CN104338174B - Bleeding-stopping patch with composite structure and preparation method thereof - Google Patents
Bleeding-stopping patch with composite structure and preparation method thereof Download PDFInfo
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- CN104338174B CN104338174B CN201310342513.6A CN201310342513A CN104338174B CN 104338174 B CN104338174 B CN 104338174B CN 201310342513 A CN201310342513 A CN 201310342513A CN 104338174 B CN104338174 B CN 104338174B
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- layer
- cloth
- calcium alginate
- nonwoven layer
- hemostatic plaster
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- 239000002131 composite material Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 42
- 239000000648 calcium alginate Substances 0.000 claims abstract description 38
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 38
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 35
- 239000000835 fiber Substances 0.000 claims abstract description 23
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 9
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 9
- 239000002082 metal nanoparticle Substances 0.000 claims abstract description 5
- 230000002439 hemostatic effect Effects 0.000 claims description 28
- 239000011505 plaster Substances 0.000 claims description 25
- 239000004744 fabric Substances 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 12
- 238000010276 construction Methods 0.000 claims description 11
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 229920000742 Cotton Polymers 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229910052709 silver Inorganic materials 0.000 claims description 5
- 239000004332 silver Substances 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 3
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims description 2
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 2
- 229910001431 copper ion Inorganic materials 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 abstract description 21
- 239000011248 coating agent Substances 0.000 abstract description 5
- 238000000576 coating method Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 230000035876 healing Effects 0.000 abstract description 2
- 230000036407 pain Effects 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 15
- 208000027418 Wounds and injury Diseases 0.000 description 15
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 239000005020 polyethylene terephthalate Substances 0.000 description 4
- 241001311547 Patina Species 0.000 description 3
- 229920000297 Rayon Polymers 0.000 description 3
- 229920004933 Terylene® Polymers 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- -1 compound calcium alginate Chemical class 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229940100890 silver compound Drugs 0.000 description 3
- 150000003379 silver compounds Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910000765 intermetallic Inorganic materials 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the field of medical apparatuses, and concretely relates to a bleeding-stopping patch with a composite structure and a preparation method thereof. The bleeding-stopping patch comprises a mixed non-woven fabric layer of hydrophobic fiber and hydrophilic fiber, a calcium alginate non-woven fabric layer, and a metal-ion or metal-nanoparticle layer disposed on the composite non-woven fabric layer through coating. The bleeding-stopping patch has the effects of stopping bleeding, relieving pain, diminishing inflammation, keeping a moisture environment for a wound, promoting healing of the wound and the like.
Description
Technical field
The present invention relates to medicine equipment, and in particular to hemostatic plaster of composite construction and preparation method thereof.
Background technology
In daily Minimally Invasive Surgery wound hemostasis nursery work, generally created using the absorbent gauze application for being soaked with liquid
On mouth or in embedded wound, the effects such as hemostasis, analgesia, anti-inflammatory, the environment for keeping wound moistening, promotion Wound healing are played.
In the last few years, existing many patent documents and non-patent literature were disclosed or reported using calcium alginate henatischesis dressing, Nano Silver
Calcium alginate henatischesis dressing.
The advantage of calcium alginate henatischesis dressing is, in the fiber in calcium alginate non-woven fabrics and wound diffusate and blood
Sodium ion swap, discharge calcium ion, calcium ion can accelerate the formation of clot in capillary end.With absorption sodium
Ionic weight increases, and calcium alginate is gradually converted into being dissolved in the sodium alginate of water, and in wound surface thin layer of hydrogel is formed, can be with
The moistening of nerve endings is maintained, slows down the pain of patient, and also the healing for the surface of a wound creates a good microcirculation ring
Border, promotes wound to heal as early as possible.10-20 times up to own wt of the liquid absorption of calcium alginate non-woven fabrics.However, calcium alginate
Though non-woven fabrics has certain hemostatic function, without antibacterial ability, and its high cost, low intensity, fragility is big, not acid and alkali-resistance, affects
Its using effect.
The content of the invention
The invention provides a kind of hemostatic plaster of composite construction, it can reach hemostasis, analgesia, anti-inflammatory, holding wound
Moist environment, promote Wound healing etc. to act on, and treatment cost can be reduced, improve practicality.
