body are mainly manifested in the following aspects:

1. This invention is developed according to the requirements of "General Rules for Formulated Foods for Special Medical Purposes", combined with the physical characteristics of patients with liver diseases, and comprehensive research results of advanced physiology, medicine, nutrition and clinical application of Harvard University in the United States, and it varies from person to person , golden combination;

2. The present invention is based on the quintessence theory of traditional Chinese medicine (liver, spleen, and kidney are the main principle of the same coordination of the liver, spleen, and kidney) based on the essence of traditional Chinese medicine theory of "eliminating the middle and nourishing" and "balanced care", and adopts the essence of a variety of traditional Chinese medicine extracts for both medicine and food. A variety of probiotics as the main raw material, with prebiotics, carbohydrates, amino acids, oils with health care functions, multi-vitamins and minerals as auxiliary materials, the organic combination of various ingredients, the integration of various functions, and through the active ingredients The synergistic effect among them enhances the effect;

3. It has high absorbability. Using the formula of the present invention, the food prepared with appropriate proportions of various components will be in an isotonic state after being dissolved in a certain amount of water, and can quickly pass through the stomach to the small intestine, absorb quickly and completely, and can quickly Supplement the nutrition needed by patients with liver disease without increasing the burden on liver and kidney;

4. The formula of the present invention adopts the extracts of various medicinal and edible Chinese herbal medicines, and contains a variety of functional active ingredients, which not only increases the concentration of functional factors, reduces the intake of various impurities, and helps to reduce the burden on the liver and kidneys, it has It has the function of enhancing the body's resistance, nourishing the liver and kidney, clearing away heat and detoxification, promoting blood circulation and removing blood stasis, harmonizing the liver and spleen, regulating qi and transforming turbidity, lowering adverse flow and relieving vomiting, and preventing and treating liver diseases;

5. The probiotics contained in the formula of the present invention, a variety of probiotics can maintain the balance of normal bacterial flora in the intestinal tract, inhibit the growth of pathogenic bacteria, prevent gastrointestinal disorders, etc., synthesize vitamins and amino acids in the intestinal tract, and improve the body's response to calcium ions Lactobacillus can significantly increase the content of intestinal mucosal immunoglobulin A (SIgA), which can regulate the local immunity of the intestinal mucosa of the body, regulate the stomach, Intestinal microecology can improve the utilization rate of calcium, phosphorus and iron, promote the absorption of iron and vitamin D, produce vitamin K and vitamin B, and reduce the absorption of cholesterol;

6. The formula food of the present invention uses food-derived bioactive short peptides from various sources as the nitrogen source, because the short peptides can be absorbed without digestion, which is more conducive to the utilization of the body, and can effectively improve the negative nitrogen balance of patients with liver diseases. The derived short peptide can improve the structure and function of intestinal mucosal epithelial cells, and improve the absorption capacity of intestinal mucosa;

7. This formula adopts the achievements of our team in the past three years on the key technical research on the mechanism of probiotics colonization in the intestine, and improves the "Chinese medicine with the same source of medicine and food" compound formula that improves the colonization of probiotics in the intestine, combined with prebiotics The presence of the food can play a role in colonization, reduce the pH environment of the intestinal tract, and improve the intestinal adhesion ability of probiotic cells. Therefore, the composition of the food formula greatly enhances the colonization of exogenous probiotics;

8. The prebiotics contained in the formula of the present invention can inhibit the growth of spoilage bacteria by promoting the growth and reproduction of probiotics in the intestine, and at the same time form a protective barrier on the surface of the intestinal mucosa, which can resist the damage of intestinal spoilage bacteria to the intestinal mucosa , reduce the absorption of harmful substances in the intestines, promote intestinal peristalsis, accelerate the discharge of residual substances in the intestines, prevent constipation, and enhance the body's immunity by promoting the growth and reproduction of intestinal probiotics, short peptides and active polysaccharides and other biologically active substances have a synergistic effect;

9. The carbohydrates contained in the formula of the present invention are three main nutrients that provide heat energy for the human body. They can be oxidized rapidly in the body to provide energy in time, and avoid using valuable protein to provide energy. Carbohydrates are also glycoproteins of cell membranes, Glycolipids in nervous tissue and important components of deoxyribonucleic acid (DNA) that transmit genetic information, and glycogen contained in carbohydrates, when it is fully stored in the liver, liver cells are resistant to certain toxic chemicals and various The toxin produced by a pathogenic microorganism has a strong detoxification ability;

