CA2658183A1 - Inhibition mediee par une interference de l'arn de l'expression du gene de la proproteine convertase subtilisine kexine de type 9 (pcsk9) au moyen de petits acides nucleiques interferants(ansi) - Google Patents

Inhibition mediee par une interference de l'arn de l'expression du gene de la proproteine convertase subtilisine kexine de type 9 (pcsk9) au moyen de petits acides nucleiques interferants(ansi) Download PDF

Info

Publication number: CA2658183A1
Authority: CA; Canada
Prior art keywords: nucleotides; nucleic acid; sina; strand; double stranded
Prior art date: 2006-07-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002658183A

Other languages

English (en)

Inventor

James Mcswiggen

Vasant Jadhav

Chandra Vargeese

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sirna Therapeutics Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-17

Filing date

2007-07-17

Publication date

2008-01-24

2006-07-17 Priority claimed from US11/487,788 external-priority patent/US20070173473A1/en

2007-07-17 Application filed by Individual filed Critical Individual

2008-01-24 Publication of CA2658183A1 publication Critical patent/CA2658183A1/fr

Status Abandoned legal-status Critical Current

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235000019156 vitamin B Nutrition 0.000 description 1
239000011720 vitamin B Substances 0.000 description 1
235000019168 vitamin K Nutrition 0.000 description 1
239000011712 vitamin K Substances 0.000 description 1
150000003721 vitamin K derivatives Chemical class 0.000 description 1
229940045999 vitamin b 12 Drugs 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
229940046010 vitamin k Drugs 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
SFVVQRJOGUKCEG-OPQSFPLASA-N β-MSH Chemical compound C1C[C@@H](O)[C@H]2C(COC(=O)[C@@](O)([C@@H](C)O)C(C)C)=CCN21 SFVVQRJOGUKCEG-OPQSFPLASA-N 0.000 description 1

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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
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CA002658183A 2006-07-17 2007-07-17 Inhibition mediee par une interference de l'arn de l'expression du gene de la proproteine convertase subtilisine kexine de type 9 (pcsk9) au moyen de petits acides nucleiques interferants(ansi) Abandoned CA2658183A1 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US11/487,788 US20070173473A1 (en)	2001-05-18	2006-07-17	RNA interference mediated inhibition of proprotein convertase subtilisin Kexin 9 (PCSK9) gene expression using short interfering nucleic acid (siNA)
US11/487,788		2006-07-17
US86136906P	2006-11-28	2006-11-28
US60/861,369		2006-11-28
PCT/US2007/073723 WO2008011431A2 (fr)	2006-07-17	2007-07-17	INHIBITION MÉDIÉE PAR UNE INTERFÉRENCE DE L'ARN DE L'EXPRESSION DU GÈNE DE LA PROPROTÉINE CONVERTASE SUBTILISINE KEXINE DE TYPE 9 (PCSK9) AU MOYEN DE PETITS ACIDES NUCLÉIQUES INTERFÉRANTS(ANsi)

Publications (1)

Publication Number	Publication Date
CA2658183A1 true CA2658183A1 (fr)	2008-01-24

Family

ID=38957565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002658183A Abandoned CA2658183A1 (fr)	2006-07-17	2007-07-17	Inhibition mediee par une interference de l'arn de l'expression du gene de la proproteine convertase subtilisine kexine de type 9 (pcsk9) au moyen de petits acides nucleiques interferants(ansi)

Country Status (6)

Country	Link
EP (1)	EP2052079A2 (fr)
JP (1)	JP2010503382A (fr)
CN (1)	CN102124107A (fr)
AU (1)	AU2007275365A1 (fr)
CA (1)	CA2658183A1 (fr)
WO (1)	WO2008011431A2 (fr)

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2007
- 2007-07-17 AU AU2007275365A patent/AU2007275365A1/en not_active Abandoned
- 2007-07-17 CA CA002658183A patent/CA2658183A1/fr not_active Abandoned
- 2007-07-17 EP EP07813032A patent/EP2052079A2/fr not_active Withdrawn
- 2007-07-17 WO PCT/US2007/073723 patent/WO2008011431A2/fr active Application Filing
- 2007-07-17 JP JP2009520964A patent/JP2010503382A/ja not_active Withdrawn
- 2007-07-17 CN CN2007800269961A patent/CN102124107A/zh active Pending

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CN115368916A (zh) *	2016-04-05	2022-11-22	斯特拉斯堡大学	用于捕获分子靶标的液滴内表面工程

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Publication number	Publication date
JP2010503382A (ja)	2010-02-04
AU2007275365A1 (en)	2008-01-24
CN102124107A (zh)	2011-07-13
WO2008011431A8 (fr)	2009-11-05
WO2008011431A3 (fr)	2008-07-17
EP2052079A2 (fr)	2009-04-29
WO2008011431A2 (fr)	2008-01-24

Legal Events

Date	Code	Title	Description
2013-09-11	FZDE	Dead	Effective date: 20130717

Publication	Publication Date	Title
CA2658183A1 (fr)	2008-01-24	Inhibition mediee par une interference de l'arn de l'expression du gene de la proproteine convertase subtilisine kexine de type 9 (pcsk9) au moyen de petits acides nucleiques interferants(ansi)
US20070173473A1 (en)	2007-07-26	RNA interference mediated inhibition of proprotein convertase subtilisin Kexin 9 (PCSK9) gene expression using short interfering nucleic acid (siNA)
US8017761B2 (en)	2011-09-13	RNA interference mediated inhibition of Stearoyl-CoA desaturase (SCD) gene expression using short interfering nucelic acid (siNA)
US20090156533A1 (en)	2009-06-18	RNA INTERFERENCE MEDIATED INHIBITION OF STROMAL CELL-DERIVED FACTOR-1 (SDF-1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20090239931A1 (en)	2009-09-24	RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN TYROSINE PHOSPHATASE-1B (PTP-1B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20110313024A1 (en)	2011-12-22	RNA INTERFERENCE MEDIATED INHIBITION OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9 (PCSK9) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US7897753B2 (en)	2011-03-01	RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA)
US7662952B2 (en)	2010-02-16	RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA)
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CA2658183A1 - Inhibition mediee par une interference de l'arn de l'expression du gene de la proproteine convertase subtilisine kexine de type 9 (pcsk9) au moyen de petits acides nucleiques interferants(ansi) - Google Patents

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