The hemostatic plaster of the composite construction of the present invention, including composite non woven layer of cloth, and positioned at compound nonwoven cloth layer surface
On metal ion or metal nano-particle layer.In one embodiment, the composite non woven layer of cloth include hydrophobic fibre and
The hybrid nonwoven layer of cloth of hydrophilic fibre, and calcium alginate nonwoven layer, the hybrid nonwoven layer of cloth and calcium alginate nonwoven
Layer of cloth is combined with each other by processing adhesion.In another embodiment, the material of the hybrid nonwoven layer of cloth is viscous, bright and beautiful viscous to wash
Or polyester-cotton blend.In another embodiment, the metal ion is zinc ion, copper ion or silver ion.In another embodiment,
The metal nanoparticle is from nanometer silver paste.
The present invention also provides the preparation method of the hemostatic plaster of composite construction, comprises the following steps：（1）By washing for 1-2 layers
The hydrophobic fibres such as viscous/bright and beautiful viscous/polyester-cotton blend and hydrophilic fibre hybrid nonwoven layer of cloth, 1 layer of calcium alginate nonwoven layer overlay one
Rise, then by processing so as to which adhesion is combined with each other, and makes composite non woven layer of cloth；（2）In the table of above-mentioned composite non woven layer of cloth
Face（That is calcium alginate nonwoven layer）The liquid of upper spray metal ion or nanometer silver paste.In one embodiment, above-mentioned steps
（1）It is hydrophobic fibre and hydrophilic fibre to be mixed by being carded to net, then by non-woven fabrics made by needle point method.
Spraying technology is sub-micron grade by liquid refining, is then coated directly on calcium alginate nonwoven layer surface.It is due to coating
Miniaturization is to sub-micron grade even nano level liquid, it is possible to form sub-micron grade, nano grade membrane thickness and high accuracy shape
Into film；And liquid be with dispersion after state be directly coated with.
The calcium alginate fibre of the present invention has very strong haemostatic effect, and water soluble metallic compound is used as metal ion
Source.Without wishing to be bound by any theory, the metal ion of the present invention, nano-Ag particles have suction-operated, microorganism to microorganism
After by metal ion, nano-Ag particles absorption, play respiratory enzyme and just lose effect, and cell membrane, the cell membrane of microorganism
Will be destroyed, microorganism will be dead rapidly, so its sterilizing ability is especially strong.Hydrophobic fibre such as terylene, substantially
Component is PET, does not contain hydrophilic radical, durable, and elasticity is good.And hydrophilic fibre example
Such as viscose glue, containing hydrophilic radical, such as hydroxyl, degree of crystallinity is relatively low, with good hygroscopicity, can oozing out wound in time
Liquid absorbs, and dispels the potential place of bacterial growth.The use of hemostatic plaster can prevent the invasion of extraneous bacterium and interior boundary's wound from oozing
Go out the excessive of liquid and jeopardize other wounds.
Hemostatic plaster of the present invention is used for minimally invasive intervention operation puncturing wound hemostasis, using calcium alginate non-woven fabrics and other nothings
The compound of cloth is spun, intensity is high, and different fibre compositions respectively play hydrophobic and water suction effect in other non-woven fabrics, can in time by wound
The diffusate of mouth absorbs, and the potential place of bacterial growth is dispelled, while can prevent the invasion of extraneous bacterium and interior boundary's wound from oozing out
Liquid excessive and jeopardize other wounds.
Meanwhile, this compound calcium alginate hemostatic plaster due in calcium alginate nonwoven layer spraying with metal from
Son, nano-Ag particles, make it with hemostatic function, antibacterial functions, moisture-keeping functions, liquid suction function etc., and due to adopting marine alga
Sour calcium non-woven fabrics and wash viscous/brocade it is viscous/polyester-cotton blend is non-woven fabric compounded, can greatly improve the use fastness of hemostatic plaster so as to become one
Plant extremely excellent medical hemostatic paster.
Description of the drawings
In order to more clearly describe technical scheme, briefly introduce below in conjunction with accompanying drawing.It is clear that this
A little accompanying drawings are only some specific embodiments that the application is recorded.The present invention includes but is not limited to these accompanying drawings.
Fig. 1 is the hemostatic plaster of the present invention, wherein 1- calcium alginates nonwoven layer；2- washs bonded non-woven fabrics layer；3- patinas are closed
Thing.
Fig. 2 is the hemostatic plaster of the present invention, wherein 1- calcium alginates nonwoven layer；2- washs bonded non-woven fabrics layer；3- Nano Silvers.