10. The oil with health-care function contained in the formula of the present invention not only has a health-care effect on the human body, but also provides the energy required for normal life for the human body, so that the energy contained in every 100g of the final product of the present invention should not be less than 295kJ (70kcal);

11. The amino acid contained in the formula of the present invention is the basic unit of protein, endows protein with specific molecular structure and form, makes it have biochemical activity, helps the metabolism of various sulfur-containing compounds in the human body and the formazan contained in it The base can detoxify toxic substances or drugs by methylating them. It can repair muscles, control blood sugar, and provide energy to body tissues. It can also improve the absorption and utilization of food protein, achieve balanced nutrition, and promote growth and development;

12. The formula food of the present invention contains a variety of vitamins and minerals, which can quickly supplement the micronutrients needed by patients with liver diseases. After the short peptide is chelated with calcium, iron, zinc, etc., the absorption rate of mineral elements is increased;

13. The formula of the present invention does not contain fat and cholesterol, and can not increase the intake of fat and cholesterol while supplementing protein and micronutrients, and avoids the adverse effects of high-protein foods such as meat and eggs.

Detailed ways

The present invention will be further described below through the following examples, which will help to understand the present invention.

Implementation Case 1

To achieve the purpose of the present invention, the liver disease medical formula food is based on the physical characteristics of liver disease patients, according to the essence theory of traditional Chinese medicine, and varies from person to person. Resource food, a variety of probiotics, short peptides as the main raw materials, medical formula food made of prebiotics, carbohydrates, amino acids, oils and fats with health functions, multivitamins, and various minerals as auxiliary materials;

Formulated according to the following raw materials and their dosages, medicinal and edible extracts and new resource foods: Cordyceps 12g, Dendrobium 12g, Ganoderma lucidum 11g, Cordyceps militaris 11g, Polygonatum 10g, Propolis 10g, Ume 9g, Gardenia 9g, Dandelion 8g , Purslane 8g, Hovenia dulcis 7g, Cassia 7g, Black sesame 7g, Black beans 7g, Guya 7g, Malt 7g, Hawthorn 7g, Pueraria 6g, Mint 6g, Bergamot 6g, Gorgon 6g, Lotus seeds 6g, Chrysanthemum 6g, Magnolia officinalis flower 5g, green plum blossom 5g, toitoi flower 5g, bergamot flower 5g, coix seed 5g, lentil 5g, line-leaf gorse 4g , eucommia male flower 4g , snake-toothed snake grape leaf 4g , euglena 3g, phoenix peony Flower 3g , Cyclocarya paliurus leaves 3g , Moringa oleifera leaves 2g , narrow base line grain fragrant tea vegetables 2g, Guangdong Cordyceps 1g , milk mineral salt 1g, various probiotics 300g, short peptides 200g, prebiotics 100g, various amino acids 100g , carbohydrates 100g, oils and esters with health care function 100g, vitamin A0.01g, vitamin D0.000015g, vitamin E0.12g, vitamin K0.0075g, vitamin K10.00001g, vitamin C10.625g, vitamin B10.016g, vitamin B20 .016g, vitamin B60.015g, vitamin B0.0023g, vitamin Be, vitamin Bu, niacin 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, Potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g;

When making it, Ganoderma lucidum, Cordyceps militaris, Polygonatum, propolis, black plum, gardenia, dandelion, purslane, Hovenia dulcis, cassia seed, grain sprouts, malt, hawthorn, mint, bergamot, coix seed, gorgon fruit, hangover White Chrysanthemum, Magnolia officinalis, Green Plum Blossom, Toi Toi Flower, Bergamot Flower, Gorse Leaf, Eucommia Male Flower, Snake-toothed Grape Leaf, Euglena, Danfeng Peony Flower, Cyclocarya Leaf, Moringa Leaf, Narrow Baseline After soaking Wenxiang tea vegetables , add β-cyclodextrin, extract by pre-hydrolysis SBE technology, and spray-dry the powdery substance, and then add Cordyceps sinensis, Cordyceps militaris, kudzu root, black sesame, and black beans extracted by biological enzymolysis , lotus seeds, lentils, Cordyceps sinensis (Cordyceps mycelium), Dendrobium, Cantonese Cordyceps, milk mineral salts, short peptides, prebiotics, amino acids, carbohydrates, oils with health care functions, multivitamins and minerals are crushed and mixed together Carry out pasteurization for 1 hour, then add microencapsulated bifidobacteria, lactobacilli, and streptococcus thermophilus and mix uniformly to make powdered solid drinks and granules, and pack them into 10g/bags, use about After dissolving in 150ml of warm water (45 degrees), drink it directly or take it through nasal feeding; you can also add appropriate amount of additives to make capsules, tablets, or add sweeteners and black sesame powder to make biscuits and other fast and convenient foods for easy travel. For consumption, if it is made into a beverage, spray drying is omitted, less auxiliary materials are added, and it is divided into 10-65ml/bottle, and one bottle is drunk each morning, noon, and 0.5 hours after dinner. All operations are in accordance with the "Special Medicine It is carried out in a clean and dry environment as required by the Good Manufacturing Practice for Formula Foods;