Fig. 3 is the hemostatic plaster of the present invention, wherein 1- calcium alginates nonwoven layer；2- brocade bonded non-woven fabrics layers；3- patinas are closed
Thing
Fig. 4 is the hemostatic plaster of the present invention, wherein 1- calcium alginates nonwoven layer；2- polyester-cotton blend nonwoven layers；3- patinas are closed
Thing
Specific embodiment
For a further understanding of the present invention, the preferred version of the present invention is described below in conjunction with embodiment.These
Description is merely illustrative the feature and advantage of hemostatic plaster of the present invention, rather than limits the scope of the invention.
Embodiment 1
According to Fig. 1, the hemostatic plaster of the present invention washs bonded non-woven fabrics including 1-2 layers（2）With 1 layer of calcium alginate non-woven fabrics（1）,
Layer 2-3 non-woven fabrics is reinforced together by pinprick reinforcement method.Pinprick reinforcement method is using miniature needing machine, its primary structure bag
Include needle plate, trawl board, dial web plate, Needle Board density determines according to the needle handle diameter of pricker, needling density is fine according to reinforcing
Tie up length, fineness and reinforcing fastness to determine.Then silver compound solution is sprayed on calcium alginate nonwoven layer surface
（3）, silver ion is adsorbed on calcium alginate fibre.
Embodiment 2
It is similar with the method for embodiment 1, as shown in Fig. 2 nonwoven layer adopts terylene, viscose glue in the hemostatic plaster of the present invention
Hybrid nonwoven cloth and calcium alginate are non-woven fabric compounded, and coating adopts Nano Silver.
Embodiment 3
It is similar with the method for embodiment 1, as shown in figure 3, the hemostatic plaster nonwoven layer of the present invention is fine using polyamide fibre, viscose glue
Dimension hybrid nonwoven cloth and calcium alginate are non-woven fabric compounded, and coating adopts silver compound.
Embodiment 4
It is similar with the method for embodiment 1, as shown in figure 4, the hemostatic plaster nonwoven layer of the present invention adopts terylene, cotton fiber
Hybrid nonwoven cloth and calcium alginate are non-woven fabric compounded, and coating adopts silver compound.
The explanation of above example is only intended to the core concept for helping understand the present invention.It should be pointed out that for this area
Those of ordinary skill for, under the premise without departing from the principles of the invention, can also to the present invention hemostatic plaster and its system
Preparation Method carries out some improvement and modification, but these are improved and modification also falls into the scope that the claims in the present invention are claimed
It is interior.
Reference：
Patent document：
Application number 201110039947.X, denomination of invention：A kind of preparation method of medical calcium alginate filler strips；
Application number 201010017663.6, denomination of invention " a kind of preparation method of compound calcium alginate dressing "；
Application number 201010017666.X, denomination of invention " a kind of preparation method of biological calcium alginate antimicrobial dressing "；
Application number 201020022437.2, denomination of invention " a kind of preparation method of compound calcium alginate antiseptic dressing "；
Application number 200610053877.2, denomination of invention " nano silver calcium alginate antibacterial dressing "；
Application number 200510039299.2, denomination of invention " a kind of calcium alginate henatischesis dressing of superabsorbent and its preparation
Method "；
Application number 201110332357.6, " a kind of carrying silver ion calcium alginate fibre carries silver-colored medical non-woven to denomination of invention
The preparation method of cloth "；
Application number 96242391.2, denomination of invention " Application containing calcium alginate "；
Application number 96113181, denomination of invention " preparation method of calcium alginate application and its calcium alginate fibre non-woven fabrics "；
And
Non-patent literature：
《Nano-silver biological effect study is in progress》, Southeast China University's journal (natural science edition), on November 20th, 2009；
《The anti-microbial property research of silver ion anti-bacterial fibre》, hosiery industry, on April 28th, 2008；And
《The comparative study that two kinds of different medical dressing are infected abdominal operation incision》, Jilin University's Master's thesis, 2011
On October 1, in.
Claims (8)
1. a kind of hemostatic plaster of composite construction, including composite non woven layer of cloth, and the gold in compound nonwoven cloth layer surface
Category ion or metal nano-particle layer, wherein the compound nonwoven cloth layer includes the mixing nothing of hydrophobic fibre and hydrophilic fibre
Spin layer of cloth, and calcium alginate nonwoven layer.
2. the hemostatic plaster of the composite construction of claim 1, wherein the hybrid nonwoven layer of cloth leads to calcium alginate nonwoven layer
Cross processing adhesion to be combined with each other.
3. the hemostatic plaster of the composite construction of claim 1, the wherein material of hybrid nonwoven layer of cloth are to wash viscous, bright and beautiful viscous or polyester-cotton blend.
4. the hemostatic plaster of the composite construction of any one of claim 1-3, wherein metal ion be zinc ion, copper ion or silver from
Son.
5. the hemostatic plaster of the composite construction of any one of claim 1-3, wherein metal nanoparticle is from nanometer silver paste.
6. the preparation method of the hemostatic plaster of the composite construction of any one of claim 1-5, comprises the following steps：
(1) hydrophobic fibre of 1-2 layers and hydrophilic fibre hybrid nonwoven layer of cloth, 1 layer of calcium alginate nonwoven layer are overlayed
Together, then by processing so as to which adhesion is combined with each other, and makes composite non woven layer of cloth；
(2) on the calcium alginate nonwoven layer surface of above-mentioned composite non woven layer of cloth spray metal ion or nanometer silver paste liquid
Body.
7. the preparation method of claim 6, wherein step (1) is to mix hydrophobic fibre and hydrophilic fibre to pass through
Net is carded to, then by nonwoven layer made by needle point method.
8. the preparation method of claim 6 or 7, wherein spraying is to allow liquid is fine to turn to sub-micron grade even nanoscale, then
It is coated directly on calcium alginate nonwoven layer surface.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310342513.6A CN104338174B (en) | 2013-08-07 | 2013-08-07 | Bleeding-stopping patch with composite structure and preparation method thereof |
| PCT/CN2014/083847 WO2015018349A1 (en) | 2013-08-07 | 2014-08-07 | Hemostatic plaster having a composite structure and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310342513.6A CN104338174B (en) | 2013-08-07 | 2013-08-07 | Bleeding-stopping patch with composite structure and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104338174A CN104338174A (en) | 2015-02-11 |
| CN104338174B true CN104338174B (en) | 2017-05-03 |
Family
ID=52460675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310342513.6A Active CN104338174B (en) | 2013-08-07 | 2013-08-07 | Bleeding-stopping patch with composite structure and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN104338174B (en) |
| WO (1) | WO2015018349A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105536030B (en) * | 2016-01-08 | 2018-09-18 | 山东明德生物医学工程有限公司 | A kind of hemostasis promotees to repair dressing chip and preparation method thereof |
| CN105727346B (en) * | 2016-02-04 | 2019-08-27 | 中国科学院化学研究所 | A kind of hemostatic fabric and its preparation method and application |
| CN114763631A (en) * | 2021-01-11 | 2022-07-19 | 哈尔滨汇隽医药科技有限公司 | Non-woven material for medical dressing |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1935268A (en) * | 2006-10-18 | 2007-03-28 | 上海川本卫生材料有限公司 | Nano silver calcium alginate antibacterial dressing |
| WO2008127287A2 (en) * | 2006-10-11 | 2008-10-23 | Biolife, L.L.C. | Materials and methods for wound treatment |
| CN102492925A (en) * | 2011-12-13 | 2012-06-13 | 中国人民解放军总后勤部军需装备研究所 | Medical anti-microbial silver-plated dressing and preparation method thereof |
| CN102908653A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Preparation method of antiseptic dressing for deep infection wound |
-
2013
- 2013-08-07 CN CN201310342513.6A patent/CN104338174B/en active Active
-
2014
- 2014-08-07 WO PCT/CN2014/083847 patent/WO2015018349A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008127287A2 (en) * | 2006-10-11 | 2008-10-23 | Biolife, L.L.C. | Materials and methods for wound treatment |
| CN1935268A (en) * | 2006-10-18 | 2007-03-28 | 上海川本卫生材料有限公司 | Nano silver calcium alginate antibacterial dressing |
| CN102492925A (en) * | 2011-12-13 | 2012-06-13 | 中国人民解放军总后勤部军需装备研究所 | Medical anti-microbial silver-plated dressing and preparation method thereof |
| CN102908653A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Preparation method of antiseptic dressing for deep infection wound |
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| CN104338174A (en) | 2015-02-11 |
| WO2015018349A1 (en) | 2015-02-12 |
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