The production process of the present invention is the key technology of industrial production composed of microcapsules, biological enzymolysis, pre-hydrolysis SBE, spray drying and freeze-drying integration innovation; the microencapsulation protection technology effectively solves the problem of high temperature and strong acid gastric juice in the oral process. Inactivation of probiotics; use three-layer protein deep-buried microcapsule technology, and then mix evenly with traditional Chinese medicine extracts extracted by biological enzymatic hydrolysis or pre-hydrolysis SBE technology and microencapsulated to solve the problem of "multiple probiotics" and " The problem of the coexistence of the components of traditional Chinese medicine with the same origin of medicine and food has a certain resistance to high temperature and strong acid properties, which is conducive to the smooth passage of probiotics through gastric juice to the intestinal tract through oral administration, so that the efficacy of the product in preventing and treating liver diseases is significantly higher than that of similar products in the market improve.

Implementation Case 2

The above medical formula food for liver disease also includes the following components by weight, extracts for both medicine and food: 8g of dandelion, 8g of purslane, 7g of Hovenia dulcis, 7g of cassia seed, 7g of black sesame, 7g of black soybean, 7g of grain bud, 7g of malt, 7g of hawthorn, 6g of kudzu root, 6g of mint, 6g of bergamot, 6g of gorgon, 6g of lotus seed, 6g of chrysanthemum, 5g of Magnolia officinalis, 5g of green plum flower, 5g of tortoise flower, 5g of bergamot, 5g of coix seed, 5g of lentil, 4g of gorse flower , 4g of eucommia male flower, 4g of grape leaf , 3g of euglena, 3g of peony flower , 3g of willow leaf, 2g of moringa leaf , 2g of fragrant tea vegetable with narrow base line pattern , and guangdong cordyceps seed 1g , milk mineral salt 1g, prebiotics 350g, probiotics 300g, short peptides 150g, various amino acids 100g, carbohydrates 100g, oils and esters with health functions 100g, carbohydrates, oils with health functions, 50g, vitamins and minerals Substance 25g.

Implementation Case Three

The above-mentioned medical formula food for liver disease also includes the following components by weight: 400g of extracts of Chinese medicines for both medicine and food and new resource food, 350g of prebiotics, 350g of short peptides, 300g of carbohydrates, and 300g of oil with health care function , 100g of various amino acids, 25g of multivitamins and minerals; the energy contained in each 100g should not be less than 295kJ (70kcal).

Implementation Case 4

The above-mentioned specific medical formula food for liver diseases also includes the following components by weight: 700g of prebiotics, 500g of short peptides, 300g of carbohydrates, 300g of various probiotics, 100g of various amino acids, 25g of multivitamins and minerals; The energy contained should not be less than 295kJ (70kcal).

Implementation Case Five

The above medical formula food for liver diseases also includes the following components by weight: 500g of prebiotics, 350g of short peptides, 300g of carbohydrates, 250g of various probiotics, 100g of various amino acids, 25g of multivitamins and minerals; The energy should not be less than 295kJ (70kcal).

Implementation Case Six

The above-mentioned liver disease medical formula food also includes the following components by weight: 350g of short peptides, 350g of prebiotics, 300g of carbohydrates, 300g of oils and esters with health care functions, 100g of various amino acids, 25g of multivitamins and minerals; The energy contained should not be less than 295kJ (70kcal).

Claims (10)

1. Medical formula food for liver disease, which is characterized by combining the physical characteristics of liver disease patients, according to the essence theory of traditional Chinese medicine, which varies from person to person, and the golden compatibility is one, several or all of the extracts of traditional Chinese medicine for medicinal and edible purposes and new Resource food, a variety of probiotics, short peptides as the main raw materials, medical formula food made of prebiotics, carbohydrates, amino acids, oils with health functions, multi-vitamins, and multi-minerals as auxiliary materials; Formulated according to the following raw materials and their dosage, medicinal and edible extracts and new resource foods: Cordyceps sinensis 12g, Dendrobium 12g, Ganoderma lucidum 11g, Cordyceps militaris 11g, Polygonatum 10g, propolis 10g, ebony 9g, gardenia 9g, dandelion 8g , Purslane 8g, Hovenia dulcis 7g, Cassia 7g, Black sesame 7g, Black beans 7g, Guya 7g, Malt 7g, Hawthorn 7g, Pueraria 6g, Mint 6g, Bergamot 6g, Gorgon 6g, Lotus seeds 6g, Chrysanthemum 6g, Magnolia officinalis flower 5g, green plum blossom 5g, toitoi flower 5g, bergamot flower 5g, coix seed 5g, lentil 5g, line-leaf gorse 4g , eucommia male flower 4g , snake-toothed snake grape leaf 4g , euglena 3g, phoenix peony Flower 3g , Cyclocarya paliurus leaves 3g , Moringa oleifera leaves 2g , narrow base line grain fragrant tea vegetables 2g, Guangdong Cordyceps 1g , milk mineral salt 1g, various probiotics 300g, short peptides 200g, prebiotics 100g, various amino acids 100g , carbohydrates 100g, oils and esters with health care function 100g, vitamin A0.01g, vitamin D0.000015g, vitamin E0.12g, vitamin K0.0075g, vitamin K10.00001g, vitamin C10.625g, vitamin B10.016g, vitamin B20 .016g, vitamin B60.015g, vitamin B0.0023g, vitamin Be, vitamin Bu, niacin 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, Potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g; When making it, Ganoderma lucidum, Cordyceps militaris, Polygonatum, propolis, black plum, gardenia, dandelion, purslane, Hovenia dulcis, cassia seed, grain sprouts, malt, hawthorn, mint, bergamot, coix seed, gorgon fruit, hangover White Chrysanthemum, Magnolia officinalis, Green Plum Blossom, Toi Toi Flower, Bergamot Flower, Gorse Leaf, Eucommia Male Flower, Snake-toothed Grape Leaf, Euglena, Danfeng Peony Flower, Cyclocarya Leaf, Moringa Leaf, Narrow Baseline After soaking Wenxiang tea vegetables , add β-cyclodextrin, extract by pre-hydrolysis SBE technology, and spray-dry the powdery substance, and then add Cordyceps sinensis, Cordyceps militaris, kudzu root, black sesame, and black beans extracted by biological enzymolysis , lotus seeds, lentils, Cordyceps sinensis (Cordyceps mycelium), Dendrobium, Cantonese Cordyceps, milk mineral salts, short peptides, prebiotics, amino acids, carbohydrates, oils with health care functions, multivitamins and minerals are crushed and mixed together Carry out pasteurization for 1 hour, then add microencapsulated bifidobacteria, lactobacilli, and streptococcus thermophilus and mix uniformly to make powdered solid drinks and granules, and pack them into 10g/bags, use about After dissolving in 150ml of warm boiled water (45 degrees), drink directly or ingest through nasal feeding; you can also add appropriate amount of additives to make capsules, tablets, or add sweetener and black sesame powder to make biscuits and other fast and convenient food, which is easy to carry out For consumption, if it is made into a beverage, it will be spray-dried without adding auxiliary materials, etc., divided into 10-65ml/bottle, and drink 1 bottle each morning, noon, and 0.5 hours after dinner. All operations are in accordance with the "Special Medicine It is carried out in a clean and dry environment as required by the Good Manufacturing Practice for Formula Foods; The production process of the present invention is characterized by the integration and innovation of microcapsules, biological enzymolysis, pre-hydrolysis SBE, spray drying and freeze-drying, which constitute the key technology of industrial production; the microencapsulation protection technology effectively solves the problem of high temperature and Inactivation of probiotics by strong acid gastric juice; three-layer protein deep-buried microcapsule technology is used, and then mixed with traditional Chinese medicine extracts extracted by biological enzymatic hydrolysis or pre-hydrolysis SBE technology and microencapsulated to solve the problem of "multiple probiotics". The problem of coexistence with the components of "medicine and food homologous traditional Chinese medicine" has a certain resistance to high temperature and strong acid properties, which is conducive to the smooth passage of probiotics through gastric juice to the intestinal tract through oral administration, so that the efficacy of the product in preventing and treating liver diseases is comparable to that of similar products in the market significantly improved compared to . 2. The medical formula food for liver disease according to claim 1, characterized in that the herbal medicine extract and new resource food are: Ganoderma lucidum, Cordyceps militaris, Rhizoma Polygonatum, propolis, ebony, gardenia, dandelion, Purslane, Hovenia dulcis, Cassia, Guya, Malt, Hawthorn, Mint, Bergamot, Coix Seed, Gorgon Seed, Hangbai Chrysanthemum, Magnolia officinalis, Green Plum Blossom, Toi Toi Flower, Bergamot, Gorse, Eucommia After soaking male flowers, Snake dentata grape leaves, Euglena, Danfeng peony flowers, Cyclocarya paliurus leaves, Moringa oleifera leaves, and tea leaves with narrow base line pattern , add β-cyclodextrin, extract with pre-hydrolysis SBE technology, and The powdery substance prepared by spray-drying is added with bio-enzymatically extracted Cordyceps sinensis, Cordyceps militaris, kudzu root, black sesame, black beans, lotus seeds, lentils, Cordyceps sinensis (Cordyceps sinensis mycelium), Dendrobium, Guangdong Cordyceps, milk mineral salt one, several, or a mixture of all. 3. The liver disease medicine formula food according to claim 1, characterized in that it can be prepared into powder, granule, capsule, tablet and beverage food according to the formula. 4. The medical formula food for liver diseases according to claim 1, further comprising the following components by weight: 400g of extracts of Chinese medicines for both medicine and food and new resource food, 350g of prebiotics, 350g of short peptides, carbohydrates 300g of compound, 300g of oil with health care function, 100g of various amino acids, 25g of multivitamins and minerals; the energy contained in each 100g should not be less than 295 kJ (70 kcal). 5. The medical formula food for liver disease according to claim 1, characterized in that the probiotics are: Bifidobacterium, Lactobacillus, Streptococcus thermophilus, Pediococcus lactis, one of them, several or all mixed; The bifidobacterium above refers to: Bifidobacterium adolescentis, Bifidobacterium lactis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Bifidobacterium animal (Bifidobacterium lactis); The Lactobacillus above refers to: Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus , Lactobacillus reuteri, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus crispatus, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus reuteri. 6. The liver disease medical formula food according to claim 1, characterized in that the prebiotics are: the extraction mixture of Chinese yam, Poria cocos, Job's tears, gallinacea, Gorgon seed, inulin, raffinose oligosaccharides, trehalose , stachyose, yeast, isomaltooligosaccharides, fructooligosaccharides, soybean oligosaccharides, xylooligosaccharides, a mixture of several or all of them. 7. The liver disease medical formula food according to claim 1, characterized in that the amino acid is: L-glutamine, γ-aminobutyric acid, pearl peptide powder, methionine, isoleucine, tyrosine, A mixture of one, several or all of phenylalanine, lysine, arginine, histidine, tryptophan, citrulline, ornithine, and taurine. 8. The medical formula food for liver disease according to claim 1, characterized in that the carbohydrates described in the present invention refer to L-arabinose, fructose, mussel polysaccharide, resistant dextrin, shell Oligosaccharides, yeast β-glucan, polyfructose, galactose, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen, one, several or all mixed. 9. The liver disease medical formula food according to claim 1, wherein the described oil with health care function is: linseed oil, peony seed oil, samara oil, milk thistle seed oil, phytosterol ester, Royal rice oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, sucrose polyester, DHA algae oil, krill oil, Suaeda salsa seed oil, saponica fruit oil, arachidonica fruit oil, Medium chain triglycerides, yellow gelatin, eucalyptus fruit oil, almond oil, medium and long chain fatty acid edible oil, ingot maple seed oil, epigallocatechin gallate, diglyceride oil, lutein One, several or all of the esters are mixed. 10. The liver disease medical formula food according to claim 1, characterized in that the short peptide is: marine collagen peptide, corn oligopeptide, wheat oligopeptide, marine bone peptide, soybean protein peptide, whey protein One, several or all of peptides and ovalbumin peptides are mixed.